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https://www.readbyqxmd.com/read/29781568/diastolic-dysfunction-is-associated-with-exercise-impairment-in-patients-with-sickle-cell-anemia
#1
Tarek Alsaied, Omar Niss, Adam W Powell, Robert J Fleck, James F Cnota, Clifford Chin, Punam Malik, Charles T Quinn, Michael D Taylor
BACKGROUND: Left ventricular diastolic dysfunction (DD) is an independent risk factor for mortality in sickle cell anemia (SCA) and is associated with increased extracellular volume (ECV) on cardiac MRI (CMR). Exercise impairment is common in SCA, but its causes and prognostic value are not well understood. OBJECTIVE: To study the effects of DD and ECV on cardiopulmonary exercise test (CPET) in patients with SCA. METHODS AND RESULTS: As part of a prospective study to characterize the cardiomyopathy of SCA (NCT02410811), 20 children and adults with SCA underwent CMR, echocardiography, and cycle ergometer CPET (age range 8-43 years)...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29778968/environmental-risk-factors-associated-with-low-birth-weight-the-case-study-of-the-haifa-bay-area-in-israel
#2
Alina Svechkina, Jonathan Dubnov, Boris A Portnov
BACKGROUND: Low birth weight (LBW) is known to be associated with infant mortality and postnatal health complications. Previous studies revealed strong relationships between LBW rate and several socio-demographic factors, including ethnicity, maternal age, and family income. However, studies of association between LBW rate and environmental risk factors remain infrequent. STUDY METHODS: We retrieved a geo-referenced data set, containing 7216 individual records of children born in 2015 in the Haifa Bay Area in Israel...
May 17, 2018: Environmental Research
https://www.readbyqxmd.com/read/29777722/ca-2-signaling-and-spinocerebellar-ataxia
#3
REVIEW
Chihiro Hisatsune, Kozo Hamada, Katsuhiko Mikoshiba
Spinocerebellar ataxia (SCA) is a neural disorder, which is caused by degenerative changes in the cerebellum. SCA is primarily characterized by gait ataxia, and additional clinical features include nystagmus, dysarthria, tremors and cerebellar atrophy. Forty-four hereditary SCAs have been identified to date, along with >35 SCA-associated genes. Despite the great diversity and distinct functionalities of the SCA-related genes, accumulating evidence supports the occurrence of a common pathophysiological event among several hereditary SCAs...
May 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29773427/microphthalmia-associated-transcription-factor-mitf-promiscuous-staining-patterns-in-fibrohistiocytic-lesions-is-a-potential-pitfall
#4
Sambit K Mohanty, Shivani Sharma, Dinesh Pradhan, Shivani R Kandukuri, Navid Farahani, Catherine Barry, Julie M Wu, David Frishberg, Bonnie Balzer
Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors...
May 11, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29772202/rnp-granule-assembly-via-ataxin-2-disordered-domains-is-required-for-long-term-memory-and-neurodegeneration
#5
Baskar Bakthavachalu, Joern Huelsmeier, Indulekha P Sudhakaran, Jens Hillebrand, Amanjot Singh, Arnas Petrauskas, Devasena Thiagarajan, M Sankaranarayanan, Laura Mizoue, Eric N Anderson, Udai Bhan Pandey, Eric Ross, K VijayRaghavan, Roy Parker, Mani Ramaswami
Human Ataxin-2 is implicated in the cause and progression of amyotrophic lateral sclerosis (ALS) and type 2 spinocerebellar ataxia (SCA-2). In Drosophila, a conserved atx2 gene is essential for animal survival as well as for normal RNP-granule assembly, translational control, and long-term habituation. Like its human homolog, Drosophila Ataxin-2 (Atx2) contains polyQ repeats and additional intrinsically disordered regions (IDRs). We demonstrate that Atx2 IDRs, which are capable of mediating liquid-liquid phase transitions in vitro, are essential for efficient formation of neuronal mRNP assemblies in vivo...
May 16, 2018: Neuron
https://www.readbyqxmd.com/read/29771918/a-hybrid-q-learning-sine-cosine-based-strategy-for-addressing-the-combinatorial-test-suite-minimization-problem
#6
Kamal Z Zamli, Fakhrud Din, Bestoun S Ahmed, Miroslav Bures
The sine-cosine algorithm (SCA) is a new population-based meta-heuristic algorithm. In addition to exploiting sine and cosine functions to perform local and global searches (hence the name sine-cosine), the SCA introduces several random and adaptive parameters to facilitate the search process. Although it shows promising results, the search process of the SCA is vulnerable to local minima/maxima due to the adoption of a fixed switch probability and the bounded magnitude of the sine and cosine functions (from -1 to 1)...
2018: PloS One
https://www.readbyqxmd.com/read/29766928/parent-artery-sacrifice-for-ruptured-aneurysms-in-acute-and-chronic-phases-a-systematic-review
#7
REVIEW
Xianli Lv, Wei Li, Huijian Ge, Hengwei Jin, Hongwei He, Chuhan Jiang, Youxiang Li
Background: Experience with respect to parent vessel sacrifice (PVS) for unclippable/uncoilable ruptured aneurysms is limited. Objective: The aim of the present systematic review was to evaluate the risk of PVS for unclippable/uncoilable ruptured aneurysms. Materials and Methods: The PUBMED and SCIENCEDIRECT databases were searched using "parent vessel occlusion OR parent artery occlusion" AND "acute subarachnoid hemorrhage" till December 27, 2015, and 1 journal was searched from November 1995 to April 2016 for relevant results...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765433/left-ventricular-structural-and-functional-changes-evaluated-by-echocardiography-and-two-dimensional-strain-in-patients-with-sickle-cell-disease
#8
Ricardo Bedirian, Andrea Ribeiro Soares, Maria Christina Maioli, Jussara Fonseca Fernandes de Medeiros, Agnaldo José Lopes, Marcia Bueno Castier
Introduction: Patients with sickle cell disease have increased left ventricular size, which is not usually accompanied by changes in systolic function indexes. We assessed echocardiographic abnormalities present in patients with sickle cell anemia (SCA) and compared echocardiographic parameters to other sickle cell diseases (OSCD). Material and methods: A blind cross-sectional study with 60 patients with SCA and 16 patients with OSCD who underwent transthoracic echocardiography was performed...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29763923/bidirectional-connections-between-depression-and-ataxia-severity-in-spinocerebellar-ataxia-type-3-patients
#9
Min-Ting Lin, Jin-Shan Yang, Ping-Ping Chen, Mei-Zhen Qian, Hui-Xia Lin, Xiao-Ping Chen, Xian-Jin Shang, Dan-Ni Wang, Yu-Chao Chen, Bin Jiang, Yi-Jun Chen, Wan-Jin Chen, Ning Wang, Shi-Rui Gan
BACKGROUND: Spinocerebellar ataxia type 3 (SCA3), which is the most common subtype of SCA worldwide, exhibits common neuropsychological symptoms such as depression. However, the contribution of depression to the severity of SCA3 has not yet been thoroughly investigated. METHODS: The present study investigated the prevalence of depression using Beck depression inventory in 104 molecularly confirmed SCA3 patients from China. The putative risk factors for depression and whether the depression could affect the severity of ataxia were established by multivariable linear regression models...
May 15, 2018: European Neurology
https://www.readbyqxmd.com/read/29760732/comparative-study-on-in-vitro-culture-of-mouse-bone-marrow-mesenchymal-stem-cells
#10
Yuxin Hu, Bin Lou, Xiafang Wu, Ruirui Wu, Huihui Wang, Lanyue Gao, Jingbo Pi, Yuanyuan Xu
In vitro culture of mesenchymal stem cells (MSCs) from mouse bone marrow (BM) has been hampered because of the low yield of MSCs during isolation and the contamination of hematopoietic cells during expansion. The lack of specific mouse BM-MSC markers increases the difficulty. Several techniques have been reported to improve the purity and in vitro growth of mouse BM-MSCs. However, systematic report on comparison of characteristics in primary BM-MSCs between different culture conditions is rare. Here, we studied the effects of oxygen concentrations and initial medium replacement intervals, along with cell passages, on mouse BM-MSCs isolated with differential adhesion method...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29752152/vascularized-dermal-autograft-for-the-treatment-of-irreparable-rotator-cuff-tears
#11
Michael A Stone, Antoine Carre, Nicholas Trasolini, Michael Minneti, Reza Omid
BACKGROUND: Irreparable rotator cuff tears (IRCTs) are a challenging problem with diverse treatment modalities. We propose a technique for the treatment of IRCTs in which a vascularized dermal autograft is transferred to the posterosuperior region of the rotator cuff using the supraclavicular artery (SCA) island flap. MATERIALS AND METHODS: Dissection of 11 fresh cadavers (19 shoulders) was performed, and the SCA island flap was harvested in all specimens. A full-thickness posterosuperior rotator cuff defect was created, and the flap was tunneled under the acromion and secured into position over the defect using multiple suture anchors...
May 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29751893/dynamics-of-dengue-disease-with-human-and-vector-mobility
#12
Murali Krishna Enduri, Shivakumar Jolad
Dengue is a vector borne disease transmitted to humans by Aedes aegypti mosquitoes carrying virus of different serotypes. Dengue exhibits complex spatial and temporal dynamics, influenced by various biological, human and environmental factors. In this work, we study the dengue spread for a single serotype (DENV-1) including statistical models of human mobility with exponential step length distribution, by using reaction-diffusion equations and Stochastic Cellular Automata (SCA) approach. We analyze the spatial and temporal spreading of the disease using parameters from field studies...
June 2018: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/29748701/patient-characteristics-and-emergency-department-factors-associated-with-survival-after-sudden-cardiac-arrest-in-children-and-young-adults-a-cross-sectional-analysis-of-a-nationally-representative-sample-2006-2013
#13
Rie Sakai-Bizmark, Scott M I Friedlander, Emily H Marr, Laurie A Mena, Ismael Corral, Ruey-Kang R Chang
The purpose of the study is to examine (1) nationally representative incidence rates of Emergency Department (ED) visits due to sudden cardiac arrest (SCA) in pediatric and young adult populations, (2) basic characteristics of the ED visits with SCA, and (3) patient and hospital factors associated with survival after SCA. We used the Nationwide Emergency Department Sample from 2006 to 2013. ICD-9-CM diagnostic codes identified ED visits due to SCA for patients ≤ 30 years old. Outcomes included yearly incidence of ED visits for SCA, and survival to hospital discharge...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29748129/the-sarco-endo-plasmic-reticulum-calcium-atpase-sca-1-regulates-the-caenorhabditis-elegans-nicotinic-acetylcholine-receptor-acr-16
#14
Ashley A Martin, Janet E Richmond
Nicotinic acetylcholine receptors (nAChR) are present in many excitable tissues and are found both pre and post-synaptically. Through their non-specific cationic permeability, these nAChRs have excitatory roles in neurotransmission, neuromodulation, synaptic plasticity, and neuroprotection. Thus, nAChR mislocalization or functional deficits are associated with many neurological disease states. Therefore identifying the mechanisms that regulate nAChR expression and function will inform our understanding of normal as well as pathological physiological conditions and offer avenues for potential therapeutic advances...
February 24, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29744323/insulin-sensitivity-inflammation-and-basal-metabolic-rate-in-adults-with-sickle-cell-anemia
#15
Kehinde Sola Akinlade, Ayodeji Samuel Kumuyi, Sheu Kadiri Rahamon, John Ayodele Olaniyi
Background: Chronic inflammation and elevated basal metabolic rate (BMR) are established features of sickle-cell anemia (SCA). However, there is little information on the possible impacts of these afore-mentioned features on glycemia and insulin sensitivity status of this group of people. Aim: This study aims to determine the insulin sensitivity status as well the effect of BMR on glycemia in adults with SCA in steady state. Materials and Methods: Fifty participants comprising 30 adults with SCA in steady state and 20 age- and gender-matched apparently healthy adults with hemoglobin genotype AA (HbAA) genotype that served as controls...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29738110/genotoxic-stress-induces-sca-1-expressing-metastatic-mammary-cancer-cells
#16
Jianlin Gong, Benjamin J Lang, Desheng Weng, Takanori Eguchi, Ayesha Murshid, Thiago J Borges, Sachin Doshi, Baizheng Song, Mary Ann Stevenson, Stuart K Calderwood
We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PGE2) and the activity of the PGE2 receptor EP4. Although largely transient, decaying to low levels in a few days to a week, this phenotype was cumulative with damage and levels of cell markers Sca-1 and ALDH1 increased with treatment dose...
May 8, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29737831/investigation-on-the-linker-length-of-synthetic-zwitterionic-polypeptides-for-improved-nonfouling-surfaces
#17
Chong Zhang, Jianhua Lu, Yingqin Hou, Wei Xiong, Kai Sheng, Hua Lu
Zwitterionic polymers are outstanding nonfouling materials widely used for surface modification. However, works that systematically evaluate the structure-activity relationship of the side chain linker effect with related antifouling abilities are sparse. Here, we generate a series of well-defined zwitterionic polypeptides bearing oligoethylene glycol (EG) linkers in the side chain (P(CB-EGx Glu), x = 1-3) and anchor them on gold surfaces via the grafting-to approach to compare their antifouling performances...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29737427/serum-neurofilament-light-is-increased-in-multiple-system-atrophy-of-cerebellar-type-and-in-repeat-expansion-spinocerebellar-ataxias-a-pilot-study
#18
Carlo Wilke, Friedemann Bender, Stefanie N Hayer, Kathrin Brockmann, Ludger Schöls, Jens Kuhle, Matthis Synofzik
Blood biomarkers in degenerative ataxias are still largely missing. Here, we aimed to provide piloting proof-of-concept that serum Neurofilament light (NfL) could offer a promising peripheral blood biomarker in degenerative ataxias. Specifically, as a marker of neuronal damage, NfL might (1) help to differentiate multiple system atrophy of cerebellar type (MSA-C) from sporadic adult-onset ataxia (SAOA), and (2) show increases in repeat-expansion spinocerebellar ataxias (SCAs) which might be amenable to treatment in the future...
May 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29737257/electrophysiologic-considerations-after-sudden-cardiac-arrest
#19
Prakash Suryanarayana, Hyon-He K Garza, Jacob Klewer, Mathew D Hutchinson
In this review, we discuss electrophysiologic management in SCA survivors, including both pharmacological and invasive therapies.
May 7, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29731776/potential-of-ipsc-derived-mesenchymal-stromal-cells-for-treating-periodontal-disease
#20
K Hynes, R Bright, V Marino, J Ng, P J Verma, S Gronthos, P M Bartold
Mesenchymal stromal cell-like populations have been derived from mouse-induced pluripotent stem cells (miPSC-MSC) with the capability for tissue regeneration. In this study, murine iPSC underwent differentiation towards an MSC-like immunophenotype. Stable miPSC-MSC cultures expressed the MSC-associated markers, CD73, CD105, and Sca-1, but lacked expression of the pluripotency marker, SSEA1, and hematopoietic markers, CD34 and CD45. Functionally, miPSC-MSC exhibited the potential for trilineage differentiation into osteoblasts, adipocytes, and chondrocytes and the capacity to suppress the proliferation of mitogen-activated splenocytes...
2018: Stem Cells International
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