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https://www.readbyqxmd.com/read/29762159/vitamin-d-in-inflammatory-bowel-disease-more-than-just-a-supplement
#1
John Gubatan, Alan C Moss
PURPOSE OF REVIEW: The aim of this review is to explore the protective role of vitamin D on the gastrointestinal tract, summarize the epidemiology of vitamin D deficiency in inflammatory bowel disease (IBD), and highlight recent studies examining the impact of low vitamin D and vitamin D supplementation on IBD clinical outcomes. RECENT FINDINGS: Vitamin D protects the gut barrier by regulating tight junction proteins and inhibiting intestinal apoptosis. Vitamin D enhances innate immunity by inducing antimicrobial peptides and regulates adaptive immunity by promoting anti-inflammatory T cells and cytokines...
May 11, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29751786/meconium-peritonitis-due-to-fetal-appendiceal-perforation-two-case-reports-and-a-brief-review-of-the-literature
#2
Yi Wang, Yeming Wu, Wenbin Guan, Wenbo Yan, Yuhua Li, Jin Fang, Jun Wang
BACKGROUND: Meconium peritonitis is an infrequent congenital disease usually caused by perforation of the fetal digestive tract. Meconium peritonitis resulting from intrauterine appendiceal perforation has been rarely reported and is often overlooked during pregnancy. We herein report two cases of fetal appendiceal perforation. CASE PRESENTATION: Two neonates were found to have intestinal distension and gradually increasing ascites antenatally. After birth, diagnostic abdominal punctures revealed meconium peritonitis...
May 11, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29742071/application-of-a-baseball-suture-technique-in-uterine-myomectomy-following-laparoscopic-enucleation-of-uterine-leiomyoma-fibroid
#3
Lingling Xie, Yunyun Liu, Dongyan Wang, Changhao Liu, Hui Zhou, Zhongqiu Lin, Huaiwu Lu
BACKGROUND The aim of this study was to evaluate the safety and efficacy of a 'baseball' suture technique for uterine myomectomy incision closure in laparoscopic surgical enucleation of uterine leiomyoma (fibroid). MATERIAL AND METHODS The study included 20 patients who underwent laparoscopic myomectomy with a 'baseball' suture technique, compared with 20 patients who underwent laparoscopic myomectomy with a standard suture method. Clinical characteristics, perioperative and follow-up data were compared between the two groups...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29738163/-laparoscopic-extraperitoneal-high-ligation-of-the-spermatic-vein-for-the-treatment-of-varicocele
#4
Qing-Qiang Gao, Zhi-Peng Xu, Wen Yu, Hai Chen, Tao Song, Yun Chen, Yu-Tian Dai
Objective: To investigate the effect of laparoscopic extraperitoneal (LSEP) high ligation of the spermatic vein in the treatment of varicocele. METHODS: We retrospectively analyzed the clinical data about 80 cases of varieocele, 48 treated by LSEP and the other 32 by laparoscopic transabdominal retroperitoneal (LSTR) high ligation of the spermatic vein. We recorded the semen parameters before and at 1, 3 and 6 months after surgery, intraoperative blood loss, operation time, postoperative complications, time of gastrointestinal function recovery and rate of pregnancy, followed by comparison of the data obtained between the two groups of patients...
November 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29737455/current-and-future-use-of-chloroquine-and-hydroxychloroquine-in-infectious-immune-neoplastic-and-neurological-diseases-a-mini-review
#5
REVIEW
Domenico Plantone, Tatiana Koudriavtseva
The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects...
May 8, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29735288/clinical-practice-guidelines-for-the-treatment-of-systemic-lupus-erythematosus-by-the-mexican-college-of-rheumatology
#6
Daniel Xibillé-Friedmann, Marcela Pérez-Rodríguez, Sandra Carrillo-Vázquez, Everardo Álvarez-Hernández, Francisco Javier Aceves, Mario C Ocampo-Torres, Conrado García-García, José Luis García-Figueroa, Javier Merayo-Chalico, Ana Barrera-Vargas, Margarita Portela-Hernández, Sandra Sicsik, Lilia Andrade-Ortega, Víctor Manuel Rosales-Don Pablo, Aline Martínez, Pilar Prieto-Seyffert, Mario Pérez-Cristóbal, Miguel Ángel Saavedra, Zully Castro-Colín, Azucena Ramos, Gabriela Huerta-Sil, María Fernanda Hernández-Cabrera, Luis Javier Jara, Leonardo Limón-Camacho, Lizbet Tinajero-Nieto, Leonor A Barile-Fabris
There are national and international clinical practice guidelines for systemic lupus erythematosus treatment. Nonetheless, most of them are not designed for the Mexican population or are devoted only to the treatment of certain disease manifestations, like lupus nephritis, or are designed for some physiological state like pregnancy. The Mexican College of Rheumatology aimed to create clinical practice guidelines that included the majority of the manifestations of systemic lupus erythematosus, and also incorporated guidelines in controversial situations like vaccination and the perioperative period...
May 4, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29720579/congenital-esophageal-atresia-and-microtia-in-a-newborn-secondary-to-mycophenolate-mofetil-exposure-during-pregnancy-a-case-report-and-review-of-the-literature
#7
Musaed Mohammed Alsebayel, Faisal Abdulrahman Abaalkhail, Faisal Mohammed Alsebayel, Dema A Alissa, Ahmed Hamdan Al-Jedai, Hussien Elsiesy
BACKGROUND Mycophenolate mofetil (MMF) is one of the most commonly prescribed drugs to prevent organ transplant rejection in combination with calcineurin inhibitors and steroids. It has a different toxicity profile than tacrolimus and cyclosporine.  Gastrointestinal tract disturbances are the most common adverse effects. The use of MMF in pregnant women, however, holds great risk of miscarriage and fetal development defects such as external ear malformation, ocular anomalies, cleft lip and palate, and abnormality of distal limbs, heart, esophagus, and kidneys...
May 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29712513/-express-prenatal-maternal-stress-induces-visceral-hypersensitivity-of-adult-rat-offspring-through-activation-of-cystathionine-%C3%AE-synthase-signaling-in-primary-sensory-neurons
#8
Hong-Jun Wang, Xue Xu, Rui-Hua Xie, Yun-Yun Rui, Ping-An Zhang, Xiao-Jue Zhu, Guang-Yin Xu
Irritable bowel syndrome (IBS) is a disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that stressors presented during gestational periods could have long-term effects on the offspring's tissue structure and function, which may predispose to gastrointestinal diseases. The aim of the present study is designed to determine whether prenatal maternal stress (PMS) is a adverse factor affecting gastrointestinal sensitivity and to investigate possible mechanisms underlying PMS-induced visceral hypersensitivity in adult offspring...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29707395/fetal-sirenomelia-associated-with-an-abdominal-cyst-originating-from-a-saccular-cloaca
#9
Yui Kinjo, Hitoshi Masamoto, Hayase Nitta, Tadatsugu Kinjo, Tomoko Tamaki, Naoki Yoshimi, Yoichi Aoki
A 40-year-old pregnant woman presented with a fetal abdominal cyst and oligohydramnios. Color Doppler scan revealed a single blood vessel from the fetal aorta into a single umbilical artery. Severe oligohydramnios limited ultrasonographic evaluation of the fetal lower limbs, kidneys, or bladder. The pregnancy was terminated; the fetus showed fused lower limbs, bulging abdomen, and absent external genitalia and was diagnosed with type III sirenomelia. On autopsy, no normal bladder was observed, but duodenal atresia, anorectal atresia, and right renal agenesis were found...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29703052/a-newborn-patient-with-both-annular-pancreas-and-meckel-s-diverticulum-a-case-report-of-an-unusual-association
#10
Peng Cai, Zhenwei Zhu, Jianlei Chen, Lulu Chen, Jiang Pan, Wenxian Zhi, Jie Zhu, Bin Wu, Zhicheng Gu, Shungen Huang, Jian Wang
RATIONALE: Annular pancreas (AP) is recognized as a cause of duodenal obstruction in children, while children with Meckel's diverticulum (MD) are usually asymptomatic. Here we present a rare case with both AP and MD, which was identified by abdominal exploration during diamond-shaped duodenoduodenostomy. PATIENT CONCERNS: A "double-bubble" sign was found by ultrasound at 35 week of pregnancy. After 39 weeks of pregnancy, the male patient was transferred to the Department of General Surgery, Children's Hospital of Soochow University because of a suspected duodenal stenosis...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29701043/-therapeutic-effects-on-ovulation-and-reproduction-promotion-with-acupuncture-and-clomiphene-in-polycystic-ovary-syndrome
#11
Liqing Yu, Lianying Cao, Jing Xie, Yin Shi
OBJECTIVE: To compare the difference in the therapeutic effects on ovulation disorder in polycystic ovary syndrome (PCOS) between the combined therapy of electroacupuncture and clomiphene and the single medication of clomiphene and to explore the effect mechanism. METHODS: A total of 80 patients of PCOS were randomized into an acupuncture plus medication group (40 cases) and a medication group (40 cases). In the medication group, since the 5th day of menstruation or medicine-withdrawal bleeding, clomiphene was prescribed for oral administration, continuously for 5 days...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29686912/recurrent-volvulus-during-pregnancy-case-report-and-review-of-the-literature
#12
Layan Alrahmani, Jaclyn Rivington, Carl H Rose
Introduction: Sigmoid colon volvulus (SV) represents the most common etiology of antepartum gastrointestinal obstruction, with repetitive antepartum episodes rarely reported. Case Presentation: A 25-year-old multiparous patient with history of SV at 26 weeks in her previous pregnancy presented with recurrent episodes of SV at 32 0/7, 32 4/7, 37 0/7, and 38 1/7 weeks successfully managed with colonoscopic decompression. Labor was successfully induced at 38 4/7 weeks, and she experienced two further episodes on postpartum days #1 and #32 also treated with colonoscopic decompression, followed by laparoscopic resection...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29685440/the-association-of-serum-%C3%AE-hydroxybutyrate-concentration-with-fetal-number-and-health-indicators-in-late-gestation-ewes-in-commercial-meat-flocks-in-prince-edward-island
#13
Niorn Ratanapob, John VanLeeuwen, Shawn McKenna, Maureen Wichtel, Juan C Rodriguez-Lecompte, Paula Menzies, Jeffrey Wichtel
Late-gestation ewes are susceptible to ketonemia resulting from high energy requirement for fetal growth during the last few weeks of pregnancy. High lamb mortality is a possible consequence of effects of ketonemia on both ewes and lambs. Determining risk factors to ketonemia is a fundamental step to identify ewes at risk, in order to avoid losses caused by ketonemia. Serum β-hydroxybutyrate (BHBA) concentrations of 384 late-gestation ewe samples were determined. Physical examinations, including body condition, FAMACHA© and hygiene scoring, were performed...
June 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29682369/intrahepatic-cholangiocarcinoma-masquerading-as-acute-fatty-liver-of-pregnancy-a-case-report-and-review-of-the-literature
#14
Ayman Qasrawi, Omar Abughanimeh, Mouhanna Abu Ghanimeh, Simran Arora-Elder, Osama Yousef, Tarek Tamimi
Cholangiocarcinoma (CCA) is an uncommon cancer and accounts only for 3% of all gastrointestinal malignancies. In this report, we present a case of an intrahepatic cholangiocarcinoma masquerading as acute fatty liver of pregnancy (AFLP). A 38-year-old female who is 36-week pregnant presented with a 1-week history of headache, nausea, vomiting, and right upper abdominal pain, along with hepatomegaly. Laboratory investigations were remarkable for mild leukocytosis, hyperbilirubinemia, proteinuria, and elevated transaminases and prothrombin time...
2018: Case Reports in Hepatology
https://www.readbyqxmd.com/read/29661236/clinical-analysis-of-50-patients-with-heterotopic-pregnancy-after-ovulation-induction-or-embryo-transfer
#15
Zaigui Wu, Xinmei Zhang, Ping Xu, Xiufeng Huang
OBJECTIVES: The purpose of this study was to evaluate the clinical characteristics, prenatal diagnosis, and management of patients with heterotopic pregnancy after ovulation induction or embryo transfer. METHODS: This was a retrospective study of fifty cases with heterotopic pregnancy, in which the fertilization way, type and number of embryo transferred, gestational age, clinical presentation and outcome of intrauterine, ultrasound presentation and site of ectopic pregnancy, bilateral fallopian tube and treatment were evaluated...
April 16, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29630018/prescription-and-other-medication-use-in-pregnancy
#16
David M Haas, Derek J Marsh, Danny T Dang, Corette B Parker, Deborah A Wing, Hyagriv N Simhan, William A Grobman, Brian M Mercer, Robert M Silver, Matthew K Hoffman, Samuel Parry, Jay D Iams, Steve N Caritis, Ronald J Wapner, M Sean Esplin, Michal A Elovitz, Alan M Peaceman, Judith Chung, George R Saade, Uma M Reddy
OBJECTIVE: To characterize prescription and other medication use in a geographically and ethnically diverse cohort of women in their first pregnancy. METHODS: In a prospective, longitudinal cohort study of nulliparous women followed through pregnancy from the first trimester, medication use was chronicled longitudinally throughout pregnancy. Structured questions and aids were used to capture all medications taken as well as reasons they were taken. Total counts of all medications taken including number in each category and class were captured...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29626275/antenatal-management-for-women-with-inflammatory-bowel-disease-experience-from-our-ibd-mom-clinic
#17
Ariella Bar-Gil Shitrit, Yael Cohen, Ori Hassin, Ami Ben Ya'acov, Rivkah Farkash, Benjamin Koslowsky, Yael Milgrom, Dan Meir Livovsky, Arnon Samueloff, Eran Goldin, Sorina Grisaru-Granovsky
BACKGROUND: Inflammatory bowel disease affects women during their reproductive years and thus pregnancy outcomes. IBD MOM is a multidisciplinary, single-center clinic established to benefit women with IBD and their neonates. AIM: The aim of this study was to evaluate the perinatal outcomes of the IBD MOM clinic patients compared to patients who attended antenatal and gastrointestinal disease community clinics (IBD CC). METHODS: This single-center, prospective study was conducted from 2011 to 2015...
April 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29595273/-life-threatening-manifestations-of-lupus-and-antiphospholipid-syndrome-in-internal-medicine
#18
Pavel Horák, Martina Skácelová, Jiří Vymětal, Markéta Schubertová
The clinical picture of systemic lupus and antiphospholipid syndrome is remarkably varied and disease manifestations are commonly very heterogeneous. Relatively often both diseases are associated with severe, acute and life threatening manifestations, which places demands on the knowledge of differential diagnostics and experience of the physicians. This article deals with the serious and mostly acute impairment of cardiovascular, respiratory, renal, gastrointestinal, hematopoietic or nervous systems, briefly discusses the acute pregnancy complication and summarizes the basic therapeutic option...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29590672/prenatally-diagnosed-single-umbilical-artery-sua-retrospective-analysis-of-1169-fetuses
#19
Ulrike Friebe-Hoffmann, Andreas Hiltmann, Thomas W P Friedl, Krisztian Lato, Rüdiger Hammer, Wolfgang Janni, Peter Kozlowski
PURPOSE:  The incidence of a fetal single umbilical artery (SUA) is about 0.5 % and has been associated with an increased risk of congenital malformations, fetal aneuploidy and intrauterine growth restriction (IUGR). MATERIALS AND METHODS:  A retrospective analysis of 1169 women with singleton pregnancies diagnosed with fetal SUA between 1997 and 2014 in a specialized practice for prenatal diagnostics has been performed. Data was obtained on maternal and fetal findings as well as pregnancy outcome...
March 28, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29582550/consensus-opinion-on-diagnosis-and-management-of-thrombotic-microangiopathy-in-australia-and-new-zealand
#20
REVIEW
Lucy C Fox, Solomon J Cohney, Joshua Y Kausman, Jake Shortt, Peter D Hughes, Erica M Wood, Nicole M Isbel, Theo de Malmanche, Anne Durkan, Pravin Hissaria, Piers Blombery, Thomas D Barbour
Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory to look for red cell fragments on a blood film. Whilst TMA of any aetiology generally demands prompt treatment, this is especially so in thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS), where organ failure may be precipitous, irreversible and fatal...
March 27, 2018: Internal Medicine Journal
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