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Jonas Lorenz, Mike Barbeck, Charles James Kirkpatrick, Robert Sader, Henriette Lerner, Shahram Ghanaati
PURPOSE: In this prospective study, the regenerative potential and pathways of a new injectable bone substitute (IBS) material composed of beta-tricalcium phosphate (β-TCP) and hyaluronan were investigated for its application in alveolar bone regeneration within extraction sockets. MATERIALS AND METHODS: The bone substitute material was implanted in 44 extraction sockets after removal of teeth not worth preserving in the maxillary and mandibular arches of 21 patients...
March 15, 2018: International Journal of Oral & Maxillofacial Implants
Lauren Penwell-Waines, Wendy Ward, Heather Kirkpatrick, Patrick Smith, Marwan Abouljoud
Recognizing the impact of healthcare professional (HCP) burnout has led to vigorous interest from organizations and individuals regarding how to most effectively promote HCP well-being. The present paper reviews the literature on HCP well-being and describes factors that impact well-being at various levels (i.e., system, institution, program, interpersonal, and individual). We propose that change must occur at all levels to have the greatest impact. Further, we highlight opportunities to advance research on HCP well-being (e...
March 13, 2018: Journal of Clinical Psychology in Medical Settings
Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B Desai, Nathan P Wiederhold, Annette W Fothergill, William R Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta
No abstract text is available yet for this article.
March 13, 2018: MBio
Michael T Milano, Jimm Grimm, Scott G Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A Tomé, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D Solberg, John P Kirkpatrick, Louis S Constine, John C Flickinger, Lawrence B Marks, Issam El Naqa
PURPOSE: Dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy (RION) after single-fraction stereotactic radiosurgery (SRS) or hypofractionated (2-5 fractions) radiosurgery (fSRS) were analyzed from pooled data that were extracted from published reports (PubMed indexed from 1990 to June 2015). This study was undertaken as part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy, investigating normal tissue complication probability (NTCP) after hypofractionated radiation...
January 31, 2018: International Journal of Radiation Oncology, Biology, Physics
S E Perkins-Kirkpatrick, P B Gibson
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
March 12, 2018: Scientific Reports
Kerry Wilbur, Alaa Elmubark, Sara Shabana
INTRODUCTION: The standardized patient (SP) has assumed a fundamental role in undergraduate medical education since first conceived over 50 years ago. While widely used in student training and assessment of communication and clinical examination across health disciplines, little is known how SPs enhance knowledge or skill development among professionals. We conducted a systematic review to determine the effectiveness of SPs in continuing medical education (CME) programs. METHODS: Authors independently searched for studies published between 1966 and 2016, describing CME initiatives using SP encounters as practice for participants compared with those which did not...
January 2018: Journal of Continuing Education in the Health Professions
Josyf C Mychaleckyj, Uma Nayak, E Ross Colgate, Dadong Zhang, Tommy Carstensen, Shahnawaz Ahmed, Tahmeed Ahmed, Alexander J Mentzer, Masud Alam, Beth D Kirkpatrick, Rashidul Haque, Abu Syed Golam Faruque, William A Petri
BACKGROUND: Breast milk is the sole nutrition source during exclusive breastfeeding, and polyunsaturated fatty acids (FAs) are critical micronutrients in infant physical and cognitive development. There has been no prior genomewide association study of breast milk, hence our objective was to test for genetic association with breast milk FA composition. METHODS: We measured the fractional composition of 26 individual FAs in breast milk samples from three cohorts totalling 1142 Bangladeshi mothers whose infants were genotyped on the Illumina MEGA chip and replicated on a custom Affymetrix 30K SNP array (n=616)...
March 7, 2018: Journal of Medical Genetics
Elizabeth T Rogawski, James A Platts-Mills, E Ross Colgate, Rashidul Haque, K Zaman, William A Petri, Beth D Kirkpatrick
Background: The low efficacy of rotavirus vaccines in clinical trials performed in low-resource settings may be partially explained by acquired immunity from natural exposure, especially in settings with high disease incidence. Methods: In a clinical trial of monovalent rotavirus vaccine in Bangladesh, we compared the original per-protocol efficacy estimate to efficacy derived from a recurrent events survival model in which children were considered naturally exposed and potentially immune after their first rotavirus diarrhea (RVD) episode...
March 5, 2018: Journal of Infectious Diseases
Krunal Patel, Ramez W Kirollos, Olivia Kenyon, Thomas Santarius, Peter J Kirkpatrick, Rikin A Trivedi
No abstract text is available yet for this article.
March 3, 2018: Operative Neurosurgery (Hagerstown, Md.)
Nan Xie, Nicholas Matigian, Tharindu D Vithanage, Kye Gregory, Zeyad D Nassar, Peter J Cabot, Paul Nicholas Shaw, Carl Mj Kirkpatrick, Kim-Anh Lê Cao, David Sturgess, Marie-Odile Parat
PURPOSE: To investigate the potential interplay between opioid analgesia and tumour metastasis through modulation of μ opioid receptor (MOR), Toll-like receptor 4 (TLR4) activation, and matrix degradation potential. EXPERIMENTAL DESIGN: Plasma samples were collected from 60 patients undergoing elective lower limb joint replacement pre-operatively and at 3, 6 and 24 h after surgery; pain scores were documented at the same time points. Opioid administration was recorded and converted into morphine IV equivalents...
March 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Alica Kubesch, Mike Barbeck, Sarah Al-Maawi, Anna Orlowska, Patrick F Booms, Robert A Sader, Richard J Miron, Charles J Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the relative centrifugal force (RCF) and mildly increasing the centrifugation time, resulted in modified solid and liquid PRF-matrices with increased number of platelets, leukocytes, and growth factors' concentrations...
March 6, 2018: Platelets
David A Carver, Alexsander K Bressan, Colin Schieman, Sean C Grondin, Andrew W Kirkpatrick, Rohan Lall, Paul B McBeth, Michael B Dunham, Chad G Ball
INTRODUCTION: Haemothorax following blunt thoracic trauma is a common source of morbidity and mortality. The optimal management of moderate to large haemothoraces has yet to be defined. Observational data have suggested that expectant management may be an appropriate strategy in stable patients. This study aims to compare the outcomes of patients with haemothoraces following blunt thoracic trauma treated with either chest drainage or expectant management. METHODS AND ANALYSIS: This is a single-centre, dual-arm randomised controlled trial...
March 3, 2018: BMJ Open
Amelia E Fowles, Rick D Stuart-Smith, Nicole A Hill, Russell J Thomson, Elisabeth M A Strain, Timothy J Alexander, James Kirkpatrick, Graham J Edgar
Macroalgal beds provide important habitat structure and support primary production for rocky reef communities, but are increasingly degraded as a result of human pressures. Various sources of pollution can have both direct and interactive effects on stressed ecosystems. In particular, interactions involving invertebrate grazers could potentially weaken or strengthen the overall impact of pollution on macroalgal beds. Using a paired impact-control experimental design, we tested the effects of multiple pollution sources (fish farms, marinas, sewerage, and stormwater) on translocated and locally established algal assemblages, while also considering the influence of invertebrate grazers...
March 1, 2018: Environmental Pollution
G Velkos, D S Krylov, K Kirkpatrick, X Liu, L Spree, A U B Wolter, B Büchner, H C Dorn, A A Popov
Magnetic properties of the azafullerene Gd2 @C79 N are studied by SQUID magnetometry. The effective exchange coupling constant jGd,e between the Gd spins and the spin of unpaired electron residing on the single-electron Gd-Gd bond is determined to be 170 ± 10 cm-1 . Low temperature AC measurements revealed field-induced millisecond-long relaxation of magnetization.
March 2, 2018: Chemical Communications: Chem Comm
Shuhong Luo, Harrison Hao Yang
To better prepare nurses for the new and expanding roles required in healthcare, faculty are expected to integrate emerging technology into educational processes. Using a mixed methods research design, this study aimed to examine nursing student reactions and learning based on their participation in an online research course through two technology-enhanced assignments: (1) annotation of the structure of a research article and (2) reflection on the content of a research article. Quantitative analysis examined students' questionnaire responses, and qualitative analysis explored students' reflective learning journals and the instructor's notes...
February 28, 2018: Computers, Informatics, Nursing: CIN
Julia C Dettinger, Stephen Kamau, Kimberly Calkins, Susanna R Cohen, John Cranmer, Minnie Kibore, Onesmus Gachuno, Dilys Walker
As the proportion of facility-based births increases, so does the need to ensure that mothers and their newborns receive quality care. Developing facility-oriented obstetric and neonatal training programs grounded in principles of teamwork utilizing simulation-based training for emergency response is an important strategy for improving the quality care. This study uses 3 dimensions of the Kirkpatrick Model to measure the impact of PRONTO International (PRONTO) simulation-based training as part of the Linda Afya ya Mama na Mtoto (LAMMP, Protect the Health of mother and child) in Kenya...
February 2018: Maternal & Child Nutrition
Laura P Gelfman, Marie Bakitas, Lynne Warner Stevenson, James N Kirkpatrick, Nathan E Goldstein
BACKGROUND: Heart failure (HF) is a chronic progressive illness associated with physical and psychological burdens, high morbidity, mortality, and healthcare utilization. Palliative care is interdisciplinary care that aims to relieve suffering and improve quality of life for persons with serious illness and their families. It is offered simultaneously with disease-oriented care, unlike hospice or end-of-life care. Despite the demonstrated benefits of palliative care in other populations, evidence for palliative care in the HF population is limited...
June 2017: Journal of Palliative Medicine
Julia F-M Gilmartin-Thomas, John McNeil, Anne Powell, Daniel T Malone, Rory Wolfe, Ian C Larson, Claire L O'Reilly, Carl M Kirkpatrick, Eva Kipen, Tanya Petrovich, J Simon Bell
BACKGROUND: Clinical practice guidelines for dementia highlight the importance of providing patient-centered care. This can be achieved by improving health professionals' attitudes and knowledge toward people with dementia. OBJECTIVE: Quantitatively evaluate the impact of a virtual dementia experience on medical and pharmacy students' knowledge and attitudes toward people with dementia. METHODS: A non-randomized controlled study from September-October 2016...
2018: Journal of Alzheimer's Disease: JAD
Shishi Wu, Helena Legido-Quigley, Julia Spencer, Richard James Coker, Mishal Sameer Khan
BACKGROUND: In light of the gap in evidence to inform future resource allocation decisions about healthcare provider (HCP) training in low- and middle-income countries (LMICs), and the considerable donor investments being made towards training interventions, evaluation studies that are optimally designed to inform local policy-makers are needed. The aim of our study is to understand what features of HCP training evaluation studies are important for decision-making by policy-makers in LMICs...
February 23, 2018: Health Research Policy and Systems
Karen S Moulton, Marcella Li, Keith Strand, Shawna Burgett, Penn McClatchey, Rebecca Tucker, Seth B Furgeson, Sizhao Lu, Bruce Kirkpatrick, Joseph C Cleveland, Raphael A Nemenoff, Amrut V Ambardekar, Mary Cm Weiser-Evans
Phosphatase and tensin homolog (PTEN) is an essential regulator of the differentiated vascular smooth muscle cell (SMC) phenotype. Our goal was to establish that PTEN loss promotes SMC dedifferentiation and pathological vascular remodeling in human atherosclerotic coronary arteries and nonatherosclerotic coronary arteries exposed to continuous-flow left ventricular assist devices (CF-LVADs). Arteries were categorized as nonatherosclerotic hyperplasia (NAH), atherosclerotic hyperplasia (AH), or complex plaque (CP)...
February 22, 2018: JCI Insight
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