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https://www.readbyqxmd.com/read/28735439/surgical-management-of-periocular-cancers-high-and-low-risk-features-drive-treatment
#1
REVIEW
Richard C Allen
PURPOSE OF REVIEW: Recent advances in the treatment of eyelid tumors have centered on the excision, evaluation of margins, role of sentinel lymph node biopsy, and adjunctive/adjuvant systemic and radiation therapy. The purpose of this review is to elaborate on these advances. RECENT FINDINGS: Mohs excision of basal cell carcinoma and squamous cell carcinoma continues to provide the greatest success in complete excision of the cancer, especially in those cases of high-risk disease including medial canthal location and recurrent disease...
September 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28734009/kit-mutations-and-cd117-overexpression-are-markers-of-better-progression-free-survival-in-vulvar-melanomas
#2
D Dias-Santagata, M A Selim, Y Su, Y Peng, R Vollmer, A Chłopik, G T Marti, K Paral, S Shalin, C R Shea, S Puig, M T Fernandez-Figueras, W Biernat, J Ryś, A Marszalek, M P Hoang
BACKGROUND: Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas. OBJECTIVES AND METHODS: We evaluated the clinicopathologic features of 95 cases. p53, CD117, Ki-67, neurofibromin, brafv600e, and nrasq61r immunostains; and molecular analyses by either targeted next generation or direct sequencing were performed on available archival materials. RESULTS: Molecular testing detected mutations in KIT (44%), BRAF (25%), NF1 (22%), TP53 (17%), NRAS (9%), and TERT promoter (9%)...
July 22, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28725617/post-vasectomy-pain-syndrome-diagnosis-management-and-treatment-options
#3
REVIEW
Varsha Sinha, Ranjith Ramasamy
Vasectomy is the most effective form of sterilization for men. With approximately 500,000 vasectomies performed each year in the United States, 1-2% of these patients will experience chronic testicular pain for greater than three months after the procedure. Post-vasectomy pain syndrome (PVPS) is diagnosis of exclusion, and may be caused by direct damage to spermatic cord structures, compression of nerves in the spermatic cord via inflammation, back pressure from epididymal congestion, and perineural fibrosis...
May 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725616/chronic-orchialgia-epidemiology-diagnosis-and-evaluation
#4
REVIEW
John T Sigalos, Alexander W Pastuszak
Chronic orchialgia is a vexing condition defined as chronic or intermittent scrotal pain lasting at least three months that significantly interferes with daily activities. There are currently no guidelines regarding the diagnosis and management of this condition despite it being the cause of 2.5-4.8% of urologic clinic visits. Men often present with chronic orchialgia in their mid to late 30s, although the condition can present at any age. A broad differential diagnosis of chronic orchialgia includes epididymitis, testicular torsion, tumors, obstruction, varicocele, epididymal cysts, hydrocele, iatrogenic injury following vasectomy or hernia repair, and referred pain from a variety of sources including mid-ureteral stone, indirect inguinal hernia, aortic or common iliac artery aneurysms, lower back disorders, interstitial cystitis, and nerve entrapment due to perineural fibrosis; approximately 25-50% of chronic orchialgia is idiopathic in nature...
May 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28724272/patients-characteristics-histopathological-findings-and-tumor-stage-in-different-types-of-malignant-melanoma-a-retrospective-multicenter-study
#5
Ali-Mohammad Farahmand, Amir-Hoshang Ehsani, Mojtaba Mirzaei, Maryam Mohsenian, Alireza Ghanadan
Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histopathological findings. In this retrospective study, we obtained our data from the records of 111 patients with melanoma...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724267/association-of-neo-angiogenesis-by-cd34-expression-and-clinicopathologic-features-in-squamous-cell-carcinoma-of-cervix
#6
Soheila Sarmadi, Narges Izadi-Mood, Fatemeh Movarei, Salma Sefidbakht, Kambiz Sotoudeh, Eesa Jahanzad
Tumor angiogenesis is one of the most important factors in tumor progression. In this study, the angiogenesis of cervical squamous cell carcinoma (SCC) and its association with prognostic factors was assessed by using CD34 immunostaining marker. The microvessel density in 40 patients with cervical SCC was studied in three areas of the tumor; stromal and peripheral tumor area (combined) central stromal tumor area and peripheral tumor area and the relationship of microvascular density and survival was also evaluated...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28720393/maxillary-nerve-blocks-in-horses-an-experimental-comparison-of-surface-landmark-and-ultrasound-guided-techniques
#7
Stephanie Stauffer, Beckie Cordner, Jonathon Dixon, Thomas Witte
OBJECTIVE: The aim of this preliminary proof-of-concept study was to evaluate and compare the success and complication rate of infiltration of the maxillary nerve of cadaver heads using previously described surface landmarks, standard ultrasound and a novel needle guidance positioning ultrasound system (SonixGPS). STUDY DESIGN: Prospective, anatomical, method-comparison study. ANIMALS: Thirty-eight equine cadaver heads. METHODS: Twenty-six veterinary students performed the three methods consecutively on cadaver heads using an 18 gauge, 8...
April 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28715356/a-mouse-model-for-pain-and-neuroplastic-changes-associated-with-pancreatic-ductal-adenocarcinoma
#8
Deepitha Selvaraj, Michael Hirth, Jagadeesh Gandla, Rohini Kuner
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the deadliest human malignancies and is associated with excruciating pain, which is a serious complication and severely impacts the quality of life in patients. In human patients, poor survival prognosis is linked to remarkable remodeling of intrapancreatic nerves, which, in turn, is correlated to increased pain intensity. Understanding mechanisms underlying pain associated with PDAC has been hampered by the lack of animal models which replicate all germane aspects of the disease and importantly, enable analyses of pain associated with PDAC...
August 2017: Pain
https://www.readbyqxmd.com/read/28707326/perineural-invasion-present-exclusively-in-central-tissue-blocks-of-mohs-surgical-excisions-of-basal-cell-carcinoma
#9
Lauren Young, Dougal Coates, John Pagliaro, David Francis, Richard Williamson, Zoran Gaspar
Perineural invasion (PNI) may be present in basal cell carcinomas (BCC) treated with Mohs micrographic surgery. This single-centre, non-randomised, prospective study demonstrates the potential for PNI to exist exclusively within the central tissue blocks of Mohs specimens.
July 14, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28706767/surgical-excision-of-a-symptomatic-thoracic-nerve-root-perineural-cyst-resulting-in-complete-resolution-of-symptoms-a-case-report
#10
Zaid Aljuboori, Alae Yaseen, Jessica Simpson, Maxwell Boakye
Tarlov (perineural) cysts of the nerve root are common and usually incidental findings during magnetic resonance imaging (MRI) of the lumbosacral spine. There are a few case reports where symptomatic thoracic perineural cysts have been described in the literature. We report a case of a high thoracic nerve root perineural cyst that failed conservative therapy, requiring surgical intervention. Our patient presented with radicular symptoms involving the left hand. Imaging workup revealed a cystic lesion of the left T1 nerve root at the level of the foramen...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28705708/perineural-invasion-by-prostate-cancer-on-mr-us-fusion-targeted-biopsy-is-associated-with-extraprostatic-extension-and-early-biochemical-recurrence-after-radical-prostatectomy
#11
Matthew Truong, Soroush Rais-Bahrami, Jeffrey W Nix, Edward M Messing, Hiroshi Miyamoto, Jennifer B Gordetsky
In recent years, multiparametric magnetic resonance imaging (MRI) and MR/ultrasound (US) fusion targeted biopsy (TB) have become more widely adopted to aid in prostate cancer (PCa) detection. Previously, TB has been found to increase the yield of clinically significant PCa and is more likely to sample the index tumor compared to traditional 12-core extended sextant biopsies. Currently the prognostic significance of perineural invasion (PNI) when identified on TB (PNI-TB) is unknown. We identified 95 men at two tertiary referral centers who underwent TB followed by radical prostatectomy between January 2014 and January 2017...
July 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28703891/duration-of-action-of-mepivacaine-and-lidocaine-in-equine-palmar-digital-perineural-blocks-in-an-experimental-lameness-model
#12
Mona Hoerdemann, Rachael L Smith, Giselle Hosgood
OBJECTIVE: To establish and compare the onset and duration of action of 2 local anesthetics based on objective lameness and skin sensitivity assessment. STUDY DESIGN: Interventional crossover experimental trial with balanced randomization. ANIMALS: Eight horses. METHODS: Reversible forelimb lameness was induced in 8 horses. A palmar digital nerve block (PDNB) was applied with mepivacaine or lidocaine (both 2%). Quantitative lameness and skin sensitivity data were collected with an inertial sensor system and a force gauge, respectively...
July 13, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28702948/pathological-prognostic-factors-of-recurrence-in-early-stage-lung-adenocarcinoma
#13
Eunjue Yi, Mi-Kyeong Bae, Sukki Cho, Jin-Haeng Chung, Sanghoon Jheon, Kwhanmien Kim
BACKGROUND: Histological heterogeneity is thought to be important for prognosis of lung adenocarcinoma. We investigated to determine pathological features with prognostic value for recurrence of early stage lung cancer. METHODS: A total of 368 patients who underwent curative surgical resection for early stage lung adenocarcinoma between 2009 and 2012 were enrolled. Pathologic characteristics including the presence of visceral pleural invasion, micropapillary patterns, aerogenous spread, lymphovascular invasion, perineural invasion and necrosis were examined...
July 12, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28700327/endoplasmic-reticulum-aminopeptidase-2-involvement-in-metastasis-of-oral-cavity-squamous-cell-carcinoma-discovered-by-proteome-profiling-of-primary-cancer-cells
#14
I-Chun Kuo, Huang-Kai Kao, Yenlin Huang, Chun-I Wang, Jui-Shan Yi, Ying Liang, Chun-Ta Liao, Tzu-Chen Yen, Chih-Ching Wu, Kai-Ping Chang
Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an OSCC-associated protein. Compared with the adjacent normal tissues, ERAP2 levels were determined to be significantly elevated in OSCC tissues using quantitative real-time PCR and immunohistochemistry...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699141/epi-perineural-and-schwann-cells-as-well-as-perineural-sheath-integrity-are-affected-following-2-4-d-exposure
#15
Marzieh Sharifi Pasandi, Farshad Hosseini Shirazi, Mohammad Reza Gholami, Hossein Salehi, Nowruz Najafzadeh, Mohammad Mazani, Hatef Ghasemi Hamidabadi, Ali Niapour
2,4-dicholorophenoxy acetic acid (2,4-D) is a worldwide-known hormone herbicide. However, there are increasing concerns about its exposure and risks of developing pathological conditions for the peripheral nervous system. The aim of this study was to investigate the mechanism(s) involved in the toxicity of 2,4-D on peripheral nerve's cellular components. The epi/perineural and Schwann cells and a total of three cell lines were treated with 2,4-D. The viability of cells at different doses of 2,4-D was measured by MTT assay...
July 11, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28688636/utilization-and-impact-of-adjuvant-chemotherapy-among-patients-with-resected-stage-ii-colon-cancer-a-multi-institutional-analysis
#16
Aslam Ejaz, Leigh Casadaban, Ajay V Maker
BACKGROUND: The use of chemotherapy among patients with stage II colon cancer is controversial. We aimed to define the utilization and factors associated with the receipt of chemotherapy and the impact of chemotherapy on long-term prognosis among a large, multiinstitutional cohort of patients. MATERIALS AND METHODS: We identified 876 patients who underwent resection for stage II colon cancer between 2004 and 2013 at one of seven participating institutions. Overall survival (OS) and recurrence-free survival (RFS) time was calculated from the date of the index procedure to the date of death...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688621/ultrasound-guided-perineural-injection-with-platelet-rich-plasma-improved-the-neurophysiological-parameters-of-carpal-tunnel-syndrome-a-case-report
#17
Ying-Chen Kuo, Chia-Cheng Lee, Lin-Fen Hsieh
Carpal tunnel syndrome (CTS) is a common and sometimes challenging condition, which causes pain; paresthesia; tingling of the thumb, index and long fingers; and even thenar weakness in the hands. The effectiveness of corticosteroid injections seems to be transient, and there is a lack of information around long-term effects in previous studies. In recent years, platelet-rich plasma (PRP) has proven to bean alternative as it encourages tissue regeneration. We hereby describe a patient with CTS showing significant improvements in electrophysiological parameters after receiving PRP injections...
July 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28687431/resectable-invasive-ipmn-versus-sporadic-pancreatic-adenocarcinoma-of-the-head-of-the-pancreas-should-these-two-different-diseases-receive-the-same-treatment-a-matched-comparison-study-of-the-french-surgical-association-afc
#18
P Duconseil, J Périnel, A Autret, M Adham, A Sauvanet, L Chiche, J-Y Mabrut, J-J Tuech, C Mariette, N Régenet, J-M Fabre, P Bachellier, J-R Delpéro, F Paye, O Turrini
PURPOSE: To compare survival and impact of adjuvant chemotherapy in patients who underwent pancreaticoduodenectomy (PD) for invasive intraductal papillary mucinous neoplasm (IIPMN) and sporadic pancreatic ductal adenocarcinoma (PDAC). METHODS: From 2005 to 2012, 240 patients underwent pancreatectomy for IIPMN and 1327 for PDAC. Exclusion criteria included neoadjuvant treatment, pancreatic resection other than PD, vascular resection, carcinoma in situ, or <11 examined lymph nodes...
June 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28683511/-extracranial-schwannomas-of-the-head-and-neck-clinical-approach-based-on-20-cases
#19
Benedikt Höing, Boris A Stuck, Benjamin Kansy, Timon Hussain, Anke Schlüter, Laura Holtmann, Adrian Ringelstein, Stefan Mattheis, Stephan Lang, Nina Dominas
Background Schwannomas are rare benign tumors originating from the perineural cells forming the myelin layer in the peripheral nervous system (PNS). While well established therapeutic concepts exist for intracranial schwannomas, there is a lack of consistent clinical standards for extracranial schwannomas. Method This retrospective study describes the clinical pathway of 20 patients with histologically proven extracranial schwannomas of the head and neck. The diagnostic and therapeutic strategies for schwannomas are discussed with special emphasis on localization and functional outcome...
July 6, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28682892/in-patients-undergoing-fast-track-total-knee-arthroplasty-addition-of-buprenorphine-to-a-femoral-nerve-block-has-no-clinical-advantage-a-prospective-double-blinded-randomized-placebo-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Rienk van Beek, Harry J Zonneveldt, Tjeerd van der Ploeg, Jeroen Steens, Phillip Lirk, Marcus W Hollmann
BACKGROUND: Several adjuvants have been proposed to prolong the effect of peripheral nerve blocks, one of which is buprenorphine. In this randomized double blinded placebo controlled trial we studied whether the addition of buprenorphine to a femoral nerve block prolongs analgesia in patients undergoing total knee arthroplasty in a fast track surgery protocol. METHODS: The treatment group (B) was given an ultrasound-guided femoral nerve block with ropivacaine 0...
July 2017: Medicine (Baltimore)
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