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https://www.readbyqxmd.com/read/29232423/a-case-of-leprosy-in-central-florida
#1
Kathryn L Anderson, John P Minni, Michael A Nowak, Laszlo J Karai, Eugene Sanik
Hansen disease, also known as leprosy, is a chronic granulomatous infectious disease that is caused by Mycobacterium leprae. We report an unusual case of a 65-year-old man who presented with multiple anesthetic, annular, erythematous, scaly plaques with a raised border without any known exposures to leprosy. Histologic examination revealed a perineural lymphohistiocytic infiltrate and rare bacilli demonstrated on Fite staining. After confirmation with polymerase chain reaction (PCR) and consultation with the National Hansen's Disease Program (Baton Rouge, Louisiana), the patient was placed on a regimen of rifampicin 600 mg once monthly and dapsone 100 mg once daily for 6 months, which showed considerable improvement...
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29226148/transition-from-deep-regional-blocks-toward-deep-nerve-hydrodissection-in-the-upper-body-and-torso-method-description-and-results-from-a-retrospective-chart-review-of-the-analgesic-effect-of-5-dextrose-water-as-the-primary-hydrodissection-injectate-to-enhance
#2
Stanley K H Lam, Kenneth Dean Reeves, An-Lin Cheng
Deep nerve hydrodissection uses fluid injection under pressure to purposely separate nerves from areas of suspected fascial compression, which are increasingly viewed as potential perpetuating factors in recalcitrant neuropathic pain/complex regional pain. The usage of 5% dextrose water (D5W) as a primary injectate for hydrodissection, with or without low dose anesthetic, could limit anesthetic-related toxicity. An analgesic effect of 5% dextrose water (D5W) upon perineural injection in patients with chronic neuropathic pain has recently been described...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29223019/are-pathological-high-risk-features-in-locally-advanced-rectal-cancer-a-useful-selection-tool-for-adjuvant-chemotherapy
#3
Marloes Swets, Peter J K Kuppen, Erik J Blok, Hans Gelderblom, Cornelis J H van de Velde, Iris D Nagtegaal
BACKGROUND: Several histological high-risk factors are used as an indication for adjuvant therapy in stage II colon cancer. Those and other factors, including lymphatic invasion, perineural invasion (PNI), venous invasion and tumour budding are associated with decreased outcome. In this study, we evaluated the prognostic and predictive values of these biomarkers in a cohort of rectal cancer patients. MATERIALS AND METHODS: The trial-based cohort consisted of 221npTNM stage II-III rectal cancer patients, included in the PROCTOR/SCRIPT trial, a multicentre randomised phase III trial...
December 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29216709/effect-of-adjuvant-chemotherapy-on-stage-ii-colon-cancer-analysis-of-korean-national-data
#4
Min Ki Kim, Daeyoun David Won, Sun Min Park, Taejung Kim, Sung Ryong Kim, Seong Taek Oh, Seung Kook Sohn, Mi Yeon Kang, In Kyu Lee
Purpose: Debates exist regarding the effectiveness of adjuvant chemotherapy for stage II colon cancer. This study aimed to investigate the current status of adjuvant chemotherapy and its impact on survival for Korean stage II colon cancer patients by analyzing the National Quality Assessment data. Methods: A total of 7880 patients who underwent curative resection for stage II colon adenocarcinoma between January 2011 and December 2014 in Korea were selected randomly as evaluation subjects for the quality assessment...
December 7, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29207615/pik3ca-mutations-are-associated-with-increased-tumor-aggressiveness-and-akt-activation-in-gastric-cancer
#5
Ji-Won Kim, Hye Seung Lee, Kyung Han Nam, Soyeon Ahn, Jin Won Kim, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Keun-Wook Lee
PIK3CA mutations are frequent in gastric cancer. However, their pathological and clinical implications are still unclear. We analyzed the clinicopathological characteristics according to the PIK3CA mutation status of patients with stage IB-IV disease who underwent gastrectomy between May 2003 and Dec. 2005 (cohort 1; n = 302) and of those with stage IV disease who received gastrectomy between Jul. 2006 and Dec. 2012 (cohort 2; n = 120). PIK3CA mutations were detected in 40 patients (13.2%) in cohort 1. In these patients, PIK3CA-mutant tumors were more frequently located in the upper third of the stomach (p = 0...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203074/microscopic-biliary-and-perineural-invasion-and-clinical-outcome-after-neoadjuvant-bevacizumab-based-chemotherapy-and-liver-resection-in-patients-with-colorectal-liver-metastases
#6
Judith Stift, Alexandra Graf, Christoph Schwarz, Dietmar Tamandl, Patrick Starlinger, Merima Herac, Andrea Beer, Friedrich Wrba, Martin Bodingbauer, Klaus Kaczirek, Stefan Stremitzer
BACKGROUND: The value of microscopic biliary and perineural invasion as prognostic biomarkers in patients with resectable colorectal liver metastases (CLM) who undergo neoadjuvant chemotherapy and liver resection is still unclear. This retrospective study was performed to elucidate this issue. METHODS: Histologic slides of resected CLM of patients who underwent neoadjuvant bevacizumab-based chemotherapy and liver resection were investigated with respect to biliary and perineural invasion...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29199015/contemporary-prognostic-indicators-for-prostate-cancer-incorporating-international-society-of-urological-pathology-recommendations
#7
REVIEW
Lars Egevad, Brett Delahunt, Glen Kristiansen, Hemamali Samaratunga, Murali Varma
Prognostic assessment is a key element in the management of patients with prostate cancer as it informs both treatment, follow-up and outcome prediction. Tumour grade should be based upon the novel and evidence-based recommendations of the International Society of Urological Pathology (ISUP) Consensus Conference of 2014, with ISUP grades 1-5 being derived from 2005 ISUP modified Gleason grading, i.e., ISUP grade 1 (3 + 3 = 6), grade 2 (3 + 4 = 7), grade 3 (4 + 3 = 7), grade 4 (3 + 5 = 8, 5 + 3 = 8, 4 + 4 = 8), and grade 5 (4 + 5 = 9 5 + 4 = 9, 5 + 5 = 10)...
November 30, 2017: Pathology
https://www.readbyqxmd.com/read/29196315/phosphorylated-ccaat-enhancer-binding-protein-%C3%AE-contributes-to-rat-hiv-related-neuropathic-pain-in-vitro-and-in-vivo-studies
#8
Hyun Yi, Shue Liu, Yuta Kashiwagi, Daigo Ikegami, Wan Huang, Hirotsugu Kanda, Takafumi Iida, Ching-Hang Liu, Keiya Takahashi, David A Lubarsky, Shuanglin Hao
Chronic pain is increasingly recognized as an important comorbidity of HIV-infected patients, however, the exact molecular mechanisms of HIV-related pain are still elusive. CCAAT/enhancer binding proteins (C/EBPs) are expressed in various tissues, including the central nervous system. C/EBPβ, one of C/EBPs is involved in the progression of HIV/AIDS, but the exact role of C/EBPβ and its upstream factors are not clear in HIV pain state. Here, we used a neuropathic pain model of perineural HIV envelope glycoprotein gp120 application onto the rat sciatic nerve to test the role of phosphorylated C/EBPβ (pC/EBPβ) and its upstream pathway in the spinal cord dorsal horn (SCDH)...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29194286/desmoplastic-melanoma-of-the-periorbital-region
#9
Sudip Thakar, Thomas Kandl, Oded Sagiv, Devjyoti Tripathy, Michael T Tetzlaff, Sahil Kapur, Jeffrey Myers, Wen-Jen Hwu, Bita Esmaeli, Bashar M Y Jaber
Desmoplastic melanoma (DM) is a rare subtype of melanoma and an even smaller proportion of periocular melanomas. Here, the authors report 2 cases of DM in the periocular region. Staged according to the American Joint Committee on Cancer (AJCC) eighth edition classification, patient 1 presented with a stage IIIC (pT4apN1cM0) DM in the left lateral canthus with upper and lower eyelid and patient 2 presented with a stage IIIB (T4aN1bM0) DM in the left brow and supraorbital region with a parotid lymph node metastasis...
November 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29192190/schwann-cell-trpa1-mediates-neuroinflammation-that-sustains-macrophage-dependent-neuropathic-pain-in-mice
#10
Francesco De Logu, Romina Nassini, Serena Materazzi, Muryel Carvalho Gonçalves, Daniele Nosi, Duccio Rossi Degl'Innocenti, Ilaria M Marone, Juliano Ferreira, Simone Li Puma, Silvia Benemei, Gabriela Trevisan, Daniel Souza Monteiro de Araújo, Riccardo Patacchini, Nigel W Bunnett, Pierangelo Geppetti
It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells. We found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and oxidative stress, whereas TRPA1 silencing in Schwann cells reduced both allodynia and neuroinflammation. Activation of Schwann cell TRPA1 evoked NADPH oxidase 1 (NOX1)-dependent H2O2 release, and silencing or blocking Schwann cell NOX1 attenuated nerve injury-induced macrophage infiltration, oxidative stress and allodynia...
December 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29191689/does-the-surgical-waiting-list-affect-pathological-and-survival-outcome-in-resectable-pancreatic-ductal-adenocarcinoma
#11
Giovanni Marchegiani, Stefano Andrianello, Giampaolo Perri, Erica Secchettin, Laura Maggino, Giuseppe Malleo, Claudio Bassi, Roberto Salvia
BACKGROUND: High-volume centers have to deal with long surgical waiting-lists leading to a potential delay in treatment. This study assessed whether a longer time from diagnosis to surgery worsened pathological and survival outcomes in resectable pancreatic ductal adenocarcinoma (PDAC). METHODS: A retrospective analysis of patients treated for resectable PDAC. Difference in size between preoperative CT-scan and specimen, pathological features, the rate of vascular and R1 resections as well as recurrence and survival were analyzed depending on the waiting time using a 30-day cut-off...
November 27, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29189711/early-postoperative-low-expression-of-rad50-in-rectal-cancer-patients-associates-with-disease-free-survival
#12
Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Maxine Revoltar, Stephanie H Lim, Thein-Ga Tut, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin, Cheok Soon Lee
BACKGROUND: Molecular biomarkers have the potential to predict response to the treatment of rectal cancer. In this study, we aimed to evaluate the prognostic and clinicopathological implication of RAD50 (DNA repair protein RAD50 homolog) expression in rectal cancer. METHODS: A total of 266 rectal cancer patients who underwent surgery and received chemo- and radiotherapy between 2000 and 2011 were involved in the study. Postoperative RAD50 expression was determined by immunohistochemistry in surgical samples (n = 266)...
November 30, 2017: Cancers
https://www.readbyqxmd.com/read/29188641/-role-of-ccl5-ccr5-in-the-perineural-invasion-of-salivary-adenoid-cystic-carcinoma-cells
#13
Li Tianyi, Shen Zhiyuan
OBJECTIVE: This study aimed the role of the CCL5/CCR5 axis in the perineural invasion of salivary adenoid cystic carcinoma (SACC) cells. METHODS: Immunohistochemical analysis and flow cytometric analysis were conducted to detect the expression of the chemokine receptor CCR5 in SACC cells. Enzyme linked immunosorbent assay (ELISA) was performed to determine the expression of CCL5 in the supernate of human nerve cells. The flow cytometric analysis was applied to observe the changes in F-actin in SACC-LM cells, which were pretreated with CCL5...
October 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29188232/colorectal-cancer-cells-adhere-to-and-migrate-along-the-neurons-of-the-enteric-nervous-system
#14
Emilie Duchalais, Christophe Guilluy, Steven Nedellec, Melissa Touvron, Anne Bessard, Yann Touchefeu, Céline Bossard, Hélène Boudin, Guy Louarn, Michel Neunlist, Laurianne Van Landeghem
Background & Aims: In several types of cancers, tumor cells invade adjacent tissues by migrating along the resident nerves of the tumor microenvironment. This process, called perineural invasion, typically occurs along extrinsic nerves, with Schwann cells providing physical guidance for the tumor cells. However, in the colorectal cancer microenvironment, the most abundant nervous structures belong to the nonmyelinated intrinsic enteric nervous system (ENS). In this study, we investigated whether colon cancer cells interact with the ENS...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29181056/prognostic-implications-of-phosphatidylinositol-3-kinase-akt-signaling-pathway-activation-in-gastric-carcinomas
#15
Paula Blandina Ola Chiappini, Ivan Ucella Dantas de Medeiros, Luiz Guilherme Cenaglia Lima, Jose Humberto Fregnani, Suely Nonogaki, Wilson Luiz da Costa, Felipe Jose Fernandez Coimbra, Milton Jose de Barros E Silva, Celso Abdon Lopes de Mello, Clovis Antonio Lopes Pinto, Maria Dirlei Begnami
Introduction: Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays a critical role in carcinogenesis and resistance to anticancer drugs. In this study, gastric carcinomas (GC) were investigated and statistical analyses were performed concerning the correlation between the clinicopathological features and activation of the PI3K/AKT pathway. Material and methods: Immunohistochemistry for p-AKT, p-mTOR and PTEN was performed in 239 GC and 200 non-neoplastic gastric tissues...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29180895/postoperative-pain-management-in-the-postanesthesia-care-unit-an-update
#16
REVIEW
Jie Luo, Su Min
Acute postoperative pain remains a major problem, resulting in multiple undesirable outcomes if inadequately controlled. Most surgical patients spend their immediate postoperative period in the postanesthesia care unit (PACU), where pain management, being unsatisfactory and requiring improvements, affects further recovery. Recent studies on postoperative pain management in the PACU were reviewed for the advances in assessments and treatments. More objective assessments of pain being independent of patients' participation may be potentially appropriate in the PACU, including photoplethysmography-derived parameters, analgesia nociception index, skin conductance, and pupillometry, although further studies are needed to confirm their utilities...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29177141/a-case-of-circumscribed-scalp-morphea-with-perineural-lymphocytes-on-pathology
#17
David Saceda-Corralo, Aron G Nusbaum, Paolo Romanelli, Mariya Miteva
Scalp morphea presents as a scarring alopecia in en coup du sabre pattern. We report an unusual presentation of a round hairless patch of morphea on the occipital scalp present for 15 years. The scalp lesion aligned with 2 other hyperpigmented lesions of biopsy-proven morphea in the lower back. Pathology of horizontal sections from the scalp lesion showed follicular dropout, thickening of the collagen bundles, and preserved eccrine and follicular structures. Marked lymphocytic perineural infiltrate, a reported clue to the diagnosis of scalp morphea, contributed to the diagnosis...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29173667/ultrasound-guided-interventions-of-the-cervical-spine-and-nerves
#18
REVIEW
Ke-Vin Chang, Wei-Ting Wu, Levent Özçakar
High-resolution ultrasound (US) enables prompt depiction of muscles, tendons, ligaments, and peripheral nerves. It seems to be the best imaging modality for guiding perineural injections. The most complicated neurovascular network of the musculoskeletal system surrounds the cervical spine; so injection to that region is never an easy task. This article elaborates the regional anatomy and the use of US scanning and guidance for cervical interventions; for example, cervical root, superficial cervical plexus, stellate ganglion, cervical medial branch, greater occipital nerve, and third occipital nerve...
February 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29171437/mir-30c-promotes-schwann-cell-remyelination-following-peripheral-nerve-injury
#19
Sheng Yi, Qi-Hui Wang, Li-Li Zhao, Jing Qin, Ya-Xian Wang, Bin Yu, Song-Lin Zhou
Differential expression of miRNAs occurs in injured proximal nerve stumps and includes miRNAs that are firstly down-regulated and then gradually up-regulated following nerve injury. These miRNAs might be related to a Schwann cell phenotypic switch. miR-30c, as a member of this group, was further investigated in the current study. Sprague-Dawley rats underwent sciatic nerve transection and proximal nerve stumps were collected at 1, 4, 7, 14, 21, and 28 days post injury for analysis. Following sciatic nerve injury, miR-30c was down-regulated, reaching a minimum on day 4, and was then upregulated to normal levels...
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29167905/clinics-in-diagnostic-imaging-181-cervical-spine-perineural-cysts
#20
Wei Kiong Cheong, Bak Siew Steven Wong
A 47-year-old woman who underwent resection of known spinal meningioma at the T1 level returned for postoperative magnetic resonance imaging of the cervical spine. Incidentally, thin-walled structures with signal intensities that are similar to those of cerebrospinal fluid were found to be present in the left neural exit canal at the C7-T1 level and bilateral neural exit canals at the C6-7 level. Imaging findings were in keeping with perineural cysts. Cervical spine perineural cysts are likely underreported, as most of them are asymptomatic...
November 2017: Singapore Medical Journal
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