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Intragam p

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https://www.readbyqxmd.com/read/29530406/unified-infusion-rates-for-10-intravenous-immunoglobulin
#1
Philip Crispin, Maria Burgess, Amy Beath
Although manufacturers recommend varying infusion rates for differing intravenous immunoglobulin products (IVIg), there may be improved efficiency and reduced potential for error with the application of a single infusion policy for all IVIg products. During the transition from a 6% to a 10% IVIg, we prospectively evaluated patient reported adverse reactions to IVIg with the 10% product (Intragam 10) given at a rate faster than recommended by the manufacturer. While there was a significant increase in the rate of immediate infusion reactions when compared with the previous IVIg preparation (Intragam P), there was no increase in the rate of reactions post infusion...
February 23, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/22212346/pharmacokinetics-and-safety-of-intragam-10-nf-the-next-generation-10-liquid-intravenous-immunoglobulin-in-patients-with-primary-antibody-deficiencies
#2
MULTICENTER STUDY
K Bleasel, R Heddle, P Hissaria, R Stirling, C Stone, D Maher
BACKGROUND AND AIMS: Intragam® 10 NF is the next generation 10% intravenous immunoglobulin with three pathogen reduction steps and a noncarbohydrate stabiliser. This open label, cross-over study in patients with primary immunodeficiency was designed to evaluate whether Intragam 10 NF differed in its pharmacokinetics (PK) compared with Intragam P and to assess Intragam 10 NF safety and tolerability. METHODS: Nineteen primary immunodeficiency patients were administered one cycle of their existing Intragam P dose (0...
March 2012: Internal Medicine Journal
https://www.readbyqxmd.com/read/19544484/evaluation-of-the-effect-of-intravenous-volume-expanders-upon-the-volume-of-distribution-of-gentamicin-in-septic-neonates
#3
Catherine M T Sherwin, Esther Kostan, Roland S Broadbent, Natalie J Medlicott, David M Reith
Sepsis has been reported to increase the volume of distribution of gentamicin in neonates. To determine whether this was caused by the use of intravenous volume expanders a retrospective nested case-control study was performed comparing confirmed septic neonates with non-septic controls. Data were collected on intravenous administration of 0.45% saline/10% dextrose, 0.45% saline/5% dextrose, 0.9% normal saline, red blood cells, platelets, immunoglobulin (Intragam P) and albumin. A population pharmacokinetic analysis was performed using NONMEM for 116 neonates (29 confirmed septic) from which 363 gentamicin serum concentrations were available...
July 2009: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/15030521/increased-risk-of-adverse-events-when-changing-intravenous-immunoglobulin-preparations
#4
R Ameratunga, J Sinclair, J Kolbe
Intravenous immunoglobulin (IVIG) therapy has represented a major advance in the treatment of patients with primary immune deficiency disorders. In September 2000 a new IVIG formulation, Intragam P, was introduced into clinical use. Intragam P is prepared by delipidation of pooled plasma followed by an ion exchange chromatography step to eliminate immunoglobulin aggregates. It is then pasteurized for 10 h at 60 degrees C for viral inactivation before storage at pH 4.25 in 10% maltose. We report initial clinical experience with this new preparation...
April 2004: Clinical and Experimental Immunology
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