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https://www.readbyqxmd.com/read/29333610/clinical-features-and-treatment-of-nonalcoholic-fatty-liver-disease-across-the-asia-pacific-region-the-go-asia-initiative
#1
W-K Chan, S Treeprasertsuk, K Imajo, A Nakajima, Y Seki, K Kasama, S Kakizaki, J-G Fan, M J Song, S K Yoon, Y-Y Dan, L Lesmana, K-Y Ho, K-L Goh, V W-S Wong
BACKGROUND: The Gut and Obesity Asia (GO ASIA) workgroup was formed to study the relationships between obesity and gastrointestinal diseases in the Asia Pacific region. AIM: To study factors associated with nonalcoholic steatohepatitis (NASH) and advanced fibrosis, and medical treatment of biopsy-proven nonalcoholic fatty liver disease (NAFLD) patients. METHODS: Retrospective study of biopsy-proven NAFLD patients from centres in the GO ASIA Workgroup...
January 14, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29332607/the-role-of-t2-weighted-gradient-echo-in-the-diagnosis-of-tumefactive-intrahepatic-extramedullary-hematopoiesis-in-myelodysplastic-syndrome-and-diffuse-hepatic-iron-overload-a-case-report-and-review-of-the-literature
#2
Abel A Belay, Andrew M Bellizzi, Alan H Stolpen
BACKGROUND: Extramedullary hematopoiesis is the proliferation of hematopoietic cells outside bone marrow secondary to marrow hematopoiesis failure. Extramedullary hematopoiesis rarely presents as a mass-forming hepatic lesion; in this case, imaging-based differentiation from primary and metastatic hepatic neoplasms is difficult, often leading to biopsy for definitive diagnosis. We report a case of tumefactive hepatic extramedullary hematopoiesis in the setting of myelodysplastic syndrome with concurrent hepatic iron overload, and the role of T2*-weighted gradient-echo magnetic resonance imaging in differentiating extramedullary hematopoiesis from primary and metastatic hepatic lesions...
January 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29325281/-value-of-hydrogen-proton-magnetic-resonance-spectroscopy-in-the-determination-of-liver-triglyceride-in-patients-with-fatty-liver-disease-and-its-influencing-factors
#3
H J Qu, L Wang, P H Jin, Q Gao, J X Zhou, Y Song, J Wang, Y M Jiang, L Gong, G Y Chen, J P Ding, J P Shi
Objective: To investigate the value of 1H-magnetic resonance spectroscopy ((1)H-MRS) in determining the content of liver triglyceride in patients with fatty liver disease (FLD), as well as its influencing factors. Methods: A total of 124 patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis B (CHB), or hepatitis B complicated by FLD who underwent liver biopsy in the Affiliated Hospital of Hangzhou Normal University were enrolled, and the clinical data, serological markers, FibroScan results, and (1)H-MRS results were collected...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29285861/biliary-versus-thyroid-like-a-tale-of-two-morphologies
#4
Sharon J Song, Kathleen Montone, Kristen Stashek, Rashmi Tondon
Pictured here is a portacaval lymph node biopsy from a 72-year-old man with an 11.9 cm liver mass and several enlarged surrounding lymph nodes. The node was involved by a tumor with two distinct morphologies-one area resembling a primary pancreaticobiliary tumor (Figure 1) and another mimicking a thyroid follicular carcinoma with microfollicles containing brightly eosinophilic, colloid-like secretions (Figure 2). Immunohistochemistry showed the neoplastic cells to stain strongly with CK7 and CK19, with patchy positivity for CK20...
December 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29285688/pancreatoblastoma-an-unusual-diagnosis-in-an-adult-patient
#5
Gonçalo Nunes, Hélder Coelho, Marta Patita, Rita Barosa, Pedro Pinto Marques, Lídia Roque Ramos, Maria José Brito, Aurora Tomaz, Jorge Fonseca
The authors describe a 31-year-old man admitted due to progressive weight loss, diarrhea and massive hepatomegaly. Laboratory data showed anemia (haemoglobin 11.7 g/dl), abnormal liver tests (total bilirubin 1.4 g/dl, aspartate aminotransferase 70 U/l, alanine aminotransferase 37 U/l and alkaline phosphatase 520 U/l). Abdominal ultrasound (US) displayed a large heterogeneous liver with a segment IV 25 mm nodule. Magnetic resonance revealed a 4 cm pancreatic tail mass and several liver nodules consistent with metastasis...
December 28, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29285064/predictors-for-advanced-liver-fibrosis-in-chronic-hepatitis-b-virus-infection-with-persistently-normal-or-mildly-elevated-alanine-aminotransferase
#6
Dexin Wang, Ping Zhang, Min Zhang
The aim of the present study was to evaluate the predictors for advanced liver fibrosis in patients with chronic hepatitis B virus (HBV) infection with persistently normal alanine aminotransferase (PNALT), or persistently or intermittently mildly elevated ALT (PIEALT). A total of 305 patients were included in the present study. Liver biopsies were evaluated using the METAVIR scoring system. Liver stiffness (LS) was measured using Fibroscan. Multivariate logistic regression and the area under the receiver operating characteristic curve (AUROC) were used to examine the diagnostic value of the predictors for advanced liver fibrosis...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29281781/erdheim-chester-disease-involving-lymph-nodes-and-liver-clinically-mimicking-lymphoma-a-case-report
#7
Yeoun Eun Sung, Yoon Seo Lee, Jieun Lee, Kyo Young Lee
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis and multisystem disease. First described in 1930, there are no more than 750 cases reported. The etiology remains unknown, but a majority of cases of ECD and Langerhans cell histiocytosis were found to have clonal mutations involving genes of the MAPK pathway. We recently encountered a 53-year-old male patient with extensive ECD involving the systemic lymph nodes, pleura, liver, and long bones clinically mimicking malignant lymphoma. Biopsies were performed at multiple sites, including a pleural mass, an external iliac lymph node, bone marrow, and the liver...
December 27, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29279503/lung-metastases-from-bile-duct-adenocarcinoma-mimicking-chronic-airway-infection-and-causing-diagnostic-difficulty
#8
Mitsuo Sato, Shotaro Okachi, Jun Fukihara, Yoshie Shimoyama, Keiko Wakahara, Toshihiro Sakakibara, Tetsunari Hase, Yasuharu Onishi, Yasuhiro Ogura, Osamu Maeda, Yoshinori Hasegawa
We herein report a case of lung metastases with unusual radiological appearances that mimicked those of chronic airway infection, causing diagnostic difficulty. A 60-year-old woman who underwent liver transplantation from a living donor was incidentally diagnosed with bile duct adenocarcinoma after a histopathological analysis of her explanted liver. Six months later, chest computed tomography (CT) revealed bilateral bronchogenic dissemination that had gradually worsened, suggesting chronic airway infection...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29249532/omega-3-pufa-modulate-lipogenesis-er-stress-and-mitochondrial-dysfunction-markers-in-nash-proteomic-and-lipidomic-insight
#9
Lívia Samara Dos Reis Rodrigues Okada, Claudia P Oliveira, José Tadeu Stefano, Monize Aydar Nogueira, Ismael Dale Cotrim Guerreiro da Silva, Fernanda Bertucce Cordeiro, Venâncio Avancini Ferreira Alves, Raquel Susana Torrinhas, Flair José Carrilho, Puneet Puri, Dan L Waitzberg
BACKGROUND & AIMS: Currently there is no FDA-approved therapy for nonalcoholic steatohepatitis (NASH). Increased n-6/n-3 polyunsaturated fatty acids (PUFA) ratio can induce endoplasmic reticulum (ER) stress and mitochondrial dysfunction that characterize NASH. Our recent study with n-3 PUFA showed improvement in individual histologic parameters like steatosis, ballooning and lobular inflammation. We hypothesized that n-3 PUFA therapy mediated improvement in histologic parameters is modulated by lipidomic and proteomic changes...
September 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29245304/computed-tomography-imaging-features-of-hepatic-perivascular-epithelioid-cell-tumor-a-case-report-and-literature-review
#10
Xu Han, Mei-Yu Sun, Jing-Hong Liu, Xiao-Yan Zhang, Meng-Yao Wang, Rui Fan, Sahrish Qamar
RATIONALE: Perivascular epithelioid cell tumor (PEComa) is a rare tumor which is most frequently found in uterus. The tumor arising from liver is extremely uncommon. PATIENT CONCERNS: A 36-year-old female with abdominal distention, cramps, and low-grade fever for over 15 days. The patient had a history of gastric adenocarcinoma with ovarian, celiac lymph nodes, and retroperitoneal lymph nodes metastases. DIAGNOSES: Computed tomography (CT) imaging demonstrated an ill-defined heterogeneous hypo-dense mass in segment 8 (S8) of the liver...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245282/gastroenteropancreatic-origin-neuroendocrine-carcinomas-three-case-reports-with-favorable-responses-following-localized-radiotherapy-and-a-review-of-literature
#11
Yong Gyun Won, Kyung-Jin Seo, Jiyeon Hyeon, Ok Ran Shin, Eundeok Chang, Der Sheng Sun, Hae Sung Won, Yoon Ho Ko, Sae Jung Na, Su Lim Lee, Young Mi Ku, Dong Soo Lee
RATIONALE: The radiotherapy (RT) responses of gastroenteropancreatic (GEP)-origin neuroendocrine tumors remain unclear. We report cases of favorable response after localized RT of GEP-origin neuroendocrine carcinomas (GEP-NECs). PATIENT CONCERNS: 1. An 82-year-old male presented with a lower esophageal mass. Positron emission tomography computed tomography (PET-CT) scan showed a lower esophageal mass and gastrohepatic lymph nodes. 2. A 52-year-old female presented with abdominal discomfort...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29230298/hepatic-paragonimiasis-a-single-center-retrospective-analysis-of-32-cases-in-mainland-china
#12
Xiwen Ye, Xianze Xiong, Nansheng Cheng, Jiong Lu, Yixin Lin
Background: In paragonimiasis, the lungs and pleural cavity are the major target organs, and the central nervous system can also be affected. The liver is an organ in which ectopic paragonimiasis rarely occurs. Because the symptoms and examinations in hepatic paragonimiasis (HP) are not typical, the disease is often misdiagnosed in the clinic. Methods: From February 2008 to March 2015, our department accepted 32 patients who presented with a liver mass upon ultrasound and computed tomography imaging and in whom the source of the mass could not be identified upon numerous further diagnostic tests...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29218663/laparoscopic-extended-cholecystectomy-for-t3-gallbladder-cancer
#13
Sungho Kim, Yoo-Seok Yoon, Ho-Seong Han, Jai Young Cho, YoungRok Choi
BACKGROUND: Gallbladder cancer (GBC) has been contraindicated for laparoscopic surgery since this procedure was introduced [1, 2]. Recently, however, there have been several reports of laparoscopic extended cholecystectomy for GBC, but most cases involved early GBC confined to the GB [3, 4]. This video describes our technique of laparoscopic extended cholecystectomy for T3 GBC. METHODS: A 77-year-old female presented with a gallbladder mass, which was incidentally detected during evaluation of back pain...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218660/how-bariatric-surgery-affects-liver-volume-and-fat-density-in-nafld-patients
#14
Ran B Luo, Toshiaki Suzuki, Jonathan C Hooker, Yesenia Covarrubias, Alexandra Schlein, Shanglei Liu, Jeffrey B Schwimmer, Scott B Reeder, Luke M Funk, Jacob A Greenberg, Guilherme M Campos, Bryan J Sandler, Santiago Horgan, Claude B Sirlin, Garth R Jacobsen
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is an epidemic in the obese population. Bariatric surgery is known to reverse multiple metabolic complications of obesity such as diabetes, dyslipidemia, and NAFLD, but the timing of liver changes has not been well described. MATERIALS AND METHODS: This was an IRB-approved, two-institutional prospective study. Bariatric patients received MRIs at baseline and after a pre-operative liquid diet. Liver biopsies were performed during surgery and if NAFLD positive, the patients received MRIs at 1, 3, and 6 months...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29213027/-autoimmune-pancreatitis-and-igg4-related-hepatic-inflammatory-pseudotumor-complicated-by-an-impacted-pancreatic-stone-at-the-major-papilla-during-steroid-treatment
#15
Kunio Kataoka, Koichi Achiwa
A 79-year-old male presented to our hospital with abdominal discomfort and was diagnosed with mass-forming pancreatitis. During follow-up, pancreatic stones and a hepatic mass with peripheral bile duct dilation were discovered. Serum IgG4 level was elevated, and a liver tumor biopsy revealed numerous IgG4-positive plasma cells and fibrosis. Chronic pancreatitis with the suspected involvement of autoimmune pancreatitis (AIP) and IgG4-related hepatic inflammatory pseudotumor (IgG4-HIP) was diagnosed. Therefore, a steroid treatment was initiated...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29202802/histopathology-microbiology-and-the-inflammatory-process-associated-with-sarcoptes-scabiei-infection-in-the-iberian-ibex-capra-pyrenaica
#16
José Espinosa, Arián Ráez-Bravo, Jorge R López-Olvera, Jesús M Pérez, Santiago Lavín, Asta Tvarijonaviciute, Francisco J Cano-Manuel, Paulino Fandos, Ramón C Soriguer, José Enrique Granados, Diego Romero, Roser Velarde
BACKGROUND: Sarcoptic mange has been identified as the most significant infectious disease affecting the Iberian ibex (Capra pyrenaica). Despite several studies on the effects of mange on ibex, the pathological and clinical picture derived from sarcoptic mange infestation is still poorly understood. To further knowledge of sarcoptic mange pathology, samples from ibex were evaluated from histological, microbiological and serological perspectives. METHODS: Samples of skin, non-dermal tissues and blood were collected from 54 ibex (25 experimentally infected, 15 naturally infected and 14 healthy)...
December 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29201787/probiotic-therapy-in-patients-with-nonalcoholic-steatohepatitis-in-zagazig-university-hospitals
#17
Sameh M Abdel Monem
Aim: Nonalcoholic fatty liver disease (NAFLD) is probably the most common liver disorder in the world. A subgroup of NAFLD patients is characterized by injury to the hepatocytes and inflammation in addition to excessive fat (steatohepatitis), the latter condition is nominated nonalcoholic steatohepatitis (NASH). This work aimed to evaluate the role of probiotics on the outcome of NASH in patients admitted to the Tropical Medicine Department, Faculty of Medicine, Zagazig University (inpatients and outpatients)...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29198531/laparoscopic-sleeve-gastrectomy-improves-nonalcoholic-fatty-liver-disease-related-liver-damage-in-adolescents-by-reshaping-cellular-interactions-and-hepatic-adipocytokine-production
#18
Valerio Nobili, Guido Carpino, Francesco De Peppo, Romina Caccamo, Antonella Mosca, Ilaria Romito, Diletta Overi, Antonio Franchitto, Paolo Onori, Anna Alisi, Eugenio Gaudio
OBJECTIVES: To investigate whether the modulation of local cellular cross-talks and the modification of hepatic adipocytokine expression could mechanistically explain the improvement of liver histopathology after laparoscopic sleeve gastrectomy (LSG) in adolescents with nonalcoholic fatty liver disease (NAFLD). STUDY DESIGN: Twenty obese (body mass index of ≥35 kg/m2) adolescents who underwent LSG and with biopsy-proven NAFLD were included. At baseline (T0) and 1 year after treatment, patients underwent clinical evaluation, blood tests, and liver biopsy...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29197894/diagnostic-challenge-of-burkitt-s-lymphoma-at-early-age
#19
M H Nor Fauziah, M Z Faizah, C K Loh
A four-year-old Ibanese boy presented with subacute abdominal distension for two months duration. Ultrasound and computed tomography (CT) scan showed solid liver masses as well as bowel and intraperitoneal lesions. Initial diagnosis of intraperitoneal inflammatory process as in tuberculosis with non-liquefied liver abscess with differential diagnosis of neoplastic process was made. Liver biopsy and peritoneal fluid analysis revealed Burkitt's lymphoma (BL). We aim to highlight the diagnostic challenge of BL in this young age group emphasizing on the ultrasound and CT features of intraabdominal BL...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29177608/identification-of-educational-gaps-among-oncologists-who-manage-patients-with-pancreatic-cancer
#20
Justin A Barnes, Melissa L Ellis, Sharon Hwang, Joan Emarine, Patti Merwin, Gregory D Salinas, Benjamin L Musher
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDA) is associated with poor outcomes and presents oncologists with a myriad of clinical challenges. This study was conducted to assess oncologists' practice patterns and to identify the greatest areas of need for future PDA continuing medical education (CME) programs. METHODS: Case vignettes have been validated as an effective tool to assess how physicians approach and treat a wide array of diseases. In order to assess practice patterns for resectable, locally advanced unresectable, and metastatic PDA, an online case vignette survey was distributed to practicing medical oncologists...
November 27, 2017: Journal of Gastrointestinal Cancer
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