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https://www.readbyqxmd.com/read/28921444/polyester-based-nanoparticles-for-delivery-of-therapeutic-proteins
#1
Pedro Fonte, Flávia Sousa, Bruno Sarmento
Therapeutic proteins are widely used to treat severe conditions, such as oncologic and metabolic diseases, and also for vaccination. They are recognized for its high biopotency, but their hydrophilicity and high molecular weight make its transport through membranes difficult to achieve. They may also suffer in vivo structural instability caused by a proteolytic cleavage, turning them biological inactive. Polyester-based nanoparticles are useful tools to overcome such problems, and deliver therapeutic proteins in a controlled and localized manner, decreasing the number of administrations needed and enhancing the therapeutic outcome...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28919710/irinotecan-and-5-fluorouracil-co-loaded-hyaluronic-acid-modified-layer-by-layer-nanoparticles-for-targeted-gastric-carcinoma-therapy
#2
Zhuanglei Gao, Zhaoxia Li, Jieke Yan, Peilin Wang
For targeted gastric carcinoma therapy, hyaluronic acid (HA)-modified layer-by-layer nanoparticles (NPs) are applied for improving anticancer treatment efficacy and reducing toxicity and side effects. The aim of this study was to develop HA-modified NPs for the co-loading of irinotecan (IRN) and 5-fluorouracil (5-FU). A novel polymer-chitosan (CH)-HA hybrid formulation (HA-CH-IRN/5-FU NPs) consisting of poly(d,l-lactide-co-glycolide) (PLGA) and IRN as the core, CH and 5-FU as a shell on the core and HA as the outmost layer was prepared...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28919045/cover-story-enhanced-intrapericardial-drug-delivery-by-plga-nanoparticles
#3
EDITORIAL
Kinam Park
No abstract text is available yet for this article.
September 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28917531/hollow-microneedle-mediated-intradermal-delivery-of-model-vaccine-antigen-loaded-plga-nanoparticles-elicits-protective-t-cell-mediated-immunity-to-an-intracellular-bacterium
#4
Anne Marit de Groot, Guangsheng Du, Juha Mönkäre, Anouk C M Platteel, Femke Broere, Joke A Bouwstra, Alice J A M Sijts
The skin is an attractive organ for immunization due to the presence of a large number of epidermal and dermal antigen-presenting cells. Hollow microneedles allow for precise and non-invasive intradermal delivery of vaccines. In this study, ovalbumin (OVA)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles with and without TLR3 agonist poly(I:C) were prepared and administered intradermally by hollow microneedles. The capacity of the PLGA nanoparticles to induce a cytotoxic T cell response, contributing to protection against intracellular pathogens, was examined...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28917119/a-mechanistic-model-for-drug-release-from-plga-based-drug-eluting-stent-a-computational-study
#5
Jahed Naghipoor, Timon Rabczuk
Atherosclerosis in the coronary artery is one of the leading causes of death in the world. The stenting as a minimally invasive technique was considered as an effective tool to reduce the severity of atherosclerotic stenosis. In-stent restenosis is the main drawback of the stenting in the coronary artery. Understanding the mechanism of drug release from drug-eluting stents and drug uptake in the arterial wall and obtaining more information about their functionality using mathematical modeling and numerical simulation, could be considered as a predictive tool to investigate in-stent restenosis growth which is experimentally expensive to study...
September 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28915522/comparison-of-platelet-rich-plasma-stromal-vascular-fraction-svf-or-svf-with-an-injectable-plga-nanofiber-scaffold-for-the-treatment-of-osteochondral-injury-in-dogs
#6
Samuel P Franklin, Aaron M Stoker, Chantelle C Bozynksi, Keiichi Kuroki, Kevin M Clarke, Jed K Johnson, James L Cook
No abstract text is available yet for this article.
September 15, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28914822/cytotoxic-evaluation-of-2s-5-7-dihydroxy-6-prenylflavanone-derivatives-loaded-plga-nanoparticles-against-miapaca-2-cells
#7
Berenice Andrade-Carrera, Beatriz Clares, Véronique Noé, Mireia Mallandrich, Ana C Calpena, María Luisa García, María Luisa Garduño-Ramírez
The search for new alternatives for the prevention and treatment of cancer is extremely important to minimize human mortality. Natural products are an alternative to chemical drugs, since they are a source of many potential compounds with anticancer properties. In the present study, the (2S)-5,7-dihydroxy-6-prenylflavanone (semi-systematic name), also called (2S)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-2-phenyl-2,3-dihydro-4H-1-Benzopyran-4-one (CAS Name registered) (1) was isolated from Eysenhardtia platycarpa leaves...
September 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28913707/endocytic-pathways-involved-in-plga-nanoparticle-uptake-by-grapevine-cells-and-role-of-cell-wall-and-membrane-in-size-selection
#8
Cleofe Palocci, Alessio Valletta, Laura Chronopoulou, Livia Donati, Marco Bramosanti, Elisa Brasili, Barbara Baldan, Gabriella Pasqua
PLGA NPs' cell uptake involves different endocytic pathways. Clathrin-independent endocytosis is the main internalization route. The cell wall plays a more prominent role than the plasma membrane in NPs' size selection. In the last years, many studies on absorption and cell uptake of nanoparticles by plants have been conducted, but the understanding of the internalization mechanisms is still largely unknown. In this study, polydispersed and monodispersed poly(lactic-co-glycolic) acid nanoparticles (PLGA NPs) were synthesized, and a strategy combining the use of transmission electron microscopy (TEM), confocal analysis, fluorescently labeled PLGA NPs, a probe for endocytic vesicles (FM4-64), and endocytosis inhibitors (i...
September 14, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28911246/dual-targeting-of-l-carnitine-conjugated-nanoparticles-to-octn2-and-atb-0-to-deliver-chemotherapeutic-agents-for-colon-cancer-therapy
#9
Longfa Kou, Qing Yao, Sathish Sivaprakasam, Qiuhua Luo, Yinghua Sun, Qiang Fu, Zhonggui He, Jin Sun, Vadivel Ganapathy
l-Carnitine, obligatory for oxidation of fatty acids, is transported into cells by the Na(+)-coupled transporter OCTN2 and the Na(+)/Cl(-)-coupled transporter ATB(0,+). Here we investigated the potential of L-carnitine-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (LC-PLGA NPs) to deliver chemotherapeutic drugs into cancer cells by targeting the nanoparticles to both OCTN2 and ATB(0,+). The cellular uptake of LC-PLGA NPs in the breast cancer cell line MCF7 and the colon cancer cell line Caco-2 was increased compared to unmodified nanoparticles, but decreased in the absence of co-transporting ions (Na(+) and/or Cl(-)) or in the presence of competitive substrates for the two transporters...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28903181/development-and-characterization-of-hyaluronic-acid-modified-plga-based-nanoparticles-for-improved-efficacy-of-cisplatin-in-solid-tumor
#10
Noor Alam, Mytre Koul, Mubashir J Mintoo, Vaibhav Khare, Rahul Gupta, Neha Rawat, Parduman Raj Sharma, Shashank K Singh, Dilip M Mondhe, Prem N Gupta
Cisplatin is a potent and widely used chemotherapeutic agent to treat a variety of tumors. However, its clinical use is associated with undesirable side effects and acquired resistance to cisplatin. In this study, cisplatin loaded hyaluronic acid (HA) functionalized poly (lactic-co-glycolic acid)-poly (ethylene glycol) nanoparticles (CP-HA-PLGA-PEG-NPs) were fabricated using double emulsion solvent evaporation method to target CD44 receptor expressed on cancerous cells. The developed nanoconstructs were characterized for various in vitro parameters, including size distribution, zeta potential, morphology, drug loading and in vitro release...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28902491/biodegradable-viral-nanoparticle-polymer-implants-prepared-via-melt-processing
#11
Parker W Lee, Sourabh Shukla, Jaqueline D Wallat, Chaitanya Danda, Nicole F Steinmetz, Joao Maia, Jonathan K Pokorski
Viral nanoparticles have been utilized as a platform for vaccine development and are a versatile system for the display of antigenic epitopes for a variety of disease states. However, the induction of a clinically relevant immune response often requires multiple injections over an extended period of time, limiting patient compliance. Polymeric systems to deliver proteinaceous materials have been extensively researched to provide sustained release, which would limit administration to a single dose. Melt-processing is an emerging manufacturing method that has been utilized to create polymeric materials laden with proteins as an alternative to typical solvent-based production methods...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28901139/an-injectable-and-self-healing-thermo-sensitive-magnetic-hydrogel-for-asynchronous-control-release-of-doxorubicin-and-docetaxel-to-treat-triple-negative-breast-cancer
#12
Wensheng Xie, Qin Gao, Zhenhu Guo, Dan Wang, Fei Gao, Xiu-Mei Wang, Yen Wei, Lingyun Zhao
Integration of two or more drugs in a multi-agent delivery system has been considered to have profound impacts on both in vitro and in vivo cancer treatment due to their efficient synergistic effect. This study presents a cheap and simple chitosan hydrogel crosslinked with telechelic difunctional poly (ethylene glycol) (DF-PEG-DF) for synthesis of an injectable and self-healing thermo-sensitive dual-drug-loaded magnetic hydrogel (DDMH), which contains both doxorubicin (DOX) and docetaxel (DTX) for chemotherapy, and iron oxide for magnetic hyperthermia induced stimuli responsive drug release...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28898763/absolute-quantification-of-poly-dl-lactide-co-glycolide-in-microspheres-using-quantitative-1-h-nmr-spectroscopy
#13
Qi Zhang, Ningzi Guo, Yue Sun, Xiaodong Li, Huaxin Yang
The complex nature and the manufacturing process of poly(dl-lactide-co-glycolide) (PLGA), a key component of PLGA-based microspheres, have made the quantification of this copolymer difficult. The main purpose of the current study was to investigate the potential of three different methods for the quantitative analysis of the PLGA content of clinical products. In this regard, leuprorelin acetate microspheres from different vendors were chosen as templates to validate quantitative (1)H nuclear magnetic resonance (qHNMR) spectroscopy, size exclusion chromatography (SEC), and high-performance liquid chromatography (HPLC) methods qHNMR proved to be an excellent and rapid PLGA quantification method compared to the other two...
September 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28895767/promising-galactose-decorated-biodegradable-poloxamer-188-plga-diblock-copolymer-nanoparticles-of-resibufogenin-for-enhancing-liver-cancer-therapy
#14
Hao Dong, Li Tian, Meng Gao, Hong Xu, Chenghong Zhang, Li Lv, Jianbin Zhang, Changyuan Wang, Yan Tian, Xiaochi Ma
Liver cancer is one of the major diseases affecting human health. Modified drug delivery systems through the asialoglycoprotein receptor, which is highly expressed on the surface of hepatocytes, have become a research focus for the treatment of liver cancer. Resibufogenin (RBG) is a popular traditional Chinese medicine and natural anti-cancer drug that was isolated from Chansu, but its cardiotoxicity and hydrophobicity have limited its clinical applications. Galactosyl-succinyl-poloxamer 188 and galactosyl-succinyl-poloxamer 188-polylactide-co-glycolide (Gal-SP188-PLGA) were synthesized using galactose, P188, and PLGA to achieve active liver-targeting properties...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28894228/ascorbic-acid-tethered-polymeric-nanoparticles-enable-efficient-brain-delivery-of-galantamine-an-in-vitro-in-vivo-study
#15
Kavita R Gajbhiye, Virendra Gajbhiye, Imtiaz A Siddiqui, Srikanth Pilla, Vandana Soni
The aim of this work was to enhance the transportation of the galantamine to the brain via ascorbic acid grafted PLGA-b-PEG nanoparticles (NPs) using SVCT2 transporters of choroid plexus. PLGA-b-PEG copolymer was synthesized and characterized by (1)H NMR, gel permeation chromatography, and differential scanning calorimetry. PLGA-b-PEG-NH2 and PLGA-b-mPEG NPs were prepared by nanoprecipitation method. PLGA-b-PEG NPs with desirable size, polydispersity, and drug loading were used for the conjugation with ascorbic acid (PLGA-b-PEG-Asc) to facilitate SVCT2 mediated transportation of the same into the brain...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892870/effects-of-terminal-capping-on-the-fibrillation-of-short-l-glu-n-peptides
#16
Agnieszka Hernik-Magoń, Bartłomiej Fedorczyk, Robert Dec, Wojciech Puławski, Aleksandra Misicka, Wojciech Dzwolak
Several homopolypeptides including poly-l-glutamic acid (PLGA) form amyloid-like fibrils under favorable physicochemical conditions. We have shown recently that even short uncapped (Glu)n peptides (for n>3) form fibrillar β-aggregates which cross-seed with amyloid fibrils obtained from high molecular weight fractions of PLGA. Here we investigate effects of N-terminal acetylation and C-terminal amidation on the amyloidogenic tendencies of (Glu)n peptides containing 3, 4, and 5 residues. Our results based primarily on time-lapse FT-IR spectroscopy and AFM microscopy indicate that selective modifications of C-termini (and, to a lesser degree, of N-termini) decrease capacity of tetra- and pentapeptides to form fibrils...
September 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28891231/development-and-characterization-of-electrosprayed-nanoparticles-for-encapsulation-of-curcumin
#17
Zahra Esmaili, Samaneh Bayrami, Farid Abedin Dorkoosh, Hamid Akbari Javar, Ehsan Seyedjafari, Seyed Shahrooz Zargarian, Vahid Haddadi-Asl
Curcumin has been proven to be an effective herbal derived anti-inflammatory and antioxidant biocompatible agent. In this research PLGA (as a biocompatible and GRAS polymer) nanoparticles containing Curcumin were electrospryed from different polymeric solutions with different concentrations for the first time. Morphology of these nanoparticles in the absence/presence of Curcumin was evaluated by SEM, TEM and XPS analyses. Perfectly shaped nanoparticles with an average size of 300 and 320 nanometers were observed for neat and Curcumin loaded PLGA, respectively...
September 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28888677/quantitation-of-lanosterol-in-the-vitreous-humor-of-rabbits-after-ocular-administration-of-lanosterol-thermogel-formulation-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-with-the-electrospray-ionization-mode
#18
Lei Lv, Dan Li, Hui Wang, Chengjian Li, Xian Qian, Heng-Tao Dong, Jianguo Sun, Liang Zhao
Cataracts are the most common cause of blindness worldwide affecting tens of millions of people. Here, we report a simple, rapid, sensitive and specific method by ultra performance liquid chromatography-tandem mass spectrometry with the electrospray ionization mode (UPLC-ESI-MS/MS) for quantitation of lanosterol, a possible effective drug for cataracts, in the vitreous humor of rabbits after ocular administration. The injected lanosterol was prepared by dispersing lanosterol molecules into the poly-(dl-lactic acid-co-glycolic acid)-poly(ethylene glycol)-poly-(dl-lactic acid-co-glycolic acid) (PLGA-PEG-PLGA) thermogel solution...
September 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28887134/decreased-non-specific-adhesivity-receptor-targeted-dart-nanoparticles-exhibit-improved-dispersion-cellular-uptake-and-tumor-retention-in-invasive-gliomas
#19
Aniket S Wadajkar, Jimena G Dancy, Nathan B Roberts, Nina P Connolly, Dudley K Strickland, Jeffrey A Winkles, Graeme F Woodworth, Anthony J Kim
The most common and deadly form of primary brain cancer, glioblastoma (GBM), is characterized by significant intratumoral heterogeneity, microvascular proliferation, immune system suppression, and brain tissue invasion. Delivering effective and sustained treatments to the invasive GBM cells intermixed with functioning neural elements is a major goal of advanced therapeutic systems for brain cancer. Previously, we investigated the nanoparticle characteristics that enable targeting of invasive GBM cells. This revealed the importance of minimizing non-specific binding within the relatively adhesive, 'sticky' microenvironment of the brain and brain tumors in particular...
September 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28886515/development-and-characterization-of-cores-shell-poly-lactide-co-glycolide-chitosan-microparticles-for-sustained-release-of-gdnf
#20
Wen Zeng, Zhongyang Liu, Yuqian Li, Shu Zhu, Jie Ma, Weixin Li, Guodong Gao
The microencapsulation of bioactive neurotrophic factors in biodegradable poly(lactide-co-glycolide) (PLGA) microspheres has been a promising tool in the treatment of various nervous system disorders. However, challenges still exist; the PLGA burst drug release and acidic degradation products often limit clinical application. In this study, cores-shell PLGA-chitosan microparticles (MPs) were fabricated with a single shell of chitosan and multi-cores of PLGA using a re-emulsification method. The glial cell line-derived neurotrophic factor (GDNF) was encapsulated at the PLGA cores of the cores-shell MPs...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
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