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Vitamin D, diabetes

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https://www.readbyqxmd.com/read/29920123/effects-of-%C3%AE-glucan-and-vitamin-d-supplementation-on-inflammatory-parameters-in-patients-with-diabetic-retinopathy
#1
Josef Richter, Martina Závorková, Vaclav Vetvicka, Ivana Liehneová, Vlastimil Kral, Lucie Rajnohova Dobiasova
The objective of this article is to evaluate the potential effects of beta-glucan and vitamin D supplementation in patients with diabetic retinopathy. We evaluated the levels of several parameters of inflammatory reactions (C-reactive protein [CRP], serum amyloid A [SAA], and interleukin- [IL-] 6), leptin, and vitamin D. Using a 3-month interval, we divided the patients into three groups: (1) supplemented with beta-glucan and vitamin D, (2) supplemented with vitamin D and placebo, and (3) supplemented with vitamin D alone...
June 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29916137/high-serum-osteopontin-levels-are-associated-with-prevalent-fractures-and-worse-lipid-profile-in-post-menopausal-women-with-type-2-diabetes
#2
T Filardi, V Carnevale, R Massoud, C Russo, L Nieddu, F Tavaglione, I Turinese, A Lenzi, E Romagnoli, S Morano
PURPOSE: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. METHODS: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3...
June 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29915661/multifactorial-aetiology-for-non-uremic-calciphylaxis-a-case-report
#3
Sijan Basnet, Niranjan Tachamo, Rashmi Dhital, Biswaraj Tharu
Calciphylaxis is commonly associated with end-stage renal disease patients on haemodialysis. We present a rare case of calciphylaxis in a non-uremic patient. The diagnosis was made clinically and confirmed with skin biopsy showing calcification of the dermal and subcutaneous tissues in the von Kossa stain. We believe that the combination of uncontrolled diabetes mellitus, a non-functioning paraganglioma and vitamin D deficiency in a susceptible female patient was responsible for causing calciphylaxis in our patient...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29914670/supplementation-of-oat-avena-sativa-l-extract-abates-alcohol-induced-acute-liver-injury-in-a-mouse-model
#4
Salma Mukhtar Mir, Bidya Dhar Sahu, Meghana Koneru, Madhusudana Kuncha, Mahesh Kumar Jerald, Halley Gora Ravuri, Sanjit Kanjilal, Ramakrishna Sistla
Dietary supplementation of oats has been associated with reduced risk of cardiovascular disease, diabetes, and gastrointestinal disorders. The role of oat extract as prophylactic in treating acute liver injury is not thoroughly established. We, therefore, hypothesized that oat extract would exert protective effect against alcohol-induced acute liver injury in a mouse model. To test this hypothesis, male C57BL/6 mice were pretreated with phenolic-enriched ethyl acetate (EA) fraction of oats (prepared by fractionating aqueous ethanolic extract with solvents of increasing polarity) at dosages of 125 and 250 mg kg-1 d-1 for 12 consecutive days...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29914667/methylation-in-3-near-region-of-gc-gene-and-its-association-with-the-level-of-vitamin-d-binding-protein-and-type-2-diabetes-mellitus
#5
Songcheng Yu, Yan Wang, Xing Li, Zhenxing Mao, Fei Yu, Ling Wang, Yue Ba, Chongjian Wang, Wenjie Li
As the major vitamin D binding protein (DBP), the group-specific component (GC) plays an important role in the bioactivity of vitamin D. Abnormal expression of GC gene may be associated with vitamin D related disease, type 2 diabetes mellitus (T2DM). DNA methylation is an important regulator of gene expression. It has been reported that methylation in 3' untranslated region played a role in regulation of protein expression via interaction with miRNA. This study hypothesized that DNA methylation of 3' near region of GC gene (3'GC) might be associated with T2DM...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29911037/prevalence-pattern-of-key-polymorphisms-in-the-vitamin-d-receptor-gene-among-patients-of-type-2-diabetes-mellitus-in-northeast-india
#6
Dipti Sarma, Vikram Singh Chauhan, Kandarpa Kumar Saikia, Partha Sarma, Sukanta Nath
Aims: To investigate the association between Vitamin D receptor gene polymorphisms (BsmI, TaqI and FokI) and type 2 diabetes mellitus in patients in north eastern India. Settings and Design: This was a case control study with 40 cases of type 2 diabetes and 20 controls. Materials and Methods: Genomic DNA was extracted from blood and genotyped for the single nucleotide polymorphism (SNPs) of BsmI [rs1544410], TaqI [rs731236] and FokI [rs2228570] by polymerase chain reaction and gene sequencing...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29909574/the-possible-antidiabetic-effects-of-vitamin-d-receptors-agonist-in-rat-model-of-type-2-diabetes
#7
Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel
Vitamin D3 deficiency was found to be tightly linked to many health problems including metabolic syndrome, cancer, cardiovascular diseases, and type 2 diabetes mellitus. In our study, we tested the possible antidiabetic effects of one of vitamin D3 analogs, alfacalcidol, solely or in a combination with metformin on type 2 diabetic rats. Type 2 diabetic model rats were induced by feeding high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin. In addition to the control group, the diabetic rats were divided into four groups: untreated, metformin-treated, alfacalcidol-treated, and combination-treated group (metformin + alfacalcidol) for 4 weeks...
June 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29904613/prevalence-of-musculoskeletal-pain-in-association-with-serum-25-hydroxyvitamin-d-concentrations-in-patients-with-type-2-diabetes-mellitus
#8
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
The aim of the present study was to investigate the prevalence of musculoskeletal pain in patients with type 2 diabetes mellitus (T2DM) in association with 25-hydroxyvitamin D levels, anxiety, depression and neuropathy. A cross-sectional study was conducted involving a total of 124 T2DM patients. Musculoskeletal pain was determined by self-reporting of painful body sites. Pain intensity was assessed using a scale of 0-10. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Neuropathy was assessed using the PainDETECT questionnaire...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29904370/vitamin-d-supplementation-guidelines-for-general-population-and-groups-at-risk-of-vitamin-d-deficiency-in-poland-recommendations-of-the-polish-society-of-pediatric-endocrinology-and-diabetes-and-the-expert-panel-with-participation-of-national-specialist-consultants
#9
REVIEW
Agnieszka Rusińska, Paweł Płudowski, Mieczysław Walczak, Maria K Borszewska-Kornacka, Artur Bossowski, Danuta Chlebna-Sokół, Justyna Czech-Kowalska, Anna Dobrzańska, Edward Franek, Ewa Helwich, Teresa Jackowska, Maria A Kalina, Jerzy Konstantynowicz, Janusz Książyk, Andrzej Lewiński, Jacek Łukaszkiewicz, Ewa Marcinowska-Suchowierska, Artur Mazur, Izabela Michałus, Jarosław Peregud-Pogorzelski, Hanna Romanowska, Marek Ruchała, Piotr Socha, Mieczysław Szalecki, Mirosław Wielgoś, Danuta Zwolińska, Arkadiusz Zygmunt
Introduction: Vitamin D deficiency is an important public health problem worldwide. Vitamin D deficiency confers a significant risk for both skeletal and non-skeletal disorders and a number of lifelong negative health outcomes. The objectives of this evidence-based guidelines document are to provide health care professionals in Poland, an updated recommendation for the prevention, diagnosis and treatment of vitamin D deficiency. Methods: A systematic literature search examining the prevention and treatment strategies for vitamin D deficiency was conducted...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29903667/-the-most-common-stopp-start-criteria-in-spain-a-review-of-the-literature
#10
Esther Salgueiro, Bryana Candelaria Elizarde, Ana Isabel Elola, Beatriz García-Pulido, María Luisa Nicieza-García, Gloria Manso
OBJECTIVE: To analyse STOPP/START criteria found most frequently in the studies carried out in Spain, in order to identify the main areas of potentially inappropriate prescribing. METHODS: A literature review was carried out on the original studies performed in Spain that applied the original version of the STOPP/START criteria and that described the most common STOPP and/or START criteria found. In each study, a weighted analysis was performed on the criteria found, by assigning 5 points to the criterion in first position, 4 points to the criterion in second position, and so on to fifth criterion...
June 11, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29900162/association-of-insulin-resistance-with-lower-bone-volume-and-strength-index-of-the-proximal-femur-in-nondiabetic-postmenopausal-women
#11
Jaewon Yang, Namki Hong, Jee-Seon Shim, Yumie Rhee, Hyeon Chang Kim
Background: Type 2 diabetes mellitus is associated with an increased risk of osteoporotic fracture despite relatively preserved bone mineral density (BMD). Although this paradox might be attributed to the influence of insulin resistance (IR) on bone structure and material properties, the association of IR with femur bone geometry and strength indices remains unclear. Methods: Using data from the Cardiovascular and Metabolic Disease Etiology Research Center cohort study, we conducted a cross-sectional analysis among nondiabetic postmenopausal women...
May 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29893142/microangiopathy-is-associated-with-bone-loss-in-female-type-2-diabetes-mellitus-patients
#12
Ni Zhong, Youyang Zhang, Xiangling Pu, Bei Xu, Mingxin Xu, Haidong Cai, Ge Zhang, Ran Cui, Hui Sheng, Shen Qu
OBJECTIVE: Type 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. METHODS: A total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg)...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29893137/dietary-intake-and-micronutrient-supplementation-in-youth-with-celiac-disease-with-and-without-type-1-diabetes
#13
Amanda Liu, Margaret Marcon, Esther Assor, Farid H Mahmud, Justine Turner, Diana Mager
The study purpose was to describe dietary intake and the factors influencing micronutrient supplements (MS) use in Celiac Disease (CD) ± Type 1 Diabetes (T1D). Three-day food records collected from parents of youth (3-18 years) with CD (n = 14) ± T1D (n = 10) were assessed for macro and micronutrient intake, diet quality (DQ), glycemic index (GI), glycemic load (GL), and food group intake. Focus group methodology and thematic concept analysis were conducted to determine factors influencing adolescent MS use...
June 12, 2018: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/29892562/impact-of-vitamin-d-treatment-on-25-hydroxy-vitamin-d-levels-and-insulin-homeostasis-in-obese-african-american-adolescents-in-a-randomized-trial
#14
Usha Sethuraman, Marwan A Zidan, Lynae Hanks, Minoo Bagheri, Ambika Ashraf
Background: Obesity is affecting children in epidemic proportions in the United States with nearly 25% of children being obese. Consequences of obesity including dyslipidemia, type 2 diabetes and cardiovascular disease are leading to morbidity at younger ages. Parallel to the obesity and diabetes epidemics, the prevalence of vitamin D deficiency has reached very high levels and has been associated with insulin resistance and dyslipidemia. Studies exploring the impact of vitamin D repletion on insulin sensitivity and dyslipidemia in children are sparse...
June 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29891745/effects-of-high-dose-vitamin-e-supplementation-on-markers-of-cardiometabolic-risk-and-oxidative-stress-in-patients-with-diabetic-nephropathy-a-randomized-double-blinded-controlled-trial
#15
Esmat Aghadavod, Alireza Soleimani, Gholamali Hamidi, Fariba Keneshlou, Akbar Heidari, Zatollah Asemi
INTRODUCTION: Patients with diabetic nephropathy (DN) may benefit from vitamin E's antilipid and antioxidant activities. This study aimed to evaluate the effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with DN. MATERIALS AND METHODS: This randomized controlled trial was carried out on 54 patients with DN that were randomly divided into 2 groups to receive vitamin E supplement (800 IU/d) or placebo for 12 weeks...
May 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29888290/vitamin-d-binding-protein-clearance-ratio-is-significantly-associated-with-glycemic-status-and-diabetes-complications-in-a-predominantly-vitamin-d-deficient-population
#16
Nabila A Abdella, Olusegun A Mojiminiyi
Introduction: Studies have shown increased urine excretion of vitamin D-binding protein (VDBP) in patients with diabetic nephropathy (DN) resulting from postulated mechanisms linked to renal tubular damage. In this study, we evaluate the utility of VDBP clearance ratio as a novel determinant of glycemic status, DN, and other diabetes-associated complications. Methods: Levels of vitamin D, HbA1c, serum, urine concentrations of VDBP, and creatinine were measured in 309 subjects...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29885163/efficacy-of-oral-vitamin-d-on-glycated-haemoglobin-hba1c-in-type-2-diabetics-having-vitamin-d-deficiency-a-randomized-controlled-trial
#17
Dur Muhammad Khan, Asif Jamil, Fawad Ahmad Randhawa, Nasir Farooq Butt, Uzma Malik
OBJECTIVE: To study the efficacy of oral vitamin D in improving glycaemic control of patients with type 2 diabetes by reducing glycated haemoglobin levels. METHODS: This randomised control trial was carried out at Mayo Hospital, Lahore, from February 5 to August 5, 2016, and comprised type 2 diabetes patients aged 40-70 years visiting the outpatient clinics. They were randomly divided into two groups by using the lottery method. Group A received oral vitamin D along with metformin and group B received metformin only...
May 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29883970/the-effects-of-vitamin-d-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-in-diabetic-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#18
Mohammad Ali Mansournia, Vahidreza Ostadmohammadi, Amin Doosti-Irani, Majid Ghayour-Mobarhan, Gordon Ferns, Hossein Akbari, Amir Ghaderi, Hamid Reza Talari, Zatollah Asemi
In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI)...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883217/association-between-vitamin-d-status-and-hyperinsulinism
#19
Catherine McCormack, Shalem Leemaqz, Denise Furness, Gustaaf Dekker, Claire Roberts
AIMS: Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes. Hyperinsulinism is also thought to increase miscarriages. We investigated the association between vitamin D levels and hyperinsulinism in a cohort of recurrent miscarriage patients. METHODS: Patients undergoing miscarriage investigations had insulin and vitamin D levels tested...
June 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29875736/deconvoluting-the-biological-roles-of-vitamin-d-binding-protein-during-pregnancy-a-both-clinical-and-theoretical-challenge
#20
REVIEW
Spyridon N Karras, Theocharis Koufakis, Hana Fakhoury, Kalliopi Kotsa
The teleological purpose of an ongoing pregnancy is to fulfill its fundamental role of a successful, uncomplicated delivery, in conjunction with an optimal intrauterine environment for the developing fetus. Vitamin D metabolism is adapted to meet both these demands during pregnancy; first by stimulation of calcium absorption for adequate intrauterine bone mineral accrual of the fetus, and second, by enhancing systemic and local maternal tolerance to paternal and fetal alloantigens. Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy...
2018: Frontiers in Endocrinology
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