keyword
MENU ▼
Read by QxMD icon Read
search

Citrullinated peptides

keyword
https://www.readbyqxmd.com/read/29781829/comparison-of-adults-with-polyarticular-juvenile-idiopathic-arthritis-to-adults-with-rheumatoid-arthritis-a-cross-sectional-analysis-of-clinical-features-and-medication-use
#1
Danielle M Feger, Nicholas Longson, Hiranda Dodanwala, Barbara E Ostrov, Nancy J Olsen, Rayford R June
BACKGROUND/OBJECTIVE: Many individuals with juvenile idiopathic arthritis (JIA) have persistent disease into adulthood. Polyarticular JIA (pJIA) is often mislabeled as rheumatoid arthritis (RA) in adult rheumatology clinics, and treatment for adult pJIA patients is not well defined. We aimed to describe clinical features and medication use in the adult pJIA population in relation to an RA control cohort. METHODS: We performed a cross-sectional study of 45 adults with pJIA and 94 with RA seen from 2013 to 2017...
May 17, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29774784/moderate-alcohol-consumption-is-associated-with-increased-radiological-progression-in-women-but-not-in-men-with-early-rheumatoid-arthritis-results-from-the-espoir-cohort-%C3%A3-tude-et-suivi-des-polyarthrites-indiff%C3%A3-renci%C3%A3-es-r%C3%A3-centes
#2
F Sageloli, J L Quesada, B Fautrel, C Salliot, P Gaudin, A Baillet
OBJECTIVE: We conducted this study to determine whether alcohol consumption influences radiological progression in early rheumatoid arthritis (RA). METHOD: Patients fulfilling the European League Against Rheumatism/American College of Rheumatology 2010 criteria in the early arthritis cohort ESPOIR (Étude et Suivi des Polyarthrites Indifférenciées Récentes) were included in this study. Alcohol consumption was collected at baseline and at each visit. We classified alcohol consumption into three groups: abstinent (0 g/day), moderate (≤ 20 g/day for women, ≤ 30 g/day for men), and abuse (> 20 g/day for women, > 30 g/day for men)...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29756256/peptidylarginine-deiminases-and-deiminated-proteins-at-the-epidermal-barrier
#3
REVIEW
Laura Cau, Marie-Claire Méchin, Michel Simon
Deimination or citrullination is a posttranslational modification catalysed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs). It corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Deimination induces a decreased net charge of targeted proteins; therefore it alters their folding and changes intra and intermolecular ionic interactions. Deimination is involved in several physiological processes (inflammation, gene regulation, etc...
May 13, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29751523/annexin-a1-and-autoimmunity-from-basic-science-to-clinical-applications
#4
REVIEW
Maurizio Bruschi, Andrea Petretto, Augusto Vaglio, Laura Santucci, Giovanni Candiano, Gian Marco Ghiggeri
Annexin A1 is a protein with multifunctional roles in innate and adaptive immunity mainly devoted to the regulation of inflammatory cells and the resolution of inflammation. Most of the data regarding Annexin A1 roles in immunity derive from cell studies and from mice models lacking Annexin A1 for genetic manipulation (Annexin A1-/- ); only a few studies sought to define how Annexin A1 is involved in human diseases. High levels of anti-Annexin A1 autoantibodies have been reported in systemic lupus erythematosus (SLE), suggesting this protein is implicated in auto-immunity...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29735168/image-analysis-of-fibrosis-in-labial-salivary-glands-of-patients-with-systemic-autoimmune-diseases-close-correlation-of-lobular-fibrosis-to-seropositive-rheumatoid-arthritis-and-increased-anti-ccp-and-rf-titres-in-the-serum
#5
Krisztián Katona, Nelli Farkas, Mária Kneif, Gábor SütŐ, Tímea Berki, Balázs Balatonyi, Tamás Tornóczky
Lobular fibrosis in labial salivary glands of patients with systemic autoimmune disease is a rarely examined and rather neglected histological change. Its significance and disease association is poorly understood. Our aim was to explore the clinical correlations of fibrosis in labial salivary gland samples using objective methods and laboratory parameters. Labial salivary gland samples from more than 300 patients over a 3-year period were selected from the archives of the pathology department, histologically examined, digitised, image analysed and statistically evaluated to identify the presence and intensity of lobular fibrosis, its relation to age, clinical diagnoses of systemic autoimmune disease and the presence of rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP), antinuclear antibodies (ANAs), and anti-dsDNA serum markers...
May 4, 2018: Pathology
https://www.readbyqxmd.com/read/29724731/exposure-to-passive-smoking-and-rheumatoid-arthritis-risk-results-from-the-swedish-eira-study
#6
Anna Karin Hedström, Lars Klareskog, Lars Alfredsson
INTRODUCTION: Smoking has consistently been associated with increased risk of developing rheumatoid arthritis (RA). The aim of this study was to estimate the influence of passive smoking on the risk of developing anti-cyclic citrullinated peptide antibodies (ACPA)-positive and ACPA-negative RA. METHODS: A population-based case-control study using incident cases of RA was performed in Sweden, and the study population in this report was restricted to include never-smokers (589 cases, 1764 controls)...
May 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29720260/smoking-body-mass-index-disease-activity-and-the-risk-of-rapid-radiographic-progression-in-patients-with-early-rheumatoid-arthritis
#7
Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T H Jacobsson, Carl Turesson
BACKGROUND: Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characteristics and subsequent rapid radiographic progression (RRP). METHODS: An inception cohort of patients with early RA (symptom duration < 12 months), recruited during 1995-2005 from a defined area (Malmö, Sweden), was investigated...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29701040/-clinical-therapeutic-effects-on-rheumatoid-arthritis-treated-with-the-assisted-therapy-of-acupuncture-at-the-points-detected-with-thermosensitive-moxibustion-in-zhuang-medicine
#8
An Huang, Yuzhou Pang, Qianqian Tang, Jing Xu, Jiyong Lin, Jianying Li
OBJECTIVE: To evaluate the clinical therapeutic effects and safety on rheumatoid arthritis (RA) treated with acupuncture at the points detected with thermosensitive moxibustion in Zhuang medicine combined with western medication. METHODS: A total of 168 RA patients in compliance with the inclusive criteria were collected and randomized into an observation group and a control group, 84 cases in each one. In the control group, in reference to the updated guideline of new drugs by the European League Against Rheumatism (EULAR) in 2013, the medication scheme was formulated for oral administration, methotrexate tablet 7...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29686987/recognition-and-relevance-of-anti-dfs70-autoantibodies-in-routine-antinuclear-autoantibodies-testing-at-a-community-hospital
#9
John B Carter, Sara Carter, Sandra Saschenbrecker, Bruce E Goeckeritz
Antinuclear autoantibodies (ANA) displaying a dense fine speckled pattern (DFS, ICAP AC-2) on HEp-2 cells are frequently observed in clinical laboratory referrals, often associated with anti-DFS70 specificity. Anti-DFS70 positive patients rarely develop systemic autoimmune rheumatic disease (SARD), especially in the absence of clinical evidence or additional anti-extractable nuclear antigen (ENA) antibodies, prompting suggestions that an isolated DFS70-specific ENA may be an exclusionary finding for SARD. In this study, the frequency and diagnostic significance of anti-DFS70 autoantibodies was investigated in a community hospital cohort of patients undergoing routine ANA testing...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29683356/is-current-smoking-status-and-its-relationship-to-anti-cyclic-citrullinated-peptide-antibodies-a-predictor-of-worse-response-to-biological-therapies-in-rheumatoid-arthritis-patients
#10
V Torrente-Segarra, S A Bergstra, K Salomon-Escoto, Jap Da Silva, D J Veale, S Al-Emadi, Twj Huizinga
OBJECTIVE: To assess the association between smoking, anti-cyclic citrullinated peptide (anti-CCP) antibody status, and clinical efficacy of biological therapies in rheumatoid arthritis (RA) patients. METHOD: This retrospective clinical practice setting study included 1349 RA patients from the METEOR database (aged >18 years). We collected data on sociodemographics, smoking status (smoker, <10, 10-19, and >20 cigarettes/day; ex-smoker; non-smoker), baseline disease activity parameters and anti-CCP, previous disease-modifying anti-rheumatic drugs (DMARDs), biological therapy, combined therapy (steroids and DMARDs), and follow-up disease activity...
April 23, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29668445/pathobiochemical-mechanisms-relating-iron-homeostasis-with-parameters-of-inflammatory-activity-and-autoimmune-disorders-in-rheumatoid-arthritis
#11
Katya I Stefanova, Ginka T Delcheva, Ana I Maneva, Anastas Z Batalov, Mariela G Geneva-Popova, Rositza V Karalilova, Kiril K Simitchiev
AIM: To find the correlations between the parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA). MATERIALS AND METHODS: The present study included 114 patients with RA and 42 healthy controls. We determined the parameters of iron homeostasis: serum iron, total iron binding capacity (TIBC), ferritin and soluble transferrin receptor (sTfR), the parameters of inflammatory activity: C-reactive protein (CRP), interleukin-6 (IL-6) and prohepcidin, and the parameters of autoimmune disorders: rheumatoid factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies and DAS 28...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29651025/cardiac-eccentric-remodeling-in-patients-with-rheumatoid-arthritis
#12
Valeria Pascale, Rosa Finelli, Rocco Giannotti, Enrico Coscioni, Raffaele Izzo, Francesco Rozza, Dario Caputo, Paolo Moscato, Guido Iaccarino, Michele Ciccarelli
It is known that patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease and sudden cardiac death. Abnormalities in cardiac geometry appear to be involved in the setting of the cardiovascular risk, but it has never been specifically investigated in RA. We enrolled 44 patients with RA compared to 131 subjects without RA (normal, N): The RA aged between 18 and 70 years (mean 48.3 ± 2.1), 25 females, BMI 27.6 ± 0.9; N, of equal age (48.6 ± 1.2, n.s.), included 80 females (BMI 26...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29624881/study-on-association-of-human-leukocyte-antigen-drb1-alleles-in-rheumatoid-arthritis-within-bangladeshi-population
#13
Maksuma Begum, Humayun Sattar, Syed A Haq, Md Nazrul Islam, Sushanta K Saha, M Masudul Hassan, Ritu Saha, Md Shahriar Kabir
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic and autoimmune disease affecting 0.5-1% of the world population. Genetic and environmental factors are already established as being involved in the development of RA. Different human leukocyte antigen (HLA)-DRB1 alleles have major pathogenic effects to the development of RA. OBJECTIVE: To determine the HLA-DRB1 allelic frequency of RA in one Bangladeshi tertiary care center. METHODS: This case-control study was conducted at the Microbiology and Rheumatology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU)...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29624625/clinical-management-of-seronegative-and-seropositive-rheumatoid-arthritis-a-comparative-study
#14
Sang-Tae Choi, Kwang-Hoon Lee
Both rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) are associated with poor radiologic outcomes in patients with rheumatoid arthritis (RA). In general, RA patients positive for RF or ACPA (SPRA) are considered to manifest an aggressive disease course compared with seronegative RA patients (SNRA). However, the relationship between seropositivity and measures of disease severity other than radiologic outcome is disputed. In this study, we sought to compare the clinical presentations and treatment outcomes of SNRA and SPRA patients...
2018: PloS One
https://www.readbyqxmd.com/read/29610271/mining-the-human-tissue-proteome-for-protein-citrullination
#15
Chien-Yun Lee, Dongxue Wang, Mathias Wilhelm, Daniel Paul Zolg, Tobias Schmidt, Karsten Schnatbaum, Ulf Reimer, Fredrik Pontén, Mathias Uhlén, Hannes Hahne, Bernhard Kuster
Citrullination is a post-translational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations and while the modification has been linked to several diseases including rheumatoid arthritis and cancer, its physiological or pathophysiological roles remain largely unclear. In part this is owing to limitations in available methodology able to robustly enrich, detect and localize the modification. As a result, only few citrullination sites have been identified on human proteins with high confidence...
April 2, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29606664/rheumatoid-arthritis-magnetic-resonance-imaging-score-predicts-therapy-response-results-of-the-german-arthromark-cohort
#16
Philipp Sewerin, Lien Le, Stefan Vordenbäumen, Christoph Schleich, Ruben Sengewein, Ralph Brinks, Georg Pongratz, Ellen Bleck, Juliane Lesch, Ulrich Mansmann, Matthias Schneider, Benedikt Ostendorf
OBJECTIVE: Markers for treatment response in rheumatoid arthritis (RA) are lacking. The aim of the study was to assess the performance of the RA magnetic resonance imaging (MRI) scoring system (RAMRIS) in combination with serum biomarkers to predict response to methotrexate (MTX) treatment in therapy-naive patients with early RA by using high-field MRI. METHODS: Twenty-eight patients with RA were prospectively assessed with baseline 3-T MRI of the clinical dominant hand, 3 and 6 months after MTX...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29584756/transcriptional-signature-associated-with-early-rheumatoid-arthritis-and-healthy-individuals-at-high-risk-to-develop-the-disease
#17
N Macías-Segura, J E Castañeda-Delgado, Y Bastian, D Santiago-Algarra, J D Castillo-Ortiz, A L Alemán-Navarro, E Jaime-Sánchez, M Gomez-Moreno, C A Saucedo-Toral, Edgar E Lara-Ramírez, M Zapata-Zuñiga, L Enciso-Moreno, R González-Amaro, C Ramos-Remus, J A Enciso-Moreno
BACKGROUND: Little is known regarding the mechanisms underlying the loss of tolerance in the early and preclinical stages of autoimmune diseases. The aim of this work was to identify the transcriptional profile and signaling pathways associated to non-treated early rheumatoid arthritis (RA) and subjects at high risk. Several biomarker candidates for early RA are proposed. METHODS: Whole blood total RNA was obtained from non-treated early RA patients with <1 year of evolution as well as from healthy first-degree relatives of patients with RA (FDR) classified as ACCP+ and ACCP- according to their antibodies serum levels against cyclic citrullinated peptides...
2018: PloS One
https://www.readbyqxmd.com/read/29581384/ultrasound-is-more-reliable-than-inflammatory-parameters-to-evaluate-disease-activity-in-patients-with-ra-receiving-tocilizumab-therapy
#18
Wen-Chan Chiu, Han-Ming Lai, Chi-Hua Ko, Jia-Feng Chen, Chung-Yuan Hsu, Ying-Chou Chen
The target of treatment for rheumatoid arthritis (RA) is to keep low disease activity or remission. Tocilizumab can fully inhibit interleukin-6 and C reactive protein (CRP) production. The goal of the study is to search whether tocilizumab treatment compared with adalimumab treatment had the similar effect on sonography and inflammatory parameters in patients with RA. We compared ultrasound scores and inflammatory parameters between patients with RA receiving tocilizumab therapy and those receiving adalimumab therapy...
March 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29575159/mapping-the-tandem-mass-spectrometric-characteristics-of-citrulline-containing-peptides
#19
Arnold Steckel, Katalin Uray, Lilla Turiák, Ágnes Gömöry, László Drahos, Ferenc Hudecz, Gitta Schlosser
RATIONALE: Protein citrullination (deimination) is a post-translational modification of proteins converting arginine(s) to citrulline(s). "Overcitrullination" could be associated with severe pathological conditions. Mass spectrometric analysis of modified proteins is hindered by several problems. A comprehensive study of fragmentation of deiminated peptides is not yet available. In this paper we have made an attempt to describe the characteristics of these processes, based on the studies of epitope model oligopeptides derived from clinically relevant proteins...
March 25, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29565828/a-metabolomics-approach-uncovers-differences-between-traditional-and-commercial-dairy-products-in-buryatia-russian-federation
#20
Lin Pan, Jie Yu, Zhihui Mi, Lanxin Mo, Hao Jin, Caiqing Yao, Dongyan Ren, Bilige Menghe
Commercially available and traditional dairy products differ in terms of their manufacturing processes. In this study, commercially available and traditionally fermented cheese, yogurt, and milk beverages were analyzed and compared. The metabolomic technique of ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry (UPLC-Q-TOF) in the MSE mode was used in combination with statistical methods, including univariate analysis and chemometric analysis, to determine the differences in metabolite profiles between commercially and traditionally fermented dairy products...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
5687
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"