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Asthma challenge model

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https://www.readbyqxmd.com/read/28742120/virus-induced-asthma-attack-the-importance-of-allergic-inflammation-in-response-to-viral-antigen-in-an-animal-model-of-asthma
#1
Christopher Skappak, Ramses Ilarraza, Ying-Qi Wu, Matthew G Drake, Darryl J Adamko
Asthma exacerbation can be a life-threatening condition, and is most often triggered by common respiratory viruses. Poor asthma control and worsening of respiratory function is associated with increased airway inflammation, including eosinophilia. Prevention of asthma exacerbation relies on treatment with corticosteroids, which preferentially inhibit allergic inflammation like eosinophils. Human studies demonstrate that inactivated virus can trigger eosinophil activation in vitro through antigen presentation and memory CD4+ lymphocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28736267/gamma-tocopherol-enriched-supplement-reduces-sputum-eosinophilia-and-endotoxin-induced-sputum-neutrophilia-in-volunteers-with-asthma
#2
Allison J Burbank, Charity G Duran, Yinghao Pan, Patricia Burns, Susan Jones, Qing Jiang, Chao Yang, Sha'Leema Jenkins, Heather Wells, Neil Alexis, Mehmet Kesimer, William D Bennett, Haibo Zhou, David B Peden, Michelle L Hernandez
BACKGROUND: We and others have shown that the gamma tocopherol (γT) isoform of vitamin E has multiple anti-inflammatory and antioxidant actions and that γT supplementation reduces eosinophilic and endotoxin (LPS)-induced neutrophilic airway inflammation in animal models and healthy human volunteers. OBJECTIVE: To determine if γT supplementation reduces eosinophilic airway inflammation and acute neutrophilic response to inhaled LPS challenge in volunteers with asthma...
July 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28732802/carica-papaya-ameliorates-allergic-asthma-via-down-regulation-of-il-4-il-5-eotaxin-tnf-%C3%AE-nf-%C3%A4-b-and-inos-levels
#3
Asma Inam, Muhammad Shahzad, Arham Shabbir, Hira Shahid, Khadija Shahid, Aqeel Javeed
BACKGROUND: Natural products have a prime importance as an essential source for new drug discovery. Carica papaya leaves (CPL) have been used to treat inflammation in traditional system of medicine. AIM/HYPOTHESIS: Current study evaluates the anti-inflammatory and immunomodulatory effects of CPL extract using mouse model of ovalbumin- (OVA) induced allergic asthma. METHODS: All the mice were intraperitoneally sensitized and subsequently given intranasal challenge with OVA except the control group...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28729731/anti-asthmatic-effect-of-pitavastatin-through-aerosol-inhalation-is-associated-with-cd4-cd25-foxp3-t-cells-in-an-asthma-mouse-model
#4
Songquan Wu, Ruhui Yang, Guangli Wang
Statins are competitive inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-A) reductase, and studies have shown that statins also have anti-inflammatory and immunomodulatory properties. The purpose of this study was to investigate the anti-asthmatic effects of pitavastatin, a type of statin, in an asthma mouse model. Mice were sensitized and challenged with ovalbumin (OVA) to establish the asthma model. These mice were then treated with inhaled pitavastatin (5 mg/kg) or dexamethasone (2 mg/kg), the latter of which served as a positive control...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727997/therapeutic-intranasal-instillation-of-allergen-loaded-microbubbles-suppresses-experimental-allergic-asthma-in-mice
#5
Blaise Corthésy, Gilles Bioley
Despite proven efficiency, subcutaneous immunotherapy for aeroallergens is impaired by the duration of the protocol, the repeated injections and potential side-effects associated with the doses of allergen administered. Intranasal delivery of immunotherapeutic agents may overcome several of these drawbacks, provided that an efficient allergen delivery vehicle can be identified. This study evaluates whether intranasally delivered gas-filled microbubble (MB)-associated ovalbumin (OVA), used as a model allergen, can serve as a therapeutic treatment in a mouse model of established allergic asthma...
July 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28725641/mechanisms-mediating-pediatric-severe-asthma-and-potential-novel-therapies
#6
REVIEW
Aldara Martin Alonso, Sejal Saglani
Although a rare disease, severe therapy-resistant asthma in children is a cause of significant morbidity and results in utilization of approximately 50% of health-care resources for asthma. Improving control for children with severe asthma is, therefore, an urgent unmet clinical need. As a group, children with severe asthma have severe and multiple allergies, steroid resistant airway eosinophilia, and significant structural changes of the airway wall (airway remodeling). Omalizumab is currently the only add-on therapy that is licensed for use in children with severe asthma...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28713373/15-deoxy-delta-12-14-prostaglandin-j2-inhibits-lung-inflammation-and-remodeling-in-distinct-murine-models-of-asthma
#7
Diego S Coutinho, Edna A Anjos-Valotta, Caio V M F do Nascimento, Ana Lucia A Pires, Marcelo H Napimoga, Vinícius F Carvalho, Rafael C Torres, Patrícia M R E Silva, Marco A Martins
15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ2 based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA) or house dust mite extract (HDM). Characteristics of lung inflammation, airway hyper-reactivity (AHR), mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ2 were assessed...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28709839/fungal-immunomodulatory-protein-fve-could-modulate-airway-remodel-through-by-affect-il17-cytokine
#8
Yu-Tzu Lee, Chia-Ta Wu, Hai-Lun Sun, Jiunn-Liang Ko, Ko-Haung Lue
BACKGROUND: Asthma is one of the most common allergic diseases. Our previous studies have reported that FIP-fve in acute allergic mouse model can reduce inflammation, improve the balance of the Th1/Th2 system. However, the effects of reducing airway remodeling on FIP-fve is still unknown. OBJECTIVE: We hypothesized that orally administrated FIP-fve should be able to reduce airway remodeling in chronic allergic models. METHODS: The chronic asthma animal model was established with 6-8 weeks female Balb/c mice...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28704401/il-13-is-a-central-mediator-of-chemical-induced-airway-hyperreactivity-in-mice
#9
Fien C Devos, Lore Pollaris, Jonathan Cremer, Sven Seys, Tomoaki Hoshino, Jan Ceuppens, Karel Talavera, Benoit Nemery, Peter H M Hoet, Jeroen A J Vanoirbeek
BACKGROUND: While the importance of the Th2 cytokine IL-13 as a central mediator of airway hyperreactivity (AHR) has been described in allergic protein-induced asthma, this has never been investigated in chemical-induced asthma. OBJECTIVE: We examined the importance of IL-13 in a mouse model of chemical-induced AHR, using toluene-2,4-diisocyanate (TDI). METHODS: In a first set-up, wild type (WT) and IL-13 knockout (KO) C57Bl/6 mice were dermally treated on days 1 and 8 with 1% TDI or vehicle (acetone/olive oil) on both ears...
2017: PloS One
https://www.readbyqxmd.com/read/28700253/house-dust-mite-induced-allergic-airway-disease-is-independent-of-ige-and-fc%C3%A9-ri%C3%AE
#10
Christopher G McKnight, Joseph A Jude, Zhenqi Zhu, Reynold A Panettieri, Fred D Finkelman
IgE contributes to disease exacerbations but not to baseline airway hyperresponsiveness (AHR) in human asthma. In rodent allergic airway disease (AAD), mast cell and IgE dependence for the induction of AHR has only been observed when mice are immunized with a relatively weak allergen without adjuvant. To evaluate the role of IgE in murine AAD that is induced by a potent allergen, we inoculated BALB/c and FVB/N background wild-type, and IgE- or FcεRIα-deficient mice intratracheally with large or limiting doses of house dust mite extract (HDM) and evaluated AHR, pulmonary eosinophilia, goblet cell metaplasia, serum IgE, and lung mastocytosis...
July 12, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28697062/morbidity-and-health-risk-factors-among-new-mexico-miners-a-comparison-across-mining-sectors
#11
Alice M Shumate, Kristin Yeoman, Tristan Victoroff, Kandace Evans, Roger Karr, Tami Sanchez, Akshay Sood, Anthony Scott Laney
OBJECTIVE: This study examines differences in chronic health outcomes between coal, uranium, metal, and nonmetal miners. METHODS: In a cross-sectional study using data from a health screening program for current and former New Mexico miners, log-binomial logistic regression models were used to estimate relative risks of respiratory and heart disease, cancer, osteoarthritis, and back pain associated with mining in each sector as compared with coal, adjusting for other relevant risk factors...
July 10, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28696809/effects-of-aspergillus-fumigatus-on-glucocorticoid-receptor-and-%C3%AE-2-adrenergic-receptor-expression-in-a-rat-model-of-asthma
#12
Xia Zhou, Ya-Jie Dang, Gui-Fang Wang, Xian-Qiao Jin
PURPOSE: Conventional inhaled corticosteroids or β2-adrenergic receptor agonists do not work well in some asthmatic populations while empirical antifungal therapy has obvious impact on those patients. The study was designed to investigate whether short-term exposure to Aspergillus fumigatus (A. fumigatus) could decrease glucocorticoid receptor (GCR) and β2-adrenergic receptor (ADRB2) expression in lung tissue of asthmatic rats. MATERIALS AND METHODS: A rat model of chronic asthma was first established by ovalbumin sensitization and challenge...
July 11, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28696800/effect-of-nintedanib-on-airway-inflammation-and-remodeling-in-a-murine-chronic-asthma-model
#13
Hwa Young Lee, Jung Hur, In Kyoung Kim, Ji Young Kang, Hyoung Kyu Yoon, Sook Young Lee, Soon Suk Kwon, Young Kyoon Kim, Chin Kook Rhee
INTRODUCTION: Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis is a key process involved in airway structural changes in patients with bronchial asthma, the effect of nintedanib targeting the angiokinase pathway on airway inflammation and remodeling has not been evaluated. METHODS: We used a 3-month ovalbumin (OVA) challenge mouse model of airway remodeling. Nintedanib was orally administrated during the challenge period, and the effects were examined based on the percentage of airway inflammatory cells, airway hyper-reactivity (AHR), peribronchial goblet cell hyperplasia, total lung collagen and smooth muscle area...
July 11, 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28689020/ferulic-acid-supresses-th2-immune-response-and-prevents-remodeling-in-ovalbumin-induced-pulmonary-allergy-associated-with-inhibition-of-epithelial-derived-cytokines
#14
Alessa Sin Singer Brugiolo, Ana Cláudia Carvalho Gouveia, Caio César de Souza Alves, Flávia Márcia de Castro E Silva, Érick Esteves de Oliveira, Ana Paula Ferreira
Asthma is characterized by intermittent airway obstruction and chronic inflammation, orchestrated primarily by Th2 cytokines. There is a strong rationale for developing new asthma therapies, since current treatment protocols present side effects and may not be effective in cases of difficult-to-control asthma. The purpose of this study was to evaluate the effect of ferulic acid, a phenolic acid commonly present in plants, in the ovalbumin-induced pulmonary allergy murine model. METHODS: BALB/c mice were sensitized and challenged with ovalbumin, and treatments were provided by gavage...
July 5, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28687462/the-effect-of-tiotropium-in-combination-with-olodaterol-on-house-dust-mite-induced-allergic-airway-disease
#15
Gerrit John-Schuster, Stan de Kleijn, Yolanda van Wijck, Veerle Kremer, Hermelijn H Smits, Michael P Pieper, Pieter S Hiemstra, Christian Taube
One of the major goals of asthma therapy is to maintain asthma control and prevent acute exacerbations. Long-acting bronchodilators are regularly used for the treatment of asthma patients and in clinical studies the anti-cholinergic tiotropium has recently been shown to reduce exacerbations in patients with asthma. So far it is unclear how tiotropium exerts this effect. For this purpose, we designed an allergen-driven rechallenge model of allergic airway inflammation in mice, to assess the effectiveness of tiotropium and the long-acting β-2 adrenoceptor agonist olodaterol on allergen-induced exacerbations of airway disease...
July 4, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28680328/anti-allergic-effect-of-luteolin-in-mice-with-allergic-asthma-and-rhinitis
#16
Tae Young Jang, Ah-Yeoun Jung, Tae-Suk Kyung, Dae-Young Kim, Jun-Ha Hwang, Young Hyo Kim
AIM OF THE STUDY: We aimed to evaluate the anti-allergic effect of luteolin treatment in mice with allergic asthma and rhinitis. MATERIAL AND METHODS: Thirty-two BALB/c mice (n = 8 for each group) were used. Mice in group A (nonallergic group) were exposed to saline, while those in Group B (allergic group) were exposed to ovalbumin (OVA) intraperitoneal (i.p.) injection and intranasal (i.n.) challenge. Null treatment group (Group C) received sterile saline (150 μl) i...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28678189/reduction-of-asthmatic-parameters-by-sea-hare-hydrolysates-in-a-mouse-model-of-allergic-asthma
#17
Ji Hyeon Ryu, Chengliang Xie, Eun-Jin Kim, Si-Hyang Park, Yeung Joon Choi, Sang Soo Kang, Min-Kyoung Shin, Dawon Kang
Sea hare has a variety of biological activities. However, little is known regarding the anti-asthmatic effects of sea hare. This study was performed to identify the effect of sea hare hydrolysates (SHH) on an ovalbumin (OVA)-induced allergic asthma model. The experimental asthma model was sensitized and challenged with OVA. We found that a high-dose of SHH (HSHH) significantly inhibited OVA-induced airway inflammation and mucus production around the airway in lung sections, while low- and medium-dose SHH showed an insignificant effect...
July 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28670318/cigarette-smoke-increases-cd8%C3%AE-dendritic-cells-in-an-ovalbumin-induced-airway-inflammation
#18
Thayse Regina Brüggemann, Paula Fernandes, Luana de Mendonça Oliveira, Maria Notomi Sato, Mílton de Arruda Martins, Fernanda Magalhães Arantes-Costa
Asthma is an allergic lung disease and, when associated to cigarette smoke exposition, some patients show controversial signs about lung function and other inflammatory mediators. Epidemiologic and experimental studies have shown both increasing and decreasing inflammation in lungs of subjects with asthma and exposed to cigarette smoke. Therefore, in this study, we analyzed how cigarette smoke affects pro-inflammatory and anti-inflammatory mediators in a murine model of allergic pulmonary inflammation. We sensitized Balb/c mice to ovalbumin (OVA) with two intraperitoneal injections...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28656964/il-33-promotes-gastrointestianl-allergy-in-a-tslp-independent-manner
#19
H Han, F Roan, L K Johnston, D E Smith, P J Bryce, S F Ziegler
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tested the functional role of IL-33 and the interplay between IL-33 and TSLP in mouse models of atopic march and gastrointestinal (GI) allergy...
June 28, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28656903/association-of-extended-nitric-oxide-parameters-with-bronchial-hyperresponsiveness-and-bronchodilator-response-in-children-with-asthma
#20
Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Min Jung Kim, Kyung Won Kim, Myunghyun Sohn, Kyu-Earn Kim
Theoretical non-linear modeling of exhaled nitric oxide has revealed extended flow-independent parameters that could explain where or how nitric oxide is produced in the lung and transferred to the airway gas stream. We aimed to evaluate the associations of bronchial hyperresponsiveness and bronchodilator response with extended flow-independent nitric oxide parameters. Nitric oxide (30, 50, 100, 200 mL/s) was measured in 432 children with asthma on the same day as either methacholine challenge test (n=156) or spirometry with bronchodilator (n=276; 96 previously diagnosed with asthma and treated with inhaled corticosteroid, 37 with acute exacerbation treated with systemic corticosteroid)...
June 28, 2017: Journal of Breath Research
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