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Citrullinated peptides

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https://www.readbyqxmd.com/read/28100358/-study-on-the-effect-and-predictive-to-bronchiectasis-combined-with-rheumatoid-arthritis
#1
W Ding, Y F Zhao, H W Lu, S Liang, K B Cheng, J F Xu
Objective: To explore the clinical characteristics of bronchiectasis(BR)coexisting in patients with rheumatoid arthritis (RA). Methods: One hundred and forty-eight bronchiectasis patients were retrospectively analyzed. These cases were all diagnosed in the Respiratory Department of Shanghai Pulmonary Hospital and Shanghai Gongli Hospital of Pudong New Area during Jan. 2012 to Dec.2015.The patients consisted of 74 males and 74 females, aging from 45 to 79 [mean(65±11)] years. In these patients, coexisting rheumatoid arthritis was found in 34 males and 36 females, aging from 45 to 79[mean(68±12)] years(RA-BR group)...
January 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28099204/narrowing-in-on-the-anti-%C3%AE-cell-specific-t-cells-looking-where-the-action-is
#2
Sally C Kent, Jenny Aurielle B Babon
PURPOSE OF THE REVIEW: By necessity, the vast majority of information we have on autoreactive T cells in human type 1 diabetes (T1D) has come from the study of peripheral blood of donors with T1D. It is not clear how representative the peripheral autoreactive T-cell repertoire is of the autoreactive T cells infiltrating the islets in T1D. We will summarize and discuss what is known of the immunohistopathology of insulitis, the T-cell receptor repertoire expressed by islet-infiltrating T cells, and the autoreactivity and function of islet-infiltrating T cells in T1D...
January 17, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28079511/circulating-carotenoids-and-subsequent-risk-of-rheumatoid-arthritis-in-women
#3
Yang Hu, Jing Cui, Jeffrey A Sparks, Susan Malspeis, Karen H Costenbader, Elizabeth W Karlson, Bing Lu
OBJECTIVES: The aim of the present study was to examine the associations between circulating carotenoids and future risk of rheumatoid arthritis (RA). METHODS: We conducted a nested case-control study consisting of 227 incident RA cases and 671 matched controls with prospectively measured plasma carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene and lutein/zeaxanthin) levels in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II). Each incident RA case was matched with 3 healthy controls...
January 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28068286/pathobiochemical-mechanisms-relating-iron-homeostasis-to-parameters-of-inflammatory-activity-and-autoimmune-disorders-in-rheumatoid-arthritis
#4
Katya I Stefanova, Ginka T Delcheva, Ana I Maneva, Anastas Z Batalov, Mariela G Geneva-Popova, Rositza V Karalilova, Kiril K Simitchiev
AIM: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA). MATERIALS AND METHODS: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies, and DAS 28...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28053322/vav1-regulates-experimental-autoimmune-arthritis-and-is-associated-with-anti-ccp-negative-rheumatoid-arthritis
#5
A O Guerreiro-Cacais, U Norin, A Gyllenberg, R Berglund, A D Beyeen, E Petit-Teixeira, F Cornélis, A Saoudi, G J Fournié, R Holmdahl, L Alfredsson, L Klareskog, M Jagodic, T Olsson, I Kockum, L Padyukov
Rheumatoid arthritis (RA) patients can be stratified into two subgroups defined by the presence or absence of antibodies against citrullinated circular peptides (anti-CCP) with most of the genetic association found in anti-CCP positive RA. Here we addressed the role of VAV1, previously associated to multiple sclerosis (MS), in the pathogenesis of RA in experimental models and in a genetic association study. Experimental arthritis triggered by pristane or collagen type II was induced in DA rats and in the DA...
January 5, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28049385/anti-cyclic-citrullinated-glucose-6-phosphate-isomerase-peptide-7-ccg-7-antibodies-were-suppressed-by-biologics-treatment-and-deposited-to-citrullinated-proteins-in-cd68-positive-cells-in-the-ra-synovium
#6
Naoto Umeda, Isao Matsumoto, Yuki Tanaka, Hoshimi Kawaguchi, Hiroshi Ebe, Yayoi Kagami, Akihito Ishigami, Takayuki Sumida
No abstract text is available yet for this article.
January 4, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28029744/high-titer-rheumatoid-arthritis-antibodies-preferentially-bind-fibrinogen-citrullinated-by-peptidyl-arginine-deiminase-4
#7
Nathalie E Blachère, Salina Parveen, Mayu O Frank, Brian D Dill, Henrik Molina, Dana E Orange
OBJECTIVE: Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidyl arginine deiminase (PAD), PAD2 and PAD4, which catalyze citrullination with different substrate specificities, can be detected in RA synovium. This study was undertaken to determine whether RA patient antibodies preferentially bind PAD2 or PAD4 citrullinated fibrinogen. METHODS: RA patient and normal donor plasma was tested for binding to PAD2 or PAD4 citrullinated fibrinogen, native fibrinogen, or citrullinated fibrinogen peptides in various dilutions by ELISA and Western blot...
December 28, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28029071/predicting-citrullination-sites-in-protein-sequences-using-mrmr-method-and-random-forest-algorithm
#8
Qing Zhang, Xijun Sun, Kaiyan Feng, ShaoPeng Wang, Yu-Hang Zhang, SiBao Wang, Lin Lu, Yu-Dong Cai
As one of essential post-translational modifications (PTMs), the citrullination or deimination on an arginine residue would change the molecular weight and electrostatic charge of its side-chain. And it has been found that the citrullination in protein sequences was catalyzed by a type of Ca2+-dependent enzyme family called peptidylarginine deiminase (PAD), which include five isotypes: PAD1, 2, 3, 4/5, and 6. Citrullinated proteins participate in many biological processes, e.g. the citrullination of myelin basic protein (MBP) assists the early development of central nervous system...
December 27, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28002590/association-between-174g-c-and-572g-c-interleukin-6-gene-polymorphisms-and-severe-radiographic-damage-to-the-hands-of-mexican-patients-with-rheumatoid-arthritis-a-preliminary-report
#9
S A Zavaleta-Muñiz, L Gonzalez-Lopez, J D Murillo-Vazquez, A M Saldaña-Cruz, M L Vazquez-Villegas, B T Martín-Márquez, J C Vasquez-Jimenez, F Sandoval-Garcia, A J Ruiz-Padilla, N S Fajardo-Robledo, J M Ponce-Guarneros, A D Rocha-Muñoz, M F Alcaraz-Lopez, D Cardona-Müller, S E Totsuka-Sutto, E D Rubio-Arellano, J I Gamez-Nava
Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JBA). The objective of the present study was to evaluate the association between severe radiographic damage in hands and the -174G/C and -572G/C IL6 polymorphisms in Mexican Mestizo people with RA...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28002483/physical-characteristics-of-a-citrullinated-pro-filaggrin-epitope-recognized-by-anti-citrullinated-protein-antibodies-in-rheumatoid-arthritis-sera
#10
Nicole Hartwig Trier, Bettina Eide Holm, Ole Slot, Henning Locht, Hanne Lindegaard, Anders Svendsen, Gunnar Houen
Rheumatoid arthritis (RA) is an autoimmune disease of complex etiology. A characteristic feature of a subset of RA is the presence of anti-citrullinated protein antibodies (ACPA), which correlate with a progressive disease course. In this study, we employed streptavidin capture enzyme-linked immunosorbent assay to analyze ACPA reactivity. Using the pro-filaggrin peptide HQCHQEST-Cit-GRSRGRCGRSGS, as template, we analyzed the reactivity of RA sera and healthy donor sera to various peptides in order to determine the physical characteristics of the citrullinated pro-filaggrin epitope and to examine whether biotin labelling influence antibody recognition...
2016: PloS One
https://www.readbyqxmd.com/read/27994093/association-of-anti-citrullinated-protein-or-peptide-antibodies-with-left-ventricular-structure-and-function-in-rheumatoid-arthritis
#11
Laura Geraldino-Pardilla, Cesare Russo, Jeremy Sokolove, William H Robinson, Afshin Zartoshti, Jenny Van Eyk, Justyna Fert-Bober, Joao Lima, Jon T Giles, Joan M Bathon
OBJECTIVE: High levels of ACPAs in RA are associated with more severe arthritis and worse prognosis. However, the role of ACPAs in mediating the increased risk of heart failure in RA remains undefined. We examined whether specific ACPAs were associated with subclinical left ventricular (LV) phenotypes that presage heart failure. METHODS: Sera from RA patients without clinical cardiovascular disease were assayed for specific ACPAs using a custom Bio-Plex bead assay, and their cross-sectional associations with cardiac magnetic resonance-derived LV measures were evaluated...
December 19, 2016: Rheumatology
https://www.readbyqxmd.com/read/27987497/-significance-of-different-t-follicular-helper-subsets-in-rheumatoid-arthritis
#12
X M Chen, J Li, X Y Zhang, Y B Jin, D Yu, X L Sun, L J Wu, J He, Z G Li
OBJECTIVE: To detect the expressions of T follicular helper (Tfh) subsets and T follicular helper effect memory (Tfhem) cells in circulation of patients with rheumatoid arthritis (RA), as well as to examine their roles in providing biomarkers for active RA. METHODS: This study enrolled 41 patients with RA, who were navely-treated or had no application of hormone and disease-modifying anti-rheumatic drugs in recent 3 months, as well as 32 healthy controls. The percentages of Tfhem (CD4(+)CXCR5(+)CCR7(low)PD1(high)) cells, Tfh (CD3(+)CD4(+)CXCR5(+)CD45RA(-)) subsets, Tfh1 (CXCR3(+)CCR6(-)Tfh),Tfh2 (CXCR3(-)CCR6(-)Tfh),and Tfh17 (CXCR3(-)CCR6(+)Tfh), were determined by flow cytometry of peripheral blood from the patients with RA and health controls...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27987495/-significance-of-v-raf-murine-sarcoma-viral-oncogene-homologue-b1-in-rheumatoid-arthritis
#13
Y J Jin, L Sun, L Yang, R Xing, X Y Liu
OBJECTIVE: To detect serum v-raf murine sarcoma viral oncogene homologue B1 (BRAF) protein levels and to investigate their clinical significance in rheumatoid arthritis (RA) patients. METHODS: Serum samples were obtained from 78 RA patients, 32 osteoarthritis (OA) patients, 16 systemic lupus erythematosus (SLE) patients, 16 gout patients, 16 ankylosing spondylitis (AS) patients, 16 Sjogren syndrome (SS) patients and 30 healthy controls. BRAF protein in the sera was examined by enzyme-linked immunosorbent assay (ELISA)...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27987493/-significance-of-antibodies-to-the-citrullinated-glucose-6-phosphate-isomerase-peptides-in-rheumatoid-arthritis
#14
D Wu, L Sun, C H Li, L Yang, J X Zhao, X Y Liu
OBJECTIVE: To detect the anti-citrullinated glucose-6-phosphate isomerase (GPI) 70-88 peptide antibody(anti-C-GPI70-88 antibody),anti-citrullinated GPI 435-453 peptide antibody(anti-C-GPI435-453 antibody), anti-GPI 70-88 peptide antibody(anti-GPI70-88 antibody) and anti-GPI 435-453 peptide antibody(anti-GPI435-453 antibody) in the serum of rheumatoid arthritis(RA) patients,and examine the diagnostic values of the anti-C-GPI peptide antibodies in RA. METHODS: The anti-C-GPI70-88 antibody, anti-C-GPI435-453 antibody, anti-GPI70-88 antibody and anti-GPI435-453 antibody were detected by enzyme-linked immunosorbent assay (ELISA) in 191 RA patients, 129 other rheumatic diseases and 74 healthy controls...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27987492/-significance-and-diagnostic-value-of-synovial-fluid-anti-cyclic-citrullinated-peptide-antibody-and-anti-mutated-citrullinated-vimentin-antibodies-in-patients-with-serum-negative-rheumatoid-arthritis
#15
S J Qu, H Ye, R L Jia, Z G Li
OBJECTIVE: To explore the significance of synovial fluid (SF) anti-cyclic citrullinated peptide (CCP) antibodies and anti-mutated citrullinated vimentin (MCV) antibodies in the diagnosis of serum negative rheumatoid arthritis (SNRA). METHODS: Enzyme linked immunosorbent assay (ELISA) method was apllied in the detection of two groups of patients with knee joint fluid resistance against CCP antibody and antibody of MCV, the experimental group to SNRA patients, a total of 29 cases, and the control for patients with osteoarthritis (OA), a total of 28 cases, and clinical manifestations and laboratory parameters of the two groups were collected...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27975978/circular-disulfide-rich-peptide-scaffolds-as-anti-citrullinated-peptide-antibody-inhibitors
#16
S Gunasekera, C Fernandes-Cerqueira, C Eriksson, P J Jakobsson, U Göransson
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975947/synthesis-of-cyclic-citrullinated-peptides-targeting-rheumatoid-arthritis-autoantibodies-based-on-sunflower-trypsin-inhibitors
#17
C Eriksson, S Gunasekera, C Cerqueira, P J Jacobsson, U Göransson
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27966336/anticyclic-citrullinated-peptide-antibody-in-rheumatoid-arthritis-a-cross-sectional-study-in-iran
#18
Irandokht Shenavar Masooleh, Asghar Hajiabbasi, Habib Zayeni, Atefeh Ghanbari, Violet Zaker Esteghamati, Banafsheh Ghavidel Parsa, Amir Hassankhani
BACKGROUND/AIM: Studies have shown that anticyclic citrullinated peptide antibody (anti-CCP) titers can be useful in the diagnosis of rheumatoid arthritis (RA). We evaluate the association between anti-CCP antibody titers and the demographic, clinical, and laboratory characteristics of RA patients. Moreover, we explore whether there is any relation between joint destruction and demographic and clinical characteristics of RA patients. MATERIALS AND METHODS: One hundred and four RA patients with positive anti-CCP titers were compared to 104 RA patients with negative anti-CCP titers...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27964756/serum-il-33-a-new-marker-predicting-response-to-rituximab-in-rheumatoid-arthritis
#19
Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, Barbara Tolusso, Edward M Vital, Paul Emery, Gianfranco Ferraciolli, Martin Soubrier, Bineta Ly, Houria Hendel Chavez, Yassine Taoufik, Maxime Dougados, Xavier Mariette
BACKGROUND: Recent works have suggested a possible link between interleukin (IL)-33 and B-cell biology. We aimed to study the possible association between serum IL-33 detection and response to rituximab (RTX) in rheumatoid arthritis (RA) patients in different cohorts with an accurate enzyme-linked immunosorbent assay (ELISA). METHODS: Serum IL-33, rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), and high serum immunoglobulin (Ig)G levels were assessed in 111 RA patients receiving a first course of 2 g RTX (cohort 1) in an observational study and in 74 RA patients treated with the same schedule in routine care (cohort 2)...
December 13, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27958698/supramolecular-chemistry-assisted-electrochemical-method-for-the-assay-of-endogenous-peptidylarginine-deiminases-activities
#20
Jing Zhao, Lili Yang, Yingying Tang, Yucai Yang, Yongmei Yin
Peptidylarginine deiminase 4 (PAD4) is the only isoform of PADs located within the cell nucleus, which has been known to be related to several human diseases. In this work, we have proposed an electrochemical method for the assay of endogenous PAD4 activities as well as the studies of PAD4 inhibitors by making use of the supramolecular chemistry-assisted signal labeling. Specifically, peptide probes P1 and P2, which separately contain cysteine residues and tripeptides FGG (Phe-Gly-Gly), can be self-assembled onto the surface of the gold electrode and silver nanoparticles, respectively...
December 21, 2016: ACS Applied Materials & Interfaces
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