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https://www.readbyqxmd.com/read/27911052/synthesis-and-cytotoxicity-of-dendritic-platinum-nanoparticles-with-hek-293-cells
#1
Kyubin Shim, Jeonghun Kim, Yoon-Uk Heo, Bo Jiang, Cuiling Li, Mohammed Shahabuddin, Kevin C-W Wu, Md Shahriar A Hossain, Yusuke Yamauchi, Jung Ho Kim
Dendritic platinum nanoparticles (DPNs) have been synthesized from l-ascorbic acid and an amphiphilic non-ionic surfactant (Brij-58) via a sonochemical method. The particle size and shape of the DPNs could be tuned by changing the reduction temperature, resulting in a uniform DPN with a size of 23 nm or 60 nm. The facets of DPNs have been studied by high-resolution transmission electron microscopy. The cytotoxicity of DPNs has been investigated using human embryonic kidney cells (HEK-293), and the biological adaptability exhibited by DPNs has opened a pathway to biomedical applications such as drug-delivery systems, photothermal treatment, and biosensors...
December 2, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27907854/raman-spectroscopy-and-capillary-zone-electrophoresis-for-the-analysis-of-degradation-processes-in-commercial-effervescent-tablets-containing-acetylsalicylic-acid-and-ascorbic-acid
#2
Sabine Neuberger, Kevin Jooß, Dirk Flottmann, Gerhard Scriba, Christian Neusüß
In order to ensure the stability of pharmaceutical products appropriate manufacturing and storage conditions are required. In general, the degradation of active pharmaceutical ingredients (APIs) and subsequent formation of degradation products affect the pharmaceutical quality. Thus, a fast and effective detection and characterization of these substances is mandatory. Here, the applicability of Raman spectroscopy and CZE for the characterization of the degradation of effervescent tablets containing acetylsalicylic acid (ASA) and ascorbic acid (AA) was evaluated...
November 15, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27904413/influence-of-yellow-light-emitting-diodes-at-590-nm-on-storage-of-apple-tomato-and-bell-pepper-fruit
#3
Doris Kokalj, Janez Hribar, Blaž Cigić, Emil Zlatić, Lea Demšar, Lovro Sinkovič, Helena Šircelj, Grega Bizjak, Rajko Vidrih
The objective of this study is to investigate the effects of irradiation from light-emitting diodes (LEDs) on several fruits during storage. To improve storage and increase the contents of some bioactive compounds, apple, tomato and red bell pepper fruits were exposed to yellow light emitted from the diodes at 590 nm. The contents of ascorbic acid, total phenolics, total flavonoids and several pigments were investigated, along with the antioxidant potential. The colour parameters (L*, a* and b*) and firmness of the fruit were also determined...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904390/ascorbate-oxidase-based-amperometric-biosensor-for-l-ascorbic-acid-determination-in-beverages
#4
Gábor Csiffáry, Péter Fűtő, Nóra Adányi, Attila Kiss
A novel biosensor for l-ascorbic acid determination in different beverages was elaborated. The ascorbate oxidase enzyme (AAO) from Cucurbita sp., EC 1.10.3.3, was immobilized on a screen-printed carbon electrode with poly(ethylene glycol) (400) diglycidyl ether (PEGDGE) as a crosslinking agent. The standards and samples were measured first with a blank electrode. An inert protein, bovine serum albumin (BSA), was immobilized on the surface of this electrode with PEGDGE. The BSA mass was equivalent to the mass of 10 U of AAO enzyme immobilized on the electrodes (0...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904265/a-study-of-intravenous-administration-of-vitamin-c-in-the-treatment-of-acute-herpetic-pain-and-postherpetic-neuralgia
#5
Min Sung Kim, Dong Jin Kim, Chan Ho Na, Bong Seok Shin
BACKGROUND: Although there are several available management strategies for treatment of both acute pain of herpes zoster (HZ) and postherpetic neuralgia (PHN), it is difficult to treat them adequately. OBJECTIVE: The aim of this study was to evaluate the efficacy of intravenously administrated vitamin C on acute pain and its preventive effects on PHN in patients with HZ. METHODS: Between September 2011 and May 2013 eighty-seven patients who were admitted for HZ were assessed according to age, sex, underlying diseases, duration of pain and skin lesion, dermatomal distribution, and PHN...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27902966/photo-induced-toxicity-and-oxidative-stress-responses-in-tigriopus-japonicus-exposed-to-nitro-polycyclic-aromatic-hydrocarbons-and-artificial-light
#6
Toshimitsu Onduka, Daisuke Ojima, Katsutoshi Ito, Kazuhiko Mochida, Mana Ito, Jiro Koyama, Kazunori Fujii
Photo-induced toxicity is an important phenomenon in ecotoxicology because sunlight reaches many organisms in their natural habitats. To elucidate whether sunlight enhances the toxicity of nitro-polycyclic aromatic hydrocarbons (nitro-PAHs), the acute toxicities of 10 nitro-PAHs and the related compound 1-nitropyrene (1-NP) to Tigriopus japonicus were assessed in darkness or under light conditions. In addition, the relationships among the toxicity of 1-NP to T. japonicus, lighting condition, and the concentration of reactive oxygen species (ROS) formed were investigated in the presence or absence of the ROS scavenger ascorbic acid in the test solutions...
November 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/27900959/effect-of-vitamin-c-supplementation-on-lipid-profile-serum-uric-acid-and-ascorbic-acid-in-children-on-hemodialysis
#7
Ghada Mohamed El Mashad, Hanan M ElSayed, Nahla A Nosair
Children with end-stage renal disease (ESRD) suffer from dyslipidemia and hyperuricemia that might play a causal role in the progression of cardiovascular disease (CVD). The aim of the study is to assess the effects of Vitamin C supplementation on uric acid, ascorbic acid, and serum lipid levels among children on hemodialysis (HD). This prospective study was conducted in the pediatric nephrology unit at Menoufia University Hospital. The study included a total of 60 children with ESRD on maintenance HD therapy...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27900876/effects-of-production-methods-and-protective-ingredients-on-the-viability-of-probiotic-lactobacillus-rhamnosus-r0011-in-air-dried-alginate-beads
#8
Claude P Champagne, Yves Raymond, Yves Arcand
The goal of this study was to use a microencapsulation technology to prepare air-dried concentrated cultures of Lactobacillus rhamnosus R0011. The cultures were microencapsulated in alginate beads, which were added to a growth medium to allow cell multiplication inside the matrix; the beads were recovered, dipped in protective solutions, and air-dried. The effects of fermentation technology and of the composition of the protective solutions on subsequent survival during air-drying were examined. The cells prepared under a constant pH of 6...
August 26, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27899258/characterization-of-bioactive-constituents-from-the-gum-resin-of-gardenia-lucida-and-its-pharmacological-potential
#9
Priyanka Maurya, Shilpi Singh, Madan Mohan Gupta, Suaib Luqman
In the present study we mined the information on Gardenia lucida (Dikamali) and identified seven polymethoxyflavones from its gum resin. We also investigated its antiproliferative and antioxidant potential. Xanthomicrol (8) found as potent DPPH scavenger (85.86±1.3%) along with strong ferric plummeting ability (53.60±2.0 FSE) and reducing potential (1.07±0.01) as compared to ascorbic acid. Gardenin B (5) strongly inhibit biochemical production of nitric oxide (IC50 10.59±0.4μg/mL) followed by 5-Desmethylnobiletin (7) and Gardenin E (10, IC5011...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27899116/the-correlation-between-antimutagenic-activity-and-total-phenolic-content-of-extracts-of-31-plant-species-with-high-antioxidant-activity
#10
Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Luc Verschaeve, Jacobus Nicolaas Eloff
BACKGROUND: Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. There is increasing evidence that cancer and other mutation-related diseases can be prevented by intake of DNA protective agents. The identification of antimutagenic agents present in plants presents an effective strategy to inhibit pathogenic processes resulting from exposure to mutagenic and/or carcinogenic substances present in the environment. There are no reports on the antimutagenic activities of the plant species investigated in this study...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27899047/phytochemicals-and-antioxidant-capacity-in-four-italian-traditional-maize-zea-mays-l-varieties
#11
Antonella Capocchi, Stefania Bottega, Carmelina Spanò, Debora Fontanini
Flours of four pigmented (from orange to red and dark red) local Italian corns, studied for their soluble, soluble conjugate, and insoluble-bound phenols and flavonoids, showed a prevalence of the insoluble-bound fraction (70-80%). Correlations were found between the flours antioxidant capacity, measured with CUPRAC, FRAP, and DPPH methods, and soluble phenols and flavonoids content. A correlation was also found between ascorbic acid content and flours antioxidant power. Anthocyanins were present in small amounts in the red/dark red seeds; however, acid-alcohol assays and spectral analyses of pericarp extracts indicated the presence of red-brick phlobaphenes in these varieties...
November 29, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27898046/pro-and-antioxidant-activity-of-three-selected-flavan-type-flavonoids-catechin-eriodictyol-and-taxifolin
#12
Vladimir Chobot, Franz Hadacek, Gert Bachmann, Wolfram Weckwerth, Lenka Kubicova
The flavanol (±)-catechin shows an OH group but no 4-keto group on ring C (C3), and no conjugation between ring A and B. The related flavanone (+)-eriodictyol has a keto group on C4 but no 3-OH group on ring C. (+)-Taxifolin, another flavanone, has an OH on C3 and a keto group on C4 of the C ring. Deoxyribose degradation assay systems, with hydrogen peroxide and ascorbic acid either added or omitted, were performed in variants in which Fe(III) was added in a complex with ethylenediaminetetraacetic acid (EDTA)...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27895386/addition-of-strawberries-to-the-usual-diet-increases-postprandial-but-not-fasting-non-urate-plasma-antioxidant-activity-in-healthy-subjects
#13
Anna Prymont-Przyminska, Piotr Bialasiewicz, Anna Zwolinska, Agata Sarniak, Anna Wlodarczyk, Jaroslaw Markowski, Krzysztof P Rutkowski, Dariusz Nowak
Strawberries can augment plasma antioxidant activity, but this may be confounded by selection of methods, time of blood sampling and concomitant dietary restrictions. We examined the effect of strawberry consumption on ferric reducing ability (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (DPPH-test) of native and non-urate plasma in healthy subjects on their usual diet. Eleven subjects consumed strawberries (500 g daily) for 9 days. Fasting and 3-h postprandial plasma and 24-h urine collection were obtained before, during and after strawberry course for FRAP, DPPH-test and polyphenols determination...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27892705/modeling-the-degradation-kinetics-of-ascorbic-acid
#14
Micha Peleg, Mark D Normand, William R Dixon, Timothy R Goulette
Most published reports on ascorbic acid (AA) degradation during food storage and heat preservation suggest that it follows first-order kinetics. Deviations from this pattern include Weibullian decay, and exponential drop approaching finite non-zero retention. Almost invariably, the degradation rate constant's temperature-dependence followed the Arrhenius equation, and hence the simpler exponential model too. A formula and freely downloadable interactive Wolfram Demonstration to convert the Arrhenius model's energy of activation, Ea, to the exponential model's c parameter, or vice versa, are provided...
November 28, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27890109/ascorbic-acid-and-vitamin-c-containing-beverages-delay-the-leucomalachite-green-reaction-to-detect-latent-bloodstains
#15
Haeyong Lee, Myung Jin Park, Seol Hee Sun, Dong-Ho Choi, Yang-Han Lee, Ki-Won Park, Byung Won Chun
The leucomalachite green (LMG) test is one of catalytic tests for the detection of latent bloodstains and generally used in forensic field because of convenience and cost/time-effectiveness. However, contamination of latent bloodstains at crime scenes can interfere with the LMG reaction, resulting in false-negative or false-positive decisions. Herein, we examined if ascorbic acid and vitamin C (l-ascorbic acid or ascorbate)-containing beverages affect the LMG reaction. Ascorbic acid showed the inhibitory activities on the LMG reaction in a dose-dependent manner...
November 2016: Legal Medicine
https://www.readbyqxmd.com/read/27889546/comparison-of-a-split-dose-bowel-preparation-with-2l-polyethylene-glycol-plus-ascorbic-acid-and-1l-polyethylene-glycol-plus-ascorbic-acid-and-bisacodyl-before-colonoscopy
#16
Seung Hun Kang, Yoon Tae Jeen, Jae Hyung Lee, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim
BACKGROUND AND AIMS: Recently a low-volume polyethylene glycol containing ascorbic acid (PEG-Asc) formulation has proven as safe and effective as traditional 4L PEG solutions for colonoscopy preparation. However, currently available aqueous purgative formulations are poorly tolerated. The aim of this study was to compare a split-dose 2L PEG-Asc and a 1L PEG-Asc with bisacodyl (10 mg) formulation to determine the quality of bowel cleansing and patient tolerability. METHODS: A single-center, randomized, observer-blinded study was performed between May 2015 and September 2015...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27889183/increase-of-cytotoxicity-during-wastewater-chlorination-impact-factors-and-surrogates
#17
Ye Du, Qian-Yuan Wu, Yun Lu, Hong-Ying Hu, Yang Yang, Rui Liu, Feng Liu
Toxic and harmful disinfection byproducts (DBPs) were formed during wastewater chlorination. It was recently suggested that cytotoxicity to mammalian cells reflects risks posed by chlorinated wastewater. Here, ATP assays were performed to evaluate the cytotoxicity to mammalian cells. Chlorination significantly increased cytotoxicity of treated wastewater. Factors affecting cytotoxicity formation during wastewater chlorination were investigated. Quenching with sodium thiosulfate and ascorbic acid decreased the formed cytotoxicity, while ammonium kept the cytotoxicity stable...
November 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27888993/identifying-biomarkers-for-asthma-diagnosis-using-targeted-metabolomics-approaches
#18
William Checkley, Maria P Deza, Jost Klawitter, Karina M Romero, Jelena Klawitter, Suzanne L Pollard, Robert A Wise, Uwe Christians, Nadia N Hansel
BACKGROUND: The diagnosis of asthma in children is challenging and relies on a combination of clinical factors and biomarkers including methacholine challenge, lung function, bronchodilator responsiveness, and presence of airway inflammation. No single test is diagnostic. We sought to identify a pattern of inflammatory biomarkers that was unique to asthma using a targeted metabolomics approach combined with data science methods. METHODS: We conducted a nested case-control study of 100 children living in a peri-urban community in Lima, Peru...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27888536/ascorbate-degradation-in-tomato-leads-to-accumulation-of-oxalate-threonate-and-oxalyl-threonate
#19
Vincent Truffault, Stephen C Fry, Rebecca G Stevens, Hélène Gautier
Ascorbate content in plants is controlled by its synthesis from carbohydrates, recycling of the oxidized forms and degradation. Of these pathways, ascorbate degradation is the least studied and represents a lack of knowledge which could impair improvement of ascorbate content in fruits and vegetables as degradation is non-reversible and leads to a depletion of the ascorbate pool. The present study revealed the nature of degradation products using [(14) C]ascorbate labelling in tomato, a model plant for fleshy fruits; oxalate and threonate are accumulated in leaves, as is oxalyl threonate...
November 26, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27888503/anti-hypercholesterolemic-influence-of-the-spice-cardamom-elettaria-cardamomum-in-experimental-rats
#20
Shamarao Nagashree, Kottangada K Archana, Pullabhatla Srinivas, Krishnapura Srinivasan, Halagur B Sowbhagya
BACKGROUND: Cardamom (Elettaria cardamomum) is an aromatic seed spice grown extensively in India and used as a flavoring in sweets. The anti-hypercholesterolemic effect of cardamom was evaluated in Wistar rats by inducing hypercholesterolemia with a high cholesterol diet for 8 weeks. Dietary interventions were made with (a) Cardamom powder (50 g.kg(-1) ), (b) Cardamom oil (3 g.kg(-1) ) (equivalent to 50 g.kg(-1) cardamom), and (c) de-oiled cardamom powder (50 g.kg(-1) ). RESULTS: Significant reduction in the blood total cholesterol (31%) and LDL cholesterol (44%) was observed by oral administration of cardamom oil in hypercholesterolemic rats accompanied by a marked decrease in serum triglycerides by 42%...
November 26, 2016: Journal of the Science of Food and Agriculture
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