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Vitamin D, diabetes

Aashish Kumar Sharma, R P Agrawal, J K Sharma, Ritvik Agrawal, Surendra Kumar, Kunal Thackar, Kailash Chandra Saini
OBJECTIVE: Vitamin D deficiency may be responsible for endothelial dysfunction which in turn affects the onset and progression of vascular disease including coronary artery disease and its risk factor, directly or indirectly through various mechanisms. This study was undertaken to find out association between vitamin D and endothelial dilatation of brachial artery, which may help to suggest possible underlying mechanisms and may be of clinical importance in planning preventive and therapeutic strategies...
July 2016: Journal of the Association of Physicians of India
Veronica T Boyle, Eric B Thorstensen, David Mourath, M Beatrix Jones, Lesley M E McCowan, Louise C Kenny, Philip N Baker
Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study...
October 18, 2016: British Journal of Nutrition
Maria Felicia Faienza, Annamaria Ventura, Maurizio Delvecchio, Anna Fusillo, Laura Piacente, Gabriella Aceto, Graziana Colaianni, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
CONTEXT: Childhood type 1 diabetes (T1DM) is associated with decreased bone mass. Sclerostin and dickkopf-1 (DKK-1) are Wnt inhibitors which regulate bone formation. OBJECTIVE: To evaluate sclerostin and DKK-1 levels in TD1M children and to analyze the influence of the glycaemic control on bone health. DESIGN AND SETTING: Cross-sectional study conducted at a clinical research center. Partecipants: One hundred and six T1DM subjects (12.2 ± 4 years), 66 on multiple daily injections (MDI) and 40 on continuous subcutaneous infusion of insulin (CSII), and 80 controls...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Manish, Nitin Malhotra
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
E Dinesh Ragav, Mamatha B Patil
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Nilesh Machhindra Jagdale
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Sourabh Jain, Anurag Chaurasia, Shailendra Manjhvar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Srikrishna Raghavendra Boddu, Veena Vedartham, Rama Bhat
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Jayanta Chakraborty, Debdatta Kar, Semanti Chakraborty, Rita Moitra, Chanchal Samanta
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Durga Prasad Singh, Prashant Prakash, Pradeep K Maheshwari
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Guo-Tao Pan, Jian-Feng Guo, Shao-Lin Mei, Meng-Xi Zhang, Zhi-Yong Hu, Chong-Ke Zhong, Chang-You Zeng, Xiao-Hong Liu, Qing-Hua Ma, Bing-Yan Li, Li-Qiang Qin, Zeng-Li Zhang
Vitamin D deficiency is highly prevalent all over the world and dietary intakes of vitamin D are very low in China. In this study we aimed to determine whether vitamin D deficiency is associated with increased risk of metabolic syndrome (MetS) among Chinese type 2 diabetes mellitus (T2DM) patients aged over 50 y. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured in a cross-sectional sample of 270 T2DM patients aged over 50 y from Zhejiang. Data on demographic characteristics, anthropometry and other variables were collected...
2016: Journal of Nutritional Science and Vitaminology
Lamia Ysmail-Dahlouk, Wafa Nouari, Mourad Aribi
BACKGROUND: Type 1 diabetes (T1D) is associated with an imbalance between inflammation and repair. Recently, the biologically active form of vitamin D3, i.e. 1,25(OH)2D3, has been reported to have potent immunomodulatory effects on both innate and adaptive immune cells, as well as on the production of their specific cytokines. METHODS: We examined the effect of 1,25(OH)2D3 on the production of proinflammatory Th1/Th17 and anti-inflammatory Th2/Treg related cytokines, as well as on the phosphorylation of monocyte-expressed STAT4 and STAT6 at the recent-onset human T1D...
October 4, 2016: Immunology Letters
Tracy S Moreira-Lucas, Alison M Duncan, Remi Rabasa-Lhoret, Reinhold Vieth, Alison L Gibbs, Alaa Badawi, Thomas Ms Wolever
AIMS: Low serum 25-hydroxyvitamin-D [25(OH)D] concentrations are associated with insulin resistance, β-cell dysfunction and type 2 diabetes. We conducted a 24-week double-blind, randomized, placebo-controlled trial to examine the effect of 28 000 IU of vitamin D3 once weekly on plasma glucose after a 2h-75g oral glucose tolerance test (2hrPC glucose), insulin sensitivity and β-cell function. DESIGN: Seventy-one participants with serum 25(OH)D ≤65 nmol/L, impaired fasting glucose, and elevated glycated hemoglobin were randomly assigned to receive 28 000 IU of vitamin D3 (VitD; n = 35) or placebo (n = 36) in cheese once weekly for 24 weeks...
September 26, 2016: Diabetes, Obesity & Metabolism
E L Wu, H X Cui
The prevention and treatment of type-2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), which are disorders with high incidence rates, is of primary importance. In this study, we analyzed the effect of 1,25-(OH)2D3 and lipopolysaccharide (LPS) in combination with interleukin (IL)-15 on the inflammatory immune response and expression of vitamin D receptor (VDR) in mononuclear cells of T2DM and DN uremia (DNU) patients. The human acute monocytic leukemia cell line THP-1 was treated with peripheral blood serum isolated from 30 healthy controls and T2DM and DNU patients each, cultured in the presence or absence of 1,25-(OH)2D3, and subsequently treated with LPS and IL-15...
August 29, 2016: Genetics and Molecular Research: GMR
Levent Cerit, Hatice Kemal, Kamil Gulsen, Barcin Ozcem, Zeynep Cerit, Hamza Duygu
BACKGROUND: Vitamin D deficiency is associated with many diverse cardiovascular disorders, such as hypertension, heart failure, stroke, coronary artery disease and atrial fibrillation. The relationship between Vitamin D and the development of atrial fibrillation after coronary artery bypass surgery (CABG) has not been studied. Therefore, we assessed the relationship between Vitamin D and the development of postoperative atrial fibrillation (POAF) after CABG. METHODS: Medical records of consecutive patients who underwent CABG surgery were retrospectively reviewed for the development of atrial fibrillation in the postoperative period...
August 2, 2016: Cardiovascular Journal of Africa
Hyun Yoon, Dae Jung Jeon, Chang Eun Park, Hye Sook You, Ae Eun Moon
The purpose of this study is to look at these relationships in non-diabetic Korean adults. This study was based on data from the KNHANES V-1, which is representative of the population of Korea. A total of 5,492 participants (≥20 years in age) without type 1 or type 2 diabetes, assessed for serum 25-hydroxyvitamin D [25(OH)D], fasting blood glucose and insulin, as well as anthropometric variables, were included in the analyses. The key study results were as follows: First, vitamin D status [vitamin D deficient, 25(OH)D <25 nM; vitamin D insufficient, 25(OH)D ≥25, <50 nM; vitamin D sufficient, 25(OH)D ≥50 nM] was inversely associated with homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in model 2 (adjusted for age and gender) and 3 (further adjusted for smoking, alcohol drinking, regular exercise, systolic and diastolic blood pressure, waist circumference, and body mass index)...
September 2016: Journal of Clinical Biochemistry and Nutrition
Coskun U Oruc, Yunus E Akpinar, Shirkhan Amikishiyev, Ayse Kubat Uzum, Artur Salmaslioglu, Figen Gurdol, Beyhan Omer
OBJECTIVES: Recent research has shown that hypovitaminosis D may increase the risk of hypertension, vascular disease, diabetes mellitus, obesity and metabolic syndrome (MetS). Endothelial dysfunction (ED) is one of the key components of MetS which is associated with an imbalance between vasoactive substances such as nitric oxide (NO) and endothelins (ET). In this study, we assessed the association of 25(OH) D3 level with endothelial dysfunction and subclinical atherosclerosis in MetS patients...
October 2, 2016: Current Vascular Pharmacology
C S Hansen, J Fleischer, D Vistisen, M Ridderstråle, J S Jensen, M E Jørgensen
AIM: To investigate the possible association between vitamin D deficiency and cardiovascular autonomic neuropathy in people with diabetes. METHODS: A total of 113 people with Type 1 or Type 2 diabetes [mean (interquartile range) diabetes duration 22.0 (12-31) years, mean (sd) age 56.2 (13.0) years, 58% men] underwent vitamin D (D2 and D3) assessment, and were screened for cardiovascular autonomic neuropathy using three cardiovascular reflex tests [heart rate response to deep breathing (E/I ratio), to standing (30/15 ratio) and to the Valsalva manoeuvre] and assessment of 5-min resting heart rate and heart rate variability indices...
October 1, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
Piotr Domaracki, Pawel Sadlecki, Grazyna Odrowaz-Sypniewska, Ewa Dzikowska, Pawel Walentowicz, Joanna Siodmiak, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
BACKGROUND: An association between the level of vitamin D and the risk of pregnancy-related complications remains unclear. The aim of this study was to examine concentrations of 25(OH) vitamin D in Polish women with normal pregnancies and pregnancies complicated by gestational hypertension, preeclampsia or gestational diabetes mellitus (GDM). Moreover, we analyzed an association between maternal serum 25(OH)D and the risk of gestational hypertension, preeclampsia and GDM. MATERIAL AND METHODS: The study included 207 pregnant women, among them 171 with pregnancy-related complications: gestational hypertension (n = 45), preeclampsia (n = 23) or GDM (n = 103)...
2016: International Journal of Molecular Sciences
Negar Naderpoor, Aya Mousa, Maximilian P J de Courten, Robert Scragg, Sanjeeva Ranasinha, Barbora de Courten
Evidence from observational studies indicates a role for vitamin D in kidney function and progression to chronic kidney disease. Findings from animal studies have proposed underlying mechanisms including increased activation of the renin-angiotensin system, increased blood pressure, insulin resistance and chronic low-grade inflammation. However, human studies are limited by confounders arising from heterogeneous samples of participants. We examined the relationship between 25(OH)D and estimated glomerular filtration rate (eGFR) in a predominantly obese otherwise healthy and drug-naive population with no history of chronic kidney disease (CKD)...
September 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
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