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Arthur Saniotis, Maciej Henneberg, Abdul-Rahman Sawalma
Recent neuroscientific research demonstrates that the human brain is becoming altered by technological devices. Improvements in biotechnologies and computer based technologies are now increasing the likelihood for the development of brain augmentation devices in the next 20 years. We have developed the idea of an "Endomyccorhizae like interface" (ELI) nanocognitive device as a new kind of future neuroprosthetic which aims to facilitate neuronal network properties in individuals with neurodegenerative disorders...
2018: Frontiers in Neuroscience
Jing Zheng, Baohu Dai, Jizhuang Wang, Ze Xiong, Ya Yang, Jun Liu, Xiaojun Zhan, Zhihan Wan, Jinyao Tang
Nano/microswimmers represent the persistent endeavors of generations of scientists towards the ultimate tiny machinery for device manufacturing, targeted drug delivery, and noninvasive surgery. In many of these envisioned applications, multiple microswimmers need to be controlled independently and work cooperatively to perform a complex task. However, this multiple channel actuation remains a challenge as the controlling signal, usually a magnetic or electric field, is applied globally over all microswimmers, which makes it difficult to decouple the responses of multiple microswimmers...
November 10, 2017: Nature Communications
Zhi Shan, Mingsheng Lu, Dennis E Curry, Stefanie Beale, Stephen Campbell, Kristin M Poduska, Craig Bennett, Ken D Oakes, Xu Zhang
A highly regenerative multifunctional nanobot system, using Fe3 O4 @SiO2 @MgFe-LDH nanoparticles, is developed for efficient removal of waterborne azo dyes and pharmaceuticals. Efficient capture of pollutants, powerful Fenton degradation, and superior materials regeneration lead to a simple and cost-effective wastewater remediation solution.
September 25, 2017: Chemical Communications: Chem Comm
Philipp S Schattling, Miguel A Ramos-Docampo, Verónica Salgueiriño, Brigitte Städler
Self-propelled particles attract a great deal of attention due to the auspicious range of applications for which nanobots can be used. In a biomedical context, self-propelled swimmers hold promise to autonomously navigate to a desired location in an attempt to counteract cell/tissue defects either by releasing drugs or by performing surgical tasks. The vast majority of prior reports deal with single engine assemblies, often utilizing fuel molecules which are considered to be highly cytotoxic. Herein, we introduce two engines: (1) a motor which couples enzymes (i...
April 25, 2017: ACS Nano
Sabina Halappanavar, Ulla Vogel, Hakan Wallin, Carole L Yauk
In the 1966s visionary film 'Fantastic Voyage' a submarine crew was shrunk to 100 nm in size and injected into the body of an injured scientist to repair his damaged brain. The movie (written by Harry Kleiner; directed by Richard Fleischer; novel by Isaac Asimov) drew attention to the potential power of engineered nanoscale structures and devices to construct, monitor, control, treat, and repair individual cells. Even more interesting was the fact that the film elegantly noted that the structure had to be miniaturized to a size that is not detected by the body's immune surveillance system, and highlighted the many physiological barriers that are encountered on the submarine's long journey to the target...
January 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Jyotshna, Karuna Shanker, Puja Khare, Nimisha Tiwari, Shilpa Mohanty, Dnyaneshwar U Bawankule, Anirban Pal
Metals reduction into submicro/nano size through bhasma preparations for therapeutic use is well established in ancient traditional system of Indian medicines i.e. Ayurveda. Recently, nanotechnology has drawn the attention of researchers to develeope various size and shape nanoparicles / composite for number of applications.In this article, we report the enrichment of lactone enriched fraction (LEF) by liquid-liquid portioning of Vernonia cinerea metabolic extract and sysnthesis of mediated nano-gold composite (LEF-AuNPs) in single step process...
2016: Current Topics in Medicinal Chemistry
S Saxena, B J Pramod, B C Dayananda, K Nagaraju
Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dream of every oncologist.Nanorobots (or nanobots) are typical devices ranging in size from 0.1 to 10 μm and constructed of nanoscale or molecular components. Robots will augment the surgeon's motor performance, diagnostic capability and sensations with haptics and augmented reality...
April 2015: Indian Journal of Cancer
Asier Unciti-Broceta
No abstract text is available yet for this article.
July 2015: Nature Chemistry
Vinita Yadav, Wentao Duan, Peter J Butler, Ayusman Sen
Nature supports multifaceted forms of life. Despite the variety and complexity of these forms, motility remains the epicenter of life. The applicable laws of physics change upon going from macroscales to microscales and nanoscales, which are characterized by low Reynolds number (Re). We discuss motion at low Re in natural and synthetic systems, along with various propulsion mechanisms, including electrophoresis, electrolyte diffusiophoresis, and nonelectrolyte diffusiophoresis. We also describe the newly uncovered phenomena of motility in non-ATP-driven self-powered enzymes and the directional movement of these enzymes in response to substrate gradients...
2015: Annual Review of Biophysics
Luiz E da Silva
No abstract text is available yet for this article.
2015: Recent Patents on Anti-infective Drug Discovery
Eliézer Jäger, Fernando C Giacomelli
The current review aims to outline the likely medical applications of nanotechnology and the potential of the emerging field of nanomedicine. Nanomedicine can be defined as the investigation area encompassing the design of diagnostics and therapeutics at the nanoscale, including nanobots, nanobiosensors, nanoparticles and other nanodevices, for the remediation, prevention and diagnosis of a variety of illnesses. The ultimate goal of nanomedicine is to improve patient quality-of-life. Because nanomedicine includes the rational design of an enormous number of nanotechnology-based products focused on miscellaneous diseases, a variety of nanomaterials can be employed...
2015: Current Topics in Medicinal Chemistry
S C Takatori, W Yan, J F Brady
We discover a new contribution to the pressure (or stress) exerted by a suspension of self-propelled bodies. Through their self-motion, all active matter systems generate a unique swim pressure that is entirely athermal in origin. The origin of the swim pressure is based upon the notion that an active body would swim away in space unless confined by boundaries-this confinement pressure is precisely the swim pressure. Here we give the micromechanical basis for the swim stress and use this new perspective to study self-assembly and phase separation in active soft matter...
July 11, 2014: Physical Review Letters
Nima Sharifi-Mood, Joel Koplik, Charles Maldarelli
Chemical-mechanical transduction mechanisms which can actuate the movement of colloids through liquids are highly sought after as engines to propel miniaturized micro- and nanobots. One mechanism involves harnessing the long-range van der Waals attractive forces between the colloid and solute molecules dissolved in the liquid around the particle. If a concentration gradient of this solute is applied across the particle, then the imbalance in the van der Waals attraction drives the particle towards the higher concentration of solute...
November 1, 2013: Physical Review Letters
Chris Toumey
No abstract text is available yet for this article.
July 2013: Nature Nanotechnology
Manasmita Das, Raman Preet Singh, Satyajit R Datir, Sanyog Jain
The present study explores the possibility of exploiting surface functionality as one of the key regulators for modulating the intracellular trafficking and therapeutic performance of drug loaded carbon nanotubes (CNTs). In line with that approach, a series of biofunctionalized multiwalled carbon nanotubes (f-CNTs 1-6) decorated with various functional molecules including antifouling polymer (PEG), tumor recognition modules (folic acid/hyaluronic acid/estradiol), and fluorophores (rhodamine B isothiocyanate/Alexa Fluor) were synthesized...
April 17, 2013: Bioconjugate Chemistry
Bruce Rodenborn, Chih-Hung Chen, Harry L Swinney, Bin Liu, H P Zhang
The swimming of a bacterium or a biomimetic nanobot driven by a rotating helical flagellum is often interpreted using the resistive force theory developed by Gray and Hancock and by Lighthill, but this theory has not been tested for a range of physically relevant parameters. We test resistive force theory in experiments on macroscopic swimmers in a fluid that is highly viscous so the Reynolds number is small compared to unity, just as for swimming microorganisms. The measurements are made for the range of helical wavelengths λ, radii R, and lengths L relevant to bacterial flagella...
January 29, 2013: Proceedings of the National Academy of Sciences of the United States of America
Samudra Sengupta, Michael E Ibele, Ayusman Sen
The use of swarms of nanobots to perform seemingly miraculous tasks is a common trope in the annals of science fiction.1 Although several of these remarkable feats are still very much in the realm of fiction, scientists have recently overcome many of the physical challenges associated with operating on the small scale and have generated the first generation of autonomous self-powered nanomotors and pumps. The motors can be directed by chemical and light gradients, pick up and deliver cargo, and exhibit collective behavior...
August 20, 2012: Angewandte Chemie
David Klibansky, Richard I Rothstein
PURPOSE OF REVIEW: The increasing complexity of intralumenal and emerging translumenal endoscopic procedures has created an opportunity to apply robotics in endoscopy. Computer-assisted or direct-drive robotic technology allows the triangulation of flexible tools through telemanipulation. The creation of new flexible operative platforms, along with other emerging technology such as nanobots and steerable capsules, can be transformational for endoscopic procedures. In this review, we cover some background information on the use of robotics in surgery and endoscopy, and review the emerging literature on platforms, capsules, and mini-robotic units...
September 2012: Current Opinion in Gastroenterology
Ayaz Mahmood Khawaja
Nanotechnology has been an ever-growing field since the discovery of carbon fullerenes, and is being assimilated progressively into a variety of other disciplines including medical science. The association with neurosurgery had initially been less well characterized compared to other organ systems, but has recently offered promising future potential for a wide range of utilities including new therapeutic options for Glioblastoma Multiforme, neurprotection against oxidative stress, nerve nanorepair, nanodiagnosis of Alzheimer's disease, nanoimaging with nanoparticles and quantum dots, nanomanipulation of CNS with surgical nanobots, and nanoneuromodulation with nanofibres & nanowires...
2011: International Journal of Surgery
T Jacob, K Hemavathy, J Jacob, A Hingorani, N Marks, E Ascher
AIM: We previously demonstrated that adenovirus-mediated p53 gene transfer following balloon angioplasty, decreased neointimal hyperplasia. However, safety concerns arise because viral promoters can cause unrestricted transgene expression. The paucity of safe and efficient vehicles for gene transfer thus limits the potential for clinical utilization of gene therapy. Our objective was to design and clone a virus-free p53 construct, targeted to express specifically in vascular smooth muscle cells (SMCs), via a nanoparticle-based delivery system for therapeutic modulation in vascular wall...
April 2011: Journal of Cardiovascular Surgery
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