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https://www.readbyqxmd.com/read/28302006/transplantation-for-large-liver-tumors-in-the-setting-of-abernethy-malformation
#1
İlgin Özden, Ayşen Yavru, Mine Güllüoğlu, Aydin Alper, Orhan Bilge, Serdar Cantez, Özlem Durmaz
In this study, we report our experiences on the role of transplantation in 2 patients with large liver tumors in the setting of Abernethy malformation. Patient 1 was a 17-year-old boy who was referred for hepatic masses and recurrent hepatic encephalopathy episodes. Computed tomography and magnetic resonance imaging showed 2 large tumors (4 and 8 cm) in the liver. The portal vein drained directly into the vena cava. Core biopsy of the larger mass revealed fibrosis and regenerative hyperplasia. There were hyperintense signals in the T1-weighted images in the globus pallidus...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28299215/intra-abdominal-actinomycosis-mimicking-malignant-abdominal-disease
#2
Ali Ridha, Njideka Oguejiofor, Sarah Al-Abayechi, Emmanuel Njoku
Abdominal actinomycosis is a rare infectious disease, caused by gram positive anaerobic bacteria, that may appear as an abdominal mass and/or abscess (Wagenlehner et al. 2003). This paper presents an unusual case of a hemodynamically stable 80-year-old man who presented to the emergency department with 4 weeks of worsening abdominal pain and swelling. He also complains of a 20-bound weight loss in 2 months. A large tender palpable mass in the right upper quadrant was noted on physical exam. Laboratory studies showed a normal white blood cell count, slightly decreased hemoglobin and hematocrit, and mildly elevated total bilirubin and alkaline phosphatase...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28295504/testosterone-therapy-has-positive-effects-on-anthropometric-measures-metabolic-syndrome-components-obesity-lipid-profile-diabetes-mellitus-control-blood-indices-liver-enzymes-and-prostate-health-indicators-in-elderly-hypogonadal-men
#3
O Canguven, R A Talib, W El Ansari, D-J Yassin, M Salman, A Al-Ansari
To alleviate late-onset hypogonadism, testosterone treatment is offered to suitable patients. Although testosterone treatment is commonly given to late-onset hypogonadism patients, there remains uncertainty about the metabolic effects during follow-ups. We assessed the associations between testosterone treatment and wide range of characteristics that included hormonal, anthropometric, biochemical features. Patients received intramuscular 1,000 mg testosterone undecanoate for 1 year. Patient anthropometric measurements were undertaken at baseline and at each visit, and blood samples were drawn at each visit, prior to the next testosterone undecanoate...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28281521/noninvasive-scoring-system-for-significant-inflammation-related-to-chronic-hepatitis-b
#4
Mei-Zhu Hong, Linglong Ye, Li-Xin Jin, Yan-Dan Ren, Xiao-Fang Yu, Xiao-Bin Liu, Ru-Mian Zhang, Kuangnan Fang, Jin-Shui Pan
Although a liver stiffness measurement-based model can precisely predict significant intrahepatic inflammation, transient elastography is not commonly available in a primary care center. Additionally, high body mass index and bilirubinemia have notable effects on the accuracy of transient elastography. The present study aimed to create a noninvasive scoring system for the prediction of intrahepatic inflammatory activity related to chronic hepatitis B, without the aid of transient elastography. A total of 396 patients with chronic hepatitis B were enrolled in the present study...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279206/mastalgia-as-an-atypical-presentation-of-hepatocellular-carcinoma-a-case-report
#5
AbdulAziz Mohammad Al-Sharydah, Abdulrhman Hamad Al-Abdulwahhab, Ibrahim Abobaker Alghnimi, Mohammed A El Shawarby, Faisal Ahmad Katbi
BACKGROUND: As the incidence of hepatocellular carcinoma (HCC) diagnoses in Saudi Arabia has recently increased due to better diagnostic techniques, the incidence of diagnosed HCC metastasis has also increased. Here, we report a case of HCC metastasis to the rib with an initially atypical presentation of mastalgia caused by extrahepatic metastasis. CASE PRESENTATION: A 31-year-old woman with a prior hepatitis B viral infection presented with a mass in the left breast accompanied by mastalgia for a 6-month duration...
March 9, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28274171/differential-representation-of-liver-proteins-in-obese-human-subjects-suggests-novel-biomarkers-and-promising-targets-for-drug-development-in-obesity
#6
Simonetta Caira, Antonio Iannelli, Rosaria Sciarrillo, Gianluca Picariello, Giovanni Renzone, Andrea Scaloni, Pietro Addeo
The proteome of liver biopsies from human obese (O) subjects has been compared to those of nonobese (NO) subjects using two-dimensional gel electrophoresis (2-DE). Differentially represented proteins were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based peptide mass fingerprinting (PMF) and nanoflow-liquid chromatography coupled to electrospray-tandem mass spectrometry (nLC-ESI-MS/MS). Overall, 61 gene products common to all of the liver biopsies were identified within 65 spots, among which 25 ones were differently represented between O and NO subjects...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28271305/the-validity-of-hcc-diagnosis-codes-in-chronic-hepatitis-b-patients-in-the-veterans-health-administration
#7
Ronald Omino, Sahil Mittal, Jennifer R Kramer, Maneerat Chayanupatkul, Peter Richardson, Fasiha Kanwal
BACKGROUND: Administrative databases that include diagnostic codes are valuable sources of information for research purposes. AIM: To validate diagnostic codes for hepatocellular carcinoma (HCC) in chronic hepatitis B patients. METHODS: We conducted a retrospective study of patients with chronic HBV seen in the national Veterans Administration (VA). HCC cases were identified by the presence of ICD-9 code 155.0. We randomly selected 200 HBV controls without this code as controls...
March 7, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28264852/paritaprevir-and-ritonavir-liver-concentrations-in-rats-as-assessed-by-different-liver-sampling-techniques
#8
Charles S Venuto, Marianthi Markatou, Yvonne Woolwine-Cunningham, Rosemary Furlage, Andrew J Ocque, Robin DiFrancesco, Emily O Dumas, Paul K Wallace, Gene D Morse, Andrew H Talal
Background: The liver is crucial to pharmacology, yet substantial knowledge gaps exist in understanding of its basic pharmacologic processes. Improved understanding in humans requires reliable and reproducible liver sampling methods. We compared liver concentrations of paritaprevir and ritonavir in rats using samples collected by fine needle aspiration (FNA), core needle biopsy (CNB), and surgical resection.Methods: Thirteen Sprague Dawley rats were evaluated, nine who received paritaprevir/ritonavir 30/20-mg/kg by oral gavage daily for 4 to 5 days...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28260461/traumatic-neuroma-causing-biliary-stricture-after-orthotopic-liver-transplant-treated-with-hepaticojejunostomy-a-case-report
#9
Aysen Terzi, Mahir Kirnap, Cigdem Sercan, Gokce Ozdemir, Binnaz Handan Ozdemir, Mehmet Haberal
Traumatic neuromas of the biliary tract have occasionally been reported to cause strictures at the cystic duct stump as a late complication of cholecystectomy with common bile duct exploration. The incidence of symptomatic traumatic biliary neuroma appears to be low after orthotopic liver transplant, as only 25 patients have been described previously in the English-language literature. Traumatic (amputation) neuroma is a reactive proliferation of pericholangial nerve fibers induced by injury, but it is not a true neoplasm...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28228877/hepatic-hodgkin-lymphoma-with-delayed-enhancement-on-ct-and-mri
#10
Yukie Higuma, Ryo Yamauchi, Ritsuko Fujimitsu, Keiko Sakamoto, Yoshinobu Shinagawa, Ayako Morita, Hiroshi Urakawa, Morishige Takeshita, Kengo Yoshimitsu
Hepatic Hodgkin lymphoma is a rare disease, characterized by the presence of abundant granulofibrous stroma, and its radiological features have rarely been described. We report a 67-year-old man, who presented with liver masses that showed apparent delayed enhancement, along with systemic lymphadenopathy and musculoskeletal lesions. Repeated percutaneous needle biopsy, however, failed to confirm the diagnosis, and surgical biopsy finally revealed small amount of Hodgkin cells and Reed-Sternberg cells. In this report, the radiological features of hepatic Hodgkin lymphoma will be presented and discussed, in correlation with its histological findings...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28225987/can-fib4-and-nafld-fibrosis-scores-help-endocrinologists-refer-patients-with-non-alcoholic-fat-liver-disease-to-a-hepatologist
#11
Rodrigo Bremer Nones, Cláudia Pontes Ivantes, Maria Lucia Alves Pedroso
Objective: The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist. Subjects and methods: Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28219122/immunoserological-and-histological-differences-between-autoimmune-hepatitis-with-acute-presentation-and-chronic-autoimmune-hepatitis
#12
Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Shinichi Aishima
BACKGROUND/AIMS: While the histological features in clinically chronic autoimmune hepatitis (AIH) have been well established, with interface hepatitis and plasma cell infiltration as hallmark lesions, the immunoserological and histological features of recent-onset and acute AIH remain undefined. The goal of this study was to define the immunoserological and histological differences between AIH with acute presentation and chronic AIH. METHODS: Thirty-two consecutive patients with well-characterized AIH who had undergone a liver biopsy were identified at our institution...
February 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28206970/genetic-variation-in-long-noncoding-rnas-and-the-risk-of-nonalcoholic-fatty-liver-disease
#13
Silvia Sookoian, Cristian Rohr, Adrián Salatino, Hernán Dopazo, Tomas Fernandez Gianotti, Gustavo O Castaño, Carlos J Pirola
The human transcriptome comprises a myriad of non protein-coding RNA species, including long noncoding RNAs (lncRNAs), which have a remarkable role in transcriptional and epigenetic regulation. We hypothesized that variants in lncRNAs influence the susceptibility to nonalcoholic fatty liver disease (NAFLD). Using next generation sequencing, we performed a survey of genetic variation associated with randomly selected lncRNA-genomic regions located within both experimentally validated and computationally predicted regulatory elements...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28203580/unusual-presentation-of-diffuse-large-b-cell-lymphoma-with-splenic-infarcts
#14
Vivek Kumar, Parita Soni, Vishangi Dave, Jonathan Harris
A 67-year-old man presented with a 3-day history of abdominal pain, fever, and significant weight loss over 2 months. Physical examination revealed left upper quadrant tenderness, hepatomegaly, splenomegaly, and bilateral pitting edema but peripheral lymphadenopathy was absent. Laboratory tests showed anemia, thrombocytopenia, elevated prothrombin time (PT), partial thromboplastin time (PTT), and increased lactate dehydrogenase (LDH). PTT was corrected completely in mixing study. Further workup for the cause of coagulopathy revealed decreased levels of all clotting factors except factor VIII and increase fibrinogen levels, which ruled out disseminated intravascular coagulation (DIC)...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28195103/malignant-melanocytic-neoplasm-of-pancreas-with-liver-metastasis-is-it-malignant-melanoma-or-clear-cell-sarcoma
#15
Thomas Alex Kodiatte, Sam Varghese George, Raju Titus Chacko, Banumathi Ramakrishna
Malignant melanocytic neoplasm, usually seen in soft tissues, is rare in a visceral location and presents as a diagnostic dilemma. We present a case of pancreatic malignant melanocytic neoplasm with liver metastasis. A 58-year-old man presented with left upper abdominal swelling and loss of appetite. Imaging revealed a large mass arising from the pancreatic tail, and this was diagnosed as malignant neoplasm with melanocytic differentiation on biopsy with the possible differentials of malignant melanoma, clear cell sarcoma (CCS), and perivascular epithelioid cell neoplasm...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28179969/composite-lymphoma-opposite-ends-of-spectrum-meet
#16
Uqba Khan, Tarik Hadid, Warda Ibrar, Dahlia Sano, Ayad Al-Katib
An 18-year-old African-American female presented with an episode of syncope. Initial investigations revealed large lung mass with invasion into right atrium along with lesions in kidneys and liver. Patient also developed superior vena cava syndrome due to lung mass. Biopsy of lung mass revealed diagnosis of composite lymphoma with involvement by primary mediastinal B-cell lymphoma (PMBCL) and classical Hodgkin lymphoma. Patient was started on dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (EPOCH-R) with complete response to treatment...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28173830/large-hepatocellular-carcinoma-in-a-non-cirrhotic-liver-with-peritoneal-and-omental-metastasis-in-a-healthy-man-a-case-report
#17
H M M T B Herath, Aruna Kulatunga
BACKGROUND: Liver cancer is the second leading cause of cancer death in men worldwide. Hepatocellular carcinoma usually develops in the setting of cirrhosis or chronic inflammation. Major risk factors for developing hepatocellular carcinoma are chronic hepatitis B or C virus infection, alcoholic cirrhosis, and nonalcoholic fatty liver disease. The most frequent locations for hepatocellular carcinoma to metastasize are the lungs, portal vein, bones, and regional lymph nodes. CASE PRESENTATION: A 41-year-old Sri Lankan man presented with progressive abdominal distension and on examination was found to have a palpable irregular mass in the left lobe of his liver with moderate ascites...
February 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28159237/altered-plasma-lipidome-profile-of-dairy-cows-with-fatty-liver-disease
#18
C Gerspach, S Imhasly, M Gubler, H Naegeli, M Ruetten, E Laczko
Fatty liver disease is a common health problem of dairy cows occurring during the transition from pregnancy to lactation. It is a direct response to fat mobilization due to negative energy balance. Accumulation of lipids in the liver occurs if the uptake of non-esterified fatty acids by the liver exceeds the capacity of lipid oxidation or secretion by the liver. Currently, the diagnosis of fatty liver disease requires confirmation through biopsies to determine the hepatic lipid content. In view of this lack of a practical diagnostic tool, we compared the plasma lipidome of diseased dairy cows using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28155576/diagnosis-of-pseudomyxoma-peritonei-via-endoscopic-ultrasound-guided-fine-needle-aspiration-a-case-report-and-review-of-literature
#19
Umar Darr, Anas Renno, Turki Alkully, Zubair Khan, Abhinav Tiwari, Waleed Zeb, Jenna Purdy, Ali Nawras
INTRODUCTION: Pseudomyxoma peritonei (PMP) is a rare condition caused by mucinous adenocarcinoma cancerous cells that produce abundance of mucin or gelatinous ascites. This cancer can cause tissue fibrosis and can impair normal organ function. Diagnosis can involve multiple imaging modalities including CT scan. There have been few cases of endoscopic ultrasound (EUS) being used as a means for diagnosis of this condition. Here we report a second case of PMP with a previous history of appendectomy diagnosed with EUS guided fine needle aspiration (FNA) biopsy...
February 3, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28151547/sonography-predicts-liver-steatosis-in-patients-with-chronic-hepatitis-b
#20
Erin M Kelly, Vickie A Feldstein, Dustin Etheridge, Rebecca Hudock, Marion G Peters
OBJECTIVES: Liver inflammation and fibrosis may impair the ability of sonography to identify steatosis. We determined the accuracy of sonography in grading steatosis in patients with chronic hepatitis B compared to liver biopsy. METHODS: We conducted was a single-center retrospective study of all nontransplanted patients with chronic hepatitis B undergoing sonography and liver biopsy between 2004 and 2014 (n = 109). Steatosis was graded by sonography as none, mild, moderate, or severe...
February 2, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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