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Younghoon Kim, Xianyu Wen, Jeong Mo Bae, Jung Ho Kim, Nam-Yun Cho, Gyeong Hoon Kang
The role of tumor-associated macrophages (TAMs) in colorectal cancer (CRC) remains elusive. In this study, we aimed to examine the correlation between TAMs, clinicopathological features, tumor-infiltrating lymphocytes (TILs), and prognosis in CRC via image analysis. Immunohistochemical staining for CD68 and CD163 was performed with pan-macrophage and M2-macrophage markers, respectively. Each marker was separately analyzed for intraepithelial and stromal area densities. All four macrophage densities showed a significant correlation with one another (p = 0...
June 15, 2018: Histopathology
Qi Chen, Ran An, Ju Zhou, Bin Yang
BACKGROUND: Perineural dexamethasone has been shown to prolong the duration of local anesthetic (LA) effect in regional anesthesia; however, the use of perineural dexamethasone as an adjuvant to to the transversus abdominis plane (TAP) block remains controversial. This meta-analysis sought to assess the efficacy of dexamethasone in prolonging the TAP block and enhancing recovery after abdominal surgery. METHODS: We identified and analyzed 9 RCTs published on or before September 30, 2017, regardless of the original language, after searching the following 6 bibliographic databases: PubMed, EMBASE, Medline, Springer, Ovid, and the Cochrane Library...
2018: PloS One
Chao-Hsien Lee, Shu-Chen Cheng, Hong-Yi Tung, Shih-Chang Chang, Ching-Yun Ching, Shu-Fen Wu
Background: Colorectal cancer is one of the most common malignancies in developed countries. The incidence of colorectal cancer (CRC) in Taiwan is rising. We aimed to determine the five-yr survival rate of patients diagnosed with CRC and determine factors affecting survival. Methods: All patients were identified from the Taiwan Cancer Data Base of the Medical Center Hospital in North Taiwan from 2007 to 2013. Data were collected using medical records and the cancer database...
April 2018: Iranian Journal of Public Health
Chumei Huang, Yaqing Li, Yubo Guo, Zuoquan Zhang, Guoda Lian, Yinting Chen, Jian Li, Yonghui Su, Jiajia Li, Kege Yang, Shaojie Chen, Hong Su, Kaihong Huang, Linjuan Zeng
The molecular mechanism of perineural invasion (PNI) is unclear, and insufficient detection during early-stage PNI in vivo hampers its investigation. We aimed to identify a cytokine paracrine loop between pancreatic ductal adenocarcinoma (PDAC) cells and nerves and established a noninvasive method to monitor PNI in vivo . Methods: A Matrigel/ dorsal root ganglia (DRG) system was used to observe PNI in vitro , and a murine sciatic nerve invasion model was established to examine PNI in vivo . PNI was assessed by MRI with iron oxide nanoparticle labeling ...
2018: Theranostics
Hao Gao, Yong Gao, Lingdi Yin, Guangfu Wang, Jishu Wei, Kuirong Jiang, Yi Miao
Background: Pancreatic solid pseudopapillary tumors (SPTs) are rare neoplasms with low-grade malignancy. The main treatment for them is surgical resection. However, some SPTs relapse after resection. The risk factors associated with the recurrences of resected SPTs remain controversial to date. We performed a systematic review and meta-analysis to identify the risk factors of the recurrences of pancreatic SPTs. Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library from their inception to December 2017...
2018: Journal of Cancer
Christopher Weiyang Liu, David Flamer
The perineural administration of alcohol or phenol results in protein denaturation and, consequently, neurolysis. This can produce long-lasting analgesia, with a duration of 3-6 months. Although neurolytic blocks for the brachial plexus have been described in multiple review articles and textbooks, they are rarely performed. As such, little is known about the efficacy and adverse effect profile of this commonly described treatment. In this article, we report the outcomes of a patient who underwent a left brachial plexus neurolytic block for the management of upper limb pain arising from a malignant peripheral nerve sheath tumor...
June 11, 2018: A&A practice
Mustafa Karaca, Deniz Tural, Hakan Kocoglu, Fatih Selcukbiricik, Irem Bilgetekin, Ahmet Özet
Objective: The age-adjusted mortality rate due to gastric cancer was reported to increase with age. This study aims to investigate the results of adjuvant chemotherapy in patients aged 65 years or older comparing with younger patients and focusing on its impact on survival. Materials and Methods: A total of 406 patients with nonmetastatic gastric cancer that consisted of 283 patients younger than 65 years (range: 23-64 years) and 123 patients 65 years of age or older (range: 65-75 years) were retrospectively evaluated...
April 2018: Journal of Cancer Research and Therapeutics
Richard L Kahn, Jennifer Cheng, Yuliya Gadulov, Kara G Fields, Jacques T YaDeau, Lawrence V Gulotta
BACKGROUND AND OBJECTIVES: Perineural dexamethasone and intravenous (IV) dexamethasone have been shown to prolong peripheral nerve block duration. The effects of perineural and IV dexamethasone have only been compared at doses of 4 mg or greater. This triple-blind, randomized trial examined the effect of 1 mg IV versus perineural dexamethasone on interscalene block (ISB) analgesia duration. METHODS: Patients undergoing ambulatory shoulder arthroscopy received an ultrasound-guided ISB with 15 mL bupivacaine 0...
June 8, 2018: Regional Anesthesia and Pain Medicine
Liam C Macleod, Robert M Turner, Samia Lopa, Lee A Hugar, Benjamin J Davies, Bruce Ben-David, Jacques E Chelly, Bruce L Jacobs, Joel B Nelson
BACKGROUND: Recent studies suggest that anesthetic technique during radical prostatectomy for prostate cancer may affect recurrence or progression. This association has previously been investigated in series that employ epidural analgesia. The objective of this study is to determine the association between the use of a multimodal analgesic approach incorporating paravertebral blocks and risk of biochemical recurrence following open radical prostatectomy. PATIENTS AND METHODS: Using a prospective database of 3,029 men undergoing open radical prostatectomy by a single surgeon, we identified 2,909 men who received no neoadjuvant androgen deprivation and had at least 1 year of follow up...
June 7, 2018: Urologic Oncology
Safiye Tokgoz Ozal, Ercan Inci, Aysegul Akdogan Gemici, Hurriyet Turgut, Murat Cikot, Mehmet Karabulut
PURPOSE: To investigate the relationship between diffusion tensor imaging (DTI) parameters such as fractional anisotropy (FA), mean diffusivity (MD), relative anisotropy (RA), and volume ratio (VR) values, and prognostic factors of invasive breast cancer. MATERIALS AND METHODS: This retrospective study examined 63 patients with pathologically confirmed invasive breast cancers. The patients underwent pre-operative diffusion-weighted magnetic resonance imaging (MRI) at 3...
April 5, 2018: Clinical Imaging
Xiaofeng Yao, Yu Wang, Yuansheng Duan, Qiang Zhang, Ping Li, Rui Jin, Yingjie Tao, Wenchao Zhang, Xudong Wang, Chao Jing, Xuan Zhou
Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IGFBP2 overexpression could dramatically improve motility and invasion capacity of SACC cells in vitro. Mechanically, IGFBP2 enhanced expression of ZEB1 in a NF-κB (p65)-dependent manner and then promoted epithelial-mesenchymal transition (EMT) in SACC...
June 6, 2018: Cancer Letters
Aung Win Tin, Eleanor Smith, Rebecca Hepworth, Julie Walker, David Wilson, Nick Wadd
INTRODUCTION: Perioperative epirubicin, cisplatin and 5-FU or capecitabine (ECF/X) chemotherapy is recognised as a standard of care for patients with resectable gastroesophageal adenocarcinoma; however, there is limited evidence regarding its use in older patients. The aims of this study were to assess the effectiveness and tolerability of perioperative ECX chemotherapy in patients aged ≥70 years-old (group 1) compared with a younger population (group 2), and to assess differences in the histology of these groups...
June 5, 2018: Journal of Geriatric Oncology
Saurabh Bobdey, Manish Mair, Sudhir Nair, Deepa Nair, Ganesh Balasubramaniam, Pankaj Chaturvedi
BACKGROUND AND OBJECTIVES: T4 squamous cell carcinomas of the buccal mucosa is known to have ominous outcome. The aim of this study was to develop a nomogram for T4 buccal mucosa cancer patients and demonstrate the difference in survival based on prognosticators beyond those covered by the traditional TNM staging system. METHODS: We examined medical records of treatment naïve 205 T4 buccal mucosa cancer patients operated between January 1, 2009, and December 31, 2014...
June 2018: Oral Oncology
Si-Ru Chen, Yu-Ping Shen, Tsung-Yen Ho, Liang-Cheng Chen, Yung-Tsan Wu
RATIONALE: Perineural injection with dextrose could be a novel intervention for peripheral entrapment neuropathy. However, this intervention has not been reported for treating radial nerve palsy (RNP). Here, we present a case with RNP having outstanding improvement after 2 sessions of ultrasound-guided perineural injection with 5% dextrose (D5W). PATIENT CONCERNS: A 62-year-old woman presented with difficulty and weakness in extension of her left wrist and fingers after she slept with the arm compressed against her body...
June 2018: Medicine (Baltimore)
Andrew G Kuang, J Curtis Nickel, Gerald L Andriole, Ramiro Castro-Santamaria, Stephen J Freedland, Daniel M Moreira
OBJECTIVES: To evaluate the association between acute and chronic inflammation with the presence of perineural invasion (PNI) in prostate biopsies positive for prostate cancer (PCa). MATERIAL AND METHODS: Retrospective analysis of 1399 prostate biopsies positive for PCa in the Reduction by Dutasteride of PCa Events (REDUCE) study. PCa, acute and chronic prostate inflammation, and PNI were assessed by central pathology review. The association between acute and chronic inflammations with PNI was evaluated using chi-square test and Kruskal-Wallis tests, and logistic regression adjusting for clinicopathological and biochemical variables...
June 6, 2018: BJU International
Nwokoro Chingbundu Collins, Emmanuel Ezekiel Ayodeji, Fatungase Oluwabunmi Motunrayo, Salami Babatunde Abayomi, Ogundele Ibukunolu Olufemi, Amosu Lukmon Olusesan
Background: Neurofibromatosis is a genetically inherited disorder of the nervous system (brain and spinal cord) which mainly affects the development of nerve (neural) cell tissues, causing tumors (neurofibromas) to develop on nerves. It is the most common single gene disorder of the nervous system and inheritance is through autosomal dominance. They are usually classified into types 1 and 2, the type 1 is the commoner type and also known as superficial neurofibroma. Plexiform neurofibromas are the next most common type of tumor in individuals with type 1 neurofibroma...
March 2018: Malawi Medical Journal: the Journal of Medical Association of Malawi
A Saporito, C Quadri, X Capdevila
Injection pressure monitoring provides valuable information to prevent intraneural injections and possibly consequent nerve damage during peripheral nerve block. However, the measurement of injection pressure along the injection line is inaccurate as it is influenced by several variables. The aim of this study was to test a new system for precise injection pressure monitoring at the needle tip in a cadaveric model. The system consists of a miniaturised pressure sensor embedded within the needle shaft that is connected via an optical fibre to an external control unit...
June 2, 2018: Anaesthesia
Rosa Jahangiri, Fatemeh Mosaffa, Masoumeh Gharib, Amir Nader Emami Razavi, Afshin Abdirad, Khadijeh Jamialahmadi
PAX2 (paired box gene 2) is a transcription factor, which is involved in both cell proliferation and carcinogenesis. This study aimed to investigate PAX2 expression in tamoxifen resistant (TAM-R) and tamoxifen sensitive (TAM-S) breast carcinoma patients and analyze its correlation with clinicopathological characteristics and survival. Immunohistochemical analysis was performed to evaluate PAX2 protein expression in 36 TAM-R and 36 TAM-S formalin-fixed paraffin-embedded (FFPE) breast tumor tissues. Data analysis indicated that PAX2 expression was significantly higher in TAM-S group in comparison to TAM-R (P = 0...
June 2018: Tissue & Cell
Yasuhiro Ito, Yuta Abe, Tomohisa Egawa, Minoru Kitago, Osamu Itano, Yuko Kitagawa
Aim: To determine the factors associated with early recurrence in patients with distal cholangiocarcinoma after pancreaticoduodenectomy (PD). Patients and Methods: Sixty-one patients with distal cholangiocarcinoma were enrolled. The clinical data and histopathological findings were collected retrospectively. Results: Patients were divided into two groups as follows: 16 patients (26%) with early recurrence and 45 patients (74%) with late recurrence or no recurrence...
2018: Gastroenterology Research and Practice
Jung Wook Huh, Seong Hyeon Yun, Seok Hyung Kim, Yoon Ah Park, Yong Beom Cho, Hee Cheol Kim, Woo Yong Lee, Hee Chul Park, Doo Ho Choi, Joon Oh Park, Young Suk Park, Ho-Kyung Chun
BACKGROUND: The prognostic role of post-chemoradiotherapy (CRT) carcinoembryonic antigen (CEA) level is not clear. We evaluated the prognostic significance of post-CRT CEA level in patients with rectal cancer after preoperative CRT. METHODS: We reviewed 659 consecutive patients who underwent preoperative CRT and total mesorectal excision for non-metastatic rectal cancer. Patients were categorized into two groups according to post-CRT serum CEA level: low CEA (< 5 ng/mL) and high CEA (≥ 5 ng/mL)...
May 29, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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