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https://www.readbyqxmd.com/read/28532911/lateral-transpsoas-approach-to-the-lumbar-spine-and-relationship-of-the-ureter-anatomical-study-with-application-to-minimizing-complications
#1
Vlad Voin, Christina Kirkpatrick, Fernando Alonso, Tarush Rastugi, Filipe H Sanders, Doniel Drazin, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: Complications from lateral lumbar interbody fusion procedures range from neurological deficits to organs and blood vessel to injuries. Injury to the ureter has been reported though uncommon. The present study was performed to elucidate the anatomical relationship of the ureter to this surgical approach. METHODS: Eight adult cadavers (16 sides) were placed in the full lateral position and the distal ureter cannulated with a metal wire, which was passed up to the kidney...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28529463/nutrition-practices-and-knowledge-among-ncaa-division-iii-football-players
#2
Elizabeth Lea Abbey, Cynthia Joy Wright, Christina M Kirkpatrick
BACKGROUND: Participation in collegiate American football is physically demanding and may have long-term health implications, particularly in relation to cardiovascular and neurological health. National Collegiate Athletic Association (NCAA) Division III (DIII) football players are a relatively unstudied population, particularly in terms of their dietary habits and knowledge. The aim of the present study was to descriptively evaluate the dietary intake of DIII football players including a subset of linemen and assess the nutritional knowledge and sources of information of these athletes...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28509340/prf-based-matrices-to-improve-angiogenesis-in-an-in-vitro-co-culture-model-for-bone-tissue-engineering
#3
Eva Dohle, Karima El Bagdadi, Robert Sader, Joseph Choukroun, C James Kirkpatrick, Shahram Ghanaati
In the context of prevascularization strategies for tissue engineering purposes, co-culture systems consisting of outgrowth endothelial cells (OECs) and primary osteoblasts (pOBs) have been established as a promising in vitro tool to study regeneration mechanisms and to identify factors that might positively influence repair processes like wound healing or angiogenesis. The development of autologous injectable platelet rich fibrin (PRF), which can be generated from peripheral blood in a minimal invasive procedure, fulfils several requirements for clinically applicable cell-based tissue engineering strategies...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28505767/long-time-predictability-in-disordered-spin-systems-following-a-deep-quench
#4
J Ye, R Gheissari, J Machta, C M Newman, D L Stein
We study the problem of predictability, or "nature vs nurture," in several disordered Ising spin systems evolving at zero temperature from a random initial state: How much does the final state depend on the information contained in the initial state, and how much depends on the detailed history of the system? Our numerical studies of the "dynamical order parameter" in Edwards-Anderson Ising spin glasses and random ferromagnets indicate that the influence of the initial state decays as dimension increases. Similarly, this same order parameter for the Sherrington-Kirkpatrick infinite-range spin glass indicates that this information decays as the number of spins increases...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28502697/impact-of-high-flux-haemodialysis-on-the-probability-of-target-attainment-for-oral-amoxicillin-clavulanic-acid-combination-therapy
#5
Katrina Hui, Kashyap Patel, David C M Kong, Carl M J Kirkpatrick
Clearance of small molecules such as amoxicillin and clavulanic acid is expected to increase during high-flux haemodialysis, which may result in lower concentrations and thus reduced efficacy. To date, clearance of amoxicillin/clavulanic acid (AMC) during high-flux haemodialysis remains largely unexplored. Using published pharmacokinetic parameters, a two-compartment model with first-order input was simulated to investigate the impact of high-flux haemodialysis on the probability of target attainment (PTA) of orally administered AMC combination therapy...
May 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28502692/what-factors-determine-treatment-outcome-in-aneurysmal-subarachnoid-haemorrhage-in-the-modern-era-a-post-hoc-stash-analysis
#6
Mario Teo, Mathew R Guilfoyle, Carole Turner, Peter J Kirkpatrick
INTRODUCTION: The management of aneurysmal SAH has changed dramatically in the last few decades with the publication of a few major studies including The International Cooperative Study on the Timing of Aneurysm Surgery Study, International Subarachnoid Aneurysm Trial (ISAT). The aim of this study is to analyse the outcome of patients with aSAH based on a contemporary series, identify the risk factors for poor outcome, and focusing on patients with good grades aSAH (to match the ISAT cohort)...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28502071/update-from-the-abdominal-compartment-society-wsacs-on-intra-abdominal-hypertension-and-abdominal-compartment-syndrome-past-present-and-future-beyond-banff-2017
#7
Andrew W Kirkpatrick, Michael Sugrue, Jessica L McKee, Bruno M Pereira, Derek J Roberts, Jan J De Waele, Ari Leppaniemi, Janeth C Ejike, Annika Reintam Blaser, Scott D'Amours, Bart De Keulenaer, Manu L N G Malbrain
No abstract text is available yet for this article.
May 14, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28499421/patterns-of-use-and-appropriateness-of-antibiotics-prescribed-to-patients-receiving-haemodialysis-an-observational-study
#8
Katrina Hui, Michelle Nalder, Kirsty Buising, Aspasia Pefanis, Khai Y Ooi, Eugenie Pedagogos, Craig Nelson, Carl M J Kirkpatrick, David C M Kong
BACKGROUND: There are limited published data on the types and appropriateness of oral and intravenous (IV) antibiotics prescribed to patients receiving haemodialysis. This information is critical to optimise antibiotic prescribing. Therefore this study aims to describe the patterns of use and the appropriateness of oral and IV antibiotics prescribed to patients receiving haemodialysis. METHODS: This was a prospective, observational study across four community and two hospital inpatient haemodialysis units in Melbourne, Australia...
May 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28487390/activation-of-the-amino-acid-response-pathway-blunts-the-effects-of-cardiac-stress
#9
Pu Qin, Pelin Arabacilar, Roberta E Bernard, Weike Bao, Alan R Olzinski, Yuanjun Guo, Hind Lal, Stephen H Eisennagel, Michael C Platchek, Wensheng Xie, Julius Del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G Schnackenberg, Fe Wright, Michael P Quaile, Wendy S Halsey, Ashley M Hughes, Ganesh M Sathe, George P Livi, Robert B Kirkpatrick, Xiaoyan A Qu, Deepak K Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L Force, Gregory J Gatto, Erding Hu, Robert N Willette
BACKGROUND: The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects gene and protein expression in a variety of pathways and elicits antifibrotic, autophagic, and anti-inflammatory activities. However, little is known regarding its role in cardiac stress. Our aim was to investigate the effects of halofuginone, a prolyl-tRNA synthetase inhibitor, on the AAR pathway in cardiac fibroblasts, cardiomyocytes, and in mouse models of cardiac stress and failure...
May 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28484510/management-of-intra-abdominal-infections-recommendations-by-the-wses-2016-consensus-conference
#10
REVIEW
Massimo Sartelli, Fausto Catena, Fikri M Abu-Zidan, Luca Ansaloni, Walter L Biffl, Marja A Boermeester, Marco Ceresoli, Osvaldo Chiara, Federico Coccolini, Jan J De Waele, Salomone Di Saverio, Christian Eckmann, Gustavo P Fraga, Maddalena Giannella, Massimo Girardis, Ewen A Griffiths, Jeffry Kashuk, Andrew W Kirkpatrick, Vladimir Khokha, Yoram Kluger, Francesco M Labricciosa, Ari Leppaniemi, Ronald V Maier, Addison K May, Mark Malangoni, Ignacio Martin-Loeches, John Mazuski, Philippe Montravers, Andrew Peitzman, Bruno M Pereira, Tarcisio Reis, Boris Sakakushev, Gabriele Sganga, Kjetil Soreide, Michael Sugrue, Jan Ulrych, Jean-Louis Vincent, Pierluigi Viale, Ernest E Moore
This paper reports on the consensus conference on the management of intra-abdominal infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual World Society of Emergency Surgery (WSES) meeting. This document covers all aspects of the management of IAIs. The Grading of Recommendations Assessment, Development and Evaluation recommendation is used, and this document represents the executive summary of the consensus conference findings.
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28481883/in-a-randomized-trial-the-live-attenuated-tetravalent-dengue-vaccine-tv003-is-well-tolerated-and-highly-immunogenic-in-subjects-with-flavivirus-exposure-prior-to-vaccination
#11
Stephen S Whitehead, Anna P Durbin, Kristen K Pierce, Dan Elwood, Benjamin D McElvany, Ellen A Fraser, Marya P Carmolli, Cecilia M Tibery, Noreen A Hynes, Matthew Jo, Janece M Lovchik, Catherine J Larsson, Elena A Doty, Dorothy M Dickson, Catherine J Luke, Kanta Subbarao, Sean A Diehl, Beth D Kirkpatrick
ClinicalTrials.gov TV003.
May 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28472527/biopsy-of-enlarging-lesions-after-stereotactic-radiosurgery-for-brain-metastases-frequently-reveals-radiation-necrosis
#12
Jessica L Narloch, S Harrison Farber, Sarah Sammons, Frances McSherry, James E Herndon, Jenny K Hoang, Fang-Fang Yin, John H Sampson, Peter E Fecci, Kimberly L Blackwell, John P Kirkpatrick, Grace J Kim
Background: Stereotactic radiosurgery (SRS) offers excellent local control for brain metastases (BM) with low rates of toxicity. Radiation necrosis (RN) may occur after treatment and is challenging to distinguish from local recurrence (LR). We evaluated enlarging brain lesions following SRS that were subsequently biopsied to differentiate RN versus LR. Methods: This study reviewed patients receiving SRS for BM between 2008-2012 who underwent a biopsy for suspicion of RN versus LR on MRI imaging...
May 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28467135/using-the-critical-incident-technique-to-measure-long-term-outcomes-of-interprofessional-education
#13
Emily Graybill, Akilah Heggs, Stephen Truscott, Erin Vinoski, Mark Crenshaw, Daniel Crimmins
There is a critical need to develop methods that capture long-term trainee outcomes and link these outcomes to interprofessional education (IPE) to establish the value added from IPE. This article describes the use of the critical incident technique (CIT) to evaluate long-term trainee outcomes attributed to IPE. Critical incidents (CIs) are specific examples of behaviours that occurred within the recent past. Trainees of an IPE programme (n = 24) were interviewed using CIT. Across the trainees, 41 CIs were reported, of which 9 were collapsed due to similarity in theme...
May 3, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28458432/rational-drug-therapy-education-in-clinical-phase-carried-out-by-task-based-learning
#14
S Sırrı Bilge, Bahar Akyüz, Arzu Erdal Ağrı, Mıdık Özlem
OBJECTIVES: Irrational drug use results in drug interactions, treatment noncompliance, and drug resistance. Rational pharmacotherapy education is being implemented in many faculties of medicine. Our aim is to introduce rational pharmacotherapy education by clinicians and to evaluate task-based rational drug therapy education in the clinical context. METHODS: The Kirkpatrick's evaluation model was used for the evaluation of the program. The participants evaluated the program in terms of constituents of the program, utilization, and contribution to learning...
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28451709/a-dosing-algorithm-for-metformin-based-on-the-relationships-between-exposure-and-renal-clearance-of-metformin-in-patients-with-varying-degrees-of-kidney-function
#15
Janna K Duong, M Y A M Kroonen, S S Kumar, H L Heerspink, C M Kirkpatrick, G G Graham, K M Williams, R O Day
PURPOSE: The aims of this study were to investigate the relationship between metformin exposure, renal clearance (CLR), and apparent non-renal clearance of metformin (CLNR/F) in patients with varying degrees of kidney function and to develop dosing recommendations. METHODS: Plasma and urine samples were collected from three studies consisting of patients with varying degrees of kidney function (creatinine clearance, CLCR; range, 14-112 mL/min). A population pharmacokinetic model was built (NONMEM) in which the oral availability (F) was fixed to 0...
April 28, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28444459/some-of-the-earliest-depictions-of-the-human-spine-a-glimpse-into-european-history
#16
EDITORIAL
Peter C Oakes, Christina Kirkpatrick, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: Drawings of the human form have a history almost as old as mankind itself. However, illustrations of the human spine as seen with the vertebral column were not seen until much later. This paper reviews some of the early European depictions of the human vertebral column from the twelfth (e.g., Fünfbilderserie "Bone-Man": 1152 A.D.) and thirteenth (e.g., Ashmole 1292) centuries. Man's understanding of his body has evolved over hundreds of years. CONCLUSIONS: This glimpse into our past and early drawings of the human spine illustrate how this particular anatomical structure was perceived almost a millennium ago and would not be structurally correct renditions until Leonardo da Vinci in the fifteenth century...
April 25, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28444240/non-specific-effects-of-oral-polio-vaccine-on-diarrheal-burden-and-etiology-among-bangladeshi-infants
#17
Alexander Upfill-Brown, Mami Taniuchi, James A Platts-Mills, Beth Kirkpatrick, Stacey L Burgess, M Steven Oberste, William Weldon, Eric Houpt, Rashidul Haque, K Zaman, William A Petri
Background: As the global polio eradication initiative prepares to cease use of oral polio vaccine (OPV) in 2020, there is increasing interest in understanding if oral vaccination provides non-specific immunity to other infections so that the consequences of this transition can be effectively planned for and mitigated. Methods: Data was collected from infants in an urban slum in Bangladesh (Mirpur, Dhaka) as part of the PROVIDE study. Following vaccination with tOPV at 6,10, and 14 weeks, infants were randomly assigned to receive tOPV (n=315) or IPV (n=299) at 39 weeks...
April 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28433961/harnessing-the-medical-humanities-for-experiential-learning
#18
Satendra Singh, Purnima Barua, Upreet Dhaliwal, Navjeevan Singh
A month-long workshop on medical humanities was held in the Jorhat Medical College, Assam in September 2015. It employed experiential learning (both online and onsite) using humanities tools, such as the theatre of the oppressed, art, literature, reflective narratives, movies, the history of medicine, graphic medicine, poetry and diversity studies. As a result of the interactions, 28 volunteer participants, comprising students and faculty members, wrote reflective narratives on doctor​-patient relationships, produced a newsletter and a logo for their medical humanities group, and staged cultural performances and forum theatre...
March 29, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28430251/development-of-an-x-ray-eight-image-kirkpatrick-baez-diagnostic-system-for-china-s-laser-fusion-facility
#19
Yaran Li, Baozhong Mu, Qing Xie, Yanan He, Zhiqiang Chen, Zhanshan Wang, Zhurong Cao, Jianjun Dong, Shenye Liu, Yongkun Ding
This article presents the development of an x-ray eight-image Kirkpatrick-Baez diagnostic system to be used at China's Shenguang-III (SG-III) laser facility in aspects of the optical design, multilayers, and online/offline tests. Six pieces of concave spherical substrates are used for constituting a special optical structure. Dual-periodic tungsten/carbon (W/C) multilayers are used for high reflectivity and large angular bandwidth of ∼0.1°. The global spatial resolution is ∼5  μm in the ±100  μm range...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28428906/tbc1d24-mutations-in-a-sibship-with-multifocal-polymyoclonus
#20
Adeline Ngoh, Jose Bras, Rita Guerreiro, Amy McTague, Joanne Ng, Esther Meyer, W Kling Chong, Stewart Boyd, Linda MacLellan, Martin Kirkpatrick, Manju A Kurian
BACKGROUND: Advances in molecular genetic technologies have improved our understanding of genetic causes of rare neurological disorders with features of myoclonus. CASE REPORT: A family with two affected siblings, presenting with multifocal polymyoclonus and neurodevelopmental delay, was recruited for whole-exome sequencing following unyielding diagnostic neurometabolic investigations. Compound heterozygous mutations in TBC1D24, a gene previously associated with various epilepsy phenotypes and hearing loss, were identified in both siblings...
2017: Tremor and Other Hyperkinetic Movements
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