keyword
https://read.qxmd.com/read/38482171/sodium-butyrate-impedes-the-lymphoma-caused-by-marek-s-disease-virus-via-regulating-the-mitochondrial-apoptosis-pathway
#21
JOURNAL ARTICLE
Qiaoer Lin, Jun Zhou, Fan Yang, Congsen Zheng, Meiting Chen, Chuanzhe Chang, Shikai Cai, Feng Wen, Nina Wang, Yanfeng Chen, Limei Qin
Sodium butyrate (NaB) has garnered attention in recent years for its ability to impede the malignant progression of tumors. In order to explore the potential inhibitory effects of NaB on the replication of Marek's disease virus (MDV) and subsequent lymphoma formation, newly hatched chickens were infected with the vvMDV Md5 strain and administered NaB prior to (prevention group) or following (treatment group) Md5 inoculation. The results revealed that NaB played a pivotal role in diminishing both the incidence and fatality rates in chickens afflicted with Md5 infection...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38478874/environmentally-relevant-concentrations-of-tetrabromobisphenol-a-exposure-impends-neurovascular-formation-through-perturbing-mitochondrial-metabolism-in-zebrafish-embryos-and-human-primary-endothelial-cells
#22
JOURNAL ARTICLE
Xiangyu Zeng, Shengtao Ma, Yijun Luo, Yangjian Zhang, Qi Wang, Zhuyi Zhang, Weijian Ke, Ya Ma, Haichen Hu, Thomas Hartung, Yanhong Wei, Xiali Zhong
Tetrabromobisphenol A (TBBPA), the most extensively utilized brominated flame retardant, has raised growing concerns regarding its environmental and health risks. Neurovascular formation is essential for metabolically supporting neuronal networks. However, previous studies primarily concerned the neuronal injuries of TBBPA, its impact on the neurovascularture, and molecular mechanism, which are yet to be elucidated. In this study, 5, 30, 100, 300 μg/L of TBBPA were administered to Tg (fli1a: eGFP) zebrafish larvae at 2-72 h postfertilization (hpf)...
March 13, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38478101/the-janus-faced-functions-of-apolipoproteins-l-in-membrane-dynamics
#23
JOURNAL ARTICLE
Etienne Pays
The functions of human Apolipoproteins L (APOLs) are poorly understood, but involve diverse activities like lysis of bloodstream trypanosomes and intracellular bacteria, modulation of viral infection and induction of apoptosis, autophagy, and chronic kidney disease. Based on recent work, I propose that the basic function of APOLs is the control of membrane dynamics, at least in the Golgi and mitochondrion. Together with neuronal calcium sensor-1 (NCS1) and calneuron-1 (CALN1), APOL3 controls the activity of phosphatidylinositol-4-kinase-IIIB (PI4KB), involved in both Golgi and mitochondrion membrane fission...
March 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38477411/nanoparticles-synergize-ferroptosis-and-cuproptosis-to-potentiate-cancer-immunotherapy
#24
JOURNAL ARTICLE
Youyou Li, Jing Liu, Yimei Chen, Ralph R Weichselbaum, Wenbin Lin
The recent discovery of copper-mediated and mitochondrion-dependent cuproptosis has aroused strong interest in harnessing this novel mechanism of cell death for cancer therapy. Here the design of a core-shell nanoparticle, CuP/Er, for the co-delivery of copper (Cu) and erastin (Er) to cancer cells for synergistic cuproptosis and ferroptosis is reported. The anti-Warburg effect of Er sensitizes tumor cells to Cu-mediated cuproptosis, leading to irreparable mitochondrial damage by depleting glutathione and enhancing lipid peroxidation...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38476836/the-second-complete-mitochondrial-genome-of-capillidium-rhysosporum-within-the-family-capillidiaceae-entomophthorales
#25
JOURNAL ARTICLE
Hanwen Lu, Yong Nie, Bo Huang
The complete mitochondrial genome of the entomophthoroid fungus Capillidium rhysosporum (strain no.: ATCC 12588) was sequenced using next-generation sequencing technology. The assembled circular genome has a length of 46,756 base pairs with a GC content of 27.06%. Gene prediction identified 15 core protein-coding genes (PCGs), two rRNA genes, and 27 tRNA genes. Phylogenetic analysis confirmed that C. rhysosporum belongs to the Zoopagomycota clade and is closely related to C. heterosporum . This study presents the second complete mitochondrial genome within the family Capillidiaceae, contributing to the mitochondrial DNA database of entomophthoroid fungi...
2024: Mitochondrial DNA. Part B. Resources
https://read.qxmd.com/read/38474307/proteomic-analysis-highlights-the-impact-of-the-sphingolipid-metabolizing-enzyme-%C3%AE-galactosylceramidase-on-mitochondrial-plasticity-in-human-melanoma
#26
JOURNAL ARTICLE
Davide Capoferri, Luca Mignani, Marcello Manfredi, Marco Presta
Mitochondrial plasticity, marked by a dynamism between glycolysis and oxidative phosphorylation due to adaptation to genetic and microenvironmental alterations, represents a characteristic feature of melanoma progression. Sphingolipids play a significant role in various aspects of cancer cell biology, including metabolic reprogramming. Previous observations have shown that the lysosomal sphingolipid-metabolizing enzyme β-galactosylceramidase (GALC) exerts pro-oncogenic functions in melanoma. Here, mining the cBioPortal for a Cancer Genomics data base identified the top 200 nuclear-encoded genes whose expression is negatively correlated with GALC expression in human melanoma...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472304/the-use-of-nadh-anisotropy-to-investigate-mitochondrial-cristae-alignment
#27
JOURNAL ARTICLE
Holly E Smith, Alasdair M Mackenzie, Chloe Seddon, Rhys Mould, Ifi Kalampouka, Partha Malakar, Sarah R Needham, Konstantinos Beis, Jimmy D Bell, Alistair Nunn, Stanley W Botchway
Life may be expressed as the flow of electrons, protons, and other ions, resulting in large potential difference. It is also highly photo-sensitive, as a large proportion of the redox capable molecules it relies on are chromophoric. It is thus suggestive that a key organelle in eukaryotes, the mitochondrion, constantly adapt their morphology as part of the homeostatic process. Studying unstained in vivo nano-scale structure in live cells is technically very challenging. One option is to study a central electron carrier in metabolism, reduced nicotinamide adenine dinucleotide (NADH), which is fluorescent and mostly located within mitochondria...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38471579/genetic-heterogeneity-and-respiratory-chain-enzyme-analysis-in-pediatric-indian-patients-with-mitochondrial-disorder-report-of-novel-variants-in-polg1-gene-and-their-functional-implication-using-molecular-dynamic-simulation
#28
JOURNAL ARTICLE
Debolina Saha, Sonam Kothari, Shilpa Duttaprasanna Kulkarni, Menaka Thambiraja, Ragothaman M Yennamalli, Dhanjit K Das
Mitochondrial disorders are a heterogeneous group of disorders caused by mutations in the mitochondrial DNA or in nuclear genes encoding the mitochondrial proteins and subunits. Polymerase Gamma (POLG) is a nuclear gene and mutation in the POLG gene are one of the major causes of inherited mitochondrial disorders. In this study, 15 pediatric patients, with a wide spectrum of clinical phenotypes were screened using blood samples (n=15) and muscle samples (n=4). Respiratory chain enzyme analysis in the muscle samples revealed multi-complex deficiencies with Complex I deficiency present in (1/4) patients, Complex II (2/4), Complex III (3/4) and Complex IV (2/4) patients...
March 10, 2024: Mitochondrion
https://read.qxmd.com/read/38467292/effects-of-chronic-hydrogen-peroxide-exposure-on-mitochondrial-oxidative-stress-genes-ros-production-and-lipid-peroxidation-in-hl60-cells
#29
JOURNAL ARTICLE
M Montserrat-Mesquida, M D Ferrer, A Pons, A Sureda, X Capóa
Hydrogen peroxide (H2 O2 ) is a reactive species that is also involved in the redox regulation of cells because of it is relative stability. In numerous pathological situations, a chronic increase in the production of reactive species is observed, which is related to oxidative stress and cellular damage. This study aimed to evaluate the effects of long-term exposure to different H2 O2 concentrations on oxidative stress biomarkers and mitochondrial dynamics in HL60 cells. HL60 cells were treated with a sustained production (0...
March 9, 2024: Mitochondrion
https://read.qxmd.com/read/38462159/ancient-mitogenomes-suggest-complex-maternal-history-of-one-of-the-oldest-settlements-of-western-india
#30
JOURNAL ARTICLE
Bhavna Ahlawat, Lomous Kumar, Abhijit Ambekar, Jagmahender Singh Sehrawat, Yadubir Singh Rawat, Niraj Rai
The ancient township of Vadnagar tells a story of a long chain of cultural diversity and exchange. Vadnagar has been continuously habituated and shows a presence of rich cultural amalgamation and continuous momentary sequences between the 2th century BCE and present-day. Seven cultural periods developed a complex and enriched settlement at Vadnagar in spatio-temporality. Although archaeological studies done on this oldest settlement suggested a rich cultural heritage, the genetic studies to pinpoint the genetic ancestry was lacking till date...
March 8, 2024: Mitochondrion
https://read.qxmd.com/read/38462158/involvement-of-mitochondria-in-alzheimer-s-disease-pathogenesis-and-their-potential-as-targets-for-phytotherapeutics
#31
REVIEW
Swathi Maruthiyodan, Kamalesh Dattaram Mumbrekar, Kanive Parashiva Guruprasad
Alzheimer's disease (AD) is the leading cause of dementia around the globe. The disease's genesis is multifaceted, and its pathophysiology is complicated. Malfunction of mitochondria has been regarded as one of the intracellular events that are substantially damaged in the onset of AD and are likely a common trait of other neurodegenerative illnesses. Several mitochondrial characteristics begin to diminish with age, eventually reaching a state of significant functional failure concurrent with the beginning of neurodegenerative diseases, however, the exact timing of these processes is unknown...
March 8, 2024: Mitochondrion
https://read.qxmd.com/read/38452217/blastocrithidia-nonstop-mitochondrial-genome-and-its-expression-are-remarkably-insulated-from-nuclear-codon-reassignment
#32
JOURNAL ARTICLE
Dmitry A Afonin, Evgeny S Gerasimov, Ingrid Škodová-Sveráková, Kristína Záhonová, Ondřej Gahura, Amanda T S Albanaz, Eva Myšková, Anastassia Bykova, Zdeněk Paris, Julius Lukeš, Fred R Opperdoes, Anton Horváth, Sara L Zimmer, Vyacheslav Yurchenko
The canonical stop codons of the nuclear genome of the trypanosomatid Blastocrithidia nonstop are recoded. Here, we investigated the effect of this recoding on the mitochondrial genome and gene expression. Trypanosomatids possess a single mitochondrion and protein-coding transcripts of this genome require RNA editing in order to generate open reading frames of many transcripts encoded as 'cryptogenes'. Small RNAs that can number in the hundreds direct editing and produce a mitochondrial transcriptome of unusual complexity...
March 7, 2024: Nucleic Acids Research
https://read.qxmd.com/read/38451019/a-novel-mutation-in-mitochondrial-cytochrome-b-conferring-resistance-to-bifenazate-in-two-spotted-spider-mite-tetranychus-urticae-koch-acarina-tetranychidae
#33
JOURNAL ARTICLE
Yizhou Chen, Duong T Nguyen, David Wheeler, Grant A Herron
BACKGROUND: The two-spotted spider mite Tetranychus urticae causes significant damage to ornamental, cotton, sugarcane, and horticultural crops in Australia. It has a long history of developing resistance to many acaricides including bifenazate. A mutation in the conserved cd1- and ef-helices of the Qo pocket of cytochrome b is recognized as the primary mechanism of bifenazate resistance. To investigate the resistance mechanisms against bifenazate in Australian two-spotted spider mite we sequenced the complete mitochondrion genome of five mite strains including a susceptible and bifenazate-resistant strain...
March 7, 2024: Pest Management Science
https://read.qxmd.com/read/38447826/fibronectin-1-supports-oocyte-in-vitro-maturation-in-pigs
#34
JOURNAL ARTICLE
Mingju Sun, Xiangyu Wang, Fanglong Bi, Hongxiao Xiang, Ning Wang, Wenju Gao, Yixuan Liu, Zizhen Lv, Youwei Li, Yanjun Huan
Oocyte in vitro maturation (IVM) based on the follicular fluid (FF) environment can exploit untapped resources, however, what FF factors regulate oocyte maturation remains unclear. This work demonstrated that serum and FF significantly promoted oocyte polar body extrusion (PBE) and subsequent embryo development, and FF was especially effective. Fibronectin 1 (FN1) was predicted as one potential candidate to regulate oocyte maturation by proteomics. FN1 transcription obviously decreased, and the protein expression significantly increased and migrated to plasma membrane or even outside during oocyte IVM...
March 4, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38447112/recent-advances-in-detection-of-hydroxyl-radical-by-responsive-fluorescence-nanoprobes
#35
JOURNAL ARTICLE
Mazen Alanazi, Jiaxi Yong, Miaomiao Wu, Zexi Zhang, Dihua Tian, Run Zhang
Hydroxyl radical (•OH), a highly reactive oxygen species (ROS), is assumed as one of the most aggressive free radicals. This radical has a detrimental impact on cells as it can react with different biological substrates leading to pathophysiological disorders, including inflammation, mitochondrion dysfunction, and cancer. Quantification of this free radical in-situ plays critical roles in early diagnosis and treatment monitoring of various disorders, like macrophage polarization and tumor cell development...
March 6, 2024: Chemistry, An Asian Journal
https://read.qxmd.com/read/38447055/distribution-and-functional-analysis-of-isocitrate-dehydrogenases-across-kinetoplastids
#36
JOURNAL ARTICLE
Ľubomíra Chmelová, Kristína Záhonová, Amanda T S Albanaz, Liudmyla Hrebenyk, Anton Horváth, Vyacheslav Yurchenko, Ingrid Škodová-Sveráková
Isocitrate dehydrogenase (IDH) is an enzyme converting isocitrate to α-ketoglutarate in the canonical tricarboxylic acid (TCA) cycle. There are three different types of IDH documented in eukaryotes. Our study points out the complex evolutionary history of IDHs across kinetoplastids, where the common ancestor of Trypanosomatidae and Bodonidae was equipped with two isoforms of the IDH enzyme: the NADP+-dependent IDH1 with possibly dual localization in the cytosol and mitochondrion and NADP+-dependent mitochondrial IDH2...
March 6, 2024: Genome Biology and Evolution
https://read.qxmd.com/read/38437941/identification-of-a-novel-mt-nd3-variant-and-restoring-mitochondrial-function-by-allotopic-expression-of-mt-nd3-gene
#37
JOURNAL ARTICLE
Nurun Nahar Borna, Yoshihito Kishita, Masaru Shimura, Kei Murayama, Akira Ohtake, Yasushi Okazaki
Mitochondrial diseases are caused by nuclear, or mitochondrial DNA (mtDNA) variants and related co-factors. Here, we report a novel m.10197G > C variant in MT-ND3 in a patient, and two other patients with m.10191 T > C. MT-ND3 variants are known to cause Leigh syndrome or mitochondrial complex I deficiency. We performed the functional analyses of the novel m.10197G > C variant that significantly lowered MT-ND3 protein levels, causing complex I assembly and activity deficiency, and reduction of ATP synthesis...
March 2, 2024: Mitochondrion
https://read.qxmd.com/read/38437643/melatonin-derived-carbon-dots-with-free-radical-scavenging-property-for-effective-periodontitis-treatment-via-the-nrf2-ho-1-pathway
#38
JOURNAL ARTICLE
Xirui Xin, Junjun Liu, Xinchan Liu, Yu Xin, Yubo Hou, Xingchen Xiang, Yu Deng, Bai Yang, Weixian Yu
Periodontitis is a chronic inflammatory disease closely associated with reactive oxygen species (ROS) involvement. Eliminating ROS to control the periodontal microenvironment and alleviate the inflammatory response could potentially serve as an efficacious therapy for periodontitis. Melatonin (MT), renowned for its potent antioxidant and anti-inflammatory characteristics, is frequently employed as an ROS scavenger in inflammatory diseases. However, the therapeutic efficacy of MT remains unsatisfactory due to the low water solubility and poor bioavailability...
March 4, 2024: ACS Nano
https://read.qxmd.com/read/38437062/hepatocellular-carcinoma-cells-downregulate-nadh-ubiquinone-oxidoreductase-subunit-b3-to-maintain-reactive-oxygen-species-homeostasis
#39
JOURNAL ARTICLE
Zhendong Zhang, Qianwei Zhao, Zexuan Wang, Fang Xu, Yixian Liu, Yaoyu Guo, Chenglong Li, Ting Liu, Ying Zhao, Xiaolei Tang, Jintao Zhang
BACKGROUND: HCC is a leading cause of cancer-related death. The role of reactive oxygen species (ROS) in HCC remains elusive. Since a primary ROS source is the mitochondrial electron transport chain complex Ι and the NADH:ubiquinone Oxidoreductase Subunit B3 (NDUFB3), a complex I subunit, is critical for complex I assembly and regulates the associated ROS production, we hypothesize that some HCCs progress by hijacking NDUFB3 to maintain ROS homeostasis. METHODS: NDUFB3 in human HCC lines was either knocked down or overexpressed...
March 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38432451/oxphos-targeted-nanoparticles-for-boosting-photodynamic-therapy-against-hypoxia-tumor
#40
JOURNAL ARTICLE
Yujuan Gao, Yunhao Li, Zian Pan, Chenlu Xu, Xiaoyu Zhang, Mingjun Li, Weifeng Wang, Fan Jia, Yan Wu
Hypoxia as an inherent feature in tumors is firmly associated with unsatisfactory clinical outcomes of photodynamic therapy (PDT) since the lack of oxygen leads to ineffective reactive oxygen species (ROS) productivity for tumor eradication. In this study, an oxidative phosphorylation (OXPHOS) targeting nanoplatform was fabricated to alleviate hypoxia and enhance the performance of PDT by encapsulating IR780 and OXPHOS inhibitor atovaquone (ATO) in triphenylphosphine (TPP) modified poly(ethylene glycol) methyl ether-block-poly(L-lactide-co-glycolide) (mPEG-PLGA) nanocarriers (TNPs/IA)...
March 1, 2024: International Journal of Pharmaceutics
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