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https://www.readbyqxmd.com/read/28946962/high-temperatures-and-nephrology-the-climate-change-problem
#1
Alberto de Lorenzo, Fernando Liaño
It is well known that climate change greatly affects human health, even though there are few studies on renal outcomes. Heat waves have been found to increase cardiovascular and respiratory morbidity and mortality, as well as the risk of acute renal failure and hospitalisation due to renal diseases, with related mortality. Recurrent dehydration in people regularly exposed to high temperatures seems to be resulting in an unrecognised cause of proteinuric chronic kidney disease, the underlying pathophysiological mechanism of which is becoming better understood...
September 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28805480/current-evidence-on-the-use-of-anti-raas-agents-in-congenital-or-acquired-solitary-kidney
#2
Mariadelina Simeoni, Annarita Armeni, Chiara Summaria, Annamaria Cerantonio, Giorgio Fuiano
RATIONAL: The inhibition of renin-angiotensin-aldosterone system (RAAS) is a major strategy for slowing the progression of chronic kidney disease (CKD). The utility of anti-RAAS agents in patients with congenital or acquired solitary kidney is still controversial. OBJECTIVE: A systematic literature review was conducted. MAIN FINDINGS: The conclusions of the few available studies on the topic are homogeneously in agreement with a long-term reno-protective activity of anti-RAAS drugs in patients with solitary kidney, especially if patients are hypertensive or proteinuric...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28717937/clinical-presentation-and-outcomes-of-childhood-onset-membranous-lupus-nephritis
#3
Maria Pereira, Eyal Muscal, Karen Eldin, M John Hicks, Anna Carmela P Sagcal-Gironella, Marietta DeGuzman, Scott E Wenderfer
BACKGROUND: Best practices for managing childhood-onset membranous lupus nephritis (MLN) are not yet established. Most studies involve primarily or exclusively adult cohorts or pediatric cohorts with combinations of pure or mixed membranous and proliferative nephritis. METHODS: We performed a single-center cohort study of consecutively diagnosed children with pure MLN from 1990 and 2016. Patients received care in Houston, Texas, one of the most diverse metropolitan areas in North America...
July 17, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28711069/preterm-birth-and-its-impact-on-renal-health
#4
Valerie A Luyckx
Preterm birth occurs in approximately 10% of all births worldwide. Preterm infants have reduced nephron numbers at birth in proportion to gestational age, and are at increased risk of neonatal acute kidney injury as well as higher blood pressure, proteinuria, and chronic kidney disease later in life. Rapid catch-up growth in preterm infants, especially if resulting in obesity, is a risk factor for end-stage kidney disease among children with proteinuric renal disease. Preterm birth, however, is a risk factor not only for the infant because mothers who deliver preterm have an increased risk of having subsequent preterm deliveries as well as hypertension, cardiovascular disease, and renal disease later in life...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28652469/blood-pressure-and-visit-to-visit-blood-pressure-variability-among-individuals-with-primary-proteinuric-glomerulopathies
#5
Christine B Sethna, Kevin E C Meyers, Laura H Mariani, Kevin J Psoter, Crystal A Gadegbeku, Keisha L Gibson, Tarak Srivastava, Matthias Kretzler, Tammy M Brady
Hypertension and blood pressure variability (BPV; SD and average real variability) in primary proteinuric glomerulopathies are not well described. Data were from 433 participants in the NEPTUNE (Nephrotic Syndrome Study Network). Hypertensive BP status was defined as previous history of hypertension or BP ≥140/90 mm Hg for adults/≥95th percentile for children at baseline. BPV was measured in participants with ≥3 visits in the first year. Two-hundred ninety-six adults (43 years [interquartile range, 32-57...
August 2017: Hypertension
https://www.readbyqxmd.com/read/28405891/renalase-in-children-with-glomerular-kidney-diseases
#6
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Mizerska-Wasiak, Elżbieta Kuźma-Mroczkowska, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Urszula Demkow, Małgorzata Pańczyk-Tomaszewska
Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. This study seeks to determine the role of renalase in children with glomerular kidney diseases. We evaluated the serum renalase, arterial stiffness, intima-media thickness, blood pressure, and clinical and biochemical parameters in 78 children (11.9 ± 4.6 years of age) with glomerulopathies such as idiopathic nephrotic syndrome (40 cases), IgA nephropathy (12 cases), Henoch-Schönlein nephropathy (12 cases), and other glomerulopathies (14 cases)...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28204946/clinical-outcomes-in-children-with-henoch-sch%C3%A3-nlein-purpura-nephritis-without-crescents
#7
Jean Daniel Delbet, Julien Hogan, Bilal Aoun, Iulia Stoica, Rémi Salomon, Stéphane Decramer, Isabelle Brocheriou, Georges Deschênes, Tim Ulinski
BACKGROUND: Henoch-Schönlein purpura is the most common vasculitis in children. Its long-term prognosis depends on renal involvement. The management of Henoch-Schönlein purpura nephritis (HSPN) remains controversial. This study reports the prognosis of children with HSPN presenting with class 2 International Study of Kidney Disease in Children (ISKDC) nephritis. METHODS: All children with HSPN class 2 diagnosed between 1995 and 2015 in four pediatric nephrology centers were included, and clinical and biological data were collected from the medical files...
July 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27704256/achieving-remission-of-proteinuria-in-childhood-ckd
#8
Piero Ruggenenti, Paolo Cravedi, Antonietta Chianca, MariaRosa Caruso, Giuseppe Remuzzi
BACKGROUND: A multidrug treatment strategy that targets urinary proteins with an angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) up-titrated to the respective maximum tolerated dose combined with intensified blood pressure (BP) control has been found to prevent renal function loss in adults with proteinuric nephropathies. Herein, we investigated the effects of this treatment protocol in the pediatric patient population. METHODS: From May 2002 to September 2014 we included in this observational, longitudinal, cohort study 20 consecutive children with chronic nephropathies and 24-h proteinuria of >200 mg who had received ramipril and losartan up-titrated to the respective maximum approved and tolerated doses [mean (standard deviation) dose:2...
February 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27508764/-op-6a-01-renalase-in-children-with-glomerular-kidney-diseases
#9
P Skrzypczyk, M Panczyk-Tomaszewska, J Przychodzien, M Mizerska-Wasiak, E Kuzma-Mroczkowska, E Gorska, A Stelmaszczyk-Emmel
OBJECTIVE: Renalase is a protein produced mainly by kidneys. Renalase inactivates circulating catecholamines catalyzing process of their oxidation. Studies in adults with kidney disease suggest that renalase may play a role in pathogenesis of hypertension and target organ damage. The aim of the study was to assess level of renalase in children with glomerular kidney diseases and to find the relation between renalase level and clinical parameters in this group of patients. DESIGN AND METHOD: In 78 children (47 M, 31F) aged from 3...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27285824/morphometry-predicts-early-gfr-change-in-primary-proteinuric-glomerulopathies-a-longitudinal-cohort-study-using-generalized-estimating-equations
#10
MULTICENTER STUDY
Kevin V Lemley, Serena M Bagnasco, Cynthia C Nast, Laura Barisoni, Catherine M Conway, Stephen M Hewitt, Peter X K Song
OBJECTIVE: Most predictive models of kidney disease progression have not incorporated structural data. If structural variables have been used in models, they have generally been only semi-quantitative. METHODS: We examined the predictive utility of quantitative structural parameters measured on the digital images of baseline kidney biopsies from the NEPTUNE study of primary proteinuric glomerulopathies. These variables were included in longitudinal statistical models predicting the change in estimated glomerular filtration rate (eGFR) over up to 55 months of follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27070416/circulating-supar-as-a-biomarker-of-disease-severity-in-children-with-proteinuric-glomerulonephritis
#11
Soltysiak Jolanta, Zachwieja Jacek, Benedyk Anna, Lewandowska-Stachowiak Maria, Nowicki Michal, Ostalska-Nowicka Danuta
BACKGROUND: The increase of circulating urokinase plasminogen activator receptor (suPAR) was demonstrated in various diseases showing its prognostic value as well as the link to the inflammatory reaction. In glomerular diseases suPAR was consider to be a causative factor of proteinuria. In present study we aimed to evaluate serum concentration of suPAR in children with primary and secondary glomerulonephritis (GN) and its association with disease severity. METHODS: The study involved 22 children with minimal change disease (MCD), 9 with primary focal segmental glomerulosclerosis (FSGS), 7 with Henoch-Schönlein nephritis (HSN), 7 with lupus nephritis (LN) and 16 controls...
April 12, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/26656320/complete-remission-in-the-nephrotic-syndrome-study-network
#12
MULTICENTER STUDY
Debbie S Gipson, Jonathan P Troost, Richard A Lafayette, Michelle A Hladunewich, Howard Trachtman, Crystal A Gadegbeku, John R Sedor, Lawrence B Holzman, Marva M Moxey-Mims, Kalyani Perumal, Frederick J Kaskel, Peter J Nelson, Katherine R Tuttle, Serena M Bagnasco, Marie C Hogan, Katherine M Dell, Gerald B Appel, John C Lieske, Titilayo O Ilori, Christine B Sethna, Fernando C Fervenza, Susan L Hogan, Patrick H Nachman, Avi Z Rosenberg, Larry A Greenbaum, Kevin E C Meyers, Stephen M Hewitt, Michael J Choi, Jeffrey B Kopp, Olga Zhdanova, Jeffrey B Hodgin, Duncan B Johnstone, Sharon G Adler, Carmen Avila-Casado, Alicia M Neu, Sangeeta R Hingorani, Kevin V Lemley, Cynthia C Nast, Tammy M Brady, Laura Barisoni-Thomas, Alessia Fornoni, J Charles Jennette, Daniel C Cattran, Matthew B Palmer, Keisha L Gibson, Heather N Reich, Michele H Mokrzycki, Kamalanathan K Sambandam, Gaston E Zilleruelo, Christoph Licht, Matthew G Sampson, Peter Song, Laura H Mariani, Matthias Kretzler
BACKGROUND AND OBJECTIVES: This analysis from the Nephrotic Syndrome Study Network (NEPTUNE) assessed the phenotypic and pathology characteristics of proteinuric patients undergoing kidney biopsy and defined the frequency and factors associated with complete proteinuria remission (CRever). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We enrolled adults and children with proteinuria ≥0.5 g/d at the time of first clinically indicated renal biopsy at 21 sites in North America from April 2010 to June 2014 into a prospective cohort study...
January 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26551740/regulation-of-trpc6-ion-channels-in-podocytes-implications-for-focal-segmental-glomerulosclerosis-and-acquired-forms-of-proteinuric-diseases
#13
REVIEW
T Szabó, L Ambrus, N Zákány, Gy Balla, T Bíró
The glomerular filtration barrier is a highly specialized tri-layer structure with unique functional properties. Podocyte dysfunction and cytoskeletal disorganization leads to disruption of the slit diaphragma, and proteinuria. Inflammatory diseases involving the kidney as well as inherited podocytopathies or diabetic nephropathy cause injury of the podocyte network. Focal segmental glomerulosclerosis (FSGS) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children...
September 2015: Acta Physiologica Hungarica
https://www.readbyqxmd.com/read/26135137/clinical-efficacy-and-pharmacokinetics-of-tacrolimus-in-children-with-steroid-resistant-nephrotic-syndrome
#14
Afsana Jahan, Ratna Prabha, Swasti Chaturvedi, Binu Mathew, Denise Fleming, Indira Agarwal
BACKGROUND: Tacrolimus has gained acceptance in the management of steroid-resistant nephrotic syndrome (SRNS) in children. Due to limited data, therapeutic range is extrapolated from pediatric renal transplant recipients. This study was designed to assess therapeutic efficacy of tacrolimus in children with SRNS and its correlation with inter-dose area under concentration curve (AUC0-12 h) and trough concentration (C0). METHODS: Pre dose, 0.5, 1.0, 1.5, 2.0, 2.5, 3, 4, 8, and 12 h after drug administration blood samples were collected in 25 children who were on tacrolimus for a minimum of 3 months and AUC0-12 h was calculated...
November 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26102431/monitoring-of-mycophenolate-mofetil-metabolites-in-children-with-nephrotic-syndrome-and-the-proposed-novel-target-values-of-pharmacokinetic-parameters
#15
Joanna Sobiak, Matylda Resztak, Danuta Ostalska-Nowicka, Jacek Zachwieja, Karolina Gąsiorowska, Wiktoria Piechanowska, Maria Chrzanowska
The aim of the study was to estimate target values of mycophenolate mofetil (MMF) pharmacokinetic parameters in children with proteinuric glomerulopathies by calculating the pharmacokinetic parameters of MMF metabolites (mycophenolic acid [MPA], free MPA [fMPA] and MPA glucuronide [MPAG]) and assessing their relation to proteinuria recurrence. One hundred and sixty-eight blood samples were collected from children, aged 3-18 years, diagnosed with nephrotic syndrome or lupus nephritis. MMF metabolites concentrations were examined before drug administration (Ctrough) and up to 12h afterward employing high-performance liquid chromatography...
September 18, 2015: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25925040/proteinuria-1-year-after-renal-transplantation-is-associated-with-impaired-graft-survival-in-children
#16
Tomáš Rosík, Mária Chadimová, Jiří Dušek, Jaromír Háček, Naděžda Šimánková, Karel Vondrák, Jakub Zieg, Tomáš Seeman
BACKGROUND: Proteinuria is a common manifestation of chronic kidney disease (CKD), and there is a high incidence of CDK and its complications following renal transplantation. However, little data are available on the association between proteinuria and graft/patient survival in the paediatric transplant population. The primary aim of this study was to investigate the associations between posttransplant proteinuria and graft/patient survival in children after renal transplantation. METHODS: In this retrospective study, we screened all 91 children receiving renal allografts at a single institution between 1997 and 2007...
October 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/25922138/the-utility-of-bioimpedance-analysis-for-monitoring-the-children-with-nutcracker-syndrome
#17
Sevgi Yavuz, Aysel Kıyak, Ali Er, Orhan Korkmaz
UNLABELLED: We aimed to evaluate anthropometric and bioimpedance analysis (BIA) indices of children with nutcracker syndrome (NCS). Eighteen patients and 20 age-gender matched controls were enrolled. Weight, height, body mass index (BMI), mid-arm circumference (MAC), waist circumference (WC), waist/hip ratio measurements, and BIA results were assessed. Laboratory parameters and Doppler sonographic findings were recorded. The weight, BMI, MAC, WC, body fat z scores, and waist/hip ratio were significantly lower in patients than in controls (p < 0...
October 2015: European Journal of Pediatrics
https://www.readbyqxmd.com/read/25790939/inhibition-of-rho-associated-kinase-relieves-c5a-induced-proteinuria-in-murine-nephrotic-syndrome
#18
I-Jung Tsai, Chia-Hung Chou, Yao-Hsu Yang, Wei-Chou Lin, Yen-Hung Lin, Lu-Ping Chow, Hsiao-Hui Lee, Pei-Gang Kao, Wan-Ting Liau, Tzuu-Shuh Jou, Yong-Kwei Tsau
Childhood nephrotic syndrome is mainly caused by minimal change disease which is named because only subtle ultrastructural alteration could be observed at electron microscopic level in the pathological kidney. Glomerular podocytes are presumed to be the target cells whose protein sieving capability is compromised by a yet unidentified permeability perturbing factor. In a cohort of children with non-hereditary idiopathic nephrotic syndrome, we found the complement fragment C5a was elevated in their sera during active disease...
August 2015: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/25754750/mizoribine-in-the-treatment-of-pediatric-onset-glomerular-disease
#19
REVIEW
Hiroshi Tanaka, Kazushi Tsuruga, Taddatsu Imaizumi
BACKGROUND: Mizoribine (MZR) is a selective inhibitor of inosine monophosphate dehydrogenase, a key enzyme in the pathway responsible for de novo synthesis of guanine nucleotides. As an immunosuppressant, MZR has been used successfully without any serious adverse effects in the treatment of renal diseases in children as well as adults. Besides its immunosuppressive effect, MZR has been reported to ameliorate tubulointerstitial fibrosis in rats via suppression of macrophage infiltration...
May 2015: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/25615955/simple-markers-for-subclinical-inflammation-in-patients-with-familial-mediterranean-fever
#20
Samet Özer, Resul Yılmaz, Ergün Sönmezgöz, Erhan Karaaslan, Semanur Taşkın, İlknur Bütün, Osman Demir
BACKGROUND: In this study we investigated the potential of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell width distribution (RDW) as new inflammatory markers to identify chronic inflammations during symptom-free periods in children diagnosed with Familial Mediterranean Fever (FMF). MATERIAL/METHODS: The study included 153 children diagnosed with FMF based on the Tel-Hashomer Criteria, and 90 healthy volunteers...
January 23, 2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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