Marcela T Taruselli, Amina Abdul Qayum, Daniel Abebayehu, Heather L Caslin, Jordan M Dailey, Aditya Kotha, Jason R Burchett, Sydney A Kee, Tania D Maldonado, Boyang Ren, Wei Chao, Lin Zou, Tamara T Haque, David Straus, John J Ryan
IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade suppresses asthma-like inflammation in mouse models. Homeostatic control of IL-33 signaling is poorly understood. Because the IL-33 receptor, ST2, acts via cascades used by the TLR family, similar feedback mechanisms may exist. MicroRNA (miR)-146a is induced by LPS-mediated TLR4 signaling and serves as a feedback inhibitor...
February 21, 2024: Journal of Immunology