keyword
MENU ▼
Read by QxMD icon Read
search

Plga

keyword
https://www.readbyqxmd.com/read/29143781/biological-properties-of-low-toxic-plga-and-plga-phb-fibrous-nanocomposite-scaffolds-for-osseous-tissue-regeneration-evaluation-of-potential-bioactivity
#1
Boguslawa Żywicka, Izabella Krucińska, Jerzy Garcarek, Maria Szymonowicz, Agnieszka Komisarczyk, Zbigniew Rybak
Abstracts: The aim of the study was to evaluate the biocompatibility and bioactivity of two new prototype implants for bone tissue regeneration made from biodegradable fibrous materials. The first is a newly developed poly(l-lactide-co-glycolide), (PLGA), and the second is a blend of PLGA with synthetic poly([R,S]-3-hydroxybutyrate) (PLGA/PHB). The implant prototypes comprise PLGA or PLGA/PHB nonwoven fabrics with designed pore structures to create the best conditions for cell proliferation. The bioactivity of the proposed implants was enhanced by introducing a hydroxyapatite material and a biologically active agent, namely, growth factor IGF1, encapsulated in calcium alginate microspheres...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29143524/injectable-shear-thinning-caso4-fgf-18-incorporated-chitin-plga-hydrogels-enhances-bone-regeneration-in-mice-cranial-bone-defect-model
#2
Sivashanmugam Amirthalingam, Pornkawee Charoenlarp, Sankar Deepthi, ArunKumar Rajendran, Shantikumar V Nair, Sachiko Iseki, Rangasamy Jayakumar
For craniofacial bone regeneration, shear thinning injectable hydrogels are favoured over conventional scaffolds due to their improved defect margin adaptability, easier handling and ability to be injected manually into deeper tissues. The most accepted method, after autografting, is the use of recombinant human BMP-2; however, complications such as inter-individual variations, edema, and poor cost-efficiency in supraphysiological doses have been reported. The endogenous synthesis of BMP-2 is desirable, and a molecule which induces this is FGF-18 since it can up-regulate the BMP-2 expression and positively modulate other osteogenic genes...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29133206/relationship-between-polarities-of-antibiotic-and-polymer-matrix-on-nanoparticle-formulations-based-on-aliphatic-polyesters
#3
J A S Ritsema, E M A Herschberg, S E Borgos, C Løvmo, R Schmid, Y M Te Welscher, G Storm, C F van Nostrum
In the field of nanomedicine, nanoparticles are developed to target antibiotics to sites of bacterial infection thus enabling adequate drug exposure and decrease development of resistant bacteria. In the present study, we investigated the encapsulation of two antibiotics with different polarity into different PEGylated polymeric nanoparticles based on aliphatic polyesters, to obtain a better understanding of critical factors determining encapsulation and release. The nanoparticles were prepared from diblock copolymers comprising of a poly(ethylene glycol) block attached to an aliphatic polyester block of varying polarity: poly(lactic-co-glycolic acid) (mPEG-PLGA), poly(lactic-co-hydroxymethyl glycolic acid) (mPEG-PLHMGA) and poly(lactic-co-benzyloxymethyl glycolic acid) (mPEG-PLBMGA)...
November 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29131564/light-emitting-photon-upconversion-nanoparticles-in-the-generation-of-transdermal-reactive-oxygen-species
#4
Martin Prieto, Alina Rwei, Teresa Alejo, Wei Tuo, Maria Teresa Lopez-Franco, Gracia Mendoza, Victor Sebastian, Daniel S Kohane, Manuel Arruebo
Common photosensitizers used in photodynamic therapy do not penetrate the skin effectively. In addition, the visible blue and red lights used to excite such photosensitizers have shallow penetration depths through tissue. To overcome these limitations, we have synthesized ultraviolet and visible light emitting, energy-transfer based upconversion nanoparticles, and co-encapsulated them inside PLGA-PEG nanoparticles with photosensitizer protoporphyrin IX. Nd3+ has been introduced as sensitizer in the upconversion nanostructures to allow their excitation at 808 nm...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29131563/sustained-codelivery-of-cisplatin-and-paclitaxel-via-an-injectable-prodrug-hydrogel-for-ovarian-cancer-treatment
#5
Wenjia Shen, Xiaobin Chen, Jiabin Luan, Danni Wang, Lin Yu, Jiandong Ding
The sustained release of both the hydrophilic drug and hydrophobic drug from one delivery system remains challenging in pharmaceutics and biomaterials science. The combination of hydrophilic cisplatin and hydrophobic paclitaxel (PTX) exhibits a clinical survival advantage compared with the individual drug therapy against various tumors such as ovarian cancer. In this study, a localized, long-term codelivery system of cisplatin and PTX was developed using an injectable and thermosensitive polymer-platinum(IV) conjugate hydrogel as the carrier...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29130392/a-novel-hybrid-multichannel-biphasic-calcium-phosphate-granule-based-composite-scaffold-for-cartilage-tissue-regeneration
#6
Albert Jung, Preeti Makkar, Jhaleh Amirian, Byong-Taek Lee
The objective of the present study was to develop a novel hybrid multichannel biphasic calcium phosphate granule (MCG)-based composite system for cartilage regeneration. First, hyaluronic acid-gelatin (HG) hydrogel was coated onto MCG matrix (MCG-HG). Poly(lactic-co-glycolic acid) (PLGA) microspheres was separately prepared and modified with polydopamine subsequent to BMP-7 loading (B). The surface-modified microspheres were finally embedded into MCG-HG scaffold to develop the novel hybrid (MCG-HG-PLGA-PD-B) composite system...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29130038/nanomedicine-for-inner-ear-diseases-a-review-of-recent-in-vivo-studies
#7
REVIEW
Dong-Kee Kim
Nanoparticles are promising therapeutic options for inner ear disease. In this report, we review in vivo animal studies in the otologic field using nanoparticles over the past 5 years. Many studies have used nanoparticles to deliver drugs, genes, and growth factors, and functional and morphological changes have been observed. The constituents of nanoparticles are also diversifying into various biocompatible materials, including poly(lactic-co-glycolic acid) (PLGA). The safe and effective delivery of drugs or genes in the inner ear will be a breakthrough for the treatment of inner ear diseases, including age-related hearing loss...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29129734/ciprofloxacin-loaded-sodium-alginate-poly-lactic-co-glycolic-acid-electrospun-fibrous-mats-for-wound-healing
#8
Xiaoli Liu, Line Hagner Nielsen, Sylvia Natalie Klodzinska, Hanne Mørck Nielsen, Haiyan Qu, Lars Porskjær Christensen, Jukka Rantanen, Mingshi Yang
Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles...
November 9, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29128846/tissue-adhesive-fk506-loaded-polymeric-nanoparticles-for-multi-layered-nano-shielding-of-pancreatic-islets-to-enhance-xenograft-survival-in-a-diabetic-mouse-model
#9
Tung Thanh Pham, Tiep Tien Nguyen, Shiva Pathak, Shobha Regmi, Hanh Thuy Nguyen, Tuan Hiep Tran, Chul Soon Yong, Jong Oh Kim, Pil-Hoon Park, Min Hui Park, Young Kyung Bae, Jeong Uk Choi, Youngro Byun, Cheol-Hee Ahn, Simmyung Yook, Jee-Heon Jeong
This study aims to develop a novel surface modification technology to prolong the survival time of pancreatic islets in a xenogenic transplantation model, using 3,4-dihydroxyphenethylamine (DOPA) conjugated poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) nanoparticles (DOPA-NPs) carrying immunosuppressant FK506 (FK506/DOPA-NPs). The functionalized DOPA-NPs formed a versatile coating layer for antigen camouflage without interfering the viability and functionality of islets. The coating layer effectively preserved the morphology and viability of islets in a co-culture condition with xenogenic lymphocytes for 7 days...
November 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/29128617/benign-preparation-of-aqueous-core-poly-lactic-co-glycolic-acid-plga-microcapsules
#10
Toshiyuki Nomura, Alexander F Routh
Poly lactic-co-glycolic acid (PLGA) has attracted considerable attention as a polymer for drug delivery carriers. However, the hydrophobic property of PLGA often leads to the use of harmful organic solvents and poor encapsulation efficiency of hydrophilic materials. To our knowledge, a preparation method of aqueous core PLGA microcapsules without using harmful organic solvents has not been proposed. In this study, we attempted to establish an encapsulation technique of hydrophilic materials in aqueous core biodegradable and biocompatible PLGA microcapsules using vegetable oil as a continuous phase...
November 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29126629/characterization-of-innate-responses-induced-by-in-ovo-administration-of-encapsulated-and-free-forms-of-ligands-of-toll-like-receptor-4-and-21-in-chicken-embryos
#11
Jegarubee Bavananthasivam, Tamiru N Alkie, Ayumi Matsuyama-Kato, Douglas C Hodgins, Shayan Sharif
Toll-like receptors (TLRs) are a family of innate receptors that recognize pathogen-associated molecular patterns, including double-stranded RNA, CpG DNA and lipopolysaccharide (LPS). After interaction with their ligands, TLRs initiate innate responses that are manifested by activating cells and inducing expression of cytokines that help mediate adaptive immune responses. TLR ligands (TLR-Ls) have the potential to be used prophylactically (alone) or as vaccine adjuvants to promote host immunity. Encapsulating TLR-Ls in nanoparticles, such as Poly (d,l-lactic-co-glycolic acid), may prolong responses through sustained release of the ligands...
October 25, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29122712/development-of-plga-nanoparticles-loaded-with-clofazimine-for-oral-delivery-assessment-of-formulation-variables-and-intestinal-permeability
#12
Luíse L Chaves, Sofia A Costa Lima, Alexandre C C Vieira, Luísa Barreiros, Marcela A Segundo, Domingos Ferreira, Bruno Sarmento, Salette Reis
The use of polymeric nanoparticles as delivery systems is a promising tool to overcome drawbacks related to low aqueous solubility of drugs, which limit their in vivo bioavailability. The aim of this study was to decrease clofazimine (CLZ) toxicity using experimental design to formulate CLZ loaded in PLGA nanoparticles (NPs-CLZ) through a Plackett-Burman design (PBD). A screening PBD was constructed with twelve formulations involving six variables among process and formulation parameters and the selected responses were particle size, polydispersity index (PDI), association efficiency (AE) and drug loading (DL)...
November 6, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29122407/three-dimensional-poly-lactic-co-glycolic-acid-scaffold-containing-autologous-platelet-rich-plasma-supports-keloid-fibroblast-growth-and-contributes-to-keloid-formation-in-a-nude-mouse-model
#13
Chunlin Chen, Haibin Wang, Guozhang Zhu, Zhongsheng Sun, Xiang Xu, Fangwei Li, Shengkang Luo
BACKGROUND: There is a lack of proper animal models to study keloid formation. AIM: To create three-dimensional poly lactic-co-glycolic acid (PLGA) scaffolds containing autologous platelet-rich plasma (PRP) as an in vitro culture environment for keloid fibroblasts (KL), and to study their implantation into nude mice to mimic the process of keloid formation. METHODS: Normal fibroblasts (FB) and KL cells were isolated from surgical specimens and transduced with lentivirus loaded with green fluorescent protein (GFP) and luciferase genes...
October 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29121571/high-throughput-%C3%AE-spe-based-elution-coupled-with-uplc-ms-ms-for-determination-of-eluxadoline-in-plasma-sample-application-in-pharmacokinetic-characterization-of-plga-nanoparticle-formulations-in-rats
#14
Muzaffar Iqbal, Essam Ezzeldin, Khalid A Al-Rashood, Ramadan Al-Shdefat, Md Khalid Anwer
Eluxadoline is a novel μ- and κ-opioid receptor (OR) agonist and δ-OR antagonist, recently approved as a first line therapy for the treatment of irritable bowel syndrome. Due to abuse potential, poor bioavailability and high intersubject variability, a sensitive and reliable assay is prerequisite for its determination in biological samples. This work first time report the development and validation of UPLC-MS/MS assay for determination of eluxadoline in rat plasma sample using risperidone as an internal standard (IS)...
October 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29119735/poly-d-l-lactic-co-glycolic-acid-based-artesunate-nanoparticles-formulation-antimalarial-and-toxicity-assessments
#15
Kabiru Dauda, Zulaikha Busari, Olajumoke Morenikeji, Funmilayo Afolayan, Oyetunde Oyeyemi, Jairam Meena, Debasis Sahu, Amulya Panda
OBJECTIVE: The aim of this study was to formulate polymer-based artesunate nanoparticles for malaria treatment. METHODS: Artesunate was loaded with poly(D,L-lactic-co-glycolic acid) (PLGA) by solvent evaporation from an oil-in-water single emulsion. Nanoparticles were characterized by X-ray diffraction and differential scanning calorimetry analyses. In vivo antimalarial studies at 4 mg/kg were performed on Swiss male albino mice infected with Plasmodium berghei...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29119734/tissue-engineered-composite-scaffold-of-poly-lactide-co-glycolide-and-hydroxyapatite-nanoparticles-seeded-with-autologous-mesenchymal-stem-cells-for-bone-regeneration
#16
Bing Zhang, Pei-Biao Zhang, Zong-Liang Wang, Zhong-Wen Lyu, Han Wu
OBJECTIVE: A new therapeutic strategy using nanocomposite scaffolds of grafted hydroxyapatite (g-HA)/ poly(lactide-co-glycolide) (PLGA) carried with autologous mesenchymal stem cells (MSCs) and bone morphogenetic protein-2 (BMP-2) was assessed for the therapy of critical bone defects. At the same time, tissue response and in vivo mineralization of tissue-engineered implants were investigated. METHODS: A composite scaffold of PLGA and g-HA was fabricated by the solvent casting and particulate-leaching method...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#17
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29116098/chemodrug-delivery-using-integrin-targeted-plga-chitosan-nanoparticle-for-lung-cancer-therapy
#18
Anish Babu, Narsireddy Amreddy, Ranganayaki Muralidharan, Gopal Pathuri, Hariprasad Gali, Allshine Chen, Yan D Zhao, Anupama Munshi, Rajagopal Ramesh
In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin αvβ3 receptor targeted paclitaxel (PTX) delivery in lung cancer cells and its impact on normal cells. RGD peptide-modified chitosan was synthesized and then coated onto PTX-PLGA nanoparticles prepared by emulsion-solvent evaporation. PTX-PLGA-CSNP-RGD displayed favorable physicochemical properties for a targeted drug delivery system...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113502/osteogenic-and-antibacterial-properties-of-vancomycin-laden-mesoporous-bioglass-plga-composite-scaffolds-for-bone-regeneration-in-infected-bone-defects
#19
Tao Cheng, Haiyun Qu, Guoyou Zhang, Xianlong Zhang
Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water contact angle analysis suggested that the MBG-incorporated PLGA scaffold exhibited controlled degradability, stabilizing the pH of the surrounding environment and improved the hydrophilicity...
November 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29113362/plga-nanoparticles-modified-with-a-bbb-penetrating-peptide-co-delivering-a%C3%AE-generation-inhibitor-and-curcumin-attenuate-memory-deficits-and-neuropathology-in-alzheimer-s-disease-mice
#20
Na Huang, Shuai Lu, Xiao-Ge Liu, Jie Zhu, Yu-Jiong Wang, Rui-Tian Liu
Alzheimer's disease (AD) is the most common form of dementia, characterized by the formation of extracellular senile plaques and neuronal loss caused by amyloid β (Aβ) aggregates in the brains of AD patients. Conventional strategies failed to treat AD in clinical trials, partly due to the poor solubility, low bioavailability and ineffectiveness of the tested drugs to cross the blood-brain barrier (BBB). Moreover, AD is a complex, multifactorial neurodegenerative disease; one-target strategies may be insufficient to prevent the processes of AD...
October 6, 2017: Oncotarget
keyword
keyword
56956
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"