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https://www.readbyqxmd.com/read/29785072/insights-from-the-molecular-modelling-and-docking-analysis-of-aif-nls-complex-to-infer-nuclear-translocation-of-the-protein
#1
Akash Srivaths, Shyam Ramanathan, Seethalakshmi Sakthivel, Skm Habeeb
Apoptosis Inducing Factor protein has a dual role depending on its localization in mitochondrion (energy production) and nucleus (induces apoptosis). Cell damage transports this protein to nucleus which otherwise favors mitochondrion. The alteration of Nuclear Localisation Signal tags could aid nuclear translocation. In this study, apoptosis inducing factor protein (AIF) was conjugated with strong NLS tags and its binding affinity with Importin was studied using in silico approaches such as molecular modeling and docking...
2018: Bioinformation
https://www.readbyqxmd.com/read/29773051/dna-topoisomerases-of-leishmania-parasites-druggable-targets-for-drug-discovery
#2
Rosa Mª Reguer, Ehab Kotb Elmahallaw, Carlos Garcia-Estrada, Ruben Carbajo-Andres, Rafael Balana-Fouce
DNA topoisomerases (Top) are a group of isomerase enzymes responsible for controlling the topological problems caused by DNA double helix in the cell during the processes of replication, transcription and recombination. Interestingly, these enzymes have been known since long to be key molecular machines in several cellular processes through overwinding or underwinding of DNA in all-living organisms. Leishmania, a trypanosomatid parasite responsible for causing fatal diseases mostly in impoverished populations of low-income countries, have a set of six classes of Top enzymes...
May 17, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29771436/correlations-of-neuronal-apoptosis-with-expressions-of-c-fos-and-c-jun-in-rats-with-post-ischemic-reconditioning-damage
#3
P Xiao, X-W Liu, N-N Zhao, R Fang, Q Wen, K-X Zeng, Y-L Wang
OBJECTIVE: Transcription factors (c-Fos and c-Jun) have been considered to play roles in the initiation of programmed nerve cell death. However, the roles of c-Fos and c-Jun protein expressions in neuronal apoptosis of rats with post-ischemic reconditioning damage were not clarified. Therefore, the aim of this study was to investigate the correlations of protein expressions of c-Fos and c-Jun with neuronal apoptosis of rats with post-ischemic reconditioning damage. MATERIALS AND METHODS: Rat models of post-ischemic reconditioning were established firstly...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770610/arsenic-trioxide-coated-stent-is-an-endothelium-friendly-drug-eluting-stent
#4
Yinping Zhao, Ruolin Du, Tian Zhou, Dongchuan Yang, Yuhua Huang, Yi Wang, Junli Huang, Xiaoyi Ma, Fugui He, Juhui Qiu, Guixue Wang
An ideal vascular stent would both inhibit in-stent restenosis (ISR) and promote rapid re-endothelialization. In the current study, the performance of arsenic trioxide (ATO)-drug eluting stent (AES) is compared with the bare metal stent, poly-lactic-co-glycolic acid-coating metal stent, and rapamycin-drug eluting stent (RES). In vivo AES is shown to prevent neointimal hyperplasia more efficiently than the others when implanted into the carotid arteries of rabbits. Moreover, AES promotes endothelial cells proliferation and re-endothelialization more quickly than RES...
May 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29764546/-effect-of-pyrrolidine-dithiocarbamate-on-oxidative-stress-and-mitochondrial-function-of-lung-tissue-in-mice-with-acute-lung-injury
#5
Hongfu Yang, Ke Chao, Ming Liang, Rongqing Sun
OBJECTIVE: To investigate the effects of pyrrolidine dithiocarbamate (PDTC) on oxidative stress and mitochondrial function of lung tissue in mice with acute lung injury (ALI) induced by lipopolysaccharide (LPS). METHODS: Forty female Balb/c mice were randomly divided into normal saline (NS) control group, LPS model group, PDTC group, and PDTC+LPS group, with 10 mice in each group. The model of mice with ALI was reproduced by intraperitoneal injection of 15 mg/kg LPS...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29759112/remodelling-of-mitochondria-during-spermiogenesis-of-chinese-soft-shelled-turtle-pelodiscus-sinensis
#6
Abdul Haseeb, Hong Chen, Yufei Huang, Ping Yang, Xuejing Sun, Adeela Iqbal, Nisar Ahmed, Taozhi Wang, Noor Samad Gandahi, Xuebing Bai, Qiusheng Chen
Mitochondria are vital cellular organelles that have the ability to change their shape under different conditions, such as in response to stress, disease, changes in metabolic rate, energy requirements and apoptosis. In the present study, we observed remodelling of mitochondria during spermiogenesis and its relationship with mitochondria-associated granules (MAG). At the beginning of spermiogenesis, mitochondria are characterised by their round shape. As spermiogenesis progresses, the round-shaped mitochondria change into elongated and then swollen mitochondria, subsequently forming a crescent-like shape and finally developing into onion-like shaped mitochondria...
May 15, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29756269/genetic-and-clinical-features-of-chinese-patients-with-mitochondrial-ataxia-identified-by-targeted-next-generation-sequencing
#7
Hai-Lin Dong, Yin Ma, Quan-Fu Li, Yi-Chu Du, Lu Yang, Sheng Chen, Zhi-Ying Wu
AIM: To characterize the mutations in mitochondrial DNA (mtDNA) and mitochondrion-related nuclear genes (nDNA), and clinical features in Chinese patients with mitochondrial ataxia. METHODS: Targeted next-generation sequencing (NGS) technology was performed to screen the whole mtDNA sequence and nDNA genes in a cohort of 33 unrelated ataxia patients. RESULTS: A total of 5 pedigrees were finally genetically diagnosed as mitochondrial ataxia, with 3 pathogenic mutations (m...
May 13, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29751117/cell-death-mechanisms-in-leishmania-amazonensis-triggered-by-methylene-blue-mediated-antiparasitic-photodynamic-therapy
#8
Débora P Aureliano, José Angelo Lauletta Lindoso, Sandra Regina de Castro Soares, Cleusa Fumika Hirata Takakura, Thiago Martini Pereira, Martha Simões Ribeiro
Antiparasitic photodynamic therapy (ApPDT) is an emerging approach to manage cutaneous leishmaniasis (CL) since no side effects, contraindications and parasite resistance have been reported. In addition, methylene blue (MB) is a suitable photosensitizer to mediate ApPDT on CL. In this study we aimed to look for the best parameters to eradicate Leishmania amazonensis and investigated the cell death pathways involved in MB-mediated ApPDT. MB uptake by parasites was determined using different MB concentrations (50, 100, 250 and 500 μM) and incubation times (10, 30 and 60 min)...
May 8, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29750205/more-than-a-powerplant-the-influence-of-mitochondrial-transfer-on-the-epigenome
#9
Alexander N Patananan, Alexander J Sercel, Michael A Teitell
Each cell in the human body, with the exception of red blood cells, contains multiple copies of mitochondria that house their own genetic material, the maternally inherited mitochondrial DNA. Mitochondria are the cell's powerplant due to their massive ATP generation. However, the mitochondrion is also a hub for metabolite production from the TCA cycle, fatty acid beta-oxidation, and ketogenesis. In addition to producing macromolecules for biosynthetic reactions and cell replication, several mitochondrial intermediate metabolites serve as cofactors or substrates for epigenome modifying enzymes that regulate chromatin structure and impact gene expression...
June 2018: Current Opinion in Physiology
https://www.readbyqxmd.com/read/29747590/first-comprehensive-analysis-of-lysine-acetylation-in-alvinocaris-longirostris-from-the-deep-sea-hydrothermal-vents
#10
Min Hui, Jiao Cheng, Zhongli Sha
BACKGROUND: Deep-sea hydrothermal vents are unique chemoautotrophic ecosystems with harsh conditions. Alvinocaris longirostris is one of the dominant crustacean species inhabiting in these extreme environments. It is significant to clarify mechanisms in their adaptation to the vents. Lysine acetylation has been known to play critical roles in the regulation of many cellular processes. However, its function in A. longirostris and even marine invertebrates remains elusive. Our study is the first, to our knowledge, to comprehensively investigate lysine acetylome in A...
May 10, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29743445/increased-susceptibility-to-troglitazone-induced-mitochondrial-permeability-transition-in-type-2-diabetes-mellitus-model-rat
#11
Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito
Troglitazone, a member of the thiazolidinedione class of antidiabetic drugs, was withdrawn from the market because it causes severe liver injury. One of the mechanisms for this adverse effect is thought to be mitochondrial toxicity. To investigate the characteristics of troglitazone-induced liver toxicity in more depth, the toxicological effects of troglitazone on hepatocytes and liver mitochondria were investigated using a rat model of type 2 diabetes mellitus (T2DM). Troglitazone was found to increase mitochondrial permeability transition (MPT) in the liver mitochondria of diabetic rats to a greater extent than in control rats, whereas mitochondrial membrane potential and oxidative phosphorylation were not affected...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29742927/tetracaine-induces-apoptosis-through-a-mitochondrion-dependent-pathway-in-human-corneal-stromal-cells-in-vitro
#12
Zhan Song, Ting-Jun Fan
PURPOSE: Tetracaine is a local anesthetic widely used in ocular diagnosis and ophthalmic surgery and may lead to some adverse effects and complications at a clinical dose. To assess the cytotoxicity and molecular toxicity mechanisms of tetracaine, we used human corneal stromal (HCS) cells as an in vitro model to study the effects of tetracaine on HCS cells. MATERIALS AND METHODS: The cytotoxicity of tetracaine on HCS cells was investigated by examining the changes of cell growth, morphology, viability and cell cycle progressing when HCS cells were treated with tetracaine at concentrations from 10 g/L to 0...
May 9, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29739879/chemical-synapses-without-synaptic-vesicles-purinergic-neurotransmission-through-a-calhm1-channel-mitochondrial-signaling-complex
#13
Roman A Romanov, Robert S Lasher, Brigit High, Logan E Savidge, Adam Lawson, Olga A Rogachevskaja, Haitian Zhao, Vadim V Rogachevsky, Marina F Bystrova, Gleb D Churbanov, Igor Adameyko, Tibor Harkany, Ruibiao Yang, Grahame J Kidd, Philippe Marambaud, John C Kinnamon, Stanislav S Kolesnikov, Thomas E Finger
Conventional chemical synapses in the nervous system involve a presynaptic accumulation of neurotransmitter-containing vesicles, which fuse with the plasma membrane to release neurotransmitters that activate postsynaptic receptors. In taste buds, type II receptor cells do not have conventional synaptic features but nonetheless show regulated release of their afferent neurotransmitter, ATP, through a large-pore, voltage-gated channel, CALHM1. Immunohistochemistry revealed that CALHM1 was localized to points of contact between the receptor cells and sensory nerve fibers...
May 8, 2018: Science Signaling
https://www.readbyqxmd.com/read/29738737/iron-economy-in-naegleria-gruberi-reflects-its-metabolic-flexibility
#14
Jan Mach, Jarmila Bíla, Kateřina Ženíšková, Dominik Arbon, Ronald Malych, Marie Glavanakovová, Eva Nývltová, Robert Sutak
Naegleria gruberi is a free-living amoeba, closely related to the human pathogen Naegleria fowleri, the causative agent of the deadly human disease primary amoebic meningoencephalitis. Herein, we investigated the effect of iron limitation on different aspects of N. gruberi metabolism. Iron metabolism is among the most conserved pathways found in all eukaryotes. It includes the delivery, storage and utilization of iron in many cell processes. Nevertheless, most of the iron metabolism pathways of N. gruberi are still not characterized, even though iron balance within the cell is crucial...
May 5, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29733819/mitochondrial-proteome-disruption-in-the-diabetic-heart-through-targeted-epigenetic-regulation-at-the-mitochondrial-heat-shock-protein-70-mthsp70-nuclear-locus
#15
Danielle L Shepherd, Quincy A Hathaway, Cody E Nichols, Andrya J Durr, Mark V Pinti, Kristen M Hughes, Amina Kunovac, Seth M Stine, John M Hollander
>99% of the mitochondrial proteome is nuclear-encoded. The mitochondrion relies on a coordinated multi-complex process for nuclear genome-encoded mitochondrial protein import. Mitochondrial heat shock protein 70 (mtHsp70) is a key component of this process and a central constituent of the protein import motor. Type 2 diabetes mellitus (T2DM) disrupts mitochondrial proteomic signature which is associated with decreased protein import efficiency. The goal of this study was to manipulate the mitochondrial protein import process through targeted restoration of mtHsp70, in an effort to restore proteomic signature and mitochondrial function in the T2DM heart...
May 4, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29727614/3d-super-resolution-microscopy-reflects-mitochondrial-cristae-alternations-and-mtdna-nucleoid-size-and-distribution
#16
Andrea Dlasková, Hana Engstová, Tomáš Špaček, Anežka Kahancová, Vojtěch Pavluch, Katarína Smolková, Jitka Špačková, Martin Bartoš, Lydie Plecitá Hlavatá, Petr Ježek
3D super-resolution microscopy based on the direct stochastic optical reconstruction microscopy (dSTORM) with primary Alexa-Fluor-647-conjugated antibodies is a powerful method for accessing changes of objects that could be normally resolved only by electron microscopy. Despite the fact that mitochondrial cristae yet to become resolved, we have indicated changes in cristae width and/or morphology by dSTORM of ATP-synthase F1 subunit α (F1 α). Obtained 3D images were analyzed with the help of Ripley's K-function modeling spatial patterns or transferring them into distance distribution function...
May 1, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29722828/ros-and-redox-balance-as-multifaceted-players-of-cross-tolerance-epigenetic-and-retrograde-control-of-gene-expression
#17
V Locato, S Cimini, L De Gara
This review provides an update of the plant redox signalling network implicated in stress responses, in particular in cross-tolerance acquisition. The interplay between reactive oxygen species (ROS), ROS-derived signals and antioxidative pathways is discussed in plant acclimation to stress at short and long term. Retrograde pathways occurring between chloroplasts, mitochondria and nucleus involve oxidative and antioxidative signals that, working in a synergistic or antagonistic mode, control the expression of specific patterns of genes following stress perception...
May 2, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29718252/mitochondria-temperature-and-the-pace-of-life
#18
Dillon J Chung, Timothy M Healy, Jessica L McKenzie, Adam J Chicco, Genevieve C Sparagna, Patricia M Schulte
Life history strategies, physiological traits and behavior are thought to covary along a "pace of life" axis, with organisms at the fast end of this continuum having higher fecundity, shorter lifespan, and more rapid development, growth, and metabolic rates. Countergradient variation represents a special case of pace of life variation, in which high-latitude organisms occupy the fast end of the continuum relative to low-latitude conspecifics when compared at a common temperature. Here, we use Atlantic killifish (Fundulus heteroclitus) to explore the role of mitochondrial properties as a mechanism underlying countergradient variation, and thus variation in the pace of life...
April 30, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29717210/exploring-intrinsically-disordered-proteins-in-chlamydomonas-reinhardtii
#19
Zhang Yizhi, Launay Hélène, Schramm Antoine, Lebrun Régine, Gontero Brigitte
The content of intrinsically disordered protein (IDP) is related to organism complexity, evolution, and regulation. In the Plantae, despite their high complexity, experimental investigation of IDP content is lacking. We identified by mass spectrometry 682 heat-resistant proteins from the green alga, Chlamydomonas reinhardtii. Using a phosphoproteome database, we found that 331 of these proteins are targets of phosphorylation. We analyzed the flexibility propensity of the heat-resistant proteins and their specific features as well as those of predicted IDPs from the same organism...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29709058/cellular-atp-levels-are-affected-by-moderate-and-strong-static-magnetic-fields
#20
Dongmei Wang, Ze Wang, Lei Zhang, Zhiyuan Li, XiaoFei Tian, Jun Fang, Qingyou Lu, Xin Zhang
Mitochondrion is the major cellular energy producing organelle that is at the boundary between chemical reactions and physical processes. Although mitochondria have been shown to be affected by physical methods such as nonthermal plasma, whether static magnetic field (SMF) could also affect them is still unclear. Here we used rat adrenal PC12 cells to compare SMFs of different intensities for their effects on ATP (adenosine-5'-triphosphate), the major energy source produced by mitochondria, which is essential for various cellular processes...
April 30, 2018: Bioelectromagnetics
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