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https://www.readbyqxmd.com/read/28905874/ovarian-hormones-and-transdermal-nicotine-administration-independently-and-synergistically-suppress-tobacco-withdrawal-symptoms-and-smoking-reinstatement-in-the-human-laboratory
#1
Raina D Pang, Madalyn M Liautaud, Matthew G Kirkpatrick, Jimi Huh, John Monterosso, Adam M Leventhal
Modeling intra-individual fluctuations in estradiol and progesterone may provide unique insight into the effects of ovarian hormones on the etiology and treatment of nicotine dependence. This randomized placebo-controlled laboratory study tested the independent and interactive effects of intra-individual ovarian hormone variation and nicotine on suppression of tobacco withdrawal symptoms and smoking behavior. Female smokers randomized to 21 mg. nicotine (TNP; n=37) or placebo (PBO; n=43) transdermal patch following overnight abstinence completed three sessions occurring during hormonally distinct menstrual cycle phases...
September 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28900481/routine-pre-treatment-mri-for-breast-cancer-in-a-single-payer-medical-center-effects-on-surgical-choices-timing-and-outcomes
#2
Timothy J Vreeland, John S Berry Iv, Erika Schneble, Doreen O Jackson, Garth S Herbert, Diane F Hale, Jonathon M Martin, Madeline Flores, Adam R Pattyn, Kai Hata, Guy T Clifton, Aaron D Kirkpatrick, George E Peoples
Introduction: Pre-operative MRI is being used with increasing frequency to evaluate breast cancer patients, but the debate surrounding risks and benefits of this use continues. At our institution, we instituted a standardized protocol for pre-operative MRI. Here, we compare patients seen prior to routine use of MRI to those seen after and examine effects on surgical choices, timing and outcomes. Methods: This is a retrospective review of a prospectively collected database of all new invasive breast cancers seen from January 2007 to December 2012...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28899962/pollen-aperture-factor-inp1-acts-late-in-aperture-formation-by-excluding-specific-membrane-domains-from-exine-deposition
#3
Anna A Dobritsa, Andrew B Kirkpatrick, Sarah H Reeder, Peng Li, Heather A Owen
Accurate placement of extracellular materials is a critical part of cellular development. To study how cells achieve this accuracy, we use formation of pollen apertures as a model. In Arabidopsis, three regions on the pollen surface lack deposition of pollen wall exine and develop into apertures. In developing pollen, INP1 protein acts as a marker for the pre-aperture domains, assembling there into three punctate lines. To understand the mechanism of aperture formation, we studied the dynamics of INP1 expression and localization and its relationship with the membrane domains at which it assembles...
September 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28890927/analysis-of-six-reviews-on-the-quality-of-instruments-for-the-evaluation-of-interprofessional-education-in-german-speaking-countries
#4
Jan P Ehlers, Sylvia Kaap-Fröhlich, Cornelia Mahler, Theresa Scherer, Marion Huber
Background: More and more institutions worldwide and in German-speaking countries are developing and establishing interprofessional seminars in undergraduate education of health professions. In order to evaluate the different didactic approaches and different outcomes regarding the anticipated interprofessional competencies, it is necessary to apply appropriate instruments. Cross-cultural instruments are particularly helpful for international comparability. The Interprofessional Education working group of the German Medical Association (GMA) aims at identifying existing instruments for the evaluation of interprofessional education in order to make recommendations for German-speaking countries...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28877600/technique-for-intramedullary-stabilization-of-ulnar-neck-fractures
#5
Jack Abboudi, Scott M Sandilands, C Edward Hoffler, William Kirkpatrick, William Emper
BACKGROUND: Distal ulna fractures at the ulnar neck can be seen in association with distal radius fractures, and multiple techniques have been described to address the ulnar neck component of these injuries. We have found that treatment of ulnar neck fractures can be challenging in terms of anatomy and fracture fixation. We present a new percutaneous fixation technique for ulnar neck fractures commonly seen with distal radius fractures. TECHNIQUE: Fixation of the ulnar neck fracture is performed after fixation of the distal radius fracture...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28870437/preliminary-interpretations-of-transthoracic-echocardiograms-by-cardiology-fellows
#6
Selma Carlson, Kathleen Kearney, Song Li, Michelle Fujioka, Becky Schwaegler, James N Kirkpatrick
BACKGROUND: Echocardiograms are often obtained after business hours on an urgent or emergent basis to assist in the care of patients with complex presentations. Considerable variation exists among academic medical centers with regard to who performs and interprets these studies, with different levels of cardiology fellow involvement in scanning and/or interpreting. On-call echocardiographic interpretation can be educationally valuable for cardiologists in training but may come at the expense of patient care...
September 1, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28867906/open-carpal-tunnel-release-outcomes-performed-wide-awake-versus-with-sedation
#7
Jacob E Tulipan, Nayoung Kim, Jack Abboudi, Christopher Jones, Frederic Liss, William Kirkpatrick, Michael Rivlin, Mark L Wang, Jonas Matzon, Asif M Ilyas
Background  Carpal tunnel release (CTR) is the most common surgery of the hand, and interest is growing in performing it under local anesthesia without tourniquet. To better understand differences, we hypothesized that patients undergoing CTR under wide-awake local anesthesia with no tourniquet (WALANT) versus sedation (monitored anesthesia care [MAC]) would not result in a difference in outcome. Methods  Consecutive cases of electrodiagnostically confirmed open CTR across multiple surgeons at a single center were prospectively enrolled...
August 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/28857649/immune-responses-to-oral-poliovirus-vaccine-in-hiv-exposed-uninfected-zimbabwean-infants
#8
James A Church, Sandra Rukobo, Margaret Govha, Marya P Carmolli, Sean A Diehl, Bernard Chasekwa, Robert Ntozini, Kuda Mutasa, Jean H Humphrey, Beth D Kirkpatrick, Andrew J Prendergast
It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We carried out a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe between 1997-2001, prior to introduction of prevention of mother-to-child transmission interventions. We measured poliovirus-specific IgA to type 1-3 polio strains by semi-quantitative capture ELISA in cryopreserved serum samples collected from 85 HEU and 101 HIV-unexposed infants at 6 months of age, one month after their last immunisation with trivalent OPV...
August 31, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28854199/ultrasound-2d-strain-measurement-for-arm-lymphedema-using-deformable-registration-a-feasibility-study
#9
Xiaofeng Yang, Mylin Torres, Stephanie Kirkpatrick, Walter J Curran, Tian Liu
PURPOSE: Lymphedema, a swelling of the extremity, is a debilitating morbidity of cancer treatment. Current clinical evaluation of lymphedema is often based on medical history and physical examinations, which is subjective. In this paper, the authors report an objective, quantitative 2D strain imaging approach using a hybrid deformable registration to measure soft-tissue stiffness and assess the severity of lymphedema. METHODS: The authors have developed a new 2D strain imaging method using registration of pre- and post-compression ultrasound B-mode images, which combines the statistical intensity- and structure-based similarity measures using normalized mutual information (NMI) metric and normalized sum-of-squared-differences (NSSD), with an affine-based global and B-spline-based local transformation model...
2017: PloS One
https://www.readbyqxmd.com/read/28845100/determination-of-the-enantiomeric-purity-of-epinephrine-by-hplc-with-circular-dichroism-detection
#10
Douglas Kirkpatrick, Jingyue Yang, Michael Trehy
Several hundred drug substances approved by the U.S. Food and Drug Administration are chiral molecules. For the enantiomeric purity assessment, current practice is to develop separation techniques using chiral columns or mobile phase modifiers to separate enantiomers before detection. An alternative approach is to use currently accepted HPLC assay methods and use chiral-specific detectors to confirm whether the correct enantiomer is present. In this paper, adding a circular dichroism (CD) detector to an achiral HPLC method from the US Pharmacopeia (USP) is shown to be amenable for the determination of the enantiomeric purity of epinephrine, a substance used to treat anaphylaxis...
2017: Journal of Liquid Chromatography & related Technologies
https://www.readbyqxmd.com/read/28843290/safe-return-to-driving-after-volar-plating-of-distal-radius-fractures
#11
Christopher M Jones, Randle W Ramsey, Asif Ilyas, Jack Abboudi, William Kirkpatrick, Thomas Kalina, Charles Leinberry
PURPOSE: A major concern for patients following distal radius fracture fixation is when they can resume driving. This decision has medical, legal, and safety considerations, but there are no evidence-based guidelines to assist the surgeon. The goal of this study was to observe when patients are capable of safely resuming driving following surgical fixation of the distal radius. METHODS: Patients undergoing volar plating of a distal radius fracture were prospectively enrolled...
September 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28841063/the-hope-research-community-of-practice-building-advanced-practice-nurses-research-capacity
#12
Janet Landeen, Helen Kirkpatrick, Winnifred Doyle
Background Clinical nurses have multiple challenges in conducting high-quality nursing research to inform practice. Theoretically, the development of a community of practice on nursing research centered on the concept of hope is an approach that may address some of the challenges. Purpose This article describes the delivery and evaluation of a hope research community of practice (HRCoP) approach to facilitate research expertise in a group of advanced practice nurses in one hospital. It addressed the question: Does the establishment of a HRCoP for master's prepared nurses increase their confidence and competence in leading nursing research? Method Using interpretive descriptive qualitative research methodology, five participants were interviewed about their experiences within the HRCoP and facilitators engaged in participant observation...
September 2017: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/28839040/taxonomic-resolution-of-the-nematophagous-fungal-isolate-arf18-via-genome-sequencing
#13
Sandeep Sharma, Alex Z Zaccaron, John B Ridenour, Amy Bradshaw, Terry L Kirkpatrick, Kelly Cartwright, Burton H Bluhm
The taxonomically uncharacterized nematophagous fungus ARF18, which parasitizes cysts, juveniles, and adults of the soybean cyst nematode (Heterodera glycines), was proposed as a nematode biological control agent in 1991. A 46.3-Mb draft genome sequence of this fungus is presented, and a tentative taxonomic identification as a novel species of Brachyphoris is proposed.
August 24, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28837914/what-works-in-delivering-dementia-education-or-training-to-hospital-staff-a-critical-synthesis-of-the-evidence
#14
REVIEW
Claire A Surr, Cara Gates
BACKGROUND: The quality of care delivered to people with dementia in hospital settings is of international concern. People with dementia occupy up to one quarter of acute hospital beds, however, staff working in hospitals report lack of knowledge and skills in caring for this group. There is limited evidence about the most effective approaches to training hospital staff on dementia. OBJECTIVE: The purpose of this literature review was to examine published evidence on the most effective approaches to dementia training and education for hospital staff...
August 12, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28835314/evaluation-of-skin-damage-from-accidental-removal-of-a-hemostatic-wound-clamp-the-itclamp
#15
Jessica L Mckee, Prasanna Lakshminarasimhan, Ian Atkinson, Anthony J LaPorta, Andrew W Kirkpatrick
BACKGROUND: Controlling bleeding early in the prehospital and military setting is an extremely important and life-saving skill. Wound clamping is a newly introduced technique that may augment both the effectiveness and logistics of wound packing with any gauze product. As these devices may be inadvertently removed, the potential consequences of such were examined in a simulated, extreme, inadvertent disengagement. METHODS: The wound clamp used was an iTClamp (Innovative Trauma Care; Edmonton, Alberta, Canada) that was applied and forcefully removed (skin-pull) from the skin of both a human cadaver and swine...
August 24, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28828034/splenic-trauma-wses-classification-and-guidelines-for-adult-and-pediatric-patients
#16
REVIEW
Federico Coccolini, Giulia Montori, Fausto Catena, Yoram Kluger, Walter Biffl, Ernest E Moore, Viktor Reva, Camilla Bing, Miklosh Bala, Paola Fugazzola, Hany Bahouth, Ingo Marzi, George Velmahos, Rao Ivatury, Kjetil Soreide, Tal Horer, Richard Ten Broek, Bruno M Pereira, Gustavo P Fraga, Kenji Inaba, Joseph Kashuk, Neil Parry, Peter T Masiakos, Konstantinos S Mylonas, Andrew Kirkpatrick, Fikri Abu-Zidan, Carlos Augusto Gomes, Simone Vasilij Benatti, Noel Naidoo, Francesco Salvetti, Stefano Maccatrozzo, Vanni Agnoletti, Emiliano Gamberini, Leonardo Solaini, Antonio Costanzo, Andrea Celotti, Matteo Tomasoni, Vladimir Khokha, Catherine Arvieux, Lena Napolitano, Lauri Handolin, Michele Pisano, Stefano Magnone, David A Spain, Marc de Moya, Kimberly A Davis, Nicola De Angelis, Ari Leppaniemi, Paula Ferrada, Rifat Latifi, David Costa Navarro, Yashuiro Otomo, Raul Coimbra, Ronald V Maier, Frederick Moore, Sandro Rizoli, Boris Sakakushev, Joseph M Galante, Osvaldo Chiara, Stefania Cimbanassi, Alain Chichom Mefire, Dieter Weber, Marco Ceresoli, Andrew B Peitzman, Liban Wehlie, Massimo Sartelli, Salomone Di Saverio, Luca Ansaloni
Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic derangement, and the associated injuries. The management of splenic trauma patients aims to restore the homeostasis and the normal physiopathology especially considering the modern tools for bleeding management. Thus, the management of splenic trauma should be ultimately multidisciplinary and based on the physiology of the patient, the anatomy of the injury, and the associated lesions...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28827718/broadly-protective-murine-monoclonal-antibodies-against-influenza-b-virus-target-highly-conserved-neuraminidase-epitopes
#17
Teddy John Wohlbold, Kira A Podolsky, Veronika Chromikova, Ericka Kirkpatrick, Veronica Falconieri, Philip Meade, Fatima Amanat, Jessica Tan, Benjamin R tenOever, Gene S Tan, Sriram Subramaniam, Peter Palese, Florian Krammer
A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant receptor binding protein, haemagglutinin. While broadly cross-reactive, protective monoclonal antibodies against the haemagglutinin of influenza B viruses have been described, none targeting the neuraminidase, the second most abundant viral glycoprotein, have been reported. Here, we analyse a panel of five murine anti-neuraminidase monoclonal antibodies that demonstrate broad binding, neuraminidase inhibition, in vitro antibody-dependent cell-mediated cytotoxicity and in vivo protection against influenza B viruses belonging to both haemagglutinin lineages and spanning over 70 years of antigenic drift...
August 21, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28817432/the-problems-with-burnout-research
#18
Jodie Eckleberry-Hunt, Heather Kirkpatrick, Thomas Barbera
Burnout among physicians and physicians-in-training is well established as a potential threat to the health and well-being of health care providers and patients. However, there are myriad problems with current burnout research and its ongoing measurement that threaten the validity of the conclusions. For example, researchers have used differing ways of defining and measuring burnout. Those who have used the Maslach Burnout Inventory vary in recommended use of the instrument and cutoff scores. As a result, the authors suggest that the term "burnout" may be misused and recommend some reconsideration of the meaning of burnout...
August 16, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28814969/the-role-of-open-abdomen-in-non-trauma-patient-wses-consensus-paper
#19
REVIEW
Federico Coccolini, Giulia Montori, Marco Ceresoli, Fausto Catena, Ernest E Moore, Rao Ivatury, Walter Biffl, Andrew Peitzman, Raul Coimbra, Sandro Rizoli, Yoram Kluger, Fikri M Abu-Zidan, Massimo Sartelli, Marc De Moya, George Velmahos, Gustavo Pereira Fraga, Bruno M Pereira, Ari Leppaniemi, Marja A Boermeester, Andrew W Kirkpatrick, Ron Maier, Miklosh Bala, Boris Sakakushev, Vladimir Khokha, Manu Malbrain, Vanni Agnoletti, Ignacio Martin-Loeches, Michael Sugrue, Salomone Di Saverio, Ewen Griffiths, Kjetil Soreide, John E Mazuski, Addison K May, Philippe Montravers, Rita Maria Melotti, Michele Pisano, Francesco Salvetti, Gianmariano Marchesi, Tino M Valetti, Thomas Scalea, Osvaldo Chiara, Jeffry L Kashuk, Luca Ansaloni
The open abdomen (OA) is defined as intentional decision to leave the fascial edges of the abdomen un-approximated after laparotomy (laparostomy). The abdominal contents are potentially exposed and therefore must be protected with a temporary coverage, which is referred to as temporal abdominal closure (TAC). OA use remains widely debated with many specific details deserving detailed assessment and clarification. To date, in patients with intra-abdominal emergencies, the OA has not been formally endorsed for routine utilization; although, utilization is seemingly increasing...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28807706/the-relationship-between-psychological-symptoms-and-ventricular-assist-device-implantation
#20
Himali Weerahandi, Nathan Goldstein, Laura P Gelfman, Ulrich Jorde, James N Kirkpatrick, Edith Meyerson, Judith Marble, Yoshifumi Naka, Sean Pinney, Mark S Slaughter, Emilia Bagiella, Deborah D Ascheim
CONTEXT: Ventricular assist devices (VADs) improve quality of life in advanced heart failure (HF) patients, but there are little data exploring psychological symptoms in this population. OBJECTIVE: This study examined the prevalence of psychiatric symptoms and disease over time in VAD patients. METHODS: This prospective multicenter cohort study enrolled patients immediately before or after VAD implant and followed them up to forty-eight weeks...
August 11, 2017: Journal of Pain and Symptom Management
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