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https://www.readbyqxmd.com/read/28213525/conformational-profiling-of-the-at1-angiotensin-ii-receptor-reflects-biased-agonism-g-protein-coupling-and-cellular-context
#1
Dominic Devost, Rory Sleno, Darlaine Petrin, Alice Zhang, Yuji Shinjo, Rakan Okde, Junken Aoki, Asuka Inoue, Terence E Hebert
Here, we report the design and use of GPCR-based biosensors to monitor ligand-mediated conformational changes in receptors in intact cells. These biosensors use Bioluminescence Resonance Energy Transfer (BRET) with Renilla luciferase (RlucII) as an energy donor, placed at the distal end of the receptor C-tail and the small fluorescent molecule FlAsH, as an energy acceptor, its binding site inserted at different positions throughout the intracellular loops and carboxy-terminal tail of the angiotensin II type I receptor (AT1R)...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28186618/study-of-individualization-and-bias-in-nursing-home-fall-prevention-practices
#2
Cathleen S Colón-Emeric, Kirsten Corazzini, Eleanor McConnell, Wei Pan, Mark Toles, Rasheeda Hall, Melissa Batchelor-Murphy, Tracey L Yap, Amber L Anderson, Andrew Burd, Ruth A Anderson
OBJECTIVES: Little is known about how nursing home staff use resident characteristics to individualize care delivery or whether care is affected by implicit bias. DESIGN: Randomized factorial clinical vignette survey. SETTING: Sixteen nursing homes in North Carolina. PARTICIPANTS: Nursing, rehabilitation, and social services staff (n = 433). MEASUREMENTS: Vignettes describing hypothetical residents were generated from a matrix of clinical and demographic characteristics...
February 10, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28183444/effects-of-lifestyle-interventions-on-clinical-characteristics-of-patients-with-non-alcoholic-fatty-liver-disease-a-meta-analysis
#3
Christina N Katsagoni, Michael Georgoulis, George V Papatheodoridis, Demosthenes B Panagiotakos, Meropi D Kontogianni
BACKGROUND/OBJECTIVES: Although lifestyle modifications remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD), the optimal lifestyle intervention is still controversial. The aim of this meta-analysis was to evaluate the effect of exercise and/or dietary interventions, type or intensity of exercise and type of diet, on liver function outcomes (liver enzymes, intrahepatic fat and liver histology), as well as on anthropometric and glucose metabolism parameters in NAFLD patients...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28181175/adverse-effects-of-collagenase-in-the-treatment-of-dupuytren-disease-a-systematic-review
#4
REVIEW
Rafael Sanjuan-Cerveró, Francisco J Carrera-Hueso, Pedro Vazquez-Ferreiro, Diego Gomez-Herrero
BACKGROUND: Collagenase clostridium histolyticum (CCH) has proven to be both safe and effective in the treatment of Dupuytren disease (DD). The medium-term outcomes are similar to those achieved with surgery, and most adverse effects are self-limiting and considered to be mild or moderate. OBJECTIVE: Our objective was to conduct a systematic review of the adverse effects of CCH in DD since the release of the drug to evaluate the incidence, severity, classification, and definitions of these effects...
February 8, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28179475/asparagine-linked-glycans-of-cryptosporidium-parvum-contain-a-single-long-arm-are-barely-processed-in-the-er-or-golgi-and-show-a-strong-bias-for-sites-with-threonine
#5
John R Haserick, Deborah R Leon, John Samuelson, Catherine E Costello
Cryptosporidium parvum causes severe diarrhea in infants in developing countries and in immunosuppressed persons, including those with AIDS. We are interested in the Asn-linked glycans (N-glycans) of C. parvum, because 1) the N-glycan precursor is predicted to contain five mannose and two glucose residues on a single long arm versus nine mannose and three glucose residues on the three-armed structure common in host N-glycans, 2) C. parvum is a rare eukaryote that lacks the machinery for N-glycan-dependent quality control of protein folding in the lumen of the Endoplasmic Reticulum (ER), and 3) ER and Golgi mannosidases, as well as glycosyltransferases that build complex N-glycans, are absent from the predicted proteome...
February 8, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28176830/distribution-bias-analysis-of-germline-and-somatic-single-nucleotide-variations-that-impact-protein-functional-site-and-neighboring-amino-acids
#6
Yang Pan, Cheng Yan, Yu Hu, Yu Fan, Qing Pan, Quan Wan, John Torcivia-Rodriguez, Raja Mazumder
Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the SNV pattern differs between germline and somatic mutations as well as between synonymous and non-synonymous mutations. From a total of 51,138 protein functional site affecting SNVs (pfsSNVs), a pan-cancer analysis revealed 142 somatic pfsSNVs in five or more cancer types...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28174117/%C3%AE-arrestin-signalling-and-bias-in-hormone-responsive-gpcrs
#7
Eric Reiter, Mohammed Akli Ayoub, Lucie P Pellissier, Flavie Landomiel, Astrid Musnier, Aurélie Tréfier, Jorge Gandia, Francesco De Pascali, Shifa Tahir, Romain Yvinec, Gilles Bruneau, Anne Poupon, Pascale Crépieux
G protein-coupled receptors (GPCRs) play crucial roles in the ability of target organs to respond to hormonal cues. GPCRs' activation mechanisms have long been considered as a two-state process connecting the agonist-bound receptor to heterotrimeric G proteins. This view is now challenged as mounting evidence point to GPCRs being connected to large arrays of transduction mechanisms involving heterotrimeric G proteins as well as other players. Amongst the G protein-independent transduction mechanisms, those elicited by β-arrestins upon their recruitment to the active receptors are by far the best characterized and apply to most GPCRs...
February 4, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28170102/enhancement-of-self-conducted-exposure-for-ocd-using-cognitive-bias-modification-a-case-study
#8
Sadia Najmi, Nader Amir
The psychological treatment of choice for obsessive-compulsive disorder (OCD) is exposure and response prevention (ERP). However, the training required for practitioners to be proficient in delivering ERP is not readily available, thereby rendering the treatment inaccessible to most patients. Self-directed ERP (sERP) programs designed to increase the accessibility of ERP have not proven effective, perhaps because patients find it difficult to comply with exposure exercises without the guidance of a clinician...
February 7, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28170093/topical-treatments-for-blepharokeratoconjunctivitis-in-children
#9
REVIEW
Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28167328/attentional-biases-in-body-dysmorphic-disorder-bdd-eye-tracking-using-the-emotional-stroop-task
#10
Wei Lin Toh, David J Castle, Susan L Rossell
OBJECTIVE: Body dysmorphic disorder (BDD) is characterised by repetitive behaviours and/or mental acts occurring in response to preoccupations with perceived defects or flaws in physical appearance. This study aimed to examine attentional biases in BDD via the emotional Stroop task with two modifications: i) incorporating an eye-tracking paradigm, and ii) employing an obsessive-compulsive disorder (OCD) control group. METHOD: Twenty-one BDD, 19 OCD and 21 HC participants, who were age-, sex-, and IQ-matched, were included...
January 23, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28165260/psychometric-properties-of-the-triarchic-psychopathy-measure-an-item-response-theory-approach
#11
Yiyun Shou, Martin Sellbom, Jing Xu
: There is cumulative evidence for the cross-cultural validity of the Triarchic Psychopathy Measure (TriPM; Patrick, 2010) among non-Western populations. Recent studies using correlational and regression analyses show promising construct validity of the TriPM in Chinese samples. However, little is known about the efficiency of items in TriPM in assessing the proposed latent traits. The current study evaluated the psychometric properties of the Chinese TriPM at the item level using item response theory analyses...
February 6, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28163692/modifications-of-visual-field-asymmetries-for-face-categorization-in-early-deaf-adults-a-study-with-chimeric-faces
#12
Marjorie Dole, David Méary, Olivier Pascalis
Right hemisphere lateralization for face processing is well documented in typical populations. At the behavioral level, this right hemisphere bias is often related to a left visual field (LVF) bias. A conventional mean to study this phenomenon consists of using chimeric faces that are composed of the left and right parts of two faces. In this paradigm, participants generally use the left part of the chimeric face, mostly processed through the right optic tract, to determine its identity, gender or age. To assess the impact of early auditory deprivation on face processing abilities, we tested the LVF bias in a group of early deaf participants and hearing controls...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28153492/sex-and-age-dependent-gene-expression-in-human-liver-an-implication-for-drug-metabolizing-enzymes
#13
Yasuhiro Uno, Ryo Takata, Go Kito, Hiroshi Yamazaki, Kazuko Nakagawa, Yusuke Nakamura, Tetsuya Kamataki, Toyomasa Katagiri
Sex and age differences in hepatic expression of drug-metabolizing enzyme genes could cause variations in drug metabolism, but has not been fully elucidated, especially in Asian population. In this study, the global expression of human hepatic genes was analyzed by microarrays in 40 Japanese subjects (27 males and 13 females). Thirty-five sex-biased genes were identified (P < 0.005). Whereas, 60 age-biased genes in two age groups, <60 years and ≥70 years (P < 0.001), were identified in males...
February 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28149022/application-of-sigma-metrics-analysis-for-the-assessment-and-modification-of-quality-control-program-in-the-clinical-chemistry-laboratory-of-a-tertiary-care-hospital
#14
Sahar Iqbal, Tazeen Mustansar
Sigma is a metric that quantifies the performance of a process as a rate of Defects-Per-Million opportunities. In clinical laboratories, sigma metric analysis is used to assess the performance of laboratory process system. Sigma metric is also used as a quality management strategy for a laboratory process to improve the quality by addressing the errors after identification. The aim of this study is to evaluate the errors in quality control of analytical phase of laboratory system by sigma metric. For this purpose sigma metric analysis was done for analytes using the internal and external quality control as quality indicators...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28140354/the-enhanced-spin-polarized-transport-behaviors-through-cobalt-benzene-porphyrin-benzene-molecular-junctions-the-effect-of-functional-groups
#15
Fei Jue Cheng, Liping Zhou, Qian Wen, Qiang Yan, Qin Han, Lei Gao
The modification effects of the groups amino (NH2) and nitro (NO2) on the spin polarized transport properties of cobalt benzene-porphyrin-benzene (Co-BPB) molecule coupled to gold (Au) nanowires electrodes are investigated by the nonequilibrium Green���s function method combined with the density functional theory. The calculation results show that functional groups can lead to the significant spin-filter effect, enhanced low-bias negative differential resistance (NDR) behavior and novel reverse rectifying effect in Co-BPB molecular junction...
January 31, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28135269/an-asymmetrically-balanced-organization-of-kinases-versus-phosphatases-across-eukaryotes-determines-their-distinct-impacts
#16
Ilan Smoly, Netta Shemesh, Michal Ziv-Ukelson, Anat Ben-Zvi, Esti Yeger-Lotem
Protein phosphorylation underlies cellular response pathways across eukaryotes and is governed by the opposing actions of phosphorylating kinases and de-phosphorylating phosphatases. While kinases and phosphatases have been extensively studied, their organization and the mechanisms by which they balance each other are not well understood. To address these questions we performed quantitative analyses of large-scale 'omics' datasets from yeast, fly, plant, mouse and human. We uncovered an asymmetric balance of a previously-hidden scale: Each organism contained many different kinase genes, and these were balanced by a small set of highly abundant phosphatase proteins...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28124509/a-novel-single-cell-method-provides-direct-evidence-of-persistent-dna-damage-in-senescent-cells-and-aged-mammalian-tissues
#17
Alessandro Galbiati, Christian Beauséjour, Fabrizio d'Adda di Fagagna
The DNA damage response (DDR) arrests cell cycle progression until DNA lesions, like DNA double-strand breaks (DSBs), are repaired. The presence of DSBs in cells is usually detected by indirect techniques that rely on the accumulation of proteins at DSBs, as part of the DDR. Such detection may be biased, as some factors and their modifications may not reflect physical DNA damage. The dependency on DDR markers of DSB detection tools has left questions unanswered. In particular, it is known that senescent cells display persistent DDR foci, that we and others have proposed to be persistent DSBs, resistant to endogenous DNA repair activities...
January 26, 2017: Aging Cell
https://www.readbyqxmd.com/read/28111770/the-n2pc-component-reliably-captures-attentional-bias-in-social-anxiety
#18
Mario Reutter, Johannes Hewig, Matthias J Wieser, Roman Osinsky
We systematically compared different measures of attentional bias (i.e., reaction times, the N2pc component in the EEG, and explicit stimulus ratings) on their ability to reveal attentional engagement to threatening versus neutral facial stimuli in a Dot Probe Task and tested their relation to trait measures of general and social anxiety. We found that the N2pc component reflects a bias toward angry faces with excellent internal consistency. Similar results were obtained for explicit ratings. Reaction time (RT) differences, however, were not indicative of attentional biases and showed zero odd-even reliability...
January 22, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28106005/modification-of-the-saturation-magnetization-of-exchange-bias-thin-film-systems-upon-light-ion-bombardment
#19
Henning Huckfeldt, Alexander Gaul, Nicolas David Müglich, Dennis Holzinger, Dennis Nissen, Manfred Albrecht, Daniel Emmrich, André Beyer, Armin Gölzhäuser, Arno Ehresmann
The magnetic modification of exchange bias materials by 'ion bombardment induced magnetic patterning' has been established more than a decade ago. To understand these experimental findings several theoretical models were introduced. Few investigations, however, did focus on magnetic property modifications caused by effects of ion bombardment in the ferromagnetic layer. In the present study, the structural changes occurring under ion bombardment were investigated by Monte-Carlo simulations and in experiments...
March 29, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28104714/long-term-biased-%C3%AE-arrestin-signaling-improves-cardiac-structure-and-function-in-dilated-cardiomyopathy
#20
David M Ryba, Jieli Li, Conrad L Cowan, Brenda Russell, Beata M Wolska, R John Solaro
BACKGROUND: -Biased agonism of the angiotensin receptor (AT1R) is known to promote cardiac contractility. Our laboratory indicated that these effects may be due to changes at the level of the myofilaments. However, these signaling mechanisms remain unknown. As a common finding in dilated cardiomyopathy (DCM) is a reduction in the myofilament-Ca(2+)-response, we hypothesized that β-arrestin signaling would increase myofilament-Ca(2+)-responsiveness in a model of familial DCM and improve cardiac function and morphology...
January 19, 2017: Circulation
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