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Metaanalysis seizure

Anis Chaari, Alaa Sayed Mohamed, Karim Abdelhakim, Vipin Kauts, William Francis Casey
Background The onset of early and/or late seizures in brain injured patients is associated with worse outcome. So far, phenytoin is the most commonly used antiepileptic drug to prevent seizures in this group of patients. Objective In the current metaanalysis, we aimed to compare the efficacy and safety of phenytoin versus levetiracetam for seizure prophylaxis in brain injured patients. Methods A systematic search was conducted in PubMed and Cochrane Library Database by 2 investigators. Four randomized controlled trials (RCTs) were included (295 patients)...
October 2017: International Journal of Clinical Pharmacy
Paul A Muller, Alvaro Pascual-Leone, Alexander Rotenberg
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is emerging as a valuable therapeutic and diagnostic tool. rTMS appears particularly promising for disorders characterized by positive sensory phenomena that are attributable to alterations in sensory cortical excitability. Among these are tinnitus, auditory and visual hallucinations, and pain syndromes. OBJECTIVE: Despite studies addressing rTMS efficacy in suppression of positive sensory symptoms, the safety of stimulation of potentially hyperexcitable cortex has not been fully addressed...
July 2012: Brain Stimulation
T Svendsen, S I Johannessen, K O Nakken
BACKGROUND: Topiramate is a novel antiepileptic drug that was licensed in Norway in 1997 as adjunctive treatment for patients with partial seizures. Metaanalysis of randomized controlled studies suggest that topiramate may be the most potent of the new antiepileptic drugs and have a favourable pharmacokinetic profile. At the National Center for Epilepsy we have used topiramate since 1990. We present our clinical experience with the drug. MATERIAL AND METHODS: We have, retrospectively, assessed 114 adult patients, mainly with intractable partial seizures, who received topiramate as add-on treatment...
May 20, 2000: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
B Pohlmann-Eden, A Schreiner, A Mika
Actual epidemiological studies show a prevalence rate for active epilepsy in 0.5-1%, whereas single seizures occur in up to 5% of the general population. Assessment of the significance of first epileptic reaction requires precise definition and classification of the episode, a careful analysis of the entire context including thorough case history, and indirect anamnesis. The value of EEG-techniques for this issue is part of a controversial discussion. By means of cranial computerized tomography (cCT), brain tumours were detected as structural correlate in 5 to 16% of first-seizure-patients...
May 1994: Fortschritte der Neurologie-Psychiatrie
A T Berg, S Shinnar, W A Hauser, J M Leventhal
The 1980 National Institutes of Health Consensus Development Conference on Febrile Seizures identified five circumstances in which it might be appropriate to consider anticonvulsant prophylaxis after a first febrile seizure: (1) a focal or prolonged seizure, (2) neurologic abnormalities, (3) afebrile seizures in a first-degree relative, (4) age less than 1 year, and (5) multiple seizures occurring within 24 hours. We performed a metaanalysis of 14 published reports to evaluate the strength of association between each of these indications and recurrent febrile seizures...
March 1990: Journal of Pediatrics
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