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https://www.readbyqxmd.com/read/28430251/development-of-an-x-ray-eight-image-kirkpatrick-baez-diagnostic-system-for-china-s-laser-fusion-facility
#1
Yaran Li, Baozhong Mu, Qing Xie, Yanan He, Zhiqiang Chen, Zhanshan Wang, Zhurong Cao, Jianjun Dong, Shenye Liu, Yongkun Ding
This article presents the development of an x-ray eight-image Kirkpatrick-Baez diagnostic system to be used at China's Shenguang-III (SG-III) laser facility in aspects of the optical design, multilayers, and online/offline tests. Six pieces of concave spherical substrates are used for constituting a special optical structure. Dual-periodic tungsten/carbon (W/C) multilayers are used for high reflectivity and large angular bandwidth of ∼0.1°. The global spatial resolution is ∼5  μm in the ±100  μm range...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28428906/tbc1d24-mutations-in-a-sibship-with-multifocal-polymyoclonus
#2
Adeline Ngoh, Jose Bras, Rita Guerreiro, Amy McTague, Joanne Ng, Esther Meyer, W Kling Chong, Stewart Boyd, Linda MacLellan, Martin Kirkpatrick, Manju A Kurian
BACKGROUND: Advances in molecular genetic technologies have improved our understanding of genetic causes of rare neurological disorders with features of myoclonus. CASE REPORT: A family with two affected siblings, presenting with multifocal polymyoclonus and neurodevelopmental delay, was recruited for whole-exome sequencing following unyielding diagnostic neurometabolic investigations. Compound heterozygous mutations in TBC1D24, a gene previously associated with various epilepsy phenotypes and hearing loss, were identified in both siblings...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28416181/a-comparison-of-a-novel-robust-decentralised-control-strategy-and-mpc-for-industrial-high-purity-high-recovery-multicomponent-distillation
#3
Isuru A Udugama, Florian Wolfenstetter, Robert Kirkpatrick, Wei Yu, Brent R Young
In this work we have developed a novel, robust practical control structure to regulate an industrial methanol distillation column. This proposed control scheme is based on a override control framework and can manage a non-key trace ethanol product impurity specification while maintaining high product recovery. For comparison purposes, a MPC with a discrete process model (based on step tests) was also developed and tested. The results from process disturbance testing shows that, both the MPC and the proposed controller were capable of maintaining both the trace level ethanol specification in the distillate (XD) and high product recovery (β)...
April 14, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28408766/family-dis-advantage-and-life-course-expectations
#4
Monica Kirkpatrick Johnson, Steven Hitlin
Optimistic assessments of life chances can positively influence life outcomes, but conflicting theories suggest these assessments either reflect structural privilege or develop as a result of childhood hardship. In addition, competing hypotheses suggest that these assessments may matter differently depending on who holds them. We examine whether family socioeconomic status shapes adolescents' expectations about how successful their lives will turn out. We distinguish generalized life expectations (GLE), capturing anticipated success in life across multiple domains, from intergenerational comparative expectations (ICE), which register expectations about improvement relative to observed success within the respondent's family lineage...
March 2017: Social Forces; a Scientific Medium of Social Study and Interpretation
https://www.readbyqxmd.com/read/28408545/reducing-medical-admissions-into-hospital-through-optimising-medicines-remain-home-study-protocol-for-a-stepped-wedge-cluster-randomised-trial
#5
Holly Foot, Christopher Freeman, Karla Hemming, Ian Scott, Ian D Coombes, Ian D Williams, Luke Connelly, Jennifer A Whitty, Nancy Sturman, Sue Kirsa, Caroline Nicholson, Grant Russell, Carl Kirkpatrick, Neil Cottrell
INTRODUCTION: A model of general practitioner (GP) and pharmacist collaboration in primary care may be an effective strategy to reduce medication-related problems and provide better support to patients after discharge. The aim of this study is to investigate whether a model of structured pharmacist and GP care reduces hospital readmissions in high-risk patients. METHODS AND ANALYSIS: This protocol details a stepped-wedge, cluster-randomised trial that will recruit participants over 9 months with a 12-month follow-up...
April 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28406227/50-nm-resolution-full-field-x-ray-microscope-without-chromatic-aberration-using-total-reflection-imaging-mirrors
#6
Satoshi Matsuyama, Shuhei Yasuda, Jumpei Yamada, Hiromi Okada, Yoshiki Kohmura, Makina Yabashi, Tetsuya Ishikawa, Kazuto Yamauchi
X-ray spectromicroscopy with a full-field imaging technique is a powerful method for chemical analysis of heterogeneous complex materials with a nano-scale spatial resolution. For imaging optics, an X-ray reflective optical system has excellent capabilities with highly efficient, achromatic, and long-working-distance properties. An advanced Kirkpatrick-Baez geometry that combines four independent mirrors with elliptic and hyperbolic shapes in both horizontal and vertical directions was developed for this purpose, although the complexity of the system has a limited applicable range...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28396611/familial-transmission-of-educational-plans-and-the-academic-self-concept-a-three-generation-longitudinal-study
#7
Jeylan T Mortimer, Lei Zhang, Chen-Yu Wu, Jeanette Hussemann, Monica Kirkpatrick Johnson
This research investigates the social reproduction of inequality by drawing on prospective longitudinal data from three generations of Youth Development Study respondents. It examines intergenerational influence on the relatively unexplored academic self-concept as well as educational plans, a critical component of the status attainment model. A structural equation model, based on 422 3-generation triads, finds evidence that the sources giving rise to the development of children's (Generation 3) achievement orientations do not only result from parental (G2) contemporaneous influence...
March 2017: Social Psychology Quarterly
https://www.readbyqxmd.com/read/28390649/abbreviated-closure-for-remote-damage-control-laparotomy-in-extreme-environments-a-randomized-trial-of-sutures-versus-wound-clamps-comparing-terrestrial-and-weightless-conditions
#8
Andrew W Kirkpatrick, Jessica Lynn McKee, Colonel Homer Tien, Anthony J LaPorta, Kit Lavell, Tim Leslie, Paul B McBeth, Derek J Roberts, Chad G Ball
INTRODUCTION: Far-Forward Damage Control Laparotomies (DCLs) might provide direct-compression of visceral hemorrhage, however, suturing is a limiting factor, especially for non-physicians. We thus compared abbreviated skin closures comparing skin-suture (SS) versus wound-clamp (WC), on-board a research aircraft in weightlessness (0g) and normal gravity (1g). METHODS: Surgeons conducted DCLs on a surgical-simulator; onboard the hangered-aircraft (1g), or during parabolic flight (0g), randomized to either WC or SS...
March 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28385306/detection-of-atherosclerotic-inflammation-by-68-ga-dotatate-pet-compared-to-18-f-fdg-pet-imaging
#9
Jason M Tarkin, Francis R Joshi, Nicholas R Evans, Mohammed M Chowdhury, Nichola L Figg, Aarti V Shah, Lakshi T Starks, Abel Martin-Garrido, Roido Manavaki, Emma Yu, Rhoda E Kuc, Luigi Grassi, Roman Kreuzhuber, Myrto A Kostadima, Mattia Frontini, Peter J Kirkpatrick, Patrick A Coughlin, Deepa Gopalan, Tim D Fryer, John R Buscombe, Ashley M Groves, Willem H Ouwehand, Martin R Bennett, Elizabeth A Warburton, Anthony P Davenport, James H F Rudd
BACKGROUND: Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([(18)F]FDG PET), [(18)F]FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover. OBJECTIVES: This study tested the efficacy of gallium-68-labeled DOTATATE ((68)Ga-DOTATATE), a somatostatin receptor subtype-2 (SST2)-binding PET tracer, for imaging atherosclerotic inflammation...
April 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28383477/the-damage-control-surgery-in-austere-environments-research-group-dcsaerg-a-dynamic-program-to-facilitate-real-time-tele-mentoring-tele-diagnosis-to-address-exsanguination-in-extreme-and-austere-environments
#10
Andrew W Kirkpatrick, Jessica McKee, Paul B McBeth, Chad G Ball, Anthony LaPorta, Timothy Broderick, Tim Leslie, David King, Heather Wright-Beatty, Jocelyn Keillor, Homer Tien
Hemorrhage is the most preventable cause of post-traumatic death. Many cases are potentially anatomically salvageable, yet remain lethal without logistics or trained personnel to deliver diagnosis or Resuscitative-surgery in austere-environments. Revolutions in technology for remote-mentoring of ultrasound and surgery may enhance capabilities to utilize the skill-sets of non-physicians. Thus, our Research-Collaborative explored remote-mentoring to empower non-physicians to address junctional and torso hemorrhage-control in Austere-environments...
April 5, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28383352/multidimensional-evaluation-of-simulation-based-course-to-enhance-prelicensure-nursing-students-clinical-skills
#11
Daniel Ochylski, Michelle Aebersold, Mary Beth Kuebric
This article describes the development of a new simulation-based course designed to remediate the clinical skills of prelicensure nursing students and the multidimensional method used to evaluate this new course. Evaluation of the course was guided by Kirkpatrick levels of training. The Quint Leveled Clinical Competency Tool was used to evaluate students' clinical competencies. Success of the course was found in 3 levels of evaluation.
April 5, 2017: Nurse Educator
https://www.readbyqxmd.com/read/28382462/adolescent-agentic-orientations-contemporaneous-family-influence-parental-biography-and-intergenerational-development
#12
Monica Kirkpatrick Johnson, Steven Hitlin
Agentic orientations developed in adolescence have been linked to better health, well-being, and achievements in the years following. This study examines longitudinal parental influences on the development of adolescent children's agentic orientations, captured by the core constructs of mastery beliefs and generalized life expectations. Drawing on multigenerational panel data from the United States (1991-2011), the study examines contemporaneous family factors, but also how parental biographies (their own transition to adulthood) and parents' own adolescent agentic orientations influence their adolescent children...
April 5, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28380634/the-radiosurgery-fractionation-quandary-single-fraction-or-hypofractionation
#13
John P Kirkpatrick, Scott G Soltys, Simon S Lo, Kathryn Beal, Dennis C Shrieve, Paul D Brown
Stereotactic radiosurgery (SRS), typically administered in a single session, is widely employed to safely, efficiently, and effectively treat small intracranial lesions. However, for large lesions or those in close proximity to critical structures, it can be difficult to obtain an acceptable balance of tumor control while avoiding damage to normal tissue when single-fraction SRS is utilized. Treating a lesion in 2 to 5 fractions of SRS (termed "hypofractionated SRS" [HF-SRS]) potentially provides the ability to treat a lesion with a total dose of radiation that provides both adequate tumor control and acceptable toxicity...
April 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28379989/genome-wide-association-analysis-in-dogs-implicates-99-loci-as-risk-variants-for-anterior-cruciate-ligament-rupture
#14
Lauren A Baker, Brian Kirkpatrick, Guilherme J M Rosa, Daniel Gianola, Bruno Valente, Julia P Sumner, Wendy Baltzer, Zhengling Hao, Emily E Binversie, Nicola Volstad, Alexander Piazza, Susannah J Sample, Peter Muir
Anterior cruciate ligament (ACL) rupture is a common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rupture of a graft repair is also common. Risk of rupture is increased in females. ACL rupture is also common in dogs. Disease prevalence exceeds 5% in several dog breeds, ~100 fold higher than human beings. We provide insight into the genetic etiology of ACL rupture by genome-wide association study (GWAS) in a high-risk breed using 98 case and 139 control Labrador Retrievers...
2017: PloS One
https://www.readbyqxmd.com/read/28379371/challenges-to-evidence-based-health-promotion-a-case-study-of-a-food-security-coalition-in-ontario-canada
#15
Samantha B Meyer, Sara S Edge, Jocelyn Beatty, Scott Leatherdale, Chris Perlman, Jennifer Dean, Paul R Ward, Sharon I Kirkpatrick
Developing the evidence base for health promotion can be challenging because interventions often have to target competing determinants of health, including social, structural, environmental and political determinants; all of which are difficult to measure and thus evaluate. Drawing on a case study of food insecurity, which refers to inadequate access to food due to financial constraints, we illustrate the challenges faced by community-based organizations in collecting data to form an evidence base for the development and evaluation of collective programmes aimed at addressing food insecurity...
March 30, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28378194/management-of-gbm-a-problem-of-local-recurrence
#16
REVIEW
John P Kirkpatrick, Nadia N Laack, Helen A Shih, Vinai Gondi
Forty years ago, adjuvant treatment of patients with GBM using fractionated radiotherapy following surgery was shown to substantially improve survival compared to surgery alone. However, even with the addition of temozolomide to radiotherapy, overall survival is quite limited and local failure remains a fundamental problem, despite multiple attempts to increase dose to the tumor target. This review presents the historical background and clinical rationale leading to the current standard of care consisting of 60 Gy total dose in 2 Gy fractions to the MRI-defined targets in younger, high performance status patients and more hypofractionated regimens in elderly and/or debilitated patients...
April 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28376519/self-report-study-of-predictors-of-physician-wellness-burnout-and-quality-of-patient-care
#17
Jodie Eckleberry-Hunt, Heather Kirkpatrick, Kanako Taku, Ronald Hunt
OBJECTIVE: The goal of this self-report study was to examine the relation of work variables, self-rated health and mental health status, and perceived social support to physician wellness, physician burnout, and quality of patient care. METHODS: We administered a demographics questionnaire, the Physician Wellness Inventory, the Maslach Burnout Inventory, and the Patient Care Scale to a random sample of full physician members of the American Academy of Family Physicians...
April 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28370653/protecting-young-children-against-skin-cancer-parental-beliefs-roles-and-regret
#18
Kyra Hamilton, Aaron Kirkpatrick, Amanda Rebar, Katherine White, Martin S Hagger
OBJECTIVE: To examine the role of parental beliefs, roles, and anticipated regret toward performing childhood sun-protective behaviours. METHODS: Parents (N = 230; 174 mothers, 56 fathers), recruited using a non-random convenience sample, of at least one child aged between 2 and 5 years completed an initial questionnaire assessing demographics and past behaviour as well as theory of planned behaviour global (attitude, subjective norm, and perceived behavioural control) and belief-based (behavioural, normative, and control beliefs) measures, role construction, and anticipated regret regarding their intention and behaviour to protect their child from the sun...
March 31, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28369929/the-plantar-calcaneal-spur-a-review-of-anatomy-histology-etiology-and-key-associations
#19
REVIEW
Joshua Kirkpatrick, Omid Yassaie, Seyed Ali Mirjalili
The plantar calcaneal spur (PCS) is a bony outgrowth from the calcaneal tuberosity and has been studied using various methods including cadavers, radiography, histology and surgery. However, there are currently a number of discrepancies in the literature regarding the anatomical relations, histological descriptions and clinical associations of PCS. Historically, authors have described the intrinsic muscles of the foot and/or the plantar fascia as attaching to the PCS. In this article we review the relationship between the PCS and surrounding soft tissues as well as examining the histology of the PCS...
March 29, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28365188/implementation-and-assessment-of-a-training-course-for-residents-in-neonatology-and-pediatric-emergency-medicine
#20
D Brossier, A Bellot, F Villedieu, L Fazilleau, J Brouard, B Guillois
BACKGROUND AND AIMS: Residents must balance patient care and the ongoing acquisition of medical knowledge. With increasing clinical responsibilities and patient overload, medical training is often left aside. In 2010, we designed and implemented a training course in neonatology and pediatric emergency medicine for residents in pediatrics, in order to improve their medical education. The course was made of didactic sessions and several simulation-based seminars for each year of residency...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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