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Citrullinated peptides

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https://www.readbyqxmd.com/read/29128424/the-use-of-synthetic-peptides-for-detection-of-anti-citrullinated-protein-antibodies-in-rheumatoid-arthritis
#1
Nicole Hartwig Trier, Bettina Eide Holm, Julie Heiden, Ole Slot, Henning Locht, Bente Jensen, Hanne Lindegaard, Anders Svendsen, Christoffer Tandrup Nielsen, Søren Jacobsen, Elke Theander, Gunnar Houen
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. A characteristic feature of RA is the presence of anti-citrullinated protein antibodies (ACPA). Since ACPAs are highly specific for RA and are often present before the onset of RA symptoms, they have become valuable diagnostic and prognostic. As a result, several assays for detection of ACPAs exist, which vary in sensitivity and specificity. In this study, we analyzed the reactivity of RA sera to selected peptides by solid-phase immunoassays in order to develop an ACPA assay with improved sensitivity and specificity...
November 8, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29122245/methods-for-segmentation-of-rheumatoid-arthritis-bone-erosions-in-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct
#2
Camille P Figueiredo, Arnd Kleyer, David Simon, Fabian Stemmler, Isabelle d'Oliveira, Anja Weissenfels, Oleg Museyko, Andreas Friedberger, Axel J Hueber, Judith Haschka, Matthias Englbrecht, Rosa M R Pereira, Juergen Rech, Georg Schett, Klaus Engelke
OBJECTIVE: The comparison between different techniques to quantify the 3-dimensional size of inflammatory bone erosions in rheumatoid arthritis(RA) patients. METHODS: Anti-cyclic citrullinated peptide antibody(ACPA) positive RA patients received high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the metacarpophalangeal joints (MCP). Erosions were measured by three different segmentation techniques: (1) manual method with calculation by half-ellipsoid formula, (2) semi-automated modified Evaluation Script for Erosions (mESE), and (3) semi-automated Medical Image Analysis Framework (MIAF) software...
September 23, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29120570/early-referral-improves-long-term-outcomes-in-rheumatoid-arthritis
#3
Jobie Evans, Andra Negoescu
Rheumatoid arthritis (RA) is a common, chronic systemic inflammatory disease of unclear aetiology leading to synovial hypertrophy and joint inflammation. It typically presents with symmetrical polyarthritis of small joints of the hands or feet, but can also involve larger joints, and have associated extra-articular manifestations. Diagnosis is based on duration of symptoms, joint distribution, level of inflammatory markers and autoantibodies i.e. rheumatoid factor(RhF) and anty-cyclic citrullinated peptide (CCP) antibodies...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29109281/peptidyl-arginine-deiminase-immunization-induces-anticitrullinated-protein-antibodies-in-mice-with-particular-mhc-types
#4
Fanny Arnoux, Charlotte Mariot, Elisa Peen, Nathalie C Lambert, Nathalie Balandraud, Jean Roudier, Isabelle Auger
Autoantibodies to citrullinated proteins (ACPAs) are present in two-thirds of patients with rheumatoid arthritis (RA). ACPAs are produced in the absence of identified T cell responses for each citrullinated protein. Peptidyl arginine deiminase 4 (PAD4), which binds proteins and citrullinates them, is the target of autoantibodies in early RA. This suggests a model for the emergence of ACPAs in the absence of detectable T cells specific for citrullinated antigens: ACPAs could arise because PADs are recognized by T cells, which help the production of autoantibodies to proteins bound by PADs, according to a "hapten/carrier" model...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29106059/increased-levels-of-neutrophil-extracellular-trap-remnants-in-the-serum-of-patients-with-rheumatoid-arthritis
#5
Wei Wang, Wanchan Peng, Xingwang Ning
AIMS: Neutrophil extracellular traps (NETs) comprise a unique form of non-apoptotic cell death exhibited by neutrophils, which occurs in a stepwise process termed NETosis. It has been postulated that NETosis plays an important role in the pathogenesis of autoimmune disorders. The aim of this study was to evaluate serum levels of NET remnants in patients with rheumatoid arthritis (RA), as well as potential associations between NET remnants and indicators of RA. METHODS: Serum levels of myeloperoxidase (MPO)-DNA complexes (NET remnants) were examined in 74 RA patients and 50 healthy controls using a modified enzyme-linked immunosorbent assay...
November 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29106028/association-of-high-anti-cyclic-citrullinated-peptide-seropositivity-and%C3%A2-lean-mass-index-with-low-bone-mineral-density-in-rheumatoid-arthritis
#6
Katherine D Wysham, Dolores M Shoback, John B Imboden, Patricia P Katz
OBJECTIVE: Osteoporotic fractures are associated with high morbidity and mortality. Persons with rheumatoid arthritis (RA) have twice the risk of osteoporosis-related fracture than age-matched controls, the causes for which remain unknown. We investigated contributions of RA characteristics, medication use, and body composition to low bone mineral density (BMD) in patients with RA. METHODS: Data were from the Arthritis, Body Composition, and Disability Study (n=138; 82 women, 56 men)...
November 5, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29102586/association-of-the-shared-epitope-smoking-and-the-interaction-between-the-two-with-the-presence-of-autoantibodies-anti-ccp-and-fr-in-patients-with-rheumatoid-arthritis-in-a-hospital-in-seville-spain
#7
José Luis García de Veas Silva, Concepción González Rodríguez, Blanca Hernández Cruz
OBJECTIVES: To evaluate the association of shared epitope, smoking and their interaction on the presence of autoantibodies (anti-cyclic citrullinated peptide [CCP] antibodies and rheumatoid factor) in patients with rheumatoid arthritis in our geographical area. METHODS: A descriptive and cross-sectional study was carried out in a cohort of 106 patients diagnosed with RA. Odds ratios (OR) for antibody development were calculated for shared epitope, tobacco exposure and smoking dose...
November 1, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29098841/-effect-of-sanbitang-recipe-in-treatment-of-rheumatoid-arthritis-with-kidney-empty-and-cold-dampness-symptom
#8
Shuai-Gang Du, Zhong-Hua Guo, Qian-Qian Kong, Xue-Chang Wang, Song-Lin Zhou, Yu-Ming Liu
To explore the clinical effect of Sanbitang recipe in treatment for the rheumatoid arthritis (RA) with kidney empty and cold-dampness symptom and its safety. A total 168 cases eligible patients were randomly divided into the traditional Chinese medicine (TCM) group, the chemical medicine group and the TCM combined with chemical medicine group, with 56 cases in each group. The TCM group was treated with Sanbitang recipe; The chemical medicine group was given methotrexate tablets; And Sanbitang recipe and methotrexate tablets was adopted in the TCM combined with chemical medicine group...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29093151/effect-of-anticitrullinated-protein-antibody-status-on-response-to-abatacept-or-antitumor-necrosis-factor-%C3%AE-therapy-in-patients-with-rheumatoid-arthritis-a-us-national-observational-study
#9
Leslie R Harrold, Heather J Litman, Sean E Connolly, Sheila Kelly, Winnie Hua, Evo Alemao, Lisa Rosenblatt, Sabrina Rebello, Joel M Kremer
OBJECTIVE: Assess whether baseline anticyclic citrullinated peptide antibodies (anti-CCP) status is associated with treatment response in patients with rheumatoid arthritis (RA) initiating abatacept (ABA) or a tumor necrosis factor-α inhibitor (TNFi). METHODS: Using the Corrona RA registry, patients were identified who initiated ABA or a TNFi (June 2004-January 2015), had a followup visit 6 months (± 3 mos) after initiation, and anti-CCP measured at or prior to initiation...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29084415/association-of-distinct-fine-specificities-of-anti-citrullinated-peptide-antibodies-with-elevated-immune-responses-to-prevotella-intermedia-in-a-subgroup-of-patients-with-rheumatoid-arthritis-and-periodontitis
#10
Anja Schwenzer, Anne-Marie Quirke, Anna M Marzeda, Alicia Wong, Anna B Montgomery, Harlan R Sayles, Sigrun Eick, Katarzyna Gawron, Maria Chomyszyn-Gajewska, Katarzyna Łazarz-Bartyzel, Simon Davis, Jan Potempa, Benedikt M Kessler, Roman Fischer, Patrick J Venables, Jeffrey B Payne, Ted R Mikuls, Kim S Midwood
OBJECTIVE: In addition to the long-established link with smoking, periodontitis (PD) is a risk factor for rheumatoid arthritis (RA). This study was undertaken to elucidate the mechanism by which PD could induce antibodies to citrullinated peptides (ACPAs), by examining the antibody response to a novel citrullinated peptide of cytokeratin 13 (CK-13) identified in gingival crevicular fluid (GCF), and comparing the response to 4 other citrullinated peptides in patients with RA who were well-characterized for PD and smoking...
October 30, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29077694/practical-approach-to-the-evaluation-and-management-of-rheumatoid-arthritis-interstitial-lung-disease-based-on-its-proven-and-hypothetical-mechanisms
#11
Francisco Paulin, Alejandra Babini, Marta Mamani, Juan Mercado, Fabián Caro
The prevalence of interstitial lung disease in patients with rheumatoid arthritis varies from 10 to 42%. Rheumatoid arthritis patients with interstitial lung disease have three times the risk of death compared with those without the disease. Prognosis seems to be related to the high-resolution computed tomography pattern. Usual interstitial pneumonia pattern, resembling idiopathic pulmonary fibrosis, carries a worse prognosis. Validated strategies to identify different phenotypes and assess the disease activity in rheumatoid arthritis interstitial lung disease are lacking...
September 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29074350/effects-of-charge-and-hydrophobicity-on-the-oligomerization-of-peptides-derived-from-iapp
#12
Yilin Wang, Nicholas L Truex, Ngoc D P Vo, James S Nowick
Changes in pH resulting in modifications of charge can dramatically alter the folding and interaction of proteins. This article probes the effects of charge and hydrophobicity on the oligomerization of macrocyclic β-sheet peptides derived from residues 11-17 of IAPP (RLANFLV). Previous studies have shown that a macrocyclic β-sheet peptide containing this IAPP sequence (peptide 1Arg) does not form oligomers in aqueous solution at low millimolar concentrations. Replacing arginine with the uncharged isostere citrulline generates a homologue (peptide 1Cit) that forms a tetramer consisting of a sandwich of hydrogen-bonded dimers...
October 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29070529/anticitrullinated-protein-peptide-antibody-multiplexing-defines-an-extended-group-of-acpa-positive-rheumatoid-arthritis-patients-with-distinct-genetic-and-environmental-determinants
#13
Johan Rönnelid, Monika Hansson, Linda Mathsson-Alm, Martin Cornillet, Evan Reed, Per-Johan Jakobsson, Lars Alfredsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Karin Lundberg, Lars Klareskog
INTRODUCTION: The second generation anticycliccitrullinated peptide (anti-CCP2) assay detects the majority but not all anticitrullinated protein/peptide antibodies (ACPA). Anti-CCP2-positive rheumatoid arthritis (RA) is associated with HLA-DRB1* shared epitope (SE) alleles and smoking. Using a multiplex assay to detect multiple specific ACPA, we have investigated the fine specificity of individual ACPA responses and the biological impact of additional ACPA reactivity among anti-CCP2-negative patients...
October 25, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29069018/thyroid-disorders-in-patients-with-newly-diagnosed-rheumatoid-arthritis-is-associated-with-poor-initial-treatment-response-evaluated-by-disease-activity-score-in-28-joints-c-reactive-protein-das28-crp-an-observational-cohort-study
#14
Amir Emamifar, Jørgen Hangaard, Inger Marie Jensen Hansen
To determine the prevalence of thyroid disorders among newly diagnosed rheumatoid arthritis (RA) patients and evaluate the association between clinical characteristics of RA and thyroid disorders, and also initial treatment response in the RA patients with thyroid disorders.Newly diagnosed, adult RA patients who were diagnosed according to the new 2010 American College of Rheumatology/European League Against Rheumatism criteria since January 1, 2010, were included. Patients' demographic data, serology results including immunoglobulin M rheumatoid factor (IgM RF), anticyclic citrullinated peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danish Danbio Registry...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29068601/rheumatoid-factor-and-anti-cyclic-citrullinated-peptide-anti-ccp-antibodies-with-hepatitis-b-and-hepatitis-c-infection-review
#15
Orhan Zengin, Hamit Yıldız, Zeynep Hanım Demir, Muhammed Sait Dağ, Musa Aydınlı, Ahmet Mesut Onat, Bünyamin Kısacık
BACKGROUND: Viruses are common and are involved in the etiology of idiopathic rheumatological diseases. Hepatitis B virus (HBV), a member of the family Hepadnaviridae and hepatitis C virus (HCV), play an important role in the undetermined etiology of arthritis. The clinical manifestations of hepatitis B and C show similarities with various diseases, such as rheumatic diseases. Anti-cyclic citrullinated peptide (anti-CCP) is a specific serological marker for rheumatoid arthritis. OBJECTIVES: The aim of this study was to analyze anti-CCP and rheumatoid factor (RF) levels in patients with a hepatitis B and C infection...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29057725/prevalence-of-nasal-colonization-with-staphylococcus-aureus-in-patients-with-rheumatoid-arthritis
#16
Gloria Albert, Milagros Ricse, Javier Narvaez, Jesus Rodriguez, Joan Miquel Nolla, Mari Angeles Dominguez-Luzon, Carmen Gomez Vaquero
OBJECTIVE: Patients with rheumatoid arthritis (RA) and nasal carriers of Staphylococcus aureus have an increased risk of developing infections caused by S. aureus. Our objective was to determine the prevalence of S. aureus nasal colonization in patients with RA and its relationship to RA treatments. METHODS: Two hundred seven patients with RA and 37 healthy controls were prospectively included in a cross-sectional study. A nasal secretion sample was collected by swab from both anterior nostrils and was referred to the hospital's microbiology department for culturing...
October 20, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29041980/comparison-of-the-clinical-effectiveness-of-us-grading-scoring-system-vs-mri-in-the-diagnosis-of-early-rheumatoid-arthritis-ra
#17
Huajun Xu, Yingchun Zhang, Huimei Zhang, Caishan Wang, Pan Mao
BACKGROUND: As an irreversible disease, a treatment delay can negatively affect treatment response in rheumatoid arthritis (RA). Ultrasound and MRI have played an important role in assessing disease progression and response to treatment in RA for many years. The present study was designed to compare the diagnostic efficacy of ultrasound grading and MRI in early RA. METHODS: In this retrospective study, 62 early RA patients within 12 months of symptom onset were included...
October 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29033912/the-infectious-basis-of-acpa-positive-rheumatoid-arthritis
#18
REVIEW
Lazaros I Sakkas, Dimitrios Daoussis, Stamatis-Nick Liossis, Dimitrios P Bogdanos
Rheumatoid arthritis (RA) is associated with HLA-DRB1 shared epitope (HLA-DRB1SE) and anti-citrullinated protein autoantibodies (ACPAs). ACPAs precedes the onset of clinical and subclinical RA. There are strong data for three infectious agents as autoimmunity triggers in RA, namely Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans causes of periodontal disease (PD), and Epstein-Barr virus (EBV). P. gingivalis expresses arginine gingipains, that cleave proteins at the arginine residues, and peptidyl arginine deiminase (PPAD), which citrullinates arginine residues of proteins, thus forming neoantigens that lead to ACPA production...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033678/quantitative-metabolic-volumetric-product-on-18-fluorine-2fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-in-assessing-treatment-response-to-disease-modifying-antirheumatic-drugs-in-rheumatoid-arthritis-multiparametric-analysis-integrating
#19
Nandigam Santosh Kumar, Yogesh Shejul, Ramesh Asopa, Sandip Basu
The purpose of this study was to assess the role of fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) in the evaluation of treatment response evaluation to disease-modifying antirheumatic drug (DMARD) therapy in patients of rheumatoid arthritis (RA). A total of ten patients with proven diagnosis of RA as per the 2010 American College of Rheumatology/European League against Rheumatism (EULAR) criteria were prospectively evaluated. All patients underwent clinical and biochemical evaluation and a baseline FDG-PET/CT with assessment of maximum standardized uptake value and metabolic volumetric product (MVP) values...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29032115/toll-like-receptor-4-tlr4-impairs-nitric-oxide-contributing-to-angiotensin-ii-induced-cavernosal-dysfunction
#20
Kenia P Nunes, Gisele F Bomfim, Haroldo A Toque, Theodora Szasz, R Clinton Webb
AIM: Angiotensin II (AngII), a corpus cavernosum (CC) constrictor peptide, modulates Toll like receptor (TLR) expression, a key element of the innate immune system, contributing to impaired vascular function in pathological conditions. However, it is unknown whether TLR4 is involved in AngII-induced erectile dysfunction. In this study, we investigated whether TLR4 plays a role in cavernosal dysfunction caused by AngII upregulation. MATERIAL AND METHODS: Cavernosal smooth muscle cells (CSMC) from C57/BL6 mice were treated with AngII (0...
October 12, 2017: Life Sciences
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