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JOURNAL ARTICLE
Se Young Jung, Eun Bin Cho, Kyung-Do Han, Jin Hyung Jung, Yohwan Yeo, Sung Hye Kong, Dong Wook Shin, Ju-Hong Min
PURPOSE: Interest in fractures in patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) has considerably increased in the last decade. However, few studies have compared the incidence of fractures between patients with MS and NMOSD using a nationwide database. This study aimed to evaluate the differences in the risk of fracture between patients with NMOSD and MS compared to that in healthy controls using cohort data from a Korean nationwide database...
May 2023: Osteoporosis International
#22
JOURNAL ARTICLE
Laura Delgado-Ortiz, Ashley Polhemus, Alison Keogh, Norman Sutton, Werner Remmele, Clint Hansen, Felix Kluge, Basil Sharrack, Clemens Becker, Thierry Troosters, Walter Maetzler, Lynn Rochester, Anja Frei, Milo A Puhan, Judith Garcia-Aymerich
BACKGROUND: walking is crucial for an active and healthy ageing, but the perspectives of individuals living with walking impairment are still poorly understood. OBJECTIVES: to identify and synthesise evidence describing walking as experienced by adults living with mobility-impairing health conditions and to propose an empirical conceptual framework of walking experience. METHODS: we performed a systematic review and meta-ethnography of qualitative evidence, searching seven electronic databases for records that explored personal experiences of walking in individuals living with conditions of diverse aetiology...
January 8, 2023: Age and Ageing
#23
Hani Sayedin, Paul Jamieson
Urethral catheterization is one of the most common procedures in medical practice. Catheterization is not only restricted for urological purposes, but also used for many other indications. For instance, urethral catheterization could be used for intensive care unit patients, trauma and multiple fracture injuries, and advanced neurological condition e.g. multiple sclerosis. Therefore, it may be performed by both well trained and not fully trained medical professionals resulting in complications. We present an 82-year-old female presented to A&E with hematuria, abdominal pain and low catheter output drainage after recent catheter exchange by the district nurse...
December 2022: Journal of Surgical Case Reports
#24
JOURNAL ARTICLE
Kirsty Scott, Tecla Bonci, Francesca Salis, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Stefano Bertuletti, Marco Caruso, Lorenzo Chiari, Basil Sharrack, Walter Maetzler, Clemens Becker, Jeffrey M Hausdorff, Ioannis Vogiatzis, Philip Brown, Silvia Del Din, Björn Eskofier, Anisoara Paraschiv-Ionescu, Alison Keogh, Cameron Kirk, Felix Kluge, Encarna M Micó-Amigo, Arne Mueller, Isabel Neatrour, Martijn Niessen, Luca Palmerini, Henrik Sillen, David Singleton, Martin Ullrich, Beatrix Vereijken, Marcel Froehlich, Gavin Brittain, Brian Caulfield, Sarah Koch, Anne-Elie Carsin, Judith Garcia-Aymerich, Arne Kuederle, Alison Yarnall, Lynn Rochester, Andrea Cereatti, Claudia Mazzà
BACKGROUND: Measuring mobility in daily life entails dealing with confounding factors arising from multiple sources, including pathological characteristics, patient specific walking strategies, environment/context, and purpose of the task. The primary aim of this study is to propose and validate a protocol for simulating real-world gait accounting for all these factors within a single set of observations, while ensuring minimisation of participant burden and safety. METHODS: The protocol included eight motor tasks at varying speed, incline/steps, surface, path shape, cognitive demand, and included postures that may abruptly alter the participants' strategy of walking...
December 16, 2022: Journal of Neuroengineering and Rehabilitation
#25
JOURNAL ARTICLE
Kewen Shi, Shuguang Yuan, Yao Huang, Zheng Li, Chang Wang, Hong Liu, Lin Sun, Fuyou Liu, Xuejing Zhu
OBJECTIVES: Tubulointerstitial diseases is one of the common causes of renal dysfunction. Some rare pathological types are easy to be misdiagnosed and missedly diagnosed because of their low prevalence and relatively insufficient understanding, which affects the treatment and prognosis of patients. This study aims to explore clinical manifestations and pathological characteristics of several rare tubulointerstitial diseases, and therefore to improve their diagnosis and treatment. METHODS: A total of 9 363 patients diagnosed by renal biopsy in the Department of Nephrology, Second Xiangya Hospital, Central South University from November 2011 to September 2021 were selected...
October 28, 2022: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
#26
JOURNAL ARTICLE
Serap Turan
Dysosteosclerosis (DSS) refers to skeletal dysplasias that radiographically feature focal appendicular osteosclerosis with variable platyspondyly. Genetic heterogeneity is increasingly reported for the DSS phenotype and now involves mutations of SLC29A3, TNFRSF11A, TCIRG1, LRRK1, and CSF1R. Typical radiological findings are widened radiolucent long bones with thin cortices yet dense irregular metaphyses, flattened vertebral bodies, dense ribs, and multiple fractures. However, the radiographic features of DSS evolve, and the metaphyseal and/or appendicular osteosclerosis variably fades with increasing patient age, likely due to some residual osteoclast function...
November 16, 2022: Bone
#27
JOURNAL ARTICLE
A Stefanie Mikolaizak, Lynn Rochester, Walter Maetzler, Basil Sharrack, Heleen Demeyer, Claudia Mazzà, Brian Caulfield, Judith Garcia-Aymerich, Beatrix Vereijken, Valdo Arnera, Ram Miller, Paolo Piraino, Nadir Ammour, Mark Forrest Gordon, Thierry Troosters, Alison J Yarnall, Lisa Alcock, Heiko Gaßner, Jürgen Winkler, Jochen Klucken, Christian Schlenstedt, Henrik Watz, Anne-Marie Kirsten, Ioannis Vogiatzis, Nikolaos Chynkiamis, Emily Hume, Dimitrios Megaritis, Alice Nieuwboer, Pieter Ginis, Ellen Buckley, Gavin Brittain, Giancarlo Comi, Letizia Leocani, Jorunn L Helbostad, Lars Gunnar Johnsen, Kristin Taraldsen, Hubert Blain, Valérie Driss, Anja Frei, Milo A Puhan, Ashley Polhemus, Magda Bosch de Basea, Elena Gimeno, Nicholas S Hopkinson, Sara C Buttery, Jeffrey M Hausdorff, Anat Mirelman, Jordi Evers, Isabel Neatrour, David Singleton, Lars Schwickert, Clemens Becker, Carl-Philipp Jansen
BACKGROUND: The development of optimal strategies to treat impaired mobility related to ageing and chronic disease requires better ways to detect and measure it. Digital health technology, including body worn sensors, has the potential to directly and accurately capture real-world mobility. Mobilise-D consists of 34 partners from 13 countries who are working together to jointly develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes have the potential to provide a better, safer, and quicker way to assess, monitor, and predict the efficacy of new interventions on impaired mobility...
2022: PloS One
#28
JOURNAL ARTICLE
Yu Yao, Feng Gao, Yanni Wu, Xin Zhang, Jun Xu, Haiyang Du, Xintao Wang
Multiple sclerosis (MS) is a neurodegenerative disorder and an autoimmune disease. Until now, observational studies have indicated the association of bone mineral density (BMD) and fracture with the risk of MS. However, these studies indicated inconsistent findings. Until now, genome-wide association studies (GWAS) have been conducted in BMD, fracture, and MS, which provide large-scale datasets to investigate the causal association of BMD and fracture with the risk of MS using the Mendelian randomization (MR) study...
2022: Frontiers in Neurology
#29
JOURNAL ARTICLE
Yun Zhou, Lixian Zhong, Lianli Shen, Sisi Chen, Qiuting Zeng, Leizhen Lai, Shaohui Tang
Purpose: Based on a large number of systematic reviews and meta-analyses exploring the relationship between psoriasis and various health outcomes, we conducted an comprehensive analysis to assess the strength and evidence for the association between psoriasis and medical end-point ramifications in patients. Methods: We searched related meta-analyses, investigating the links between psoriasis and medical ramifications from three databases. All summary effect sizes, 95% CIs, heterogeneity, and small-study effects in the included meta-analyses were recalculated...
2022: Frontiers in Medicine
#30
Ritwik Ghosh Md, Devlina Roy, Moisés León-Ruiz, Shambaditya Das, Souvik Dubey, Julián Benito-León
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels. Patients with NMOSD tend to have other coexisting autoimmune/connective tissue diseases. However, AQP-4-antibody-positive NMOSD coexisting with ankylosing spondylitis (AS) is rare. AS is an immune-mediated disorder, a subset of axial spondyloarthropathies, which commonly manifests as chronic inflammatory back pain in young people, and it has a strong association with HLA-B27...
2022: Qatar Medical Journal
#31
JOURNAL ARTICLE
Tecla Bonci, Francesca Salis, Kirsty Scott, Lisa Alcock, Clemens Becker, Stefano Bertuletti, Ellen Buckley, Marco Caruso, Andrea Cereatti, Silvia Del Din, Eran Gazit, Clint Hansen, Jeffrey M Hausdorff, Walter Maetzler, Luca Palmerini, Lynn Rochester, Lars Schwickert, Basil Sharrack, Ioannis Vogiatzis, Claudia Mazzà
There is growing interest in the quantification of gait as part of complex motor tasks. This requires gait events (GEs) to be detected under conditions different from straight walking. This study aimed to propose and validate a new marker-based GE detection method, which is also suitable for curvilinear walking and step negotiation. The method was first tested against existing algorithms using data from healthy young adults (YA, n = 20) and then assessed in data from 10 individuals from the following five cohorts: older adults, chronic obstructive pulmonary disease, multiple sclerosis, Parkinson's disease, and proximal femur fracture...
2022: Frontiers in Bioengineering and Biotechnology
#32
JOURNAL ARTICLE
Sonia Afshariyamchlou, Michelle Ng, Asmaa Ferdjallah, Stuart J Warden, Paul Niziolek, Imranul Alam, Lynda E Polgreen, Erik A Imel, Paul Orchard, Michael J Econs
The osteopetroses are a group of rare genetic diseases caused by osteoclast dysfunction or absence. The hallmark of osteopetrosis is generalized increased bone mineral density (BMD). However, the bone is fragile and fractures are common. Autosomal recessive osteopetrosis is usually a severe disorder and often life-threatening in childhood. We present male siblings with autosomal recessive osteopetrosis due to biallelic variants in TCIRG1 who survived childhood and underwent hematopoietic stem cell transplant (HSCT) in adulthood...
June 2022: JBMR Plus
#33
JOURNAL ARTICLE
Bailey J Ross, Austin J Ross, Olivia C Lee, Timothy L Waters, McCayn M Familia, William F Sherman
This study highlights the persistent osteoporosis treatment gap following fragility fractures. Patients with multiple sclerosis sustained more primary hip fractures than controls and exhibited significantly higher rates of falls within three years post-fracture. However, multiple sclerosis (MS) patients were significantly more likely to be diagnosed with osteoporosis and treated with medications. INTRODUCTION: The purpose of this study was to compare rates of osteoporosis management, falls, and secondary fractures following primary fragility fractures among patients with MS versus matched controls...
September 2022: Osteoporosis International
#34
JOURNAL ARTICLE
David H Mai, Michael E Blackowicz, Ilya Kister, Ran Schwarzkopf
BACKGROUND: Multiple sclerosis (MS) is a neuroinflammatory disease with debilitating manifestations that may predispose patients to hip fracture and osteoarthritis, and may affect recovery from total hip arthroplasty (THA). With increased longevity of MS patients and growth in demand for arthroplasty in this population, it is important to understand outcomes of THA in patients with MS. AIM: We sought to compare outcomes of THA among persons with MS and without MS...
April 19, 2022: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
#35
REVIEW
Pablo Antonio Ureña Torres, Jean Claude Souberbielle, Martine Cohen Solal
Frequently silent until advanced stages, bone fragility associated with chronic kidney disease-mineral and bone disease (CKD-MBD) is one of the most devastating complications of CKD. Its pathophysiology includes the reduction of active vitamin D metabolites, phosphate accumulation, decreased intestinal calcium absorption, renal alpha klotho production, and elevated fibroblast growth factor 23 (FGF23) levels. Altogether, these factors contribute firstly to secondary hyperparathyroidism, and ultimately, to micro- and macrostructural bone changes, which lead to low bone mineral density and an increased risk of fracture...
March 20, 2022: Metabolites
#36
JOURNAL ARTICLE
Claudia Mazzà, Lisa Alcock, Kamiar Aminian, Clemens Becker, Stefano Bertuletti, Tecla Bonci, Philip Brown, Marina Brozgol, Ellen Buckley, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Nikolaos Chynkiamis, Fabio Ciravegna, Silvia Del Din, Björn Eskofier, Jordi Evers, Judith Garcia Aymerich, Eran Gazit, Clint Hansen, Jeffrey M Hausdorff, Jorunn L Helbostad, Hugo Hiden, Emily Hume, Anisoara Paraschiv-Ionescu, Neil Ireson, Alison Keogh, Cameron Kirk, Felix Kluge, Sarah Koch, Arne Küderle, Vitaveska Lanfranchi, Walter Maetzler, M Encarna Micó-Amigo, Arne Mueller, Isabel Neatrour, Martijn Niessen, Luca Palmerini, Lucas Pluimgraaff, Luca Reggi, Francesca Salis, Lars Schwickert, Kirsty Scott, Basil Sharrack, Henrik Sillen, David Singleton, Abolfazi Soltani, Kristin Taraldsen, Martin Ullrich, Linda Van Gelder, Beatrix Vereijken, Ioannis Vogiatzis, Elke Warmerdam, Alison Yarnall, Lynn Rochester
INTRODUCTION: Existing mobility endpoints based on functional performance, physical assessments and patient self-reporting are often affected by lack of sensitivity, limiting their utility in clinical practice. Wearable devices including inertial measurement units (IMUs) can overcome these limitations by quantifying digital mobility outcomes (DMOs) both during supervised structured assessments and in real-world conditions. The validity of IMU-based methods in the real-world, however, is still limited in patient populations...
December 2, 2021: BMJ Open
#37
REVIEW
Arnold H Menezes, Vincent C Traynelis
OBJECTIVE: Cervical kyphosis is rare in the pediatric population. It may be syndromic or acquired secondary to laminectomy, neoplasia, or trauma. Regardless, this should be avoided to prevent progressive spinal deformity and neurological deficit. Long-term follow-up is needed to evaluate fusion status, spine growth, potential instability, and neurological function. METHODS AND MATERIALS: A retrospective review of 27 children (6 months to 16 years) with cervical kyphotic deformity was performed and limited to the MRI era until 2008, to provide a long-term follow-up after which complex instrumentation was available...
February 2022: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#38
JOURNAL ARTICLE
Martha M C Elwenspoek, Joni Jackson, Rachel O'Donnell, Anthony Sinobas, Sarah Dawson, Hazel Everitt, Peter Gillett, Alastair D Hay, Deborah L Lane, Susan Mallett, Gerry Robins, Jessica C Watson, Hayley E Jones, Penny Whiting
BACKGROUND: The prevalence of coeliac disease (CD) is around 1%, but diagnosis is challenged by varied presentation and non-specific symptoms and signs. This study aimed to identify diagnostic indicators that may help identify patients at a higher risk of CD in whom further testing is warranted. METHODS: International guidance for systematic review methods were followed and the review was registered at PROSPERO (CRD42020170766). Six databases were searched until April 2021...
2021: PloS One
#39
REVIEW
Ashley Polhemus, Laura Delgado Ortiz, Gavin Brittain, Nikolaos Chynkiamis, Francesca Salis, Heiko Gaßner, Michaela Gross, Cameron Kirk, Rachele Rossanigo, Kristin Taraldsen, Diletta Balta, Sofie Breuls, Sara Buttery, Gabriela Cardenas, Christoph Endress, Julia Gugenhan, Alison Keogh, Felix Kluge, Sarah Koch, M Encarna Micó-Amigo, Corinna Nerz, Chloé Sieber, Parris Williams, Ronny Bergquist, Magda Bosch de Basea, Ellen Buckley, Clint Hansen, A Stefanie Mikolaizak, Lars Schwickert, Kirsty Scott, Sabine Stallforth, Janet van Uem, Beatrix Vereijken, Andrea Cereatti, Heleen Demeyer, Nicholas Hopkinson, Walter Maetzler, Thierry Troosters, Ioannis Vogiatzis, Alison Yarnall, Clemens Becker, Judith Garcia-Aymerich, Letizia Leocani, Claudia Mazzà, Lynn Rochester, Basil Sharrack, Anja Frei, Milo Puhan
Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture)...
October 14, 2021: NPJ Digital Medicine
#40
REVIEW
Alison Keogh, Rob Argent, Amy Anderson, Brian Caulfield, William Johnston
BACKGROUND: The World Health Organisation's global strategy for digital health emphasises the importance of patient involvement. Understanding the usability and acceptability of wearable devices is a core component of this. However, usability assessments to date have focused predominantly on healthy adults. There is a need to understand the patient perspective of wearable devices in participants with chronic health conditions. METHODS: A systematic review was conducted to identify any study design that included a usability assessment of wearable devices to measure mobility, through gait and physical activity, within five cohorts with chronic conditions (Parkinson's disease [PD], multiple sclerosis [MS], congestive heart failure, [CHF], chronic obstructive pulmonary disorder [COPD], and proximal femoral fracture [PFF])...
September 15, 2021: Journal of Neuroengineering and Rehabilitation
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