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https://www.readbyqxmd.com/read/28775288/a-polypeptide-from-the-junction-region-sequence-of-ews-fli1-inhibits-ewing-s-sarcoma-cells-interacts-with-the-ews-fli1-and-partner-proteins
#1
Krishna Priya Thangaretnam, Gopal Gopisetty, Priya Ramanathan, Thangarajan Rajkumar
The EWS-FLI1 chimeric protein uniquely expressed in Ewing's sarcoma has an obligate role in its aetiology. In our previous report we showed that ectopic expression of the DNA sequences form the junction region (a.a 251-280) can inhibit Ewing's sarcoma cell growth. In the present report, we introduced a peptide (TAT/NLS/EWS-PEP) comprising of thirty amino acids spanning the junction in conjunction with HIV-1-trans-activating (TAT) and nuclear localization signal sequence (NLS). Peptide uptake and localization studies revealed presence of peptide in ~99% of transduced cells and in the nucleus...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739808/experiences-of-hiv-postexposure-prophylaxis-pep-among-highly-exposed-men-who-have-sex-with-men-msm
#2
Romain Palich, Guillaume Martin-Blondel, Lise Cuzin, Jean-Yves Le Talec, Pierre Boyer, Patrice Massip, Pierre Delobel
OBJECTIVES: HIV postexposure prophylaxis (PEP) is indicated after sexual exposure with high risk of transmission. Men who have sex with men (MSM) are the main target of PEP. The aim of our study was to investigate the experience and shortcomings of PEP among people with a high risk of HIV exposure. DESIGN AND METHODS: Subjects with ongoing follow-up for HIV infection and PEP history were selected for the qualitative study. Semistructured interviews were conducted at the patients' homes...
July 24, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28696345/optimal-hiv-postexposure-prophylaxis-regimen-completion-with-single-tablet-daily-elvitegravir-cobicistat-tenofovir-disoproxil-fumarate-emtricitabine-compared-with-more-frequent-dosing-regimens
#3
COMPARATIVE STUDY
Kenneth H Mayer, Daniel Jones, Catherine Oldenburg, Sachin Jain, Marcy Gelman, Shayne Zaslow, Chris Grasso, Matthew J Mimiaga
STRUCTURE: The study evaluated elvitegravir/cobicistat/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) ("Quad pill") for postexposure prophylaxis (PEP). BACKGROUND: HIV-exposed individuals may benefit from PEP, but completion rates have been suboptimal because of regimen complexity and side effects. Newer antiretroviral combinations coformulated as single daily pills may optimize PEP adherence. SETTING: One hundred HIV-uninfected individuals who presented to a Boston community health center after an acute HIV sexual exposure were enrolled and initiated PEP with the daily, single-pill combination Quad pill for a 28-day course...
August 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28657279/knowledge-of-hiv-pep-among-healthcare-workers-in-ireland-2016-room-for-improvement
#4
P Garvey, L Thornton, F Lyons
Post-exposure prophylaxis (PEP) is an important aspect of HIV prevention following potential exposure. We conducted a survey to assess knowledge of HIV PEP, and awareness of HIV PEP resources, among key healthcare professionals, using an anonymous online questionnaire. Twelve (18%) of 68 respondents answered five or more of six knowledge questions correctly; 49 (72%) cited the Emergency Management of Injuries (EMI) toolkit as a resource. Although most respondents were aware of the EMI Toolkit for HIV PEP, the low number of respondents correctly answering knowledge questions suggests a need for training to avoid potential suboptimal HIV PEP use...
January 11, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28631059/trends-in-hiv-risk-testing-and-treatment-among-msm-in-chicago-2004-2014-implications-for-hiv-elimination-planning
#5
Ethan Morgan, Britt Skaathun, Nicola Lancki, Antonio D Jimenez, Jesus Ramirez-Valles, Ramona Bhatia, Stephanie Masiello-Schuette, Nanette Benbow, Nikhil Prachand, John A Schneider
Men who have sex with men (MSM) in the USA continue to have high rates of HIV infection. Increasingly, in addition to behavioral factors, biomedical interventions have been found to play important roles in HIV prevention. In this analysis, we used four waves of cross-sectional data (2004, 2008, 2011, and 2014) from the National HIV Behavioral Surveillance System (NHBS) to examine trends in key behaviors and biomedical interventions among MSM in Chicago (N = 3298). Logistic regression was used to determine changes in behaviors and use of biomedical interventions...
June 19, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28612589/-post-exposure-prophylaxis-against-hiv-do-we-use-our-resources-appropriately
#6
R Escudero-Sánchez, C J Kurt Meier-de-Taboada, E Bartolome-García, P M Rodríguez-de-Bethencourt-Sanjuan, J E Losa-García
OBJECTIVE: Post-exposure prophylaxis (PEP) against human immunodeficiency virus can be occupational, non-occupational or vertical transmission. The aim of our study was to analyse the indication and treatment carried out in a hospital. METHODS: Retrospective observational study that included all patients who received PEP between 2006 and 2014. The project was approved by the Committee for Ethics in Clinical Research. RESULTS: We evaluated 54 PEP, which were started at 11...
June 14, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28605228/sexual-assault-and-hiv-postexposure-prophylaxis-at-an-urban-african-hospital
#7
Eric Munene Muriuki, Joshua Kimani, Zipporah Machuki, James Kiarie, Alison C Roxby
Antiretroviral postexposure prophylaxis (PEP) may be underutilized in sexual assault cases in Kenya. This study evaluated the characteristics of survivors of sexual violence attending the Gender-Based Violence Recovery Center (GBVRC) at the Kenyatta National Hospital and reviewed the uptake, adherence, and outcomes of those initiated on PEP. In a retrospective cohort, data from charts of the assaulted seen at the GBVRC from 2009 to 2012 were abstracted. Data were collected describing sociodemographic characteristics, nature of sexual assault, HIV serostatus, and aspects of the PEP care cascade...
June 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28604443/differences-in-awareness-of-pre-exposure-prophylaxis-and-post-exposure-prophylaxis-among-groups-at-risk-for-hiv-in-new-york-state-new-york-city-and-long-island-ny-2011-2013
#8
Suzan M Walters, Alexis V Rivera, Lila Starbuck, Kathleen H Reilly, Nyasha Boldon, Bridget J Anderson, Sarah Braunstein
BACKGROUND: Pre-exposure prophylaxis (PrEP) to reduce the risk of HIV was approved in 2012 and post-exposure prophylaxis (PEP) in 2005. We report the differences in awareness of PrEP/PEP and factors associated with awareness by examining 3 risk groups (men who have sex with men (MSM), people who inject drugs, and high-risk heterosexuals). METHODS: National HIV Behavioral Surveillance system data collected in New York City (NYC) and Long Island, NY in 2011-2013 were used...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28602843/combination-of-cell-penetrating-peptides-and-heterologous-dna-prime-protein-boost-strategy-enhances-immune-responses-against-hiv-1-nef-antigen-in-balb-c-mouse-model
#9
Somayeh Kadkhodayan, Behnaz Sadat Jafarzade, Seyed Mehdi Sadat, Fateme Motevalli, Elnaz Agi, Azam Bolhassani
To develop a strong HIV specific T-cell response, the HIV-1 Tat and Nef regulatory proteins have been known as attractive antigenic candidates in vaccine design. A peptide transduction domain of Tat (48-60 aa) could act to deliver other therapeutic molecules into different cells. In this line, several cell-penetrating peptides (CPPs) have been designed to transfer DNA, siRNA, polypeptides and proteins into cells through non-covalent approach such as CADY and PEP families. Some studies showed that the endogenous adjuvants including heat shock protein Gp96 could stimulate antigen-specific T cell immune responses...
August 2017: Immunology Letters
https://www.readbyqxmd.com/read/28587607/design-of-a-syndemic-based-intervention-to-facilitate-care-for-men-who-have-sex-with-men-with-high-risk-behaviour-the-syn-bas-in-randomized-controlled-trial
#10
Roel C A Achterbergh, Jannie J van der Helm, Wim van den Brink, Henry J C de Vries
BACKGROUND: Men who have sex with men (MSM) constitute a risk group for sexual transmitted infections (STIs), including HIV. Despite counselling interventions, risk behaviour remains high. Syndemic theory holds that psychosocial problems often co-occur, interact and mutually reinforce each other, thereby increasing high risk behaviours and co-occurring diseases. Therefore, if co-occurring psychosocial problems were assessed and treated simultaneously, this might decrease high risk behaviour and disease...
June 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28480682/adherence-and-characteristics-of-hiv-post-exposure-prophylaxis-for-a-population-in-tel-aviv-of-men-who-have-sex-with-men
#11
Noam Oz, Danny Alon, Gideon Y Stein, Dan Turner
BACKGROUND: Pre-exposure prophylaxis (PrEP) for populations at high risk for human immunodeficiency virus (HIV) is still not available in Israel. OBJECTIVES: To analyze post-exposure prophylaxis (PEP) treatment adherence rates among adult men in Tel Aviv, Israel, who have sex with men (MSM), and to obtain data on the demographics of PEP users, exposure types, timeline of exposure and PEP administration, incidence of side effects, number of treatments per individual, and satisfaction with selected elements of treatment provision...
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28467163/perspectives-on-hiv-pre-and-post-exposure-prophylaxes-prep-and-pep-among-female-and-male-sex-workers-in-mombasa-kenya-implications-for-integrating-biomedical-prevention-into-sexual-health-services
#12
Arjee J Restar, Jack Ume Tocco, Joanne E Mantell, Yves Lafort, Peter Gichangi, Tsitsi B Masvawure, Sophie Vusha Chabeda, Theo G M Sandfort
Pre- and post-exposure prophylaxes (PrEP and PEP) can reduce the risk of HIV acquisition, yet often are inaccessible to and underutilized by most-vulnerable populations, including sex workers in sub-Saharan Africa. Based on in-depth interviews with 21 female and 23 male HIV-negative sex workers in Mombasa, Kenya, we found that awareness and knowledge of PrEP and PEP were low, although willingness to use both was high. Participants felt PrEP would be empowering and give added protection against infection, although some expressed concerns about side effects...
April 2017: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/28456065/improving-hiv-post-exposure-prophylaxis-rates-after-pediatric-acute-sexual-assault
#13
Samantha Schilling, Stephanie A Deutsch, Rebecca Gieseker, Jennifer Molnar, Jane M Lavelle, Philip V Scribano
The purpose of our study was to increase the rate of children with appropriate HIV-PEP regimens among those diagnosed with sexual assault in The Children's Hospital of Philadelphia Emergency Department (ED). The outcome measure was the percent of patients receiving correct HIV-PEP. We retrospectively reviewed 97 charts over 31 months to define the baseline rate of children receiving appropriate HIV-PEP regimens (pre QI-implementation period: 2/2012-8/2014). Among children in which HIV-PEP was indicated following sexual assault, 40% received the recommended 28-day course...
April 26, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28446839/awareness-of-blood-borne-infections-and-burden-of-occupational-exposures-to-blood-and-body-fluids-among-health-care-personnel-in-a-tertiary-care-teaching-hospital
#14
Swetharani, K V Vinod, Abdoul Hamide, Tarun K Dutta, K T Harichandrakumar
BACKGROUND AND OBJECTIVES: Occupational exposures (OEs) to blood and body fluids (BBFs) pose significant risk of transmission of blood-borne infections (BBIs) to health care personnel (HCP) and are grossly underreported. We aimed to study the awareness of BBIs and their prevention, burden of OEs, assess factors contributing to them and their poor reporting and assess the practices for their prevention among HCP. MATERIALS AND METHODS: This cross-sectional study conducted at a tertiary care teaching hospital located in south India used a self-administered questionnaire to assess the awareness of BBIs, attitude and practice of HCP for prevention of OEs, and to quantify the burden of exposures...
September 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28445222/development-of-an-hiv-postexposure-prophylaxis-pep-protocol-for-trainees-engaging-in-academic-global-health-experiences
#15
Gitanjli Arora, Risa M Hoffman
PROBLEM: Global health (GH) education programs have become increasingly common in U.S. medical schools and graduate medical education programs, with growing numbers of medical students, residents, and fellows participating in clinical experiences in settings with high HIV prevalence and limited resources. However, there are no guidelines for provision of HIV postexposure prophylaxis (PEP) to trainees engaging in these academic GH experiences. APPROACH: Faculty of the Global Health Education Programs (GHEP) at the David Geffen School of Medicine at UCLA and GH partner institutions recognized the need for PEP access for trainees engaged in GH experiences...
April 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28442797/pre-and-post-sexual-exposure-prophylaxis-of-hiv-an-update
#16
REVIEW
Yogesh S Marfatia, Sheethal K Jose, Reema R Baxi, Ruchi J Shah
Pitfalls in current HIV prevention strategies include late HIV testing, vulnerability among youth and females; lack of emphasis on treatment, low acceptance of circumcision, and nonavailability of protective vaccines. Continuing high-risk sexual behavior, forceful sex, coercive and nonconsensual sex, rape, and unprotected sexual activities make women the most vulnerable to acquisition of sexually transmitted infection/HIV and necessitates a more radical approach of prevention in high-risk individuals who do not have HIV...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28431556/factors-associated-with-loss-to-follow-up-after-occupational-hiv-exposure-in-cape-town-south-africa-a-retrospective-cohort-study
#17
Nectarios Sophocles Papavarnavas, Kathryn Manning, Fahd Conrad, Milah Govender, Gary Maartens
BACKGROUND: There is limited data on factors associated with loss to follow-up (LTFU) of health care workers (HCWs) following occupational exposure to HIV, and most studies were conducted in an era when poorly tolerated antiretrovirals like zidovudine were used. METHODS: A retrospective cohort study was conducted of HCWs attending a referral hospital's Occupational Health Clinic in Cape Town, South Africa for post-exposure prophylaxis (PEP) during a period when tenofovir was available...
April 21, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28369381/randomized-controlled-trial-of-the-tolerability-and-completion-of-maraviroc-compared-with-kaletra%C3%A2-in-combination-with-truvada%C3%A2-for-hiv-post-exposure-prophylaxis-mipep-trial
#18
Ana Milinkovic, Paul Benn, Alejandro Arenas-Pinto, Nataliya Brima, Andrew Copas, Amanda Clarke, Martin Fisher, Gabriel Schembri, David Hawkins, Andy Williams, Richard Gilson
Objectives: Post-exposure prophylaxis (PEP) for HIV is often poorly tolerated and not completed. Alternative PEP regimens may improve adherence and completion, aiding HIV prevention. We conducted a randomized controlled trial of a maraviroc-based PEP regimen compared with a standard-of-care regimen using ritonavir-boosted lopinavir. Methods: Patients meeting criteria for PEP were randomized to tenofovir disoproxil/emtricitabine (200/245 mg) once daily plus ritonavir-boosted lopinavir (Kaletra ® 400/100 mg) or maraviroc 300 mg twice daily...
June 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28362062/a-novel-online-to-offline-o2o-model-for-pre-exposure-prophylaxis-and-hiv-testing-scale-up
#19
Tarandeep Anand, Chattiya Nitpolprasert, Deondara Trachunthong, Stephen J Kerr, Surang Janyam, Danai Linjongrat, Lisa B Hightow-Weidman, Praphan Phanuphak, Jintanat Ananworanich, Nittaya Phanuphak
INTRODUCTION: PrEP awareness and uptake among men who have sex with men (MSM) and transgender women (TG) in Thailand remains low. Finding ways to increase HIV testing and PrEP uptake among high-risk groups is a critical priority. This study evaluates the effect of a novel Adam's Love Online-to-Offline (O2O) model on PrEP and HIV testing uptake among Thai MSM and TG and identifies factors associated with PrEP uptake. METHODS: The O2O model was piloted by Adam's Love (www...
March 10, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28350554/brief-report-high-sensitivity-and-specificity-of-the-cepheid-xpert-hiv-1-qualitative-point-of-care-test-among-newborns-in-botswana
#20
Maryanne Ibrahim, Sikhulile Moyo, Terence Mohammed, Lucy Mupfumi, Simani Gaseitsiwe, Kenneth Maswabi, Gbolahan Ajibola, Rebecca Gelman, Oganne Batlang, Maureen Sakoi, Chloe Auletta-Young, Joseph Makhema, Shahin Lockman, Roger L Shapiro
BACKGROUND: HIV point-of-care (POC) testing allows for early infant HIV diagnosis and treatment, but POC accuracy at birth and in the setting of antiretroviral prophylaxis for the prevention of mother-to-child HIV transmission is unknown. METHODS: We evaluated the Cepheid Xpert HIV-1 Qual POC test against the Roche Taqman HIV-1 DNA polymerase chain reaction (PCR) platform using dried blood spots from 15 HIV-infected and 75 HIV-exposed uninfected newborns. These infants were screened for HIV at <96 hours of life at 5 hospital maternity wards in Botswana; all infants received postexposure antiretroviral prophylaxis with single-dose nevirapine and zidovudine, and most mothers received 3-drug antiretroviral therapy in pregnancy and at delivery...
August 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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