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Copd challenge model

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https://www.readbyqxmd.com/read/28980785/-doctor-i-m-afraid-of-suffocating-copd-and-psychiatric-manifestations
#1
Stéphane Henninger, Doris Calamand, Olivier Pasche, Giorgio E Maccaferri
The chronic obstructive pulmonary disease is a frequent and increasing disease in Western countries. Psychiatric comorbidities, such as depression or anxiety, are often observed and have a major impact on the quality of life and on the prognosis of the patients. Several models based on physiopathological and behavioral psychotherapy researches help us to understand this association between somatic and psychiatric disease. The detection and the treatment of these comorbidities are challenges for the practitioner and make a multidisciplinary approach recommended...
October 4, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28976240/hsp60-activity-on-human-bronchial-epithelial-cells
#2
Claudia Sangiorgi, Davide Vallese, Isabella Gnemmi, Fabio Bucchieri, Bruno Balbi, Paola Brun, Angelo Leone, Andrea Giordano, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello, Antonino Di Stefano
HSP60 has been implicated in chronic inflammatory disease pathogenesis, including chronic obstructive pulmonary disease (COPD), but the mechanisms by which this chaperonin would act are poorly understood. A number of studies suggest a role for extracellular HSP60, since it can be secreted from cells and bind Toll-like receptors; however, the effects of this stimulation have never been extensively studied. We investigated the effects (pro- or anti-inflammatory) of HSP60 in human bronchial epithelial cells (16-HBE) alone and in comparison with oxidative, inflammatory, or bacterial challenges...
October 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28960804/angiotensin-1-7-mediated-mas1-receptor-nf-%C3%AE%C2%BAb-p65-signaling-is-involved-in-a-cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-mouse-model
#3
Yong Zhang, Yang Li, Ce Shi, Xiaomin Fu, Lingdi Zhao, Yongping Song
Angiotensin-(1-7) [Ang-(1-7)] has been shown to play a significant role in the pathogenesis of lung inflammation via Mas receptor; however, its effect in chronic obstructive pulmonary disease (COPD) remains unknown. To explore the effect of Ang-(1-7) on a cigarette smoke (CS) exposure-induced COPD model, 40 C57BL/6J mice were divided into four groups (n = 10) and exposed to air or CS for 8 weeks. After that, they were treated with saline or Ang-(1-7) at 0.3 mg/kg for 2 weeks by subcutaneous infusion using osmotic pump...
September 28, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28895883/the-effects-of-resveratrol-on-inflammation-and-oxidative-stress-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#4
Xiao-Li Wang, Ting Li, Ji-Hong Li, Shu-Ying Miao, Xian-Zhong Xiao
Oxidative stress and inflammation are hypothesized to contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Resveratrol (trans-3,5,4'-trihydroxystilbene) is known for its antioxidant and anti-inflammatory properties. The study aimed to investigate the effects of resveratrol in a rat model with COPD on the regulation of oxidative stress and inflammation via the activation of Sirtuin1 (SIRTl) and proliferator-activated receptor-γ coactivator-1α (PGC-1α). Thirty Wistar rats were randomly divided into three groups: control group, COPD group and resveratrol intervention group...
September 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28868892/home-based-pulmonary-rehabilitation-for-people-with-copd-a-qualitative-study-reporting-the-patient-perspective
#5
Aroub Lahham, Christine F McDonald, Ajay Mahal, Annemarie L Lee, Catherine J Hill, Angela T Burge, Narelle S Cox, Rosemary Moore, Caroline Nicolson, Paul O'Halloran, Rebecca Gillies, Anne E Holland
This study aimed to document the perspective of patients with chronic obstructive pulmonary disease (COPD) who underwent home-based pulmonary rehabilitation (HBPR) in a clinical trial. In this qualitative study, open-ended questions explored participants' views regarding HBPR. Thirteen semi-structured interviews were analysed using a thematic analysis approach. Major themes from interviews included the positive impact of HBPR on physical fitness, breathing and mood. Participants valued the flexibility and convenience of the programme...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28853985/a-moraxella-catarrhalis-vaccine-to-protect-against-otitis-media-and-exacerbations-of-copd-an-update-on-current-progress-and-challenges
#6
Antonia C Perez, Timothy F Murphy
Moraxella catarrhalis is a major cause of morbidity and mortality worldwide, especially causing otitis media in young children and exacerbations of chronic obstructive pulmonary disease in adults. This pathogen employs several virulence mechanisms to colonize and survive in its host, including adherence and invasion of host cells, formation of polymicrobial biofilms with other bacterial pathogens and production of beta-lactamase. Given the global impact of otitis media and COPD, an effective vaccine to prevent M...
August 30, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28814852/prognostic-variables-and-scores-identifying-the-end-of-life-in-copd-a-systematic-review
#7
REVIEW
Laura-Jane E Smith, Elizabeth Moore, Ifrah Ali, Liam Smeeth, Patrick Stone, Jennifer K Quint
INTRODUCTION: COPD is a major cause of mortality, and the unpredictable trajectory of the disease can bring challenges to end-of-life care. We aimed to investigate known prognostic variables and scores that predict prognosis in COPD in a systematic literature review, specifically including variables that contribute to risk assessment of patients for death within 12 months. METHODS: We conducted a systematic review on prognostic variables, multivariate score or models for COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28798199/human-cerebral-blood-flow-control-during-hypoxia-focus-on-chronic-pulmonary-obstructive-disease-copd-and-obstructive-sleep-apnea-osa
#8
Andrew E Beaudin, Sara E Hartmann, Matiram Pun, Marc J Poulin
The brain is a vital organ that relies on a constant and adequate blood flow to match oxygen and glucose delivery with the local metabolic demands of active neurons. Thus, exquisite regulation of cerebral blood flow (CBF) is particularly important under hypoxic conditions to prevent a detrimental decrease in the partial pressure of oxygen within the brain tissues. Cerebrovascular sensitivity to hypoxia, assessed as the change in CBF during a hypoxic challenge, represents the capacity of cerebral vessels to respond to, and compensate for, a reduced oxygen supply, and has been shown to be impaired or blunted in a number of conditions...
August 10, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28676846/inactivation-of-the-thymidylate-synthase-thya-in-non-typeable-haemophilus-influenzae-modulates-antibiotic-resistance-and-has-a-strong-impact-on-its-interplay-with-the-host-airways
#9
Irene Rodríguez-Arce, Sara Martí, Begoña Euba, Ariadna Fernández-Calvet, Javier Moleres, Nahikari López-López, Montserrat Barberán, José Ramos-Vivas, Fe Tubau, Carmen Losa, Carmen Ardanuy, José Leiva, José E Yuste, Junkal Garmendia
Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can modify the biology of infection. The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) is frequently encountered in the lower airways of chronic obstructive pulmonary disease (COPD) patients, and associated with acute exacerbation of COPD symptoms...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28659326/a-cation-binding-surface-protein-as-a-vaccine-antigen-to-prevent-moraxella-catarrhalis-otitis-media-and-infections-in-chronic-obstructive-pulmonary-disease
#10
Timothy F Murphy, Aimee L Brauer, Antoinette Johnson, Gregory E Wilding, Mary Koszelak-Rosenblum, Michael G Malkowski
Moraxella catarrhalis is an exclusively human respiratory tract pathogen that is a common cause of otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. A vaccine to prevent these infections would have a major impact in reducing the substantial global morbidity and mortality in these populations. Through a genome mining approach, we identified AfeA, an ∼32 kDa substrate binding protein of an ABC transport system as an excellent candidate vaccine antigen...
June 28, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28657170/the-past-decade-in-bench-research-into-pulmonary-infectious-diseases-what-do-clinicians-need-to-know
#11
REVIEW
Simon Finch, Holly R Keir, Alison J Dicker, James D Chalmers
Respiratory infections are primarily treated with antibiotics, drugs that are mostly inexpensive and have been widely available since the 1940s and 1950s. Nevertheless, despite antibiotics, the burden of disease in pneumonia, bronchiectasis, cystic fibrosis, COPD and rare respiratory infections remains exceptionally high. There is an urgent need for translational studies to develop new treatments or new biomarkers to improve outcomes in these conditions. The 'translational gaps' between bench science and clinical practice are particularly challenging in respiratory infections...
June 28, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28644419/context-relevant-prediction-model-for-copd-domain-using-bayesian-belief-network
#12
Hamid Mcheick, Lokman Saleh, Hicham Ajami, Hafedh Mili
In the last three decades, researchers have examined extensively how context-aware systems can assist people, specifically those suffering from incurable diseases, to help them cope with their medical illness. Over the years, a huge number of studies on Chronic Obstructive Pulmonary Disease (COPD) have been published. However, how to derive relevant attributes and early detection of COPD exacerbations remains a challenge. In this research work, we will use an efficient algorithm to select relevant attributes where there is no proper approach in this domain...
June 23, 2017: Sensors
https://www.readbyqxmd.com/read/28557543/impaired-mitochondrial-microbicidal-responses-in-chronic-obstructive-pulmonary-disease-macrophages
#13
Martin A Bewley, Julie A Preston, Mohammed Mohasin, Helen M Marriott, Richard C Budd, Julie Swales, Paul Collini, David R Greaves, Ruth W Craig, Christopher E Brightling, Louise E Donnelly, Peter J Barnes, Dave Singh, Steven D Shapiro, Moira K B Whyte, David H Dockrell
RATIONALE: Chronic obstructive pulmonary disease (COPD) is characterized by impaired clearance of pulmonary bacteria. OBJECTIVES: The effect of COPD on alveolar macrophage (AM) microbicidal responses was investigated. METHODS: AMs were obtained from bronchoalveolar lavage from healthy donors or patients with COPD and challenged with opsonized serotype 14 Streptococcus pneumoniae. Cells were assessed for apoptosis, bactericidal activity, and mitochondrial reactive oxygen species (mROS) production...
October 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28511344/anti-inflammatory-effects-of-trans-anethole-in-a-mouse-model-of-chronic-obstructive-pulmonary-disease
#14
Ka Young Kim, Hui Su Lee, Geun Hee Seol
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that is generally characterized by progressive and irreversible airflow obstruction and alveolar destruction. Long-term treatment with current medications has been associated with various adverse effects, indicating a need for alternative approaches for the prevention and treatment of COPD. This study investigated the mechanism underlying the effects of trans-anethole in a mouse model of COPD induced by porcine pancreatic elastase (PPE) and lipopolysaccharide (LPS)...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28477328/can-chronic-disease-be-managed-through-integrated-care-cost-effectively-evidence-from-a-systematic-review
#15
J Cronin, A Murphy, E Savage
BACKGROUND: The increase in demand for integrated care models to manage chronic disease is a challenge for the Irish health system, which is traditionally organised around the acute hospital services. Implementing integrated care programmes requires significant investment, and thus, their economic impact requires consideration. AIMS: This paper updates the previous evidence on the cost-effectiveness of integrated care programmes to support the development of a cost-effective integrated care programme for chronic disease management...
May 5, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28475040/model-based-estimation-of-respiratory-parameters-from-capnography-with-application-to-diagnosing-obstructive-lung-disease
#16
Abubakar Abid, Rebecca J Mieloszyk, George C Verghese, Baruch S Krauss, Thomas Heldt
OBJECTIVE: We use a single-alveolar-compartment model to describe the partial pressure of carbon dioxide in exhaled breath, as recorded in time-based capnography. Respiratory parameters are estimated using this model and then related to the clinical status of patients with obstructive lung disease. METHODS: Given appropriate assumptions, we derive an analytical solution of the model, describing the exhalation segment of the capnogram. This solution is parametrized by alveolar CO2 concentration, dead-space fraction, and the time constant associated with exhalation...
May 2, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28448535/alpha-1-antitrypsin-supplementation-improves-alveolar-macrophages-efferocytosis-and-phagocytosis-following-cigarette-smoke-exposure
#17
Karina A Serban, Daniela N Petrusca, Andrew Mikosz, Christophe Poirier, Angelia D Lockett, Lauren Saint, Matthew J Justice, Homer L Twigg, Michael A Campos, Irina Petrache
Cigarette smoking (CS), the main risk factor for COPD (chronic obstructive pulmonary disease) in developed countries, decreases alveolar macrophages (AM) clearance of both apoptotic cells and bacterial pathogens. This global deficit of AM engulfment may explain why active smokers have worse outcomes of COPD exacerbations, episodes characterized by airway infection and inflammation that carry high morbidity and healthcare cost. When administered as intravenous supplementation, the acute phase-reactant alpha-1 antitrypsin (A1AT) reduces the severity of COPD exacerbations in A1AT deficient (AATD) individuals and of bacterial pneumonia in murine models, but the effect of A1AT on AM scavenging functions has not been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28368678/functional-characterization-of-a-novel-3d-model-of-the-epithelial-mesenchymal-trophic-unit
#18
Fabio Bucchieri, Alessandro Pitruzzella, Alberto Fucarino, Antonella Marino Gammazza, Celeste Caruso Bavisotto, Vito Marcianò, Massimo Cajozzo, Giorgio Lo Iacono, Roberto Marchese, Giovanni Zummo, Stephen T Holgate, Donna E Davies
BACKGROUND/AIM: Epithelial-mesenchymal communication plays a key role in tissue homeostasis and abnormal signaling contributes to chronic airways disease such as COPD. Most in vitro models are limited in complexity and poorly represent this epithelial-mesenchymal trophic unit. We postulated that cellular outgrowth from bronchial tissue would enable development of a mucosal structure that recapitulates better in vivo tissue architecture. MATERIALS AND METHODS: Bronchial tissue was embedded in Matrigel and outgrowth cultures monitored using time-lapse microscopy, electrical resistance, light and electron microscopy...
March 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28340574/myocyte-enhancer-factor-2d-provides-a-cross-talk-between-chronic-inflammation-and-lung-cancer
#19
Hai-Xing Zhu, Lin Shi, Yong Zhang, Yi-Chun Zhu, Chun-Xue Bai, Xiang-Dong Wang, Jie-Bai Zhou
BACKGROUND: Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. Patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), are exposed to a higher risk of developing lung cancer. Chronic inflammation may play an important role in the lung carcinogenesis among those patients. The present study aimed at identifying candidate biomarker predicting lung cancer risk among patients with chronic respiratory diseases. METHODS: We applied clinical bioinformatics tools to analyze different gene profile datasets with a special focus on screening the potential biomarker during chronic inflammation-lung cancer transition...
March 24, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28212463/efficacy-and-tolerability-of-an-inhaled-selective-glucocorticoid-receptor-modulator-azd5423-in-chronic-obstructive-pulmonary-disease-patients-phase-ii-study-results
#20
Piotr Kuna, Magnus Aurivillius, Carin Jorup, Susanne Prothon, Ziad Taib, Staffan Edsbäcker
AZD5423 is a novel, inhaled, selective glucocorticoid receptor modulator (SGRM), which in an allergen challenge model in asthma patients improved lung function and airway hyper-reactivity. In the current trial, AZD5423 was for the first time tested in patients with chronic obstructive pulmonary disease (COPD). In this double-blind, randomized and parallel group study, we examined airway and systemic effects of two doses of AZD5423, inhaled via Turbuhaler for 12 weeks, in 353 symptomatic patients with COPD (average pre-bronchodilator forced expiratory volume in one-second (FEV1) at screening was 50-52% of predicted normal)...
February 17, 2017: Basic & Clinical Pharmacology & Toxicology
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