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Pediatric acute onset neuropsychiatric syndrome

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https://www.readbyqxmd.com/read/27370066/-evaluation-of-a-neuropsychiatric-disorder-from-pandas-to-pans-and-cans
#1
Muharrem Burak Baytunca, Tuğba Donuk, Serpil Erermiş
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder seen before adolescence that possesses an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. Swedo and colleagues defined this disorder in 1998 as a syndrome related to Group A streptoccoccus (GAS) infection with neurological issues, such as motor hyperactivation and choreiform movements. The progress of the disorder may be described as wax-and-waning, apart from abrupt onset, and this relapse and remission course is associated with exacerbating infections, according to the creators of PANDAS syndrome...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27166296/rapid-eye-movement-sleep-abnormalities-in-children-with-pediatric-acute-onset-neuropsychiatric-syndrome-pans
#2
Thomas Gaughan, Ashura Buckley, Rebecca Hommer, Paul Grant, Kyle Williams, James F Leckman, Susan E Swedo
STUDY OBJECTIVES: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. RESULTS: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep...
July 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26988046/complete-genome-sequence-of-emm4-streptococcus-pyogenes-mew427-a-throat-isolate-from-a-child-meeting-clinical-criteria-for-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcus-pandas
#3
Kristin M Jacob, Theodore Spilker, John J LiPuma, Suzanne R Dawid, Michael E Watson
We report the complete genome assembly of the Streptococcus pyogenes type emm4 strain MEW427 (also referred to as strain UM001 in the Pediatric Acute-Onset Neuropsychiatric Syndrome [PANS] Research Consortium), a throat isolate from a child with acute-onset neuropsychiatric symptoms meeting clinical criteria for PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus). The genome length is 1,814,455 bp with 38.51% G+C%.
2016: Genome Announcements
https://www.readbyqxmd.com/read/25978743/a-pilot-trial-of-cognitive-behavioral-therapy-augmentation-of-antibiotic-treatment-in-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-related-obsessive-compulsive-disorder
#4
Joshua M Nadeau, Cary Jordan, Robert R Selles, Monica S Wu, Morgan A King, Priyal D Patel, Camille E Hanks, Elysse B Arnold, Adam B Lewin, Tanya K Murphy, Eric A Storch
BACKGROUND: This study reports an open trial of family-based cognitive-behavioral therapy (CBT) in children and adolescents with obsessive-compulsive disorder (OCD) exhibiting an onset pattern consistent with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Eleven primarily Caucasian youth with PANS-related OCD (range=4-14 years; 6 boys) who were incomplete responders to antibiotic treatment, received family-based CBT delivered either face-to-face or via web camera...
May 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25929634/ophelia-syndrome-hodgkin-lymphoma-with-limbic-encephalitis
#5
Monica Juneja, Satnam Kaur, Devendra Mishra, Silky Jain
BACKGROUND: Limbic encephalitis, an immune-mediated encephalitis, results from inflammation in the medial temporal lobes. The paraneoplastic form is rare in pediatric population, and frequently precedes tumor diagnosis. CASE CHARACTERISTICS: A 9-year-old boy receiving chemotherapy for Hodgkin lymphoma, developed headache, temporal lobe seizures, anxiety, hallucinations, short-term memory loss and autonomic disturbances. Magnetic resonance imaging of brain showed features suggestive of limbic encephalitis...
April 2015: Indian Pediatrics
https://www.readbyqxmd.com/read/25816440/is-it-pans-cans-or-pandas-neuropsychiatric-pediatric-disorders-that-are-not-black-and-white-implications-for-the-school-nurse
#6
Kathy Bagian, Sheila Q Hartung
The terms pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), pediatric acute-onset neuropsychiatric syndrome (PANS), and childhood acute neuropsychiatric symptoms (CANS) have all been used to describe certain acute onset neuropsychiatric pediatric disorders. Additionally, controversy is ongoing concerning the diagnosis and etiology of the disorders. The school nurse, as a member of a multidisciplinary team, benefits from an awareness of these disorders, the resulting impact on school performance, and the recommended treatment...
March 2015: NASN School Nurse
https://www.readbyqxmd.com/read/25695943/multidisciplinary-clinic-dedicated-to-treating-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-presenting-characteristics-of-the-first-47-consecutive-patients
#7
Jennifer Frankovich, Margo Thienemann, Jennifer Pearlstein, Amber Crable, Kayla Brown, Kiki Chang
BACKGROUND: Abrupt, dramatic onset obsessive-compulsive disorder (OCD) and/or eating restriction with at least two coinciding symptoms (anxiety, mood dysregulation, irritability/aggression/oppositionality, behavioral regression, cognitive deterioration, sensory or motor abnormalities, or somatic symptoms) defines pediatric acute-onset neuropsychiatric syndrome (PANS). Descriptions of clinical data in such youth are limited. METHODS: We reviewed charts of 53 consecutive patients evaluated in our PANS Clinic; 47 met PANS symptom criteria but not all met the requirement for "acute onset...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25695942/five-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-of-differing-etiologies
#8
Jennifer Frankovich, Margo Thienemann, Sonal Rana, Kiki Chang
BACKGROUND: Pediatric acute-onset neuropsychiatric syndrome (PANS) is diagnosed by the abrupt onset of new obsessive compulsive disorder (OCD) or food-restricting symptoms, and at least two of a variety of other neuropsychiatric symptoms. Detailed clinical presentation of youth with this condition has not yet been provided in the literature. METHODS: We review the clinical charts of five youth meeting criteria for PANS in our PANS Clinic. These five patients were selected for differing underlying causes thought to be driving an inflammatory response that appeared to impact psychiatric symptoms...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25695941/clinical-presentation-of-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections-in-research-and-community-settings
#9
MULTICENTER STUDY
Susan E Swedo, Jakob Seidlitz, Miro Kovacevic, M Elizabeth Latimer, Rebecca Hommer, Lorraine Lougee, Paul Grant
BACKGROUND: The first cases of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) were described >15 years ago. Since that time, the literature has been divided between studies that successfully demonstrate an etiologic relationship between Group A streptococcal (GAS) infections and childhood-onset obsessive-compulsive disorder (OCD), and those that fail to find an association. One possible explanation for the conflicting reports is that the diagnostic criteria proposed for PANDAS are not specific enough to describe a unique and homogeneous cohort of patients...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25695940/special-issue-on-pediatric-acute-onset-neuropsychiatric-syndrome
#10
Kiki Chang, Harold S Koplewicz, Ron Steingard
No abstract text is available yet for this article.
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25344730/cytokine-profiles-by-peripheral-blood-monocytes-are-associated-with-changes-in-behavioral-symptoms-following-immune-insults-in-a-subset-of-asd-subjects-an-inflammatory-subtype
#11
Harumi Jyonouchi, Lee Geng, Amy L Davidow
BACKGROUND: Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (ASD-IS) for this study. We reported a high prevalence of non-IgE mediated food allergy (NFA) in young ASD children before, but not all ASD/NFA children reveal such clinical features of ASD-IS...
2014: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25329522/disordered-eating-and-food-restrictions-in-children-with-pandas-pans
#12
Megan D Toufexis, Rebecca Hommer, Diana M Gerardi, Paul Grant, Leah Rothschild, Precilla D'Souza, Kyle Williams, James Leckman, Susan E Swedo, Tanya K Murphy
OBJECTIVE: Sudden onset clinically significant eating restrictions are a defining feature of the clinical presentation of some of the cases of pediatric acute-onset neuropsychiatric syndrome (PANS). Restrictions in food intake are typically fueled by contamination fears; fears of choking, vomiting, or swallowing; and/or sensory issues, such as texture, taste, or olfactory concerns. However, body image distortions may also be present. We investigate the clinical presentation of PANS disordered eating and compare it with that of other eating disorders...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25325534/clinical-evaluation-of-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-pans-recommendations-from-the-2013-pans-consensus-conference
#13
Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W Cunningham, M Elizabeth Latimer, Tanya K Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, Susan E Swedo
On May 23 and 24, 2013, the First PANS Consensus Conference was convened at Stanford University, calling together a geographically diverse group of clinicians and researchers from complementary fields of pediatrics: General and developmental pediatrics, infectious diseases, immunology, rheumatology, neurology, and child psychiatry. Participants were academicians with clinical and research interests in pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS) in youth, and the larger category of pediatric acute-onset neuropsychiatric syndrome (PANS)...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25314221/characterization-of-the-pediatric-acute-onset-neuropsychiatric-syndrome-phenotype
#14
Tanya K Murphy, Priyal D Patel, Joseph F McGuire, Allison Kennel, P Jane Mutch, E Carla Parker-Athill, Camille E Hanks, Adam B Lewin, Eric A Storch, Megan D Toufexis, Gul H Dadlani, Carina A Rodriguez
OBJECTIVE: Pediatric acute-onset neuropsychiatric syndrome (PANS) is a subtype of obsessive compulsive disorder (OCD) marked by an abrupt onset or exacerbation of neuropsychiatric symptoms. We aim to characterize the phenotypic presentation of youth with PANS. METHODS: Forty-three youth (ages 4-14 years) meeting criteria for PANS were assessed using self-report and clinician-administered measures, medical record reviews, comprehensive clinical evaluation, and laboratory measures...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25309889/no-cases-of-pandas-on-follow-up-of-patients-referred-to-a-pediatric-movement-disorders-clinic
#15
Sarah Kilbertus, Renee Brannan, Erick Sell, Asif Doja
INTRODUCTION: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) remains a controversial diagnosis and it is unclear how frequently it is encountered in clinical practice. Our study aimed to determine how many children with acute-onset tics and/or Obsessive-Compulsive Disorder (OCD) met criteria for PANDAS. MATERIALS AND METHODS: A retrospective review was performed on 39 children who presented to a movement disorders clinic with acute-onset tics or OCD from 2005 to 2012...
2014: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/25150567/pediatric-acute-onset-neuropsychiatric-syndrome
#16
REVIEW
Tanya K Murphy, Diana M Gerardi, James F Leckman
Whether some instances of obsessive-compulsive disorder are secondary to infectious and/or autoimmune processes is still under scientific debate. The nosology has undergone an iterative process of criteria and acronyms from PITANDS to PANDAS to PANS (or CANS for neurology). This review focuses on the clinical presentation, assessment, proposed pathophysiology, and treatment of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS), and the newest iteration, pediatric acute-onset neuropsychiatric syndrome (PANS)...
September 2014: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/24922491/obsessive-compulsive-disorder-in-youth-assessment-and-treatment
#17
REVIEW
Jennifer G Wells
For pediatric patients with obsessive-compulsive disorder, clinicians must address particular diagnostic and treatment challenges. Children with obsessive-compulsive disorder may have little insight into their obsessions and compulsions, requiring clinicians to provide age-appropriate education, motivation, and therapy. Treatment should take into account children's developmental level, family accommodation, and comorbidities. If the onset of obsessive-compulsive disorder is sudden, clinicians may use pediatric acute-onset neuropsychiatric syndrome criteria and conduct appropriate tests...
May 2014: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/24891915/a-new-clinical-feature-associated-with-familial-early-onset-of-dystonic-guttural-tics-an-unusual-diagnosis-of-pandas
#18
Giovanna Vitaliti, Rosario R Trifiletti, Raffaele Falsaperla, Enrico Parano, Alberto Spalice, Piero Pavone
Until today there is a large debate about the existence of PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) or PANS (pediatric acute onset neuropsychiatric syndrome). These children usually have dramatic, "overnight" onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions. In addition to these symptoms, children may also have comorbid features of associated disorders. Herein, we report a family with an early onset of tics, with exclusively dystonic and guttural tics...
January 2014: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/24106651/pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections-pandas-an-evolving-concept
#19
Antonella Macerollo, Davide Martino
Pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections (PANDAS) originated from the observational work of Swedo and collaborators, who formalized their definition in 1998 in a set of operational criteria. The application of these criteria, which focuses on tics and obsessive-compulsive symptoms as core symptoms, has encountered difficulties, eventually leading to a high rate of misdiagnosis. In particular, the core feature represented by the association between newly diagnosed infections and neuropsychiatric symptom relapses in youths with this diagnosis could not be demonstrated by longitudinal studies...
2013: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/23918895/a-case-report-of-obsessive-compulsive-disorder-following-acute-disseminated-encephalomyelitis
#20
Katherine E Muir, Katherine S McKenney, Mary B Connolly, S Evelyn Stewart
We present a case of a boy who developed obsessive-compulsive disorder (OCD) shortly after an episode of acute disseminated encephalomyelitis (ADEM). To our knowledge, this is the first report of the development of OCD in a child who has had ADEM. This presentation is consistent with our understanding of OCD as a complex genetic disease involving the cerebral white matter tracts, and may indicate a potential pathway for the development of OCD in genetically vulnerable individuals or a shared trigger for the development of pediatric acute-onset neuropsychiatric syndrome and ADEM...
September 2013: Pediatrics
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