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Vitamin D, diabetes

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https://www.readbyqxmd.com/read/28822353/vdr-gene-variation-and-insulin-resistance-related-diseases
#1
Fei-Fei Han, Ya-Li Lv, Li-Li Gong, He Liu, Zi-Rui Wan, Li-Hong Liu
BACKGROUND: Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed vitamin D receptor (VDR) gene polymorphism in relationship with these diseases; however, results remain inconsistent. Our study was conducted to elucidate whether VDR Gene polymorphisms could predict insulin resistance on a large scale. METHODS: A meta-analysis using MEDLINE and EMBASE, was performed up to December 16th, 2016...
August 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28822064/evolution-of-29-anthropometric-nutritional-and-cardiometabolic-parameters-among-morbidly-obese-adolescents-2-years-post-sleeve-gastrectomy
#2
Wahiba Elhag, Walid El Ansari, Sama Abdulrazzaq, Ali Abdullah, Mohamed Elsherif, Israa Elgenaied
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is a popular treatment for adolescent morbid obesity. Research on LSG outcomes among adolescents assessed a narrow range of anthropometric, nutritional, or cardiometabolic parameters, leading to an incomplete picture of these changes. We examined a wide variety of anthropometric, nutritional, and cardiometabolic parameters among adolescents before and after LSG. METHODS: We retrospectively reviewed medical charts of all obese adolescents who underwent LSG at Hamad Medical Corporation, Qatar, between January 2011 and June 2015 (N = 102)...
August 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28817241/association-between-vitamin-d-deficiency-and-heart-failure-risk-in-the-elderly
#3
Catarina Magalhães Porto, Vanessa De Lima Silva, João Soares Brito da Luz, Brivaldo Markman Filho, Vera Magalhães da Silveira
AIMS: The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics. METHODS AND RESULTS: A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia...
August 17, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28815786/vitamin-d-intake-during-the-first-4-years-and-onset-of-asthma-by-age-5-a-nested-case-control-study
#4
Bright I Nwaru, Kishor Hadkhale, Niina Hämäläinen, Hanna-Mari Takkinen, Suvi Ahonen, Jorma Ilonen, Jorma Toppari, Onni Niemelä, Anna-Maija Haapala, Riitta Veijola, Mikael Knip, Suvi M Virtanen
BACKGROUND: Early life vitamin D intake has been linked to asthma risk in childhood, but the role of longitudinal vitamin D exposure has not been previously evaluated. We investigated the association between vitamin D intake during the first 4 years of life and asthma risk by age 5. METHODS: Within a Finnish population-based birth cohort, 182 incident asthma cases were matched to 728 controls on sex, genetic risk for type 1 diabetes, delivery hospital, and time of birth...
August 17, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28811597/vitamin-d-receptor-gene-polymorphisms-modify-cardiometabolic-response-to-vitamin-d-supplementation-in-t2dm-patients
#5
Nasser M Al-Daghri, Abdul Khader Mohammed, Omar S Al-Attas, Mohammed Ghouse Ahmed Ansari, Kaiser Wani, Syed D Hussain, Shaun Sabico, Gyanendra Tripathi, Majed S Alokail
There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808645/effect-of-vitamin-d-supplementation-on-the-incidence-of-gestational-diabetes
#6
Hatav Ghasemi Tehrani, Fatemeh Mostajeran, Behnaz Banihashemi
BACKGROUND: The aim of this study was survey of the effect of Vitamin D supplementation on the incidence of gestational diabetes (GDM) in pregnant women. MATERIALS AND METHODS: This randomized clinical trial was conducted at Alzahra and Shahid Beheshti Hospital in Isfahan, Iran, from January, 2013 to January, 2014 on 210 pregnant women referred to gynecology clinics. Serum levels of Vitamin D were measured, and those with lower serum levels of 10 nmol/L randomly divided into two groups of A and B...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28803595/vitamin-d-intake-and-risk-of-cvd-and-all-cause-mortality-evidence-from-the-caerphilly-prospective-cohort-study
#7
Jing Guo, John R Cockcroft, Peter C Elwood, Janet E Pickering, Julie A Lovegrove, David I Givens
OBJECTIVE: Prospective data on the associations between vitamin D intake and risk of CVD and all-cause mortality are limited and inconclusive. The aim of the present study was to investigate the associations between vitamin D intake and CVD risk and all-cause mortality in the Caerphilly Prospective Cohort Study. DESIGN: The associations of vitamin D intake with CVD risk markers were examined cross-sectionally at baseline and longitudinally at 5-year, 10-year and >20-year follow-ups...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28794851/expression-of-jazf1-abcc8-kcnj11and-notch2-genes-and-vitamin-d-receptor-polymorphisms-in-type-2-diabetes-and-their-association-with-microvascular-complications
#8
Maha A Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M Raslan, Omneya M Saleh
BACKGROUND: We studied JAZF1, ABCC8, KCNJ11and Notch2 gene expression and vitamin D receptor (VDR) polymorphisms (Fok1 and Bsm1) in patients with type 2 diabetes mellitus (T2DM) and tried to find out their association with microvascular complications in these patients. METHODS: The study was conducted on 180 patients (93 complicated and 87 noncomplicated) and 150 healthy subjects. Reverse-transcriptase polymerase chain reaction (RT-PCR) was used to assess gene expression and real-time PCR was used to detect VDR genotypes...
June 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28794211/dietary-whole-egg-consumption-attenuates-body-weight-gain-and-is-more-effective-than-supplemental-cholecalciferol-in-maintaining-vitamin-d-balance-in-type-2-diabetic-rats
#9
Cassondra J Saande, Samantha K Jones, Kaylee E Hahn, Carter H Reed, Matthew J Rowling, Kevin L Schalinske
Background: Type 2 diabetes (T2D) is characterized by vitamin D insufficiency owing to excessive urinary loss of 25-hydroxycholecalciferol [25(OH)D]. We previously reported that a diet containing dried whole egg, a rich source of vitamin D, was effective at maintaining circulating 25(OH)D concentrations in rats with T2D. Furthermore, whole egg consumption reduced body weight gain in rats with T2D.Objective: This study was conducted to compare whole egg consumption with supplemental cholecalciferol with respect to vitamin D balance, weight gain, and body composition in rats with T2D...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28790917/effect-of-dipeptidyl-peptidase-4-inhibitors-on-bone-metabolism-and-the-possible-underlying-mechanisms
#10
REVIEW
Yinqiu Yang, Chenhe Zhao, Jing Liang, Mingxiang Yu, Xinhua Qu
Diabetes mellitus has been demonstrated to be closely associated with osteoporosis. Accordingly, hypoglycemic therapy is considered effective in treating metabolic bone disease. Recently, the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors, a new type of antidiabetic drug, on bone metabolism have been widely studied. This review mainly describes the effects of DPP-4 inhibitors on bone metabolism, including their effects on bone mineral density, bone quality, and fracture risk. In addition, the potential underlying mechanisms are discussed...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28772062/assessment-of-a-national-diabetes-education-program-diabetes-prevention-toolkit-the-d2d-experience
#11
Roshni Devchand, Patricia Sheehan, Joanne M Gallivan, Diane M Tuncer, Christina Nicols
BACKGROUND AND PURPOSE: The National Diabetes Education Program created the Small Steps. Big Rewards. GAME PLAN. toolkit to deliver basic type 2 diabetes prevention information to individuals at risk. The purpose of this study is to test the impact of GAME PLAN on diabetes prevention knowledge and behavioral readiness in the vitamin D and type 2 diabetes (D2d) study and participant satisfaction with toolkit materials. METHODS: Three hundred sixty adults at risk for diabetes participating in the D2d study were enrolled...
August 3, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28770950/prevention-of-neural-tube-defects-and-maternal-gestational-diabetes-through-the-inositol-supplementation-preliminary-results
#12
D Dell'Edera, F Sarlo, A Allegretti, A A Epifania, F Simone, M G Lupo, M Benedetto, M R D'Apice, A Capalbo
OBJECTIVE: Our study aims to demonstrate that the use in the preconceptional period until the 24th week of pregnancy of inositol and folic acid, first of all, preserves the product of conception from neural tube defects (NTDs) and then, thanks to inositol supplementation, it possibly counteracts and prevents the onset of maternal gestational diabetes (GDM). PATIENTS AND METHODS: We have collected data derived from pregnant women arrived at our laboratory, from January 2014 to January 2016, with no family history of type 2 diabetes and hypertension...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28768837/vitamin-d-in-the-spectrum-of-prediabetes-and-cardiovascular-autonomic-dysfunction
#13
REVIEW
Rumyana Dimova, Tsvetalina Tankova, Nevena Chakarova
Vitamin D is a fat-soluble secosteroid hormone with pleiotropic effects. 1,25-Dihydroxyvitamin D coordinates the biosynthesis of neurotransmitters in the central nervous system, which regulate cardiovascular autonomic function and may explain its putative role in the development of cardiovascular autonomic neuropathy (CAN). CAN is an independent risk factor for mortality in patients with diabetes and prediabetes and is associated with an increased risk of developing type 2 diabetes and cardiovascular disease...
August 2, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28768407/the-big-vitamin-d-mistake
#14
Dimitrios T Papadimitriou
Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities' decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L...
July 2017: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/28768342/correction-the-effects-of-vitamin-d-supplementation-on-glucose-metabolism-and-lipid-profiles-in-patients-with-gestational-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
Maryam Akbari, Mahmood Moosazadeh, Kamran B Lankarani, Reza Tabrizi, Mansooreh Samimi, Maryam Karamali, Mehri Jamilian, Fariba Kolahdooz, Zatollah Asemi
No abstract text is available yet for this article.
August 2, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28766735/relationship-between-tooth-loss-and-peripheral-arterial-disease-among-women
#16
Francisco J Muñoz-Torres, Kenneth J Mukamal, Jennifer K Pai, Walter Willett, Kaumudi J Joshipura
AIM: We assessed the longitudinal association between tooth loss and peripheral arterial disease (PAD) within the Nurses' Health Study. MATERIALS AND METHODS: After excluding participants with prior cardiovascular diseases, 277 out of 79,680 women were confirmed as PAD cases during 16-years of follow-up. Number of teeth and recent tooth loss were reported initially in 1992. Subsequent tooth loss was recorded in 1996 and in 2000. We evaluated the associations of baseline number of teeth and recent tooth loss with risk of PAD, adjusting for age, smoking, diabetes, hypertension, high cholesterol, aspirin use, family history of myocardial infarction, BMI, alcohol consumption, physical activity, post-menopausal hormone use, and use of vitamin E, vitamin D, multivitamin, and calcium...
August 2, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28759943/the-effects-of-vitamin-d-supplementation-on-glucose-metabolism-and-lipid-profiles-in-patients-with-gestational-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#17
Maryam Akbari, Mahmood Moosazadeh, Kamran B Lankarani, Reza Tabrizi, Mansooreh Samimi, Maryam Karamali, Mehri Jamilian, Fariba Kolahdooz, Zatollah Asemi
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes (GDM) patients. We conducted an electronic systematic search of MEDLINE, and 4 other research databases from inception to August 2016, in addition to performing hand searches and consulting with experts in the field. The index of heterogeneity between studies was determined using Cochran (Q) and I-squared tests...
July 31, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28751957/vitamin-d-levels-in-subjects-with-or-without-chronic-kidney-disease-among-veterans-with-diabetes-in-north-east-united-states
#18
Subhashini Yaturu, Barbara Youngberg, Sonya Zdunek
AIM: To evaluate the prevalence of vitamin D deficiency and its relation to diabetes and kidney disease in Veterans residing in the North East United States (VISN 2). METHODS: In this retrospective study, we used data from the computerized patient record system at Stratton Veterans Administration Medical Center at Albany, NY (VHA) for those patients who had 25-hydroxyvitamin D levels and 1,25 (OH) vitamin D levels measured between 2007 and 2010. We collected demographic information including age, sex, body mass index and race; clinical data including diabetes, hypertension and CAD; and laboratory data including calcium, creatinine and parathyroid hormone (PTH) (intact)...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28749418/the-association-between-vitamin-d-insufficiency-and-nonalcoholic-fatty-liver-disease-a-population-based-study
#19
Yeonjung Ha, Seong Gyu Hwang, Kyu Sung Rim
Previous studies have shown inconsistent results regarding the association between vitamin D insufficiency and nonalcoholic fatty liver disease (NAFLD). We attempted to demonstrate this relationship using population-based data. Vitamin D insufficiency was defined as a 25(OH)D level ≤20 ng/mL. Hepatic steatosis index was calculated to define NAFLD. Significant fibrosis was assessed using Body mass index, AST/ALT Ratio, Diabetes (BARD) score. Logistic regression analyses were performed to determine the relationship between vitamin D insufficiency and NAFLD...
July 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28749117/roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-a-narrative-review-of-risks-and-benefits
#20
Matthew D Ettleson, Corey J Lager, Andrew T Kraftson, Nazanene H Esfandiari, Elif A Oral
INTRODUCTION: Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) are the most commonly performed metabolic surgeries and are highly effective for the treatment of obesity and related comorbidities. In this narrative review, recent studies of at least two years of follow-up directly comparing outcomes between GB and SG are reviewed to assess the efficacy of each procedure in weight loss and diabetes remission, as well as resulting quality of life (QoL) assessment and micronutrient deficiencies...
July 26, 2017: Minerva Chirurgica
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