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https://www.readbyqxmd.com/read/29674965/development-of-matrix-metalloproteinase-2-inhibitors-for-cardioprotection
#1
Péter Bencsik, Krisztina Kupai, Anikó Görbe, Éva Kenyeres, Zoltán V Varga, János Pálóczi, Renáta Gáspár, László Kovács, Lutz Weber, Ferenc Takács, István Hajdú, Gabriella Fabó, Sándor Cseh, László Barna, Tamás Csont, Csaba Csonka, György Dormán, Péter Ferdinandy
The objective of our present study is to develop novel inhibitors for MMP-2 for acute cardioprotection. In a series of pilot studies, novel substituted carboxylic acid derivatives were synthesized based on imidazole and thiazole scaffolds and then tested in a screeening cascade for MMP inhibition. We found that the MMP-inhibiting effects of imidazole and thiazole carboxylic acid-based compounds are superior in efficacy in comparison to the conventional hydroxamic acid derivatives of the same molecules. Based on these results, a 568-membered focused library of imidazole and thiazole compounds was generated in silico and then the library members were docked to the 3D model of MMP-2 followed by an in vitro medium throughput screening (MTS) based on a fluorescent assay employing MMP-2 catalytic domain...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29672106/mmpi-2-rf-characteristics-of-veterans-seeking-treatment-for-military-sexual-trauma
#2
Eliza S McManus, Lisa-Ann J Cuccurullo, Madeline Uddo, C Laurel Franklin
Military sexual trauma (MST) is defined as experiences of sexual assault or repeated, threatening, harassment during military service. MST events may not qualify within posttraumatic stress disorder (PTSD) Criterion A, making symptoms associated with MST unique from trauma-related disorders. Little research has been done to understand those presenting for MST treatment. Thus, this article provides Minnesota Multiphasic Personality Inventory 2-Restructured Form (MMPI-2-RF) scores of 33 U.S. veterans who experienced MST in an effort to better understand psychological and personality characteristics of this important and unique group of veterans...
April 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29580567/association-of-depression-anxiety-and-post-traumatic-stress-disorder-with-migraine-data-from-kosovo
#3
Nexhmedin Shala, Shemsedin Dreshaj
INTRODUCTION: Migraine is ranked as the seventh leading cause of disability worldwide, and it is characterized by a manifestation of combined neurological, gastrointestinal, and autonomic symptoms linked with different provoking factors. AIM OF THE STUDY: This study investigates the association between migraine and PTSD, depression and anxiety in the Kosovo population during the post-war period. MATERIAL AND METHODS: 273 war survivors with headache were enrolled in the study and were divided into two groups: 153 individuals with confirmed migraine (the study group) and 120 individuals with non-migraine headaches (control group)...
March 15, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29548501/the-expert-and-the-foreigner-reflections-of-forensic-transcultural-psychopathology-on-a-total-of-86-reports-by-experts-on-criminal-liability
#4
Isabella Merzagora, Alberto Amadasi, Alberto Blandino, Guido Travaini
In recent times Italy has been experiencing massive migration flows, therefore the attention on the issue of crimes committed by foreigners is increasing. But within trials, in the evaluation of criminal liability of foreigners, how do experts deal with them? Do the performed evaluations take cultural diversity into account? The present study took origin from these questions and examined a total of 86 reports by experts on criminal liability of foreign persons (16 females and 70 males). Examinees have been declared indictable in 31 cases (36%), totally mentally ill in 40 cases (45%) and with diminished liability in 15 cases (17%); when liability was excluded, examinees were diagnosed in 11 cases with mood disorders, in 23 cases with personality disorders, in 4 cases with adaptation disorders and post-traumatic stress disorder and in 10 cases with different diagnoses (in some cases more than one diagnosis was present)...
March 2018: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29480047/-low-intensity-evidence-based-cognitive-behavioural-therapy-of-a-patient-with-crohn-s-disease
#5
Dóra Antal-Uram, László Harsányi, Dóra Perczel-Forintos
Inflammatory bowel disease (Crohn's disease and colitis ulcerosa) is a chronic, long-term condition that causes chronic inflammation in the digestive tract, and shows an increasing incidence and prevalence worldwide. Changes in disease activity over time affect psychological distress which increases the risk of exacerbations. Beside somatic symptoms (such as abdominal pain, diarrhoea and weight loss), psychiatric comorbidity (in particular major depression, anxiety, social phobia) is common in patients with Crohn's disease...
March 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29450796/prospective-comparison-of-the-minnesota-multiphasic-personality-inventory-2-mmpi-2-and-mmpi-2-restructured-form-mmpi-2-rf-in-predicting-treatment-outcomes-among-patients-with-chronic-low-back-pain
#6
Anthony M Tarescavage, Judith Scheman, Yossef S Ben-Porath
The purpose of the current study was to examine the relative utility of the most updated MMPI adult instrument, the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), which was designed to address psychometric limitations of the MMPI-2. To this end, we compared mean scores and correlates of emotional distress treatment outcomes using the Depression Anxiety Stress Scales in a sample of 230 patients (73 males, 157 females) who had completed an interdisciplinary chronic pain rehabilitation program...
February 15, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29424554/predicting-postprobationary-job-performance-of-police-officers-using-cpi-and-mmpi-2-rf-test-data-obtained-during-preemployment-psychological-screening
#7
Ryan M Roberts, Anthony M Tarescavage, Yossef S Ben-Porath, Michael D Roberts
We examined associations between prehire California Psychological Inventory (CPI) and prorated Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF) scores (calculated from MMPI profiles) and supervisor ratings for a sample of 143 male police officers. Substantive scale scores in this sample were meaningfully lower than those obtained by the tests' normative samples in the case of the MMPI-2-RF and meaningfully higher in the case of the CPI (indicating less psychological dysfunction). Test scores from both instruments showed substantial range restriction, consistent with those produced by members of the police candidate comparison groups (Corey & Ben-Porath, 2014 ; Roberts & Johnson, 2001 )...
February 9, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29400479/temperamental-workers-psychology-business-and-the-humm-wadsworth-temperament-scale-in-interwar-america
#8
Kira Lussier
This article traces the history of a popular interwar psychological test, the Humm-Wadsworth Temperament Scale (HWTS), from its development in the early 1930s to its adoption by corporate personnel departments. In popular articles, trade magazines, and academic journals, industrial psychologist Doncaster Humm and personnel manager Guy Wadsworth trumpeted their scale as a scientific measure of temperament that could ensure efficient hiring practices and harmonious labor relations by screening out "problem employees" and screening for temperamentally "normal" workers...
February 5, 2018: History of Psychology
https://www.readbyqxmd.com/read/29389175/comparability-of-structured-interview-of-reported-symptoms-sirs-and-structured-interview-of-reported-symptoms-second-edition-sirs-2-classifications-with-external-response-bias-criteria
#9
Jessica L Tylicki, Dustin B Wygant, Anthony M Tarescavage, Richard I Frederick, Elizabeth A Tyner, Robert P Granacher, Martin Sellbom
Rogers, Sewell, and Gillard (2010) released a revised version of the Structured Interview of Reported Symptoms (SIRS; Rogers, Bagby, & Dickens, 1992), the SIRS-2, which introduced several new scales, indices, and a new classification model with the overall goal of improving its classification of genuine versus feigned presentations. Since the release of the SIRS-2, several concerns have been raised regarding the quality of the SIRS-2 development and validation samples and the method used to calculate classification accuracy estimates...
February 1, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29319367/development-and-validation-of-personality-disorder-spectra-scales-for-the-mmpi-2-rf
#10
Martin Sellbom, Mark H Waugh, Christopher J Hopwood
The purpose of this study was to develop and validate a set of MMPI-2-RF (Ben-Porath & Tellegen, 2008/2011) personality disorder (PD) spectra scales. These scales could serve the purpose of assisting with DSM-5 PD diagnosis and help link categorical and dimensional conceptions of personality pathology within the MMPI-2-RF. We developed and provided initial validity results for scales corresponding to the 10 PD constructs listed in the DSM-5 using data from student, community, clinical, and correctional samples...
January 10, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29259322/hubness-of-strategic-planning-and-sociality-influences-depressive-mood-and-anxiety-in-college-population
#11
Je-Yeon Yun, Yoobin Choi, Yoonhee Kwon, Hwa Young Lee, Soo-Hee Choi, Joon Hwan Jang
Depressive mood and anxiety can reduce cognitive performance. Conversely, the presence of a biased cognitive tendency may serve as a trigger for depressive mood-anxiety. Previous studies have largely focused on group-wise correlations between clinical-neurocognitive variables. Using network analyses for intra-individual covariance, we sought to decipher the most influential clinical-neurocognitive hub in the differential severity of depressive-anxiety symptoms in a college population. Ninety college students were evaluated for depressive-anxiety symptoms, Minnesota multiphasic personality inventory-2(MMPI-2), and neuro-cognition...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227127/symptom-and-performance-validity-with-veterans-assessed-for-attention-deficit-hyperactivity-disorder-adhd
#12
Robert D Shura, John H Denning, Holly M Miskey, Jared A Rowland
Little is known about attention-deficit/hyperactivity disorder (ADHD) in veterans. Practice standards recommend the use of both symptom and performance validity measures in any assessment, and there are salient external incentives associated with ADHD evaluation (stimulant medication access and academic accommodations). The purpose of this study was to evaluate symptom and performance validity measures in a clinical sample of veterans presenting for specialty ADHD evaluation. Patients without a history of a neurocognitive disorder and for whom data were available on all measures (n = 114) completed a clinical interview structured on DSM-5 ADHD symptoms, the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF), and the Test of Memory Malingering Trial 1 (TOMM1) as part of a standardized ADHD diagnostic evaluation...
December 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29172098/social-defeat-as-a-mediator-of-the-relationship-between-childhood-trauma-and-paranoid-ideation
#13
Jihyeon Seo, Ji Young Choi
Social defeat, the subjective experience of viewing oneself as a failure or social outsider, is associated with various psychiatric disorders. Recent studies suggest that social defeat may play an important role in the development of psychotic disorders. This study examined the role of social defeat in the relationship between childhood trauma and paranoid ideation, a symptom of psychosis, in non-psychotic mental disorders. Psychiatric patients (N = 199) completed the Korean version of the Childhood Trauma Questionnaire, the Korean version of the Defeat Scale, and Restructured Clinical Scale 6 (Ideas of Persecution) of the Korean version of the Minnesota Multiphasic Personality Inventory-2...
November 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29169252/distinguishing-levels-of-suicide-risk-in-depressed-male-veterans-the-role-of-internalizing-and-externalizing-psychopathology-as-measured-by-the-mmpi-2-rf
#14
Stephanie N Miller, Melanie L Bozzay, Yossef S Ben-Porath, Paul A Arbisi
Suicide occurs at high rates among veterans, underscoring a need for improved identification of veterans at risk of engaging in suicidal behavior. Considering dimensions of psychopathology in the context of an ideation-to-action framework, the present study examined the utility of the Minnesota Multiphasic Personality Inventory-2-Restructured Form in distinguishing depressed, psychiatrically hospitalized male veterans ( N = 430) at varying levels of suicide risk. Analysis of variance and hierarchical logistic regression analyses indicated that internalizing scales differentiated depressed ideators ( n = 147) and depressed controls ( n = 143); and in line with expectations, both broad and narrowly focused externalizing scales provided incremental validity in distinguishing depressed attempters ( n = 140) from depressed ideators...
November 1, 2017: Assessment
https://www.readbyqxmd.com/read/29157511/subtypes-of-homicide-offenders-based-on-psychopathic-traits
#15
Marija Pajevic, Borjanka Batinic, Nikola Stevanovic
The aim of the present study was to explore the subtypes of offenders based on psychopathic traits in a sample of 127 adult homicide offenders (n=40.3% convicted of murder, n=32.6% convicted of aggravated murder, n=27.1% convicted of attempted murder). A two-step cluster analysis of the four factors of psychopathy yielded three clusters, which were then compared on the general dimensions of personality defined by the HEXACO model, intelligence, sadism and psychopathology variables conceptualized by the MMPI-202...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29111906/types-of-smokers-who-seek-smoking-cessation-treatment-according-to-psychopathology
#16
Úrsula Martínez, Elena Fernández Del Río, Ana López-Durán, Carmela Martínez-Vispo, Elisardo Becoña
Psychopathology and psychological distress have been shown to be related to poor smoking cessation outcomes and abstinence maintenance. Thus, it is important to identify individuals with high levels of psychopathology before undergoing smoking cessation treatment in order to increase their likelihood of success. OBJECTIVE: The primary aim of the present study was to analyze whether we could classify smokers by using self-reported measures of psychopathology. In addition, a secondary aim was to examine if there were significant differences among the groups of smokers regarding sociodemographic information, nicotine dependence, and cessation rates at the end of treatment and at 6- and 12-month follow-ups...
November 7, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29079383/surgery-type-and-psychosocial-factors-contribute-to-poorer-weight-loss-outcomes-in-persons-with-a-body-mass-index-greater-than-60-kg-m-2
#17
Ryan J Marek, Gail A Williams, Samantha H Mohun, Leslie J Heinberg
BACKGROUND: The current investigation aims to predict 3-year postoperative percent total weight loss among a sample of bariatric surgery patients with super-super obesity. OBJECTIVE: Previous research implies that persons with presurgical super-super obesity (body mass index [BMI] ≥60 kg/m2 ) tend to have poorer loss outcomes compared with those with a lower presurgical BMI after bariatric surgery. SETTING: Cleveland Clinic, Bariatric & Metabolic Institute, Cleveland, OH...
December 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29072481/classification-accuracy-of-the-minnesota-multiphasic-personality-inventory-2-mmpi-2-restructured-form-validity-scales-in-detecting-malingered-pain-related-disability
#18
Kevin J Bianchini, Luis E Aguerrevere, Kelly L Curtis, Tresa M Roebuck-Spencer, F Charles Frey, Kevin W Greve, Matthew Calamia
The symptom reports of individuals with chronic pain are multidimensional (e.g., emotional, cognitive, and somatic) and significantly contribute to increased morbidity and lost work productivity. When pain occurs in the context of a legally compensable event, reliable assessment of a patient's multifactorial symptom experience during psychological or neuropsychological evaluations is a necessity. The Validity Scales of the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) have been shown useful in identifying symptom overreporting and feigning within chronic pain samples and a number of studies have emerged supporting the use of the MMPI-2-Restructured Form (MMPI-2-RF) in the detection of simulated or feigned impairment in a variety of populations...
October 26, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29035666/examination-of-risk-for-sleep-disordered-breathing-among-college-football-players
#19
Bailey Peck, Timothy Renzi, Hannah Peach, Jane Gaultney, Joseph S Marino
CONTEXT: Professional football linemen are at risk for sleep disordered breathing (SDB) compared to other types of athletes. It is currently unknown whether collegiate football linemen display a similar risk profile. OBJECTIVE: 1) Determine for the first time whether collegiate football linemen show risk for SDB, and 2) Test the hypothesis that SDB risk is higher in collegiate football linemen compared to an athletic comparison group. DESIGN: Descriptive laboratory study...
October 16, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29030007/pretreatment-of-a-matrix-metalloproteases-inhibitor-and-aprotinin-attenuated-the-development-of-acute-pancreatitis-induced-lung-injury-in-rat-model
#20
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
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