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Crocus sativus

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https://www.readbyqxmd.com/read/28298158/intake-of-saffron-reduces-%C3%AE-radiation-induced-genotoxicity-and-oxidative-stress-in-mice
#1
Apurva Koul, Suresh K Abraham
Saffron (SAF), the dried stigmas of Crocus sativus is commonly used for flavouring and coloring food. Studies on bioactivity of SAF have demonstrated its in vivo antioxidant activity. The aim of our study was to assess the impact of SAF intake on γ-radiation (RAD) induced: (a) chromosomal damage, (b) oxidative stress in liver and brain and (c) histopathological effects in the intestinal cells and male germ cells in mice. Freeze-dried aqueous extract of SAF was used for the experiments. Our preliminary cell-free DNA nicking assay using pBR322 DNA revealed protective effects of freeze-dried SAF extract against hydroxyl radical induced DNA damage...
March 15, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28293386/toxicology-effects-of-saffron-and-its-constituents-a-review
#2
REVIEW
Hasan Badie Bostan, Soghra Mehri, Hossein Hosseinzadeh
Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron. However, a comprehensive review that covers all aspects of its toxicity has not been published yet. The current study provides classified information about the toxic effects of saffron and its constituents in various exposure conditions including acute, sub-acute, sub-chronic and chronic studies...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28278645/short-communication-investigating-the-effect-of-saffron-crocus-sativus-l-nano-sizing-on-its-colour-extraction-efficiency-a-preliminary-study
#3
Mehrdad Abootalebian, Maryam Karbasi, Maliheh Sadeghi, Mahnaz Abdinian, Igor Polikarpov
This study investigated the effect of saffron nano-sizing on its the colour extraction yield. The whole stigma was ball-milled at three different times (10, 20 and 100 h), immediately or with a 24 h delay was submitted to absorption test, and then the colour extraction efficiency was determined. When stigma was milled for 100 h, its particle size was reduced to less than 20 nm, as shown by SEM and TEM images, and its extraction efficiency was considerably increased by 19.8% as compared with the stigma blended for 10 min...
February 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28261627/in-silico-identification-of-mirnas-and-their-target-genes-and-analysis-of-gene-co-expression-network-in-saffron-crocus-sativus-l-stigma
#4
Zahra Zinati, Roohollah Shamloo-Dashtpagerdi, Ali Behpouri
As an aromatic and colorful plant of substantive taste, saffron (Crocus sativus L.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. Regarding the critical role of microRNAs in secondary metabolic synthesis and the limited number of identified miRNAs in C. sativus, on the other hand, one may see the point how the characterization of miRNAs along with the corresponding target genes in C. sativus might expand our perspectives on the roles of miRNAs in carotenoid/apocarotenoid biosynthetic pathway...
December 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28247040/transcriptome-wide-identification-phylogenetic-analysis-and-expression-profiling-of-zinc-finger-transcription-factors-from-crocus-sativus-l
#5
Aubid Hussain Malik, Nasheeman Ashraf
Crocus sativus belongs to Iridaceae family and is the only plant species which produces apocarotenoids like crocin, picrocrocin, and safranal in significant quantities. Besides their organoleptic properties, Crocus apocarotenoids have been found to possess remarkable pharmacological potential. Although apocarotenoid biosynthetic pathway has been worked out to a great degree, but the mechanism that regulates the tissue and developmental stage-specific production of Crocus apocarotenoids is not known. To identify the genes regulating apocarotenoid biosynthesis in Crocus, transcriptome wide identification of zinc-finger transcription factors was undertaken...
February 28, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28216334/crocins-the-active-constituents-of-crocus-sativus-l-counteracted-apomorphine-induced-performance-deficits-in-the-novel-object-recognition-task-but-not-novel-object-location-task-in-rats
#6
Nikolaos Pitsikas, Petros A Tarantilis
Schizophrenia is a chronic mental disease that affects nearly 1% of the population worldwide. Several lines of evidence suggest that the dopaminergic (DAergic) system might be compromised in schizophrenia. Specifically, the mixed dopamine (DA) D1/D2 receptor agonist apomorphine induces schizophrenia-like symptoms in rodents, including disruption of memory abilities. Crocins are among the active components of saffron (dried stigmas of Crocus sativus L. plant) and their implication in cognition is well documented...
February 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28215156/medicinal-plants-targeting-cardiovascular-diseases-in-view-of-avicenna
#7
Zahra Sobhani, Saeed Reza Nami, Seyed Ahmad Emami, Amirhossein Sahebkar, Behjat Javadi
BACKGROUND: Cardiovascular disease (CVD) is a spectrum of diseases involving the heart and blood vessels, and the first cause of mortality worldwide. Medicinal plants have been used for thousands of years to treat CVD. In Traditional Persian Medicine (TPM), there is a special focus on heart diseases. Avicenna, a Persian physician of the eleventh century compiled a book devoted to this field named "The treatise on cardiac drugs" which is a compendium of TPM knowledge on CVD. Avicenna mentioned 50 cardiovascular active plants and described their therapeutic effects in the treatment of CVDs...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28154174/functional-characterization-of-csbglu12-a-%C3%AE-glucosidase-from-crocus-sativus-provides-insights-into-its-role-in-abiotic-stress-through-accumulation-of-antioxidant-flavonols
#8
Shoib Ahmad Baba, Ram A Vishwakarma, Nasheeman Ashraf
Glycosylation and deglycosylation is an impressive mechanism that allows plants to regulate biological activity of an array of secondary metabolites. While glycosylation improves solubility and renders the metabolites suitable for transport and sequestration, deglycosylation activates them to carry out biological functions. Herein, we report functional characterization of CsBGlu12, a β-glucosidase from Crocus sativus. CsBGlu12 has a characteristic glucoside hydrolase 1 family (α/β)8 TIM barrel structure with highly conserved active site...
January 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28145590/molecular-modeling-and-dynamic-simulation-of-arabidopsis-thaliana-carotenoid-cleavage-dioxygenase-gene-a-comparison-with-bixa-orellana-and-crocus-sativus
#9
Priya R, Sneha P, Renata Rivera Madrid, George Priya Doss C, Pooja Singh, Siva Ramamoorthy
Carotenoid cleavage dioxygenase (CCD) gene, ubiquitously found in numerous types of plants, are eminent in synthesizing the various volatile compounds (β-ionone, C13 -norisoprenoid, geranylacetone) known as apocarotenoids. These apocarotenoids have various biological functions such as volatile signals, allelopathic interaction and plant defense. In Arabidopsis genome sequence, four potential CCD genes have been identified namely CCD1, CCD4, CCD7, and CCD8. These four genes give rise to diverse biological functions with almost similar sequence identity...
February 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28111973/efficacy-of-crocin-and-safranal-as-protective-agents-against-genotoxic-stress-induced-by-gamma-radiation-urethane-and-procarbazine-in-mice
#10
A Koul, S K Abraham
Crocin (CRO) and safranal (SAF) are bioactive constituents of saffron (dried stigma of Crocus sativus flower), an expensive spice with medicinal properties. Aqueous extract of saffron is known for its antigenotoxic effect against environmental genotoxins/carcinogens. However, there is need to identify saffron constituents responsible for this antigenotoxic effect. The aim of our investigation was to ascertain the role of CRO and SAF as inhibitors of in vivo genotoxic stress. For this purpose, Swiss albino mice were pretreated with CRO (50-mg/kg body weight (bw))/SAF (0...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28098452/a-perspective-on-crocus-sativus-l-saffron-constituent-crocin-a-potent-water-soluble-antioxidant-and-potential-therapy-for-alzheimer-s-disease
#11
John W Finley, Song Gao
Alzheimer's disease (AD) is the most common form of dementia, in which the death of brain cells causes memory loss and cognitive decline. Several factors are thought to play roles in the development and course of AD. Existing medical therapies only modestly alleviate and delay cognitive symptoms. Current research has been focused on developing antibodies to remove the aggregates of amyloid-β (Aβ) and tau protein. This approach has achieved removal of Aβ; however, no cognitive improvement in AD patients has been reported...
February 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28067784/sailuotong-prevents-hydrogen-peroxide-h%C3%A2-o%C3%A2-induced-injury-in-ea-hy926-cells
#12
Sai Wang Seto, Dennis Chang, Wai Man Ko, Xian Zhou, Hosen Kiat, Alan Bensoussan, Simon M Y Lee, Maggie P M Hoi, Genevieve Z Steiner, Jianxun Liu
Sailuotong (SLT) is a standardised three-herb formulation consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus designed for the management of vascular dementia. While the latest clinical trials have demonstrated beneficial effects of SLT in vascular dementia, the underlying cellular mechanisms have not been fully explored. The aim of this study was to assess the ability and mechanisms of SLT to act against hydrogen peroxide (H₂O₂)-induced oxidative damage in cultured human vascular endothelial cells (EAhy926)...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28025553/special-issue-saffron-crocus-sativus-l-omics-and-other-techniques-in-authenticity-quality-and-bioactivity-studies
#13
EDITORIAL
Maria Tsimidou, Petros A Tarantilis
n/a.
December 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27999238/the-effect-of-safranal-on-th1-th2-cytokine-balance
#14
Reza Feyzi, Mohammad Hossein Boskabady, Seyedeh Masoumeh Seyedhosseini Tamijani, Houshang Rafatpanah, Seyed Abdolrahim Rezaei
BACKGROUND: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. OBJECTIVE: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. METHODS: Effects of Safranal at 0.1, 0.5 and 1 mM concentrations were evaluated on cell viability and production of interleukin 4 (IL-4), IL-10 and interferon-γ (IFN-γ) from non-stimulated and phytohemagglutinin (PHA) stimulated PBMCs, compared to 0...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27987758/nanostructured-lipid-dispersions-for-topical-administration-of-crocin-a-potent-antioxidant-from-saffron-crocus-sativus-l
#15
Elisabetta Esposito, Markus Drechsler, Paolo Mariani, Anna Maria Panico, Venera Cardile, Lucia Crascì, Federica Carducci, Adriana Carol Eleonora Graziano, Rita Cortesi, Carmelo Puglia
Crocin, a potent antioxidant obtained from saffron, shows anticancer activity in in vivo models. Unfortunately unfavorable physicochemical features compromise its use in topical therapy. The present study describes the preparation and characterization of nanostructured lipid dispersions as drug delivery systems for topical administration of crocin and the evaluation of antioxidant and antiproliferative effects of crocin once encapsulated into nanostructured lipid dispersions. Nanostructured lipid dispersions based on monoolein in mixture with sodium cholate and sodium caseinate have been characterized by cryo-TEM and PCS...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27979284/geographical-characterization-by-mae-hplc-and-nir-methodologies-and-carbonic-anhydrase-inhibition-of-saffron-components
#16
Riccardo Nescatelli, Simone Carradori, Federico Marini, Vicky Caponigro, Remo Bucci, Celeste De Monte, Adriano Mollica, Luisa Mannina, Mariangela Ceruso, Claudiu T Supuran, Daniela Secci
A microwave-assisted extraction method was optimised for the recovery of bioactive compounds from Crocus sativus L. stigmas with the use of water/ethanol mixture. HPLC-DAD was employed to evaluate the extraction parameters, in particular, solvent type and volume, and the duration of the procedure. Microwave-assisted extraction enhanced the recovery of the active principles, limiting extraction time and solvent waste. Moreover, NIR experiments were performed in order to compare spectra in pseudo-absorbance of Saffron samples with different geographical origins through the application of the chemometric techniques...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27976237/quality-control-of-saffron-crocus-sativus-l-via-a-novel-hplc-method
#17
K Kuchta, H H Jin, R W Wang, H H He, L Fang, J B Yao
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27894973/is-there-nothing-new-under-the-sun-the-influence-of-herbals-and-pharmacopoeias-on-ethnobotanical-traditions-in-albacete-spain
#18
Diego Rivera, Alonso Verde, Concepción Obón, Francisco Alcaraz, Candelaria Moreno, Teresa Egea, José Fajardo, José Antonio Palazón, Arturo Valdés, Maria Adele Signorini, Piero Bruschi
ETHNOPHARMACOLOGICAL RELEVANCE: This paper has two overarching aims: (1) presenting the results of studying the Albacete tariff of medicines of 1526 and (2) broadly analyzing the origin and influences of medicinal traditional knowledge in the region of Albacete, Spain. We use historical and modern literature that may have influenced this knowledge. Our primary goal was to determine the ingredients used in the pharmacy in the 16th century CE in Albacete through the analysis of the tariff, and our secondary goal was to investigate until when ingredients and uses present in pharmacy and herbals persisted in later periods...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27890087/molecular-phylogeny-diversity-community-structure-and-plant-growth-promoting-properties-of-fungal-endophytes-associated-with-the-corms-of-saffron-plant-an-insight-into-the-microbiome-of-crocus-sativus-linn
#19
Zahoor Ahmed Wani, Dania Nazir Mirza, Palak Arora, Syed Riyaz-Ul-Hassan
A total of 294 fungal endophytes were isolated from the corms of Crocus sativus at two stages of crocus life cycle collected from 14 different saffron growing sites in Jammu and Kashmir (J & K) State, India. Molecular phylogeny assigned them into 36 distinct internal transcribed spacer (ITS) genotypes which spread over 19 genera. The diversity of endophytes was higher at the dormant than at the vegetative stage. The Saffron microbiome was dominated by Phialophora mustea and Cadophora malorum, both are dark septate endophytes (DSEs)...
December 2016: Fungal Biology
https://www.readbyqxmd.com/read/27878268/crocus-sativus-l-protects-against-sds%C3%A2-induced-intestinal-damage-and-extends-lifespan-in-drosophila-melanogaster
#20
Zonglin Liu, Yuchen Chen, Hong Zhang, Li Hua Jin
Medicinal plants are important sources of potentially therapeutic biochemical drugs. Crocus sativus L. has been used to treat various diseases in China, the Republic of Korea and Japan. The present study investigated the protective effect of C. sativus L. extract in Drosophila melanogaster intestinal immunity. Wild‑type flies were fed standard cornmeal‑yeast medium and used as controls, and flies supplemented with 1% C. sativus L. aqueous extract in standard medium were used as the experimental group...
December 2016: Molecular Medicine Reports
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