keyword
MENU ▼
Read by QxMD icon Read
search

Plga

keyword
https://www.readbyqxmd.com/read/29344306/131i-labeled-copper-sulfide-loaded-microspheres-to-treat-hepatic-tumors-via-hepatic-artery-embolization
#1
Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Jianjun Liu, Xiaoguang Sun, Michael Fulham, Dagan Feng, Gang Huang, Wei Lu, Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (131I) to produce 131I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29342838/biopolymer-based-nanoparticles-for-cystic-fibrosis-lung-gene-therapy-studies
#2
Elena Fernández Fernández, Beatriz Santos-Carballal, Chiara de Santi, Joanne M Ramsey, Ronan MacLoughlin, Sally-Ann Cryan, Catherine M Greene
Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells demands suitable non-viral systems. In this work, we describe the formulation and the physicochemical investigation of biocompatible and biodegradable polymeric nanoparticles (NPs), including PLGA and chitosan (animal and non-animal), as novel methods for the safe and efficient delivery of CFTR-specific locked nucleic acids (LNAs)...
January 13, 2018: Materials
https://www.readbyqxmd.com/read/29335533/fc-modified-exenatide-loaded-nanoparticles-for-oral-delivery-to-improve-hypoglycemic-effects-in-mice
#3
Yanan Shi, Xinfeng Sun, Liping Zhang, Kaoxiang Sun, Keke Li, Youxin Li, Qiang Zhang
To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery. Exenatide was encapsulated into the NPs by the w/o/w emulsion-solvent evaporation method. The particle size of the NPs-Fc was approximately 30 nm larger than that of the unmodified NPs with polydispersity indices in a narrow range (PDIs; PDI < 0.3) as detected by DLS, and the highest encapsulation efficiency of exenatide in the NPs was greater than 80%...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334805/delivery-of-radix-ophiopogonis-polysaccharide-via-sucrose-acetateisobutyrate-based-in-situ-forming-systems-alone-or-combined-with-itsmono-pegylation
#4
LiNa Wang, Xiao Zheng, Fei Wu, Lan Shen, Xiao Lin, Yi Feng
This work aimed to achieve long-lasting delivery of radix ophiopogonis polysaccharide (ROP) by sucrose acetate isobutyrate (SAIB)-based in situ forming systems (ISFSs) alone or combined with mono-PEGylation of ROP. When the '90%SAIB/10% solvent' system was used, the mean residence time (MRT) of ROP was prolonged by 4.3 5 ∼ 7.00 times and the initial release rate was reduced significantly. However, this system was only suitable for days-long sustained release of ROP in short-term therapy. As to the 'SAIB/additives/solvent' system containing mono-PEGylated ROP, the results indicated that SAIB/poly(d,l-lactide-co-glycolide) (PLGA)/N-methyl-2-pyrrolidone (NMP) was superior to SAIB/polylactic acid (PLA)/NMP and SAIB/PLA/ethanol in controlled release...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29334080/effects-of-microarchitecture-and-mechanical-properties-of-3d-microporous-plla-plga-scaffolds-on-fibrochondrocyte-and-l929-fibroblast-behavior
#5
Gokhan Bahcecioglu, Nesrin Hasırcı, Vasif Hasirci
There are several reports studying cell behavior on surfaces in 2D or in hydrogels in 3D. However, cell behavior in 3D microporous scaffolds has not been investigated extensively. In this study, poly(L-lactic acid)/poly(lactic acid-co-glycolic acid) (PLLA/PLGA)-based microporous scaffolds were used to study the effects of scaffold microarchitecture and mechanical properties on the behavior of two different cell types, human meniscal fibrochondrocytes and L929 mouse fibroblasts. In general, cell attachment, spreading and proliferation rate were mainly regulated by the strut stiffness...
January 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29331580/local-delivery-of-mometasone-furoate-from-an-eluting-endotracheal-tube
#6
Abu Ammar Aiman, Maayan Gruber, Patrick Martin, Ohad Stern, Forsan Jahshan, Offir Ertracht, Eyal Sela, Samer Srouji, Eyal Zussman
Laryngeal and tracheal morbidity is a common complication of endotracheal tube (ETT)-based airway management, and manifests as local irritation, inflammation, and edema. Systemic corticosteroids are commonly administered to manage these conditions; however, their efficacy is inadequate and limited by potential severe side effects. In the present study, a steroid delivery system for local therapy was developed to generate relatively high local drug concentrations and to improve drug efficacy. ETTs were coated with electrospun poly (lactic-co-glycolic acid) (PLGA) nanofibers loaded with mometasone furoate (MF), creating a microscale thick layer...
January 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29329648/preparation-and-physicochemical-characterization-of-t-oa-plga-microspheres
#7
Jing Fu, Xiao-Xu Dong, Zu-Ping Zeng, Xing-Bin Yin, Fa-Wei Li, Jian Ni
As the carrier of water-insoluble drugs, microspheres can play a role in increasing solubility and delaying releasing essence. The objective of this study was to improve the solubility and to delay the release of a newly discovered antitumor compound 3β-hydroxyolea-12-en-28-oic acid-3, 5, 6-trimethylpyrazin-2-methyl ester (T-OA). Early-stage preparation discovery concept (EPDC) was employed in the present study. The preparation, physicochemical characterization, and drug release properties of PLGA microspheres were evaluated...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329209/gentamicin-sulfate-peg-plga-plga-h-nanoparticles-screening-design-and-antimicrobial-effect-evaluation-toward-clinic-bacterial-isolates
#8
Rossella Dorati, Antonella DeTrizio, Melissa Spalla, Roberta Migliavacca, Laura Pagani, Silvia Pisani, Enrica Chiesa, Bice Conti, Tiziana Modena, Ida Genta
Nanotechnology is a promising approach both for restoring or enhancing activity of old and conventional antimicrobial agents and for treating intracellular infections by providing intracellular targeting and sustained release of drug inside infected cells. The present paper introduces a formulation study of gentamicin loaded biodegradable nanoparticles (Nps). Solid-oil-in water technique was studied for gentamicin sulfate nanoencapsulation using uncapped Polylactide-co-glycolide (PLGA-H) and Polylactide-co-glycolide-co-Polyethylenglycol (PLGA-PEG) blends...
January 12, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29329052/efficient-and-cost-effective-generation-of-hepatocyte-like-cells-through-microparticle-mediated-delivery-of-growth-factors-in-a-3d-culture-of-human-pluripotent-stem-cells
#9
Zeinab Heidariyan, Mohammad Hossein Ghanian, Mohsen Ashjari, Zahra Farzaneh, Mostafa Najarasl, Mehran Rezaei Larijani, Abbas Piryaei, Massoud Vosough, Hossein Baharvand
Biomedical application of human pluripotent stem cell-derived hepatocyte-like cells (hPSC-HLCs) relies on efficient large-scale differentiation, which is commonly performed by a suspension culture of three-dimensional (3D) multicellular spheroids in bioreactors. However, this approach requires large amounts of growth factors (GFs) and the need to overcome limited diffusional transport posed by the inherent 3D structure of hPSC spheroids. Here, we have hypothesized that localized delivery of GFs by incorporation of GF-laden degradable polymeric microparticles (MPs) within the hPSC spheroids would circumvent such limitations...
January 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29327779/locally-delivered-ethyl-2-5-dihydroxybenzoate-using-3d-printed-bone-implant-for-promotion-of-bone-regeneration-in-a-osteoporotic-animal-model
#10
B-J Kwon, G M Seon, M H Lee, M-A Koo, M S Kim, D Kim, J-J Han, D Kim, J Kim, J-C Park
Osteoporosis is a disease characterized by low bone mass, most commonly caused by an increase in bone resorption that is not matched by sufficient bone formation. The most common complications of postmenopausal osteoporosis are bone-related defects and fractures. Fracture healing is a multifactorial bone regeneration process, influenced by both biological and mechanical factors related to age, osteoporosis and stability of the osteosynthesis. During the treatment of bone defects in osteoporotic conditions, imbalanced bone remodeling is the leading cause for implant failure...
January 12, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29327399/plga-mpeg-nanoparticles-loaded-with-melatonin-protect-adipose-derived-stem-cells-transplanted-in-infarcted-heart-tissue
#11
Qiang Ma, Junjie Yang, Xu Huang, Weisheng Guo, Sulei Li, Hao Zhou, Jingwei Li, Yundai Chen
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. However, melatonin cannot play a long lasting effect against the hostile microenvironment. Nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects...
January 12, 2018: Stem Cells
https://www.readbyqxmd.com/read/29327198/graphene-oxide-hybridized-nhac-plga-scaffolds-facilitate-the-proliferation-of-mc3t3-e1-cells
#12
Chunyong Liang, Yongchao Luo, Guodong Yang, Dan Xia, Lei Liu, Xiaomin Zhang, Hongshui Wang
Biodegradable porous biomaterial scaffolds play a critical role in bone regeneration. In this study, the porous nano-hydroxyapatite/collagen/poly(lactic-co-glycolic acid)/graphene oxide (nHAC/PLGA/GO) composite scaffolds containing different amount of GO were fabricated by freeze-drying method. The results show that the synthesized scaffolds possess a three-dimensional porous structure. GO slightly improves the hydrophilicity of the scaffolds and reinforces their mechanical strength. Young's modulus of the 1...
January 11, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29325770/development-of-a-non-toxic-and-non-denaturing-formulation-process-for-encapsulation-of-sdf-1%C3%AE-into-plga-peg-plga-nanoparticles-to-achieve-sustained-release
#13
Muhammad Haji Mansor, Mathie Najberg, Aurélien Contini, Carmen Alvarez-Lorenzo, Emmanuel Garcion, Christine Jérôme, Frank Boury
No abstract text is available yet for this article.
January 8, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29324696/quantitative-assessment-of-antimicrobial-activity-of-plga-films-loaded-with-4-hexylresorcinol
#14
Michael Kemme, Regina Heinzel-Wieland
Profound screening and evaluation methods for biocide-releasing polymer films are crucial for predicting applicability and therapeutic outcome of these drug delivery systems. For this purpose, we developed an agar overlay assay embedding biopolymer composite films in a seeded microbial lawn. By combining this approach with model-dependent analysis for agar diffusion, antimicrobial potency of the entrapped drug can be calculated in terms of minimum inhibitory concentrations (MICs). Thus, the topical antiseptic 4-hexylresorcinol (4-HR) was incorporated into poly(lactic-co-glycolic acid) (PLGA) films at different loadings up to 3...
January 11, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29323913/nanoparticles-with-cd44-targeting-and-ros-triggering-property-as-effective-in-vivo-antigen-delivery-system
#15
Xiaoyu Liang, Xuanling Li, Jianwei Duan, Youlu Chen, Xiaoli Wang, Liyun Pang, Deling Kong, Bing Song, Chen Li, Jing Yang
Currently, development of subunit vaccine based on recombinant antigens or peptides has gradually become an important alternative option for traditional vaccine. However, induction of potent immune response with desired efficacy remains a major challenge. The nanoparticle-based antigen delivery system has been considered a potential carrier system to improve the efficacy of subunit vaccine. In the present study, we have designed an immune-stimulatory delivery system by conjugating three-armed PLGA to PEG via the peroxalate ester bond which is sensitive to hydrogen peroxide (H2O2), a major reactive oxygen species (ROS)...
January 11, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29321663/lpa-signaling-is-regulated-through-the-primary-cilium-a-novel-target-in-glioblastoma
#16
Yuriy V Loskutov, Caryn L Griffin, Kristina M Marinak, Andrey Bobko, Naira V Margaryan, Werner J Geldenhuys, Jann N Sarkaria, Elena N Pugacheva
The primary cilium is a ubiquitous organelle presented on most human cells. It is a crucial signaling hub for multiple pathways including growth factor and G-protein coupled receptors. Loss of primary cilia, observed in various cancers, has been shown to affect cell proliferation. Primary cilia formation is drastically decreased in glioblastoma (GBM), however, the role of cilia in normal astrocyte or glioblastoma proliferation has not been explored. Here, we report that loss of primary cilia in human astrocytes stimulates growth rate in a lysophosphatidic acid (LPA)-dependent manner...
January 11, 2018: Oncogene
https://www.readbyqxmd.com/read/29317820/enhanced-bone-regeneration-using-an-insulin-loaded-nano-hydroxyapatite-collagen-plga-composite-scaffold
#17
Xing Wang, Guilan Zhang, Feng Qi, Yongfeng Cheng, Xuguang Lu, Lu Wang, Jing Zhao, Bin Zhao
Insulin is widely considered as a classical hormone and drug in maintaining energy and glucose homeostasis. Recently, insulin has been increasingly recognized as an indispensable factor for osteogenesis and bone turnover, but its applications in bone regeneration have been restricted because of the short periods of activity and uncontrolled release. In this study, we incorporated insulin-loaded poly lactic-co-glycolic-acid (PLGA) nanospheres into nano-hydroxyapatite/collagen (nHAC) scaffolds and investigated the bioactivity of the composite scaffolds in vitro and in vivo...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29315978/the-efficacy-of-basic-fibroblast-growth-factor-loaded-poly-lactic-co-glycolic-acid-nanosheet-for-mouse-wound-healing
#18
Shimpo Aoki, Mao Fujii, Toshinori Fujie, Keisuke Nishiwaki, Hiromi Miyazaki, Daizoh Saitoh, Shinji Takeoka, Tomoharu Kiyosawa, Manabu Kinoshita
Although human recombinant basic fibroblast growth factor (bFGF) is widely used for wound healing, daily treatment with bFGF is required because of its short half-life. An effective controlled-release system of bFGF is therefore desired in clinical settings. To investigate the efficacy of a bFGF-loaded nanosheet for wound healing, focusing on the controlled-release of bFGF, bFGF-loaded poly lactic-co-glycolic acid (PGLA) nanosheets were developed, and their in vitro release profile of bFGF and their in vivo efficacy for wound healing were examined...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29314827/macrophage-specific-in-vivo-gene-editing-using-cationic-lipid-assisted-polymeric-nanoparticles
#19
Ying-Li Luo, Cong-Fei Xu, Hong-Jun Li, Zhi-Ting Cao, Jing Liu, Ji-Long Wang, Xiao-Jiao Du, Xian-Zhu Yang, Zhen Gu, Jun Wang
The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, the inability to perform specific gene editing in targeted tissues and cells, which may cause off-target effects, is one of the critical bottlenecks for therapeutic application of CRISPR/Cas9. Herein, macrophage-specific promoter-driven Cas9 expression plasmids (pM458 and pM330) were constructed and encapsulated in cationic lipid-assisted PEG-b-PLGA nanoparticles (CLAN). The obtained nanoparticles encapsulating the CRISPR/Cas9 plasmids were able to specifically express Cas9 in macrophages as well as their precursor monocytes both in vitro and in vivo...
January 9, 2018: ACS Nano
https://www.readbyqxmd.com/read/29313030/poly-2-propylacrylic-acid-poly-lactic-co-glycolic-acid-blend-microparticles-as-a-targeted-antigen-delivery-system-to-direct-either-cd4-or-cd8-t-cell-activation
#20
Lirong Yang, Evelyn Bracho-Sanchez, Lawrence P Fernando, Jamal S Lewis, Matthew R Carstens, Craig L Duvall, Benjamin G Keselowsky
Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner. Micron-sized PLGA MPs are readily phagocytosed by antigen presenting cells, and localized to endosomes. Due to low pH and digestive enzymes, encapsulated protein cargo is largely degraded and processed in endosomes for MHC-II loading and presentation to CD4+ T cells, with very little antigen delivered into the cytosol, limiting MHC-I antigenic loading and presentation to CD8+ T cells...
June 2017: Bioengineering & Translational Medicine
keyword
keyword
56956
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"