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Adjacent Segment

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https://www.readbyqxmd.com/read/29341730/polymer-chain-conformation-and-dynamical-confinement-in-a-model-one-component-nanocomposite
#1
C Mark, O Holderer, J Allgaier, E Hübner, W Pyckhout-Hintzen, M Zamponi, A Radulescu, A Feoktystov, M Monkenbusch, N Jalarvo, D Richter
We report a neutron-scattering investigation on the structure and dynamics of a single-component nanocomposite based on SiO_{2} particles that were grafted with polyisoprene chains at the entanglement limit. By skillful labeling, we access both the monomer density in the corona as well as the conformation of the grafted chains. While the corona profile follows a r^{-1} power law, the conformation of a grafted chain is identical to that of a chain in a reference melt, implying a high mutual penetration of the coronas from different particles...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29339678/endarteritis-of-coarctation-of-the-aorta-diagnosed-with-pet-ct
#2
Ümit Yaşar Sinan, Burcu Dirlik Serim, Rukiye Yıldırım, Özge Çetinarslan, Mehmet Serdar Küçükoğlu
Infective endocarditis (IE) is an infectious disease that affects the endothelium of the large intrathoracic vessels, heart valves, and intra-cardiac foreign body material. A 20-year-old woman was admitted to the cardiology department with complaints of fever and palpitations. Transthoracic echocardiography revealed a bicuspid aortic valve, aortic root enlargement, and aortic coarctation. Transesophageal echocardiography revealed a bicuspid aortic valve, but there was no vegetation. Methicillin-sensitive Staphylococcus aureus was identified on a blood culture...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29339480/local-policy-proposals-can-bridge-latino-and-most-white-americans-response-to-immigration
#3
Yuen J Huo, John F Dovidio, Tomás R Jiménez, Deborah J Schildkraut
In the past 15 years, the adoption of subnational immigration policies in the United States, such as those established by individual states, has gone from nearly zero to over 300 per year. These include welcoming policies aimed at attracting and incorporating immigrants, as well as unwelcoming policies directed at denying immigrants access to public resources and services. Using data from a 2016 random digit-dialing telephone survey with an embedded experiment, we examine whether institutional support for policies that are either welcoming or hostile toward immigrants differentially shape Latinos' and whites' feelings of belonging in their state (Arizona/New Mexico, adjacent states with contrasting immigration policies)...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29335761/adjacent-intervertebral-space-infection-after-lumbar-fusion
#4
Hong-Kui Xin, Qing He
BACKGROUND: Surgical site infection is a catastrophic complication after spinal surgery, which seriously affects the progress of rehabilitation and clinical outcome. Currently the clinical reports on spinal surgical site infections are mostly confined to the surgical segment itself and there are few reports on adjacent segment infections after spinal surgery. STUDY DESIGN: Case report. OBJECTIVE: To report a clinical case with adjacent level infection after spinal fusion...
January 15, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29332307/scaffold-thrombosis-following-implantation-of-the-absorb-bvs-in-routine-clinical-practice-insight-into-possible-mechanisms-from-optical-coherence-tomography
#5
Robin P Kraak, Alexandre H Kajita, Hector M Garcia-Garcia, Jose P S Henriques, Jan J Piek, E Karin Arkenbout, René J van der Schaaf, Jan G P Tijssen, Robbert J de Winter, Joanna J Wykrzykowska
OBJECTIVES: To identify potential underlying mechanisms of early and (very) late scaffold thrombosis (ScT) by optical coherence tomography (OCT), in a frame-by-frame analysis. BACKGROUND: The absorb scaffold is associated with an increased risk of ScT compared with metallic stents. Several potential causes of bioresorbable ScT have been identified, however the precise etiology still remains unclear. METHODS: Between February 2013 and February 2016, 13 patients presenting with definite ScT underwent OCT imaging...
January 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29330341/biomechanics-of-coupled-motion-in-the-cervical-spine-during-simulated-whiplash-in-patients-with-pre-existing-cervical-or-lumbar-spinal-fusion-a-finite-element-study
#6
H Huang, R W Nightingale, A B C Dang
OBJECTIVES: Loss of motion following spine segment fusion results in increased strain in the adjacent motion segments. However, to date, studies on the biomechanics of the cervical spine have not assessed the role of coupled motions in the lumbar spine. Accordingly, we investigated the biomechanics of the cervical spine following cervical fusion and lumbar fusion during simulated whiplash using a whole-human finite element (FE) model to simulate coupled motions of the spine. METHODS: A previously validated FE model of the human body in the driver-occupant position was used to investigate cervical hyperextension injury...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29329312/a-computational-study-of-the-impact-of-inhomogeneous-internodal-lengths-on-conduction-velocity-in-myelinated-neurons
#7
Abby Scurfield, David C Latimer
Age-related decreases in the conduction velocity (CV) of action potentials along myelinated axons have been linked to morphological changes in the myelin sheath. In particular, evidence suggests the presence of segmental demyelination and remyelination of axons. In remyelinated segments, the distance between adjacent nodes of Ranvier is typically shorter, and myelin sheaths are thinner. Both experimental and computational evidence indicates that shortened internodes slows CV. In this computational study, we determine the impact of progressive segmental demyelination and remyelination, modeled by shorter internodes with thinner myelin sheaths interspersed with normal ones, upon the CV...
2018: PloS One
https://www.readbyqxmd.com/read/29325333/-biomechanical-effects-on-adjacent-segments-of-different-growing-rod-fixation-in-early-onset-scoliosis
#8
Y Hai, A X Pan, Y G Li, L Zang, S Yuan
Objective: To analyse the biomechanical effects on adjacent segments of different growing-rod (GR) fixation in early onset scoliosis through a finite element analysis method. Methods: A severe early-onset scoliosis patient was selected and the pre-operation and post-GR-operation (Upper instrumented levels: T(4), T(5). Lower instrumented levels: L(3), L(4)) whole spine 3-dimentional CT scan data were collected to build the finite models. Based on the different models, biomechanical differences on adjacent segments were analysed...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29325074/cervical-disc-arthroplasty-current-evidence-and-real-world-application
#9
Pierce D Nunley, Domagoj Coric, Kelly A Frank, Marcus B Stone
Cervical total disc replacement (cTDR) is still considered a developing technology, with widespread clinical use beginning in the early 2000s. Despite being relatively new to the marketplace, the literature surrounding cTDR is abundant. We conducted a thorough review of literature published in the United States (US) and outside the US to report the current global state of cTDR research and clinical use. Search criteria were restricted to publications with a clinical patient population, excluding finite element analyses, biomechanical studies, cadaver studies, surgical technique-specific papers, and case studies...
January 6, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29322911/comparison-of-lumbar-pedicular-dynamic-stabilisation-systems-versus-fusion-for-the-treatment-of-lumbar-degenerative-disc-disease-a-meta-analysis
#10
Y-J Huang, S-J Zhao, Q Zhang, L-M Nong, N-W Xu
This study aimed to systematically compare the safety, effectiveness and radiological changes after lumbar pedicular dynamic stabilisation systems and fusion to treat lumbar degenerative disc disease . All studies that were performed to compare various lumbar pedicular dynamic stabilisation systems with any lumbar fusion to treat lumbar degenerative disc disease and were published until April 30, 2015 were acquired through a comprehensive search in various databases. A meta-analysis was performed after the methodological qualities of trials were assessed and after data were extracted...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29319182/long-noncoding-rna-casc2-regulates-hepatocellular-carcinoma-cell-oncogenesis-through-mir-362-5p-nf-%C3%AE%C2%BAb-axis
#11
Liang Zhao, Yongjian Zhang, Yubao Zhang
The long non-coding RNA segment cancer susceptibility candidate 2 (CASC2) has been shown to suppress tumor growth in a variety of cancers, including hepatocellular carcinoma (HCC). However, the mechanism by which CASC2 exerts control over HCC has yet to be established. In the present study, we first demonstrated that CASC2 is downregulated in human HCC tissues and HCC cell lines as compared to adjacent non-tumor tissues and a liver cell line, respectively. After finding that CASC2 knockdown significantly promotes HCC cells migration and invasion as well as that CASC2 overexpression inhibits cell migration and invasion, we identified the microRNA miR-362-5p as an endogenous target of CASC2...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29317980/a-history-of-kawasaki-disease-from-childhood-and-coronary-artery-ectasia-with-recurrent-st-elevation-myocardial-infarction-a-therapeutic-challenge
#12
Ashraf Abugroun, Daniel Vilchez, Osama Hallak, Anahita Shahrrava
Coronary artery ectasia (CAE) is an uncommon anomaly, usually found in 1.2-2% of patients undergoing coronary angiography, defined as a segment of the coronary artery that has a diameter of more than 1.5 times the normal adjacent segments. Atherosclerosis is considered as the cause of half of the CAE cases. We herein present a 65-year-old Asian male with past medical history of Kawasaki disease (KD) who developed recurrent episodes of inferior wall ST-elevation myocardial infarction (STEMI) despite treatment with dual antiplatelet therapy (DAPT)...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29317970/evaluation-of-the-tp-te-interval-qtc-and-p-wave-dispersion-in-patients-with-coronary-artery-ectasia
#13
Ronan Conlon, Richard Tanner, Santhosh David, Gabor Szeplaki, Joseph Galvin, John Keaney, Edward Keelan, Usama Boles
Background: Coronary artery ectasia (CAE) is defined as a diffuse dilatation of the diameter of the ectatic segment of the coronary artery, 1.5 times greater than that of the adjacent segment. The Tp-Te interval, P-wave and QTc dispersions are relatively new electrocardiographic markers associated with an increased risk of developing arrhythmias. Despite CAE increasing in prevalence in recent years, there is a sparsity of data available about its arrhythmogenic effect. The aim of the study was to evaluate QTc, P-wave dispersion and Tp-Te and Tp-Te/QT ratio in patients with CAE...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29316936/perioperative-complications-after-surgical-treatment-in-degenerative-adult-de-novo-scoliosis
#14
Maciej J K Simon, Henry F H Halm, Markus Quante
BACKGROUND: Degenerative adult de novo (DAD) scoliosis appears characteristically in the sixth or seventh decade with symptoms of severe back pain and radiculopathy or spinal claudication. The aim of this study was to enhance the knowledge of perioperative complications and detect possible risk factors in this selective DAD scoliosis surgery. METHODS: This retrospective study included only patients with DAD scoliosis undergone correction spondylodesis with previous failure of conservative treatment...
January 10, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29315121/cervical-total-disk-arthroplasty
#15
Timothy T Roberts, Ryan J Filler, Jason W Savage, Edward C Benzel
In the United States, cervical total disk arthroplasty (TDA) is US Federal Drug Administration (FDA) approved for use in both 1 and 2-level constructions for cervical disk disease resulting in myelopathy and/or radiculopathy. TDA designs vary in form, function, material composition, and even performance in vivo. However, the therapeutic goals are the same: to remove the painful degenerative/damaged elements of the intervertebral discoligamenous joint complex, to preserve or restore the natural range of spinal motion, and to mitigate stresses on adjacent spinal segments, thereby theoretically limiting adjacent segment disease (ASDis)...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29315118/characteristics-of-cervical-spine-motion-in-different-types-of-cervical-alignment-kinematic-mri-study
#16
Kittipong Sessumpun, Permsak Paholpak, Kevork N Hindoyan, Koji Tamai, Thananit Sangkomkamhang, Zorica Buser, Jeffrey C Wang
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate how each type of sagittal cervical alignment affects the motion of the upper and subaxial cervical spine using kinematic magnetic resonance imaging. SUMMARY OF BACKGROUND DATA: The sagittal malalignment of the cervical spine from degeneration in the subaxial cervical spine reflects a disruption in the kinematic properties of the cervical spine and affects the motion of adjacent segments...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29313113/epidemiology-and-contemporary-management-of-abdominal-aortic-aneurysms
#17
Brant W Ullery, Richard L Hallett, Dominik Fleischmann
Abdominal aortic aneurysm (AAA) is most commonly defined as a maximal diameter of the abdominal aorta in excess of 3 cm in either anterior-posterior or transverse planes or, alternatively, as a focal dilation ≥ 1.5 times the diameter of the normal adjacent arterial segment. Risk factors for the development of AAA include age > 60, tobacco use, male gender, Caucasian race, and family history of AAA. Aneurysm growth and rupture risk appear to be associated with persistent tobacco use, female gender, and chronic pulmonary disease...
January 9, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29307048/biomechanical-analysis-of-a-new-lumbar-interspinous-device-with-optimized-topology
#18
Chen-Sheng Chen, Shih-Liang Shih
Interspinous spacers used stand-alone preserve joint movement but provide little protection for diseased segments of the spine. Used as adjuncts with fusion, interspinous spacers offer rigid stability but may accelerate degeneration on adjacent levels. Our new device is intended to balance the stability and preserves motion provided by the implant. A new interspinous spacer was devised according to the results of topology optimization studies. Four finite element (FE) spine models were created that consisted of an intact spine without an implant, implantation of the novel, the device for intervertebral assisted motion (DIAM system), and the Dynesys system...
January 6, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29301049/treatment-of-an-anterior-inferior-cerebellar-artery-aneurysm-with-microsurgical-trapping-and-in-situ-posterior-inferior-cerebellar-artery-to-anterior-inferior-cerebellar-artery-bypass-case-report
#19
Bryan S Lee, Alex M Witek, Nina Z Moore, Mark D Bain
BACKGROUND: Anterior inferior cerebellar artery (AICA) aneurysms are rare lesions whose treatment can involve microsurgical and/or endovascular techniques. Such treatment can be challenging and may carry a significant risk of neurological morbidity. OBJECTIVE: To demonstrate a case involving a complex AICA aneurysm that was treated with a unique microsurgical approach involving trapping the aneurysm and performing in Situ bypass from the posterior inferior cerebellar artery (PICA) to the distal AICA...
December 30, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29288770/the-3-end-region-of-the-human-pdgfr-%C3%AE-core-promoter-nuclease-hypersensitive-element-forms-a-mixture-of-two-unique-end-insertion-g-quadruplexes
#20
Buket Onel, Megan Carver, Prashansa Agrawal, Laurence H Hurley, Danzhou Yang
BACKGROUND: While the most stable G-quadruplex formed in the human PDGFR-β promoter nuclease hypersensitive element (NHE) is the 5'-mid G-quadruplex, the 3'-end sequence that contains a 3'-GGA run forms a less stable G-quadruplex. Recently, the 3'-end G-quadruplex was found to be a transcriptional repressor and can be selectively targeted by a small molecule for PDGFR-β downregulation. METHOD: We use 1D and 2D high-field NMR, in combination with Dimethylsulfate Footprinting, Circular Dichroism Spectroscopy, and Electrophoretic Mobility Shift Assay...
December 27, 2017: Biochimica et Biophysica Acta
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