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Adjacent Segment

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https://www.readbyqxmd.com/read/28635102/ratiometric-analysis-of-optical-coherence-tomography-measured-in%C3%A2-vivo-retinal-layer-thicknesses-for-the-detection-of-early-diabetic-retinopathy
#1
Basanta Bhaduri, Ryan L Shelton, Ryan M Nolan, Lucas Hendren, Alexandra Almasov, Leanne T Labriola, Stephen A Boppart
Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i. e...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28634160/high-throughput-characterization-of-cascade-type-i-e-crispr-guide-efficacy-reveals-unexpected-pam-diversity-and-target-sequence-preferences
#2
Becky Xu Hua Fu, Michael Wainberg, Anshul Kundaje, Andrew Z Fire
Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are transcribed and processed to produce small CRISPR RNAs (crRNAs), with degradation of invading genetic material directed by a combination of complementarity between RNA and DNA and in some cases recognition of adjacent motifs called PAMs (Protospacer Adjacent Motifs)...
June 20, 2017: Genetics
https://www.readbyqxmd.com/read/28633196/tight-junction-strand-formation-by-claudin-10-isoforms-and-claudin-10a-10b-chimeras
#3
Susanne Milatz, Jörg Piontek, Caroline Hempel, Luca Meoli, Christoph Grohe, Anja Fromm, In-Fah M Lee, Rukeia El-Athman, Dorothee Günzel
Claudins are integral components of tight junctions (TJs) in epithelia and endothelia. When expressed in cell lines devoid of TJs, claudins are able to form TJ-like strands at contacts between adjacent cells. According to a current model of TJ strand formation, claudin protomers assemble in an antiparallel double row within the plasma membrane of each cell (cis-interaction) while binding to corresponding double rows from the neighboring cells (trans-interaction). Cis-interaction was proposed to involve two interfaces of the protomers' first extracellular segment (extracellular loop (ECL)1)...
June 20, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28632563/why-lumbar-artificial-disk-replacements-ladrs-fail
#4
Kenneth Pettine, Robert Ryu, Fernando Techy
STUDY DESIGN: A retrospective review of prospectively collected data. OBJECTIVE: To determine why artificial disk replacements (ADRs) fail by examining results of 91 patients in FDA studies performed at a single investigational device exemption (IDE) site with minimum 2-year follow-up. SUMMARY OF BACKGROUND DATA: Patients following lumbar ADR generally achieve their 24-month follow-up results at 3 months postoperatively. MATERIALS AND METHODS: Every patient undergoing ADR at 1 IDE site by 2 surgeons was evaluated for clinical success...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28629355/biologically-constrained-optimization-based-cell-membrane-segmentation-in-c-elegans-embryos
#5
Yusuke Azuma, Shuichi Onami
BACKGROUND: Recent advances in bioimaging and automated analysis methods have enabled the large-scale systematic analysis of cellular dynamics during the embryonic development of Caenorhabditis elegans. Most of these analyses have focused on cell lineage tracing rather than cell shape dynamics. Cell shape analysis requires cell membrane segmentation, which is challenging because of insufficient resolution and image quality. This problem is currently solved by complicated segmentation methods requiring laborious and time consuming parameter adjustments...
June 19, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28625479/the-change-of-adjacent-segment-after-cervical-disc-arthroplasty-compared-with-anterior-cervical-discectomy-and-fusion-a-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Liang Dong, Zhengwei Xu, Xiujin Chen, Dongqi Wang, Dichen Li, Tuanjing Liu, Dingjun Hao
BACKGROUD CONTEXT: Many meta-analyses have been performed to study the efficacy of cervical disc arthroplasty (CDA) compared with anterior cervical discectomy and fusion (ACDF); however, there are few data referring to adjacent segment within these meta-analyses, or investigators are unable to arrive at the same conclusion in the few meta-analyses about adjacent segment. With the increased concerns surrounding adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis) after anterior cervical surgery, it is necessary to perform a comprehensive meta-analysis to analyze adjacent segment parameters...
June 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28622909/biomechanical-evaluation-of-a-novel-pedicle-screw-based-interspinous-spacer-a-finite-element-analysis
#7
Hsin-Chang Chen, Jia-Lin Wu, Shou-Chieh Huang, Zheng-Cheng Zhong, Shiu-Ling Chiu, Yu-Shu Lai, Cheng-Kung Cheng
Interspinous spacers have been designed to provide a minimally invasive surgical technique for patients with lumbar spinal stenosis or foraminal stenosis. A novel pedicle screw-based interspinous spacer has been developed in this study, and the aim of this finite element experiment was to investigate the biomechanical differences between the pedicle screw-based interspinous spacer (M-rod system) and the typical interspinous spacer (Coflex-F™). A validated finite element model of an intact lumbar spine was used to analyze the insertions of the Coflex-F™, titanium alloy M-rod (M-Ti), and polyetheretherketone M-rod (M-PEEK), independently...
June 13, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28622185/a-comprehensive-meta-analysis-of-the-adjacent-segment-parameters-in-cervical-disk-arthroplasty-versus-anterior-cervical-discectomy-and-fusion
#8
Liang Dong, Dongqi Wang, Xiujin Chen, Tuanjing Liu, Zhengwei Xu, Mingsheng Tan, Dingjun Hao
STUDY DESIGN: This is a meta-analysis of controlled trials. OBJECTIVE: To assess the overall condition of adjacent segment of cervical disk arthroplasty (CDA) compared with anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: With the increase in CDA and ACDF, surgeons are taking more attention to adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis). There are more and more meta-analyses comparing the efficacy of CDA with ACDF, however, there are few meta-analyses referring to adjacent segment parameters, and investigators are still unable to arrive at the same conclusion...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28620752/fatty-metaplasia-quantification-and-impact-on-regional-myocardial-function-as-assessed-by-advanced-cardiac-mr-imaging
#9
Tomas Lapinskas, Bernhard Schnackenburg, Marc Kouwenhoven, Rolf Gebker, Alexander Berger, Remigijus Zaliunas, Burkert Pieske, Sebastian Kelle
OBJECTIVE: This study aimed to investigate the advantages of recently developed cardiac imaging techniques of fat-water separation and feature tracking to characterize better individuals with chronic myocardial infarction (MI). MATERIALS AND METHODS: Twenty patients who had a previous MI underwent CMR imaging. The study protocol included routine cine and late gadolinium enhancement (LGE) technique. In addition, mDixon LGE imaging was performed in every patient. Left ventricular (LV) circumferential (EccLV) and radial (ErrLV) strain were calculated using dedicated software (CMR(42), Circle, Calgary, Canada)...
June 15, 2017: Magma
https://www.readbyqxmd.com/read/28618336/left-ventricle-hermite-based-segmentation
#10
Jimena Olveres, Rodrigo Nava, Boris Escalante-Ramírez, Enrique Vallejo, Jan Kybic
In recent years, computed tomography (CT) has become a standard technique in cardiac imaging because it provides detailed information that may facilitate the diagnosis of the conditions that interfere with correct heart function. However, CT-based cardiac diagnosis requires manual segmentation of heart cavities, which is a difficult and time-consuming task. Thus, in this paper, we propose a novel technique to segment endocardium and epicardium boundaries based on a 2D approach. The proposal computes relevant information of the left ventricle and its adjacent structures using the Hermite transform...
May 31, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28614279/reoperation-rates-following-instrumented-lumbar-spine-fusion
#11
Tero Matti Irmola, Arja Häkkinen, Salme Järvenpää, Ilkka Marttinen, Kimmo Vihtonen, Marko Neva
STUDY DESIGN: OBJECTIVE.: This study evaluated the cumulativereoperation rate and indications for reoperation following instrumented lumbar spine fusion (LSF). SUMMARY OF BACKGROUND DATA: LSF reduces disability and improves health-related quality of life for patients with several spinal disorders. The rate of instrumented LSF has drastically increased over the last few decades.The increased incidence of LSF, however, has led to increased reoperation rates. METHODS: The data are based on the prospective LSF database of Tampere University Hospital that includes all elective indications for LSF surgery...
June 13, 2017: Spine
https://www.readbyqxmd.com/read/28611586/the-distribution-of-charged-amino-acid-residues-and-the-ca-2-permeability-of-nicotinic-acetylcholine-receptors-a-predictive-model
#12
Sergio Fucile
Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca(2+) permeability depending on their subunit composition. The Ca(2+) permeability is a crucial functional parameter to understand the physiological role of nAChRs, in particular considering their ability to modulate Ca(2+)-dependent processes such as neurotransmitter release. The rings of extracellular and intracellular charged amino acid residues adjacent to the pore-lining TM2 transmembrane segment have been shown to play a key role in the cation selectivity of these receptor channels, but to date a quantitative relationship between these structural determinants and the Ca(2+) permeability of nAChRs is lacking...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28610920/photoinactivation-related-dynamics-of-ctenophore-photoproteins-insights-from-molecular-dynamics-simulation-under-electric-field
#13
Zaiddodine Pashandi, Maryam Molakarimi, Ammar Mohseni, Reza H Sajedi, Majid Taghdir, Hossein Naderi-Manesh
Photoinactivation is a common phenomenon in bioluminescence ctenophore photoproteins (e.g mnemiopsin, berovin and BfosPP) with still unknown mechanism. The activity of coelenterate photoproteins (e.g aequorin), which has high structural similarity with ctenophore photoproteins, is not affected by light. Recently, we have characterized the effects of light on ctenophore photoprotein mnemiopsin, in different conformations, which has demonstrated light induced structural changes, uniquely secondary structures, of both apo and holo mnemiopsin...
June 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28607336/cervical-spine-motion-during-tracheal-intubation-with-king-visiontm-video-laryngoscopy-and-conventional-laryngoscopy-a-crossover-randomized-study
#14
Mohamed R El-Tahan, Samah El Kenany, Alaa M Khidr, Abdulmohsen A Al Ghamdi, Ahmed M Tawfik, Abdullah S Al Mulhim
BACKGROUND: The King VisonTM (KVL) videolaryngoscope with a wide field of view could potentially reduce cervical spine motion during intubation. We aimed to compare the extent of cervical spine movement during laryngoscopy using the KVL and Macintosh laryngoscopes. METHODS: Following ethical approval, 29 patients with a normal cervical spine requiring general anesthesia and tracheal intubation were randomly subjected to both KVL and Macintosh laryngoscopy in a crossover...
June 12, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28606581/the-effect-of-single-level-disc-degeneration-on-dynamic-response-of-the-whole-lumbar-spine-to-vertical-vibration
#15
Li-Xin Guo, Wei Fan
OBJECTIVE: The objective of this study was to investigate the effect of single-level disc degeneration on dynamic response of the whole lumbar spine to vertical whole body vibration that is typically present when driving vehicles. METHODS: Ligamentous finite element models of the lumbar L1-S1 motion segment in different grades of degeneration (healthy, mild and moderate) at L4-L5 level were developed with consideration of changing disc height and material properties of the nucleus pulpous...
June 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28604553/flow-through-free-fibula-osteocutaneous-flap-in-reconstruction-of-tibial-bone-soft-tissue-and-main-artery-segmental-defects
#16
Zonghuan Li, Aixi Yu, Baiwen Qi, Zhenyu Pan, Junhui Ding
OBJECTIVE: The aim of this report was to present the use of flow-through free fibula osteocutaneous flap for the repair of complex tibial bone, soft tissue, and main artery segmental defects. PATIENTS AND METHODS: Five patients with bone, soft tissue, and segmental anterior tibial artery defects were included. The lengths of injured tibial bones ranged from 4 to 7 cm. The sizes of impaired soft tissues were between 9 × 4 and 15 × 6 cm. The lengths of defect of anterior tibial artery segments ranged from 6 to 10 cm...
June 9, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28604508/symptomatic-adjacent-segment-disease-after-anterior-cervical-discectomy-for-single-level-degenerative-disk-disease
#17
Roland D Donk, Wim I M Verhagen, Allard J F Hosman, Andre Verbeek, Ronald H M A Bartels
STUDY DESIGN: A prospective cohort of 142 patients underwent either anterior cervical discectomy alone, anterior cervical discectomy with fusion by cage stand-alone, or anterior cervical discectomy with arthroplasty. We then followed up on their condition for a mean of 9.1±1.9 years (5.6-12.2 y) later. OBJECTIVE: We aimed to evaluate the annual rate of clinically symptomatic adjacent segment disease (ASD) and to analyze predictive factors. SUMMARY OF BACKGROUND DATA: Until recent, ASD has been predominantly evaluated radiologically...
June 9, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#18
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28602928/which-approach-is-advantageous-to-preventing-the-development-of-asd-a-comparative-analysis-of-3-different-lumbar-interbody-fusion-techniques-alif-llif-and-plif-in-l4-5-spondylolisthesis
#19
Chul-Woo Lee, Kang-Jun Yoon, Sang-Soo Ha
OBJECTIVE: The purpose of this study was to compare radiological and clinical outcomes in patients with L4-5 lumbar spondylolisthesis who have undergone either instrumented Anterior lumbar interbody fusion (ALIF), Lateral lumbar interbody fusion (LLIF), or Posterior Lumbar interbody fusion (PLIF), especially with regard to the development of Adjacent segment disease (ASD). METHODS: Eighty-two patients with preoperative L4-5 spondylolisthesis and minimal ASD who underwent instrumented L4-5 fusion were divided into three groups according to the surgical approach used for treatment (ALIF: 27 patients, LLIF: 24 patients, PLIF: 31 patients)...
June 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28601432/stability-and-surgical-complications-in-segmental-le-fort-i-osteotomy-a-systematic-review
#20
REVIEW
O L Haas Junior, R Guijarro-Martínez, A P de Sousa Gil, L da Silva Meirelles, R B de Oliveira, F Hernández-Alfaro
This systematic review was conducted to evaluate the stability and surgical complications of segmental Le Fort I osteotomy. The search was divided into a main search (PubMed, Embase, and Cochrane Library), grey literature search (Google Scholar), and manual search. Twenty-three studies were included: 14 evaluating stability as the outcome and nine evaluating surgical complications. The level of agreement between the authors was considered excellent (κ=0.893 for study selection and κ=0.853 for study eligibility)...
June 7, 2017: International Journal of Oral and Maxillofacial Surgery
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