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https://www.readbyqxmd.com/read/29678584/genome-wide-profiles-of-metastasis-associated-mrnas-and-micrornas-in-salivary-adenoid-cystic-carcinoma
#1
Shubin Wang, Lei Zhang, Pengwei Shi, Yuanyuan Zhang, Hong Zhou, Xuanping Cao
Salivary adenoid cystic carcinoma (SACC) is often accompanied with poor prognosis due to local recurrence, distant metastasis, and perineural invasion. The mechanism involved in SACC metastasis is not yet fully understood. In this study, we profiled the expression of messenger RNA (mRNA) and microRNA (miRNA) in an SACC cell line, ACC-2, and a highly metastatic SACC cell line, ACC-M, using high-throughput sequencing. We discovered that: (1) differentially expressed (DE) mRNAs and DE miRNAs are potentially involved in SACC metastasis; (2) multiple regulatory interactions between DE miRNAs and DE mRNAs exist; and (3) miR-338-5p/3p target LAMC2 to impair motility and invasion of ACC-M and MDA-MB-231 cells...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29676798/afferent-neural-feedback-overrides-the-modulating-effects-of-arousal-hypercapnia-and-hypoxemia-on-neonatal-cardio-respiratory-control
#2
Kathleen J Lumb, Jennifer M Schneider, Thowfique Ibrahim, Anita Rigaux, Shabih U Hasan
KEY POINTS: Evidence at whole animal, organ-system, and cellular and molecular levels suggests that afferent volume feedback is critical for establishment of adequate ventilation at birth. Due to the irreversible nature of vagal ablation studies to date, it was difficult to quantify the roles of afferent volume input, arousal and changes in blood gas tensions on neonatal respiratory control. During reversible perineural vagal block, profound apneas, and hypoxemia and hypercarbia were observed necessitating termination of perineural blockade...
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29675762/high-risk-stage-ii-colon-cancer-not-all-risks-are-created-equal
#3
Blake D Babcock, Mayada A Aljehani, Brice Jabo, Audrey H Choi, John W Morgan, Matthew J Selleck, Fabrizio Luca, Elizabeth Raskin, Mark E Reeves, Carlos A Garberoglio, Sharon S Lum, Maheswari Senthil
INTRODUCTION: Adjuvant chemotherapy is recommended in patients with stage II colon cancer with high-risk features (HRF). However, there is no quantification of the amount of risk conferred by each HRF or the overall survival (OS) benefit gained by chemotherapy based on the risk factor. OBJECTIVE: To assess survival benefits associated with adjuvant chemotherapy among stage II colon cancer patients having one or more HRF [T4 tumors, less than 12 lymph nodes examined (< 12LN), positive margins, high-grade tumor, perineural invasion (PNI), and lymphovascular invasion (LVI)]...
April 19, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29672550/tumor-budding-is-an-independent-prognostic-marker-in-early-stage-oral-squamous-cell-carcinoma-with-special-reference-to-the-mode-of-invasion-and-worst-pattern-of-invasion
#4
Shota Shimizu, Akihiro Miyazaki, Tomoko Sonoda, Kazushige Koike, Kazuhiro Ogi, Jun-Ichi Kobayashi, Takeshi Kaneko, Tomohiro Igarashi, Megumi Ueda, Hironari Dehari, Akira Miyakawa, Tadashi Hasegawa, Hiroyoshi Hiratsuka
Pathologically proven regional lymph node metastasis affects the prognosis in early stage oral cancer. Therefore we investigated invasive tumor patterns predicting nodal involvement and survival in patients with clinically node-negative T1 and T2 oral squamous cell carcinoma (cT1,2N0M0 OSCC). Ninety-one cases of cT1,2N0M0 OSCC treated with transoral resection of the primary tumor were assessed based on 3 types of invasive tumor patterns on histopathologic and pancytokeratin-stained immunohistological sections: the mode of invasion, worst pattern of invasion (WPOI), and tumor budding...
2018: PloS One
https://www.readbyqxmd.com/read/29671218/neuroimaging-of-meckel-s-cave-in-normal-and-disease-conditions
#5
REVIEW
Ajay Malhotra, Long Tu, Vivek B Kalra, Xiao Wu, Ali Mian, Rajiv Mangla, Elias Michaelides, Pina Sanelli, Dheeraj Gandhi
Meckel's cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel's cave; (2) to describe imaging findings that identify disease involving Meckel's cave; (3) to present case examples of trigeminal and non-trigeminal processes affecting Meckel's cave...
April 18, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29668608/optimal-dose-of-perineural-dexmedetomidine-for-interscalene-brachial-plexus-block-to-control-postoperative-pain-in-patients-undergoing-arthroscopic-shoulder-surgery-a-prospective-double-blind-randomized-controlled-study
#6
Hong Soo Jung, Kwon Hui Seo, Jae Hyuk Kang, Jin-Young Jeong, Yong-Shin Kim, Na-Re Han
BACKGROUND: Adjuvant perineural dexmedetomidine can be used to prolong the analgesic effect of interscalene brachial plexus block (ISB). We investigated the optimal dose of dexmedetomidine in ISB for postoperative analgesia in patients undergoing arthroscopic shoulder surgery. METHODS: One hundred patients scheduled for elective shoulder arthroscopic surgery were enrolled in this randomized, double-blind study. Ultrasound-guided ISB was performed before general anesthesia using 22 mL of ropivacaine 0...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29666945/carbonic-anhydrase-9-expression-in-well-differentiated-pancreatic-neuroendocrine-neoplasms-might-be-associated-with-aggressive-behavior-and-poor-survival
#7
Joo Young Kim, Sang Hwa Lee, Soyeon An, Sung Joo Kim, You-Na Sung, Ki-Byung Song, Dae Wook Hwang, Song Cheol Kim, Seung-Mo Hong
Well-differentiated pancreatic neuroendocrine neoplasms/tumors (PanNETs) are rare neoplasms with diverse clinical behavior. Biomarker discovery is important for predicting clinical course and prognosis of PanNET patients. Carbonic anhydrase 9 (CA9) and vimentin are hypoxia and epithelial-mesenchymal transition-related proteins of which expression in many carcinomas has been associated with poor prognosis, but their significance in PanNET has yet to be determined. We assessed CA9 and vimentin expression in 164 PanNETs and compared this with clinicopathologic characteristics...
April 18, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29666812/tumor-progression-the-neuronal-input
#8
REVIEW
Marco Arese, Federico Bussolino, Margherita Pergolizzi, Laura Bizzozero, Davide Pascal
One of the challenges of cancer is its heterogeneity and rapid capacity to adapt. Notwithstanding significant progress in the last decades in genomics and precision medicine, new molecular targets and therapies appear highly necessary. One way to approach this complex problem is to consider cancer in the context of its cellular and molecular microenvironment, which includes nerves. The peripheral nerves, the topic of this review, modulate the biological behavior of the cancer cells and influence tumor progression, including the events related to the metastatic spread of the disease...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664183/posterior-tibial-perforators-relationship-with-superficial-nerves-and-veins-a-cadaver-study
#9
Antonio Bulla, Alberto Bolletta, Luca Fiorot, Matteo Maffei, Pasquale Bandiera, Vincent Casoli, Andrea Montella, Gian Vittorio Campus
BACKGROUND: Most authors have evaluated the location of lower leg arterial perforators, but little is still known about the relationship between the arterial network and great saphenous vein (GSV) and saphenous nerve (SN). The aim of this study is to evaluate the relationship between the arterial network of the posterior tibial artery perforators, the cutaneous nerves, and the superficial venous system in the lower one third of the leg. METHODS: Eighteen lower limbs from cadavers were used for this study...
April 17, 2018: Microsurgery
https://www.readbyqxmd.com/read/29663304/predictive-nomograms-for-synchronous-distant-metastasis-in-rectal-cancer
#10
Apostolos Gaitanidis, Michail Alevizakos, Alexandra Tsaroucha, Christos Tsalikidis, Michail Pitiakoudis
BACKGROUND: Nomograms may be used to quantitatively assess the probability of synchronous distant metastasis. The purpose of this study is to develop predictive nomograms for the presence of synchronous distant metastasis in patients with rectal cancer. METHODS: A retrospective analysis of the Surveillance Epidemiology and End Results database was performed for cases diagnosed between 2010 and 2014. RESULTS: Overall, 46,785 patients with rectal cancer (27,773 [59...
April 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29662968/adnexal-masses-or-perineural-tarlov-cysts-differentiation-by-imaging-techniques-a-case-report
#11
Firoozeh Ahmadi, Farnaz Akhbari
Background: Perineural cysts formed within the nerve-root sheath at the dorsal root ganglion. They are most commonly located in the arachnoid covering the junction of the dorsal ganglion and nerve root. They are usually asymptomatic, incidental findings, usually located in the lumbar and sacral region of the spinal canal. It is important to consolidate the imaging findings of this rare disease so clinicians can become more clinically relevant in the evaluation of these cysts. Case: Herein we report a case of perineural cyst misdiagnosed with hydrosalpinx by pelvic ultrasonography and finally diagnosed with magnetic resonance image...
September 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29661400/corrigendum-to-perineural-dexamethasone-the-dilemma-of-systematic-reviews-and-meta-analyses-br-j-anaesth-2018-120-201-203
#12
P Marhofer, M Columb, P M Hopkins
No abstract text is available yet for this article.
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29660549/perineural-spread-along-spinal-and-obturator-nerves-in-primary-vaginal-carcinoma-a-case-report
#13
Eun Jee Song, Ji Seon Park, Kyung Nam Ryu, So Young Park, Wook Jin
BACKGROUND: Perineural spread is not uncommon feature in carcinoma of the head and neck. On the contrary, perineural spread in pelvic malignancies has been rarely reported. This report is the first report about perineural spread of obturator nerve and lumbosacral plexus from primary vaginal cancer. CASE DESCRIPTION: A 50-year-old woman diagnosed with infectious spondylitis at an outside hospital was referred to our institution. She presented with persistent lower back pain and right anterior thigh pain...
April 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29659424/utility-of-magnetic-resonance-imaging-for-predicting-severity-of-sciatic-nerve-injury
#14
Shivani Ahlawat, Allan J Belzberg, Laura M Fayad
OBJECTIVE: This study aimed to investigate the diagnostic accuracy of magnetic resonance (MR) imaging for categorizing sciatic peripheral nerve injury (PNI) as high-grade (Sunderland grades IV-V) or low-grade (Sunderland grades I-III) PNI. METHODS: In this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study, consecutive MR imaging of the pelvis and thighs, performed for the evaluation of traumatic sciatic neuropathy, was reviewed for sciatic nerve signal intensity, size, architectural distortion, bulbous enlargement, perineural fibrosis, discontinuity, and muscle denervation changes...
April 13, 2018: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29658680/rectal-cancer-and-the-pathologist
#15
Mariana Berho, Pablo A Bejarano
INTRODUCTION: Examination of the rectum by pathologists is instrumental in the management of patients affected by rectal carcinoma. That role includes evaluation of multiple gross and microscopic features that convey prognostic implications. EVIDENCE ACQUISITION: The analysis is based on the authors' experience handling rectal specimens along with review of the pertinent literature in these areas: margins of excision, quality of the mesorectum, diligence and techniques to sample lymph nodes, tumor budding, grading of residual amount of carcinoma after pre-operative therapy, vascular/perineural invasion, and staging the tumor...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29630032/perineural-versus-systemic-dexamethasone-in-front-foot-surgery-under-ankle-block-a-randomized-double-blind-study
#16
Philippe Marty, Olivier Rontes, Clément Chassery, Corine Vuillaume, Bertrand Basset, Mehdi Merouani, Constance Marquis, Benoit Bataille, Martine Chaubard, Marie Claude Mailles, Fabrice Ferré, Alain Delbos
BACKGROUND AND OBJECTIVES: Among the different adjuvants, dexamethasone is one of the most accepted to prolong the effect of local anesthetics. This study aims to determine the superiority of perineural over systemic dexamethasone administration after a single-shot ankle block in metatarsal osteotomy. METHODS: We performed a prospective, double-blind, randomized study. A total of 100 patients presenting for metatarsal osteotomy with an ankle block were randomized into 2 groups: 30 mL ropivacaine 0...
April 6, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29628577/comparison-of-dexamethasone-and-buprenorphine-as-adjuvant-in-ultrasound-guided-brachial-plexus-blocks-a-randomized-controlled-trial
#17
Prasanna Vadhanan, Narendren Ganesh, M I Hussain Ahmed
Introduction: Effective postoperative analgesia is imperative for orthopedic surgeries to enhance recovery and facilitate early ambulation. Various additives have been used as adjuvants with local anesthetics in peripheral nerve blocks to provide postoperative analgesia. The aim of this study is to compare the duration of postoperative analgesia with buprenorphine and dexamethasone when administered as an adjuvant during ultrasound-guided brachial plexus blocks. Methodology: Sixty adult patients undergoing various upper arm surgeries were recruited for the study after acquiring ethics committee clearance...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29627047/biology-of-adenoid-cystic-carcinoma-of-the-tracheobronchial-tree-and-principles-of-management
#18
REVIEW
Donna E Maziak
Adenoid cystic carcinoma of the trachea is a rare tumor. The mainstay of treatment remains surgical resection, even in the presence of positive margins or metastatic disease. Perineural involvement commonly causes positive margins and should not deter from resection. Knowledge of releasing maneuvers is essential for surgical success. Long-term follow-up is required with patients presenting late and surviving with recurrent disease for years.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29624511/poorly-differentiated-clusters-predict-colon-cancer-recurrence-an-in-depth-comparative-analysis-of-invasive-front-prognostic-markers
#19
Tsuyoshi Konishi, Yoshifumi Shimada, Lik Hang Lee, Marcela S Cavalcanti, Meier Hsu, Jesse Joshua Smith, Garrett M Nash, Larissa K Temple, José G Guillem, Philip B Paty, Julio Garcia-Aguilar, Efsevia Vakiani, Mithat Gonen, Jinru Shia, Martin R Weiser
This study aimed to compare common histologic markers at the invasive front of colon adenocarcinoma in terms of prognostic accuracy and interobserver agreement. Consecutive patients who underwent curative resection for stages I to III colon adenocarcinoma at a single institution in 2007 to 2014 were identified. Poorly differentiated clusters (PDCs), tumor budding, perineural invasion, desmoplastic reaction, and Crohn-like lymphoid reaction at the invasive front, as well as the World Health Organization (WHO) grade of the entire tumor, were analyzed...
April 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29623587/postoperative-intra-abdominal-infection-is-an-independent-prognostic-factor-of-disease-free-survival-and-disease-specific-survival-in-patients-with-stage-ii-colon-cancer
#20
P Sánchez-Velázquez, M Pera, M Jiménez-Toscano, X Mayol, X Rogés, L Lorente, M Iglesias, M Gallén
BACKGROUND: Recurrence occurs in up to 20% of patients with stage II colon cancer operated on for cure. Although postoperative intra-abdominal infection has been linked with an increased risk of recurrence, the association is controversial. The aim was to investigate the impact of postoperative intra-abdominal infection on disease-free survival and disease-specific survival in patients with stage II colon cancer. METHODS: Patients undergoing elective surgery for colon cancer stage II, between 2003 and 2014, were included...
April 5, 2018: Clinical & Translational Oncology
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