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Kimberly A Yonkers, Susan G Kornstein, Ralitza Gueorguieva, Brian Merry, Kari Van Steenburgh, Margaret Altemus
IMPORTANCE: Serotonin reuptake inhibitors (SRIs) are efficacious treatments for premenstrual dysphoric disorder (PMDD) when given daily or for half of the menstrual cycle during the luteal phase. Preliminary studies suggest that SRI treatment can be shortened to the interval from symptom onset through the beginning of menses. OBJECTIVE: To determine the efficacy of symptom-onset dosing with the SRI sertraline hydrochloride for treatment of PMDD. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, placebo-controlled, multisite, parallel-group randomized clinical trial conducted September 1, 2007, to February 29, 2012, at 3 university medical centers...
October 2015: JAMA Psychiatry
Xiaofang Zhou, An Zheng, Jiaheng Yin, Rudan Chen, Xianyang Zhao, Wei Xu, Wenqing Cheng, Tian Xia, Simon Lin
BACKGROUND: Consumer-generated content, such as postings on social media websites, can serve as an ideal source of information for studying health care from a consumer's perspective. However, consumer-generated content on health care topics often contains spelling errors, which, if not corrected, will be obstacles for downstream computer-based text analysis. OBJECTIVE: In this study, we proposed a framework with a spelling correction system designed for consumer-generated content and a novel ontology-based evaluation system which was used to efficiently assess the correction quality...
2015: JMIR Medical Informatics
Jonathon Holland, Madhavi Bhogle
BACKGROUND: Depression within the geriatric patient population is an important issue as it is associated with increased mortality. Such depression may have a different aetiology to that in younger patients and be associated with comorbid chronic physical health problems or cognitive impairment. However, there is no specific UK guideline for the treatment of depression within elderly patients. The first-line pharmacological treatment recommended by the National Institute for Health and Care Excellence (NICE) is to use a serotonin-selective reuptake inhibitor (SSRI)...
September 2013: Psychiatria Danubina
I Amundsen, Å M L Oiestad, D Ekeberg, L Kristoffersen
An ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the determination of fifteen basic pharmaceuticals, for analysis of post- and ante-mortem whole blood samples. The following compounds were included: amitriptyline and its metabolite nortriptyline, trimipramine, mianserin, mirtazapine, citalopram, paroxetine, sertraline, and venlafaxine (all antidepressants), levomepromazine and quetiapine (antipsychotics), ketobemidone and tramadol (analgesics), alimemazine (sedative antihistamine), and metoprolol (beta-blocker)...
May 15, 2013: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Cynthia A Munro, Crystal Flynn Longmire, Lea T Drye, Barbara K Martin, Constantine E Frangakis, Curtis L Meinert, Jacobo E Mintzer, Anton P Porsteinsson, Peter V Rabins, Paul B Rosenberg, Lon S Schneider, Daniel Weintraub, Constantine G Lyketsos
OBJECTIVES: Although many depressed patients with Alzheimer disease (AD) are treated with antidepressants, the effect of such treatment on cognitive performance in these patients is not known. The authors report cognitive outcomes in patients with depression of AD (dAD) after a 24-week trial of sertraline or placebo. DESIGN: Placebo-controlled, randomized, double-blind trial. SETTING: Outpatient memory clinics at five academic medical centers in the United States...
December 2012: American Journal of Geriatric Psychiatry
M Colotto, F Vinci, N Vo Hong, O Raimo, A Castello, A Carnovale, A Paciaroni, P Coletta
Selective Serotonin Reuptake Inhibitors (SSRI) are an effective treatment for depressive disorder. Nevertheless, there is evidence suggesting a negative effect of these drugs on the lipid profile of the patients. We carried out a systematic review of the literature evaluating the influence of therapy with SSRI on lipid profile. Data source was MEDLINE. Clinical trials, prospective studies, retrospective studies and reviews published until November 2011 were considered. We identified twelve studies published from 1994 to 2011, of which four were randomized clinical trials, six were prospective studies and two were retrospective studies...
2012: La Clinica Terapeutica
Lubomira Izáková, Ivan Andre, Angelos Halaris
Several studies have demonstrated the effectiveness of adjunctive antidepressant drug therapy to improve the depressive or negative symptoms of schizoaffective disorder, however, monotherapy with atypical antipsychotics may be advantageous. We compared the efficacy and safety of risperidone monotherapy versus combination therapy of haloperidol with sertaline for the acute treatment of schizoaffective disorder, depressed type. This is an open label study of 52 female inpatients randomly assigned to risperidone alone (N = 26) or haloperidol in combination with sertraline (N = 26) for 12 weeks...
2009: Neuropsychiatric Disease and Treatment
John Lekakis, Ignatios Ikonomidis, Zoi Papoutsi, Paraskevi Moutsatsou, Maria Nikolaou, John Parissis, Dimitrios Th Kremastinos
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) exert cardioprotective effects. We examined whether SSRIs a) modulate endothelial cell expression of vascular cell adhesion molecule (VCAM-1), intracellular adhesion molecule (ICAM-1) and adhesiveness to U937 monocytes, b) reduce the circulating levels of these adhesion molecules in vivo. METHODS: We assessed the effect of SSRIs, (citalopram, fluvoxamine and fluoxetine), on TNF-alpha-induced expression of VCAM-1 and ICAM-1 in human aorta endothelial cells and adhesiveness to U937 monocytes...
March 4, 2010: International Journal of Cardiology
Kalpana K Reddy, Benjamin Lefkove, Lan Bo Chen, Baskaran Govindarajan, Arkaitz Carracedo, Guillermo Velasco, Carol O Carrillo, Sulochana S Bhandarkar, Michael J Owens, Fatima Mechta-Grigoriou, Jack L Arbiser
Melanoma is a common malignancy which is poorly responsive to chemotherapy and radiation. One of the major reasons melanoma responds poorly to these modalities is constitutive expression of Akt, which protects against apoptosis. The antidepressant sertraline was found to be a potent cytotoxic agent against A375 human melanoma. To determine the mechanism by which sertraline kills melanoma cells, Western blot analysis of signaling molecules, including phosphorylated Akt, caspase 9 and phospho-p70 S6 kinase was performed...
August 2008: Pigment Cell & Melanoma Research
Stefano Pallanti, Sara Masetti, Silvia Bernardi, Alice Innocenti, Mariana Markella, Eric Hollander
Diamond-Blackfan Anemia (DBA) is a congenital erythroid aplasia characterized as a normochromic macrocytic anemia with a selective deficiency in red blood cell precursors in otherwise normocelullar bone marrow. DBA is known to be associated with mental retardation and learning disabilities. Although comorbidities with other psychiatric conditions have not been reported in the existing literature, we report in this paper a case of a DBA patient with previously undiagnosed comorbidity of obsessive compulsive disorder (OCD), successfully treated with sertaline 200 mg/day and valproic acid 600 mg/day...
2008: Clinical Practice and Epidemiology in Mental Health: CP & EMH
O Oner, P Oner
We present the treatment of three very young preschool patients (four- to five-year old) with obsessive-compulsive disorder (OCD). Two of the patients had severe ego-dystonic obsessions with sexual, aggressive, religious themes and forbidden thoughts, while the other one had contamination obsession and cleaning compulsions. Physical and neurological examination and laboratory work-up did not reveal any abnormalities. The symptoms resolved after sertaline monotherapy up to 50 mg/day and sertraline plus risperidone 0...
September 2008: Journal of Psychopharmacology
Sheila A Doggrell
The choice of treatment after failure of selective serotonin re-uptake inhibitors in the treatment of depression largely depends on the preferences of the physician. The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) trials set out to rationalise the treatment of depression after the failure of citalopram. When subjects who were unresponsive or intolerant to citalopram were switched to sustained-release bupropion, sertaline or extended-release venlafaxine, remission rates were similar (21, 18 and 25%, respectively)...
August 2006: Expert Opinion on Pharmacotherapy
Surachai Likasitwattanakul
Serotonin syndrome is a rare but potentially fatal complication of drugs that have effects on central nervous system serotonin. It is characterized by sudden onset of altered mental status, increased neuromuscular activity and autonomic instability. The author reports a child with suprasellar region tumor who presented with depression and obsessive-compulsive disorder and received a combination of sertaline (selective serotonin reuptake inhibitor) and clomipramine (tricyclic antidepressant). Symptoms of serotonin syndrome occurred within 24 hours after increasing the dose of sertaline...
July 2005: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Shufeng Zhou, Eli Chan, Shen-Quan Pan, Min Huang, Edmund J D Lee
There is a worldwide increasing use of herbs which are often administered in combination with therapeutic drugs, raising the potential for herb-drug interactions. St John's wort (Hypericum perforatum) is one of the most commonly used herbal antidepressants. A literature search was performed using Medline (via Pubmed), Biological Abstracts, Cochrane Library, AMED, PsycINFO and Embase (all from their inception to September 2003) to identify known drug interaction with St John's wort. The available data indicate that St John's wort is a potent inducer of CYP 3A4 and P-glycoprotein (PgP), although it may inhibit or induce other CYPs, depending on the dose, route and duration of administration...
June 2004: Journal of Psychopharmacology
A A Izzo
St. John's Wort (SJW, Hypericum perforatum) is effective in mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile. However, numerous reports indicate the possibility of important interactions with prescribed drugs. SJW has been shown to lower the plasma concentration (and/or the pharmacological effect) of a number of drugs including alprazolam, amitriptyline, cyclosporine, digoxin, fexofenadine, indinavir, irinotecan, methadone, nevirapine, simvastatin, tacrolimus, theophylline, warfarin, phenprocoumon and oral contraceptives...
March 2004: International Journal of Clinical Pharmacology and Therapeutics
Adam Czapliński, Andreas J Steck, Peter Fuhr
A tic is an involuntary, sudden, rapid, recurrent, nonrrhythmic, stereotyped, motor movement or vocalization. This paper reviews clinical, pathophysiological, epidemiological and treatment issues of tic disorders. The clinical presentation of tic disorders with simple and complex motor or vocal tics is reviewed in detail. The most common psychiatric comorbid conditions, such as personality disorder (PD), Obsessive-Compulsive Disorder (OCD), Self-Destructive Behavior (SDB) and Attention Deficit Hyperactivity Disorder (ADHD) are presented too...
May 2002: Neurologia i Neurochirurgia Polska
A A Izzo, E Ernst
Despite the widespread use of herbal medicines, documented herb-drug interactions are sparse. We have reviewed the literature to determine the possible interactions between the seven top-selling herbal medicines (ginkgo, St John's wort, ginseng, garlic, echinacea, saw palmetto and kava) and prescribed drugs. Literature searches were performed using the following databases: Medline (via Pubmed), Cochrane Library, Embase and phytobase (all from their inception to July 2000). All data relating to herb-drug interactions were included regardless of whether they were based on case reports, case series, clinical trials or other types of investigation in humans...
2001: Drugs
J Higley, M Hasert, S Suomi, M Linnoila
Many monkeys that are reared without adult influence, with only peers, voluntarily consume alcohol in amounts producing intoxication on a relatively regular basis. Using a cross-over design, eight adolescent, peer-reared rhesus monkeys were allowed unfettered access to an 8.4% ethanol solution and treated with 20 mg/kg/24 h of sertraline during three phases: home-cage, social separation, and reunion with cage-mates. Although there was no immediate effect, sertraline reduced alcohol consumption beginning the second week of home-cage treatment, but only in subjects that consumed large amounts of alcohol...
June 1998: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
F Cugurra
Different types of depression require adequate treatment. From the most recent MAO inhibitors we go on to tricyclic antidepressants, to the second generation (amoxapine, buspirone, venlafaxine), and to selective inhibitors of 5HT reuptake (fluoxetine and its derivates, again venlafaxine, sertaline). Indications for lithium remain unchanged.
October 1995: La Clinica Terapeutica
M A Graber, T B Hoehns, P J Perry
OBJECTIVE: To report a serious drug interaction possibly occurring with the monoamine oxidase inhibitor phenelzine and the selective serotonin reuptake inhibitor sertraline. CASE SUMMARY: A 61-year-old woman with treatment-refractory major depressive disorder was being treated unsuccessfully with lithium, phenelzine, thioridazine, and doxepin. Sertaline 100 mg/d was added to the patient's therapy. Within three hours of ingesting the first dose, the patient experienced a dramatic increase in her temperature, pulse, and respirations along with labile blood pressure, and symptoms of rigidity, diaphoresis, shivering, and decreased sensorium...
June 1994: Annals of Pharmacotherapy
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