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ascorbic acid

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https://www.readbyqxmd.com/read/29166540/statistical-optimization-of-an-rp-hplc-method-for-the-determination-of-selected-flavonoids-in-berry-juices-and-evaluation-of-their-antioxidant-activities
#1
Andrija Ciric, Milena Jelikic-Stankov, Milica Cvijovic, Predrag Djurdjevic
An isocratic RP-HPLC method for the separation and identification of selected flavonoids (quercetin, rutin, luteolin-7-O-glucoside, kaempferol, and kaempferol-3-O-glucoside) in commercial berries juices (blackcurrant, blueberry, red raspberry and cherry) was developed with the aid of central composite design and response surface methodology. The optimal separation conditions were a mobile phase of 85:15 (% v/v) water/acetonitrile, pH of 2.8 (adjusted with formic acid), flow rate 0.5 mL/min and column temperature of 35 °C...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29165327/effects-of-dl-3-n-butylphthalide-on-cerebral-ischemia-infarction-in-rat-model-by-mass-spectrometry-imaging
#2
Run-Zhe Liu, Chao-Xin Fan, Zhi-Lin Zhang, Xin Zhao, Yi Sun, Hui-Hui Liu, Zong-Xiu Nie, Xiao-Ping Pu
Dl-3-n-butylphthalide (NBP) is a drug that is used in the treatment of ischaemic stroke. However, to the best of our knowledge, there are no systematic studies investigating the effects of dl-3-n-butylphtalide on the brain metabolism of small molecules. In this study, we first investigated the effects of dl-3-n-butylphthalide on the spatial distribution of small molecules in the brains of rats with permanent middle cerebral artery occlusion (pMCAO) using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) imaging...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29164854/nitrogen-doped-porous-carbon-zno-nanopolyhedra-derived-from-zif-8-new-materials-for-photoelectrochemical-biosensors
#3
Ruiying Yang, Xiaoxia Yan, Yanmei Li, Xiaohua Zhang, Jinhua Chen
Herein, novel photoactive materials, nitrogen-doped porous carbon-ZnO (NPC-ZnO) nanopolyhedra, were prepared by direct carbonization of ZIF-8 nanopolyhedra in a nitrogen atmosphere. The morphology, structure and photoelectrochemical (PEC) properties were characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, nitrogen adsorption-desorption method, and PEC methods. The results showed that the obtained NPC-ZnO nanopolyhedra had rhombic dodecahedron morphology with uniform particle size of about 100 nm and high surface area of 609...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29164598/vitamin-c-modulates-glutamate-transport-and-nmda-receptor-function-in-the-retina
#4
Ivan Domith, Renato Socodato, Camila C Portugal, Andressa F Munis, Aline T Duarte-Silva, Roberto Paes-de-Carvalho
Vitamin C (in the reduced form ascorbate or in the oxidized form dehydroascorbate) is implicated in signaling events throughout the central nervous system (CNS). In the retina, a high-affinity transport system for ascorbate has been described and glutamatergic signaling has been reported to control ascorbate release. Here we investigated the modulatory role played by vitamin C upon glutamate uptake and N-methyl-D-aspartate (NMDA) receptor activation in cultured retinal cells or in intact retinal tissue using biochemical and imaging techniques...
November 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29164211/various-polyoxomolybdate-based-hybrids-induced-by-ph-and-solvents-structures-adsorption-activities-for-dyes-and-bifunctional-electrocatalytic-properties
#5
Xiuli Wang, Shan Zhang, Xiang Wang, Guocheng Liu, Hongyan Lin, Huixiu Zhang
By changing the pH values and solvents of reaction systems, four polyoxomolybdate-based compounds, [CoL(H2O)2][β-Mo8O26]0.5 (1), {[Co2L2(H2O)3][Mo7O23]}·3H2O (2), [Co2L3][δ-Mo8O26]0.5[β-Mo8O26]0.5·10H2O (3), [Co2L3][H4Mo8O28]·4DMA·2H2O (4), (L = 1,3-bis(1H-imidazole-4-carboxamido)metaphenylene, DMA = N,N'-dimethylacetamide), have been synthesized in the presence of the Co(2+) ion, L ligand and Mo7O24(6-). Compounds 1 and 2 were obtained under hydrothermal conditions; the different pH values result in two kinds of polyoxomolybdate anions, [β-Mo8O26](4-) in 1 and [Mo14O46](8-) in 2, and the similar [CoL(H2O)2](2+) or [Co2L2(H2O)3](4+) metal-organic chains...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29164108/salicylic-acid-alleviates-aluminum-toxicity-in-soybean-roots-through-modulation-of-reactive-oxygen-species-metabolism
#6
Ning Liu, Fengbin Song, Xiancan Zhu, Jiangfeng You, Zhenming Yang, Xiangnan Li
As an important signal molecule, salicylic acid (SA) improves plant tolerance to aluminum (Al) stress. The objective of this study was to investigate the effects of exogenous SA application on the dynamics of endogenous SA and reactive oxygen species in soybean (Glycine max L.) exposed to Al stress. The roots of soybean seedlings were exposed to a combination of AlCl3 (30 μM) and SA (10 μM)/PAC (100 μM, paclobutrazol, SA biosynthesis inhibitor) for 3, 6, 9, and 12 h. Al stress induced an increase in endogenous SA concentration in a time-dependent manner, also verified by the up-regulated expression of GmNPR1, an SA-responsive gene...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29164106/complementary-sample-preparation-strategies-for-analysis-of-cereal-%C3%AE-glucan-oxidation-products-by-uplc-ms-ms
#7
Samy Boulos, Laura Nyström
The oxidation of cereal (1→3,1→4)-β-D-glucan can influence the health promoting and technological properties of this linear, soluble homopolysaccharide by introduction of new functional groups or chain scission. Apart from deliberate oxidative modifications, oxidation of β-glucan can already occur during processing and storage, which is mediated by hydroxyl radicals (HO(•)) formed by the Fenton reaction. We present four complementary sample preparation strategies to investigate oat and barley β-glucan oxidation products by hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), employing selective enzymatic digestion, graphitized carbon solid phase extraction (SPE), and functional group labeling techniques...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29163592/reciprocal-interactions-between-cadmium-induced-cell-wall-responses-and-oxidative-stress-in-plants
#8
REVIEW
Christophe Loix, Michiel Huybrechts, Jaco Vangronsveld, Marijke Gielen, Els Keunen, Ann Cuypers
Cadmium (Cd) pollution renders many soils across the world unsuited or unsafe for food- or feed-orientated agriculture. The main mechanism of Cd phytotoxicity is the induction of oxidative stress, amongst others through the depletion of glutathione. Oxidative stress can damage lipids, proteins, and nucleic acids, leading to growth inhibition or even cell death. The plant cell has a variety of tools to defend itself against Cd stress. First and foremost, cell walls might prevent Cd from entering and damaging the protoplast...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29161814/changes-in-aromatic-profile-sugars-and-bioactive-compounds-when-purple-garlic-is-transformed-into-black-garlic
#9
Lucia Martinez-Casas, Maria Lage-Yusty, Julia Lopez-Hernandez
Black garlic is a processed garlic product obtained from the treatment of fresh garlic (Allium sativum L.) under high temperature and high humidity conditions, which leads to modifications in colour, taste and texture. To clarify the physicochemical changes that occur during the thermal process, this study aimed to evaluate and compare the antioxidant activity and other compounds between purple garlic ecotype "Purple from Las Pedroñeras", and its black garlic derivative. Our results showed numerous differences between both, since black garlic presented a significant divergence in the volatile profile, a decreased amount of ascorbic acid, an increment in sugar and polyphenol contents, a greater antioxidant capacity and a different composition of phenolic acids and flavonoids...
November 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29160372/an-experimental-study-of-ascorbic-acid-effects-in-acute-renal-failure-under-general-anesthesia
#10
Omur Ozturk, Sefer Ustebay, Huseyin Avni Eroglu, Murat Günay, Yasemen Adali, İlksen Donmez, Mesut Erbas
PURPOSE: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. METHODS: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15th minute of inhalation anesthesia...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29158642/insights-into-nuclear-dna-content-hydrogen-peroxide-and-antioxidative-enzyme-activities-during-transverse-thin-cell-layer-organogenesis-and-ex-vitro-acclimatization-of-malaxis-wallichii-a-threatened-medicinal-orchid
#11
Biswajit Bose, Suman Kumaria, Hiranjit Choudhury, Pramod Tandon
Malaxis wallichii (Lindl.) Deb, a small, perennial, monopodial, terrestrial orchid, is endemic to tropical Himalayas at an altitude of 1200-2000 m asl. The pseudobulbs are important ingredients of century old drug 'Ashtavarga' and a polyherbal energetic tonic 'Chyavanprash'. An efficient genetically stable in vitro propagation protocol using transverse thin cell layer culture system was established for M. wallichii. In the present report, meta-topolin alone proved to be three times more beneficial compared to other routinely used cytokinins in inducing highest number of shoot buds, plant height and growth of regenerated shoots...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29158127/characterization-of-interactions-of-eggpc-lipid-structures-with-different-biomolecules
#12
F Corrales Chahar, S B Díaz, A Ben Altabef, C Gervasi, P E Alvarez
In this paper we study the interactions of two biomolecules (ascorbic acid and Annonacin) with a bilayer lipid membrane. Egg yolk phosphatidylcholine (eggPC) liposomes (in crystalline liquid state) were prepared in solutions of ascorbic acid (AA) at different concentration levels. On the other hand, liposomes were doped with Annonacin (Ann), a mono-tetrahydrofuran acetogenin (ACG), which is an effective citotoxic substance. While AA pharmacologic effect and action mechanisms are widely known, those of Ann's are only very recently being studied...
November 17, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29156608/fatty-acids-antioxidants-and-physical-activity-in-brain-aging
#13
REVIEW
Hércules Rezende Freitas, Gustavo da Costa Ferreira, Isis Hara Trevenzoli, Karen de Jesus Oliveira, Ricardo Augusto de Melo Reis
Polyunsaturated fatty acids and antioxidants are important mediators in the central nervous system. Lipid derivatives may control the production of proinflammatory agents and regulate NF-κB activity, microglial activation, and fatty acid oxidation; on the other hand, antioxidants, such as glutathione and ascorbate, have been shown to signal through transmitter receptors and protect against acute and chronic oxidative stress, modulating the activity of different signaling pathways. Several authors have investigated the role of these nutrients in the brains of the young and the aged in degenerative diseases such as Alzheimer's and Parkinson's, and during brain aging due to adiposity- and physical inactivity-mediated metabolic disturbances, chronic inflammation, and oxidative stress...
November 20, 2017: Nutrients
https://www.readbyqxmd.com/read/29155971/in-ovo-injection-of-ascorbic-acid-modulates-antioxidant-defense-system-and-immune-gene-expression-in-newly-hatched-local-chinese-yellow-broiler-chicks
#14
H K El-Senousey, B Chen, J Y Wang, A M Atta, F R Mohamed, Q H Nie
The present study was conducted to investigate the effects of in ovo injection of ascorbic acid on antioxidant capacity and immune-related gene expression in the newly hatched local Chinese yellow broiler chicks. Fertile Chinese yellow broiler eggs (n = 90) were assigned to three equal groups. The first group was a non-injected control group. The second group was another control group where the eggs were injected with saline in the air sac after 18 days of incubation. The third group was injected with 3 mg/egg AA in the air sac after 18 days of incubation...
November 15, 2017: Poultry Science
https://www.readbyqxmd.com/read/29155872/sulfur-dioxide-alleviates-programmed-cell-death-in-barley-aleurone-by-acting-as-an-antioxidant
#15
Sha-Sha Wang, Ying-Xin Zhang, Feng Yang, Zhong-Qin Huang, Jun Tang, Kang-Di Hu, Hua Zhang
Sulfur dioxide (SO2), a gaseous signaling molecule in animal cells, has recently been found to play a physiological role in plants. Here we studied the role of SO2 in gibberellic acid (GA3)-induced programmed cell death (PCD) in barley (Hordeum vulgare L.) aleurone layers. The application of the SO2 donor (NaHSO3/Na2SO3, 1:3 M/M) effectively alleviated PCD in barley aleurone layers in a dose-dependent manner with an optimal concentration of 50 μM. Further investigations showed that SO2 reduced the accumulation of hydrogen peroxide (H2O2), superoxide anion (⋅O2-) and malondialdehyde (MDA) in aleurone layers...
2017: PloS One
https://www.readbyqxmd.com/read/29153154/a-100-year-review-from-ascorbic-acid-to-zinc-mineral-and-vitamin-nutrition-of-dairy-cows
#16
W P Weiss
Mineral and vitamin nutrition of dairy cows was studied before the first volume of the Journal of Dairy Science was published and is still actively researched today. The initial studies on mineral nutrition of dairy cows were simple balance experiments (although the methods available at the time for measuring minerals were anything but simple). Output of Ca and P in feces, urine, and milk was subtracted from intake of Ca and P, and if values were negative it was often assumed that cows were lacking in the particular mineral...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29152252/effect-of-fish-oil-and-vitamin-e-on-sperm-lipid-peroxidation-in-dogs
#17
Analía Lorena Risso, Francisco J Pellegrino, Yanina Corrada, Mónica Marmunti, Mariana Gavazza, Alejandro Palacios, Alejandro E Relling
The objective was to evaluate the effects of dietary fish oil (FO) and vitamin E (VE) supplementation on sperm sensitivity to lipid peroxidation (LP) in dogs. Using an incomplete replicate 3 × 3 Latin square design, five dogs were allocated into three groups. One of the squares was incomplete and had two dogs that were used with three treatments. The dogs were assigned to three different treatments, fed a control diet of balanced commercial food (control group; CG), control diet supplemented with 54 mg FO/kg body weight(0·75) per d (FO group; FG) and FO plus 400 mg VE per d (FO and VE group; FEG) for 60 d...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29149994/a-novel-fluorescence-biosensor-for-sensitivity-detection-of-tyrosinase-and-acid-phosphatase-based-on-nitrogen-doped-graphene-quantum-dots
#18
Zhengyi Qu, Weidan Na, Xiaotong Liu, Hua Liu, Xingguang Su
In this paper, we developed a sensitive fluorescence biosensor for tyrosinase (TYR) and acid phosphatase (ACP) activity detection based on nitrogen-doped graphene quantum dots (N-GQDs). Tyrosine could be catalyzed by TYR to generate dopaquinone, which could efficiently quench the fluorescence of N-GQDs, and the degree of fluorescence quenching of N-GQDs was proportional to the concentration of TYR. In the presence of ACP, l-Ascorbic acid-2-phosphate (AAP) was hydrolyzed to generate ascorbic acid (AA), and dopaquinone was reduced to l-dopa, resulting in the fluorescence recovery of the quenched fluorescence by dopaquinone...
January 2, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29149763/formulation-and-anti-neurotoxic-activity-of-baicalein-incorporating-neutral-nanoliposome
#19
Farhang Aliakbari, Ali Akbar Shabani, Hassan Bardania, Hossein Mohammad-Beigi, Amir Tayaranian Marvian, Faezeh Dehghani Esmatabad, Abbas Ali Vafaei, Seyed Abbas Shojaosadati, Ali Akbar Saboury, Gunna Christiansen, Daniel E Otzen, Dina Morshedi
Despite extensive studies of the effects of herbal-derived small molecules in the biopharmaceutical and biomedical sciences, their low solubility and stability remain a challenge. Here we focus on baicalein, a small molecule showing potential against neurodegenerative diseases such as Parkinson's and Alzheimer's. However, therapeutic usage in vivo is challenged by low solubility and stability. To address this we have applied neutrally-charged nanoliposome (NLP) as carrier for baicalein. Baicalein was incorporated into NLP to form NLP-Ba at molar baicalain:lipid ratios of up to 1:3, giving a drug entrapment efficiency of 96...
November 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29149495/a-redox-activated-g-quadruplex-dna-binder-based-on-a-platinum-iv-salphen-complex
#20
Ramon Vilar, Stephane Bandeira, Jorge Gonzalez Garcia, Evangelina Pensa, Tim Albrecht
There has been increasing interest in the development of small molecules that can selectively bind to G-quadruplex DNA structures. The latter have been associated to a number of key biological processes and therefore are proposed to be potential targets for drug development. In this paper we report the first example of a reduction-activated G-quadruplex DNA binder. We show that a new octahedral platinum(IV)-salphen complex does not interact with DNA in aqueous media at pH 7.4; however, upon addition of bio-reductants such as ascorbic acid or glutathione, the compound readily reduces to the corresponding square planar platinum(II) complex...
November 17, 2017: Angewandte Chemie
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