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https://www.readbyqxmd.com/read/29224943/outcomes-after-early-and-delayed-carotid-endarterectomy-in-patients-with-symptomatic-carotid-artery-stenosis
#1
Ying Huang, Peter Gloviczki, Audra A Duncan, Manju Kalra, Gustavo S Oderich, Randall R DeMartino, William S Harmsen, Thomas C Bower
OBJECTIVE: The objective of this study was to define outcomes after carotid endarterectomy (CEA) in patients with symptomatic carotid artery stenosis (CAS) when patients are operated on within 14 days after onset of symptoms. METHODS: Clinical data of consecutive patients who underwent CEA between 2003 and 2012 for symptomatic CAS were reviewed. Patients were classified into group 1, CEA ≤14 days of minor stroke or transient ischemic attack, and group 2, CEA >14 days...
December 7, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29222905/premorbid-dietary-intake-of-protein-is-associated-with-early-outcomes-but-not-with-severity-of-ischemic-stroke
#2
Minhui Dai, Ling Tian, Wenjie Zi, Biyang Cai, Lulu Xiao, Keting Liu, Shuyu Zhou, Zhizhong Zhang, Wusheng Zhu, Fang Yang, Xinfeng Liu, Gelin Xu
BACKGROUND AND OBJECTIVES: Dietary protein intake has been associated with reduced risk of stroke. This study aimed to examine the relationship between premorbid dietary intake of protein and both stroke severity and neurological outcomes in patients with acute ischemic stroke. METHODS AND STUDY DESIGN: Consecutive patients with first-ever ischemic stroke in Jinling Hospital were screened for eligibility of participation. A validated foodfrequency questionnaire (FFQ) was performed to collect necessary data for calculating pre-stroke dietary intakes...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29215510/timing-and-risk-factors-of-postpartum-stroke
#3
Gloria Too, Timothy Wen, Amelia K Boehme, Eliza C Miller, Lisa R Leffert, Frank J Attenello, William J Mack, Mary E DʼAlton, Alexander M Friedman
OBJECTIVE: To characterize risk and timing of postpartum stroke readmission after delivery hospitalization discharge. METHODS: The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk of readmission for stroke within 60 days of discharge from a delivery hospitalization. Risk was characterized as odds ratios (ORs) with 95% CIs based on whether patients had hypertensive diseases of pregnancy (gestational hypertension or preeclampsia), or chronic hypertension, or neither disorder during the index hospitalization...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29212462/pharmacological-targeting-of-secondary-brain-damage-following-ischemic-or-hemorrhagic-stroke-traumatic-brain-injury-and-bacterial-meningitis-a-systematic-review-and-meta-analysis
#4
Thomas Beez, Hans-Jakob Steiger, Nima Etminan
BACKGROUND: The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic brain injury (TBI) and bacterial meningitis is unclear. This meta-analysis studied the effect of SBD targeted treatment on clinical outcome across the pathological entities. METHODS: Randomized, controlled, double-blinded trials on aforementioned entities with 'death' as endpoint were identified...
December 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29207983/protocol-for-project-impact-improving-millions-hearts-for-provider-and-community-transformation-a-quasi-experimental-evaluation-of-an-integrated-electronic-health-record-and-community-health-worker-intervention-study-to-improve-hypertension-management-among
#5
Priscilla M Lopez, Jennifer Zanowiak, Keith Goldfeld, Katarzyna Wyka, Ahmad Masoud, Susan Beane, Rashi Kumar, Phoebe Laughlin, Chau Trinh-Shevrin, Lorna Thorpe, Nadia Islam
BACKGROUND: The Million Hearts® initiative aims to prevent heart disease and stroke in the United States by mobilizing public and private sectors around a core set of objectives, with particular attention on improving blood pressure control. South Asians in particular have disproportionately high rates of hypertension and face numerous cultural, linguistic, and social barriers to accessing healthcare. Interventions utilizing Health information technology (HIT) and community health worker (CHW)-led patient coaching have each been demonstrated to be effective at advancing Million Hearts® goals, yet few studies have investigated the potential impact of integrating these strategies into a clinical-community linkage initiative...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29207365/thirty-day-outcomes-in-100-consecutive-patients-undergoing-transfemoral-aortic-valve-replacement-with-the-portico-valve-on-an-all-comer-basis
#6
Silvia Mas-Peiro, Mariuca Vasa-Nicotera, Helge Weiler, Nestoras Papadopoulos, Roberta De Rosa, Andreas M Zeiher, Stephan Fichtlscherer
OBJECTIVES: Transcatheter heart valves such as the self-expandable Portico valve (St. Jude Medical) are being developed to overcome limitations of first-generation devices. Since clinical experience with this valve is still limited in a real-world setting, we investigated its use on an all-comer basis. METHODS: Between October 2015 and October 2016, a total of 100 consecutive patients assessed for transcatheter aortic valve replacement (TAVR) and found suitable for the Portico valve were included...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29203690/autonomic-dysfunction-predicts-clinical-outcomes-after-acute-ischemic-stroke-a-prospective-observational-study
#7
Li Xiong, Ge Tian, Howan Leung, Yannie O Y Soo, Xiangyan Chen, Vincent H L Ip, Vincent C T Mok, Winnie C W Chu, Ka Sing Wong, Thomas W H Leung
BACKGROUND AND PURPOSE: Central autonomic dysfunction increases stroke morbidity and mortality. We aimed to investigate whether poststroke autonomic dysfunction graded by Ewing battery can predict clinical outcome. METHODS: In this prospective observational study, we assessed autonomic function of ischemic stroke patients within 7 days from symptom onset by Ewing battery. On the basis of the magnitude of autonomic dysfunction, we stratified patients into significant (definite, severe, or atypical) or minor (normal or early) autonomic function impairment groups and correlated the impairment with the 3-month modified Rankin Scale score (good outcome: modified Rankin Scale score 0≈2; poor outcome: modified Rankin Scale score 3≈6)...
December 4, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29198936/reaching-low-density-lipoprotein-cholesterol-treatment-targets-in-stable-coronary-artery-disease-determinants-and-prognostic-impact
#8
Christophe Bauters, Olivier Tricot, Gilles Lemesle, Thibaud Meurice, Olivier Hennebert, Michel Farnier, Nicolas Lamblin
BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) reduction is an integral part of the management of patients with coronary artery disease (CAD). AIMS: To assess attainment of LDL-C goals during long-term treatment of patients with stable CAD, and to determine predictors of goal attainment and the prognostic impact of reaching LDL-C<70mg/dL (1.8mmol/L) in a real-life setting. METHODS: Data were obtained for 4080 outpatients with stable CAD included in the multicentre CORONOR study...
November 30, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29191852/challenge-and-yield-of-enrolling-racially-and-ethnically-diverse-patient-populations-in-low-event-rate-clinical-trials
#9
Alice J Sheffet, George Howard, Albert Sam, Zafar Jamil, Fred Weaver, David Chiu, Jenifer H Voeks, Virginia J Howard, Susan E Hughes, Linda Flaxman, Mary E Longbottom, Thomas G Brott
BACKGROUND AND PURPOSE: We report patient enrollment and retention by race and ethnicity in the CREST (Carotid Revascularization Endarterectomy versus Stent Trial) and assess potential effect modification by race/ethnicity. In addition, we discuss the challenge of detecting differences in study outcomes when subgroups are small and the event rate is low. METHODS: We compared 2502 patients by race, ethnicity, baseline characteristics, and primary outcome (any periprocedural stroke, death, or myocardial infarction and subsequent ipsilateral stroke up to 10 years)...
November 30, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29188384/long-term-effects-of-complications-and-vascular-comorbidity-in-idiopathic-normal-pressure-hydrocephalus-a-quality-registry-study
#10
Kerstin Andrén, Carsten Wikkelsö, Nina Sundström, Simon Agerskov, Hanna Israelsson, Katarina Laurell, Per Hellström, Mats Tullberg
BACKGROUND: There is little knowledge about the factors influencing the long-term outcome after surgery for idiopathic normal pressure hydrocephalus (iNPH). OBJECTIVE: To evaluate the effects of reoperation due to complications and of vascular comorbidity (hypertension, diabetes, stroke and heart disease) on the outcome in iNPH patients, 2-6 years after shunt surgery. METHODS: We included 979 patients from the Swedish Hydrocephalus Quality Registry (SHQR), operated on for iNPH during 2004-2011...
November 29, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29174232/endovascular-mechanical-thrombectomy-in-large-vessel-occlusion-ischemic-stroke-presenting-with-low-nihss-a-systematic-review-and-meta-analysis
#11
REVIEW
Christoph J Griessenauer, Caroline Medin, Julian Maingard, Ronil V Chandra, Wyatt Ng, Duncan Mark Brooks, Hamed Asadi, Monika Killer-Oberpfalzer, Clemens M Schirmer, Justin M Moore, Christopher S Ogilvy, Ajith J Thomas, Kevin Phan
INTRODUCTION: Mechanical thrombectomy has become the standard of care for management of most large vessel occlusion (LVO) strokes. When patients with LVO present with minor stroke symptomatology, no consensus on the role of mechanical thrombectomy exists. METHODS: A systematic review and meta-analysis was performed to identify studies that focused on mechanical thrombectomy, either as a standalone treatment or with intravenous tissue plasminogen activator (IV tPA), in patients with mild strokes with LVO, defined as a baseline National Institutes of Health Stroke Scale (NIHSS) score ≤5 at presentation...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29172008/effects-of-cerebrolysin-on-nerve-growth-factor-system-in-the-aging-rat-brain
#12
Mikhail Stepanichev, Mikhail Onufriev, Viktor Aniol, Sofia Freiman, Hemma Brandstaetter, Stefan Winter, Natalia Lazareva, Alla Guekht, Natalia Gulyaeva
BACKGROUND: Aging is associated with some cognitive decline and enhanced risk of development of neurodegenerative diseases. It is assumed that altered metabolism and functions of neurotrophin systems may underlie these age-related functional and structural modifications. CerebrolysinTM (CBL) is a neuropeptide mixture with neurotrophic effects, which is widely used for the treatment of stroke and traumatic brain injury patients. It is also evident that CBL has an overall beneficial effect and a favorable benefit-risk ratio in patients with dementia...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29171136/prevalence-and-prognostic-impact-of-electrocardiographic-abnormalities-in-outpatients-with-extracardiac-artery-disease
#13
Per Hysing, Tommy Jonason, Jerzy Leppert, Pär Hedberg
Identifying cardiac disease in patients with extracardiac artery disease (ECAD) is essential for clinical decision-making. Electrocardiography (ECG) is an easily accessible tool to unmask subclinical cardiac disease and to risk stratify patient with or without manifest cardiovascular disease (CV). We aimed to examine the prevalence and prognostic impact of ECG changes in outpatients with ECAD. Outpatients with carotid or lower extremity artery disease (n = 435) and community-based controls (n = 397) underwent resting ECG...
November 24, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29169331/prescription-of-secondary-preventive-drugs-after-ischemic-stroke-results-from-the-malaysian-national-stroke-registry
#14
Wen Yea Hwong, Zariah Abdul Aziz, Norsima Nazifah Sidek, Michiel L Bots, Sharmini Selvarajah, L Jaap Kappelle, Sheamini Sivasampu, Ilonca Vaartjes
BACKGROUND: Evaluation of secondary stroke prevention in low and middle-income countries remains limited. This study assessed the prescription of secondary preventive drugs among ischemic stroke patients upon hospital discharge in Malaysia and identified factors related to the prescribing decisions. METHODS: From Malaysian National Stroke Registry, we included patients with non-fatal ischemic stroke. Prescriptions of antiplatelet, anticoagulants, antihypertensive drugs and lipid-lowering drugs were assessed...
November 23, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29141571/extra-virgin-olive-oil-and-cardiovascular-diseases-benefits-for-human-health
#15
Cristina Nocella, Vittoria Cammisotto, Luca Fianchini, Alessandra D'Amico, Marta Novo, Valentina Castellani, Lucia Stefanini, Francesco Violi, Roberto Carnevale
BACKGROUND AND OBJECTIVE: The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out the close relationship between the Mediterranean diet and cardiovascular diseases. In this context, extra virgin olive oil (EVOO), the most representative component of this diet, seems to be relevant in lowering the incidence of cardiovascular events, including myocardial infarction and stroke...
November 14, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29138181/one-year-outcome-of-intensive-insulin-therapy-combined-to-glucose-insulin-potassium-in-acute-coronary-syndrome-a-randomized-controlled-study
#16
Wahid Bouida, Kaouthar Beltaief, Mohamed Amine Msolli, Nasri Bzeouich, Adel Sekma, Malek Echeikh, Malek Mzali, Hamdi Boubaker, Mohamed Habib Grissa, Riadh Boukef, Mohsen Hassine, Zohra Dridi, Asma Belguith, Fadhel Najjar, Ines Khochtali, Semir Nouira
BACKGROUND: A number of factors may offset the cardioprotective effects of glucose-insulin-potassium (GIK) on outcome of patients with acute coronary syndrome, such as hyperglycemia induced by this cocktail infusion. We performed a study to evaluate the effect of intensive insulin therapy in association with GIK on 1-year outcome in patients hospitalized for acute coronary syndrome. METHODS AND RESULTS: In a randomized prospective controlled trial we included 772 patients with non-ST-segment elevation acute coronary syndrome...
November 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29133611/author-response-risks-and-benefits-of-clopidogrel-aspirin-in-minor-stroke-or-tia-time-course-analysis-of-chance
#17
Yuesong Pan, Yilong Wang, Yongjun Wang
No abstract text is available yet for this article.
November 14, 2017: Neurology
https://www.readbyqxmd.com/read/29133610/letter-re-risks-and-benefits-of-clopidogrel-aspirin-in-minor-stroke-or-tia-time-course-analysis-of-chance
#18
Jose Gutierrez, Tim Lekic
No abstract text is available yet for this article.
November 14, 2017: Neurology
https://www.readbyqxmd.com/read/29126415/cost-of-illness-of-atrial-fibrillation-a-nationwide-study-of-societal-impact
#19
Søren Paaske Johnsen, Lene Worsaae Dalby, Tomas Täckström, Jens Olsen, Anina Fraschke
BACKGROUND: The prevalence of atrial fibrillation is increasing rapidly; however, to date, population-based data are lacking on the attributable cost of illness of atrial fibrillation from a societal perspective, including both direct and indirect costs. METHODS: The study was an incidence-based cost-of-illness study based on national registries covering the entire population of Denmark. We identified all patients with a first-time hospital diagnosis of atrial fibrillation between 2001 and 2012...
November 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29122931/outcome-of-left-atrial-appendage-occlusion-in-high-risk-patients
#20
Ahmed Masoud, Stefano Bartoletti, Timothy Fairbairn, Ayush Khurana, Periaswamy Velavan, William Lindsay Morrison, Afshin Khalatbari, Suneil Aggarwal, Nikhill Sharma, Paulus Kirchhof, Dhiraj Gupta
OBJECTIVE: Percutaneous left atrial appendage (LAA) occlusion can be an interventional alternative to oral anticoagulation for stroke prevention in patients with atrial fibrillation. METHODS: We delivered LAA occlusion therapy using a standardised approach to patient referral, multidisciplinary team assessment, implant criteria, imaging and follow-up. We analysed patient characteristics, efficacy and safety of the implant procedure, and 12-month outcomes. RESULTS: Of 143 referrals from October 2014 to December 2016, 83 patients (age 76±8 years, 32...
November 9, 2017: Heart: Official Journal of the British Cardiac Society
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