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https://www.readbyqxmd.com/read/29156260/towards-more-ecological-relevance-in-sediment-toxicity-testing-with-fish-evaluation-of-multiple-bioassays-with-embryos-of-the-benthic-weatherfish-misgurnus-fossilis
#1
Benjamin Schreiber, Jonas Fischer, Sabrina Schiwy, Henner Hollert, Ralf Schulz
The effects of sediment contamination on fish are of high significance for the protection of ecosystems, human health and economy. However, standardized sediment bioassays with benthic fish species, that mimic bioavailability of potentially toxic compounds and comply with the requirements of alternative test methods, are still scarce. In order to address this issue, embryos of the benthic European weatherfish (Misgurnus fossilis) were exposed to freeze-dried sediment (via sediment contact assays (SCA)) and sediment extracts (via acute fish embryo toxicity tests) varying in contamination level...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29153773/spectrum-and-outcome-of-patients-who-have-undergone-implantation-of-an-implantable-cardioverter-defibrillator-after-aborted-sudden-cardiac-arrest
#2
Fabrice Extramiana, Benjamin Stordeur, Vincent Furioli, Estelle Gandjbakhch, Nicolas Lellouche, Vincent Algalarrondo, Emilie Varlet, Anne Messali, Eloi Marijon, Antoine Leenhardt
Most of implantable cardioverter defibrillator (ICD) secondary prevention studies have been published 2 decades ago. We aimed to describe a contemporary cohort of patients who have undergone implantation of an ICD after an aborted-sudden cardiac arrest (SCA). We retrospectively evaluated consecutive patients referred to our centers between 2005 and 2013. Predictors of overall mortality or heart transplant were analyzed using Cox proportional hazards models. A total of 250 patients (76.4% male, 48.7 ± 16...
October 20, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29153753/an-easy-assessment-of-frailty-at-baseline-independently-predicts-prognosis-in-very-elderly-patients-with-acute-coronary-syndromes
#3
Oriol Alegre, Francesc Formiga, Ramón López-Palop, Francisco Marín, María T Vidán, Manuel Martínez-Sellés, Antoni Carol, Alessandro Sionis, Pablo Díez-Villanueva, Jaime Aboal, Anna Palau-Vendrel, Héctor Bueno, Angel Perez Rivera, Juan Sanchís, Emad Abu-Assi, Miguel Corbí, Juan C Castillo, Jordi Bañeras, Violeta González-Salvado, Àngel Cequier, Albert Ariza-Solé
BACKGROUND: Information about the impact of frailty in patients with acute coronary syndromes (ACS) is scarce. No study has assessed the prognostic impact of frailty as measured by the FRAIL scale in very elderly patients with ACS. METHODS: The prospective multicenter LONGEVO-SCA registry included unselected patients with ACS aged 80 years or older. A comprehensive geriatric assessment was performed during hospitalization, including frailty assessment by the FRAIL scale...
November 16, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29144792/effect-of-blood-collection-tube-type-and-time-to-processing-on-the-enumeration-and-high-content-characterization-of-circulating-tumor-cells-using-the-high-definition-single-cell-assay
#4
Mariam Rodríguez-Lee, Anand Kolatkar, Madelyn McCormick, Angel D Dago, Jude Kendall, Nils Anders Carlsson, Kelly Bethel, Emily J Greenspan, Shelley E Hwang, Kathryn R Waitman, Jorge J Nieva, James Hicks, Peter Kuhn
CONTEXT: - As circulating tumor cell (CTC) assays gain clinical relevance, it is essential to address preanalytic variability and to develop standard operating procedures for sample handling in order to successfully implement genomically informed, precision health care. OBJECTIVE: - To evaluate the effects of blood collection tube (BCT) type and time-to-assay (TTA) on the enumeration and high-content characterization of CTCs by using the high-definition single-cell assay (HD-SCA)...
November 16, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29142027/underestimation-of-risk-of-carotid-subclinical-atherosclerosis-by-cardiovascular-risk-scores-in-patients-with-psoriatic-arthritis
#5
Jiayun Shen, Steven H Lam, Qing Shang, Chun-Kwok Wong, Edmund K Li, Priscilla Wong, Emily W Kun, Isaac T Cheng, Martin Li, Tena K Li, Tracy Y Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVE: To test the performances of established cardiovascular (CV) risk scores in discriminating subclinical atherosclerosis (SCA) in patients with psoriatic arthritis. METHODS: These scores were calculated: Framingham risk score (FRS), QRISK2, Systematic COronary Risk Evaluation (SCORE), 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD) from the American College of Cardiology and the American Heart Association, and the European League Against Rheumatism (EULAR)-recommended modified versions (by 1...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29141658/thioredoxin-mitigates-radiation-induced-hematopoietic-stem-cell-injury-in-mice
#6
Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J Chen, Phuong L Doan, Nelson J Chao, Yubin Kang
BACKGROUND: Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HSCs) from radiation injury is an important goal in the development of medical countermeasure agents (MCM). We recently identified thioredoxin (TXN) as a novel molecule that has marked protective and proliferative effects on HSCs. In the current study, we investigated the effectiveness of TXN in rescuing mice from a lethal dose of total body radiation (TBI) and in enhancing hematopoietic reconstitution following a lethal dose of irradiation...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29131292/in-hospital-sudden-cardiac-arrest-protocol-analysis
#7
Adrianna Jagosz, Dominika Bursy, Aneta Sobon, Pawel Kiczmer, Maja Copik, Szymon Bialka, Jacek Smereka, Hanna Misiolek, Łukasz Szarpak
BACKGROUND: In-hospital sudden cardiac arrest (SCA) is an event that is linked to high mortality. Data analysis of SCA and the course of in-hospital cardiopulmonary resuscitation (CPR) allows for its better understanding and improvement. AIM: Analysis of cases of SCA and the procedures taken by the medical staff of University Hospital. METHODS: A retrospective analysis of 104 protocols of SCA, from May 2014 to December 2015. Actions taken by medical staff before the arrival of the resuscitation team (RT) and RT proceedings...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29130518/automated-red-blood-cell-exchange-in-preparation-for-filgrastim-mobilization-of-autologous-peripheral-blood-hematopoietic-progenitor-cells-in-a-patient-with-sickle-cell-anemia
#8
Yong Zhao, Jeffrey A Bailey, Jeanne Linden, Patricia St Pierre, Jan Cerny, Michelle Vauthrin, Mindy Greene, Robert Weinstein
Increasing survival of patients with sickle cell anemia (SCA) well into adulthood results in a rising likelihood of developing hematological malignancy. High-dose chemotherapy with autologous hematopoietic progenitor cell (HPC) rescue is standard of care for several hematological malignancies, but the risk of severe or life-threatening vaso-occlusive phenomena during filgrastim mobilization of HPC for collection poses a potential barrier to this approach. We report the use of automated red cell exchange in preparation for filgrastim mobilization in a patient with homozygous SCA...
November 11, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29127678/allogeneic-matched-related-transplantation-for-%C3%AE-thalassemia-and-sickle-cell-anemia
#9
Françoise Bernaudin, Corinne Pondarré, Claire Galambrun, Isabelle Thuret
Allogeneic hematopoietic stem cell transplantation (HSCT) can cure single gene disorders such as thalassemia and sickle cell anemia (SCA). These non-malignant diseases have in common severe hemolytic anemia and high proliferative bone marrow, requiring frequent transfusions. The risk of rejection is high and graft-vs-host disease is not desirable. Important progress has been made in the management of these diseases, including leukocyte depletion of blood products, and chelation therapy, for both diseases, and erythrocytapheresis and hydroxycarbamide for SCA...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29126441/tgf%C3%AE-3-recruits-endogenous-mesenchymal-stem-cells-to-initiate-bone-regeneration
#10
Moyuan Deng, Tieniu Mei, Tianyong Hou, Keyu Luo, Fei Luo, Aijun Yang, Bo Yu, Hao Pang, Shiwu Dong, Jianzhong Xu
BACKGROUND: The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor cells and endothelial cells to participate in tissue regeneration. However, the mechanism of TGFβ3 recruiting MSCs toward bone regeneration has remained obscure. METHODS: We estimated the promigratory property of TGFβ3 on human bone marrow MSCs (hBMSCs) cocultured with the vascular cells (human umbilical artery smooth muscle cells or human umbilical vein endothelial cells) or not by Transwell assay...
November 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29125628/genomics-based-non-invasive-prenatal-testing-for-detection-of-fetal-chromosomal-aneuploidy-in-pregnant-women
#11
REVIEW
Mylène Badeau, Carmen Lindsay, Jonatan Blais, Leon Nshimyumukiza, Yemisi Takwoingi, Sylvie Langlois, France Légaré, Yves Giguère, Alexis F Turgeon, William Witteman, François Rousseau
BACKGROUND: Common fetal aneuploidies include Down syndrome (trisomy 21 or T21), Edward syndrome (trisomy 18 or T18), Patau syndrome (trisomy 13 or T13), Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX) and 47,XYY syndrome (47,XYY). Prenatal screening for fetal aneuploidies is standard care in many countries, but current biochemical and ultrasound tests have high false negative and false positive rates. The discovery of fetal circulating cell-free DNA (ccfDNA) in maternal blood offers the potential for genomics-based non-invasive prenatal testing (gNIPT) as a more accurate screening method...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29124382/use-of-whole-body-ct-to-detect-patterns-of-cpr-related-injuries-after-sudden-cardiac-arrest
#12
Gregor M Dunham, Alexandre Perez-Girbes, Ferdia Bolster, Kellie Sheehan, Ken F Linnau
AIMS AND OBJECTIVES: We have recently implemented a dedicated sudden cardiac arrest (SCA) - whole-body computed tomography (WBCT) protocol to evaluate SCA patients with return of spontaneous circulation (ROSC) following cardiopulmonary resuscitation (CPR). The aim of this study is to evaluate the number and pattern of CPR-related injuries in ROSC patients with SCA-WBCT. METHODS AND MATERIALS: Single-centre retrospective review of 39 patients (13 female; 20 male, mean age 51...
November 9, 2017: European Radiology
https://www.readbyqxmd.com/read/29111027/sequence-configuration-of-spinocerebellar-ataxia-type-8-repeat-expansions-in-a-japanese-cohort-of-797-ataxia-subjects
#13
Yajun Hu, Yuji Hashimoto, Takashi Ishii, Mamut Rayle, Kazumasa Soga, Nozomu Sato, Michi Okita, Miwa Higashi, Kokoro Ozaki, Hidehiro Mizusawa, Kinya Ishikawa, Takanori Yokota
Spinocerebellar ataxia type 8 (SCA8), an autosomal dominant neurodegenerative disorder showing slowly progressive cerebellar ataxia, is caused by a tri-nucleotide CTG repeat expansion (CTGexp) in the SCA8 gene. As the CTGexp is not fully penetrant, the significance of screening CTGexp in ataxia subjects remains obscure. We tested SCA8 CTGexp in a cohort of 797 ataxia subjects, and if present, its sequence configuration was analyzed. CTGexp was found in 16 alleles from 14 individuals, 2 of which was homozygous for CTGexp...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29109712/anaerobic-oxidation-of-ethane-propane-and-butane-by-marine-microbes-a-mini-review
#14
REVIEW
Rajesh Singh, Michael S Guzman, Arpita Bose
The deep ocean and its sediments are a continuous source of non-methane short-chain alkanes (SCAs) including ethane, propane, and butane. Their high global warming potential, and contribution to local carbon and sulfur budgets has drawn significant scientific attention. Importantly, microbes can use gaseous alkanes and oxidize them to CO2, thus acting as effective biofilters. A relative decrease of these gases with a concomitant (13)C enrichment of propane and n-butane in interstitial waters vs. the source suggests microbial anaerobic oxidation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29108926/a-thalidomide-hydroxyurea-hybrid-increases-hbf-production-in-sickle-cell-mice-and-reduces-the-release-of-proinflammatory-cytokines-in-cultured-monocytes
#15
Carolina Lanaro, Carla Franco-Penteado, Fabio H Silva, Kleber Y Fertrin, Jean Leandro Dos Santos, Marlene Wade, Shobha Yerigenahally, Thais R de Melo, Chung Man Chin, Abdullah Kutlar, Steffen E Meiler, Fernando Ferreira Costa
Fetal hemoglobin induction by hydroxyurea therapy is associated with decreased morbidity and mortality in SCA patients, but not all respond to or tolerate hydroxyurea, which provides a rationale for the development of novel HbF inducers as treatment options for SCA. Thalidomide analogs have a combined ability to induce HbF production and to inhibit the release of tumor necrosis factor α. Molecular hybridization of hydroxyurea and thalidomide was used to synthesize 3-(1,3-dioxoisoindolin-2-yl) benzyl nitrate (compound 4C)...
November 3, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/29107535/genetically-encoded-tools-for-optical-dissection-of-the-mammalian-cell-cycle
#16
Asako Sakaue-Sawano, Masahiro Yo, Naoki Komatsu, Toru Hiratsuka, Takako Kogure, Tetsushi Hoshida, Naoki Goshima, Michiyuki Matsuda, Hiroyuki Miyoshi, Atsushi Miyawaki
Eukaryotic cells spend most of their life in interphase of the cell cycle. Understanding the rich diversity of metabolic and genomic regulation that occurs in interphase requires the demarcation of precise phase boundaries in situ. Here, we report the properties of two genetically encoded fluorescence sensors, Fucci(CA) and Fucci(SCA), which enable real-time monitoring of interphase and cell-cycle biology. We re-engineered the Cdt1-based sensor from the original Fucci system to respond to S phase-specific CUL4(Ddb1)-mediated ubiquitylation alone or in combination with SCF(Skp2)-mediated ubiquitylation...
October 25, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29100645/subclavian-axillary-access-for-self-expanding-transcatheter-aortic-valve-replacement-renders-equivalent-outcomes-as-transfemoral
#17
Thomas G Gleason, John T Schindler, Robert C Hagberg, G Michael Deeb, David H Adams, John V Conte, George L Zorn, G Chad Hughes, Jia Guo, Jeffrey J Popma, Michael J Reardon
BACKGROUND: Iliofemoral arterial disease can preclude transfemoral (TF) transcatheter aortic valve replacement (TF-TAVR). Transthoracic access by direct aortic or a transapical approach imparts a greater risk of complications and death than TF access. We hypothesized that subclavian/axillary arterial (SCA) access offers equivalent risks and outcomes as TF access. METHODS: The outcomes of 202 patients from the CoreValve (Medtronic, Minneapolis, MN) United States Pivotal Trial Program treated with SCA access were propensity matched with patients treated with TF access and analyzed...
November 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29100414/the-ros-nf-%C3%AE%C2%BAb-nr4a2-pathway-is-involved-in-h2o2-induced-apoptosis-of-resident-cardiac-stem-cells-via-autophagy
#18
Xingxing Shi, Wenjing Li, Honghong Liu, Deling Yin, Jing Zhao
Cardiac stem cells (CSCs)-based therapy provides a promising avenue for the management of ischemic heart diseases. However, engrafted CSCs are subjected to acute cell apoptosis in the ischemic microenvironment. Here, stem cell antigen 1 positive (Sca-1(+)) CSCs proved to own therapy potential were cultured and treated with H2O2 to mimic the ischemia situation. As autophagy inhibitor, 3-methyladenine (3MA), inhibited H2O2-induced CSCs apoptosis, thus we demonstrated that H2O2 induced autophagy-dependent apoptosis in CSCs, and continued to find key proteins responsible for the crosstalk between autophagy and apoptosis...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097774/altered-b-lymphopoiesis-in-mice-with-deregulated-thrombopoietin-signaling
#19
Amanda E Au, Marion Lebois, Starling A Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T Kile, Kylie D Mason, Ashley P Ng, Warren S Alexander, Emma C Josefsson
Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet number, TPO is important for maintaining proper hematopoietic stem cell (HSC) function. It was previously shown that a number of lymphoid genes were upregulated in HSCs from Tpo (-/-) mice. We investigated if absent or enhanced TPO signaling would influence normal B-lymphopoiesis. Absent TPO signaling in Mpl (-/-) mice led to enrichment of a common lymphoid progenitor (CLP) signature in multipotential lineage-negative Sca-1(+)c-Kit(+) (LSK) cells and an increase in CLP formation...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093008/interleukin-27-exerts-its-antitumor-effects-by-promoting-differentiation-of-hematopoietic-stem-cells-to-m1-macrophages
#20
Yukino Chiba, Izuru Mizoguchi, Junichi Furusawa, Hideaki Hasegawa, Mio Ohashi, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto
The interleukin (IL)-27 promotes expansion and differentiation of hematopoietic stem cells into myeloid progenitor cells. Many tumor-infiltrating myeloid cells exert immunosuppressive effects but we hypothesized that the myeloid cells induced by IL-27 would have antitumor activity. In this study we corroborated this hypothesis as investigated in two distinct mouse transplantable tumor models. Malignant mouse cells engineered to express IL-27 exhibited reduced tumor growth in vivo. Correlated with this effect was a significant increase in the number of tumor-infiltrating CD11b+ myeloid cells exhibiting a reduced immunosuppressive activity...
November 1, 2017: Cancer Research
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