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Bias modification

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https://www.readbyqxmd.com/read/28424695/b-cell-tolerance-to-deiminated-histones-in-balb-c-c57bl-6-and-autoimmune-prone-mouse-strains
#1
Nishant Dwivedi, Annica Hedberg, Ying Yi Zheng, Indira Neeli, Minoru Satoh, Laurence Morel, Ole Petter Rekvig, Marko Radic
Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty's syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies to citrullinated protein antigens (ACPA). In general, ACPA are a sensitive diagnostic for RA and may form in response to the release of nuclear chromatin (DNA plus dH) from granulocytes, usually referred to as neutrophil extracellular traps...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28423038/attentional-bias-modification-training-for-insomnia-a-double-blind-placebo-controlled-randomized-trial
#2
Jaap Lancee, Samya L Yasiney, Ruben S Brendel, Marilisa Boffo, Patrick J F Clarke, Elske Salemink
BACKGROUND: Attentional bias toward sleep-related information is believed to play a key role in insomnia. If attentional bias is indeed of importance, changing this bias should then in turn have effects on insomnia complaints. In this double-blind placebo controlled randomized trial we investigated the efficacy of attentional bias modification training in the treatment of insomnia. METHOD: We administered baseline, post-test, and one-week follow-up measurements of insomnia severity, sleep-related worry, depression, and anxiety...
2017: PloS One
https://www.readbyqxmd.com/read/28421016/online-coaching-of-emotion-regulation-strategies-for-parents-efficacy-of-the-online-rational-positive-parenting-program-and-attention-bias-modification-procedures
#3
Oana A David, David Capris, Alexandra Jarda
Parenting programs are currently treatment of choice for behavioral disorders in children and one of their main components is reducing the negativity bias in the child-parent dyad. The Rational Positive Parenting Program (rPPP) is a program with a special focus on parent emotion-regulation functional reappraisal strategies, which has recently received consistent support for reducing child externalizing and internalizing disorders. In the last years, online interventions were proliferated and the Attention Bias Modification (ABM) becoming a promising implicit therapeutic intervention based on attention deployment emotion-regulation strategy, or adjunctive module to usual treatments, with results in multiple domains, varying from pain to self-esteem and emotional disorders (e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28410984/a-systematic-review-of-complications-associated-with-direct-implants-vs-tissue-expanders-following-wise-pattern-skin-sparing-mastectomy
#4
REVIEW
Jason Corban, Hani Shash, Tyler Safran, Nicolas Sheppard-Jones, Omar Fouda-Neel
INTRODUCTION: With proven oncological safety and improved aesthetic outcomes, the Type IV or "Wise pattern" skin-sparing mastectomy (SSM) is a procedure that is being performed with increasing frequency. Unfortunately, it is also associated with an increased risk of complications. The purpose of this investigation was to determine the complications associated with direct-to-implant and two-step tissue-expander breast reconstruction following Wise pattern SSM. METHODS: Systematic electronic searches were performed using PubMed, MEDLINE, and Embase databases...
March 14, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28407726/complementary-features-of-attention-bias-modification-therapy-and-cognitive-behavioral-therapy-in-pediatric-anxiety-disorders
#5
Lauren K White, Stefanie Sequeira, Jennifer C Britton, Melissa A Brotman, Andrea L Gold, Erin Berman, Kenneth Towbin, Rany Abend, Nathan A Fox, Yair Bar-Haim, Ellen Leibenluft, Daniel S Pine
OBJECTIVE: In the treatment of anxiety disorders, attention bias modification therapy (ABMT) and cognitive-behavioral therapy (CBT) may have complementary effects by targeting different aspects of perturbed threat responses and behaviors. ABMT may target rapid, implicit threat reactions, whereas CBT may target slowly deployed threat responses. The authors used amygdala-based connectivity during a threat-attention task and a randomized controlled trial design to evaluate potential complementary features of these treatments in pediatric anxiety disorders...
April 14, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28407629/combining-cystatin-c-and-creatinine-yields-a-reliable-glomerular-filtration-rate-estimation-in-older-adults-in-contrast-to-%C3%AE-trace-protein-and-%C3%AE-2-microglobulin
#6
Karin Werner, Mats Pihlsgård, Sölve Elmståhl, Helen Legrand, Ulf Nyman, Anders Christensson
BACKGROUND: The glomerular filtration rate (GFR) is the most important measure of kidney function and chronic kidney disease (CKD). This study aims to validate commonly used equations for estimated GFR (eGFR) based on creatinine (cr), cystatin C (cys), β-trace protein (BTP), and β2-microglobulin (B2M) in older adults. METHOD: We conducted a validation study with 126 participants aged between 72 and 98 with a mean measured GFR (mGFR) by iohexol clearance of 54 mL/min/1...
April 14, 2017: Nephron
https://www.readbyqxmd.com/read/28406292/functionalization-of-metal-organic-frameworks-to-achieve-controllable-wettability
#7
Heather N Rubin, Melissa M Reynolds
The overall versatility of a material can be immensely expanded by the ability to controllably tune its hydrophobicity. Herein we took advantage of steric bias to demonstrate that tricarboxylate metal-organic frameworks (MOFs) can undergo covalent postsynthetic modification to confer various degrees of hydrophobicity. MOF copper 2-aminobenzene-1,3,5-tricarboxylate was modified with varying-length aliphatic carbon chains. Unmodified Cu3(NH2BTC)2 degrades in minutes upon contact with water, whereas modification as low as 14% results in powders that show significantly enhanced hydrophobic character with contact angles up to 147°...
April 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28395773/improving-data-quality-and-preserving-hcd-generated-reporter-ions-with-ethcd-for-isobaric-tag-based-quantitative-proteomics-and-proteome-wide-ptm-studies
#8
Qing Yu, Xudong Shi, Yu Feng, K Craig Kent, Lingjun Li
Mass spectrometry (MS)-based isobaric labeling has undergone rapid development in recent years due to its capability for high throughput quantitation. Apart from its originally designed use with collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD), isobaric tagging technique could also work with electron-transfer dissociation (ETD), which provides complementarity to CID and is preferred in sequencing peptides with post-translational modifications (PTMs). However, ETD suffers from long reaction time, reduced duty cycle and bias against peptides with lower charge states...
May 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28392841/assessing-alternative-base-substitutions-at-primer-cpg-sites-to-optimise-unbiased-pcr-amplification-of-methylated-sequences
#9
Ida L M Candiloro, Thomas Mikeska, Alexander Dobrovic
BACKGROUND: Determining the role of DNA methylation in various biological processes is dependent on the accurate representation of often highly complex patterns. Accurate representation is dependent on unbiased PCR amplification post bisulfite modification, regardless of methylation status of any given epiallele. This is highly dependent on primer design. Particular difficulties are raised by the analysis of CpG-rich regions, which are the usual regions of interest. Here, it is often difficult or impossible to avoid placing primers in CpG-free regions, particularly if one wants to target a specific part of a CpG-rich region...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28391638/construction%C3%A2-of-er-3-yalo3-rgo-tio2-hybrid-electrode-with%C3%A2-enhanced%C3%A2-photoelectrocatalytic%C3%A2-performance%C3%A2-in-methylene%C3%A2-blue%C3%A2-degradation%C3%A2-under%C3%A2-visible%C3%A2-light
#10
Xian Zhou, Jun Zhang, Yue Ma, Hanqing Cheng, Shaozhu Fu, Dandan Zhou, Shuangshi Dong
Much attention has been paid on doping TiO2 to narrow its band gap to promote the absorption of visible light and restrain the recombination of electron-hole pairs to improve its efficiency in photoelectrocatalysis (PEC) under visible light irradiation. However, the oxidation potential energy of photo-induced holes for the modified catalysts by visible light excitation is lower than that without modification by UV excitation. In this work, we synthesized a co-coupled TiO2 electrode (denoted ERT) with the Er(3+) :YAlO3 and reduced graphene oxide (RGO), achieving the synergetic effect of visible-light-to-UV up conversion and response and great electron transfer ability...
April 9, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28388088/revisiting-partition-in-hydrated-bilayer-systems
#11
João T S Coimbra, Pedro A Fernandes, Maria J Ramos
We discuss potential-of-mean force convergence issues involving the methods for generating starting structures of umbrella sampling simulations for the study of the water-bilayer permeation of drug-like compounds. We provide a proof of concept of the benefits of potential-energy modification methods, in particular the flooding technique, to enhance the sampling and improve the convergence of the potential-of-mean force. In addition, we also discuss how these potential modifiers could introduce the necessary bias to induce the correct description of other relevant internal degrees of freedom for the compounds, thus providing a more accurate description of the permeation process...
April 13, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28384301/effects-of-cognitive-bias-modification-on-social-anxiety-a-meta-analysis
#12
Haining Liu, Xianwen Li, Buxin Han, Xiaoqian Liu
BACKGROUND: Cognitive bias modification (CBM), a set of techniques for modifying bias in information processing-is considered a novel intervention for social anxiety disorder (SAD), which has drawn considerable interest from researchers. However, the effects of CBM on SAD are not consistent. Some studies have demonstrated significant positive effects compared to control groups, while others have found no such effects. AIMS: We conducted a meta-analysis aimed at quantitatively assessing the effects of CBM on SAD at post-test...
2017: PloS One
https://www.readbyqxmd.com/read/28379786/unbiased-in-depth-characterization-of-cex-fractions-from-a-stressed-monoclonal-antibody-by-mass-spectrometry
#13
François Griaud, Blandine Denefeld, Manuel Lang, Héloïse Hensinger, Peter Haberl, Matthias Berg
Characterization of charge-based variants by mass spectrometry (MS) is required for the analytical development of a new biological entity and its marketing approval by health authorities. However, standard peak-based data analysis approaches are time-consuming and biased towards the detection, identification, and quantification of main variants only. The aim of this study was to characterize in-depth acidic and basic species of a stressed IgG1 monoclonal antibody using comprehensive and unbiased MS data evaluation tools...
April 5, 2017: MAbs
https://www.readbyqxmd.com/read/28369121/sequence-dependency-of-canonical-base-pair-opening-in-the-dna-double-helix
#14
Viveca Lindahl, Alessandra Villa, Berk Hess
The flipping-out of a DNA base from the double helical structure is a key step of many cellular processes, such as DNA replication, modification and repair. Base pair opening is the first step of base flipping and the exact mechanism is still not well understood. We investigate sequence effects on base pair opening using extensive classical molecular dynamics simulations targeting the opening of 11 different canonical base pairs in two DNA sequences. Two popular biomolecular force fields are applied. To enhance sampling and calculate free energies, we bias the simulation along a simple distance coordinate using a newly developed adaptive sampling algorithm...
April 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28368479/verapamil-use-is-associated-with-reduction-of-newly-diagnosed-diabetes-mellitus
#15
Ti Yin, Shu-Chen Kuo, Yea-Yuan Chang, Yung-Tai Chen, Kai-Wei Katherine Wang
Objective: The mechanism of the beneficial effect of calcium channel blockers (CCBs), especially verapamil, on the development of type 2 diabetes mellitus (T2DM) has been described. Previous clinical studies aiming to confirm these results were flawed by inappropriate comparator drugs or study designs. This study compared the incidence of T2DM in adults prescribed oral verapamil and propensity score-matched adults prescribed other oral CCBs. Methods: This retrospective population-based cohort study used Taiwan's National Health Insurance Research Database during 2000-2011...
March 24, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28364268/the-dopamine-d2-receptor-mediates-approach-avoidance-tendencies-in-smokers
#16
Armin Zlomuzica, Alla Machulska, Susanna Roberts, Michael von Glischinski, Mike Rinck, Kathryn J Lester, Thalia C Eley, Jürgen Margraf
Dopamine D2 receptors (DRD2) have been strongly implicated in reward processing of natural stimuli and drugs. Using the approach-avoidance task (AAT), we recently demonstrated that smokers show an increased approach-bias toward smoking-related cues but not toward naturally rewarding stimuli. Here, we examined the contribution of the DRD2 Taq1B polymorphism to smokers' and non-smokers' responsivity toward smoking versus naturally rewarding stimuli in the AAT. Smokers carrying the minor B1 allele of the DRD2 Taq1B polymorphism showed reduced approach behavior for food-related pictures compared to non-smokers with the same allele...
March 31, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28363772/characterization-of-signal-bias-at-the-glp-1-receptor-induced-by-backbone-modification-of-glp-1
#17
Marlies V Hager, Lachlan Clydesdale, Samuel H Gellman, Patrick M Sexton, Denise Wootten
The glucagon-like peptide-1 receptor (GLP-1R) is a cla B G protein-coupled receptor that is a major therapeutic target for the treatment of type 2 diabetes. Activation of this receptor promotes insulin secretion and blood glucose regulation. The GLP-1R can initiate signaling through several intracellular pathways upon activation by GLP-1. GLP-1R ligands that preferentially stimulate subsets among the natural signaling pathways ("biased agonists") could be useful as tools for elucidating the consequences of specific pathways and might engender therapeutic agents with tailored effects...
March 28, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28359282/a-modification-to-geographically-weighted-regression
#18
Yin-Yee Leong, Jack C Yue
BACKGROUND: Geographically weighted regression (GWR) is a modelling technique designed to deal with spatial non-stationarity, e.g., the mean values vary by locations. It has been widely used as a visualization tool to explore the patterns of spatial data. However, the GWR tends to produce unsmooth surfaces when the mean parameters have considerable variations, partly due to that all parameter estimates are derived from a fixed- range (bandwidth) of observations. In order to deal with the varying bandwidth problem, this paper proposes an alternative approach, namely Conditional geographically weighted regression (CGWR)...
March 31, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28356664/comparison-of-serum-creatinine-based-estimating-equations-with-gates-protocol-for-predicting-glomerular-filtration-rate-in-indian-population
#19
A V Mulay, S M Gokhale
In clinical practice, serum creatinine-based predicting equations and Gates protocol based on gamma camera imaging of kidneys after injection of Tc99m-diethylenetriaminepentaacetic acid (DTPA) are commonly used to assess glomerular filtration rate (GFR). Comparison of these methods, especially the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation with gold standard method of assessment of GFR by plasma clearance of Tc-99mDTPA is not well-studied in Indian population. We conducted this study to compare GFR estimation by gamma camera-based Gates protocol and serum creatinine-based predicting equations with GFR measured by plasma clearance of Tc-99mDTPA...
March 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28351693/quasi-experimental-study-designs-series-paper-6-risk-of-bias-assessment
#20
Hugh Waddington, Ariel Aloe, Betsy Jane Becker, Eric W Djimeu, Jorge Garcia Hombrados, Peter Tugwell, George Wells, Barney Reeves
OBJECTIVE: Rigorous and transparent bias assessment is a core component of high quality systematic reviews. We assess modifications to existing risk of bias approaches to incorporate rigorous quasi-experimental approaches with selection on unobservables. These are non-randomised studies using design-based approaches to control for unobservable sources of confounding such as difference studies, instrumental variables, interrupted time series, natural experiments and regression discontinuity designs...
March 25, 2017: Journal of Clinical Epidemiology
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