Markus Beutler, Ana R Homann, Marina Mihalic, Sara Plesnik, Laura Niebling, Martin Eckart, Vera Allerheiligen, Daniel Czurratis, Bhagwan Maharjan, Bhabana Shrestha, Nargiza Parpieva, Laziz Turaev, Zayniddin Sayfutdinov, Sabine Hofmann-Thiel, Wolfgang Grasse, Christoph Metzger-Boddien, Nils Paust, Harald Hoffmann
Xpert MTB/RIF testing (Xpert, Cepheid, Sunnyvale, CA) has improved tuberculosis (TB) diagnostics and rifampicin (Rif) resistance testing world-wide. However, it has weaknesses such as its restriction to Rif resistance testing and that the extracted DNA cannot be used for further testing. Here, a holistic diagnostic workflow including TB detection as well as genetic resistance testing towards Rif, isoniazid (Inh) and important second-line drugs (SLDs) based on a novel microfluidic DNA-extraction cartridge (TB-Disk) is presented...
February 23, 2021: Journal of Molecular Diagnostics: JMD