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Adjacent Segment

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https://www.readbyqxmd.com/read/28723757/comprehensive-comparing-percutaneous-endoscopic-lumbar-discectomy-with-posterior-lumbar-internal-fixation-for-treatment-of-adjacent-segment-lumbar-disc-prolapse-with-stable-retrolisthesis-a-retrospective-case-control-study
#1
Yapeng Sun, Wei Zhang, Suhui Qie, Nan Zhang, Wenyuan Ding, Yong Shen
The study was to comprehensively compare the postoperative outcome and imaging parameter characters in a short/middle period between the percutaneous endoscopic lumbar discectomy (PELD) and the internal fixation of bone graft fusion (the most common form is posterior lumbar interbody fusion [PLIF]) for the treatment of adjacent segment lumbar disc prolapse with stable retrolisthesis after a previous lumbar internal fixation surgery.In this retrospective case-control study, we collected the medical records from 11 patients who received PELD operation (defined as PELD group) for and from 13 patients who received the internal fixation of bone graft fusion of lumbar posterior vertebral lamina decompression (defined as control group) for the treatment of the lumbar disc prolapse combined with stable retrolisthesis at Department of Spine Surgery, the Third Hospital of Hebei Medical University (Shijiazhuang, China) from May 2010 to December 2015...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723737/how-to-choose-when-implants-of-adjacent-height-both-fit-the-disc-space-properly-in-single-level-cervical-artificial-disc-replacement
#2
Xin Rong, Jigang Lou, Huibo Li, Yang Meng, Hao Liu
In cervical artificial disc replacement (C-ADR), sometimes we encountered with such cases that implants of adjacent height both fit the target disc space properly. No study was available discussing the choice of implant height and the clinical outcomes under such circumstance. The purpose of this study was to evaluate the impact of different implant heights on the clinical outcomes and radiographic results when the implants of adjacent height both fit the disc space properly. This retrospective study included 34 patients underwent single-level C-ADR at the C5-C6 level at our institution...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28718168/higher-reoperation-rate-following-cervical-disc-replacement-in-a-retrospective-long-term-comparative-study-of-715-patients
#3
Martin Skeppholm, Thomas Henriques, Tycho Tullberg
PURPOSE: To evaluate rates of secondary surgical interventions in a cohort treated with fusion (ACDF), artificial disc replacement (ADR) or a posterior surgical procedure (PP) because of a cervical degenerative pathology. METHODS: 715 patients treated with any primary cervical surgical intervention between the years 2000 and 2010 were retrospectively evaluated regarding frequency of secondary surgery between the years 2000 and 2015, thus giving a follow-up time of minimum 5 years...
July 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28713734/treatment-of-micrognathia-by-intraoral-distraction-osteogenesis-a-prospective-study
#4
M Baskaran, S Gidean Arularasan, T K Divakar, Rohini Thirunavukkarasu
PURPOSE: Maxillofacial deformities are always psychologically and physically distressing to the patients and is also challenging to the treating surgeons. The term Micrognathia means a "small jaw". True micrognathia, where the maxilla or the mandibular skeleton does not grow to the full size can be congenital or acquired. Distraction osteogenesis also called as callus distraction or callostasis or osteodistraction or distraction histogenesis is a biological process of regenerating newly formed bone and adjacent soft tissue by a gradual and controlled traction of surgically separated bone segments...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28708823/notch-dependent-epithelial-fold-determines-boundary-formation-between-developmental-fields-in-the-drosophila-antenna
#5
Hui-Yu Ku, Y Henry Sun
Compartment boundary formation plays an important role in development by separating adjacent developmental fields. Drosophila imaginal discs have proven valuable for studying the mechanisms of boundary formation. We studied the boundary separating the proximal A1 segment and the distal segments, defined respectively by Lim1 and Dll expression in the eye-antenna disc. Sharp segregation of the Lim1 and Dll expression domains precedes activation of Notch at the Dll/Lim1 interface. By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold...
July 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28700452/the-surgical-treatment-of-cervical-radiculopathy-meta-analysis-of-randomized-controlled-trials
#6
Gabriel Gutman, Derek H Rosenzweig, Jeff D Golan
STUDY DESIGN: Meta-analysis of published randomized controlled trials (RCTs). OBJECTIVE: To determine whether anterior cervical discectomy and fusion (ACDF), cervical disc replacement (CDR) or minimally invasive posterior cervical foraminotomy (MI-PCF) provides the best outcomes for patients with symptomatic single-level, single-side, cervical radiculopathy. SUMMARY OF BACKGROUND DATA: The surgical treatment of cervical radiculopathy is still controversial...
July 11, 2017: Spine
https://www.readbyqxmd.com/read/28700215/roles-of-transport-limitations-and-mineral-heterogeneity-in-carbonation-of-fractured-basalts
#7
Anne Holland Menefee, Peiyuan Li, Daniel E Giammar, Brian R Ellis
Basalt formations could enable secure long-term carbon storage by trapping injected CO2 as stable carbonates. Here, a predictive modeling framework was designed to evaluate the roles of transport limitations and mineral spatial distributions on mineral dissolution and carbonation reactions in fractured basalts exposed to CO2-acidified fluids. Reactive transport models were developed in CrunchTope based on data from high-temperature, high-pressure flow-through experiments. Models isolating the effect of transport compared nine flow conditions under the same mineralogy...
July 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28698661/the-non-bilayer-lipid-mgdg-stabilizes-the-major-light-harvesting-complex-lhcii-against-unfolding
#8
Dennis Seiwert, Hannes Witt, Andreas Janshoff, Harald Paulsen
In the photosynthetic apparatus of plants a high proportion of LHCII protein is needed to integrate 50% non-bilayer lipid MGDG into the lamellar thylakoid membrane, but whether and how the stability of the protein is also affected is not known. Here we use single-molecule force spectroscopy to map the stability of LHCII against mechanical unfolding along the polypeptide chain as a function of oligomerization state and lipid composition. Comparing unfolding forces between monomeric and trimeric LHCII demonstrates that the stability does not increase significantly upon trimerization but can mainly be correlated with specific contact sites between adjacent monomers...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698278/on-the-origin-of-reverse-transcriptase-using-crispr-cas-systems-and-their-hyperdiverse-enigmatic-spacer-repertoires
#9
Sukrit Silas, Kira S Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R Krishnamurthy, Becky Xu Hua Fu, Loren L Hansen, David Wang, Matthew B Sullivan, Andrew Millard, Martha R Clokie, Devaki Bhaya, Alan M Lambowitz, Nikos C Kyrpides, Eugene V Koonin, Andrew Z Fire
Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse transcriptase (RT) related to group II intron RTs. An RT-Cas1 fusion protein has been recently shown to enable acquisition of CRISPR spacers from RNA. Phylogenetic analysis of the CRISPR-associated RTs demonstrates monophyly of the RT-Cas1 fusion, and coevolution of the RT and Cas1 domains...
July 11, 2017: MBio
https://www.readbyqxmd.com/read/28693562/activation-of-the-alpha-globin-gene-expression-correlates-with-dramatic-upregulation-of-nearby-non-globin-genes-and-changes-in-local-and-large-scale-chromatin-spatial-structure
#10
Sergey V Ulianov, Aleksandra A Galitsyna, Ilya M Flyamer, Arkadiy K Golov, Ekaterina E Khrameeva, Maxim V Imakaev, Nezar A Abdennur, Mikhail S Gelfand, Alexey A Gavrilov, Sergey V Razin
BACKGROUND: In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making their expression comparable to the rRNA transcriptional output. Little is known about the influence of the erythroid-specific alpha-globin gene transcription outburst on adjacent, widely expressed genes and large-scale chromatin organization. Here, we have analyzed the total transcription output, the overall chromatin contact profile, and CTCF binding within the 2...
July 11, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28692568/superior-segment-facet-joint-violation-during-instrumented-lumbar-fusion-is-associated-with-higher-reoperation-rates-and-diminished-improvement-in-quality-of-life
#11
Jay M Levin, Vincent J Alentado, Andrew T Healy, Michael P Steinmetz, Edward C Benzel, Thomas E Mroz
STUDY DESIGN: A retrospective cohort study at a single tertiary care center. OBJECTIVE: To determine the impact of superior segment facet joint violation (FJV) during lumbar fusion on reoperation rates and quality of life (QOL). SUMMARY OF BACKGROUND DATA: Although lumbar fusion is an efficacious and durable treatment for numerous spinal pathologies, adjacent segment degeneration remains a serious complication. FJV has been suggested to alter load-bearing capability and potentially contribute to adjacent segment degeneration...
July 7, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28689737/asymmetrically-deployed-actomyosin-based-contractility-generates-a-boundary-between-developing-leg-segments-in-drosophila
#12
Dan Ly, Erin Resch, George Ordiway, Stephen DiNardo
The formation of complex tissues from simple epithelial sheets requires the regional subdivision of the developing tissue. This is initially accomplished by a sequence of gene regulatory hierarchies that set up distinct fates within adjacent territories, and rely on cross-regulatory interactions to do so. However, once adjacent territories are established, cells that confront one another across territorial boundaries must actively participate in maintaining separation from each other. Classically, it was assumed that adhesive differences would be a primary means of sorting cells to their respective territories...
July 6, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28687502/endovascular-treatment-of-distal-tears-located-in-the-reno-viseceral-segment-with-bare-metal-stents-and-coils-in-a-complicated-type-b-aortic-dissection
#13
Qingsheng Lu, Yanqing Chen, Yongxue Zhang, Hongfei Wang, Hanyan Li, Jiaxuan Feng, Huajuan Mao, Zaiping Jing
PURPOSE: To provide an endovascular strategy of treating patent re-entries adjacent to visceral branches in the management of aortic dissections. CASE REPORT: A 45-year-old male who had received endovascular treatment for a type B aortic dissection was again admitted for his intermittent abdominal pain. Distal tears located in the reno-visceral segment was left untreated in the initial procedure, and was thought to be related to the expansion of the false lumen during follow-up...
July 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28681193/bone-spect-ct-in-the-postoperative-spine-a-focus-on-spinal-fusion
#14
REVIEW
Khulood Al-Riyami, Gopinath Gnanasegaran, Tim Van den Wyngaert, Jamshed Bomanji
Low back pain is a global problem affecting one in 10 people. The management of low back pain varies from conservative to more invasive methods with a spectacular increase in the number of patients undergoing spinal fusion surgery during the last decade. Conventional radiological and radionuclide studies are often used in the assessment of persistent or recurring pain after spinal surgery with several advantages and limitations related to each technique. This article reviews the key contribution of integrated bone SPECT/CT in evaluating patients with persistent or recurring pain after spinal surgery, focusing on spinal fusion...
July 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28678112/prosthesis-and-hybrid-strategy-consideration-for-treating-2-level-cervical-disc-degeneration-in-hybrid-surgery
#15
Yang Li, Guy R Fogel, Zhenhua Liao, Rajnesh Tyagi, Weiqiang Liu
STUDY DESIGN: Biomechanical analysis using a validated nonlinear finite element (FE) model. OBJECTIVE: To combine the strategy of two-level hybrid surgery (HS) to explore how prostheses affect cervical biomechanics. SUMMARY OF BACKGROUND DATA: Few FE studies have explored differences in biomechanical behavior between combined and stand-alone structured prostheses with HS. No FE studies have considered whether the prosthesis type and hybrid strategy influence two-level HS...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28678106/proper-responding-strategies-to-neuromonitoring-alerts-during-correction-step-in-posterior-vertebral-column-resection-patients-with-severe-rigid-deformities-can-reduce-postoperative-neurologic-deficits
#16
Yingsong Wang, Jingming Xie, Zhi Zhao, Tao Li, Ni Bi, Ying Zhang, Zhiyue Shi
STUDY DESIGN: Retrospective study. OBJECTIVE: To analyze the intraoperative neuromonitoring (IOM) changes in posterior vertebral column resection (PVCR) for severe rigid deformity patients, and describe our stepwise responding strategies. SUMMARY OF BACKGROUND DATA: Obvious neurological deficit risk accompanied with PVCR correction has been emphasized repeatedly. METHODS: The records of 46 PVCR patients achieved IOM were reviewed...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28676980/clinical-and-radiological-outcome-at-10-years-of-follow-up-after-total-cervical-disc-replacement
#17
Christoph Mehren, Franziska Heider, Christoph J Siepe, Bernhard Zillner, Ralph Kothe, Andreas Korge, H Michael Mayer
PURPOSE: Previous studies have demonstrated that total cervical disc replacement (cTDR) represents a viable treatment alternative to the 'gold standard' anterior cervical discectomy and fusion for the treatment of well-defined cervical pathologies at short- and mid-term follow-up (FU). However, the implementation and acceptance of a non-fusion philosophy is closely associated with its avoidance of adjacent segment degeneration. Proof of the functional sustainability and clinical improvement of symptoms at long-term FU is still pending...
July 4, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28673830/motion-preservation-following-total-lumbar-disc-replacement-at-the-lumbosacral-junction-a-prospective-long-term-clinical-and-radiographic-investigation
#18
Christoph Wuertinger, Raphael Dàgostino Annes, Wolfgang Hitzl, Christoph J Siepe
BACKGROUND CONTEXT: Total lumbar disc replacement (TDR) intends to avoid fusion related negative side effects by means of motion preservation. Despite of their widespread use, the adequate quality and quantity of motion as well as the correlation between radiographic data with the patient's clinical symptomatology remains to be established. Long-term data are lacking in particular. PURPOSE: To perform a clinical and radiographic long-term investigation following TDR with special emphasis on motion preservation assessment and to establish any potential correlation with patient reported outcome parameters...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28673829/lumbar-spine-surgery-in-patients-with-rheumatoid-arthritis-ra-what-affects-the-outcomes
#19
Shoji Seki, Norikazu Hirano, Isao Matsushita, Yoshiharu Kawaguchi, Masato Nakano, Taketoshi Yasuda, Hiraku Motomura, Kayo Suzuki, Yasuhito Yahara, Kenta Watanabe, Hiroto Makino, Tomoatsu Kimura
BACKGROUND CONTEXT: While the cervical spine is only occasionally involved in rheumatoid arthritis (RA), involvement of the lumbar spine is even less common. A few reports on lumbar spinal stenosis in patients with RA have appeared. Although disc space narrowing occurs in aging, postoperative ASD in RA patients has not been subject to much analysis. PURPOSE: To investigate differences in adjacent segment disease (ASD) and clinical outcomes between lumbar spinal decompression with and without fusion in patients with rheumatoid arthritis (RA)...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28670415/outcomes-of-revision-surgery-following-instrumented-posterolateral-fusion-in-degenerative-lumbar-spinal-stenosis-a-comparative-analysis-between-pseudarthrosis-and-adjacent-segment-disease
#20
Seung-Pyo Suh, Young-Hoon Jo, Hae Won Jeong, Won Rak Choi, Chang-Nam Kang
STUDY DESIGN: Retrospective study. PURPOSE: We examined the clinical and radiological outcomes of patients who received revision surgery for pseudarthrosis or adjacent segment disease (ASD) following decompression and instrumented posterolateral fusion (PLF). OVERVIEW OF LITERATURE: At present, information regarding the outcomes of revision surgery for complications such as pseudarthrosis and ASD following instrumented PLF is limited. METHODS: This study examined 60 patients who received PLF for degenerative lumbar spinal stenosis and subsequently developed pseudarthrosis or ASD leading to revision surgery...
June 2017: Asian Spine Journal
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