Slim Fourati, Aarthi Talla, Mehrad Mahmoudian, Joshua G Burkhart, Riku Klén, Ricardo Henao, Thomas Yu, Zafer Aydın, Ka Yee Yeung, Mehmet Eren Ahsen, Reem Almugbel, Samad Jahandideh, Xiao Liang, Torbjörn E M Nordling, Motoki Shiga, Ana Stanescu, Robert Vogel, Gaurav Pandey, Christopher Chiu, Micah T McClain, Christopher W Woods, Geoffrey S Ginsburg, Laura L Elo, Ephraim L Tsalik, Lara M Mangravite, Solveig K Sieberts
The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine whether pre- or early post-exposure molecular factors could predict physiologic responses to viral exposure. Using peripheral blood gene expression profiles collected from healthy subjects prior to exposure to one of four respiratory viruses (H1N1, H3N2, Rhinovirus, and RSV), as well as up to 24 h following exposure, we find that it is possible to construct models predictive of symptomatic response using profiles even prior to viral exposure...
October 24, 2018: Nature Communications