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Gamma GT

Jang Yoo, Bom Sahn Kim, Hai-Jeon Yoon
OBJECTIVE: We evaluated the significance of breast-specific gamma imaging (BSGI) for determination of upstaging to invasive cancer from preoperative ductal carcinoma in situ (DCIS). METHODS: This study enrolled 168 patients with 175 breast lesions diagnosed as DCIS on core-needle biopsy that subsequently underwent preoperative BSGI between September 2011 and October 2017. Both qualitative and quantitative analyses using tumor-to-normal background ratio (TNR) and coefficient of variation (COV) were performed, and the predictive significance for upstaging to invasive cancer was investigated...
March 19, 2018: Annals of Nuclear Medicine
João Castelhano, Paula Tavares, Susana Mouga, Guiomar Oliveira, Miguel Castelo-Branco
OBJECTIVE: Electroencephalographic biomarkers have been widely investigated in autism, in the search for diagnostic, prognostic and therapeutic outcome measures. Here we took advantage of the information available in temporal oscillatory patterns evoked by simple perceptual decisions to investigate whether stimulus dependent oscillatory signatures can be used as potential biomarkers in autism spectrum disorder (ASD). METHODS: We studied an extensive set of stimuli (9 categories of faces) and performed data driven classification (Support vector machine, SVM) of ASD vs...
February 20, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Anne Zaparucha
Amino alcohols are versatile compounds with a wide range of applications. For instance, they have been used as chiral scaffolds in organic synthesis. Their synthesis by conventional organic chemistry often requires tedious multi-step synthesis processes, with difficult control of the stereochemical outcome. We present a protocol to enzymatically synthetize amino alcohols starting from the readily available L-lysine in 48 h. This protocol combines two chemical reactions that are very difficult to conduct by conventional organic synthesis...
February 16, 2018: Journal of Visualized Experiments: JoVE
Isaac Winkler, Sonja J Scheffer, Matthew L Lewis, Kristina J Ottens, Andrew P Rasmussen, Géssica A Gomes-Costa, Luz Maria Huerto Santillan, Marty A Condon, Andrew A Forbes
BACKGROUND: Much evolutionary theory predicts that diversity arises via both adaptive radiation (diversification driven by selection against niche-overlap within communities) and divergence of geographically isolated populations. We focus on tropical fruit flies (Blepharoneura, Tephritidae) that reveal unexpected patterns of niche-overlap within local communities. Throughout the Neotropics, multiple sympatric non-interbreeding populations often share the same highly specialized patterns of host use (e...
March 14, 2018: BMC Evolutionary Biology
Youngbeom Seo, Dong Gyu Kim, Yun-Sik Dho, Jin Wook Kim, Yong Hwy Kim, Chul-Kee Park, Hyun-Tai Chung, Sun-Ha Paek
BACKGROUND: Gamma knife radiosurgery (GKRS) has recently been used as a treatment modality for dural arteriovenous fistula (DAVF). OBJECTIVE: To retrospectively analyze the outcomes of GKRS for DAVF at a single institute. METHODS: Between 1998 and 2016, a total of 20 patients underwent GKRS for DAVF. After excluding 4 patients with > 12 months of follow-up, 16 patients were enrolled in this study. Twelve patients had undergone embolization prior to GKRS...
March 14, 2018: Stereotactic and Functional Neurosurgery
Nina Wolinski, Nicholas R Cooper, Paul Sauseng, Vincenzo Romei
The speed of theta brain oscillatory activity is thought to play a key role in determining working memory (WM) capacity. Individual differences in the length of a theta cycle (ranging between 4 and 7 Hz) might determine how many gamma cycles (>30 Hz) can be nested into a theta wave. Gamma cycles are thought to represent single memory items; therefore, this interplay could determine individual memory capacity. We directly tested this hypothesis by means of parietal transcranial alternating current stimulation (tACS) set at slower (4 Hz) and faster (7 Hz) theta frequencies during a visuospatial WM paradigm...
March 14, 2018: PLoS Biology
Yi-Yi Wang, Bing-di Xie
Central nervous system (CNS) disease caused by Mycobacterium tuberculosis (MTB) is highly devastating. Tuberculous meningitis (TBM) is the most common form of CNS tuberculosis (TB). Rapid, sensitive, and affordable diagnostic tests are not available. Ziehl-Neelsen (ZN) stain has a very low sensitivity in cases of TBM, the sensitivity rates is of about 10-20%.The detection rate can be improved by taking large volume CSF samples (>6 ml) and prolonged slide examination (30 min). Culture of MTB from the CSF is slow and insufficiently sensitive...
2018: Methods in Molecular Biology
Eda Balkan, Handan Bilen, Nilnur Eyerci, Sadullah Keleş, Aslı Kara, Necmettin Akdeniz, Hasan Dogan
BACKGROUND To investigate the gene expression levels of interleukin 10 (IL10), IL18, interferon gamma (IFNG), IFN-gamma receptor (IFNGR), C-reactive protein (CRP), and heat shock protein 70 (HSP70) in patients with active Behçet's uveitis. MATERIAL AND METHODS Forty patients with Behçet's disease diagnosed according to the International Study Group criteria and 30 healthy individuals were included in the study. IL10, IL18, IFNG, IFNGR, CRP, and HSP70 gene expression levels were compared. RESULTS Expression levels of IL18, IFNG, IFNGR, and CRP were significantly higher in patients with active Behçet's uveitis than in control subjects (P<0...
March 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ronald Sahyouni, Hossein Mahboubi, Omid Moshtaghi, Khodayar Goshtasbi, Sammy Sahyouni, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: 1) Perform a meta-analysis of the available data on the outcomes of stereotactic radiosurgery (SRS) for the treatment of temporal bone glomus tumors (GT), and 2) evaluate the collective outcomes of SRS treatment with respect to tumor control. DATA SOURCES: A thorough literature search of the published English-language literature from 2011 to 2016 was performed in PubMed, Ovid, and Cochrane databases using the keywords ("Gamma Knife" or "CyberKnife" or "linear accelerator" or "radiosurgery") and ("glomus jugulare" or "jugular paraganglioma" or "glomus tympanicum")...
April 2018: Otology & Neurotology
Silvia Perés Wingeyer, Federico Aranda, Sebastián Udry, José Latino, Gabriela de Larrañaga
BACKGROUND AND OBJECTIVES: Thrombophilia might increase the risk of suffering from obstetric complications by adversely affecting the normal placental vascular function. Our aim was to study the distributions of five thrombosis-associated genetic variants: factor V Leiden, prothrombin G20210A, -675 4G/5G PAI-1, 10034C/T gamma fibrinogen and 7872C/T factor XI and the frequencies of the deficiencies of protein C, S and antithrombin in Argentinian patients with recurrent pregnancy loss (RPL) and, therefore, to analyse their association with the risk and timing of RPL and the risk of suffering other vascular obstetric pathologies...
March 6, 2018: Medicina Clínica
R D X Ribeiro, G G P Carvalho, T M Silva, J B Costa, L R Bezerra, G B Cambuí, A M Barbosa, R L Oliveira
This study was conducted to test the hypothesis that the inclusion of crude glycerin of up to 21% of dry matter (DM) in the diets of lambs will not compromise variables related to animal production or health. Forty-four uncastrated Santa Inês crossbreed lambs with an average age of five months and a BW average of 23.9 ± 0.34 kg (mean ± SD) were distributed into four treatment groups (11 replicates per group) including 0%, 7%, 14%, or 21% crude glycerin on a DM basis. The inclusion of crude glycerin in the diets promoted a quadratic increase in DM (P = 0...
March 6, 2018: Journal of Animal Science
Jie Li, Guohai Qi, Yuan Qin, Pei Wang
Objective: The objective of this study is to preliminarily evaluate the feasibility of brass compensator-based intensity-modulated radiation therapy (CB-IMRT). Materials and Methods: Ten patients (three cases of nasopharyngeal cancer, four of esophageal cancer, and three of rectal cancer) who underwent an IMRT treatment planning were selected for this study. The transmission coefficient of brass plates with different thicknesses was measured under a 6 MV photon beam used in the treatment planning system, and the equation for thickness computation was fitted out...
January 2018: Journal of Cancer Research and Therapeutics
Jyrki K Virtanen, Jaakko Mursu, Sari Voutilainen, Tomi-Pekka Tuomainen
BACKGROUND/OBJECTIVES: There are concerns that high intake of n-6 polyunsaturated fatty acids (PUFA) may promote inflammation, because the end-product of n-6 PUFA metabolism, arachidonic acid, is a precursor for pro-inflammatory eicosanoids. Our aim was to investigate cross-sectional associations of the serum n-6 PUFAs, objective biomarkers for exposure, with serum high-sensitivity C-reactive protein (CRP), a key inflammation marker. SUBJECTS/METHODS: The study included 1287 generally healthy men aged 42-60 years from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study, examined in 1984-1989...
March 2018: European Journal of Clinical Nutrition
Liliana Stolarczyk, Sebastian Trinkl, Maite Romero-Exposito, Natalia Mojżeszek, Iva Ambrozova, Carles Domingo, Marie Davidkova, Jad Farah, Magdalena Kłodowska, Željka Knežević, Małgorzata Liszka, Marija Majer, Saveta Miljanic, Ondrej Ploc, Marco Schwarz, Roger Michael Harrison, Pawel Olko
Systematic 3-D mapping of out-of-field doses induced by a therapeutic proton pencil scanning beam (PBS) in a 300 × 300 × 600 mm3 water phantom was performed using a set of thermoluminescence detectors (TLD): MTS-7 (&lt;sup&gt;7&lt;/sup&gt;LiF:Mg,Ti), MTS-6 (&lt;sup&gt;6&lt;/sup&gt;LiF:Mg,Ti), MTS-N (&lt;sup&gt;nat&lt;/sup&gt;LiF:Mg,Ti) and TLD-700 (&lt;sup&gt;7&lt;/sup&gt;LiF:Mg,Ti), radiophotoluminescent detectors (RPL) GD-352M and GD-302M and polyallyldiglycol carbonate (PADC)-based (C&lt;sub&gt;12&lt;/sub&gt;H&lt;sub&gt;18&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt;) track-etched detectors...
March 6, 2018: Physics in Medicine and Biology
Fabian Speth, Claas H Hinze, Susanne Andel, Thomas Mertens, Johannes-Peter Haas
BACKGROUND: The goal of this study was to apply the varicella zoster virus (VZV) vaccine to patients with pediatric rheumatic diseases (PRD) at risk for severe chickenpox, without interrupting their current immunosuppression, including biological agents, using an immunological-based pre-vaccination checklist to assure safety. A pre-vaccination checklist was implemented to ensure adequate immune competence prior to immunization. METHODS: This prospective study included seronegative patients (VZV-IgG ≤200 mIU/ml) and patients who had previously received only a single dose of VZV vaccine...
March 2, 2018: Pediatric Rheumatology Online Journal
Mary Adjepong, C Austin Pickens, Raghav Jain, William S Harris, Reginald A Annan, Jenifer I Fenton
In Northern Ghana, 33% of children are stunted due to economic disparities. Dietary fatty acids (FA) are critical for growth, but whether blood FA levels are adequate in Ghanaian children is unknown. The objective of this study was to determine the association between whole blood FAs and growth parameters in Northern Ghanaian children 2-6 years of age. A drop of blood was collected on an antioxidant treated card and analyzed for FA composition. Weight and height were measured and z-scores were calculated. Relationships between FAs and growth parameters were analyzed by Spearman correlations, linear regressions, and factor analysis...
2018: PloS One
Yan Zheng, Yu-Qing Rao, Jia-Kai Li, Yue Huang, Peiquan Zhao, Jing Li
AIM: To reveal age-related aqueous cytokine changes in human aqueous humor. METHODS: Aqueous humor was collected from 12 young children (3-6.5 years old) and 71 healthy adults (22-106 years old) with cataract but without other systemic or ocular disorders. Levels of 22 cytokines, chemokines and vascular endothelial growth factor (VEGF) were measured and analyzed. RESULTS: The following proteins showed significant increase from childhood to adult: interferon-gamma (IFN-γ), interleukin (IL)-13, IL-6, IL-12(p70), IL-10, CCL2, CCL3, CCL4, CXCL8, CXCL9, CXCL10, IFN-α2 and VEGF (all P <0...
2018: International Journal of Ophthalmology
M L Arnold, A Kainz, L G Hidalgo, F Eskandary, N Kozakowski, M Wahrmann, H Haslacher, R Oberbauer, A Heilos, B M Spriewald, P F Halloran, G A Böhmig
Fc-dependent effector mechanisms may contribute to antibody-mediated rejection (ABMR), and distinct gene polymorphisms modifying the function of Fc gamma receptors (FcγR) may potentially influence the capability of donor-specific antibodies (DSA) to trigger inflammation. To evaluate the relevance of functional FcγR variants in late ABMR, 85 DSA-positive kidney allograft recipients, who were recruited upon antibody screening of 741 prevalent patients, were genotyped for polymorphisms in FcγRIIA (FCGR2A-H/R131 ; rs1801274), FcγRIIIA (FCGR3A-V/F158 ; rs396991) and FcγRIIIB [FCGR3B-neutrophil antigen 1 (NA1)/NA2; rs35139848]...
February 25, 2018: American Journal of Transplantation
Hani Oweira, Imad Lahdou, Volker Daniel, Jan Schmidt, Arianeb Mehrabi, Mahmoud Sadeghi
BACKGROUND We evaluated whether effluent parameters prior to reperfusion correlate with post-transplant outcomes in liver transplant recipients. MATERIAL AND METHODS Concentrations of high mobility group box 1 protein (HMGB1), uncleaved cytokeratin-18 (M65), caspase-cleaved cytokeratin 18 fragment (M30), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP) were measured in effluent samples from 53 adult liver recipients (42 survived for 1 year and 11 did not survive)...
February 23, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
J R Crawford, A K H Robertson, H Yang, C Rodríguez-Rodríguez, P L Esquinas, P Kunz, S Blinder, V Sossi, P Schaffer, T J Ruth
The development of alpha-emitting radiopharmaceuticals using211 At requires quantitative determination of the time-dependent nature of the211 At biodistribution. However, imaging-based methods for acquiring this information with211 At have not found wide-spread use because of its low abundance of decay emissions suitable for external detection. In this publication we demonstrate the theranostic abilities of the211 At/209 At isotope pair and present the first-ever209 At SPECT images. The VECTor microSPECT/PET/CT scanner was used to image209 At with a collimator suitable for the 511 keV annihilation photons of PET isotopes...
February 21, 2018: Physics in Medicine and Biology
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