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https://www.readbyqxmd.com/read/29149976/clinical-challenges-of-tacrolimus-for-maintenance-immunosuppression-post-lung-transplantation
#1
S Ivulich, M Dooley, C Kirkpatrick, G Snell
Lung transplantation (LTx) is a successful treatment option for end-stage lung disease, and immunosuppressant regimens, utilized to prevent rejection of the transplanted graft, are paramount to maintaining long-term graft survival. Immunosuppression can be classified as induction, maintenance, and antirejection therapy. This article focuses on maintenance immunosuppression that includes a combination of a calcineurin inhibitor (CNI), cell cycle inhibitor, and corticosteroid. CNIs remain the cornerstone of immunosuppression following LTx, and tacrolimus is now the preferred CNI, based on a better adverse effect profile and some limited evidence for enhanced efficacy...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29146281/nucleus-accumbens-core-lesions-induce-sub-optimal-choice-and-reduce-sensitivity-to-magnitude-and-delay-in-impulsive-choice-tasks
#2
Catherine C Steele, Jennifer R Peterson, Andrew T Marshall, Sarah L Stuebing, Kimberly Kirkpatrick
The nucleus accumbens core (NAc) has long been recognized as an important contributor to the computation of reward value that is critical for impulsive choice behavior. Impulsive choice refers to choosing a smaller-sooner (SS) over a larger-later (LL) reward when the LL is more optimal in terms of the rate of reward delivery. Two experiments examined the role of the NAc in impulsive choice and its component processes of delay and magnitude processing. Experiment 1 delivered an impulsive choice task with manipulations of LL reward magnitude, followed by a reward magnitude discrimination task...
November 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29129227/t-and-b-cell-activation-profiles-from-cows-with-and-without-johne-s-disease-in-response-to-in-vitro-stimulation-with-mycobacterium-avium-subspecies-paratuberculosis
#3
Meredith C Frie, Kelly R B Sporer, Brian W Kirkpatrick, Paul M Coussens
Johne's disease (JD) is a chronic wasting disease of ruminants caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP). JD is particularly problematic on US dairy farms: estimates show that over 50% of farms are MAP-contaminated and as many as 91% of dairy herds could be infected. Although estimates vary widely, JD may cost the dairy industry between $200 million and $1.5 billion every year. One major obstacle to JD management is that JD is difficult to detect in many animals, in part due to the variable immunity against MAP demonstrated by JD+ cattle...
December 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29126609/meta-analysis-of-adult-height-and-birth-length-in-schizophrenia
#4
Keely Latham, Brian Kirkpatrick
OBJECTIVE: As a group, people with schizophrenia have a number of subtle anatomical abnormalities as well as physiological abnormalities that precede antipsychotic treatment. Some studies have also found shorter birth length or shorter adult height in people with schizophrenia compared to control subjects. We performed a systematic review and meta-analysis of studies of birth length and adult height in schizophrenia, following PRISMA guidelines (Prospero Registration # CRD42016043718)...
November 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29121966/radioprotective-agents-to-prevent-cellular-damage-due-to-ionizing-radiation
#5
REVIEW
Tyler A Smith, Daniel R Kirkpatrick, Sean Smith, Trevor K Smith, Tate Pearson, Aparna Kailasam, Kortney Z Herrmann, Johanna Schubert, Devendra K Agrawal
Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone...
November 9, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29120302/foods-and-beverages-available-to-children-in-settings-outside-of-the-home-research-policy-and-monitoring-considerations
#6
Sharon I Kirkpatrick
No abstract available.
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29120214/reinforcement-learning-models-of-risky-choice-and-the-promotion-of-risk-taking-by-losses-disguised-as-wins-in-rats
#7
Andrew T Marshall, Kimberly Kirkpatrick
Risky decisions are inherently characterized by the potential to receive gains or incur losses, and these outcomes have distinct effects on subsequent decision-making. One important factor is that individuals engage in loss-chasing, in which the reception of a loss is followed by relatively increased risk-taking. Unfortunately, the mechanisms of loss-chasing are poorly understood, despite the potential importance for understanding pathological choice behavior. The goal of the present experiment was to illuminate the mechanisms governing individual differences in loss-chasing and risky-choice behaviors...
July 2017: Journal of Experimental Psychology. Animal Learning and Cognition
https://www.readbyqxmd.com/read/29117744/twelve-tips-to-promote-successful-development-of-a-learner-performance-dashboard-within-a-medical-education-program
#8
Christy Boscardin, Kirkpatrick B Fergus, Bonnie Hellevig, Karen E Hauer
Easily accessible and interpretable performance data constitute critical feedback for learners that facilitate informed self-assessment and learning planning. To provide this feedback, there has been a proliferation of educational dashboards in recent years. An educational (learner) dashboard systematically delivers timely and continuous feedback on performance and can provide easily visualized and interpreted performance data. In this paper, we provide practical tips for developing a functional, user-friendly individual learner performance dashboard and literature review of dashboard development, assessment theory, and users' perspectives...
November 9, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29110295/prevalence-and-variability-in-medications-contributing-to-polypharmacy-in-long-term-care-facilities
#9
Natali Jokanovic, Kris M Jamsen, Edwin C K Tan, Michael J Dooley, Carl M Kirkpatrick, J Simon Bell
BACKGROUND: Research into which medications contribute to polypharmacy and the variability in these medications across long-term care facilities (LTCFs) has been minimal. OBJECTIVE: Our objective was to investigate which medications were more prevalent among residents with polypharmacy and to determine the variability in prescribing of these medications across LTCFs. METHODS: This was a cross-sectional study of 27 LTCFs in regional and rural Victoria, Australia...
December 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29096910/-french-translation-and-validation-of-a-short-version-of-the-suicide-intervention-response-inventory-2-siri-2-vf
#10
C Kopp-Bigault, Y Audouard-Marzin, P Scouarnec, G Beauchamp, M Séguin, M Walter
OBJECTIVES: Training health professionals about suicidal crisis is one major line of suicide prevention worldwide. France has one of the highest suicide rates in Europe, and although crisis intervention training has been set up since 2001, there presently is no training assessment tool in the French language for health professionals trained in suicide prevention. In the four levels of Kirpatrick's education pyramid, training that takes place in France today solely assesses level one status, that is to say relative to the level of satisfaction of participants (self-report)...
October 30, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29094787/functional-dysconnectivity-of-the-limbic-loop-of-frontostriatal-circuits-in-first-episode-treatment-naive-schizophrenia
#11
Pan Lin, Xiaosheng Wang, Bei Zhang, Brian Kirkpatrick, Dost Öngür, James J Levitt, Jorge Jovicich, Shuqiao Yao, Xiang Wang
Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ-related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first-episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects...
November 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29091238/enhancing-critical-thinking-via-a-clinical-scholar-approach
#12
Vicki Simpson, Sara A McComb, Jane M Kirkpatrick
BACKGROUND: Safety, quality improvement, and a systems perspective are vital for nurses to provide quality evidence-based care. Responding to the call to prepare nurses with these perspectives, one school of nursing used a clinical scholar approach, enhanced by systems engineering to more intentionally develop the ability to clinically reason and apply evidence-based practice. METHOD: A two-group, repeated-measures control trial was used to determine the effects of systems engineering content and support on nursing students' clinical judgment and critical thinking skills...
November 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/29089870/tunneling-nanotubes-and-gap-junctions-their-role-in-long-range-intercellular-communication-during-development-health-and-disease-conditions
#13
REVIEW
Jennifer Ariazi, Andrew Benowitz, Vern De Biasi, Monique L Den Boer, Stephanie Cherqui, Haifeng Cui, Nathalie Douillet, Eliseo A Eugenin, David Favre, Spencer Goodman, Karine Gousset, Dorit Hanein, David I Israel, Shunsuke Kimura, Robert B Kirkpatrick, Nastaran Kuhn, Claire Jeong, Emil Lou, Robbie Mailliard, Stephen Maio, George Okafo, Matthias Osswald, Jennifer Pasquier, Roel Polak, Gabriele Pradel, Bob de Rooij, Peter Schaeffer, Vytenis A Skeberdis, Ian F Smith, Ahmad Tanveer, Niels Volkmann, Zhenhua Wu, Chiara Zurzolo
Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described tunneling nanotubes (TNTs). It is unknown whether a combination of these communication mechanisms such as TNTs and gap junctions may be important, but further research is required. TNTs are long cytoplasmic bridges that enable long-range, directed communication between connected cells...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29082998/water-dynamics-in-hydrated-amorphous-materials-a-molecular-dynamics-study-of-the-effects-of-dehydration-in-amorphous-calcium-carbonate
#14
Moumita Saharay, R James Kirkpatrick
Amorphous calcium carbonate (ACC) is often a critical transient phase in the formation of crystalline phases of CaCO3via dehydration of hydrated ACC. The behavior of the water molecules plays a pivotal role in this transformation. We report here the dynamics of water molecules in ACC at hydration levels from CaCO3·1H2O to CaCO3·0.25H2O using molecular dynamics (MD) simulations. Due to the presence of highly hydrophilic Ca(2+) and the strong H-bond acceptor CO3(2-), most of the water molecules in our simulations have restricted translational and orientational dynamics...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29078873/improving-the-efficacy-of-liposome-mediated-vascular-gene-therapy-via-lipid-surface-modifications
#15
Richard K Fisher, Samuel I Mattern-Schain, Michael D Best, Stacy S Kirkpatrick, Michael B Freeman, Oscar H Grandas, Deidra J H Mountain
BACKGROUND: We have previously defined mechanisms of intimal hyperplasia that could be targets for molecular therapeutics aimed at vascular pathology. However, biocompatible nanocarriers are needed for effective delivery. Cationic liposomes (CLPs) have been demonstrated as effective nanocarriers in vitro. However, in vivo success has been hampered by cytotoxicity. Recently, neutral PEGylated liposomes (PLPs) have been modified with cell-penetrating peptides (CPPs) to enhance cellular uptake...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29076955/knowledge-and-preferences-regarding-antidepressant-medication-among-depressed-latino-patients-in-primary-care
#16
Bonnie L Green, Maria Rosa Watson, Stacey I Kaltman, Adriana Serrano, Nicholas Talisman, Laura Kirkpatrick, Marcela Campoli
US Latinos are less likely to utilize mental health services than non-Latino whites and to take antidepressant medications. This mixed-method study followed a subset (N = 28) of a research sample of depressed Latino immigrant primary care patients, who took depression medication, with a telephone interview to study their knowledge about and experiences with antidepressant medications. Most (82%) reported taking medication for 2 months or more, and 75% reported feeling better, whereas more than half reported side effects...
October 25, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29076631/patient-and-public-involvement-in-the-design-of-clinical-trials-an-overview-of-systematic-reviews
#17
REVIEW
Amy Price, Loai Albarqouni, Jo Kirkpatrick, Mike Clarke, Su May Liew, Nia Roberts, Amanda Burls
BACKGROUND: Funders encourage lay-volunteer inclusion in research. There are controversy and resistance, given concerns of role confusion, exploratory methods, and limited evidence about what value lay-volunteers bring to research. This overview explores these areas. METHODS: Eleven databases were searched without date or language restrictions for systematic reviews of public and patient involvement (PPI) in clinical trials design. This systematic overview of PPI included 27 reviews from which areas of good and bad practice were identified...
October 27, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29075316/proceedings-of-resources-for-optimal-care-of-acute-care-and-emergency-surgery-consensus-summit-donegal-ireland
#18
M Sugrue, R Maier, E E Moore, M Boermeester, F Catena, F Coccolini, A Leppaniemi, A Peitzman, G Velmahos, L Ansaloni, F Abu-Zidan, P Balfe, C Bendinelli, W Biffl, M Bowyer, M DeMoya, J De Waele, S Di Saverio, A Drake, G P Fraga, A Hallal, C Henry, T Hodgetts, L Hsee, S Huddart, A W Kirkpatrick, Y Kluger, L Lawler, M A Malangoni, M Malbrain, P MacMahon, K Mealy, M O'Kane, P Loughlin, M Paduraru, L Pearce, B M Pereira, A Priyantha, M Sartelli, K Soreide, C Steele, S Thomas, J L Vincent, L Woods
BACKGROUND: Opportunities to improve emergency surgery outcomes exist through guided better practice and reduced variability. Few attempts have been made to define optimal care in emergency surgery, and few clinically derived key performance indicators (KPIs) have been published. A summit was therefore convened to look at resources for optimal care of emergency surgery. The aim of the Donegal Summit was to set a platform in place to develop guidelines and KPIs in emergency surgery. METHODS: The project had multidisciplinary global involvement in producing consensus statements regarding emergency surgery care in key areas, and to assess feasibility of producing KPIs that could be used to monitor process and outcome of care in the future...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29071440/reduction-of-the-relative-centrifugal-force-influences-cell-number-and-growth-factor-release-within-injectable-prf-based-matrices
#19
Simon Wend, Alica Kubesch, Anna Orlowska, Sarah Al-Maawi, Niklas Zender, Andre Dias, Richard J Miron, Robert Sader, Patrick Booms, C James Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet rich fibrin (PRF) is a blood concentrate system obtained by centrifugation of peripheral blood. First PRF matrices exhibited solid fibrin scaffold, more recently liquid PRF-based matrix was developed by reducing the relative centrifugation force and time. The aim of this study was to systematically evaluate the influence of RCF (relative centrifugal force) on cell types and growth factor release within injectable PRF- in the range of 60-966 g using consistent centrifugation time. Numbers of cells was analyzed using automated cell counting (platelets, leukocytes, neutrophils, lymphocytes and monocytes) and histomorphometrically (CD 61, CD- 45, CD-15+, CD-68+, CD-3+ and CD-20)...
October 25, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29066417/combined-aerosolized-toll-like-receptor-ligands-are-an-effective-therapeutic-agent-against-influenza-pneumonia-when-co-administered-with-oseltamivir
#20
Miguel M Leiva-Juarez, Carson T Kirkpatrick, Brian E Gilbert, Brenton Scott, Michael J Tuvim, Burton F Dickey, Scott E Evans, Diane Markesich
Influenza pneumonia remains a common and debilitating viral infection despite vaccination programs and antiviral agents developed for prophylaxis and treatment. The neuraminidase inhibitor oseltamivir is frequently prescribed for established influenza A virus infections, but the emergence of neuraminidase inhibitor resistant viruses, a brief therapeutic window and competing diagnoses complicate its use. PUL-042 is a clinical stage, aerosol drug comprised of synthetic ligands for Toll-like receptor (TLR) 2/6 and TLR 9...
October 21, 2017: European Journal of Pharmacology
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