keyword
MENU ▼
Read by QxMD icon Read
search

Kirkpatrick

keyword
https://www.readbyqxmd.com/read/28345745/in-vitro-and-in-vivo-assessment-of-the-abuse-potential-of-pf614-a-novel-bio-md%C3%A2-prodrug-of-oxycodone
#1
D Lynn Kirkpatrick, William K Schmidt, Ricardo Morales, John Cremin, Julie Seroogy, Craig Husfeld, Thomas Jenkins
OBJECTIVE: The need for pain medication which will not lead to abuse is well recognized. Ensysce has designed prodrug analogs of the commonly used pain medications including hydromorphone, oxycodone (OC), hydrocodone, and morphine that limit their use to oral delivery, two of which are in clinical development. This study was undertaken to demonstrate that PF614, an extended-release prodrug of OC, allows the release of OC as designed when delivered orally, yet it resists ex vivo extraction with household chemicals and is pharmacologically inactive when administered by nonoral routes (nasal and parenteral), thereby substantially reducing its intravenous (IV) and intranasal abuse potential...
January 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28344929/comparing-regional-precipitation-and-temperature-extremes-in-climate-model-and-reanalysis-products
#2
Oliver Angélil, Sarah Perkins-Kirkpatrick, Lisa V Alexander, Dáithí Stone, Markus G Donat, Michael Wehner, Hideo Shiogama, Andrew Ciavarella, Nikolaos Christidis
A growing field of research aims to characterise the contribution of anthropogenic emissions to the likelihood of extreme weather and climate events. These analyses can be sensitive to the shapes of the tails of simulated distributions. If tails are found to be unrealistically short or long, the anthropogenic signal emerges more or less clearly, respectively, from the noise of possible weather. Here we compare the chance of daily land-surface precipitation and near-surface temperature extremes generated by three Atmospheric Global Climate Models typically used for event attribution, with distributions from six reanalysis products...
September 2016: Weather Clim Extrem
https://www.readbyqxmd.com/read/28341610/differential-effects-of-social-and-novelty-enrichment-on-individual-differences-in-impulsivity-and-behavioral-flexibility
#3
Maya Zhe Wang, Andrew T Marshall, Kimberly Kirkpatrick
Early life experience profoundly impacts behavior and cognitive functions in rats. The present study investigated how the presence of conspecifics and/or novel objects, could independently influence individual differences in impulsivity and behavioral flexibility. Twenty-four rats were reared in an isolated condition, an isolated condition with a novel object, a pair-housed social condition, or a pair-housed social condition with a novel object. The rats were then tested on an impulsive choice task, a behavioral flexibility task, and an impulsive action task...
March 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28328322/novel-lc-ms-ms-and-high-throughput-mass-spectrometric-assays-for-monoacylglycerol-acyltransferase-inhibitors
#4
Jenson Qi, John A Masucci, Wensheng Lang, Margery A Connelly, Gary W Caldwell, Ioanna Petrounia, Jennifer Kirkpatrick, Alexander N Barnakov, Geoffrey Struble, Robyn Miller, Keli Dzordzorine, Gee-Hong Kuo, Michael Gaul, Alessandro Pocai, Seunghun Lee
Monoacylglycerol acyltransferase enzymes (MGAT1, MGAT2, and MGAT3) convert monoacylglycerol to diacylglycerol (DAG). MGAT1 and MGAT2 are both implicated in obesity-related metabolic diseases. Conventional MGAT enzyme assays use radioactive substrates, wherein the product of the MGAT-catalyzed reaction is usually resolved by time-consuming thin layer chromatography (TLC) analysis. Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG)...
April 2017: SLAS Discov
https://www.readbyqxmd.com/read/28324162/reduction-of-relative-centrifugal-forces-increases-growth-factor-release-within-solid-platelet-rich-fibrin-prf-based-matrices-a-proof-of-concept-of-lscc-low-speed-centrifugation-concept
#5
K El Bagdadi, A Kubesch, X Yu, S Al-Maawi, A Orlowska, A Dias, P Booms, E Dohle, R Sader, C J Kirkpatrick, J Choukroun, S Ghanaati
Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to assess the platelet distribution pattern within three PRF matrices. The growth factor release was measured over 10 days using ELISA. Results The VEGF protein content showed the highest release on day 7; A-PRF+ showed a significantly higher rate than A-PRF and PRF...
March 21, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28318310/comparison-of-maxim-and-sedia-limiting-antigen-assay-performance-for-measuring-hiv-incidence
#6
Katherine E Schlusser, Jacob Konikoff, Allison R Kirkpatrick, Charles Morrison, Tsungai Chipato, Pai-Lien Chen, Marshall Munjoma, Susan H Eshleman, Oliver Laeyendecker
Accurate methods for cross-sectional incidence estimation are needed for HIV prevention research. The Limiting Antigen Avidity (LAg-Avidity) assay has been marketed by two vendors, Maxim Biomedical and Sedia BioSciences Corporation. Performance differences between the two versions of the assay are unknown. We tested a total 1,410 treatment-naive samples with both versions of the assay. The samples came from 176 seroconverters from the Zimbabwe Hormonal Contraception and HIV Study. The correlation between the two versions of the assay was 0...
March 20, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28314762/cerebral-microhemorrhages-mechanisms-consequences-and-prevention
#7
Zoltan I Ungvari, Stefano Tarantini, Angelia C Kirkpatrick, Anna Csiszar, Calin I Prodan
The increasing prevalence of multifocal cerebral microhemorrhages (CMHs, also known as "cerebral microbleeds") is a significant, newly recognized problem in the aging population of the Western world. CMHs are associated with rupture of small intracerebral vessels and are thought to progressively impair neuronal function, potentially contributing to cognitive decline, geriatric psychiatric syndromes and gait disorders. Clinical studies show that aging and hypertension significantly increase prevalence of CMHs...
March 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28298272/self-report-dietary-assessment-tools-used-in-canadian-research-a-scoping-review
#8
REVIEW
Sharon I Kirkpatrick, Lana Vanderlee, Amanda Raffoul, Jackie Stapleton, Ilona Csizmadi, Beatrice A Boucher, Isabelle Massarelli, Isabelle Rondeau, Paula J Robson
Choosing the most appropriate dietary assessment tool for a study can be a challenge. Through a scoping review, we characterized self-report tools used to assess diet in Canada to identify patterns in tool use and to inform strategies to strengthen nutrition research. The research databases Medline, PubMed, PsycINFO, and CINAHL were used to identify Canadian studies published from 2009 to 2014 that included a self-report assessment of dietary intake. The search elicited 2358 records that were screened to identify those that reported on self-report dietary intake among nonclinical, non-Aboriginal adult populations...
March 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28293424/application-of-penalized-linear-regression-methods-to-the-selection-of-environmental-enteropathy-biomarkers
#9
Miao Lu, Jianhui Zhou, Caitlin Naylor, Beth D Kirkpatrick, Rashidul Haque, William A Petri, Jennie Z Ma
BACKGROUND: Environmental Enteropathy (EE) is a subclinical condition caused by constant fecal-oral contamination and resulting in blunting of intestinal villi and intestinal inflammation. Of primary interest in the clinical research is to evaluate the association between non-invasive EE biomarkers and malnutrition in a cohort of Bangladeshi children. The challenges are that the number of biomarkers/covariates is relatively large, and some of them are highly correlated. METHODS: Many variable selection methods are available in the literature, but which are most appropriate for EE biomarker selection remains unclear...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28292907/overcoming-catastrophic-forgetting-in-neural-networks
#10
James Kirkpatrick, Razvan Pascanu, Neil Rabinowitz, Joel Veness, Guillaume Desjardins, Andrei A Rusu, Kieran Milan, John Quan, Tiago Ramalho, Agnieszka Grabska-Barwinska, Demis Hassabis, Claudia Clopath, Dharshan Kumaran, Raia Hadsell
The ability to learn tasks in a sequential fashion is crucial to the development of artificial intelligence. Until now neural networks have not been capable of this and it has been widely thought that catastrophic forgetting is an inevitable feature of connectionist models. We show that it is possible to overcome this limitation and train networks that can maintain expertise on tasks that they have not experienced for a long time. Our approach remembers old tasks by selectively slowing down learning on the weights important for those tasks...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28291725/in-situ-operating-room-based-simulation-a-review
#11
Lily Owei, Christopher J Neylan, Raghavendra Rao, Robert C Caskey, Jon B Morris, Richard Sensenig, Ari D Brooks, Daniel T Dempsey, Noel N Williams, Joshua H Atkins, Dimitry Y Baranov, Kristoffel R Dumon
OBJECTIVE: To systematically review the literature surrounding operating room-based in situ training in surgery. METHODS: A systematic review was conducted of MEDLINE. The review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, and employed the Population, Intervention, Comparator, Outcome (PICO) structure to define inclusion/exclusion criteria. The Kirkpatrick model was used to further classify the outcome of in situ training when possible...
March 10, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28288209/contrasting-antibody-responses-to-intrasubtype-superinfection-with-crf02_ag
#12
Colleen R Courtney, Luzia Mayr, Aubin J Nanfack, Andrew N Banin, Michael Tuen, Ruimin Pan, Xunqing Jiang, Xiang-Peng Kong, Allison R Kirkpatrick, Daniel Bruno, Craig A Martens, Lydia Sykora, Stephen F Porcella, Andrew D Redd, Thomas C Quinn, Phillipe N Nyambi, Ralf Dürr
HIV superinfection describes the sequential infection of an individual with two or more unrelated HIV strains. Intersubtype superinfection has been shown to cause a broader and more potent heterologous neutralizing antibody response when compared to singly infected controls, yet the effects of intrasubtype superinfection remain controversial. Longitudinal samples were analyzed phylogenetically for pol and env regions using Next-Generation Sequencing and envelope cloning. The impact of CRF02_AG intrasubtype superinfection was assessed for heterologous neutralization and antibody binding responses...
2017: PloS One
https://www.readbyqxmd.com/read/28286376/high-mobility-group-box-1-protein-and-outcomes-in-critically-ill-surgical-patients-requiring-open-abdominal-management
#13
Michelle S Malig, Craig N Jenne, Chad G Ball, Derek J Roberts, Zhengwen Xiao, Andrew W Kirkpatrick
Background. Previous studies assessing various cytokines in the critically ill/injured have been uninformative in terms of translating to clinical care management. Animal abdominal sepsis work suggests that enhanced intraperitoneal (IP) clearance of Damage-Associated Molecular Patterns (DAMPs) improves outcome. Thus measuring the responses of DAMPs offers alternate potential insights and a representative DAMP, High Mobility Group Box-1 protein (HMGB-1), was considered. While IP biomediators are being recognized in critical illness/trauma, HMGB-1 behaviour has not been examined in open abdomen (OA) management...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28283921/new-insights-into-the-operative-network-of-faeo-an-enone-oxidoreductase-from-fragaria-x-ananassa-duch
#14
Gabriella Collu, Domenica Farci, Francesca Esposito, Francesca Pintus, Joanna Kirkpatrick, Dario Piano
The 2-methylene-furan-3-one reductase or Fragaria x ananassa Enone Oxidoreductase (FaEO) catalyses the last reductive step in the biosynthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone, a major component in the characteristic flavour of strawberries. In the present work, we describe the association between FaEO and the vacuolar membrane of strawberry fruits. Even if FaEO lacks epitopes for stable or transient membrane-interactions, it contains a calmodulin-binding region, suggesting that in vivo FaEO may be associated with the membrane via a peripheral protein complex with calmodulin...
March 11, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28282643/nab2-maintains-thymus-cellularity-with-aging-and-stress
#15
K Taraszka Hastings, Diana Elizalde, Leela Muppana, Sarah Levine, Christy M Kamel, Wendy M Ingram, Jennifer T Kirkpatrick, Chengcheng Hu, Matthew P Rausch, Amelia L Gallitano
Thymic cellularity is influenced by a variety of biological and environmental factors, such as age and stress; however, little is known about the molecular genetic mechanisms that regulate this process. Immediate early genes of the Early growth response (Egr) family have critical roles in immune function and response to environmental stress. The transcription factors, Egr1, Egr2 and Egr3, play roles in the thymus and in peripheral T-cell activation. Nab2, which binds Egrs 1, 2, and 3 as a co-regulator of transcription, also regulates peripheral T-cell activation...
March 7, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28279769/lumbar-facet-tropism-a-comprehensive-review
#16
REVIEW
Fernando Alonso, Christina M Kirkpatrick, William Jeong, Christian Fisahn, Sameera Usman, Tarush Rustagi, Marios Loukas, Jens R Chapman, Rod J Oskouian, R Shane Tubbs
Scattered reports exist in the medical literature regarding facet tropism. However, this finding has had mixed conclusions regarding its origin and impact on the normal spine. Herein, we review the anatomy, embryology, biomechanics, and pathology related to lumbar facet tropism. Facet tropism is most commonly found at L4-L5 vertebral segments and there is some evidence that this condition may lead to facet degenerative spondylolisthesis, intervertebral disc disease, and other degenerative conditions.
March 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28279369/the-devilish-details-of-cardiovascular-imaging-for-heart-failure-prevention
#17
EDITORIAL
James N Kirkpatrick, James Lee
No abstract text is available yet for this article.
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28277016/the-correlates-of-physical-activity-among-adult-m%C3%A3-tis
#18
Christopher J Ryan, Martin Cooke, Sharon I Kirkpatrick, Scott T Leatherdale, Piotr Wilk
OBJECTIVES: Métis, with a population of close to 390,000 people, are a culturally distinct and constitutionally recognized Aboriginal group in Canada that suffers from poorer overall health than non-Aboriginal Canadians. One important predictor of good health is physical activity. Guided by frameworks based on social and Aboriginal-specific determinants, we investigated the correlates of leisure-time physical activity (LTPA) and active transportation (walking) among adult Métis, with a particular focus on how culturally specific variables were associated with these two types of activity...
February 28, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28271081/qualitative-evaluation-of-digital-hand-x-rays-is-not-a-reliable-method-to-assess-bone-mineral-density
#19
Andrew J Miller, Christopher Jones, Frederick Liss, Jack Abboudi, William Kirkpatrick, Pedro Beredjiklian
BACKGROUND: The gold standard for evaluating bone mineral density is dual energy x-ray absorptiometry (DEXA). Prior studies have shown poor reliability using analog wrist X-rays in diagnosing osteoporosis. Our goal was to investigate if there was improved diagnostic value to visual assessment of digital hand X-rays in osteoporosis screening. We hypothesized that similar to analog counterparts, digital hand X-rays have poor correlation and reliability in determining bone mineral density (BMD) relative to DEXA...
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28269089/analysis-of-glottal-source-parameters-in-parkinsonian-speech
#20
Jane Hanratty, Catherine Deegan, Mary Walsh, Barry Kirkpatrick
Diagnosis and monitoring of Parkinson's disease has a number of challenges as there is no definitive biomarker despite the broad range of symptoms. Research is ongoing to produce objective measures that can either diagnose Parkinson's or act as an objective decision support tool. Recent research on speech based measures have demonstrated promising results. This study aims to investigate the characteristics of the glottal source signal in Parkinsonian speech. An experiment is conducted in which a selection of glottal parameters are tested for their ability to discriminate between healthy and Parkinsonian speech...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
keyword
keyword
56949
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"