Adam R Denton, Srimal A Samaranayake, Kristin N Kirchner, Robert F Roscoe, Shane N Berger, Steven B Harrod, Charles F Mactutus, Parastoo Hashemi, Rosemarie M Booze
Between 30 and 60% of HIV-seropositive individuals develop symptoms of clinical depression and/or apathy. Dopamine and serotonin are associated with motivational alterations; however, histamine is less well studied. In the present study, we used fast-scan cyclic voltammetry in HIV-1 transgenic (Tg) rats to simultaneously analyze the kinetics of nucleus accumbens dopamine (DA), prefrontal cortical serotonin (5-HT), and hypothalamic histamine (HA). For voltammetry, subjects were 15 HIV-1 Tg (7 male, 8 female) and 20 F344/N (11 male, 9 female) adult rats...
May 17, 2019: Journal of Neurovirology