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Pediatric acute onset neuropsychiatric syndrome

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https://www.readbyqxmd.com/read/28538981/association-of-streptococcal-throat-infection-with-mental-disorders-testing-key-aspects-of-the-pandas-hypothesis-in-a-nationwide-study
#1
Sonja Orlovska, Claus Høstrup Vestergaard, Bodil Hammer Bech, Merete Nordentoft, Mogens Vestergaard, Michael Eriksen Benros
Importance: Streptococcal infection has been linked with the development of obsessive-compulsive disorder (OCD) and tic disorders, a concept termed pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). However, previous studies of this association have been small, and the results have been conflicting. Objective: To investigate the risk of mental disorders, specifically OCD and tic disorders, after a streptococcal throat infection...
May 24, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28498087/an-expert-opinion-on-pandas-pans-highlights-and-controversies
#2
Francesca Chiarello, Silvia Spitoni, Eric Hollander, Marco Matucci Cerinic, Stefano Pallanti
OBJECTIVES: 'Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections' (PANDAS) identified a unique subgroup of patients with abrupt onset of obsessive compulsive disorder (OCD) symptoms clinically related to Streptococcus infection and accompanied by neuropsychological and motor symptoms. After almost 20 years, PANDAS has not been accepted as distinct disorder and new criteria for paediatric acute-onset neuropsychiatric syndrome (PANS) have been replaced it, highlighting the fact that several agents rather than only Streptococcus might be involved...
June 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28422636/impact-of-pans-and-pandas-exacerbations-on-occupational-performance-a-mixed-methods-study
#3
Janice Trigilio Tona, Sutanuka Bhattacharjya, Denise Calaprice
OBJECTIVE: Pediatric acute-onset neuropsychiatric syndrome (PANS) includes pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and involves sudden-onset neuropsychiatric symptoms, including obsessions, compulsions, sensory difficulties, and dysgraphia after infection or other triggers. Our objective was to identify problems with areas of occupation, body functions, and performance skills during exacerbations. METHOD: In this online retrospective study, based on the Occupational Therapy Practice Framework: Domain and Process (2nd ed...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28387528/palatal-petechiae-in-the-absence-of-group-a-streptococcus-in-pediatric-patients-with-acute-onset-neuropsychiatric-deterioration-a-cohort-study
#4
Talia Mahony, Douglas Sidell, Hayley Gans, Michael Cooperstock, Kayla Brown, Joanne M Cheung, Bahare Farhadian, Melissa Gustafson, Margo Thienemann, Jennifer Frankovich
BACKGROUND: Palatal petechiae are 95% specific for streptococcal pharyngitis. Despite this, and despite prior research demonstrating that Group A Streptococcus (GAS) is a common antecedent to pediatric acute-onset neuropsychiatric syndrome (PANS) episodes, we anecdotally observed a low rate of documented GAS in patients with PANS and palatal petechiae. This retrospective chart review was conducted to formally report the rate of palatal petechiae and concurrent GAS in a cohort of patients with PANS and investigate other etiologic factors...
April 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28358599/a-double-blind-randomized-placebo-controlled-pilot-study-of-azithromycin-in-youth-with-acute-onset-obsessive-compulsive-disorder
#5
Tanya K Murphy, Erin M Brennan, Carly Johnco, Ellisa Carla Parker-Athill, Branko Miladinovic, Eric A Storch, Adam B Lewin
OBJECTIVES: Sudden and severe onset of obsessive-compulsive disorder (OCD) may present secondary to infectious and/or immune-mediated triggers. We assessed the preliminary efficacy, tolerability, and safety of azithromycin compared with placebo in the treatment of OCD and associated symptoms in children with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Thirty-one youth aged 4-14 years (M = 8.26 ± 2.78 years, 62.5% male) were randomized to receive either placebo or azithromycin for 4 weeks (10 mg/kg up to 500 mg per day)...
March 30, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28140619/a-survey-of-pediatric-acute-onset-neuropsychiatric-syndrome-characteristics-and-course
#6
Denise Calaprice, Janice Tona, Ellisa Carla Parker-Athill, Tanya K Murphy
OBJECTIVE: To date, studies in the area of pediatric acute-onset neuropsychiatric syndrome (PANS; including pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection [PANDAS] and pediatric infection-triggered neuropsychiatric disorder [PITAND]) have been relatively small and hence unable to comprehensively address questions of disease heterogeneity (e.g., by age, gender), comorbidities, and progression. In this study, we investigated an internet survey sample to more fully characterize the phenotypic traits; medical, family, and developmental history; functional challenges; and clinical course associated with PANS...
January 31, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28121463/prevalence-of-acute-onset-subtypes-in-pediatric-obsessive-compulsive-disorder
#7
Fern Jaspers-Fayer, Sang Hun Jerry Han, Elaine Chan, Katherine McKenney, Annie Simpson, Andrea Boyle, Rhonda Ellwyn, S Evelyn Stewart
BACKGROUND: Pediatric obsessive-compulsive disorder (OCD) is a common, debilitating illness. When childhood OCD symptom onset is described as acute and severe, diagnostic criteria for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) should be considered. However, the frequency and differentiating features of these putative syndromes within pediatric OCD remain poorly understood...
May 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28012531/improvement-of-psychiatric-symptoms-in-youth-following-resolution-of-sinusitis
#8
Talia Mahony, Douglas Sidell, Hayley Gans, Kayla Brown, Bahare Farhadian, Melissa Gustafson, Janell Sherr, Margo Thienemann, Jennifer Frankovich
INTRODUCTION: Accumulating evidence supports a role for inflammation in psychiatric illness, and the onset or exacerbation of psychiatric symptoms may follow non-CNS infections. Here, we provide the first detailed description of obsessive-compulsive and related psychiatric symptoms arising concurrently with sinusitis. METHODS: We reviewed the charts of 150 consecutive patients evaluated in our Pediatric Acute-onset Neuropsychiatric Syndromes clinic for documented sinusitis as defined by the American Academy of Pediatrics guidelines...
January 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27370066/-evaluation-of-a-neuropsychiatric-disorder-from-pandas-to-pans-and-cans
#9
Muharrem Burak Baytunca, Tuğba Donuk, Serpil Erermiş
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder seen before adolescence that possesses an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. Swedo and colleagues defined this disorder in 1998 as a syndrome related to Group A streptoccoccus (GAS) infection with neurological issues, such as motor hyperactivation and choreiform movements. The progress of the disorder may be described as wax-and-waning, apart from abrupt onset, and this relapse and remission course is associated with exacerbating infections, according to the creators of PANDAS syndrome...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27166296/rapid-eye-movement-sleep-abnormalities-in-children-with-pediatric-acute-onset-neuropsychiatric-syndrome-pans
#10
Thomas Gaughan, Ashura Buckley, Rebecca Hommer, Paul Grant, Kyle Williams, James F Leckman, Susan E Swedo
STUDY OBJECTIVES: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. RESULTS: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep...
July 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/26988046/complete-genome-sequence-of-emm4-streptococcus-pyogenes-mew427-a-throat-isolate-from-a-child-meeting-clinical-criteria-for-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcus-pandas
#11
Kristin M Jacob, Theodore Spilker, John J LiPuma, Suzanne R Dawid, Michael E Watson
We report the complete genome assembly of the Streptococcus pyogenes type emm4 strain MEW427 (also referred to as strain UM001 in the Pediatric Acute-Onset Neuropsychiatric Syndrome [PANS] Research Consortium), a throat isolate from a child with acute-onset neuropsychiatric symptoms meeting clinical criteria for PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus). The genome length is 1,814,455 bp with 38.51% G+C%.
March 17, 2016: Genome Announcements
https://www.readbyqxmd.com/read/25978743/a-pilot-trial-of-cognitive-behavioral-therapy-augmentation-of-antibiotic-treatment-in-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-related-obsessive-compulsive-disorder
#12
Joshua M Nadeau, Cary Jordan, Robert R Selles, Monica S Wu, Morgan A King, Priyal D Patel, Camille E Hanks, Elysse B Arnold, Adam B Lewin, Tanya K Murphy, Eric A Storch
BACKGROUND: This study reports an open trial of family-based cognitive-behavioral therapy (CBT) in children and adolescents with obsessive-compulsive disorder (OCD) exhibiting an onset pattern consistent with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Eleven primarily Caucasian youth with PANS-related OCD (range=4-14 years; 6 boys) who were incomplete responders to antibiotic treatment, received family-based CBT delivered either face-to-face or via web camera...
May 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25929634/ophelia-syndrome-hodgkin-lymphoma-with-limbic-encephalitis
#13
Monica Juneja, Satnam Kaur, Devendra Mishra, Silky Jain
BACKGROUND: Limbic encephalitis, an immune-mediated encephalitis, results from inflammation in the medial temporal lobes. The paraneoplastic form is rare in pediatric population, and frequently precedes tumor diagnosis. CASE CHARACTERISTICS: A 9-year-old boy receiving chemotherapy for Hodgkin lymphoma, developed headache, temporal lobe seizures, anxiety, hallucinations, short-term memory loss and autonomic disturbances. Magnetic resonance imaging of brain showed features suggestive of limbic encephalitis...
April 2015: Indian Pediatrics
https://www.readbyqxmd.com/read/25816440/is-it-pans-cans-or-pandas-neuropsychiatric-pediatric-disorders-that-are-not-black-and-white-implications-for-the-school-nurse
#14
Kathy Bagian, Sheila Q Hartung
The terms pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), pediatric acute-onset neuropsychiatric syndrome (PANS), and childhood acute neuropsychiatric symptoms (CANS) have all been used to describe certain acute onset neuropsychiatric pediatric disorders. Additionally, controversy is ongoing concerning the diagnosis and etiology of the disorders. The school nurse, as a member of a multidisciplinary team, benefits from an awareness of these disorders, the resulting impact on school performance, and the recommended treatment...
March 2015: NASN School Nurse
https://www.readbyqxmd.com/read/25695943/multidisciplinary-clinic-dedicated-to-treating-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-presenting-characteristics-of-the-first-47-consecutive-patients
#15
Jennifer Frankovich, Margo Thienemann, Jennifer Pearlstein, Amber Crable, Kayla Brown, Kiki Chang
BACKGROUND: Abrupt, dramatic onset obsessive-compulsive disorder (OCD) and/or eating restriction with at least two coinciding symptoms (anxiety, mood dysregulation, irritability/aggression/oppositionality, behavioral regression, cognitive deterioration, sensory or motor abnormalities, or somatic symptoms) defines pediatric acute-onset neuropsychiatric syndrome (PANS). Descriptions of clinical data in such youth are limited. METHODS: We reviewed charts of 53 consecutive patients evaluated in our PANS Clinic; 47 met PANS symptom criteria but not all met the requirement for "acute onset...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25695942/five-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-of-differing-etiologies
#16
Jennifer Frankovich, Margo Thienemann, Sonal Rana, Kiki Chang
BACKGROUND: Pediatric acute-onset neuropsychiatric syndrome (PANS) is diagnosed by the abrupt onset of new obsessive compulsive disorder (OCD) or food-restricting symptoms, and at least two of a variety of other neuropsychiatric symptoms. Detailed clinical presentation of youth with this condition has not yet been provided in the literature. METHODS: We review the clinical charts of five youth meeting criteria for PANS in our PANS Clinic. These five patients were selected for differing underlying causes thought to be driving an inflammatory response that appeared to impact psychiatric symptoms...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25695941/clinical-presentation-of-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections-in-research-and-community-settings
#17
MULTICENTER STUDY
Susan E Swedo, Jakob Seidlitz, Miro Kovacevic, M Elizabeth Latimer, Rebecca Hommer, Lorraine Lougee, Paul Grant
BACKGROUND: The first cases of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) were described >15 years ago. Since that time, the literature has been divided between studies that successfully demonstrate an etiologic relationship between Group A streptococcal (GAS) infections and childhood-onset obsessive-compulsive disorder (OCD), and those that fail to find an association. One possible explanation for the conflicting reports is that the diagnostic criteria proposed for PANDAS are not specific enough to describe a unique and homogeneous cohort of patients...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25695940/special-issue-on-pediatric-acute-onset-neuropsychiatric-syndrome
#18
Kiki Chang, Harold S Koplewicz, Ron Steingard
No abstract text is available yet for this article.
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25344730/cytokine-profiles-by-peripheral-blood-monocytes-are-associated-with-changes-in-behavioral-symptoms-following-immune-insults-in-a-subset-of-asd-subjects-an-inflammatory-subtype
#19
Harumi Jyonouchi, Lee Geng, Amy L Davidow
BACKGROUND: Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (ASD-IS) for this study. We reported a high prevalence of non-IgE mediated food allergy (NFA) in young ASD children before, but not all ASD/NFA children reveal such clinical features of ASD-IS...
2014: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25329522/disordered-eating-and-food-restrictions-in-children-with-pandas-pans
#20
Megan D Toufexis, Rebecca Hommer, Diana M Gerardi, Paul Grant, Leah Rothschild, Precilla D'Souza, Kyle Williams, James Leckman, Susan E Swedo, Tanya K Murphy
OBJECTIVE: Sudden onset clinically significant eating restrictions are a defining feature of the clinical presentation of some of the cases of pediatric acute-onset neuropsychiatric syndrome (PANS). Restrictions in food intake are typically fueled by contamination fears; fears of choking, vomiting, or swallowing; and/or sensory issues, such as texture, taste, or olfactory concerns. However, body image distortions may also be present. We investigate the clinical presentation of PANS disordered eating and compare it with that of other eating disorders...
February 2015: Journal of Child and Adolescent Psychopharmacology
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