keyword
https://read.qxmd.com/read/37619819/longitudinal-dynamics-of-the-gut-microbiome-and-metabolome-in-peanut-allergy-development
#1
JOURNAL ARTICLE
Yoojin Chun, Alexander Grishin, Rebecca Rose, William Zhao, Zoe Arditi, Lingdi Zhang, Robert A Wood, A Wesley Burks, Stacie M Jones, Donald Y M Leung, Drew R Jones, Hugh A Sampson, Scott H Sicherer, Supinda Bunyavanich
BACKGROUND: Rising rates of peanut allergy motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk. OBJECTIVE: To gain insight into gut microbiome and metabolome dynamics in the development of peanut allergy. METHODS: We performed a longitudinal, integrative study of the gut microbiome and metabolome of infants with allergy risk factors but no peanut allergy from a multi-center cohort who were followed through mid-childhood...
August 22, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37273279/the-persistence-of-stress-induced-physical-inactivity-in-rats-an-investigation-of-central-monoamine-neurotransmitters-and-skeletal-muscle-oxidative-stress
#2
JOURNAL ARTICLE
Trevor J Buhr, Carter H Reed, Olivia M Wee, Ji Heun Lee, Li-Lian Yuan, Monika Fleshner, Rudy J Valentine, Peter J Clark
INTRODUCTION: Sedentary lifestyles have reached epidemic proportions world-wide. A growing body of literature suggests that exposures to adverse experiences (e.g., psychological traumas) are a significant risk factor for the development of physically inactive lifestyles. However, the biological mechanisms linking prior stress exposure and persistent deficits in physical activity engagement remains poorly understood. METHODS: The purpose of this study was twofold...
2023: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/37206665/snap25-differentially-contributes-to-g-i-o-coupled-receptor-function-at-glutamatergic-synapses-in-the-nucleus-accumbens
#3
JOURNAL ARTICLE
Kevin M Manz, José C Zepeda, Zack Zurawski, Heidi E Hamm, Brad A Grueter
The nucleus accumbens (NAc) guides reward-related motivated behavior implicated in pathological behavioral states, including addiction and depression. These behaviors depend on the precise neuromodulatory actions of Gi/o -coupled G-protein-coupled receptors (GPCRs) at glutamatergic synapses onto medium spiny projection neurons (MSNs). Previous work has shown that discrete classes of Gi/o -coupled GPCR mobilize Gβγ to inhibit vesicular neurotransmitter release via t-SNARE protein, SNAP25. However, it remains unknown which Gαi/o systems in the NAc utilize Gβγ-SNARE signaling to dampen glutamatergic transmission...
2023: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/36903922/uplc-esi-ms-ms-profiling-and-cytotoxic-antioxidant-anti-inflammatory-antidiabetic-and-antiobesity-activities-of-the-non-polar-fractions-of-salvia-hispanica-l-aerial-parts
#4
JOURNAL ARTICLE
Afaf E Abdel Ghani, Muneera S M Al-Saleem, Wael M Abdel-Mageed, Ehsan M AbouZeid, Marwa Y Mahmoud, Rehab H Abdallah
Salvia hispanica L. is an annual herbaceous plant commonly known as "Chia". It has been recommended for therapeutic use because of its use as an excellent source of fatty acids, protein, dietary fibers, antioxidants, and omega-3 fatty acids. A literature survey concerning phytochemical and biological investigations of chia extracts revealed less attention towards the non-polar extracts of S. hispanica L. aerial parts, which motivates us to investigate their phytochemical constituents and biological potentials...
February 27, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/36427690/acute-restraint-stress-impairs-histamine-type-2-receptor-ability-to-increase-the-excitability-of-medium-spiny-neurons-in-the-nucleus-accumbens
#5
JOURNAL ARTICLE
Giuseppe Aceto, Luca Nardella, Giacomo Lazzarino, Barbara Tavazzi, Alessia Bertozzi, Simona Nanni, Claudia Colussi, Marcello D'Ascenzo, Claudio Grassi
Histamine, a monoamine implicated in stress-related arousal states, is synthesized in neurons exclusively located in the hypothalamic tuberomammillary nucleus (TMN) from where they diffusely innervate striatal and mesolimbic networks including the nucleus accumbens (NAc), a vital node in the limbic loop. Since histamine-containing TMN neuron output increases during stress, we hypothesized that exposure of mice to acute restrain stress (ARS) recruits endogenous histamine type 2 receptor (H2R) signaling in the NAc, whose activation increases medium spiny neurons (MSNs) intrinsic excitability via downregulation of A-type K+ currents...
November 23, 2022: Neurobiology of Disease
https://read.qxmd.com/read/35704272/therapeutic-potential-of-histamine-h3-receptors-in-substance-use-disorders
#6
JOURNAL ARTICLE
Patricia Di Ciano, Christian S Hendershot, Bernard Le Foll
Substance use disorders are a leading cause of morbidity and mortality, and available pharmacological treatments are of modest efficacy. Histamine is a biogenic amine with four types of receptors. The histamine H3 receptor (H3 R) is an autoreceptor and also an heteroreceptor. H3 Rs are highly expressed in the basal ganglia, hippocampus and cortex, and regulate a number of neurotransmitters including acetylcholine, norepinephrine, GABA and dopamine. Its function and localization suggest that the H3 R may be relevant to a number of psychiatric disorders and could represent a potential therapeutic target for substance use disorders...
June 16, 2022: Current Topics in Behavioral Neurosciences
https://read.qxmd.com/read/35470562/acute-nicotine-treatment-enhances-compulsive-like-remifentanil-self-administration-that-persists-despite-contextual-punishment
#7
JOURNAL ARTICLE
Sarah C Honeycutt, Morgan S Paladino, Rece D Camadine, Ashmita Mukherjee, Gregory C Loney
Opioid use disorder (OUD) and opioid-related deaths remain a significant public health crisis having reached epidemic status globally. OUDs are defined as chronic, relapsing conditions often characterized by compulsive drug seeking despite the deleterious consequences of drug taking. The use of nicotine-containing products has been linked to increased likelihood of prescription opioid misuse, and there exists a significant comorbidity between habitual nicotine use and opioid dependence. In rodent models, nicotine administration nearly doubles the amount of opioids taken in intravenous self-administration paradigms...
May 2022: Addiction Biology
https://read.qxmd.com/read/35343587/activation-of-histamine-type-2-receptors-enhances-intrinsic-excitability-of-medium-spiny-neurons-in-the-nucleus-accumbens
#8
JOURNAL ARTICLE
Giuseppe Aceto, Luca Nardella, Simona Nanni, Valeria Pecci, Alessia Bertozzi, Claudia Colussi, Marcello D'Ascenzo, Claudio Grassi
Histaminergic neurons are exclusively located in the hypothalamic tuberomammillary nucleus, from where they project to many brain areas including the nucleus accumbens (NAc), a brain area that integrates diverse monoaminergic inputs to coordinate motivated behaviours. While the NAc expresses various histamine receptor subtypes, the mechanisms by which histamine modulates NAc activity are still poorly understood. Using whole-cell patch-clamp recordings, we found that pharmacological activation of histamine 2 (H2) receptors elevates the excitability of NAc medium spiny neurons (MSNs), while activation of H1 receptors failed to significantly affect MSN excitability...
May 2022: Journal of Physiology
https://read.qxmd.com/read/35339189/synthesis-strategies-and-medicinal-value-of-pyrrole-and-its-fused-heterocyclic-compounds
#9
JOURNAL ARTICLE
Samar Said Fatahala, Mosaad Sayed Mohamed, Jaqueline Youssef Sabry, Yara Esam El-Deen Mansour
For several decades, interest in pyrrole and pyrrolopyrimidine derivatives increases owing to their biological importance, such as anti-tumor, anti-microbial, anti-inflammatory, anti-diabetic, anti-histaminic, anti-malarial, anti-Parkinson, antioxidant and anti-viral, specially recently against COVID-19. These tremendous biological features motivated scientists to discover more pyrrole and fused pyrrole derivatives, owing to the great importance of the pyrrole nucleus as a pharmacophore in many drugs, and motivated us to present this article, highlighting on the different synthetic pathways of pyrrole and its fused compounds specially pyrrolopyrimidine, as well as their medicinal value from 2017 till 2021...
March 25, 2022: Medicinal Chemistry
https://read.qxmd.com/read/35327362/pathophysiological-studies-of-monoaminergic-neurotransmission-systems-in-valproic-acid-induced-model-of-autism-spectrum-disorder
#10
REVIEW
Hsiao-Ying Kuo, Fu-Chin Liu
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology. The core syndromes of ASD are deficits in social communication and self-restricted interests and repetitive behaviors. Social communication relies on the proper integration of sensory and motor functions, which is tightly interwoven with the limbic function of reward, motivation, and emotion in the brain. Monoamine neurotransmitters, including serotonin, dopamine, and norepinephrine, are key players in the modulation of neuronal activity...
February 27, 2022: Biomedicines
https://read.qxmd.com/read/34622397/targeting-histamine-and-histamine-receptors-for-the-precise-regulation-of-feeding
#11
JOURNAL ARTICLE
Yanrong Zheng, Zhong Chen
Histamine has long been accepted as an anorexigenic agent. However, lines of evidence have suggested that the roles of histamine in feeding behaviors are much more complex than previously thought, being involved in satiety, satiation, feeding motivation, feeding circadian rhythm, and taste perception and memory. The functional diversity of histamine makes it a viable target for clinical management of obesity and other feeding-related disorders. Here, we update the current knowledge about the functions of histamine in feeding and summarize the underlying molecular and neural circuit mechanisms...
October 8, 2021: Current Topics in Behavioral Neurosciences
https://read.qxmd.com/read/33907871/females-develop-features-of-an-addiction-like-phenotype-sooner-during-withdrawal-than-males
#12
JOURNAL ARTICLE
Eleanor Blair Towers, Anousheh Bakhti-Suroosh, Wendy J Lynch
RATIONALE: Women meet criteria for substance use disorder after fewer years of drug use than men; this accelerated time course, or telescoping effect, has been observed for multiple drugs, including cocaine. Preclinical findings similarly indicate an enhanced vulnerability in females to developing an addiction-like phenotype; however, it is not yet known if this phenotype develops faster in females versus males. OBJECTIVES: The goal of this study was to determine using a rat model whether two key features of addiction in humans, an enhanced motivation for cocaine and compulsive use, emerge sooner during withdrawal from extended access cocaine self-administration in females versus males...
April 27, 2021: Psychopharmacology
https://read.qxmd.com/read/33153760/misuse-and-dependence-of-dimenhydrinate-a-mixed-studies-systematic-review
#13
JOURNAL ARTICLE
Anees Bahji, Emily Kasurak, Morgan Sterling, Louise Good
BACKGROUND: Dimenhydrinate (DMH) is an antihistamine used to treat nausea and vomiting. Although widely available in pharmacies as an over the counter medication, there have been reports of potential DMH tolerance and dependence and a possible euphoric potential accompanying heavy use (>100 mg/day). Despite the potential for misuse, there is a gap in the literature concerning patterns, characteristics, and potential mechanisms of DMH misuse. AIMS: This review aimed to synthesize evidence on the pharmacology, clinical effects, and management of DMH misuse and dependence to inform clinical decision making and relevant drug policy...
April 2021: Journal of Psychiatric Research
https://read.qxmd.com/read/33012522/histamine-h-3-receptor-function-biases-excitatory-gain-in-the-nucleus-accumbens
#14
JOURNAL ARTICLE
Kevin M Manz, Jennifer C Becker, Carrie A Grueter, Brad A Grueter
BACKGROUND: Histamine (HA), a wake-promoting monoamine implicated in stress-related arousal states, is synthesized in histidine decarboxylase-expressing hypothalamic neurons of the tuberomammillary nucleus. Histidine decarboxylase-containing varicosities diffusely innervate striatal and mesolimbic networks, including the nucleus accumbens (NAc). The NAc integrates diverse monoaminergic inputs to coordinate motivated behavior. While the NAc expresses various HA receptor subtypes, mechanisms by which HA modulates NAc circuit dynamics are undefined...
August 6, 2020: Biological Psychiatry
https://read.qxmd.com/read/32833040/efficacy-and-safety-of-gastrointestinal-bleeding-prophylaxis-in-critically-ill-patients-an-updated-systematic-review-and-network-meta-analysis-of-randomized-trials
#15
JOURNAL ARTICLE
Ying Wang, Long Ge, Zhikang Ye, Reed A Siemieniuk, Annika Reintam Blaser, Xin Wang, Anders Perner, Morten H Møller, Waleed Alhazzani, Deborah Cook, Gordon H Guyatt
PURPOSE: Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients. METHODS: We searched for randomized controlled trials that examined the efficacy and safety of gastrointestinal bleeding prophylaxis with PPIs, H2RAs, or sucralfate versus one another or placebo or no prophylaxis in adult critically ill patients...
November 2020: Intensive Care Medicine
https://read.qxmd.com/read/32761576/metabolism-of-amino-acids-in-the-brain-and-their-roles-in-regulating-food-intake
#16
REVIEW
Wenliang He, Guoyao Wu
Amino acids (AAs) and their metabolites play an important role in neurological health and function. They are not only the building blocks of protein but are also neurotransmitters. In the brain, glutamate and aspartate are the major excitatory neurotransmitters, whereas γ-aminobutyrate (GABA, a metabolite of glutamate) and glycine are the major inhibitory neurotransmitters. Nitric oxide (NO, a metabolite of arginine), H2 S (a metabolite of cysteine), serotonin (a metabolite of tryptophan) and histamine (a metabolite of histidine), as well as dopamine and norepinephrine (metabolites of tyrosine) are neurotransmitters to modulate synaptic plasticity, neuronal activity, learning, motor control, motivational behavior, emotion, and executive function...
2020: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/32531750/identification-of-annotated-bioactive-molecules-that-impair-motility-of-the-blood-fluke-schistosoma-mansoni
#17
JOURNAL ARTICLE
Thomas B Duguet, Anastasia Glebov, Asimah Hussain, Shashank Kulkarni, Igor Mochalkin, Timothy G Geary, Mohammed Rashid, Thomas Spangenberg, Paula Ribeiro
Neglected tropical diseases are of growing worldwide concern and schistosomiasis, caused by parasitic flatworms, continues to be a major threat with more than 200 million people requiring preventive treatment. As praziquantel (PZQ) remains the treatment of choice, an urgent need for alternative treatments motivates research to identify new lead compounds that would complement PZQ by filling the therapeutic gaps associated with this treatment. Because impairing parasite neurotransmission remains a core strategy for control of parasitic helminths, we screened a library of 708 compounds with validated biological activity in humans on the blood fluke Schistosoma mansoni, measuring their effect on the motility on schistosomulae and adult worms...
June 1, 2020: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/31897573/clozapine-reliably-increases-the-motivation-for-food-parsing-the-role-of-the-5-ht-2c-and-h-1-receptors
#18
JOURNAL ARTICLE
Andrew R Abela, Xiao Dong Ji, Zhaoxia Li, Anh D Lê, Paul J Fletcher
RATIONALE AND OBJECTIVES: Although clozapine is effective in treating schizophrenia, it is associated with adverse side effects including weight gain and metabolic syndrome. Despite this, the role of clozapine on feeding behaviour and food intake has not been thoroughly characterised. Clozapine has a broad pharmacological profile, with affinities for several neurotransmitter receptors, including serotonin (5-hydroxytriptamine, 5-HT) and histamine. Given that the serotonin 5-HT2C receptor and histaminergic H1 receptor are involved in aspects of feeding behaviour, the effect of clozapine on feeding may be linked to its action at these receptors...
April 2020: Psychopharmacology
https://read.qxmd.com/read/31573374/quetiapine-abuse-fourteen-years-later-where-are-we-now-a-systematic-review
#19
JOURNAL ARTICLE
Alessandro E Vento, Georgios D Kotzalidis, Marta Cacciotti, G Duccio Papanti, Laura Orsolini, Chiara Rapinesi, Valeria Savoja, Giuseppa Calabrò, Antonio Del Casale, Daria Piacentino, Matteo Caloro, Paolo Girardi, Fabrizio Schifano
Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine antagonist, potent 5-HT2A -blocking, partial 5-HT1A -agonist, anti-H1 histamine, adrenolytic, and sigma1 receptor agonist activities, since an original 2004 report is increasingly misused. Although some of its pharmacodynamics might explain some motives for voluptuary use, most of its actions are directed at setting-off those motives. Hence, it is possible that its popularity in special populations is due to the fact that the unpleasant or unwanted effects of addiction substances are somehow soothed by quetiapine...
2020: Substance Use & Misuse
https://read.qxmd.com/read/31316329/effort-displayed-during-appetitive-phase-of-feeding-behavior-requires-infralimbic-cortex-activity-and-histamine-h1-receptor-signaling
#20
JOURNAL ARTICLE
María E Riveros, María Ines Forray, Fernando Torrealba, José L Valdés
The chances to succeed in goal-directed behaviors, such as food or water-seeking, improve when the subject is in an increased arousal state. The appetitive phase of these motivated behaviors is characterized by high levels of behavioral and vegetative excitation. The key decision of engaging in those particular behaviors depends primarily on prefrontal cortical areas, such as the ventromedial prefrontal cortex. We propose that the infralimbic cortex (ILC) located in the medial prefrontal cortex induces an increase in arousal during the appetitive phase of motivated behavior, and that this increase in arousal is, in turn, mediated by the activation of the brain histaminergic system, resulting in higher motivation for getting food rewards...
2019: Frontiers in Neuroscience
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