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Vitamin D, diabetes

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https://www.readbyqxmd.com/read/28734987/bioavailable-and-free-25-hydroxyvitamin-d-and-vitamin-d-binding-protein-in-polycystic-ovary-syndrome-relationships-with-obesity-and-insulin-resistance
#1
Negar Naderpoor, Soulmaz Shorakae, Sally K Abell, Aya Mousa, Anju E Joham, Lisa J Moran, Nigel K Stepto, Poli Mara Spritzer, Helena J Teede, Barbora de Courten
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28728874/profile-of-chronic-kidney-disease-related-mineral-bone-disorders-in-newly-diagnosed-advanced-predialysis-diabetic-kidney-disease-patients-a-hospital-based-cross-sectional-study
#2
S Ray, A M Beatrice, A Ghosh, S Pramanik, R Bhattacharjee, S Ghosh, A Raychaudhury, S Mukhopadhyay, S Chowdhury
AIM: Chronic kidney disease related-mineral bone disorder (CKD-MBD) has been poorly studied in pre-dialysis Indian CKD population. There are limited data on the pattern of these disturbances in diabetic CKD patients. Therefore, a study was conducted to find out the profile of mineral bone disorders in T2DM patients with pre-dialysis CKD. METHODS: In this cross-sectional design, diabetic patients with newly-diagnosed stage 4 and 5 CKD were evaluated. Serum levels of calcium, phosphorus, intact parathyroid hormone (iPTH), 25 hydroxy vitamin D and total alkaline phosphatase (ALP) were measured in all patients...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28727342/-obesity-fat-and-bones-friends-or-foes
#3
Emmanuel Biver
Low fat mass is associated with an increased risk of fracture because of low bone mineral density (BMD) and altered bone micro-architecture. Conversely, overweight and obese patients also have an increased risk of fracture, particularly of the humerus and ankle, despite greater BMD. Visceral abdominal fat, which is the most metabolically active, may be associated with poorer quality of bone tissue properties, as suggested in diabetes. Other factors may contribute to higher fracture risk in overweight patients, notably higher frequency of falls and lower bioavailability of vitamin D stoked in fat...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28721140/serum-adipokines-and-vitamin-d-levels-in-patients-with-type-1-diabetes-mellitus
#4
Mohamed M Ismail, Tamer A Abdel Hamid, Alshaymaa A Ibrahim, Huda Marzouk
INTRODUCTION: Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes. MATERIAL AND METHODS: Fifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28717531/the-role-of-vitamin-d-supplementation-on-erectile-function
#5
REVIEW
Raidh A Talib, Kareim Khalafalla, Önder Cangüven
In the last few years growing evidence highlighted vitamin D (VD) deficiency is one of the several dynamics that associates with increased atherosclerotic cardiovascular (ASCV) diseases. ASCV diseases and erectile dysfunction (ED) share common risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle. The aim of this review was to summarize current progress in VD research by focusing effect of low VD level on different body systems and erectile function. Here we examine research linking VD deficiency and ED and discuss how VD influences ED and its classic risk factors that also associate to increased ED risk...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28714882/vitamin-d-supplementation-enhances-c18-dihydro-ceramide-levels-in-type-2-diabetes-patients
#6
Alexander Koch, Georgios Grammatikos, Sandra Trautmann, Yannick Schreiber, Dominique Thomas, Franziska Bruns, Josef Pfeilschifter, Klaus Badenhoop, Marissa Penna-Martinez
Sphingolipids are characterized by a broad range of bioactive properties. Particularly, the development of insulin resistance, a major pathophysiological hallmark of Type 2 Diabetes mellitus (T2D), has been linked to ceramide signaling. Since vitamin D supplementation may slow down T2D progression by improving glucose concentrations and insulin sensitivity, we investigated whether vitamin D supplementation impacts on plasma sphingolipid levels in T2D patients. Thus, plasma samples of 59 patients with non-insulin-requiring T2D from a placebo-controlled, randomized, and double-blind study were retrospectively analyzed...
July 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28710799/high-glucose-induces-o-glcnac-glycosylation-of-the-vitamin-d-receptor-vdr-in-thp1-cells-and-in-human-macrophages-derived-from-monocytes
#7
Fernando Hernandez-Sánchez, Silvia Guzmán-Beltrán, María Teresa Herrera, Yolanda Gonzalez, Manuel Salgado, Guadalupe Fabian, Martha Torres
Chronic hyperglycemia increases the carbon flux through the hexosamine pathway, allowing the accumulation of UDP-GlcNAc. UDP-GlcNAc is the sugar donor for the enzyme-mediated protein glycosylation event known as OGlcNAcylation. This posttranslational modification targets several transcription factors implicated in glucose toxicity, insulin resistance, and diabetes. Vitamin D plays an important role in glucose homeostasis and insulin secretion through transcriptional mechanisms mediated by its receptor (VDR)...
July 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28704095/sarcopenia-an-endocrine-disorder
#8
Alexis McKee, John E Morley, Alvin M Matsumoto, Aaron Vinik
Sarcopenia is defined as low muscle function (walking speed or grip strength) in the presence of low muscle mass. A simple screening test - the SARC-F - is available to identify persons with sarcopenia. The major endocrine causes of sarcopenia are diabetes mellitus and male hypogonadism. Other causes are decreased physical activity, loss of motor neuron units, weight loss, inflammatory cytokines, reduced blood flow to muscles, very low 25(OH) vitamin D levels and decreased growth hormone and IGF-1. Treatment for sarcopenia includes resistance and aerobic exercise, leucine enriched essential amino acids, and vitamin D...
July 13, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28703918/association-between-the-vitamin-d-receptor-gene-polymorphisms-and-diabetic-nephropathy-risk-a-meta-analysis
#9
Fang Yin, Jing Liu, Ming-Xiu Fan, Xiao-Li Zhou, Xiao-Ling Zhang
AIMS: Diabetic nephropathy (DN) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this study was to estimate the effect between Apa I, Bsm I, Fok I and Taq I polymorphisms of the vitamin D receptor (VDR) gene and DN susceptibility. METHODS: Eligible case-control studies published updated to March 2017 were searched. The odds ratio (OR) and 95% confident intervals (CI) were employed to calculate the strength of effect...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28702810/epidemiology-of-gestational-diabetes-mellitus-according-to-iadpsg-who-2013-criteria-among-obese-pregnant-women-in-europe
#10
Aoife M Egan, Akke Vellinga, Jürgen Harreiter, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M Adelantado, Roland Devlieger, Andre Van Assche, Sander Galjaard, Peter Damm, Elisabeth R Mathiesen, Dorte M Jensen, Liselotte Andersen, Annuziata Lapolla, Maria G Dalfrà, Alessandra Bertolotto, Urszula Mantaj, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Judith G M Jelsma, Frank J Snoek, Christof Worda, Dagmar Bancher-Todesca, Mireille N M van Poppel, Alexandra Kautzky-Willer, Fidelma P Dunne
AIMS/HYPOTHESIS: Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for GDM development and calculate the prevalence of GDM in a cohort of women with BMI ≥29 kg/m(2) across 11 centres in Europe using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG)/WHO 2013 diagnostic criteria...
July 12, 2017: Diabetologia
https://www.readbyqxmd.com/read/28698808/vitamins-k1-and-k2-the-emerging-group-of-vitamins-required-for-human-health
#11
REVIEW
Gerry Kurt Schwalfenberg
OBJECTIVE: To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. QUALITY OF EVIDENCE: PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference proceedings and health conditions listed above. Level I and II evidence supports the use of vitamins K1 and K2 in osteoporosis and Level II evidence supports vitamin K2 in prevention of coronary calcification and cardiovascular disease...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28691410/the-risk-of-plasma-vitamin-a-c-e-and-d-deficiency-in-patients-with-metabolic-syndrome-a-case-control-study
#12
Małgorzata Maria Godala, Izabela Materek-Kuśmierkiewicz, Dariusz Moczulski, Maciej Rutkowski, Franciszek Szatko, Ewelina Gaszyńska, Sławomir Tokarski, Jan Kowalski
BACKGROUND: The increasing incidence of metabolic diseases such as obesity or diabetes made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species , which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among non-enzymatic mechanisms counteracting this phenomenon. Vitamin D deficiency is also associated with cardiovascular diseases. OBJECTIVES: The aim of the study was to assess the risk of vitamin A, C, E and D deficit in plasma of metabolic syndrome (MS) patients...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28686746/obstructive-sleep-apnea-and-objective-short-sleep-duration-are-independently-associated-with-the-risk-of-serum-vitamin-d-deficiency
#13
Ronaldo D Piovezan, Camila Hirotsu, Marcia C Feres, Fatima D Cintra, Monica L Andersen, Sergio Tufik, Dalva Poyares
BACKGROUND: Studies demonstrate an association between vitamin D (25(OH)D) deficiency and sleep disturbances, such as obstructive sleep apnea (OSA) and short sleep duration. However, to date, no studies have concurrently and objectively evaluated the effect of these factors on 25(OH)D. OBJECTIVES: To evaluate whether OSA and objective short sleep duration are independently associated with reduced 25(OH)D in an adult population sample. METHODS: A cross-sectional study included 657 individuals from the city of Sao Paulo, Brazil, as part of the ERA project...
2017: PloS One
https://www.readbyqxmd.com/read/28686645/non-skeletal-health-effects-of-vitamin-d-supplementation-a-systematic-review-on-findings-from-meta-analyses-summarizing-trial-data
#14
Lars Rejnmark, Lise Sofie Bislev, Kevin D Cashman, Gudny Eiríksdottir, Martin Gaksch, Martin Grübler, Guri Grimnes, Vilmundur Gudnason, Paul Lips, Stefan Pilz, Natasja M van Schoor, Mairead Kiely, Rolf Jorde
BACKGROUND: A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin D (25OHD) levels on non-skeletal outcomes. We performed a systematic quantitative review on characteristics of randomized clinical trials (RCTs) included in meta-analyses (MAs) on non-skeletal effects of vitamin D supplementation. METHODS AND FINDINGS: We identified systematic reviews (SR) reporting summary data in terms of MAs of RCTs on selected non-skeletal outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28677090/klotho-levels-association-with-insulin-resistance-and-albumin-to-creatinine-ratio-in-type-2-diabetic-patients
#15
Ana Paula Silva, Filipa Mendes, Luísa Pereira, André Fragoso, Rui Baptista Gonçalves, Nélio Santos, Fátima Rato, Pedro Leão Neves
PURPOSE: The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD. METHODS: We conducted an observational, cross-sectional study in our outpatient diabetic nephropathy clinic from 2014 to 2016, enrolling a total of 107 type 2 diabetic patients with stage 2-3 CKD, with a mean age of 59 years. Several clinical and laboratorial parameters were evaluated, including those related to mineral and carbohydrate metabolism...
July 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28674684/effect-of-fetal-sex-on-maternal-and-obstetric-outcomes
#16
REVIEW
Mohammed Al-Qaraghouli, Yu Ming Victor Fang
Fetal sex plays an important role in modifying the course and complications related to pregnancy and may also have an impact on maternal health and well-being both during and after pregnancy. The goal of this article is to review and summarize the findings from published research on physiologic and pathologic changes that may be affected by fetal sex and the effect of these changes on the maternal and obstetrical outcomes. This will help create awareness that fetal sex is not just a random chance event but an interactive process between the mother, the placenta, and the fetus...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28670540/effect-of-vitamin-d-supplementation-on-vascular-functions-and-oxidative-stress-in-type-2-diabetic-patients-with-vitamin-d-deficiency
#17
Nishanthi Anandabaskar, Sandhiya Selvarajan, Steven Aibor Dkhar, Sadish Kumar Kamalanathan, Kadhiravan Tamilarasu, Zachariah Bobby
BACKGROUND: Vitamin D levels are reported to have an inverse liaison with the risk of cardiovascular diseases. Hence, we aimed to evaluate the effect of Vitamin D supplementation on changes in vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency. SUBJECTS AND METHODS: One hundred and three patients with type 2 diabetes attending endocrinology outpatients department in a tertiary care hospital were screened for Vitamin D deficiency...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670536/osteoporosis-in-otherwise-healthy-patients-with-type-2-diabetes-a-prospective-gender-based-comparative-study
#18
Balram Sharma, Hema Singh, Praveen Chodhary, Sanjay Saran, Sandeep Kumar Mathur
BACKGROUND AND OBJECTIVE: Type 2 diabetes mellitus (T2DM) may affect bone loss differentially in adult males and postmenopausal females. We evaluated the prevalence of osteoporosis in otherwise healthy adults with T2DM. MATERIALS AND METHODS: In a cross-sectional study, adults with T2DM, aged 50 years and above, were evaluated for bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) scan at spine and hip. T-score of ≤-2.5 was defined as osteoporosis and score -2...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28670530/myopathy-in-patients-taking-atorvastatin-a-pilot-study
#19
K Manoj, N Jain, S V Madhu
AIM: This study aims to investigate the prevalence and risk factors of statin-induced myopathy. SUBJECTS AND METHODS: A total of 200 patients aged ≥ 40 years and taking atorvastatin 10 mg/day or more for at least 2 weeks were recruited in the study. A detailed history of participants and anthropometry of study participants was recorded, and features of myopathy were explained. Biochemical investigations along with thyroid stimulating hormone (TSH) and Vitamin D were done in all patients...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28664450/factors-that-affect-outcome-following-total-joint-arthroplasty-a-review-of-the-recent-literature
#20
REVIEW
Forrest H Schwartz, Jeffrey Lange
PURPOSE OF REVIEW: It is well established that certain patient-specific risk factors affect outcomes following total joint arthroplasty. The goal of this paper is to summarize the latest data on several variables that have been investigated in the last 3 years and to characterize the effects these factors have on the success of hip and knee replacement. RECENT FINDINGS: Preoperative diagnoses of depression and anxiety, liver disease, hypoalbuminemia, vitamin D deficiency, and diabetes mellitus are associated with increased risk of postoperative complications and can lead to worse outcomes after joint replacement surgery...
June 29, 2017: Current Reviews in Musculoskeletal Medicine
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