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Multiple sclerosis fracture

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https://www.readbyqxmd.com/read/29598927/epidemiology-of-hip-fracture-in-nursing-home-residents-with-multiple-sclerosis
#1
Tingting Zhang, Andrew R Zullo, Theresa I Shireman, Yoojin Lee, Vincent Mor, Qing Liu, Kevin W McConeghy, Lori Daiello, Douglas P Kiel, Sarah D Berry
BACKGROUND: Hip fracture risk is high in young people with multiple sclerosis (MS), but has not been examined in an institutionalized aging population with MS. OBJECTIVE: We aimed to compare the hip fracture risk in nursing home (NH) residents with and without MS; and (2) examine risk factors for hip fracture in those with MS. METHODS: We conducted a retrospective cohort study using national NH clinical assessment and Medicare claims data...
March 21, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29569488/structural-and-functional-properties-of-bone-are-compromised-in-amyotrophic-lateral-sclerosis-mice
#2
Frank C Ko, Jia Li, Daniel J Brooks, Seward B Rutkove, Mary L Bouxsein
In addition to muscle weakness, amyotrophic lateral sclerosis (ALS) is associated with an increased incidence of skeletal fractures. The SOD1G93A mouse model recapitulates many features of human ALS. These mice also exhibit decreased bone mass. However, the functional, or biomechanical, behavior of the skeleton in SOD1G93A mice has not been investigated. To do so, we examined skeletal phenotypes in end-stage (16-week-old) SOD1G93A female mice and healthy littermate female controls (N = 9-10/group). Outcomes included trabecular and cortical bone microarchitecture by microcomputed tomography; stiffness and strength via three-point bending; resistance to crack growth by fracture toughness testing; and cortical bone matrix properties via cyclic reference point indentation...
March 23, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29480950/reparative-bone-like-tissue-formation-in-the-tooth-of-a-systemic-sclerosis-patient
#3
S Matsuda, T Memida, N Mizuno, I Ogawa, K Ouhara, M Kajiya, T Fujita, E Sugiyama, H Kurihara
AIM: To report a case of reparative bone-like tissue formation in the tooth of a patient with systemic sclerosis. SUMMARY: A 58-year-old Japanese female patient with systemic sclerosis was referred because of tooth fracture. Cone beam computerized tomography (CBCT) revealed multiple root resorption and the unclear transition from alveolar bone to root profile. A sample from a fractured tooth was analysed histologically. Haematoxylin and eosin-stained sections revealed the irregular replacement of pulp and dentine by bone-like tissue...
February 26, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29354163/secondary-aneurysmal-bone-cyst-in-mccune-albright-syndrome
#4
Symeon Tournis, Alexia Balanika, Panayiotis D Megaloikonomos, Andreas F Mavrogenis
Polyostotic fibrous dysplasia in combination with caféau-lait macules and hyperfunctioning endocrinopathies consists of a rare clinical condition termed as McCune-Albright syndrome. Aneurysmal bone cysts are tumor-like cystic lesions, composed of blood-filled compartments. They may occur as primary lesions or secondary to other pathologies; most commonly giant cell tumors of bone. However, secondary aneurysmal bone cysts in McCune-Albright syndrome are exceptional. We present a 28-year-old female with McCune-Albright syndrome...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28660405/xanthogranulomatous-osteomyelitis-of-the-humerus-in-a-pediatric-patient-with-alagille-syndrome-a-case-report-and-literature-review
#5
Adnan Cheema, Alexandre Arkader, Bruce Pawel
Xanthogranulomatous osteomyelitis (XO) is an exceedingly rare disease characterized by infiltration of histiocytes and foamy macrophages. Both on gross examination and on radiographs, XO can mimic malignancy. We describe the case of a 5-year-old female with Alagille syndrome who presented with a pathologic fracture of the right humerus. Initial radiographs revealed multiple osteolytic lesions in the distal humerus while MRI showed a large soft tissue mass. Biopsy confirmed the diagnosis of XO, which has hitherto not been described in a patient with Alagille syndrome...
October 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28507642/diagnostic-imaging-of-pregnant-women-the-role-of-magnetic-resonance-imaging
#6
Monika Bekiesińska-Figatowska, Anna Romaniuk-Doroszewska, Sylwia Szkudlińska-Pawlak, Agnieszka Duczkowska, Jarosław Mądzik, Martyna Szopa-Krupińska, Tomasz M Maciejewski
BACKGROUND: Presentation of magnetic resonance imaging (MRI) findings in pregnant women in the Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland. MATERIAL/METHODS: Forty-three symptomatic pregnant women underwent MRI between 9 and 33 weeks of gestation (mean of 23 weeks). Moreover, we included 2 pregnant women who underwent fetal MRI and had incidental abnormalities. RESULTS: In 9 cases, we excluded the suspected brain abnormalities...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28470695/sublethal-oligodendrocyte-injury-a-reversible-condition-in-multiple-sclerosis
#7
Qiao-Ling Cui, Damla Khan, Malena Rone, Vijayaraghava T S Rao, Radia Marie Johnson, Yun Hsuan Lin, Philippe-Antoine Bilodeau, Jeffery A Hall, Moses Rodriguez, Timothy E Kennedy, Samuel K Ludwin, Jack P Antel
OBJECTIVE: Degeneration of oligodendroglial distal processes has been identified as an early event in multiple sclerosis (MS) lesion development. Our objective was to further define the development of the "dying-back" oligodendrocyte lesion in situ and to model the development and potential reversibility of such responses using dissociated cultures of adult human brain-derived oligodendrocytes. METHODS: In situ analyses were performed on glutaraldehyde-fixed thin sections of clinically acute and pathologically active cases of MS...
June 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28393275/traumatic-multiple-cervical-spine-injuries-in-a-patient-with-osteopetrosis-and-its-management
#8
Ashok Keshav Rathod, Rakesh Padmakar Dhake, Mandar Deepak Borde
STUDY DESIGN: Single case report. OBJECTIVE/PURPOSE: To report multiple level fractures of cervical spine in a patient with osteopetrosis and its management. Osteopetrosis is a rare inherited condition characterized by defective remodeling resulting in hard and brittle bones with diffuse osteosclerosis. Fractures of spine are rare as compared to the common long bone fractures. We report a case of traumatic multiple level fractures of cervical spine in osteopetrosis and its management which has rarely been reported in the literature before, if any...
May 2017: European Spine Journal
https://www.readbyqxmd.com/read/28390010/vitamin-d-supplementation-in-the-prevention-and-management-of-major-chronic-diseases-not-related-to-mineral-homeostasis-in-adults-research-for-evidence-and-a-scientific-statement-from-the-european-society-for-clinical-and-economic-aspects-of-osteoporosis-and
#9
Luisella Cianferotti, Francesco Bertoldo, Heike A Bischoff-Ferrari, Olivier Bruyere, Cyrus Cooper, Maurizio Cutolo, John A Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi
INTRODUCTION: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. PURPOSE AND METHODS: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field...
May 2017: Endocrine
https://www.readbyqxmd.com/read/28376767/high-dose-vitamin-d-supplementation-does-not-affect-biochemical-bone-markers-in-multiple-sclerosis-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Trygve Holmøy, Jonas Christoffer Lindstrøm, Erik Fink Eriksen, Linn Hofsøy Steffensen, Margitta T Kampman
BACKGROUND: People with multiple sclerosis have high risk of osteoporosis and fractures. A poor vitamin D status is a risk factor for MS, and vitamin D supplementation has been recommended both to prevent MS progression and to maintain bone health. METHODS: We assessed the effect of 20,000 IU vitamin D3 weekly compared to placebo on biochemical markers of bone metabolism in 68 persons with relapsing remitting multiple sclerosis. RESULTS: Serum levels of 25-hydroxyvitamin D more than doubled in the vitamin D group, and parathyroid hormone decreased in the vitamin D group compared to the placebo group at week 48 and week 96...
April 4, 2017: BMC Neurology
https://www.readbyqxmd.com/read/27913383/traumatic-haemopneumothorax-and-whole-body-subcutaneous-emphysema-successful-use-of-a-small-bore-chest-drain
#11
Benjamin Hardy, Nicholas Sunderland, Mevan Perera, Kathryn Channing
A 56-year-old man presented having had two falls at home. He had a background of multiple sclerosis. After his second fall, during which he had fallen onto the toilet injuring his right chest, he was brought into the emergency department reporting pleuritic chest discomfort. Immediately evident was extensive swelling from his forehead to his thighs, which on palpation was found to be subcutaneous emphysema. A chest X-ray showed a large right-sided pneumothorax for which a chest drain was inserted. A CT revealed extensive surgical emphysema, pneumomediastinum, pneumoperitoneum and gas within the spinal canal...
December 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27753744/healthy-life-years-lost-and-excess-bed-days-due-to-6-patient-safety-incidents-empirical-evidence-from-english-hospitals
#12
Katharina D Hauck, Shaolin Wang, Charles Vincent, Peter C Smith
BACKGROUND: There is little satisfactory evidence on the harm of safety incidents to patients, in terms of lost potential health and life-years. OBJECTIVE: To estimate the healthy life-years (HLYs) lost due to 6 incidents in English hospitals between the years 2005/2006 and 2009/2010, to compare burden across incidents, and estimate excess bed-days. RESEARCH DESIGN: The study used cross-sectional analysis of the medical records of all inpatients treated in 273 English hospitals...
February 2017: Medical Care
https://www.readbyqxmd.com/read/27525980/risk-factors-epidemiology-and-treatment-strategies-for-metabolic-bone-disease-in-patients-with-neurological-disease
#13
REVIEW
S Binks, R Dobson
Metabolic bone disease is a major public health concern, especially when it manifests as hip fracture which carries significant morbidity and mortality. Individuals with neurological disease are at higher risk of osteopenia, osteoporosis and fragility fracture compared to age-matched controls, yet this is under-appreciated by these patients. Clinician attention to this topic is therefore of importance and should address the bone health of men as well as women, a group in whom it may be an under-recognised problem...
October 2016: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/27375138/bone-metabolism-and-vitamin-d-status-in-patients-with-multiple-sclerosis
#14
Katarzyna Kępczyńska, Małgorzata Zajda, Zbigniew Lewandowski, Jerzy Przedlacki, Beata Zakrzewska-Pniewska
BACKGROUND: Vitamin D (VD), an important factor for bone health immobilization and immune regulation, has been shown to have low serum concentration in multiple sclerosis (MS) patients. Those patients have also multiple fracture risk factors, including progressive immobilization and long-term glucocorticoids treatment. The aim of the study was to analyze bone health (osteopenia or osteoporosis prevalence) and VD serum concentration in MS patients as well as the influence of disease activity and treatment on bone health...
July 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27362963/assessment-of-vitamin-d-status-a-changing-landscape
#15
REVIEW
Markus Herrmann, Christopher-John L Farrell, Irene Pusceddu, Neus Fabregat-Cabello, Etienne Cavalier
In recent years it has been shown that vitamin D deficiency is associated with an increased incidence as well as the progression of a broad range of diseases including osteoporosis, rickets, cardiovascular disease, autoimmune disease, multiple sclerosis and cancer. Consequently, requests for the assessment of vitamin D status have increased dramatically. Despite significant progress in the analysis of vitamin D metabolites and an expansion of our pathophysiological knowledge of vitamin D, the assessment of vitamin D status remains a challenging and partially unresolved issue...
January 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27334254/risk-of-osteoporotic-fractures-in-multiple-sclerosis-patients-in-southwest-finland
#16
J Åivo, S Kurki, M-L Sumelahti, K Hänninen, J Ruutiainen, M Soilu-Hänninen
OBJECTIVES: Increased risk of osteoporotic fractures in multiple sclerosis (MS) patients compared with general population has been reported. The purpose of this study was to assess the risk of osteoporotic and other low-energy fractures in an MS cohort from a large hospital district in southwest Finland. Age-adjusted total and gender-specific prevalence for definite MS per 100 000 in a population of 472 139 was calculated as a point prevalence in December 31, 2012. MATERIALS AND METHODS: Patients with MS and comorbid fractures were identified by searching for ICD-9 and ICD-10 codes during a period from 2004 to 2012 from hospital administrative data in Turku University Hospital (TYKS) in southwest Finland Case ascertainment was performed by review of medical records...
May 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27243346/is-disuse-osteopenia-a-favorable-prognostic-sign-after-femoral-neck-fracture
#17
MULTICENTER STUDY
Beverlie L Ting, Marilyn Heng, Mark S Vrahas, Edward K Rodriguez, Mitchel B Harris, Michael J Weaver
OBJECTIVES: Avascular necrosis (AVN) of the femoral head is a devastating complication following fixation of femoral neck fractures in younger adults. In this study, we investigate the prognostic utility of disuse osteopenia. DESIGN: Retrospective study. SETTING: Three academic Level 1 trauma centers. PATIENTS: One hundred twenty patients younger than 60 years treated for a femoral neck fracture. INTERVENTION: N/A...
September 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27063628/bone-health-in-patients-with-multiple-sclerosis-relapses
#18
Olwen Murphy, Michael S Zandi, Nitzan Lindenberg, Elaine Murphy, Jeremy Chataway
OBJECTIVES: To evaluate the bone health and vitamin D levels of a cohort of patients with relapses of multiple sclerosis (MS) and to propose an algorithm for the management of bone health in this patient group. METHODS: We prospectively studied 56 consecutive patients from our acute relapse clinic. 3 patients were excluded from analysis as they were not deemed to have experienced an acute MS relapse. Bone health was assessed with vitamin D levels and Dual Energy X-ray Absorptiometry (DEXA) scanning (10 patients failed to attend for DEXA)...
March 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27037437/exchange-nailing-for-nonunion-of-diaphyseal-fractures-of-the-tibia-our-results-and-an-analysis-of-the-risk-factors-for-failure
#19
S T J Tsang, L A Mills, J Frantzias, J P Baren, J F Keating, A H R W Simpson
AIMS: The aim of this study was to identify risk factors for the failure of exchange nailing in nonunion of tibial diaphyseal fractures. PATIENTS AND METHODS: A cohort of 102 tibial diaphyseal nonunions in 101 patients with a mean age of 36.9 years (15 to 74) were treated between January 1992 and December 2012 by exchange nailing. Of which 33 (32%) were initially open injuries. The median time from primary fixation to exchange nailing was 6.5 months (interquartile range (IQR) 4...
April 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/26951286/vitamin-d-a-narrative-review-examining-the-evidence-for-ten-beliefs
#20
REVIEW
G Michael Allan, Lynda Cranston, Adrienne Lindblad, James McCormack, Michael R Kolber, Scott Garrison, Christina Korownyk
Over the past decade, a large body of observational evidence has suggested an association between lower vitamin D status (25-hydroxyvitamin D) and multiple acute and chronic disorders, including cancer, multiple sclerosis, depression and respiratory tract infections. This evidence has fostered the hypothesis that increasing vitamin D intake may treat and prevent such disorders. Our objective was to perform a critical analysis of the highest-level evidence for ten common beliefs regarding vitamin D for the prevention of falls, fractures and respiratory tract infections, the reduction of cancer incidence/mortality and overall mortality, and the prevention or treatment of depression/mental well-being, rheumatoid arthritis and multiple sclerosis, as well as maximum dosing and regular testing...
July 2016: Journal of General Internal Medicine
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