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https://www.readbyqxmd.com/read/28230518/pectus-excavatum-first-ultrastructural-findings-of-a-potential-ciliopathy
#1
Christoph Brochhausen, Andreas Mamilos, Salmai Turial, C James Kirkpatrick
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230514/brush-or-scratch-which-biopsy-is-superior-for-the-ultrastructural-diagnosis-of-primary-ciliary-dyskinesia-a-retrospective-analysis
#2
Christoph Brochhausen, Andreas Mamilos, C James Kirkpatrick
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28227310/analysis-of-glottal-source-parameters-in-parkinsonian-speech
#3
Jane Hanratty, Catherine Deegan, Mary Walsh, Barry Kirkpatrick, Jane Hanratty, Catherine Deegan, Mary Walsh, Barry Kirkpatrick, Mary Walsh, Barry Kirkpatrick, Jane Hanratty, Catherine Deegan
Diagnosis and monitoring of Parkinson's disease has a number of challenges as there is no definitive biomarker despite the broad range of symptoms. Research is ongoing to produce objective measures that can either diagnose Parkinson's or act as an objective decision support tool. Recent research on speech based measures have demonstrated promising results. This study aims to investigate the characteristics of the glottal source signal in Parkinsonian speech. An experiment is conducted in which a selection of glottal parameters are tested for their ability to discriminate between healthy and Parkinsonian speech...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28208883/fostering-educational-research-among-medical-teachers-evaluation-of-a-faculty-development-program-in-india
#4
Tripti K Srivastava, Lalitbhushan S Waghmare, Alka Rawekar, Ved Prakash Mishra
INTRODUCTION: Medical education can be enormously benefitted from research. Since clinicians/medical teachers are directly involved in teaching learning processes, they should participate in Educational Research (ER) practices to generate evidence and insights about teaching learning. Faculty Development Program (FDP) has a positive influence amongst health professionals and therefore can prove to be of consequence in instilling a strong educational research culture. AIM: Present study was undertaken to evaluate the efficacy of a Faculty Development Fellowship Program in Medical Education to foster educational research culture amongst medical teachers...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208819/the-comparative-reliability-and-feasibility-of-the-past-year-canadian-diet-history-questionnaire-ii-comparison-of-the-paper-and-web-versions
#5
Geraldine Lo Siou, Ilona Csizmadi, Beatrice A Boucher, Alianu K Akawung, Heather K Whelan, Michelle Sharma, Ala Al Rajabi, Jennifer E Vena, Sharon I Kirkpatrick, Anita Koushik, Isabelle Massarelli, Isabelle Rondeau, Paula J Robson
Advances in technology-enabled dietary assessment include the advent of web-based food frequency questionnaires, which may reduce costs and researcher burden but may introduce new challenges related to internet connectivity and computer literacy. The purpose of this study was to evaluate the intra- and inter-version reliability, feasibility and acceptability of the paper and web Canadian Diet History Questionnaire II (CDHQ-II) in a sub-sample of 648 adults (aged 39-81 years) recruited from Alberta's Tomorrow Project...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28198164/influence-of-maternal-and-socioeconomic-factors-on-breast-milk-fatty-acid-composition-in-urban-low-income-families
#6
Uma Nayak, Suman Kanungo, Dadong Zhang, E Ross Colgate, Marya P Carmolli, Ayan Dey, Masud Alam, Byomkesh Manna, Ranjan Kumar Nandy, Deok Ryun Kim, Dilip Kumar Paul, Saugato Choudhury, Sushama Sahoo, William S Harris, Thomas F Wierzba, Tahmeed Ahmed, Beth D Kirkpatrick, Rashidul Haque, William A Petri, Josyf C Mychaleckyj
The lipid composition of breast milk may have a significant impact on early infant growth and cognitive development. Comprehensive breast milk data is lacking from low-income populations in the Indian subcontinent impeding assessment of deficiencies and limiting development of maternal nutritional interventions. A single breast milk specimen was collected within 6 weeks postpartum from two low-income maternal cohorts of exclusively breastfed infants, from Dhaka, Bangladesh (n = 683) and Kolkata, India (n = 372) and assayed for percentage composition of 26 fatty acids...
February 15, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28186553/anhedonia-and-abstinence-as-predictors-of-the-subjective-pleasantness-of-positive-negative-and-smoking-related-pictures
#7
Casey R Guillot, Teresa M Halliday, Matthew G Kirkpatrick, Raina D Pang, Adam M Leventhal
No abstract text is available yet for this article.
February 10, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28185092/thermal-analysis-and-stability-of-commercially-available-endodontic-obturation-materials
#8
H W Roberts, T C Kirkpatrick, B E Bergeron
OBJECTIVES: The purpose of this study was to evaluate the thermal stability of 23 commercially-available endodontic obturation materials. MATERIALS AND METHODS: Specimens (n = 10) were sealed in aluminum differential scanning calorimetry (DSC) crucibles and subjected to thermal scan series consisting of a 25 to 70 °C at 5 °C/min followed by a rapid increase to 230 °C, followed by a second scan from 25 to 70 °C at 5 °C/min. The first scan evaluated the materials as-received followed by a worse-case-scenario thermal challenge simulating temperatures involved with warm vertical condensation obturation techniques...
February 10, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28184390/gold-nanoparticle-interactions-with-endothelial-cells-cultured-under-physiological-conditions
#9
C Freese, L Anspach, R C Deller, S-J Richards, M I Gibson, C J Kirkpatrick, R E Unger
PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and cancer treatment. No impact of PEGylated AuNPs on the barrier forming properties of endothelial cells (ECs) has been reported, but recent studies demonstrated that unexpected effects on erythrocytes are observed. Almost all studies to date have been with static-cultured ECs. Herein, ECs maintained under physiological cyclic stretch and flow conditions and used to generate a blood-brain barrier model were exposed to 20 nm PEGylated AuNPs...
February 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28178913/training-us-health-care-professionals-on-human-trafficking-where-do-we-go-from-here
#10
Clydette Powell, Kirsten Dickins, Hanni Stoklosa
: Some 21 million adults and children are labor-trafficked or sex-trafficked through force, fraud, or coercion. In recognition of the interface between trafficking victims and the healthcare setting, over the last 10 years there has been a notable increase in training of health care professionals (HCPs) on human trafficking (HT) and its health implications. Many organizations have developed curricula and offered training in various clinical settings. However, methods and content of this education on trafficking vary widely, and there is little evaluation of the impact of the training...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28178305/clinical-utility-of-c-reactive-protein-to-predict-treatment-response-during-cystic-fibrosis-pulmonary-exacerbations
#11
Ashutosh Sharma, Gordon Kirkpatrick, Virginia Chen, Kate Skolnik, Zsuzsanna Hollander, Pearce Wilcox, Bradley S Quon
RATIONALE: C-reactive protein (CRP) is a systemic marker of inflammation that correlates with disease status in cystic fibrosis (CF). The clinical utility of CRP measurement to guide pulmonary exacerbation (PEx) treatment decisions remains uncertain. OBJECTIVES: To determine whether monitoring CRP during PEx treatment can be used to predict treatment response. We hypothesized that early changes in CRP can be used to predict treatment response. METHODS: We reviewed all PEx events requiring hospitalization for intravenous (IV) antibiotics over 2 years at our institution...
2017: PloS One
https://www.readbyqxmd.com/read/28176362/interdisciplinary-pharmacometrics-linking-oseltamivir-pharmacology-influenza-epidemiology-and-health-economics-to-inform-antiviral-use-in-pandemics
#12
M A Kamal, P F Smith, N Chaiyakunapruk, D B C Wu, C Pratoomsoot, K K C Lee, H Y Chong, R E Nelson, K Nieforth, G Dall, S Toovey, D C M Kong, A Kamauu, C M Kirkpatrick, C R Rayner
AIM: A modular interdisciplinary platform was developed to investigate the economic impact of oseltamivir treatment by dosage regimen under simulated influenza pandemic scenarios. METHODS: The pharmacology module consisted of a pharmacokinetic distribution of oseltamivir carboxylate AUC0-24h at steady state (simulated for 75 mg and 150 mg BID regimens for 5 days) and a pharmacodynamic distribution of viral shedding duration (Tshed ) obtained from phase II influenza inoculation data...
February 8, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28159573/factors-associated-with-the-control-of-viral-replication-and-virologic-breakthrough-in-a-recently-infected-hiv-1-controller
#13
Victoria E Walker-Sperling, Christopher W Pohlmeyer, Rebecca T Veenhuis, Megan May, Krystle A Luna, Allison R Kirkpatrick, Oliver Laeyendecker, Andrea L Cox, Mary Carrington, Justin R Bailey, Roberto C Arduino, Joel N Blankson
HIV-1 controllers are patients who control HIV-1 viral replication without antiretroviral therapy. Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood. We describe a patient who presented with acute HIV-1 infection and was found to have an HIV-1 RNA level of <100copies/mL. She did not have any known protective HLA alleles, but significant immune activation of CD8+ T cells and natural killer (NK) cells was present, and both cell types inhibited viral replication...
January 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28158101/simulation-of-concave-convex-imaging-mirror-system-for-development-of-a-compact-and-achromatic-full-field-x-ray-microscope
#14
Jumpei Yamada, Satoshi Matsuyama, Yasuhisa Sano, Kazuto Yamauchi
We propose the use of two pairs of concave-convex mirrors as imaging optics for the compact full-field x-ray microscope with high resolution and magnification factors. The optics consists of two pairs of hyperbolic convex and elliptical concave mirrors with the principal surface near the object, consequently enabling the focal length to be 10 times shorter than conventional advanced Kirkpatrick-Baez mirror optics. This paper describes characteristics of the optics calculated by ray-tracing and wave-optical simulators...
February 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28157830/designing-a-physician-leadership-development-program-based-on-effective-models-of-physician-education
#15
Joseph Hopkins, Magali Fassiotto, Manwai Candy Ku, Dagem Mammo, Hannah Valantine
BACKGROUND: Because of modern challenges in quality, safety, patient centeredness, and cost, health care is evolving to adopt leadership practices of highly effective organizations. Traditional physician training includes little focus on developing leadership skills, which necessitates further training to achieve the potential of collaborative management. PURPOSE: The aim of this study was to design a leadership program using established models for continuing medical education and to assess its impact on participants' knowledge, skills, attitudes, and performance...
February 2, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28154130/trifunctional-lipid-probes-for-comprehensive-studies-of-single-lipid-species-in-living-cells
#16
Doris Höglinger, André Nadler, Per Haberkant, Joanna Kirkpatrick, Martina Schifferer, Frank Stein, Sebastian Hauke, Forbes D Porter, Carsten Schultz
Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid-protein interactions, and intracellular lipid localization with a single tool per target lipid. The probes are equipped with two photoreactive groups to allow photoliberation (uncaging) and photo-cross-linking in a sequential manner, as well as a click-handle for subsequent functionalization...
February 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28152773/bringing-person-centered-care-to-practice-with-cco-s-guideline-for-person-centred-care-in-adult-oncology-services
#17
Brett Nicholls, Hannah Shamji, Neil Johnson, Caroline Zwaal, Christian Stevens, Rhonel Biddy, Carly Griffin, Gail Laroque, Hans Messersmith, Simron Singh
: 65 Background: CCO ensures quality cancer care for 16 million residents in Ontario. CCO has identified person-centered care (PCC) as a top strategy in driving the quality agenda. CCO, in collaboration with the Program in Evidence-Based Care, developed a PCC Guideline to set the standard of care for people experiencing cancer in Ontario. A PCC video was developed as a tool for translating this knowledge to support healthcare providers to integrate Guideline recommendations into their practice...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28148797/patterns-of-cellular-immunity-associated-with-experimental-infection-with-rden2%C3%AE-30-tonga-74-supports-its-suitability-as-a-human-denv-challenge-strain
#18
Alba Grifoni, Michael Angelo, John Sidney, Sinu Paul, Bjoern Peters, Aruna D de Silva, Elizabeth Phillips, Simon Mallal, Sean A Diehl, Jason Botten, Jonathan Boyson, Beth D Kirkpatrick, Stephen S Whitehead, Anna P Durbin, Alessandro Sette, Daniela Weiskopf
: A deletion variant of the DENV2 Tonga/74 strain lacking 30 nucleotides from its 3' untranslated region (rDEN2Δ30) has previously been established for use in a controlled DENV human challenge model. To evaluate if this model is appropriate to derive correlates of protection for DENV vaccines based on cellular immunity, we wanted to compare how the cellular immune response to this challenge strain compares to the response induced by natural infection. To achieve this, we predicted HLA class I and class II restricted peptides from rDEN2Δ30 and used them, in an IFN-gamma ELISPOT assay, to interrogate CD8(+) and CD4(+) T cell responses in healthy volunteers infected with rDEN2Δ30...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28146125/lessons-from-studies-to-evaluate-an-online-24-hour-recall-for-use-with-children-and-adults-in-canada
#19
Sharon I Kirkpatrick, Anne M Gilsing, Erin Hobin, Nathan M Solbak, Angela Wallace, Jess Haines, Alexandra J Mayhew, Sarah K Orr, Parminder Raina, Paula J Robson, Jocelyn E Sacco, Heather K Whelan
With technological innovation, comprehensive dietary intake data can be collected in a wide range of studies and settings. The Automated Self-Administered 24-hour (ASA24) Dietary Assessment Tool is a web-based system that guides respondents through 24-h recalls. The purpose of this paper is to describe lessons learned from five studies that assessed the feasibility and validity of ASA24 for capturing recall data among several population subgroups in Canada. These studies were conducted within a childcare setting (preschool children with reporting by parents), in public schools (children in grades 5-8; aged 10-13 years), and with community-based samples drawn from existing cohorts of adults and older adults...
January 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28145767/examining-guidelines-for-school-based-breakfast-programs-in-canada-a-systematic-review-of-the-grey-literature
#20
Katelyn M Godin, Sharon I Kirkpatrick, Rhona M Hanning, Jackie Stapleton, Scott T Leatherdale
School breakfast programs are widespread and serve varying objectives regarding youth health promotion. Evidence-based guidelines for breakfast programs may be important in maximizing their effectiveness related to student outcomes, yet it is unclear what is available in Canada. A systematic review was conducted to identify and compare Canadian guidelines related to breakfast programs. Data sources included grey literature databases, customized search engines, targeted websites, and content expert consultations...
February 1, 2017: Canadian Journal of Dietetic Practice and Research
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