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https://www.readbyqxmd.com/read/27919608/sacotomy-if-all-else-fails
#1
M Elkawafi, U J Kirkpatrick
No abstract text is available yet for this article.
December 2, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27917564/mind-the-gap-in-clinical-trials-a-participatory-action-analysis-with-citizen-collaborators
#2
Amy Price, Su May Liew, Jo Kirkpatrick, Jazmin Price, Taylor Lopreto, Yasmin Nelken
What are the strengths, gaps, expectations, and barriers to research engagement in clinical trials as communicated through social media? Clinical trials test treatments to provide reliable information for safety and effectiveness. Trials are building blocks in which what is learned in earlier research can be used to improve treatments, compare alternatives, and improve quality of life. For 20 years, the percentages of clinical trials volunteers have decreased whereas the costs of running clinical trials have multiplied...
December 4, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27915265/the-ethics-of-unilateral-implantable-cardioverter-defibrillators-and-cardiac-resynchronization-therapy-with-defibrillator-deactivation-patient-perspectives
#3
Margaret Daeschler, Ralph J Verdino, James N Kirkpatrick
AIMS: Decisions about deactivation of implantable cardioverter defibrillators (ICDs) are complicated. Unilateral do-not-resuscitate (DNR) orders (against patient/family wishes) have been ethically justified in cases of medical futility. Unilateral deactivation of ICDs may be seen as a logical extension of a unilateral DNR order. However, the ethical implications of unilateral ICD deactivation have not been explored. METHODS AND RESULTS: Sixty patients who had an ICD or cardiac resynchronization therapy with defibrillator (CRT-D) were interviewed at a quaternary medical centre outpatient electrophysiology practice...
December 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27914629/cytoplasmic-fmr1-interacting-protein-2-is-a-major-genetic-factor-underlying-binge-eating
#4
Stacey L Kirkpatrick, Lisa R Goldberg, Neema Yazdani, R Keith Babbs, Jiayi Wu, Eric R Reed, David F Jenkins, Amanda F Bolgioni, Kelsey I Landaverde, Kimberly P Luttik, Karen S Mitchell, Vivek Kumar, W Evan Johnson, Megan K Mulligan, Pietro Cottone, Camron D Bryant
BACKGROUND: Eating disorders are lethal and heritable; however, the underlying genetic factors are unknown. Binge eating is a highly heritable trait associated with eating disorders that is comorbid with mood and substance use disorders. Therefore, understanding its genetic basis will inform therapeutic development that could improve several comorbid neuropsychiatric conditions. METHODS: We assessed binge eating in closely related C57BL/6 mouse substrains and in an F2 cross to identify quantitative trait loci associated with binge eating...
October 25, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27910471/the-national-ignition-facility-modular-kirkpatrick-baez-microscope
#5
L A Pickworth, J Ayers, P Bell, N F Brejnholt, J G Buscho, D Bradley, T Decker, S Hau-Riege, J Kilkenny, T McCarville, T Pardini, J Vogel, C Walton
Current two-dimensional X-ray imaging at the National Ignition Facility (NIF) uses time resolved pinhole cameras with ∼10-25 μm pinholes. This method has limitations in the smallest resolvable features that can be imaged with reasonable photon statistics for inertial confinement fusion (ICF) applications. ICF sources have a broadband self-emission spectrum that causes the pinhole images obtained, through thin foil filters, to contain a similarly broadband spectrum complicating the interpretation of structure in the source...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27904633/kirkpatrick-evaluation-model-for-in-service-training-on-cardiopulmonary-resuscitation
#6
Safoura Dorri, Malekeh Akbari, Mahmoud Dorri Sedeh
BACKGROUND: There are several evaluation models that can be used to evaluate the effect of in-service training; one of them is the Kirkpatrick model. The aim of the present study is to assess the in-service training of cardiopulmonary resuscitation (CPR) for nurses based on the Kirkpatrick's model. MATERIALS AND METHODS: This study is a cross-sectional study based on the Kirkpatrick's model in which the efficacy of in-service training of CPR to nurses was assessed in the Shahadaye Lenjan Hospital in Isfahan province in 2014...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27902434/interaction-and-signalling-networks-a-report-from-the-fourth-young-microbiologists-symposium-on-microbe-signalling-organisation-and-pathogenesis
#7
Clare L Kirkpatrick, Oliver Lesouhaitier, Jacob G Malone, Shi-Qi An, Delphine L Caly
No abstract text is available yet for this article.
November 23, 2016: Microbiology
https://www.readbyqxmd.com/read/27898952/frequency-of-leukochimerism-in-holstein-and-jersey-twinsets
#8
A S Young, B W Kirkpatrick
The current study was conducted to test breed difference in the frequency of leukochimerism. This study used leukochimerism as evidence of placental vascular anastomosis formation and compared its frequency in the Holstein and Jersey breeds. We test the null hypothesis that there is no difference in incidence of leukochimerism in the Holstein and Jersey breeds. Hair and blood samples were collected from 85 Jersey twinsets and 80 Holstein twinsets, ranging in age from 1 d to 8 yr. An additional 7 Holstein twinsets (6 complete and 1 partial where 1 twin died) were sampled originally 48 to 72 h after birth and resampled at 5 to 10 mo of age to provide an assessment of whether leukochimerism changed with age...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27892978/estimating-survival-in-patients-with-lung-cancer-and-brain-metastases-an-update-of-the-graded-prognostic-assessment-for-lung-cancer-using-molecular-markers-lung-molgpa
#9
Paul W Sperduto, T Jonathan Yang, Kathryn Beal, Hubert Pan, Paul D Brown, Ananta Bangdiwala, Ryan Shanley, Norman Yeh, Laurie E Gaspar, Steve Braunstein, Penny Sneed, John Boyle, John P Kirkpatrick, Kimberley S Mak, Helen A Shih, Alex Engelman, David Roberge, Nils D Arvold, Brian Alexander, Mark M Awad, Joseph Contessa, Veronica Chiang, John Hardie, Daniel Ma, Emil Lou, William Sperduto, Minesh P Mehta
Importance: Lung cancer is the leading cause of cancer-related mortality in the United States and worldwide. As systemic therapies improve, patients with lung cancer live longer and thus are at increased risk for brain metastases. Understanding how prognosis varies across this heterogeneous patient population is essential to individualize care and design future clinical trials. Objective: To update the current Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) for patients with non-small-cell lung cancer (NSCLC) and brain metastases...
November 17, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27890305/capacity-building-for-critical-care-training-delivery-development-and-evaluation-of-the-network-for-improving-critical-care-skills-training-nicst-programme-in-sri-lanka
#10
Tim Stephens, A Pubudu De Silva, Abi Beane, John Welch, Chathurani Sigera, Sunil De Alwis, Priyantha Athapattu, Dilantha Dharmagunawardene, Lalitha Peiris, Somalatha Siriwardana, Ashoka Abeynayaka, Kosala Saroj Amarasena Jayasinghe, Palitha G Mahipala, Arjen Dondorp, Rashan Haniffa
OBJECTIVES: To deliver and evaluate a short critical care nurse training course whilst simultaneously building local training capacity. RESEARCH METHODOLOGY: A multi-modal short course for critical care nursing skills was delivered in seven training blocks, from 06/2013-11/2014. Each training block included a Train the Trainer programme. The project was evaluated using Kirkpatrick's Hierarchy of Learning. There was a graded hand over of responsibility for course delivery from overseas to local faculty between 2013 and 2014...
November 24, 2016: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/27884636/an-in-vitro-and-in-vivo-study-of-peptide-functionalized-nanoparticles-for-brain-targeting-the-importance-of-selective-blood-brain-barrier-uptake
#11
Gerard H Bode, Gregory Coué, Christian Freese, Karin E Pickl, Maria Sanchez-Purrà, Berta Albaiges, Salvador Borrós, Ewoud C van Winden, Leto-Aikaterini Tziveleka, Zili Sideratou, Johan F Engbersen, Smriti Singh, Krystyna Albrecht, Jürgen Groll, Martin Möller, Andy J G Pötgens, Christoph Schmitz, Eleonore Fröhlich, Christian Grandfils, Frank M Sinner, C James Kirkpatrick, Harry W M Steinbusch, Hans-Georg Frank, Ronald E Unger, Pilar Martinez-Martinez
Targeted delivery of drugs across endothelial barriers remains a formidable challenge, especially in the case of the brain, where the blood-brain barrier severely limits entry of drugs into the central nervous system. Nanoparticle-mediated transport of peptide/protein-based drugs across endothelial barriers shows great potential as a therapeutic strategy in a wide variety of diseases. Functionalizing nanoparticles with peptides allows for more efficient targeting to specific organs. We have evaluated the hemocompatibilty, cytotoxicity, endothelial uptake, efficacy of delivery and safety of liposome, hyperbranched polyester, poly(glycidol) and acrylamide-based nanoparticles functionalized with peptides targeting brain endothelial receptors, in vitro and in vivo...
November 21, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27871125/eye-of-the-finch-characterization-of-the-ocular-microbiome-of-house-finches-in-relation-to-mycoplasmal-conjunctivitis
#12
Courtney A Thomason, Ariel Leon, Laila T Kirkpatrick, Lisa K Belden, Dana M Hawley
Vertebrate ocular microbiomes are poorly characterized and virtually unexplored in wildlife species. Pathogen defense is considered a key function of microbiomes, but determining microbiome stability during disease is critical for understanding the role of resident microbial communities in infectious disease dynamics. Here, we characterize the ocular bacterial microbiome of house finches (Haemorhous mexicanus), prior to and during experimental infection with an inflammatory ocular disease, Mycoplasmal conjunctivitis, caused by Mycoplasma gallisepticum...
November 21, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27869630/a-prospective-evaluation-of-opioid-utilization-after-upper-extremity-surgical-procedures-identifying-consumption-patterns-and-determining-prescribing-guidelines
#13
REVIEW
Nayoung Kim, Jonas L Matzon, Jack Abboudi, Christopher Jones, William Kirkpatrick, Charles F Leinberry, Frederic E Liss, Kevin F Lutsky, Mark L Wang, Mitchell Maltenfort, Asif M Ilyas
BACKGROUND: Although adequate management of postoperative pain with oral analgesics is an important aspect of surgical procedures, inadvertent overprescribing can lead to excess availability of opioids in the community for potential diversion. The purpose of our study was to prospectively evaluate opioid consumption following outpatient upper-extremity surgical procedures to determine opioid utilization patterns and to develop prescribing guidelines. METHODS: All patients undergoing outpatient upper-extremity surgical procedures over a consecutive 6-month period had the following prospective data collected: patient demographic characteristics, surgical details, anesthesia type, and opioid prescription and consumption patterns...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27867839/reward-contrast-effects-on-impulsive-choice-and-timing-in-rats
#14
Aaron P Smith, Jennifer R Peterson, Kimberly Kirkpatrick
Despite considerable interest in impulsive choice as a predictor of a variety of maladaptive behaviors, the mechanisms that drive choice behavior are still poorly understood. The present study sought to examine the influence of one understudied variable, reward magnitude contrast, on choice and timing behavior as changes in magnitude commonly occur within choice procedures. In addition, assessments of indirect effects on choice behavior through magnitude-timing interactions were assessed by measuring timing within the choice task...
2016: Timing & Time Perception (Leiden, Netherlands)
https://www.readbyqxmd.com/read/27857265/interdisciplinary-pain-education-moving-from-discipline-specific-to-collaborative-practice
#15
Bansari Patel, Eileen Hacker, Catherine M Murks, Catherine J Ryan
BACKGROUND: Pain is a common symptom reported by hospitalized patients with cancer. Cancer pain management requires an interdisciplinary approach for quality patient care. Although the literature suggests that most cancer pain can be managed with available treatments, many patients continue to experience pain even with opioid prescriptions. Implementation of evidence-based guidelines, such as the National Comprehensive Cancer Network's guidelines for adult cancer pain, promotes collaboration across disciplines and enhances patient care...
December 1, 2016: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/27852328/a-pilot-program-of-knowledge-translation-and-implementation-for-newborn-resuscitation-using-us-peace-corps-volunteers-in-rural-madagascar
#16
Kristin Close, Michele Karel, Michelle White
BACKGROUND: Prevention of adverse perinatal outcome using the Helping Babies Breathe (HBB) neonatal resuscitation algorithm can reduce perinatal mortality in low income settings. Mercy Ships is a non-governmental organisation providing free healthcare education in sub-Saharan Africa and in an attempt to reach more rural areas of Madagascar with our neonatal resuscitation training we designed a novel approach in collaboration with US Peace Corps Volunteers (PCV). PCVs work in rural areas and contribute to locally determined public health initiatives...
November 16, 2016: Globalization and Health
https://www.readbyqxmd.com/read/27847368/the-live-attenuated-cholera-vaccine-cvd-103-hgr-primes-responses-to-the-toxin-coregulated-pilus-antigen-tcpa-in-subjects-challenged-with-wild-type-vibrio-cholerae
#17
Leslie M Mayo-Smith, Jakub K Simon, Wilbur H Chen, Douglas Haney, Michael Lock, Caroline E Lyon, Stephen B Calderwood, Beth D Kirkpatrick, Mitchell Cohen, Myron M Levine, Marc Gurwith, Jason B Harris
One potential advantage of live attenuated bacterial vaccines is the ability to stimulate responses to antigens which are only expressed during the course of infection. To determine whether the live attenuated cholera vaccine CVD 103-HgR (Vaxchora™) results in antibody responses to the in vivo induced toxin-coregulated pilus antigen TcpA, we measured IgA and IgG responses to V. cholerae O1 El Tor TcpA in a subset of participants in a recently reported experimental challenge study. Participants were challenged with V...
November 9, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27836858/assessment-of-first-year-medical-students-perceptions-of-teaching-and-learning-through-team-based-learning-sessions
#18
Adam S Obad, Ahmed A Peeran, Mohammad Abrar Shareef, Wissal J Alsheikh, Dana A Kalagi, Abdulhadi A AlAmodi, Tehreem A Khan, Abdul Ahad Shaikh, Paul Ganguly, Ahmed Yaqinuddin
Team-based learning (TBL) is an emerging teaching and learning strategy being employed in medical schools. The College of Medicine at Alfaisal University has adopted a TBL approach as an instructional method for first-year medical students. The aim of the present study was to describe the TBL method employed at Alfaisal University College of Medicine and to assess first-year medical students' perceptions of this learning modality for the anatomy- and physiology-based blocks/courses in organ systems form of curriculum...
December 2016: Advances in Physiology Education
https://www.readbyqxmd.com/read/27831793/disaster-supply-kits
#19
Krystal Kirkpatrick
No abstract text is available yet for this article.
December 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27826006/the-effects-of-a-time-based-intervention-on-experienced-middle-aged-rats
#20
Jennifer R Peterson, Kimberly Kirkpatrick
Impulsive behavior is a common symptom in Attention Deficit Hyperactivity Disorder, schizophrenia, drug abuse, smoking, obesity and compulsive gambling. Stable levels of impulsive choice have been found in humans and rats and a recent study reported significant test-retest reliability of impulsive choice behavior after 1 and 5 months in rats. Time-based behavioral interventions have been successful in decreasing impulsive choices. These interventions led to improvements in the ability to time and respond more appropriately to adventitious choices...
December 2016: Behavioural Processes
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