keyword
https://read.qxmd.com/read/38410598/serum-proteomics-identifies-novel-diagnostic-biomarkers-for-asthma-in-preschool-children
#21
JOURNAL ARTICLE
Hui Ding, Zhaoling Shi, Haibo Lin, Yuan Sun, Lu Zhang, Feiyan Liu, Xuelin Wang, Zhihong Zhang, Guocheng Zhang
BACKGROUND: Asthma is characterized by airway hyperresponsiveness, reversible airway obstruction, and chronic airway inflammation. It is the most common chronic disease in childhood. However, the diagnosis of childhood asthma remains challenging, and there is an urgent need to develop new diagnostic methods. METHODS: To identify biomarkers of asthma in children, we adopted the Orbitrap-based data-independent acquisition (DIA) mass spectrometry proteomics method to analyze the serum proteomic signatures of children with acute asthma and convalescent children...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38401465/morita-baylis-hillman-adduct-2-3-hydroxy-1-methyl-2-oxoindolin-3-il-acrylonitrile-cisacn-ameliorates-the-pulmonary-allergic-inflammation-in-caras-model-by-increasing-ifn-%C3%AE-il-4-ratio-towards-the-th1-immune-response
#22
JOURNAL ARTICLE
Larissa Adilis Maria Paiva Ferreira, Laércia Karla Diega Paiva Ferreira, Raquel Fragoso Pereira Cavalcanti, Francisco Allysson de Assis Ferreira Gadelha, Louise Mangueira de Lima, Adriano Francisco Alves, Cláudio Gabriel Lima Júnior, Marcia Regina Piuvezam
Combined allergic rhinitis and asthma syndrome (CARAS) is an airway-type 2 immune response with a profuse inflammatory process widely affecting the world population. Due to the compromise of quality of life and the lack of specific pharmacotherapy, the search for new molecules becomes relevant. This study aimed to evaluate the effectiveness of the Morita-Bailys-Hillman adduct (CISACN) treatment in the CARAS experimental model. Female BALB/c mice were ovalbumin (OVA) -sensitized and -challenged and treated with CISACN...
February 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38398384/the-impact-of-thermal-water-in-asthma-and-copd-a-systematic-review-according-to-the-prisma-statement
#23
REVIEW
Luigino Calzetta, Nicola Di Daniele, Alfredo Chetta, Marco Vitale, Shima Gholamalishahi, Mario Cazzola, Paola Rogliani
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are global health challenges leading to substantial morbidity and mortality. While existing guidelines emphasize evidence-based treatments, the potential therapeutic role of thermal water (TW) inhalation remains under-investigated. METHODS: This systematic review followed PRISMA-P guidelines and sought to evaluate the impact of TW in asthma and COPD. A thorough literature search, performed up to May 2023, encompassed in vitro, in vivo, randomized controlled trial (RCT), non-RCT, and observational studies...
February 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38381001/il-33-induces-cellular-and-exosomal-mir-146a-expression-as-a-feedback-inhibitor-of-mast-cell-function
#24
JOURNAL ARTICLE
Marcela T Taruselli, Amina Abdul Qayum, Daniel Abebayehu, Heather L Caslin, Jordan M Dailey, Aditya Kotha, Jason R Burchett, Sydney A Kee, Tania D Maldonado, Boyang Ren, Wei Chao, Lin Zou, Tamara T Haque, David Straus, John J Ryan
IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade suppresses asthma-like inflammation in mouse models. Homeostatic control of IL-33 signaling is poorly understood. Because the IL-33 receptor, ST2, acts via cascades used by the TLR family, similar feedback mechanisms may exist. MicroRNA (miR)-146a is induced by LPS-mediated TLR4 signaling and serves as a feedback inhibitor...
February 21, 2024: Journal of Immunology
https://read.qxmd.com/read/38369009/characterization-and-applicability-of-a-novel-physiologically-relevant-3d-tetraculture-bronchial-model-for-in-vitro-assessment-of-respiratory-sensitization
#25
JOURNAL ARTICLE
Artur Christian Garcia da Silva, Izadora Caroline Furtado de Mendonça, Marize Campos Valadares
Chemical Respiratory Allergy (CRA) is triggered after exposure to Low Molecular Weight (LMW) sensitizers and manifests clinically as asthma and rhinitis. From a risk/toxicity assessment point of view, there are few methods, none of them validated, for evaluating the respiratory sensitization potential of chemicals once the in vivo-based models usually employed for inhalation toxicity addressment do not comprise allergenicity endpoints specifically. Based on that, we developed, characterized, and evaluated the applicability of a 3D-tetraculture airway model reconstructed with bronchial epithelial, fibroblasts, endothelial and monocytic cell lines...
February 16, 2024: Toxicology
https://read.qxmd.com/read/38363325/deficiency-of-inpp4a-promotes-m2-macrophage-polarization-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#26
JOURNAL ARTICLE
Yingying Xu, Xiaoting Tong, Peiqiang Liu, Jingyu Huang, Siyuan Chen, Duo Liu, Tian Gu, Yulie Xie, Duo Guo, Yu Xu
OBJECTIVE: The treatment of eosinophilic chronic rhinosinusitis with nasal polyps (E-CRSwNP) remains a challenge due to its complex pathogenesis. Inositol polyphosphate-4-phosphatase type IA (INPP4A), a lipid phosphatase, has been implicated in allergic asthma. However, the expression and function of INPP4A in E-CRSwNP remain unclear. This study aims to investigate the role of INPP4A in macrophages in E-CRSwNP. METHODS: We assessed the expression of INPP4A in human and mouse nasal mucosal tissues via immunofluorescence staining...
February 16, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38354337/the-impact-of-different-data-handling-strategies-in-exploratory-and-confirmatory-factor-analysis-of-diary-measures-an-evaluation-using-simulated-and-real-world-asthma-nighttime-symptoms-diary-data
#27
JOURNAL ARTICLE
Gerasimos Dumi, Dara O'Neill, Christina Daskalopoulou, Tom Keeley, Stephanie Rhoten, Dharmraj Sauriyal, Piper Fromy
BACKGROUND: Daily diaries are an important modality for patient-reported outcome assessment. They typically comprise multiple questions, so understanding their underlying structure is key to appropriate analysis and interpretation. Structural evaluation of such measures poses challenges due to the high volume of repeated measurements. Potential strategies include selecting a single day, averaging item-level observations over time, or using all data while accounting for its multilevel structure...
February 14, 2024: Journal of Biopharmaceutical Statistics
https://read.qxmd.com/read/38335181/a-targeted-amplicon-next-generation-sequencing-assay-for-tryptase-genotyping-to-support-personalized-therapy-in-mast-cell-related-disorders
#28
JOURNAL ARTICLE
Olga Li, Jason A Hackney, David F Choy, Diana Chang, Rhea Nersesian, Tracy L Staton, Fang Cai, Shadi Toghi Eshghi
Tryptase, the most abundant mast cell granule protein, is elevated in severe asthma patients independent of type 2 inflammation status. Higher active β tryptase allele counts are associated with higher levels of peripheral tryptase and lower clinical benefit from anti-IgE therapies. Tryptase is a therapeutic target of interest in severe asthma and chronic spontaneous urticaria. Active and inactive allele counts may enable stratification to assess response to therapies in asthmatic patient subpopulations...
2024: PloS One
https://read.qxmd.com/read/38324020/participant-perspectives-on-the-implementation-of-a-school-linked-text-message-intervention-to-improve-pediatric-asthma-medication-adherence
#29
JOURNAL ARTICLE
Sonia Radu, Sheerin Zarinafsar, Grace W Ryan, Sanjay Chainani, Sarah Becker, Juliana Arenas, Michelle A Spano, Holly N Shillan, Shushmita Hoque, Rajani Sadasivam, Lori Pbert, Janki Luther, Michelle K Trivedi
Background: Poor adherence to inhaled corticosteroids (ICS) is a significant challenge in pediatric asthma, contributing to health inequities. Text-message reminders for ICS therapy are an evidence-based approach that improves pediatric asthma medication adherence, yet has not been widely adopted into practice, partly due to lack of (1) participant input on design and implementation and (2) use of sustainable community linkages. Remote Asthma Link™ (RAL) seeks to fill this gap as a school-linked text-message intervention wherein parents of children with poorly controlled asthma received daily, 2-way text-message reminders for preventive inhaler use...
February 7, 2024: Pediatric Allergy, Immunology, and Pulmonology
https://read.qxmd.com/read/38316671/mesenchymal-stromal-cell-therapy-alleviates-ovalbumin-induced-chronic-airway-remodeling-by-suppressing-m2-macrophage-polarization
#30
JOURNAL ARTICLE
Haiyang Yu, Guiyin Zhu, Qiangqiang Qin, Xueting Wang, Xuejun Guo, Wen Gu
Chronic asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Previous studies have shown that mesenchymal stromal/stem cells (MSCs) exert anti-inflammatory effects on asthma via regulation of the immune cells. However, the therapeutic mechanism of MSCs, especially the mechanism of airway remodeling in chronic asthma, remains to be elucidated. Here, we aimed to investigate the therapeutic effect of MSCs on airway remodeling in chronic asthma and explored the mechanisms by analyzing the polarization phenotype of macrophages in the lungs...
February 6, 2024: Inflammation
https://read.qxmd.com/read/38310765/radical-s-adenosyl-methionine-domain-containing-2-a-potential-target-of-d-tryptophan-in-asthma-treatment-regulates-t-helper-cell-type-1-2-balance
#31
JOURNAL ARTICLE
Fei Wang, Yunxiao Shang
Asthma is a common chronic respiratory disease. D-tryptophan (D-TRP) can inhibit allergic airway inflammation and T helper cell type 2 (Th2) immune response. RNA-sequencing results have indicated that radical S-adenosyl methionine domain-containing 2 (RSAD2) might be a potential molecular target of D-TRP in asthma treatment. Herein, we established a mouse model of asthma using ovalbumin (OVA) via intraperitoneal injection and inhalational challenge. Gain- and loss-of-function studies of RSAD2 were performed in mice following the intratracheal delivery of lentiviral vectors (3 × 106 TU/mL)...
February 3, 2024: International Immunopharmacology
https://read.qxmd.com/read/38310669/anti-inflammation-of-lztfl1-knockdown-in-ova-induced-asthmatic-mice-through-erk-gata3-signaling-pathway
#32
JOURNAL ARTICLE
Guihua Song, Mengmeng Sun, Yan Zhang, Bingxue Zhang, Minghao Peng, Beibei Bao
Asthma is a common chronic respiratory disease characterized by Th2-type inflammation in the airways. Leucine zip transcription factor-like 1 (LZTFL1) has been implicated in the regulation of Th2-related factors. The knockdown of LZTFL1 resulted in decreased levels of IL-4, IL-5, and IL-13. We hypothesize that LZTFL1 may have an effect on asthma. We established an acute asthmatic mouse model using the Ovalbumin (OVA) sensitization, and we found that LZTFL1 expression was upregulated in OVA-induced CD4 + T cells...
February 3, 2024: Molecular Immunology
https://read.qxmd.com/read/38299353/modulation-by-withania-somnifera-of-stress-induced-anxiogenesis-and-airway-inflammation-in-rats
#33
JOURNAL ARTICLE
Sana Rehman, Maaz Naqvi, Nafaa Hasan Ali, Kavita Gulati, Arunabha Ray
OBJECTIVES: Stress is an aversive stimulus which disrupts the biological milieu of the organism and a variety of emotional and environmental stressors are known to influence allergic and immunological disorders like bronchial asthma but the pharmacological basis of such interactions is not clearly defined. Withania somnifera (ashwagandha) is a potent anti-stress agent used widely in Indian traditional medicine and the present experimental study evaluated the effects of W. somnifera extract (WSE) on chronic stress-induced neurobehavioral and immunological responses in an experimental model of allergic asthma in rats...
February 1, 2024: Journal of Complementary & Integrative Medicine
https://read.qxmd.com/read/38290992/sphingosine-kinase-1-specific-inhibitor-pf543-reduces-goblet-cell-metaplasia-of-bronchial-epithelium-in-an-acute-asthma-model
#34
JOURNAL ARTICLE
Tara Sudhadevi, Steven J Ackerman, Anjum Jafri, Prathima Basa, Alison W Ha, Viswanathan Natarajan, Anantha Harijith
Sphingosine kinase 1 (SPHK1) has been shown to play a key role in the pathogenesis of asthma where SPHK1 generated S1P is known to mediate innate and adaptive immunity while promoting mast cell degranulation. Goblet cell metaplasia (GCM) contributes to airway obstruction in asthma and has been demonstrated in animal models. We investigated the role of PF543, a SPHK1 specific inhibitor, in preventing the pathogenesis of GCM using a murine (C57BL/6) model of allergen-induced acute asthma. Treatment with PF543 prior to triple allergen exposure (DRA: House dust mite, Ragweed pollen and Aspergillus) reduced inflammation, eosinophilic response, and GCM followed by reduced airway hyperreactivity to intravenous methacholine...
January 30, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/38286741/anti-inflammatory-effects-of-reticuline-on-the-jak2-stat3-socs3-and-p38-mapk-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-mouse-model-of-obesity-associated-asthma
#35
JOURNAL ARTICLE
Xiaojiang Lyu, Jiaojiao Liu, Zengrong Liu, Ying Wu, Ping Zhu, Chonghai Liu
BACKGROUND: Asthma associated with obesity is a chronic disease characterized by earlier airway remodeling, severe wheezing, and increased insensitivity to hormone therapy. Reticuline, a bioactive compound of Magnoliae Flos, exerts anti-inflammatory activity and can inhibit neutrophil recruitment. Thus, this study investigated the role of reticuline in obesity-related asthma. METHODS: The BALB/c mice fed a low-fat diet (LFD) and high-fat diet (HFD) were intranasally challenged with house dust mites (HDMs) or ovalbumin (OVA)...
January 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38273268/unveiling-the-potent-effect-of-vitamin-d-harnessing-nrf2-ho-1-signaling-pathways-as-molecular-targets-to-alleviate-urban-particulate-matter-induced-asthma-inflammation
#36
JOURNAL ARTICLE
Dandan Ge, Qihong Chen, Xiaohua Xie, Qiyuan Li, Yungang Yang
BACKGROUND: Asthma is the most common allergic disease characterized by an inflammatory response in the airways. Mechanismly, urban particulate matter (PM) is the most widely air pollutant associated with increased asthma morbidity and airway inflammation. Current research found that vitamin D is an essential vitamin with anti-inflammatory, antioxidant and other medical efficacy. Inadequate or deficient vitamin D often leads to the pathogenesis and stability of asthma. NGF exacerbates airway inflammation in asthma by promoting smooth muscle cell proliferation and inducing the Th2 immune response...
January 25, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38268004/asthma-prediction-via-affinity-graph-enhanced-classifier-a-machine-learning-approach-based-on-routine-blood-biomarkers
#37
JOURNAL ARTICLE
Dejing Li, Stanley Ebhohimhen Abhadiomhen, Dongmei Zhou, Xiang-Jun Shen, Lei Shi, Yubao Cui
BACKGROUND: Asthma is a chronic respiratory disease affecting millions of people worldwide, but early detection can be challenging due to the time-consuming nature of the traditional technique. Machine learning has shown great potential in the prompt prediction of asthma. However, because of the inherent complexity of asthma-related patterns, current models often fail to capture the correlation between data samples, limiting their accuracy. Our objective was to use our novel model to address the above problem via an Affinity Graph Enhanced Classifier (AGEC) to improve predictive accuracy...
January 24, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38264188/the-impact-of-chronic-disease-diagnoses-on-smoking-behavior-change-and-maintenance-evidence-from-china
#38
JOURNAL ARTICLE
Xinxin Chi, Xihua Liu, Cong Li, Wen Jiao
INTRODUCTION: Managing chronic diseases and tobacco use is a formidable challenge in low- and middle-income countries (LMICs) with limited health literacy and access to quality healthcare. This study examines the empirical evidence from China, utilizing quasi-experimental approaches to assess the causal effect of chronic disease diagnoses on smoking behavior. METHODS: Employing the diagnosis of chronic disease in the older cohorts of the population as a natural experiment, this study utilizes recent advancements in difference-in-difference estimation methods (CS-DID) to investigate the effect of a diagnosis on smoking behavior...
2024: Tobacco Induced Diseases
https://read.qxmd.com/read/38262390/novel-artificial-intelligence-based-technology-to-diagnose-asthma-using-methacholine-challenge-tests
#39
JOURNAL ARTICLE
Noeul Kang, KyungHyun Lee, Sangwon Byun, Jin-Young Lee, Dong-Chull Choi, Byung-Jae Lee
PURPOSE: The methacholine challenge test (MCT) has high sensitivity but relatively low specificity for asthma diagnosis. This study aimed to develop and validate machine learning (ML) models to improve the diagnostic performance of MCT for asthma. METHODS: Data from 1,501 patients with asthma symptoms who underwent MCT between 2015 and 2020 were analyzed. The patients were grouped as either the training (80%, n = 1,265) and test sets (20%, n = 236) depending on the time of referral...
January 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38261955/long-non-coding-rna-lncrna-non-coding-rna-activated-by-dna-damage-norad-knockdown-alleviates-airway-remodeling-in-asthma-via-regulating-mir-410-3p-rcc2-and-inhibiting-wnt-%C3%AE-catenin-pathway
#40
JOURNAL ARTICLE
Ting Zhang, Han Huang, Lihong Liang, Hongxia Lu, Dongge Liang
BACKGROUND: Asthma is a chronic inflammatory disorder with high prevalence in childhood. Airway remodeling, an important structural change of the airways, is resulted from epithelial-mesenchymal transition. Long non-coding RNA non-coding RNA activated by DNA damage (NORAD) has been found to promote epithelial-mesenchymal transition in multiple cancers. This study aimed to analyze the role of NORAD in asthma, mainly focusing on epithelial-mesenchymal transition-mediated airway remodeling, and further explored the NORAD-miRNA-mRNA network...
January 15, 2024: Heliyon
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