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Osteoporosis calcium

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https://www.readbyqxmd.com/read/28816876/osteoporotic-thoracolumbar-fractures-how-are-they-different-classification-and-treatment-algorithm
#1
Shanmuganathan Rajasekaran, Rishi M Kanna, Klaus J Schnake, Alexander R Vaccaro, Gregory D Schroeder, Said Sadiqi, Cumhur Oner
Osteoporotic vertebral fractures constitute at least 50% of the osteoporotic fractures that happen worldwide. Occurrence of osteoporotic fractures make the elderly patient susceptible for further fractures and increases the morbidity due to kyphosis and pain; the mortality risk is also increased in these patients. Most fractures occur in the thoracic and thoracolumbar region and are often stable. Different descriptive and prognostic classification systems have been described, but none are universally accepted...
September 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28815389/spine-bone-mineral-density-increases-after-6%C3%A2-months-of-exclusive-lactation-even-in-women-who-keep-breastfeeding
#2
Sandra Cooke-Hubley, Beth J Kirby, James E Valcour, Gerald Mugford, Jonathan D Adachi, Christopher S Kovacs
This pilot study enrolled 31 women who had breastfed exclusively for 6 months. Lumbar and thoracic BMD increased 4 and 5%, respectively. Femoral neck and total body BMD did not change. Return of menses and progestin-only pill use were two potential signals that predicted a greater increase in BMD. PURPOSE/INTRODUCTION: The skeleton is resorbed during lactation to provide much of the calcium content of milk. After lactation ceases, these deficits in skeletal mineral content are largely restored, such that lactation has a neutral or protective effect against the long-term risk of low bone mineral density (BMD), osteoporosis, and fragility fractures...
August 16, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28812252/secondary-fracture-prevention-in-hip-fracture-patients-requires-cooperation-from-general-practitioners
#3
Jan Vaculík, Jan J Stepan, Pavel Dungl, Marek Majerníček, Alexander Čelko, Valér Džupa
Despite individual recommendations on osteoporosis management in patients after hip fracture surgery, addressed by orthopedic surgeons to Czech general practitioners, the patients remained undiagnosed and untreated because of provider-level barriers to post-fracture secondary prevention. PURPOSE: The goal of the study was to assess whether an individual recommendation on osteoporosis treatment addressed to a hip fracture patient's GP would lead to better osteoporosis management. METHODS: Two groups of patients who suffered hip fractures and were treated at the Orthopedic Department were evaluated...
May 18, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28810524/pioglitazone-induced-bone-loss-in-diabetic-rats-and-its-amelioration-by-berberine-a-portrait-of-molecular-crosstalk
#4
Mohammad Adil, Mohd Nizam Mansoori, Divya Singh, Amit Dattatraya Kandhare, Manju Sharma
Diabetes mellitus and osteoporosis both are high prevalence disorders, especially in the elderly population. Pioglitazone, a PPAR-γ agonist associated with bone loss and risk of fracture in type 2 diabetes mellitus patients. In this study, ameliorative effect of berberine against pioglitazone-induced bone loss in diabetic rats and possible mechanisms has been explored. Diabetes was induced in male Wistar albino rats by streptozotocin (65 mg/kg, i.v.) after 15min of nicotinamide (230mg/kg, i.p.) administration...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28806302/surgery-for-primary-hyperparathyroidism-adherence-to-consensus-guidelines-in-an-academic-health-system
#5
Eric J Kuo, Mostafa A Al-Alusi, Lin Du, Albert Shieh, Masha J Livhits, Angela M Leung, Michael W Yeh
OBJECTIVE: To determine the extent to which consensus guidelines for surgery in patients with primary hyperparathyroidism (PHPT) are followed within an academic health system. BACKGROUND: Previous studies have shown that adherence to consensus guidelines in community practice is low. METHODS: Adults with biochemically confirmed PHPT who received primary care within an academic health system were identified from 2005 to 2015. Multivariable logistic regression was used to analyze predictors of parathyroidectomy (PTx)...
August 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28804568/preventive-effects-of-kudzu-root-on-bone-loss-and-cartilage-degradation-in-ovariectomized-rat
#6
Yunyun Luo, Shuang Zheng, Yujia Ding, Yueqin Dai, Yi Zhou, Ruifeng Xiang, Anne C Bay-Jensen, Morten A Karsdal, Per Qvist, Qinlong Zheng
The clinical utility of Traditional Chinese Medicine (TCM) herbs/roots extracts in osteoporosis (OP) and osteoarthritis (OA) has been described in multiple reports, but there have been few studies of TCM for preventing bone loss and cartilage degradation simultaneously. Six-month-old female Sprague-Dawley rats each were subjected to ovariectomized (OVX) or sham surgery and treated orally once daily with herbal extracts or vehicle. Body weight was recorded weekly, and blood samples were collected from fasting animals at different time points...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28798761/harnessing-finger-millet-to-combat-calcium-deficiency-in-humans-challenges-and-prospects
#7
REVIEW
Swati Puranik, Jason Kam, Pranav P Sahu, Rama Yadav, Rakesh K Srivastava, Henry Ojulong, Rattan Yadav
Humans require more than 20 mineral elements for healthy body function. Calcium (Ca), one of the essential macromineral, is required in relatively large quantities in the diet for maintaining a sound overall health. Young children, pregnant and nursing women in marginalized and poorest regions of the world, are at highest risk of Ca malnutrition. Elderly population is another group of people most commonly affected by Ca deficiency mainly in the form of osteoporosis and osteopenia. Improved dietary intake of Ca may be the most cost-effective way to meet such deficiencies...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28797304/prevalence-of-vitamin-d-supplement-use-in-australian-residential-aged-care-facilities-in-november-2014
#8
Pippy Walker, Amanda Miller Amberber, Susan Kurrle, Annette Kifley, Ian D Cameron
OBJECTIVE: We sought to establish the prevalence and predictors of adequate vitamin D supplement use, as per current falls prevention guidelines in Australian aged care homes. De-identified medication chart data from November 2014 were collected from pharmacists. The proportion of residents prescribed vitamin D and associations between adequate vitamin D supplementation and state, calcium use and osteoporosis medication use were assessed. RESULTS: The prevalence of adequate vitamin D supplement use (≥800 IU) was 47...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28794160/primary-aldosteronism-as-a-cause-of-secondary-osteoporosis
#9
Antonio Stefano Salcuni, Vincenzo Carnevale, Claudia Battista, Serena Palmieri, Cristina Eller-Vainicher, Vito Guarnieri, Flavia Pugliese, Giuseppe Guglielmi, Gaetano Desina, Salvatore Minisola, Iacopo Chiodini, Alfredo Scillitani
OBJECTIVE: Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. DESIGN: Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. METHODS: A total of 2632 patients were evaluated. 2310 were excluded because they were taking drugs known to affect bone or mineralocorticoids metabolism, or were diagnosed to have a secondary cause of osteoporosis...
August 8, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28790475/transient-osteoporosis-of-the-hip-a-mysterious-cause-of-hip-pain-in-adults
#10
Raju Vaishya, Amit Kumar Agarwal, Virender Kumar, Vipul Vijay, Abhishek Vaish
BACKGROUND: Transient osteoporosis of the hip (TOH) is a poorly understood and forgotten clinical entity. The diagnosis is often delayed, and inappropriate treatment is provided, due to the lack of its awareness among the clinicians. MATERIALS AND METHODS: Twelve patients (11 male and one female) within the age group of 35-50 years, were identified retrospectively from the hospital records between July 2011 and June 2015 who had evidence of TOH on clinical and radiological parameters...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28778053/release-behavior-and-signaling-effect-of-vitamin-d3-in-layered-double-hydroxides-hydroxyapatite-gelatin-bone-tissue-engineering-scaffold-an-in-vitro-evaluation
#11
Fateme Fayyazbakhsh, Mehran Solati-Hashjin, Abbas Keshtkar, Mohammad Ali Shokrgozar, Mohammad Mehdi Dehghan, Bagher Larijani
Incorporating the controlled release of vitamin D3 (VD3) into biodegradable porous scaffolds is a new approach to equipping multifunctional therapeutics for osteoporosis. The current investigation involves the encapsulation of VD3 into gelatin through the one-step desolvation method. The layered double hydroxides-hydroxyapatite nanocomposite (LDH-HAp) and pure LDH were combined with the gelatin-VD3 complex to reinforce the porous biodegradable structure and enhance the biological response. Afterwards, glutaraldehyde was used to form crosslinks within the gelatin chains...
July 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28775273/calcium-and-vitamin-d-deficiency-marginally-impairs-fracture-healing-but-aggravates-posttraumatic-bone-loss-in-osteoporotic-mice
#12
Verena Fischer, Melanie Haffner-Luntzer, Katja Prystaz, Annika Vom Scheidt, Björn Busse, Thorsten Schinke, Michael Amling, Anita Ignatius
Calcium and vitamin-D (Ca/VitD) deficiency is a major risk factor for osteoporosis. It may also contribute to the compromised bone healing frequently observed in osteoporotic patients, since calcium is essential for fracture-callus mineralization. Additionally, clinical data suggest systemic bone loss following fracture, which may aggravate osteoporosis and thus increase the risk for fragility fractures in osteoporotic patients further. However, the role of Ca/VitD in fracture healing and posttraumatic bone turnover has to date been poorly investigated...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28771973/trends-and-determinants-of-osteoporosis-treatment-and-screening-in-patients-with-rheumatoid-arthritis-compared-to-osteoarthritis
#13
Gulsen Ozen, Diane L Kamen, Ted R Mikuls, Bryant R England, Frederick Wolfe, Kaleb Michaud
OBJECTIVE: To profile osteoporosis (OP) care in patients with rheumatoid arthritis (RA) over the past decade. METHODS: Patients with RA or osteoarthritis (OA) were followed from 2003 through 2014. OP care was defined as receipt of OP treatment (with exception of calcium/vitamin D) or screening (OPTS). Adjusted trends over follow-up, and the factors associated with OP care were examined using the multivariable Cox proportional hazards. RESULTS: OPTS was reported in 67...
August 3, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28771720/cyanidin-chloride-inhibits-ovariectomy-induced-osteoporosis-by-suppressing-rankl-mediated-osteoclastogenesis-and-associated-signaling-pathways
#14
Jianwen Cheng, Lin Zhou, Qian Liu, Jennifer Tickner, Zhen Tan, Xiaofeng Li, Mei Liu, Xixi Lin, Tao Wang, Nathan J Pavlos, Jinmin Zhao, Jiake Xu
Over-production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor-associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties, but its role in osteoclastic bone resorption and osteoporosis is not well understood. In this study, we showed that Cyanidin Chloride inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression; including ctr, ctsk and trap...
August 3, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28768651/combined-bioavailable-isoflavones-and-probiotics-improve-bone-status-and-estrogen-metabolism-in-postmenopausal-osteopenic-women-a-randomized-controlled-trial
#15
Max Norman Tandrup Lambert, Catrine Bundgaard Thybo, Simon Lykkeboe, Lars Melholt Rasmussen, Xavier Frette, Lars Porskjær Christensen, Per Bendix Jeppesen
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therapy is demonstrated to increase cancer risk. Bioavailable isoflavones with selective estrogen receptor affinity show potential to prevent and treat osteoporosis while minimizing or eliminating carcinogenic side effects.Objective: In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia...
August 2, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28767464/role-of-osteogenic-coatings-on-implant-surfaces-in-promoting-bone-to-implant-contact-in-experimental-osteoporosis-a-systematic-review-and-meta-analysis
#16
Alexis Ghanem, Sergio Varela Kellesarian, Tariq Abduljabbar, Nawwaf Al-Hamoudi, Fahim Vohra, Fawad Javed
OBJECTIVE: The aim of this systematic review and meta-analysis was to evaluate the role of osteogenic coatings (placement of a thin film of organic and inorganic osteoinductive and osteoproliferative materials) on implant surfaces in augmenting bone-to-implant contact (BIC) in osteoporotic bone. DATA SOURCES: To answer the focused question "Do osteogenic coatings on implant surfaces increase BIC in osteoporotic bone?" PubMed/MEDLINE, EMBASE, ISI Web of Knowledge, Scopus, and Google-Scholar databases were searched till June 2017 using different combinations of the following key words: bone-to-implant contact, coating, implant surface, osseointegration, and osteoporosis...
July 31, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28748897/milk-alkali-syndrome-induced-by-h1n1-influenza-vaccine
#17
Abdullah K Al-Hwiesh, Ibrahiem Saeed Abdul-Rahman, Nadia Al-Oudah, Sana Al-Solami, Fahd A Al-Muhanna
Milk-Alkali syndrome (MAS) consists of a triad of hypercalcemia, metabolic alkalosis, and acute renal failure. We hereby report a 75-year-old Indian gentleman who presented to our emergency department with a history of generalized weakness and easy fatigability. Investigations were consistent with MAS secondary to calcium carbonate and calcitriol treatment to prevent osteoporosis, aggravated by H1N1 influenza vaccine. The patient was treated with hemodialysis and zoledronate. To our knowledge, this is the first reported case of such association in the literature...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748173/stereological-investigation-of-the-effect-of-elaeagnus-angustifolia-fruit-hydroalcoholic-extract-on-osteoporosis-in-ovariectomized-rats
#18
Mohmmad Hossein Dabbaghmanesh, Ali Noorafshan, Pedram Talezadeh, Nader Tanideh, Farhad Koohpeyma, Aida Iraji, Marzieh Bakhshayeshkaram, Nima Montazeri-Najafabady
OBJECTIVE: Postmenopausal osteoporosis is characterized by increased fracture risk. However, each approved treatment has specific side effects. Therefore, foods with plant origins have increasingly attracted attention as an alternative treatment. Studies have shown that Elaeagnus angustifolia (EA) has antioxidant properties. The present study aimed to investigate the effects of EA hydroalcoholic extract on ovariectomy-induced osteoporosis in rats using stereological methods. MATERIAL AND METHODS: 55 female Sprague-Dawley rats were randomly assigned to control, sham operated (normal saline), ovariectomized (OVX), OVX + EA fruit extract (600 mg/kg BW/day), and OVX + estradiol benzoate (3 mg/kg BW) for 16 weeks...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28746019/evaluation-of-a-just-in-time-nurse-consultation-on-bone-health-a-pilot-randomized-controlled-trial
#19
Douglas W Roblin, David Zelman, Sally Plummer, Brandi E Robinson, Yiyue Lou, Stephanie W Edmonds, Fredric D Wolinsky, Kenneth G Saag, Peter Cram
CONTEXT: Evidence is inconclusive whether a nurse consultation can improve osteoporosis-related patient outcomes. OBJECTIVE: To evaluate whether a nurse consultation immediately after dual-energy x-ray absorptiometry (DXA) produced better osteoporosis-related outcomes than a simple intervention to activate adults in good bone health practices or usual care. DESIGN: Pilot randomized controlled trial, conducted within the larger Patient Activation After DXA Result Notification (PAADRN) trial (NCT01507662)...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28744736/management-of-bone-health-in-postmenopausal-women-on-aromatase-inhibitors-ais-a-single-health-care-system-experience
#20
Douglas Tremblay, Vaibhav Patel, Kenneth M Fifer, Jessica Caro, Olivia Kolodka, John Mandelli, Charles L Shapiro
INTRODUCTION: Aromatase inhibitors (AIs) are the preferred therapy for postmenopausal women with early-stage estrogen receptor-positive breast cancers. However, their use causes bone loss and increased risks of osteoporosis and fractures. METHODS: This is a retrospective review of all postmenopausal women with breast cancer diagnosed and treated with AI between 2010 and 2015. Of the 564 women identified, 319 were eligible. RESULTS: The median age at AI initiation was 65 years (range 51-85 years), and the median duration of AI therapy was 28 months (1-72 months)...
July 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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