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https://www.readbyqxmd.com/read/29339080/prostate-cancer-disseminated-tumor-cells-are-rarely-detected-in-the-bone-marrow-of-localized-patients-undergoing-radical-prostatectomy-across-multiple-rare-cell-detection-platforms
#1
Heather J Chalfin, Stephanie A Glavaris, Paymaneh D Malihi, Jamie M Sperger, Michael A Gorin, Changxue Lu, C Rory Goodwin, Yan Chen, Emily A Caruso, Ruth Dumpit, Peter Kuhn, Joshua M Lang, Peter S Nelson, Jun Luo, Kenneth J Pienta
PURPOSE: Prostate circulating tumor cells escape into the peripheral blood and enter the bone marrow as disseminated tumor cells, representing an early step before conventionally detectable metastasis. It is unclear how frequently this occurs in localized disease, and existing detection methods rely on epithelial markers with low specificity and sensitivity. Here we employed multiple methodologies of disseminated tumor cell detection in bone marrow harvested at radical prostatectomy. MATERIALS AND METHODS: Bone marrow was harvested from 208 clinically localized patients, 16 controls, and 5 metastatic patients, with peripheral blood from 37 metastatic patients...
January 12, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29332239/which-parameters-are-relevant-in-sagittal-balance-analysis-of-the-cervical-spine-a-literature-review
#2
REVIEW
Fong Poh Ling, T Chevillotte, A Leglise, W Thompson, C Bouthors, Jean-Charles Le Huec
INTRODUCTION: Cervical spine is part of the spine with the most mobility in the sagittal plane. It is important for surgeons to have reliable, simple and reproducible parameters to analyse the cervical. MATERIAL AND METHOD: This study is a systematic review and a critique of current parameters to help improve the study of cervical spinal balance. We conducted a systematic search of PUBMED/MEDLINE for literature published since January 2014. Only studies written in English and containing abstracts were considered for inclusion...
January 13, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29331960/pregnancy-loss-and-carotid-intima-media-thickness-in-mexican-women
#3
Sandra A Hartasanchez, Mario Flores-Torres, Adriana Monge, Elsa Yunes, Beatriz Rodriguez, Carlos Cantu-Brito, Daniela Colaci, Hector Lamadrid-Figueroa, Ruy Lopez-Ridaura, Martin Lajous
BACKGROUND: Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on early markers of cardiovascular disease risk. METHODS AND RESULTS: Cross-sectional analysis of 1767 disease-free women from the MTC (Mexican Teachers' Cohort) who had been pregnant was used to evaluate the relationship between pregnancy loss and carotid intima-media thickness (IMT)...
January 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29329075/anticoagulant-polyurethane-substrates-modified-with-poly-2-methacryloyloxyethyl-phosphorylcholine-via-si-ratrp
#4
Cheng Chi, Baohong Sun, Ninglin Zhou, Ming Zhang, Xiaohong Chu, Ping Yuan, Jian Shen
A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl3/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coupling agent 3-chloropropyltrimethoxysilane (CPTM), chlorhexidine acetate (CA) and lanthanum(III) worked as ligands of copper ions as a whole during RATRP process...
January 8, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29325610/autosomal-dominant-cerebellar-ataxias
#5
Andrew Mundwiler, Vikram G Shakkottai
Spinocerebellar ataxias (SCAs) are a genetically diverse group of dominantly inherited disorders that share clinical features that result from dysfunction and degeneration of the cerebellum and its associated pathways. Although nearly 40 genes are currently recognized to result in SCA, shared mechanisms for disease pathogenesis exist among subsets of the SCAs. The most common SCAs result from a glutamine-encoding CAG repeat in the respective disease genes. This chapter discusses the varied genetic etiology of SCA and attempts to categorize these disorders based on shared mechanisms of disease...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29325609/the-cag-polyglutamine-repeat-diseases-a-clinical-molecular-genetic-and-pathophysiologic-nosology
#6
Colleen A Stoyas, Albert R La Spada
Throughout the genome, unstable tandem nucleotide repeats can expand to cause a variety of neurologic disorders. Expansion of a CAG triplet repeat within a coding exon gives rise to an elongated polyglutamine (polyQ) tract in the resultant protein product, and accounts for a unique category of neurodegenerative disorders, known as the CAG-polyglutamine repeat diseases. The nine members of the CAG-polyglutamine disease family include spinal and bulbar muscular atrophy (SBMA), Huntington disease, dentatorubral pallidoluysian atrophy, and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29324880/edag-promotes-the-expansion-and-survival-of-human-cd34-cells
#7
Ke Zhao, Wei-Wei Zheng, Xiao-Ming Dong, Rong-Hua Yin, Rui Gao, Xiu Li, Jin-Fang Liu, Yi-Qun Zhan, Miao Yu, Hui Chen, Chang-Hui Ge, Hong-Mei Ning, Xiao-Ming Yang, Chang-Yan Li
EDAG is multifunctional transcriptional regulator primarily expressed in the linloc-kit+Sca-1+ hematopoietic stem cells (HSC) and CD34+ progenitor cells. Previous studies indicate that EDAG is required for maintaining hematopoietic lineage commitment balance. Here using ex vivo culture and HSC transplantation models, we report that EDAG enhances the proliferative potential of human cord blood CD34+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. Moreover, EDAG overexpression induces rapid entry of CD34+ cells into the cell cycle...
2018: PloS One
https://www.readbyqxmd.com/read/29324642/antibacterial-and-antioxidant-capacities-and-attenuation-of-lipid-accumulation-in-3t3-l1-adipocytes-by-low-molecular-weight-fucoidans-prepared-from-compressional-puffing-pretreated-sargassum-crassifolium
#8
Chun-Yung Huang, Chia-Hung Kuo, Chia-Hsin Lee
In this study, we extracted fucoidan from compressional-puffing-pretreated Sargassum crassifolium by hot water. The crude extract of fucoidan (SC) was degraded by various degradation reagents and four low-molecular-weight (LMW) fucoidans, namely SCO (degradation by hydrogen peroxide), SCA (degradation by ascorbic acid), SCOA (degradation by hydrogen peroxide + ascorbic acid), and SCH (degradation by hydrogen chloride) were obtained. The degradation reagents studied could effectively degrade fucoidan into LMW fucoidans, as revealed by intrinsic viscosity, agarose gel electrophoresis, and molecular weight analyses...
January 11, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29322371/relationship-of-parental-genetic-distance-with-heterosis-and-specific-combining-ability-in-sesame-sesamum-indicum-l-based-on-phenotypic-and-molecular-marker-analysis
#9
Sarita K Pandey, Tapash Dasgupta, Abhishek Rathore, Anilkumar Vemula
The genetic distance analysis for selection of suitable parents has been established and effectively used in many crops; however, there is dearth of conclusive report of relationship of genetic distance analysis with heterosis in sesame. In the present study, an attempt was made to estimate the associations of genetic distances using SSR (GDSSR), seed-storage protein profiling (GDSDS) and agro-morphological traits (GDMOR) with hybrid performance. Seven parents were selected from 60 exotic and Indian genotypes based on genetic distance from clustering pattern based on SSR, seed-storage protein, morphological traits and per se performance...
January 10, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29321486/new-insights-on-basivenal-sclerites-using-3d-tools-and-homology-of-wing-veins-in-odonatoptera-insecta
#10
Lauriane Jacquelin, Laure Desutter-Grandcolas, Ioana Chintauan-Marquier, Renaud Boistel, Daran Zheng, Jakub Prokop, André Nel
Being implied in flight, mimetism, communication, and protection, the insect wings were crucial organs for the mega diversification of this clade. Despite several attempts, the problem of wing evolution remains unresolved because the basal parts of the veins essential for vein identification are hidden in the basivenal sclerites. The homologies between wing characters thus cannot be accurately verified, while they are of primary importance to solve long-standing problems, such as the monophyly of the Palaeoptera, viz...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318784/divalproex-sodium-modulates-nuclear-localization-of-ataxin-3-and-prevents-cellular-toxicity-caused-by-expanded-ataxin-3
#11
Zi-Jian Wang, Aoife Hanet, Daniel Weishäupl, Inês M Martins, Anna S Sowa, Olaf Riess, Thorsten Schmidt
BACKGROUND & AIMS: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal dominantly inherited neurodegenerative disorder and the most common form of SCA worldwide. It is caused by the expansion of a polyglutamine (polyQ) tract in the ataxin-3 protein. Nuclear localization of the affected protein is a key event in the pathology of SCA3 via affecting nuclear organization, transcriptional dysfunction, and seeding aggregations, finally causing neurodegeneration and cell death...
January 9, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29318647/realizing-effectiveness-across-continents-with-hydroxyurea-enrollment-and-baseline-characteristics-of-the-multicenter-reach-study-in-sub-saharan-africa
#12
Patrick T McGann, Thomas N Williams, Peter Olupot-Olupot, George A Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Santos, Léon Tshilolo, Russell E Ware
Despite its well-described safety and efficacy in the treatment of sickle cell anemia (SCA) in high-income settings, hydroxyurea remains largely unavailable in sub-Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open-label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub-Saharan African countries...
January 10, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29318626/trends-and-predictors-of-implantable-cardioverter-defibrillator-implantation-after-sudden-cardiac-arrest-insight-from-the-national-inpatient-sample
#13
Muhammad Bilal Munir, Fahad Alqahtani, Sami Aljohani, Ashwin Bhirud, Sujal Modi, Mohamad Alkhouli
BACKGROUND: Implantable cardioverter defibrillator (ICD) has a class IA indication in survivors of sudden cardiac arrest (SCA) provided no reversible cause is identified. We sought to determine trends and predictors of ICD implant in SCA patients from a national sample of United States population. METHODS AND RESULTS: Data was gathered from National Inpatient Sample (NIS) from January 2003 to December 2014. All patients ≥ 18 years of age with a primary discharge diagnosis of SCA, ventricular fibrillation (VF), ventricular flutter, and ventricular tachycardia (VT) were included...
January 9, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29317981/percutaneous-intervention-of-a-single-coronary-artery-in-the-setting-of-acute-coronary-syndrome
#14
Mohammady Shahin, Nooraldaem Yousif, Thomas F Luscher, Slayman Obeid
Performing intervention of a single coronary artery (SCA) is challenging and technically difficult since a severe complication may be catastrophic if occurred. It requires a proper selection of instruments and well experienced operator to perform the intervention. However, a definitive standardization treatment for those patients is difficult; each case should be treated individually, according to the anatomical variations. We present three rare cases of SCA in setting of acute coronary syndrome (ACS) and culprit lesion in right coronary artery (RCA), treated successfully with percutaneous coronary intervention...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29316893/frequency-of-sca8-sca10-sca12-sca36-fxtas-and-c9orf72-repeat-expansions-in-sca-patients-negative-for-the-most-common-sca-subtypes
#15
Gülsah Aydin, Gabriele Dekomien, Sabine Hoffjan, Wanda Maria Gerding, Jörg T Epplen, Larissa Arning
BACKGROUND: Spinocerebellar ataxia (SCA) subtypes are often caused by expansions in non-coding regions of genes like SCA8, SCA10, SCA12 and SCA36. Other ataxias are known to be associated with repeat expansions such as fragile X-associated tremor ataxia syndrome (FXTAS) or expansions in the C9orf72 gene. When no mutation has been identified in the aforementioned genes next-generation sequencing (NGS)-based diagnostics may also be applied. In order to define an optimal diagnostic strategy, more information about the frequency and phenotypic characteristics of rare repeat expansion disorders associated with ataxia should be at hand...
January 9, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29309781/technical-feasibility-diagnostic-yield-and-safety-of-micro-forceps-biopsies-during-eus-evaluation-of-pancreatic-cystic-lesions-with-video
#16
Chetan Mittal, Joshua C Obuch, Hazem Hammad, Steven A Edmundowicz, Sachin Wani, Raj J Shah, Brian C Brauer, Augustin R Attwell, Jeffrey B Kaplan, Mihir S Wagh
BACKGROUND AND AIMS: Through-the-needle micro forceps are a recent addition to the EUS armamentarium for evaluation of pancreatic cystic lesions (PCLs). The main aim of this study was to assess the technical feasibility, diagnostic yield and safety of EUS-guided micro forceps biopsy for PCLs. METHODS: Our electronic endoscopy database was queried to identify patients who underwent EUS-FNA of PCLs and micro forceps biopsies, during the same procedure. The wall of the cyst was biopsied with the micro forceps through the 19-gauge needle and cyst fluid was collected for cytology, and CEA levels...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309564/role-of-syncope-in-predicting-adverse-outcomes-in-patients-with-suspected-brugada-syndrome-undergoing-standardized-flecainide-testing
#17
Juan Pablo Flórez, Daniel García, Irene Valverde, José Rubín, Diego Pérez, Mar González-Vasserot, Julián Reguero, Jesús María de la Hera, Pablo Avanzas, Juan Gómez, Eliecer Coto, César Morís, David Calvo
Aims: Sensitivity to flecainide testing results in suboptimal findings in patients with Brugada syndrome (BrS), leading to safety concerns. Because cardiac syncope effectively predicts outcomes in BrS, we aimed to explore its predictive value in a large cohort of negative and positive responders (NR and PR) to standard flecainide testing. Methods and results : We analysed the data of 251 consecutive patients, 177 NR vs. 74 PR, to flecainide testing, performed according to standard recommendations...
December 22, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29307587/cd8-t-cells-and-ifn-%C3%AE-induce-autoimmune-myelofibrosis-in-mice
#18
Yuan Yao, Liang Li, Shu-Han Yang, Cai-Yue Gao, Liang-Huan Liao, Yu-Qing Xie, Xue-Ying Yin, Yan-Qing Yang, Yun-Yun Fei, Zhe-Xiong Lian
Myelofibrosis usually occurs either as a part of a myelodysplastic syndrome or in conjunction with neoplasia. It is not commonly thought of an autoimmune disease. We reported that p40-/-IL-2Rα-/- (interleukin-12p40 and interleukin-2 receptor alpha double knockout) mice, a mouse model of human primary biliary cholangitis, exhibited features consistent with autoimmune myelofibrosis, including anemia associated with bone marrow fibrosis, and extramedullary hematopoiesis (EMH) including LSK (Lineage-c-Kit+Sca-1+) cells in spleen, liver and peripheral blood...
January 4, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29307455/decellularized-versus-standard-pulmonary-allografts-in-the-ross-procedure-propensity-matched-analysis
#19
Francisco D A da Costa, Jonathan R G Etnel, Efstratios I Charitos, Hans-Hinrich Sievers, Ulrich Stierle, Daniele Fornazari, Johanna J M Takkenberg, Ad J J C Bogers, M Mostafa Mokhles
BACKGROUND: It is hypothesized that decellularization of allografts used for right ventricular outflow tract reconstruction may result in decreased valve deterioration. This study compared the durability of fresh decellularized pulmonary allografts with standard cryopreserved pulmonary allografts in patients undergoing the Ross procedure. METHODS: The Ross procedure was performed in 144 patients with decellularized allografts (DA) from 2005 to 2014 and in 619 with standard cryopreserved allografts (SCA) from 1990 to 2014...
January 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29306107/leukemia-cells-impair-normal-hematopoiesis-and-induce-functionally-loss-of-hematopoietic-stem-cells-through-immune-cells-and-inflammation
#20
Ping Cui, Yuhua Zhang, Maoxiang Cui, Zhihong Li, Guang Ma, Rufeng Wang, Ning Wang, Shujuan Huang, Jie Gao
Bone marrow (BM) failure is often seen in leukemia patients, indicating an abnormal hematopoietic process. However, hematopoiesis in leukemic milieus is largely unknown. In the present study, we utilized one of the most frequent leukemogenic translocations MLL-AF9 to induce leukemia and investigated the hematopoiesis and the activity of hematopoietic stem and progenitor cells (HSPCs) in a leukemic milieu. We found that the phenotypes of the non-leukemic population in leukemic BM were drastically different than normal BM, including blockage of differentiation and a drastically reduced Lin-/Sca+/c-kit+ (LSK) population that contains all HSPCs in leukemic BM...
January 2, 2018: Leukemia Research
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