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Vitamin D, diabetes

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https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#1
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27898216/characterization-of-prostacyclin-associated-leg-pain-in-patients-with-pulmonary-arterial-hypertension
#2
Gabriel L Pagani-Estévez, Keith M Swetz, Michael D McGoon, Robert P Frantz, Susan K Tointon, Ann M Karnyski, Louise A Durst, James C Watson
RATIONALE: Prostacyclin-associated leg pain is a potentially debilitating adverse effect of prostacyclin therapy for patients with pulmonary arterial hypertension (PAH). However, to our knowledge, this entity has not been systematically studied. OBJECTIVE: To characterize the clinical features and metabolic risk factors for prostacyclinassociated leg pain. METHODS: At one academic medical center we assembled and analyzed a case series of patients with PAH and prostacyclin-associated leg pain...
November 29, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27895928/assessing-the-population-impact-of-low-rates-of-vitamin-d-supplementation-on-type-1-diabetes-using-a-new-statistical-method
#3
Christos S Zipitis, Zulf M Mughal, Peter E Clayton
Vitamin D supplementation for all children <5 is recommended by the UK Department of Health for its skeletal effects. Vitamin D is also linked with a number of extra-skeletal effects; one of them being protection against type 1 diabetes. With a rapid increase in the incidence of type 1 diabetes and the associated costs, measures of curtailing the rapid increase of type 1 diabetes are needed. In this review, we look at type 1 diabetes using a statistical method (PIN-ER-t) and published data in an attempt to quantify the impact on the population of babies born in 2012 of increasing vitamin D supplementation rates...
November 2016: JRSM Open
https://www.readbyqxmd.com/read/27894216/bone-effects-of-canagliflozin-a-sodium-glucose-co-transporter-2-inhibitor-in-patients-with-type-2-diabetes-mellitus
#4
Thomas C Blevins, Azeez Farooki
Canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM), lowers blood glucose by inhibiting renal glucose reabsorption and increasing urinary glucose excretion. It has been reported that SGLT2 inhibitors may have potential adverse effects on bone, including increased fracture risk and decreased bone mineral density (BMD). Across clinical studies, canagliflozin was not associated with meaningful changes in serum or urine calcium, vitamin D, or parathyroid hormone...
November 28, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27891515/the-association-between-vdr-gene-polymorphisms-and-diabetic-retinopathy-susceptibility-a-systematic-review-and-meta-analysis
#5
Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic. Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27891186/relationship-between-vitamin-d-status-glycemic-control-and-cardiovascular-risk-factors-in-brazilians-with-type-2-diabetes-mellitus
#6
Maria Creusa Rolim, Bárbara Mendes Santos, Gildasio Conceição, Paulo Novis Rocha
OBJECTIVES: Determine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study with consecutive patients treated at a University Hospital's Endocrinology outpatient clinic located at 12°58'S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence)...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27887750/chronic-kidney-disease
#7
REVIEW
Angela C Webster, Evi V Nagler, Rachael L Morton, Philip Masson
The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m(2), or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also in many low-income countries. Incidence, prevalence, and progression of CKD also vary within countries by ethnicity and social determinants of health, possibly through epigenetic influence...
November 22, 2016: Lancet
https://www.readbyqxmd.com/read/27883024/lower-vitamin-d-metabolites-levels-were-associated-with-increased-coronary-artery-diseases-in-type-2-diabetes-patients-in-india
#8
Ramu Adela, Roshan M Borkar, Murali Mohan Bhandi, Gayatri Vishwakarma, P Naveen Chander Reddy, R Srinivas, Sanjay K Banerjee
The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n = 50), type 2 diabetes (T2DM, n = 71), coronary artery diseases (CAD, n = 28), T2DM_CAD (n = 38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#9
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27874274/differential-association-between-sarcopenia-and-metabolic-phenotype-in-korean-young-and-older-adults-with-and-without-obesity
#10
You-Cheol Hwang, In-Jin Cho, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
OBJECTIVE: To determine whether sarcopenia was associated with metabolic phenotype in subjects with and without obesity. METHODS: A total of 6,021 participants (2,592 men, 3,429 women) aged 30 to 93 years were assessed using data from the 2009 Korea National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass divided by weight (%) that is <1 SD below the sex-specific mean for young adults. Metabolically unhealthy was defined as ≥2 components of metabolic syndrome or the presence of hypertension, diabetes, or cardiovascular disease...
November 22, 2016: Obesity
https://www.readbyqxmd.com/read/27866309/osteoporosis-in-patients-with-diabetes-after-kidney-transplantation
#11
REVIEW
Elvira O Gosmanova, Aidar R Gosmanov
Preexisting diabetes increases risk of fractures after kidney transplantation (KT). However, little is known about mechanisms and prevention of increased fragility in these patients. Pathophysiology of osteoporosis after KT is complex and characterized by high prevalence of adynamic bone disease. Despite high prevalence of preexisting diabetes in KT recipients, diabetes patients were underrepresented in the studies that explored mechanisms and treatments of osteoporosis after KT. Therefore, caution should be exercised before considering conventional fracture prevention strategies in this unique group of patients...
November 19, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27865354/vitamin-d-supplementation-reduces-insulin-resistance-in-japanese-adults-a-secondary-analysis-of-a-double-blind-randomized-placebo-controlled-trial
#12
Xiaomin Sun, Zhen-Bo Cao, Kumpei Tanisawa, Tomoko Ito, Satomi Oshima, Mitsuru Higuchi
Higher circulating 25-hydroxyvitamin D (25[OH]D) concentration has been linked to a lower prevalence of insulin resistance and type 2 diabetes mellitus. However, randomized controlled trials have not clarified the effect of vitamin D supplementation on insulin resistance in healthy adults. The objective of this study was to assess the effect of vitamin D supplementation for 1 year on insulin resistance; the study was a secondary analysis of a clinical trial. We hypothesized that increased 25(OH)D concentration after vitamin D supplementation for 1 year would significantly improve insulin resistance...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27864670/relationship-between-vitamin-d-deficiency-and-the-components-of-metabolic-syndrome-in-patients-with-morbid-obesity-before-and-1%C3%A2-year-after-laparoscopic-roux-en-y-gastric-bypass-or-sleeve-gastrectomy
#13
Ana Obispo Entrenas, David Legupin Tubio, Fabiola Lucena Navarro, Francisco Martin Carvajal, Norberto Gandara Adan, Maximino Redondo Bautista, Jimena Abiles Osinaga
BACKGROUND: Vitamin D deficiency (VDD) is associated with obesity and metabolic syndrome (MS). After bariatric surgery (BS), high rates of VDD often persist and some patients are refractory to the resolution of comorbidities. The aim of the present study is to analyse the relationship between the levels of vitamin D and the persistence of MS components at 12 months after BS, according to the surgical technique used. METHODS: We performed a retrospective study of 46 patients undergoing BS: 23 underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP) and 23 laparoscopic sleeve gastrectomy (LSG)...
November 18, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27862247/association-between-serum-25-oh-d3-and-cardiovascular-morbidity-and-mortality-in-people-with-type%C3%A2-2-diabetes-a-community-based-cohort-study
#14
M Samefors, R Scragg, T Länne, F H Nyström, C J Östgren
AIM: We aimed to explore the association between vitamin D and cardiovascular morbidity and mortality in people with Type 2 diabetes recruited from a community-based study because there is limited and inconsistent research of this group. METHODS: A prospective community-based cohort study among people aged 55-66 years with Type 2 diabetes as part of The Cardiovascular Risk in Type 2 Diabetes - A Prospective Study in Primary Care (CARDIPP). We analysed serum 25-hydroxyvitamin D3 [25(OH)D3 ] at baseline...
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27859562/vitamin%C3%A2-c-deficiency-and-diabetes-mellitus-easily-missed
#15
D J Christie-David, J E Gunton
Scurvy and vitamin C deficiency are usually considered to be of only historical interest. Interestingly, most animals can synthesize vitamin C, but not humans, higher primates, guinea-pigs and some bats. Deficiency results in the defective formation of collagen and connective tissues; symptoms of deficiency may include bruising, bleeding gums, petechiae, arthralgia and impaired wound healing [1,2]. This article is protected by copyright. All rights reserved.
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27858878/association-between-pulmonary-fibrosis-and-osteoporosis-in-the-elderly-people-a-case-control-study
#16
Zhong Xie, Yanhong He, Yongqiang Sun, Zhanzhan Lin, Mingzhi Yang, Qian Liu, Sihai Liu
In this case-control study, we evaluated the association between osteoporosis and pulmonary fibrosis in the elderly. Participants were divided into a test group and a control group depending on bone mineral density and grid pattern changes of pulmonary fibrosis. We measured general conditions, related risk factors, serum biochemical index, grid pattern changes of double lungs, pulmonary function, arterial oxygen pressure (PO2), and bone mineral density of participates, and investigated the data through statistical analysis on SPSS 17...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855294/evidence-for-the-vitamin-d-hypothesis-the-nhanes-iii-extended-mortality-follow-up
#17
Ahmad H Daraghmeh, Monica L Bertoia, Mazen O Al-Qadi, Abdulrahman M Abdulbaki, Mary B Roberts, Charles B Eaton
BACKGROUND AND AIMS: Emerging evidence suggests that low levels of vitamin D may be an important risk factor for multiple chronic diseases and mortality, but the evidence is mixed. Vitamin D levels are associated with sun exposure, diet, and metabolic status. One potential explanation for the lack of consistent findings amongst various studies is that low vitamin levels may be associated with poor diets or other risk factors that we were not adequately controlled for in different analyses...
April 9, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27849379/lower-serum-25-hydroxyvitamin-d-is-associated-with-obesity-but-not-common-chronic-conditions-an-observational-study-of-african-american-and-caucasian-male-veterans
#18
Jacqueline L Cartier, Subhash C Kukreja, Elena Barengolts
Objective The study examined whether vitamin D insufficiency is a predictor of prevalent and/or incident common chronic conditions in African American men (AAM) and Caucasian men (CAM). Methods 1,017 men were recruited at an urban VA medical center and followed prospectively for a mean of 5.4 years. Prevalent and incident chronic conditions evaluated were: obesity, type 2 diabetes (T2D), cancer, depression, dementia, and cardiovascular disease (CVD, including coronary artery disease [CAD], cerebrovascular accident [CVA], and congestive heart failure [CHF])...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27843556/seasonality-of-gestational-diabetes-mellitus-a-south-australian-population-study
#19
Petra E Verburg, Graeme Tucker, Wendy Scheil, Jan Jaap H M Erwich, Gus A Dekker, Claire T Roberts
OBJECTIVE: To investigate whether there is a seasonal variation in the incidence of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: This retrospective cohort study of 60 306 eligible South Australian live-born singletons during 2007-2011 recorded in the South Australian Perinatal Statistics Collection (SAPSC) examined the incidence of GDM in relation to estimated date of conception (eDoC). Fourier series analysis was used to model seasonal trends...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27843555/evaluation-of-vitamin-d-relationship-with-type-2-diabetes-and-systolic-blood-pressure
#20
Shivananda Bijoor Nayak, Terry Gavaskar Ramnanansingh
OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. RESEARCH DESIGN AND METHODS: This was a case-controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed. Plasma calcifediol (25(OH)D) concentrations were used as a measurement for vitamin D levels and were determined by ELISA...
2016: BMJ Open Diabetes Research & Care
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