keyword
https://read.qxmd.com/read/38513497/-plant-golden-c-sativus-qualitative-and-quantitative-analysis-of-major-components-in-stigmas-and-petals-and-their-biological-activity-in-vitro
#1
JOURNAL ARTICLE
Xue Li, Jiao Song, Jin Tan, Dingkun Zhang, Yongmei Guan, Funeng Geng, Ming Yang, Jin Pei, Hongyan Ma
Crocus sativus L. (C. sativus) has its stigma as the main valuable part used. With extremely low production and high prices, stigma is considered a scarce resource. As a result, its petals, considered as by-products, are often discarded, leading to significant waste. We developed a UPLC-Q-Orbitrap HRMS method for qualitative analysis of stigmas and petals and a UHPLC-QQQ-MS/MS method for simultaneous quantification of 9 characteristic active compounds for the first time, and compared their biological activity in vitro...
March 17, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38500021/functional-analysis-and-comparative-genomics-of-rahnella-perminowiae-s11p1-and-variovorax-sp-s12s4-two-plant-growth-promoting-rhizobacteria-isolated-from-crocus-sativus-l-saffron-rhizosphere
#2
JOURNAL ARTICLE
Rahma Zouagui, Houda Zouagui, Jamal Aurag, Azeddine Ibrahimi, Laila Sbabou
BACKGROUND: Rahnella perminowiae S11P1 and Variovorax sp. S12S4 are two plant growth-promoting rhizobacteria that were previously isolated from the rhizosphere of Crocus sativus L. (saffron), and have demonstrated interesting PGP activities and promising results when used as inoculants in field trials. To further elucidate the molecular mechanisms underlying their beneficial effects on plant growth, comprehensive genome mining of S11P1 and S12S4 and comparative genomic analysis with closely related strains were conducted...
March 18, 2024: BMC Genomics
https://read.qxmd.com/read/38459965/enhancing-the-purification-of-crocin-i-from-saffron-through-the-combination-of-multicolumn-countercurrent-chromatography-and-green-solvents
#3
JOURNAL ARTICLE
Mohammad Hooshyari Ardakani, Chiara Nosengo, Simona Felletti, Martina Catani, Alberto Cavazzini, Chiara De Luca, Hassan Rezadoost
Crocin-I, a valuable natural compound found in saffron (Crocus sativus L.), is the most abundant among the various crocin structures. Developing a cost-effective and scalable purification process to produce high-purity crocin-I is of great interest for future investigations into its biological properties and its potential applications in the treatment of neurological disorders. However purifying crocin-I through single-column preparative chromatography (batch) poses a yield-purity trade-off due to structural similarities among crocins, meaning that the choice of the collection window sacrifices either yield in benefit of higher purity or vice versa...
March 9, 2024: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/38455530/health-risk-assessment-of-heavy-metals-in-saffron-crocus-sativus-l-cultivated-in-domestic-wastewater-and-lake-water-irrigated-soils
#4
JOURNAL ARTICLE
Sami Abou Fayssal, Pankaj Kumar, Simona M Popescu, Mehraj Ud-Din Khanday, Hasan Sardar, Riaz Ahmad, Deep Gupta, Sudhir Kumar Gaur, Hesham F Alharby, Abdullah G Al-Ghamdi
Irrigation of crops with domestic wastewater (DW) is a common practice in developing countries like India. However, domestic wastewater irrigation poses a risk of migration of toxic heavy metals to edible parts of crops, which requires serious measures to prevent their uptake. In this study, the effect of DW irrigation in comparison with Sarbal Lake water (SLW) and borewell water (BW) on soil characteristics and cultivated saffron ( Crocus sativus L.) was investigated. For this purpose, samples of water, soil, and saffron (corm, petal, and stigma) were collected from the suburban area of Pampore, Srinagar district, Jammu and Kashmir, India...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38446350/therapeutic-potential-of-saffron-in-brain-disorders-from-bench-to-bedside
#5
REVIEW
Erjola Bej, Anna Rita Volpe, Patrizia Cesare, Annamaria Cimini, Michele d'Angelo, Vanessa Castelli
Saffron is a spice derived from the flower of Crocus sativus L., which has been used for centuries as a coloring and flavoring agent, as well as a source of medicinal compounds. Saffron contains various bioactive constituents, such as crocin, crocetin, safranal, picrocrocin, and kaempferol, that have shown potential benefits for human health. Among them, crocin is the most abundant and characteristic constituent of saffron, responsible for its bright red color and antioxidant properties. One of the most promising applications of saffron and its constituents is in the prevention and treatment of neurological disorders, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and other brain disorders...
March 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38435850/transcriptome-wide-identification-characterization-and-expression-analysis-of-phd-gene-family-in-crocus-sativus
#6
JOURNAL ARTICLE
Aubid Hussain Malik, Nargis Khurshaid, Najwa Shabir, Nasheeman Ashraf
UNLABELLED: Crocus sativus L., of the Iridaceae family, yields world's most prized spice, saffron. Saffron is well known for its distinctive aroma, odour and colour, which are imputed to the presence of some specific glycosylated apocarotenoids. Even though the main biosynthetic pathway and most of the enzymes leading to apocarotenoid production have been identified, the regulatory mechanisms that govern the developmental stage and tissue specific production of apocarotenoids in Crocus remain comparatively unravelled...
January 2024: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://read.qxmd.com/read/38424688/new-horizons-for-the-study-of-saffron-crocus-sativus-l-and-its-active-ingredients-in-the-management-of-neurological-and-psychiatric-disorders-a-systematic-review-of-clinical-evidence-and-mechanisms
#7
REVIEW
Shufen Han, Yifei Cao, Xingrong Wu, Jiaoyang Xu, Zizheng Nie, Yue Qiu
Saffron (Crocus sativus), as an herbal medicine, has been extensively investigated for treating neurological and psychiatric disorders. This systematic review aimed to assess the overall effects of saffron on cognition, depression, anxiety, sleep disorders, attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD). Relevant randomized controlled trials (RCTs) were identified by searching PubMed/Medline, Web of Science, and Clinical Trials databases up to June 2023 according to search terms and inclusion criteria...
February 29, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38421572/synthesis-of-bimetallic-palladium-zinc-oxide-nanocomposites-using-crocus-sativus-and-its-anticancer-activity-via-the-induction-of-apoptosis-in-cervical-cancer
#8
JOURNAL ARTICLE
Jun Feng, Leilei He, Jin Qing Hui, Krishnamoorthy Kavithaa, Zhengzheng Xu
Palladium (Pd) and zinc oxide (ZnO) (Pd/ZnO NPs) bimettalic nanocomposites still lag much too far behind other nanoparticles investigated for various biological uses in the area of cancer treatments. Chemically created nanoparticles agglomerate under physiological conditions, impeding their use in biomedical applications. In this study, a straightforward and environmentally friendly method for creating bimetallic nanoparticles (NPs) by combining palladium (Pd) and zinc oxide (ZnO) using Crocus sativus extract (CS-Pd/ZnO NCs) was reported; the bio-synthesize bimetallic palladium/zinc oxide nanocomposites and their antioxidant and anti-cancer properties were assessed...
February 29, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38419885/an-overview-of-pharmacological-effects-of-crocus-sativous-and-its-constituents
#9
REVIEW
Saeideh Saadat, Zahra Ghasemi, Arghavan Memarzia, Sepideh Behrouz, Mohammad Reza Aslani, Mohammad Hossein Boskabady
Crocus sativus L. was used for the treatment of a wide range of disorders in traditional medicine. Due to the extensive protective and treatment properties of C. sativus and its constituents in various diseases, the purpose of this review is to collect a summary of its effects, on experimental studies, both in vitro and in vivo . Databases such as PubMed, Science Direct, and Scopus were explored until January 2023 by employing suitable keywords. Several investigations have indicated that the therapeutic properties of C...
2024: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/38385429/randomized-double-blind-placebo-controlled-clinical-trial-of-concurrent-use-of-crocin-during-chemoradiation-for-esophageal-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Nima Ebrahimi, Seyed Alireza Javadinia, Roham Salek, Azar Fanipakdel, Samaneh Sepahi, Mansoureh Dehghani, Niloufar Valizadeh, Seyed Ahmad Mohajeri
Crocin is the major active carotenoid of saffron (Crocus sativus L.). Its pluripotent effects have led to a growing body of literature investigating its antitumor properties as well as its diverse potentials for mood stabilization, normal tissue protection, and inflammation reduction; However, there is a gap in clinical trials testing this substance in cancer patients. In this randomized, double-blind, placebo-controlled clinical trial, patients with newly diagnosed esophageal squamous cell carcinoma were randomly assigned to either 30 mg/day of crocin or placebo, prescribed during the neoadjuvant chemo-radiotherapy...
February 22, 2024: Cancer Investigation
https://read.qxmd.com/read/38370513/mining-of-disease-resistance-genes-in-crocus-sativus-based-on-transcriptome-sequencing
#11
JOURNAL ARTICLE
Dongdong Ye, Siwei Zhang, Xiankui Gao, Xiujuan Li, Xin Jin, Min Shi, Guoyin Kai, Wei Zhou
Introduction: Crocus sativus L. has an important medicinal and economic value in traditional perennial Chinese medicine. However, due to its unique growth characteristics, during cultivation it is highly susceptible to disease. The absence of effective resistance genes restricts us to breed new resistant varieties of C. sativus . Methods: In present study, comprehensive transcriptome sequencing was introduced to explore the disease resistance of the candidate gene in healthy and corm rot-infected C. sativus ...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38370196/valorization-of-saffron-crocus-sativus-l-stigma-as-a-potential-natural-antioxidant-for-soybean-glycine-max-l-oil-stabilization
#12
JOURNAL ARTICLE
Moussa Nid Ahmed, Karima Abourat, Jamila Gagour, El Hassan Sakar, Khalid Majourhat, Jamal Koubachi, Said Gharby
Synthetic antioxidants are known for their efficiency to improve vegetable oil oxidative stability. But owing to their harmful effects on human health, edible oil industry is seeking for safe and healthy natural antioxidants. The present work was setup with the aim of improving soybean oil (SO) oxidative stability by using saffron ( Crocus sativus L.) stigmas collected in Morocco. Saffron stigmas were used as a natural antioxidant at various concentrations (0.2, 0.3, and 0.6%) in soybean oil compared to tocobiol (0...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38367937/l-effet-du-safran-et-de-ses-extraits-sur-le-traitement-du-cancer-du-sein-une-revue-narrative
#13
REVIEW
Roya Mokhtarian, Soodeh Rajabi, Setareh Zahedian, Saeideh Jafarinejad-Farsangi, Morteza Hadizadeh, Masoumeh Sadeghinejad
Breast cancer (BC) is the most prevalent malignancy in women and the second most common disease worldwide, affecting approximately one million individuals annually. Despite the efficacy of conventional chemotherapy, medication resistance and adverse effects limit its effectiveness, leading researchers to explore alternative treatments, including herbal remedies. Saffron, a well-known spice derived from the Crocus sativus L. plant, has shown potential as a BC treatment. The active components of saffron exhibit anti-cancer properties by inducing apoptosis, inhibiting cell division, and modulating signaling pathways implicated in cancer development, such as PI3K/AKT, NF-B, and MAPK...
February 15, 2024: Annales Pharmaceutiques Françaises
https://read.qxmd.com/read/38341114/saffron-crocus-sativus-l-extract-attenuates-chronic-scopolamine-induced-cognitive-impairment-amyloid-beta-and-neurofibrillary-tangles-accumulation-in-rats
#14
JOURNAL ARTICLE
Komal S Patel, Abhay Dharamsi, Madhu Priya, Sanskar Jain, Vishal Mandal, Aboli Girme, Siddharth J Modi, Lal Hingorani
ETHNOPHARMACOLOGICAL RELEVANCE: Crocus sativus L. known as saffron, is a popular food condiment with a high aroma, deep colour, and long and thick threads (stigmas) cultivated in Iran, Morocco, Spain, Italy, China, Japan, France, Turkey, and India. In 'Ayurveda', saffron is acknowledged for its immunostimulant, aphrodisiac, cardiotonic, liver tonic, nervine tonic, carminative, diaphoretic, diuretic, emmenagogue, galactagogue, febrifuge, sedative, relaxant, and anxiolytic activities. The renowned Persian physician and philosopher, Avicenna, delineated saffron as an antidepressant, hypnotic, anti-inflammatory, hepatoprotective, bronchodilator, and aphrodisiac in his book, the Canon of Medicine...
February 8, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38340171/comparative-analysis-of-mirna-expression-profiles-in-flowering-and-non-flowering-tissue-of-crocus-sativus-l
#15
JOURNAL ARTICLE
Archana Bhat, Sonal Mishra, Sanjana Kaul, Manoj Kumar Dhar
Crocus sativus is a valuable plant due to the presence of apocarotenoids in its stigma. Considerable work has been done in the past to understand the apocarotenoid biosynthetic pathway in saffron. However, the reports on understanding the regulation of flowering at the post-transcriptional level are meagre. The study aimed to discover the candidate miRNAs, target genes, transcription factors (TFs), and apocarotenoid biosynthetic pathway genes associated with the regulation and transition of flowering in C. sativus...
February 10, 2024: Protoplasma
https://read.qxmd.com/read/38334707/a-rapid-and-sensitive-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-method-for-determination-of-phytohormones-in-the-medicinal-plant-saffron
#16
JOURNAL ARTICLE
Jing Chen, Yuanyuan Tao, Shuhui Yang, Fengqin Jiang, Guifen Zhou, Xiaodong Qian, Yuehong Zhu, Liqin Li
Saffron ( Crocus sativus L.) is a valuable Chinese herb with high medicinal value. Saffron pistils are used as medicine, so increasing the number of flowers can increase the yield. Plant hormones have essential roles in the growth and development of saffron, as well as the response to biotic and abiotic stresses (especially in floral initiation), which may directly affect the number of flowers. Quantitative analysis of plant hormones provides a basis for more efficient research on their synthesis, transportation, metabolism, and action...
February 9, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38318672/crocus-sativus-tepals-extract-suppresses-subcutaneous-adipose-tissue-hypertrophy-and-improves-systemic-insulin-sensitivity-in-mice-on-high-fat-diet
#17
JOURNAL ARTICLE
Biljana Bursać, Luisa Bellachioma, Ljupka Gligorovska, Mirna Jovanović, Ana Teofilović, Miloš Vratarić, Danijela Vojnović Milutinović, Alfonso Albacete, Purificación A Martínez-Melgarejo, Camilla Morresi, Elisabetta Damiani, Tiziana Bacchetti, Ana Djordjevic
Obesity is a pressing problem worldwide for which standard therapeutic strategies have limited effectiveness. The use of natural products seems to be a promising approach to alleviate obesity and its associated complications. The tepals of Crocus sativus (Cr) plant, usually wasted in saffron production, are an unexplored source of bioactive compounds. Our aim was to elucidate the mechanisms of Cr tepals extract in obesity by investigating its effects on adipocyte differentiation, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) hypertrophy, and lipid metabolism in an animal model of diet-induced obesity...
February 6, 2024: BioFactors
https://read.qxmd.com/read/38292670/biochar-based-organic-fertilizers-influence-on-yield-and-concentration-of-antioxidants-in-the-stigma-of-saffron-and-rhizosphere-bacterial-diversity-of-slightly-saline-and-non-saline-soils
#18
JOURNAL ARTICLE
Shagufta Qasim, Shamim Gul, Abdul Hanan Buriro, Fahad Shafiq, Tariq Ismail
Being the most expensive spice, saffron has great economic importance. This crop grows well in cold arid deserts. Salinity is one of the important limiting factors for the cultivation of this crop. However, the use of composted manured and co-composted biochar and fertilizers can play a role in attenuating the salinity stress on this crop. In this two-year field study, manures from three sources: sheep and goat ( SG ), cow and buffalo ( FYM ), and poultry ( PM ) farms, and their co-compost with slow-pyrolyzed wood-derived biochar (B) were used for saffron cultivation in slightly saline (electrical conductivity 1...
March 2024: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/38286072/crocetin-inhibits-mast-cell-dependent-immediate-type-allergic-reactions-through-ca-2-plc-ip3-and-tnf-pathway
#19
JOURNAL ARTICLE
Ting Fan, Kai Jiang, Zixiao Wang, Yu Chang, Hua Tian, Jing Huang
Crocetin is a kind of glycocone naturally occurring in Crocus sativus L.. It is an active metabolite produced by biohydrolysis of Crocus sativus L.. Crocetin has anti-cardiovascular diseases and antioxidant effects, but its anti-allergic effect has not been reported. In this study, the inhibitory effect of crocetin on immunoglobulin E (IgE) - mediated allergic reaction and the mechanism of action were investigated. The passive cutaneous anaphylaxis (PCA) was used to elucidate the anti-allergic effects of crocetin in vivo...
January 27, 2024: International Immunopharmacology
https://read.qxmd.com/read/38250179/effects-of-biocontrol-bacillus-sp-strain-d5-on-the-pathogenic-fusarium-oxysporum-r1-at-the-microscopic-and-molecular-level-in-crocus-sativus-l-saffron-corm
#20
JOURNAL ARTICLE
Nancy Bhagat, Jyoti Vakhlu
Corm rot of saffron caused by Fusarium oxysporum is a major threat to saffron cultivation the world over. To minimize the ill effects of chemical fungicides, attention has been shifted to the use of biocontrol agents for disease management in a sustainable way. In saffron, various biocontrol agents against corm rot disease have been reported and characterized but no study has been done so far to understand their interaction at the molecular level. The present study was conducted to unravel the mechanism of action of an already characterized native biocontrol agent i...
2024: FEMS Microbes
keyword
keyword
56934
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.