Alessandro E Vento, Georgios D Kotzalidis, Marta Cacciotti, G Duccio Papanti, Laura Orsolini, Chiara Rapinesi, Valeria Savoja, Giuseppa Calabrò, Antonio Del Casale, Daria Piacentino, Matteo Caloro, Paolo Girardi, Fabrizio Schifano
Background: Quetiapine, an atypical antipsychotic endowed with weak dopamine antagonist, potent 5-HT2A -blocking, partial 5-HT1A -agonist, anti-H1 histamine, adrenolytic, and sigma1 receptor agonist activities, since an original 2004 report is increasingly misused. Although some of its pharmacodynamics might explain some motives for voluptuary use, most of its actions are directed at setting-off those motives. Hence, it is possible that its popularity in special populations is due to the fact that the unpleasant or unwanted effects of addiction substances are somehow soothed by quetiapine...
2020: Substance Use & Misuse