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https://www.readbyqxmd.com/read/28648027/-sirt1-signaling-pathway-mediated-the-protective-effects-on-myocardium-of-rats-after-endurance-training-and-acute-exhaustive-exercise
#1
X Y Li, X Han, H M Zhang, H Tan, S F Han
Objective: To detect the expression of SIRT1 and Ac-FOXO1 in rats after endurance training and acute exhaustive exercise, and explicit the myocardial protective effect of SIRT1. Methods: Rats were randomly divided into four groups: control group(n=20), exhaustive exercise group (E group, n=20), exhaustive exercise group + endurance training (TE group, n=18), exhaustive exercise group + endurance training + selective SIRT1 inhibitor (TSE group, n=17). The Control and E groups were fed routinely for 5 weeks. The TE and TSE groups were subjected to swimming exercise for 5 weeks for endurance exercising...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28647874/alleviative-effect-of-licorice-on-copper-chloride-induced-oxidative-stress-in-the-brain-biochemical-histopathological-immunohistochemical-and-genotoxic-study
#2
Heba El-Sayed Mostafa, Eman Ahmad Alaa-Eldin, Dalia Abdallah El-Shafei, Nehal S Abouhashem
Although copper is an essential micronutrient involved in a variety of biological processes indispensable for sustaining life, it can be toxic when administered in excess. Licorice (Glycyrrhizaglabra) has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. Here, we test the hypothesis that licorice could ameliorate copper-induced neurotoxic and genotoxic effects in adult male albino rats. For this purpose, 48 adult male albino rats were randomized into five groups: group I (8 rats), untreated control; group II (16 rats), subdivided into; vehicle control IIa (8 rats) which received 1 mL saline twice weekly intraperitoneally for 8 weeks and vehicle control IIb (8 rats) received 0...
June 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28647871/cytoskeleton-as-a-target-of-quinolinic-acid-neurotoxicity-insight-from-animal-models
#3
REVIEW
Paula Pierozan, Regina Pessoa-Pureur
Cytoskeletal proteins are increasingly recognized as having important roles as a target of the action of different neurotoxins. In the last years, several works of our group have shown that quinolinic acid (QUIN) was able to disrupt the homeostasis of the cytoskeleton of neural cells and this was associated with cell dysfunction and neurodegeneration. QUIN is an excitotoxic metabolite of tryptophan metabolism and its accumulation is associated with several neurodegenerative diseases. In the present review, we provide a comprehensive view of the actions of QUIN upstream of glutamate receptors, eliciting kinase/phosphatase signaling cascades that disrupt the homeostasis of the phosphorylation system associated with intermediate filament proteins of astrocytes and neurons...
June 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28647857/ros-modulated-therapeutic-approaches-in-cancer-treatment
#4
REVIEW
Muhammad Hassan Raza, Sami Siraj, Abida Arshad, Usman Waheed, Fahad Aldakheel, Shatha Alduraywish, Muhammad Arshad
PURPOSE: Reactive oxygen species (ROS) are produced in cancer cells as a result of increased metabolic rate, dysfunction of mitochondria, elevated cell signaling, expression of oncogenes and increased peroxisome activities. Certain level of ROS is required by cancer cells, above or below which lead to cytotoxicity in cancer cells. This biochemical aspect can be exploited to develop novel therapeutic agents to preferentially and selectively target cancer cells. METHODS: We searched various electronic databases including PubMed, Web of Science, and Google Scholar for peer-reviewed english-language articles...
June 24, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28647734/mir-4673-modulates-paclitaxel-induced-oxidative-stress-and-loss-of-mitochondrial-membrane-potential-by-targeting-8-oxoguanine-dna-glycosylase-1
#5
Hai-Li Huang, Ya-Peng Shi, Hui-Juan He, Ya-Hong Wang, Ting Chen, La-Wei Yang, Teng Yang, Jie Chen, Jun Cao, Wei-Min Yao, Gang Liu
BACKGROUND: Our previous study identified a novel microRNA, miR-4673, which is upregulated in A549 cells exposed to paclitaxel (PTX). In this study, we investigated the role of miR-4673 in PTX-induced cytotoxicity. METHODS: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, apoptosis assay, 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide (JC-1) staining and 2',7'-Dichlorofluorescein (DCFH) staining were used to evaluate cell viability, apoptosis, mitochondrial membrane potential (MMP) loss and reactive oxygen species (ROS) generation in A549 and H1299 cells...
June 26, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28647678/methyl-jasmonate-attenuated-lipopolysaccharide-induced-depressive-like-behaviour-in-mice
#6
Adaeze Adebesin, Olusegun A Adeoluwa, Anthony T Eduviere, Solomon Umukoro
Depression is a recurrent neuropsychiatric disorder that affects millions of individuals worldwide and impact negatively on the patients' social functions and quality of life. Studies have shown that i.p injection of lipopolysaccharide (LPS) induces depressive-like behavior in rodents via induction of oxidative stress and neuroinflammation. Methyl jasmonate (MJ), an isolated compound from jasmine plant has gained reputation in aromatherapy for treatment of depression, nervousness and memory deficits. This study was designed to evaluate the effects of MJ on LPS-induced depressive-like behavior in mice...
June 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28647579/frailty-is-associated-with-lower-expression-of-genes-involved-in-cellular-response-to-stress-results-from-the-toledo-study-for-healthy-aging
#7
Mariam El Assar, Javier Angulo, José Antonio Carnicero, Stefan Walter, Francisco José García-García, Eva López-Hernández, José-María Sánchez-Puelles, Leocadio Rodríguez-Mañas
BACKGROUND: Specific mechanisms underlying frailty syndrome are not well known. Frailty can be viewed as a loss of functional reserve resulting in increased vulnerability to stressors. We hypothesize that pathways regulating cellular response to stress are potential players in the development of frailty. The aim of this study was to evaluate the association of the expression of certain genes related to cellular response to stress with the presence of frailty in older patients. METHODS: A sample of 350 individuals aged 65 years or older (22% frail) was selected from the Toledo Study of Healthy Aging...
June 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28647350/antitumor-activity-of-resveratrol-is-independent-of-cu-ii-complex-formation-in-mcf-7-cell-line
#8
Priscylla Andrade Volkart, Rodrigo Benedetti Gassen, Bettina Mühlen Nogueira, Bárbara Nery Porto, José Eduardo Vargas, André Arigony Souto
Resveratrol (Rsv) is widely reported to possess anticarcinogenic properties in a plethora of cellular and animal models having limited toxicity toward normal cells. In the molecular level, Rsv can act as a suppressive agent for several impaired signaling pathways on cancer cells. However, Fukuhara and Miyata have shown a non-proteic reaction of Rsv, which can act as a prooxidant agent in the presence of copper (Cu), causing cellular oxidative stress accompanied of DNA damage. After this discovery, the complex Rsv-Cu was broadly explored as an antitumor mechanism in multiples tumor cell lines...
June 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28647191/pyrrolidine-dithiocarbamate-alleviates-the-anti-tuberculosis-drug-induced-liver-injury-through-jak2-stat3-signaling-pathway-an-experimental-study
#9
Hong Zhang, Yang Liu, Li-Kun Wang, Na Wei
OBJECTIVE: To study the effect of pyrrolidine dithiocarbamate (PDTC) on the anti-tuberculosis drug-induced liver injury and the molecular mechanism. METHODS: Clean male SD rats were selected as experimental animals and randomly divided into normal group, model group, PDTC group and AG490 group. Animal model of anti-tuberculosis drug-induced liver injury was established by intragastric administration isoniazid + rifampicin. PDTC group received intraperitoneal injection of PDTC, and AG490 group received intraperitoneal injection of AG490...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28647186/bougainvillea-spectabilis-flowers-extract-protects-against-the-rotenone-induced-toxicity
#10
Omar M E Abdel-Salam, Eman R Youness, Nadia A Ahmed, Sayed A El-Toumy, Ahmed M A Souleman, Nermeen Shaffie, Dalia M Abouelfadl
OBJECTIVE: To investigate the effect of two extracts of Bougainvillea spectabilis (B. spectabilis) flowers with yellow and pink/purple on brain oxidative stress and neuronal damage caused in rats by systemic rotenone injection. METHODS: Rotenone 1.5 mg/kg was given three times per week alone or in combination with B. spectabilis flowers extracts (25 mg or 50 mg) via the subcutaneous route for 2 weeks. Brain concentrations of the lipid peroxidation marker malondialdehyde (MDA), reduced glutathione, nitric oxide (nitrite), the pro-inflammatory cytokine interleukin-1beta (Il-1β) as well as butyrylcholinesterase, and paraoxonase-1 (PON-1) activities, were determined...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28647181/rosmarinic-acid-attenuates-hepatic-fibrogenesis-via-suppression-of-hepatic-stellate-cell-activation-proliferation-and-induction-of-apoptosis
#11
Naglaa M El-Lakkany, Walaa H El-Maadawy, Sayed H Seif El-Din, Olfat A Hammam, Salwa H Mohamed, Shahira M Ezzat, Marwa M Safar, Samira Saleh
OBJECTIVE: To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. METHODS: The impact of RA on stellate cell line (HSC-T6) proliferation, activation and apoptosis was assessed along with its safety on primary hepatocytes. In vivo, rats were divided into: (i) normal; (ii) thioacetamide (TAA)-intoxicated rats for 12 weeks; (iii) TAA + silymarin or (iv) TAA + RA...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28647125/isogenic-mutations-in-the-moraxella-catarrhalis-cyddc-system-display-pleiotropic-phenotypes-and-reveal-the-role-of-a-palindrome-sequence-in-its-transcriptional-regulation
#12
Yosra I Nagy, Manal M M Hussein, Yasser M Ragab, Ahmed S Attia
Moraxella catarrhalis is becoming an important human respiratory tract pathogen affecting significant proportions from the population. However, still little is known about its physiology and molecular regulation. To this end, the CydDC, which is a heterodimeric ATP binding cassette transporter that has been shown to contribute to the maintenance of the redox homeostasis across the periplasm in other Gram-negative bacteria, is studied here. Amino acids multiple sequence alignments indicated that M. catarrhalis CydC is different from the CydC proteins of the bacterial species in which this system has been previously studied...
September 2017: Microbiological Research
https://www.readbyqxmd.com/read/28646906/modulation-of-oxidative-phosphorylation-and-redox-homeostasis-in-mitochondrial-ndufs4-deficiency-via-mesenchymal-stem-cells
#13
Marlen Melcher, Katharina Danhauser, Annette Seibt, Özer Degistirici, Fabian Baertling, Arun Kumar Kondadi, Andreas S Reichert, Werner J H Koopman, Peter H G M Willems, Richard J Rodenburg, Ertan Mayatepek, Roland Meisel, Felix Distelmaier
BACKGROUND: Disorders of the oxidative phosphorylation (OXPHOS) system represent a large group among the inborn errors of metabolism. The most frequently observed biochemical defect is isolated deficiency of mitochondrial complex I (CI). No effective treatment strategies for CI deficiency are so far available. The purpose of this study was to investigate whether and how mesenchymal stem cells (MSCs) are able to modulate metabolic function in fibroblast cell models of CI deficiency. METHODS: We used human and murine fibroblasts with a defect in the nuclear DNA encoded NDUFS4 subunit of CI...
June 24, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28646813/hepatoprotective-activity-of-satwa-an-ayurvedic-formulation-against-alcohol-induced-liver-injury-in-rats
#14
Tejaswi Chavan, Abhijit Ghadge, Manjiri Karandikar, Vijaya Pandit, Prabhakar Ranjekar, Omkar Kulkarni, Aniket Kuvalekar, Nitin Mantri
Context • Guduchi Satwa is an Ayurvedic formulation prepared from Tinospora species. It has been used since ancient times to treat liver disorders. Objectives • The study intended to assess the hepatoprotective potential of Satwa prepared from 3 forms of Tinospora against alcohol-induced hepatotoxicity. Design • Male, albino Wistar rats were divided into 6 groups, with 6 rats each: 3 control groups-healthy controls, negative controls, and positive controls-and 3 intervention groups-Tinospora cordifolia, Tinospora sinensis, and Neem-Guduchi...
July 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646795/offsetting-the-impact-of-smoking-and-e-cigarette-vaping-on-the-cerebrovascular-system-and-stroke-injury-is-metformin-a-viable-countermeasure
#15
Mohammad A Kaisar, Heidi Villalba, Shikha Prasad, Taylor Liles, Ali Ehsan Sifat, Ravi K Sajja, Thomas J Abbruscato, Luca Cucullo
Recently published in vitro and in vivo findings strongly suggest that BBB impairment and increased risk for stroke by tobacco smoke (TS) closely resemble that of type-2 diabetes (2DM) and develop largely in response to common key modulators such oxidative stress (OS), inflammation and alterations of the endogenous antioxidative response system (ARE) regulated by the nuclear factor erythroid 2-related factor (Nrf2). Preclinical studies have also shown that nicotine (the principal e-liquid's ingredient used in e-cigarettes) can also cause OS, exacerbation of cerebral ischemia and secondary brain injury...
June 17, 2017: Redox Biology
https://www.readbyqxmd.com/read/28646756/protein-functionalization-of-zno-nanostructure-exhibits-selective-and-enhanced-toxicity-to-breast-cancer-cells-through-oxidative-stress-based-cell-death-mechanism
#16
Sailendra Mahanta, S Prathap, Deependra Kumar Ban, Subhankar Paul
Zinc oxide nanostructure (ZnONS) was chemically synthesized and functionalized (FZnONSBLA) with a small protein bovine α-lactalbumin (BLA) by chemical cross-linking methods. Both nano-structures were characterized using various techniques such as electron microscopy, dynamic light scattering (DLS), UV-Vis spectroscopy, FT-IR, photo-luminescence and X-ray diffraction. Electron microscopy and DLS analysis revealed their (ZnONS and FZnONSBLA) average size of 200nm and 450nm, respectively. When cytotoxicity of both the nanostructures were assessed in breast cancer cells MCF-7 and MDAMB231 by MTT assay and PI/Annexin V staining (FACS), FZnONSBLA demonstrated higher cell death than ZnONS primarily due to generation of intracellular reactive oxygen species (ROS)...
June 15, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28646746/variable-spontaneous-mutation-rate-in-clinical-strains-of-multidrug-resistant-acinetobacter-baumannii-and-differentially-expressed-proteins-in-a-hypermutator-strain
#17
Morteza Karami-Zarandi, Masoumeh Douraghi, Behrouz Vaziri, Habibeh Adibhesami, Mohammad Rahbar, Mehdi Yaseri
BACKGROUND: The emergence of multidrug resistant Acinetobacter baumannii within hospitals poses a significant threat to patients. The inherent rate of mutation of these strains has not been described nor has the mechanism by which drug resistance arises. METHODS: Here, we determined the spontaneous mutation rates in 93 clinical strains of A. baumannii using fluctuation analysis. To rule out the clonal relatedness of hypermutator strains, pulsed-field gel electrophoresis (PFGE) was conducted...
June 8, 2017: Mutation Research
https://www.readbyqxmd.com/read/28646724/zinc-and-calcium-alter-the-relationship-between-mitochondrial-respiration-ros-and-membrane-potential-in-rainbow-trout-oncorhynchus-mykiss-liver-mitochondria
#18
Mahmoud S Sharaf, Don Stevens, Collins Kamunde
At excess levels, zinc (Zn) disrupts mitochondrial functional integrity and induces oxidative stress in aquatic organisms. Although much is known about the modulation of Zn toxicity by calcium (Ca) in fish, their interactions at the mitochondrial level have scarcely been investigated. Here we assessed the individual and combined effects of Zn and Ca on the relationship between mitochondrial respiration, ROS and membrane potential (ΔΨmt) in rainbow trout liver mitochondria. We tested if cation uptake through the mitochondrial calcium uniporter (MCU) is a prerequisite for Zn- and/or Ca-induced alteration of mitochondrial function...
June 12, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28646629/mechanisms-of-inhibitory-effects-of-polycyclic-aromatic-hydrocarbons-in-the-photosynthetic-primary-processes-in-pea-leaves-and-thylakoid-preparations
#19
V D Kreslavski, M Brestic, S K Zharmukhamedov, V Yu Luybimov, A V Lankin, A Jajoo, S I Allakhverdiev
Inhibitory effects of Polycyclic aromatic hydrocarbons on plants is studied in pea leaves in order to elucidate the mechanisms of action of polycyclic aromatic hydrocarbons (PAHs) such as naphthalene (Naph) and phenanthrene (Phen) on activity of photosystem 2 (PS-2). The changes in different Chl fluorescence parameters were calculated on the basis of Chl fluorescence induction curves. Hydrogen peroxide content was measured in leaf homogenates by luminol-dependent chemiluminescence method. We demonstrated that due to PAH treatment, the total energy dissipation (DI0 /ABS) and amount of QB -non-reducing complexes of PS-2 significantly increased...
June 24, 2017: Plant Biology
https://www.readbyqxmd.com/read/28646624/prognostic-relevance-of-oxidative-stress-measurement-in-chronic-lymphocytic-leukemia
#20
Giovanni D'Arena, Candida Vitale, Omar Perbellini, Marta Coscia, Francesco La Rocca, Vitalba Ruggieri, Carlo Visco, Matteo Nicola Dario Di Minno, Idanna Innocenti, Vincenzo Pizza, Silvia Deaglio, Giovanni Di Minno, Aldo Giudice, Gioacchino Calapai, Pellegrino Musto, Luca Laurenti, Eugenio Luigi Iorio
OBJECTIVE: To evaluate the prognostic significance of oxidative stress (OS) and antioxidant defense status measurement in patients with chronic lymphocytic leukemia (CLL). METHOD: d-ROMs test and BAP test were evaluated at diagnosis of 165 patients with CLL and correlated with clinical-biological features and prognosis. RESULTS: An increased oxidative damage (d-ROMs test) and a reduced antioxidant potential (BAP test), were found in CLL patients than normal controls (p <0...
June 24, 2017: European Journal of Haematology
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