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Asthma challenge model

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https://www.readbyqxmd.com/read/28915873/a-prospective-cohort-study-on-ambient-air-pollution-and-respiratory-morbidities-including-childhood-asthma-in-adolescents-from-the-western-cape-province-study-protocol
#1
Toyib Olaniyan, Mohamed Jeebhay, Martin Röösli, Rajen Naidoo, Roslynn Baatjies, Nino Künzil, Ming Tsai, Mark Davey, Kees de Hoogh, Dilys Berman, Bhawoodien Parker, Joy Leaner, Mohamed Aqiel Dalvie
BACKGROUND: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28910960/-effects-of-human-mesenchymal-stem-cells-on-airway-inflammation-in-allergic-asthma-mice-and-the-underlying-mechanism
#2
N N Ren, H J Chen, Q L Chen, J Eileen, Y G An, Yiguang Lin
Objectives: To investigate the effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on airway inflammation in an ovalbumin (OVA) induced asthma mouse model and the underlying mechanism. Methods: Twenty-four BALB/c mice were randomly divided into four equal groups: normal control group, OVA-induced asthmatic model group, hUC-MSCs treated group (50 μl of hUC-MSCs was transplanted into the trachea of asthmatic mice ) and hUC-MSCs control group (50 μl of hUC-MSCs was transplanted into the trachea of control mice)...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28899934/bronchial-hyperresponsiveness-and-obesity-in-middle-age-insights-from-an-australian-cohort
#3
John A Burgess, Melanie C Matheson, Fei Diao, David P Johns, Bircan Erbas, Adrian J Lowe, Lyle C Gurrin, Caroline J Lodge, Paul S Thomas, Stephen Morrison, Bruce R Thompson, Iain Feather, Jennifer L Perret, Michael J Abramson, Graham G Giles, John L Hopper, Shyamali C Dharmage, Eugene H Walters
The association between obesity and bronchial hyperresponsiveness (BHR) is incompletely characterised. Using the 2006 follow-up of the Tasmanian Longitudinal Health Study, we measured the association between obesity and BHR and whether it was mediated by small airway closure or modified by asthma and sex of the patient.A methacholine challenge measured BHR. Multivariable logistic regression measured associations between body mass index (BMI) and BHR, adjusting for sex, asthma, smoking, corticosteroid use, family history and lung function...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28894452/raw-cow-s-milk-prevents-the-development-of-airway-inflammation-in-a-murine-house-dust-mite-induced-asthma-model
#4
Suzanne Abbring, Kim A T Verheijden, Mara A P Diks, Athea Leusink-Muis, Gert Hols, Ton Baars, Johan Garssen, Betty C A M van Esch
Epidemiological studies show an inverse relation between raw cow's milk consumption and the development of asthma. This protective effect seems to be abolished by milk processing. However, evidence for a causal relationship is lacking, and direct comparisons between raw and processed milk are hardly studied. Therefore, this study investigated the preventive capacity of raw and heated raw milk on the development of house dust mite (HDM)-induced allergic asthma in mice. Six- to seven-week-old male BALB/c mice were intranasally (i...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28890402/lung-responses-in-murine-models-of-experimental-asthma-value-of-house-dust-mite-over-ovalbumin-sensitization
#5
Camille Doras, Ferenc Petak, Sam Bayat, Aurélie Baudat, Christophe Von Garnier, Philippe Eigenmann, Walid Habre
Ovalbumin (OVA) sensitization has limitations in modelling asthma. Thus, we examined the value of allergic sensitization using a purified natural allergen, house dust mite (HDM), over the sensitization performed with OVA. Mice were sham-treated, or sensitized with OVA- or HDM with identical chronology. Airway resistance, tissue damping and elastance were assessed under control conditions and after challenging the animals with methacholine (MCh) and the specific allergen. Inflammatory profile of the bronchoalveolar lavage fluid was characterized and lung histology was performed...
September 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28889953/role-of-b-cells-in-t-helper-cell-responses-in-a-mouse-model-of-asthma
#6
Tomasz Piotr Wypych, Roberta Marzi, Gregory F Wu, Antonio Lanzavecchia, Federica Sallusto
BACKGROUND: The importance of B lymphocytes to present antigens for antibody production is well documented. In contrast, very little is known about their capacity to influence CD4(+) T cell activation during primary or secondary response to allergens. OBJECTIVE: Using mouse models of asthma, we investigated the role of B cells as antigen presenting cells in propagation and initiation of T helper cell responses. METHODS: Mice were immunized via intranasal route with house dust mite extract (HDM) derived from Dermatophagoides pteronyssinus...
September 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28888514/indicators-of-non-adherence-to-asthma-treatment-in-pediatric-primary-care
#7
Marcela D Monti, Rose M Nealis
PURPOSE: Chronic disease management represents an ongoing challenge, as many childhood illnesses require complex medical management by primary care providers. Asthma is one such illness, and today there is evidence to support primary care-based management strategies that will benefit patients with asthma throughout a lifetime. This study seeks to find significant indicators of asthma non-adherence in pediatric primary care, with potential for utilization in the medical home model. DESIGN AND METHODS: Potential indicators included in a chart review process of one large Southeastern U...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28886711/structure-and-functional-impact-of-seed-region-variant-in-mir-499-gene-family-in-bronchial-asthma
#8
Eman A Toraih, Mohammad H Hussein, Essam Al Ageeli, Eman Riad, Nouran B AbdAllah, Ghada M Helal, Manal S Fawzy
BACKGROUND: Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at determining the role of microRNA-499 (MIR-499) gene family polymorphism as a marker for susceptibility and progression of bronchial asthma and to analyze the structural and functional impact of rs3746444 within the seed region. METHODS: Genotyping for 192 participants (96 patients and 96 controls) in the discovery phase and 319 subjects (115 patients and 204 controls) in the replication phase was performed via Real Time-Polymerase Chain Reaction technology...
September 8, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28867182/deficiency-of-klf4-compromises-the-lung-function-in-an-acute-mouse-model-of-allergic-asthma
#9
Jeanette A Nimpong, Wintana Gebregziabher, Udai P Singh, Prakash Nagarkatti, Mitzi Nagarkatti, Johnie Hodge, Chunming Liu, Daping Fan, Walden Ai
Asthma is a chronic inflammatory disease of the airways and the mechanisms are not fully understood. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of monocytes, granulocyte and myeloid cells at early stage of differentiation. They possess phenotypic plasticity and regulate airway inflammation. We recently reported that Kruppel-like factor 4 (KLF4) regulates MDSC differentiation into fibrocytes, emerging effectors in chronic inflammation. However, the role of KLF4 in asthma is not known...
August 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28865147/differential-regulation-of-pd-1-and-its-ligands-in-allergic-asthma
#10
Kai Bratke, Linda Fritz, Fabian Nokodian, Kristina Geißler, Katharina Garbe, Marek Lommatzsch, J Christian Virchow
BACKGROUND: Targeting PD-1/PD-1 ligand signalling is an established treatment option for cancer. The role of these molecules in allergic asthma has been investigated in several mouse studies yielding conflicting results. However, human studies investigating the expression and regulation of PD-1 and its ligands in allergic inflammation are lacking. OBJECTIVE: To analyse the expression and regulation of PD-1 and its ligands in human allergic asthma. METHODS: The well-established human asthma model of segmental allergen challenge (SAC) was used to analyse the regulation of PD-1 and its ligands PD-L1 and PD-L2 on T lymphocytes and dendritic cells by flow cytometry...
September 2, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28855674/src-dependent-egfr-transactivation-regulates-lung-inflammation-via-downstream-signaling-involving-erk1-2-pi3k%C3%AE-akt-and-nf%C3%AE%C2%BAb-induction-in-a-murine-asthma-model
#11
Ahmed Z El-Hashim, Maitham A Khajah, Waleed M Renno, Rhema S Babyson, Mohib Uddin, Ibrahim F Benter, Charles Ezeamuzie, Saghir Akhtar
The molecular mechanisms underlying asthma pathogenesis are poorly characterized. In this study, we investigated (1) whether Src mediates epidermal growth factor receptor (EGFR) transactivation; (2) if ERK1/2, PI3Kδ/Akt and NF-κB are signaling effectors downstream of Src/EGFR activation; and (3) if upstream inhibition of Src/EGFR is more effective in downregulating the allergic inflammation than selective inhibition of downstream signaling pathways. Allergic inflammation resulted in increased phosphorylation of EGFR, Akt, ERK1/2 and IκB in the lung tissues from ovalbumin (OVA)-challenged BALB/c mice...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851744/identification-of-trans%C3%A2-protein-qtl-for-secreted-airway-mucins-in-mice-and-a-causal-role-for-bpifb1
#12
Lauren J Donoghue, Alessandra Livraghi-Butrico, Kathryn M McFadden, Joseph M Thomas, Gang Chen, Barbara R Grubb, Wanda K O'Neal, Richard C Boucher, Samir N P Kelada
Mucus hyper-secretion is a hallmark feature of asthma and other muco-obstructive airway diseases. The mucin proteins MUC5AC and MUC5B are the major glycoprotein components of mucus and have critical roles in airway defense. Despite the biomedical importance of these two proteins, the loci that regulate them in the context of natural genetic variation have not been studied. To identify genes that underlie variation in airway mucin levels, we performed genetic analyses in founder strains and incipient lines of the Collaborative Cross (CC) in a house dust mite mouse model of asthma...
August 29, 2017: Genetics
https://www.readbyqxmd.com/read/28843179/propofol-inhibits-nf-%C3%AE%C2%BAb-activation-to-ameliorate-airway-inflammation-in-ovalbumin-ova-induced-allergic-asthma-mice
#13
Qiong Zhang, Liangrong Wang, Baihui Chen, Qian Zhuo, Caiying Bao, Lina Lin
Propofol, one of the most commonly used intravenous anesthetic agents, has been reported to have anti-inflammatory property. However, the anti-allergic inflammation effect of propofol and its underlying molecular mechanisms have not been elucidated. In the present study, we aim to investigate the roles of NF-kB activation in propofol anti-asthma effect on OVA-induced allergic airway inflammation in mice. In a standard experimental asthma model, Balb/c mice were sensitized with ovalbumin, treated with propofol (50,100,150mg/kg) or a vehicle control 1h before OVA challenge...
August 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28835901/beneficial-effects-of-prebiotic-saccharomyces-cerevisiae-mannan-on-allergic-asthma-mouse-models
#14
D Betty Lew, Christie F Michael, Tracie Overbeck, W Scout Robinson, Erin L Rohman, Jeffrey M Lehman, Jennifer K Patel, Brandi Eiseman, Kim S LeMessurier, Amali E Samarasinghe, M Waleed Gaber
One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. The mannose receptor (MR) family plays an important role in allergen uptake and processing of major allergens Der p 1 and Fel d 1. We have previously reported that ASM cells express a mannose receptor (ASM-MR) and that mannan derived from Saccharomyces cerevisiae (SC-MN) inhibits mannosyl-rich lysosomal hydrolase-induced bovine ASM cell proliferation. Using a humanized transgenic mouse strain (huASM-MRC2) expressing the human MRC2 receptor in a SM tissue-specific manner, we have demonstrated that ASM hyperplasia/hypertrophy can occur as early as 15 days after allergen challenge in this mouse model and this phenomenon is preventable with SC-MN treatment...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28812277/milonine-an-alkaloid-of-cissampelos-sympodialis-eichl-menispermaceae-inhibits-histamine-release-of-activated-mast-cells
#15
Adriano Francisco Alves, Giciane Carvalho Vieira, Francisco Allysson A F Gadelha, Luiz Henrique Agra Cavalcante-Silva, Marco Aurélio Martins, José Maria Barbosa-Filho, Marcia Regina Piuvezam
Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions. Previously, several alkaloids were isolated from its roots and leaves with pharmacological properties in asthma and acute inflammation models. Therefore, the aim of this study was to evaluate the milonine effect on mast cells degranulation in vivo and in vitro. Swiss mice (n = 8) were used in models of paw edema induced by carrageenan, compound 48/80, or histamine...
August 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28810548/effect-of-follicular-helper-t-cells-on-the-pathogenesis-of-asthma
#16
Xiaojuan Ma, Zhan Sun, Pei Zhai, Wenyan Yu, Ting Wang, Fengsen Li, Jianbing Ding
Follicular helper T (TFH) cells are considered to be a separate T helper cell subset, specifically to help memory B cell participate in humoral immunity. It has been reported that there is an association between the imbalance of TFH function and certain autoimmune diseases. However, to the best of our knowledge, the effect of TFH cells on the process of bronchial asthma has not been investigated. The aim of the present study was to investigate the associated markers of TFH cells in bronchial asthma-induced mice...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28801844/brg1-inhibits-e-cadherin-expression-in-lung-epithelial-cells-and-disrupts-epithelial-integrity
#17
Ting Wang, Wenjing Zou, Chao Niu, Fengxia Ding, Yaping Wang, Shuang Cai, Hua Zhu, Daiyin Tian, Jihong Dai, Enmei Liu, Qing Lu, Zhou Fu, Lin Zou
Brahma-related gene-1 (Brg1), a key chromatin remodeling factor, is associated with cell proliferation and migration in kidney and heart cells, but few reports have examined its role in airway epithelial cell. Airway epithelial injury, which is involved in the entire pathological process of asthma, is an important cause of recurrent asthma. Here, we studied the function of Brg1 in an ovalbumin (OVA)-induced asthma model (lung-specific conditional Brg1 (Brg1(-/-)) knockdown mice) and human bronchial epithelial 16HBE cells stably expressing Brg1 shRNA...
August 11, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28798203/peripheral-ventilation-heterogeneity-determines-the-extent-of-bronchoconstriction-in-asthma
#18
Catherine E Farrow, Cheryl M Salome, Benjamin E Harris, Dale L Bailey, Norbert Berend, Gregory G King
In asthma, bronchoconstriction causes topographically heterogeneous airway narrowing, as measured by 3-dimensional ventilation imaging. Computation modelling suggests that peripheral airway dysfunction is a potential determinant of acute airway narrowing measured by imaging. We hypothesised that the development of low ventilation regions measured topographically by 3-dimensional imaging after bronchoconstriction is predicted by peripheral airway function. Fourteen (14) asthmatic subjects underwent ventilation Single Photon Emission Computed Tomography/CT (VSPECT/CT) before and after methacholine challenge...
August 10, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28776450/pharmacological-modulation-of-reactive-oxygen-species-ros-improves-the-airway-hyperresponsiveness-by-shifting-the-th1-response-in-allergic-inflammation-induced-by-ovalbumin
#19
Renata Tiscoski Nesi, Marina Valente Barroso, Valdirene de Souza Muniz, Ana Carolina de Arantes, Marco Aurélio Martins, Lycia de Brito Gitirana, Josiane Sabbadini Neves, Cláudia Farias Benjamim, Manuella Lanzetti, Samuel Santos Valenca
Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion and nitric oxide in asthma are poorly understood. Thus, the aim of this study was to investigate the mechanisms underlying the superoxide anion/nitric oxide production and detoxification in a murine asthma model...
August 24, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28764781/effects-of-the-combined-extracts-of-herba-epimedii-and-fructus-ligustrilucidi-on-airway-remodeling-in-the-asthmatic-rats-with-the-treatment-of-budesonide
#20
Xiufeng Tang, Honglei Nian, Xiaoxi Li, Yan Yang, Xiujuan Wang, Liping Xu, Haotian Shi, Xinwei Yang, Renhui Liu
BACKGROUND: Asthma is characterized by chronic airway inflammation, leading to structura1 changes in the airway, collectively termed airway remodeling. Airway remodeling is thought to contribute to airway hyper responsiveness and irreversible airflow limitation. The combination of Herba Epimedii (HE) and Fructus Ligustri Lucidi (FLL) decoction and the systemic administration of glucocorticoids (GC) had a synergistic inhibitory action on airway inflammation in the asthmatic model rats...
August 1, 2017: BMC Complementary and Alternative Medicine
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