keyword
MENU ▼
Read by QxMD icon Read
search

ascorbic acid

keyword
https://www.readbyqxmd.com/read/28813744/alkaptonuria-a-case-report-with-diagnostic-challenge
#1
Vasantha L Gali, Amy M Kerkvliet, Jacob M Kusmak, Jana K Elwood
Alkaptonuria is a rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid (HGA) oxidase, the only enzyme capable of catabolizing HGA. Deficiency of this enzyme leads to excess HGA which deposits in the connective tissue. We present a case of a 64-year-old woman who was referred to the dermatology clinic for a full body mole check and skin cancer screening. Clinically she had blue/gray pigmentation of the external ear and sclera. Also she had a domed papule on the left cheek with punctate gray pigmentation which was biopsied...
August 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28813104/poly-methylene-blue-modified-electrode-for-indirect-electrochemical-sensing-of-oh-radicals-and-radical-scavengers
#2
Walter A Braun, Bruna C Horn, Lucélia Hoehne, Simone Stülp, Marcelo B DA Rosa, Maurício Hilgemann
A new modified electrode for indirect sensing of OH· and radical scavengers was described. The electrochemical polymerization of methylene blue in aqueous solutions and the properties of the resulting films on a glassy carbon electrode were carried out using cyclic voltammetry. A surface coverage of 1.11 × 109mol cm2 was obtained, revealing a complete surface coverage of the polymeric film on the electrode surface. OH· was able to destroy the poly(methylene blue) film by exposure to a Fenton solution. The loss of the electrochemical signal of the residual polymeric film attached to the electrode surface was related to the extent of its dissolution...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28812524/biologically-important-hydrazide-containing-fused-azaisocytosines-as-antioxidant-agents
#3
Małgorzata Sztanke, Krzysztof Sztanke
OBJECTIVES: Two important classes of hydrazide-containing fused azaisocytosines were evaluated as possible antioxidants and characterised by UV spectroscopy. METHODS: 2,2-Diphenyl-1-picrylhydazyl (DPPH), nitric oxide (NO), hydrogen peroxide (H2O2) scavenging potencies and reducing power of molecules were evaluated. RESULTS: The strongest DPPH scavengers were found to be 9, showing the potency superior to that of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) and comparable to that of ascorbic acid (AA), and 6, revealing the antioxidant potency superior to that of BHA, BHT, PG and Trolox...
August 16, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28812165/methane-enhances-aluminum-resistance-in-alfalfa-seedlings-by-reducing-aluminum-accumulation-and-reestablishing-redox-homeostasis
#4
Weiti Cui, Hong Cao, Ping Yao, Jincheng Pan, Quan Gu, Sheng Xu, Ren Wang, Zhaozeng Ouyang, Qingya Wang, Wenbiao Shen
Methane (CH4) is emerging as a candidate of signal molecule recently. However, whether or how CH4 enhances plant adaptation to aluminum (Al)-contaminated environment is still unknown. In this report, the physiological roles and possible molecular mechanisms of CH4 in the modulation of Al toxicity in alfalfa seedlings were characterized. Our results showed that, CH4 pretreatment could alleviate Al-induced seedling growth inhibition and redox imbalance. The defensive effects of CH4 against Al toxicity including the remission of Al-induced root elongation inhibition, nutrient disorder, and relative electrolyte leakage...
August 15, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28812050/caveats-in-the-established-understanding-of-cmt1a
#5
Jun Li
Charcot-Marie-Tooth disease type-1A (CMT1A) is one of the most common types of inherited peripheral nerve diseases. It is caused by the trisomy of chromosome 17p12 (c17p12), a large DNA segment of 1.4 Mb containing PMP22 plus eight other genes. The size of c17p12 is formidable for any cloning technique to manipulate, and thus precludes production of models in vitro and in vivo that can precisely recapitulate the genetic alterations in humans with CMT1A. This limitation and other factors have led to several assumptions, which have yet been carefully scrutinized, serving as key principles in our understanding of the disease...
August 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28809824/creation-and-transplantation-of-an-adipose-derived-stem-cell-asc-sheet-in-a-diabetic-wound-healing-model
#6
Yuka Kato, Takanori Iwata, Kaoru Washio, Toshiyuki Yoshida, Hozue Kuroda, Shunichi Morikawa, Mariko Hamada, Kazuki Ikura, Nobuyuki Kaibuchi, Masayuki Yamato, Teruo Okano, Yasuko Uchigata
Artificial skin has achieved considerable therapeutic results in clinical practice. However, artificial skin treatments for wounds in diabetic patients with impeded blood flow or with large wounds might be prolonged. Cell-based therapies have appeared as a new technique for the treatment of diabetic ulcers, and cell-sheet engineering has improved the efficacy of cell transplantation. A number of reports have suggested that adipose-derived stem cells (ASCs), a type of mesenchymal stromal cell (MSC), exhibit therapeutic potential due to their relative abundance in adipose tissue and their accessibility for collection when compared to MSCs from other tissues...
August 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28808421/crosstalk-between-mitochondrial-fission-and-oxidative-stress-in-paraquat-induced-apoptosis-in-mouse-alveolar-type-ii-cells
#7
Guangju Zhao, Kaiqiang Cao, Changqin Xu, Aifang Sun, Wang Lu, Yi Zheng, Haixiao Li, Guangliang Hong, Bing Wu, Qiaomeng Qiu, Zhongqiu Lu
Paraquat (PQ), as a highly effective and nonselective herbicide, induces cell apoptosis through generation of superoxide anions which forms reactive oxygen species (ROS). Mitochondria, as regulators for cellular redox signaling, have been proved to play an important role in PQ-induced cell apoptosis. This study aimed to evaluate whether and how mitochondrial fission interacts with oxidative stress in PQ-induced apoptosis in mouse alveolar type II (AT-II) cells. Firstly, we demonstrated that PQ promoted apoptosis and release of cytochrome-c (Cyt-c)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28808393/evaluation-of-the-antidiabetic-properties-of-s-1708-mulberry-variety
#8
Brijesh Ranjan, Randhir Kumar, Neeraj Verma, Swati Mittal, Pranab Lal Pakrasi, R Venkatesh Kumar
BACKGROUND: Diabetes is a metabolic disease prevalent worldwide in all age group of people. The source of diabetes is due to an oxidation process that can produce free radicals. An increase in oxidative free radicals in the body is reported to be one of the several causes of diabetes. The best remedy to combat oxidative stress is the use of antioxidants, which inhibit and scavenge free radicals. AIM: This study has been undertaken to evaluate the antioxidant activity and antidiabetic effect of mulberry leaf extract in diabetic mice...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807030/combined-effect-of-metformin-with-ascorbic-acid-versus-acetyl-salicylic-acid-on-diabetes-related-cardiovascular-complication-a-12-month-single-blind-multicenter-randomized-control-trial
#9
Syed Wasif Gillani, Syed Azhar Syed Sulaiman, Mohi Iqbal Mohammad Abdul, Mirza R Baig
BACKGROUND: We aimed to investigate the efficacy of ascorbic acid and acetylsalicylic acid among type II diabetes mellitus patients using metformin (only) for diabetes management therapy. METHOD: A 12-month single blinded multicenter randomized control trial was designed to investigate the measured variables [Glycated Hemoglobin (HbA1c), Renal function, Albumin Creatinine Ratio (ACR) etc.]. The trial was randomized into 2 experimental parallel arms (ascorbic acid vs acetylsalicylic acid) were blinded with study supplements in combination with metformin and findings were compared to control arm with metformin alone and blinded with placebo...
August 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28806719/comparison-of-reactive-oxygen-species-metabolism-during-grape-berry-development-between-kyoho-and-its-early-ripening-bud-mutant-fengzao
#10
Fei-Fei Xi, Li-Li Guo, Yi-He Yu, Yan Wang, Qiong Li, Hui-Li Zhao, Guo-Hai Zhang, Da-Long Guo
Enzymes and non-enzyme elements related to the metabolism of reactive oxygen species (ROS), such as catalase (CAT), superoxide dismutase (SOD), ascorbic acid (AsA), glutathione (GSH), NADPH oxidase (NOX), hydrogen peroxide (H2O2), superoxide anion (O2(-)), lipoxygenase (LOX) and malondialdehyde (MDA), were measured in 'Kyoho' and its early ripening bud mutant 'Fengzao' to compare ROS level changes and investigate the potential roles of ROS in grape berry development and the ripening process. In addition, the anthocyanin and sugar contents as well as berry diameter were also investigated at different berry development stages...
August 9, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28806657/two-dimensional-metal-chalcogenides-analogous-nise2-nanosheets-and-its-efficient-electrocatalytic-performance-towards-glucose-sensing
#11
Sakthivel Mani, Sukanya Ramaraj, Shen-Ming Chen, Bose Dinesh, Tse-Wei Chen
Recently, 2D layered transition-metal dichalcogenide materials have received great consideration because of their unique electronic properties, large surface area and high electrocatalytic activity. In this connection, for the first time the similar nanostructured material of NiSe2 nanosheets (NiSe2-NS) has been synthesized by a facile hydrothermal method for electrocatalytic applications. Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS), Energy Dispersive X-ray analysis (EDX), X-ray diffraction spectrum (XRD) results confirmed the formation of NiSe2-NS with required stoichiometry and morphology...
August 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28806526/highly-selective-self-powered-sensing-platform-for-p-nitrophenol-detection-constructed-with-a-photocathode-based-photocatalytic-fuel-cell
#12
Kai Yan, Yaohua Yang, Yuhan Zhu, Jingdong Zhang
A photocathode-based photocatalytic fuel cell (PFC) was fabricated and proposed as a self-powered sensor for p-nitrophenol (p-NP) detection. The PFC was comprised of a photocathode and an anode in separated chambers, which could generate suitable power output under photoirradiation to drive the sensing process. In this device, p-type PbS quantum dots-modified glass carbon electrode (GCE) served as the photocathode for the reduction of p-NP under photoirradiation while graphene-modified GCE was employed as the anode for the oxidation of ascorbic acid...
August 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28804532/associations-between-specific-redox-biomarkers-and-age-in-a-large-european-cohort-the-mark-age-project
#13
Daniela Weber, Wolfgang Stuetz, Olivier Toussaint, Florence Debacq-Chainiaux, Martijn E T Dollé, Eugène Jansen, Efstathios S Gonos, Claudio Franceschi, Ewa Sikora, Antti Hervonen, Nicolle Breusing, Thilo Sindlinger, María Moreno-Villanueva, Alexander Bürkle, Tilman Grune
Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28804003/effect-and-proposed-mechanism-of-vitamin-c-modulating-amino-acid-regulation-of-autophagic-proteolysis
#14
Md Razaul Karim, Motoni Kadowaki
Autophagy is an intracellular bulk degradation process, induced under nutrient starvation. Failure of autophagy has been recognized as a contributor to aging and multiple age related neurodegenerative diseases. Improving autophagy is a beneficial anti-aging strategy, however very few physiological regulators have been identified. Here, we demonstrate that vitamin C is a nutritional stimulator of autophagy. Supplementation of fresh hepatocytes with vitamin C increased autophagic proteolysis significantly in the presence of amino acids in a dose- and time-dependent manner, although no effect was observed in the absence of amino acids...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28803263/carotenoids-from-the-extreme-halophilic-archaeon-haloterrigena-turkmenica-identification-and-antioxidant-activity
#15
Giuseppe Squillaci, Roberta Parrella, Virginia Carbone, Paola Minasi, Francesco La Cara, Alessandra Morana
Haloterrigena turkmenica was able to synthesize carotenoids when grown in halobacteria medium. These molecules have antioxidant properties and find application in food, cosmetic, and pharmaceutical fields. The carotenoids were extracted with methanol, separated by RP-HPLC, and identified by mass spectrometry and UV/Vis spectra analyses. The C50 carotenoids were the main pigments, and C30, C40, and C51 carotenoids were also detected. Seven geometric isomers were distinguished for bacterioruberin, monoanhydrobacterioruberin, and bisanhydrobacterioruberin...
August 12, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28798883/magnetic-solid-phase-extraction-using-fe3o4-sio2-magnetic-nanoparticles-followed-by-uv-vis-spectrometry-for-determination-of-paraquat-in-plasma-and-urine-samples
#16
Ou Sha, Yu Wang, Xin Yin, Xiaobing Chen, Li Chen, Shujun Wang
A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28795782/variation-on-composition-and-bioactivity-of-essential-oils-of-four-common-curcuma-herbs
#17
Lanyue Zhang, Zhiwen Yang, Dingkang Chen, Zebin Huang, Yongliang Li, Xinzi Lan, Ping Su, Wanyi Pan, Wei Zhou, Xi Zheng, Zhiyun Du
Chemical compositions, antioxidative, antimicrobial, anti-inflammatory and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin and Curcuma kwangsiensis) rhizomes in China are comparatively studied. In total, 47, 49, 35 and 30 compounds are identified in C. longa, C. phaeocaulis, C. wenyujin and C. kwangsiensis essential oils by GC-MS, and their richest compounds are ar-turmerone (21.67%), elemenone (19.41%), curdione (40.23%) and (36...
August 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28794929/high-frequency-direct-shoot-organogenesis-of-leaf-explants-and-a-comparative-evaluation-of-phytochemicals-antioxidant-potential-of-wild-vs-in-vitro-plant-extracts-of-lysimachia-laxa
#18
Sanjoy Gupta, Tapan Seal, A A Mao, Soneswar Sarma
The present studies were attempted to develop direct shoot organogenesis from in vitro grown leaf explants of Lysimachia laxa and comparative evaluation of phytochemical and antioxidant potential of in vitro raised and wild plants extracts. The fresh leaves of this species are used for deworming gastrointestinal worm infection in traditional medicine. Overexploitation of this species and poor regeneration has led to rapid decline in wild population, therefore, present investigation was attempted to develop an efficient rapid mass propagation protocol for this species...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28794928/silicon-and-water-deficit-stress-differentially-modulate-physiology-and-ultrastructure-in-wheat-triticum-aestivum-l
#19
Ling Xu, Faisal Islam, Basharat Ali, Zengfei Pei, Juanjuan Li, Muhammad Awais Ghani, Weijun Zhou
Plants combat drought stress by coordinating various metabolic enzymes, and endogenous phytohormones, such as indole acetic acid (IAA) and abscisic acid (ABA). In the present study, 37-day-old wheat seedlings were subjected to the Hoagland solution with 20% PEG for 7 days (to create the artificial osmotic stress environment) in the greenhouse, and were supplemented with an optimized concentration (1.0 mM) of silicon (Si) to alleviate the negative effects of former stress on physiological, biochemical and phytohormones contents...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28794335/colorimetric-detection-of-ascorbic-acid-based-on-the-trigger-of-gold-nanoparticles-aggregation-by-cr-iii-reduced-from-cr-vi
#20
Ning Sui, Fengya Liu, Tailing Li, Lina Wang, Tao Wang, Manhong Liu, William W Yu
Au nanoparticles (AuNPs) dispersed in water were stabilized by tripolyphosphate (P3O10(5-)). When Cr2O7(2-) (Cr(VI)) was present, the AuNPs did not change; when Cr(3+) (Cr(III)) was present, the AuNPs would aggregate because of cooperative metal-ligand reaction. Aggregated AuNPs showed different color from the non-aggregated ones. Thus, a simple colorimetric assay was made using AuNPs-Cr(VI) to detect ascorbic acid (AA). Upon introducing AA to the AuNPs-Cr(VI) system, Cr(VI) was reduced to Cr(III), and the aggregation of AuNPs occurred...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
keyword
keyword
56870
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"