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Flaviana Di Lorenzo, Alba Silipo, Irene Bianconi, Nicola Ivan Lore', Andrea Scamporrino, Luisa Sturiale, Domenico Garozzo, Rosa Lanzetta, Michelangelo Parrilli, Alessandra Bragonzi, Antonio Molinaro
Pseudomonas aeruginosa, the major pathogen involved in lethal infections in cystic fibrosis (CF) population, is able to cause permanent chronic infections that can persist over the years. This ability to chronic colonize CF airways is related to a series of adaptive bacterial changes involving the immunostimulant lipopolysaccharide (LPS) molecule. The structure of LPSs isolated from several P. aeruginosa strains showed conserved features that can undergo chemical changes during the establishment of the chronic infection...
February 2015: Molecular Immunology
Jeffrey S Wagener, Aree A Headley
Cystic fibrosis is a genetic disease that typically produces malnutrition and chronic respiratory infections. Prolonged bronchial obstruction, infection, and inflammation result in bronchiectstasis and permanent lung damage. Most cystic fibrosis patients die because of this progressive respiratory disease. Thus, in the absence of a cure, effective respiratory therapy is the primary means to extend and improve the quality of life for the cystic fibrosis patient. Aerosol therapy, airway clearance techniques, and noninvasive ventilation can all improve quality of life and possibly extend survival...
March 2003: Respiratory Care
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