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https://www.readbyqxmd.com/read/29317955/pattern-of-thyroid-lesions-in-western-region-of-saudi-arabia-a-retrospective-analysis-and-literature-review
#1
Muhammad I Saeed, Amal Ali Hassan, Muhammad Ejaz Butt, Khalid Ali Baniyaseen, Muhammad I Siddiqui, Neda M Bogari, Faisal A Al-Allaf, Mohiuddin M Taher
Background: Ultrasonography (US) is being recognized as a traditional way of the diagnosis of various thyroid disorders, and this will help in detecting the thyroid tumors in early stage. Thyroid nodules are common and usually benign; steps to diagnose malignancy should include a careful clinical evaluation, laboratory tests, a thyroid US exam and a fine-needle aspiration (FNA) biopsy. Methods: A total of 173 registered cases were used for analysis in this study...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29317372/pancreas-ductal-adenocarcinoma-with-cystic-features-on-cross-sectional-imaging-radiologic-pathologic-correlation
#2
Seo Yeon Youn, Sung Eun Rha, Eun Sun Jung, In Seok Lee
Most pancreatic ductal adenocarcinomas (PDAs) show solid growth pattern, but ductal adenocarcinomas may demonstrate intratumoral cystic appearance or accompany peritumoral non-neoplastic cystic lesions, thus mimicking cystic pancreatic tumors on imaging studies. The histopathologic findings for PDA with cystic feature are divided into neoplastic and non-neoplastic cysts. Neoplastic cystic changes include large-duct type cysts (microcystic appearance), neoplastic mucin cysts (macrocystic appearance), colloid carcinomas (mucinous noncystic adenocarcinomas), and degenerative cystic change usually caused by hemorrhagic necrosis of tumor...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29297488/mucinous-and-secondary-tumors-of-the-prostate
#3
Adeboye O Osunkoya
Primary mucinous tumors and secondary tumors involving the prostate gland are relatively uncommon, however they have important diagnostic, therapeutic, and prognostic implications. The primary mucinous tumors of the prostate include mucinous (colloid) adenocarcinoma of the prostate, prostatic adenocarcinoma with mucinous features, and mucinous adenocarcinoma of the prostatic urethra (mucin-producing urothelial-type adenocarcinoma of the prostate). Mucinous adenocarcinoma of the prostate is defined as a primary prostatic acinar tumor characterized by the presence of at least 25% of the tumor composed of glands with extraluminal mucin...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29285861/biliary-versus-thyroid-like-a-tale-of-two-morphologies
#4
Sharon J Song, Kathleen Montone, Kristen Stashek, Rashmi Tondon
Pictured here is a portacaval lymph node biopsy from a 72-year-old man with an 11.9 cm liver mass and several enlarged surrounding lymph nodes. The node was involved by a tumor with two distinct morphologies-one area resembling a primary pancreaticobiliary tumor (Figure 1) and another mimicking a thyroid follicular carcinoma with microfollicles containing brightly eosinophilic, colloid-like secretions (Figure 2). Immunohistochemistry showed the neoplastic cells to stain strongly with CK7 and CK19, with patchy positivity for CK20...
December 28, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29251639/mammary-analog-secretory-carcinoma-with-etv6-rearrangement-arising-in-the-conjunctiva-and-eyelid
#5
Yongyang Bao, Jiang Li, Yanbo Zhu
Mammary analog secretory carcinoma (MASC) of salivary gland is a recently described neoplasm that morphologically and immunohistochemically resembles secretory carcinoma of the breast. Genetically, both of them harbor ETV-6-NTRK-3 fusion rearrangement. One case of primary MASCs arising from the eyelid is reported. The patient was a 52-year-old man. Microscopically, the tumor exhibited nodular aggregation of solid, tubular, and microcystic/macrocystic structures. Characteristic "colloid-like" eosinophilic secretory material was present within intraluminal spaces...
November 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29242877/unravelling-the-mechanisms-that-determine-the-uptake-and-metabolism-of-magnetic-single-and-multicore-nanoparticles-in-a-xenopus-laevis-model
#6
M Marín-Barba, H Gavilán, L Gutiérrez, E Lozano-Velasco, I Rodríguez-Ramiro, G N Wheeler, C J Morris, M P Morales, A Ruiz
Multicore superparamagnetic nanoparticles have been proposed as ideal tools for some biomedical applications because of their high magnetic moment per particle, high specific surface area and long term colloidal stability. Through controlled aggregation and packing of magnetic cores it is possible to obtain not only single-core but also multicore and hollow spheres with internal voids. In this work, we compare toxicological properties of single and multicore nanoparticles. Both types of particles showed moderate in vitro toxicity (MTT assay) tested in Hep G2 (human hepatocellular carcinoma) and Caco-2 (human colorectal adenocarcinoma) cells...
December 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/29230133/invasive-insular-thyroid-carcinoma-presenting-as-nonparalytic-dysphonia
#7
Blake S Raggio, Blair M Barton, Maria C Grant, Judith A Fornadley, Jeffrey P Marino
Background: Patients with suspected thyroid malignancy often undergo preoperative laryngeal examination with a focus on vocal fold mobility. We present the unique case of a patient with invasive thyroid carcinoma who presented with dysphonia despite intact vocal fold motion. Case Report: A 73-year-old female with a remote thyroid lobectomy presented with dysphonia. Thyroid ultrasound and fine-needle aspiration revealed a 1.1-cm nodule consistent with a colloid cyst...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29193962/cell-penetrating-polymers-containing-guanidinium-trigger-apoptosis-in-human-hepatocellular-carcinoma-cells-unless-conjugated-to-a-targeting-n-acetyl-galactosamine-block
#8
Zhe Tan, Yogesh K Dhande, Theresa M Reineke
A series of 3-guanidinopropyl methacrylamide (GPMA)-based polymeric gene delivery vehicles were developed via aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymers have been evaluated for their cellular internalization ability, transfection efficiency, and cytotoxicity. Two homopolymers: P(GPMA20), P(GPMA34), were synthesized to study the effect of guanidium polymer length on delivery efficiency and toxicity. In addition, an N-acetyl-d-galactosamine (GalNAc)-based hydrophilic block was incorporated to produce diblock polymers, which provides a neutral hydrophilic block that sterically protects plasmid-polymer complexes (polyplexes) from colloidal aggregation and aids polyplex targeting to hepatocytes via binding to asialoglycoprotein receptors (ASGPRs)...
December 1, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29169620/pancreatic-colloid-carcinoma-in-an-elderly-cat
#9
K Hagiwara, M Michishita, H Yoshimura, K Ochiai, D Azakami, T Ishiwata, K Takahashi
A 21-year-old neutered female domestic shorthaired cat was presented with a history of inappetence, vomiting and haematuria. The cat was humanely destroyed at the owner's request and a necropsy examination was performed. A 0.8 × 0.5 × 0.5 cm mass was located in the left lobe of the pancreas. The mass was gelatinous in nature and the external and cut surfaces were pale yellow in colour. Microscopically, the mass was non-capsulated and comprised an accumulation of extracellular stromal mucin containing suspended neoplastic columnar epithelial cells forming tubular structures...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29152431/intensity-modulated-proton-therapy-with-advanced-planning-techniques-in-a-challenging-hepatocellular-carcinoma-patient
#10
Smith Apisarnthanarax, Jatinder Saini, Avril O'Ryan-Blair, Jackie Castro, Stephen R Bowen
The use of radiation therapy has been increasing over recent years for the treatment of hepatocellular carcinoma (HCC). Proton beam therapy (PBT) has emerged as a promising treatment option for HCC patients due to its dosimetric advantages of sparing more normal liver tissue from radiation at low to moderate doses compared to photon-based treatments while still delivering high doses of radiation to tumors. The PBT therapy may be particularly beneficial in high-risk HCC cirrhotic patients with large, bulky tumors and/or vascular invasion complicated by surrounding perfusion abnormalities...
September 10, 2017: Curēus
https://www.readbyqxmd.com/read/29074635/patterns-of-sonographically-detectable-echogenic-foci-in-pediatric-thyroid-carcinoma-with-corresponding-histopathology-an-observational-study
#11
I Erdem Toslak, B Martin, G A Barkan, A I Kılıç, J E Lim-Dunham
BACKGROUND AND PURPOSE: Small echogenic foci within pediatric thyroid nodules are commonly seen by ultrasound and are one of the features used to determine the level of suspicion for malignancy. These are sometimes termed "microcalcifications," but their relation with malignancy is controversial due to the lack of standard terminology. Our aim was to evaluate sonographic patterns of echogenic foci in malignant pediatric thyroid nodules and describe the distribution of corresponding psammoma bodies and other histopathologic findings in thyroidectomy specimens...
October 26, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29067394/a-simple-neridronate-based-surface-coating-strategy-for-upconversion-nanoparticles-highly-colloidally-stable-125-i-radiolabeled-nayf4-yb-3-er-3-peg-nanoparticles-for-multimodal-in-vivo-tissue-imaging
#12
Uliana Kostiv, Volodymyr Lobaz, Jan Kučka, Pavel Švec, Ondřej Sedláček, Martin Hrubý, Olga Janoušková, Pavla Francová, Věra Kolářová, Luděk Šefc, Daniel Horák
In this report, monodisperse upconversion NaYF4:Yb(3+)/Er(3+) nanoparticles with superior optical properties were synthesized by the oleic acid-stabilized high-temperature co-precipitation of lanthanide chlorides in octadec-1-ene as a high-boiling organic solvent. To render the particles with biocompatibility and colloidal stability in bioanalytically relevant phosphate buffered saline (PBS), they were modified by using in-house synthesized poly(ethylene glycol)-neridronate (PEG-Ner), a bisphosponate. The NaYF4:Yb(3+)/Er(3+)@PEG nanoparticles showed excellent long-term stability in PBS and/or albumin without any aggregation or morphology transformation...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29047068/intraductal-papillary-mucinous-neoplasm-of-the-pancreas-in-young-patients-tumor-biology-clinical-features-and-survival-outcomes
#13
Vicente Morales-Oyarvide, Mari Mino-Kenudson, Cristina R Ferrone, Andrew L Warshaw, Keith D Lillemoe, Dushyant V Sahani, Ilaria Pergolini, Marc A Attiyeh, Mohammad Al Efishat, Neda Rezaee, Ralph H Hruban, Jin He, Matthew J Weiss, Peter J Allen, Christopher L Wolfgang, Carlos Fernández-Del Castillo
AIM: The aim of this paper is to describe the characteristics of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in young patients. METHODS: We evaluated 1693 patients from the Pancreatic Surgery Consortium who underwent resection for IPMN and classified them as younger or older than 50 years of age at the time of surgery. We assessed the relationship of age with clinical, radiological, pathological, and prognostic features. RESULTS: We identified 90 (5%) young patients...
October 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29030129/laryngeal-and-vocal-alterations-after-thyroidectomy
#14
Renata Mizusaki Iyomasa, José Vicente Tagliarini, Sérgio Augusto Rodrigues, Elaine Lara Mendes Tavares, Regina Helena Garcia Martins
INTRODUCTION: Dysphonia is a common symptom after thyroidectomy. OBJECTIVE: To analyze the vocal symptoms, auditory-perceptual and acoustic vocal, videolaryngoscopy, the surgical procedures and histopathological findings in patients undergoing thyroidectomy. METHODS: Prospective study. Patients submitted to thyroidectomy were evaluated as follows: anamnesis, laryngoscopy, and acoustic vocal assessments. Moments: pre-operative, 1st post (15 days), 2nd post (1 month), 3rd post (3 months), and 4th post (6 months)...
September 21, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29028127/pure-mucinous-colloid-adenocarcinoma-of-the-conjunctiva
#15
Valentina Logunova, Olayemi Sokumbi
Primary mucinous carcinomas of the periorbital region are very rare and often require differential diagnosis of metastatic disease. We describe a case of pure mucinous adenocarcinoma arising in the subconjunctival stroma of the ocular fornix in a female patient with a longstanding history of bilateral ocular cicatricial pemphigoid. Histologically, the tumor was composed of predominantly goblet-like cells floating in pools of mucin separated by delicate collagenous septa. The initial suspicion was of primary cutaneous mucinous carcinoma and less likely endocrine mucin-producing sweat gland carcinoma, however the CK7-/synaptophysin-/chromogranin-immunoprofile did not confirm either of the two...
January 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28962799/engineering-pectin-based-hollow-nanocapsules-for-delivery-of-anticancer-drug
#16
Feng Ji, Junjie Li, Zhihui Qin, Boguang Yang, Ershuai Zhang, Dianyu Dong, Jinmei Wang, Yan Wen, Liang Tian, Fanglian Yao
Multifunctional capsules have great applications in biomedical fields. In this study, novel polysaccharide-based nanocapsules were prepared via a layer-by-layer technique using silica as the templates. The shell was constructed based on the electrostatic interactions between pectin and chitosan. The pectin-chitosan nanocapsules ((Pec/Cs)3Pec) could keep good colloidal stability within 96h in PBS solution and 48h in BSA solution. Meanwhile, the nanocapsules exhibited a high drug loading and pH-sensitive release property for doxorubicin hydrochloride...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917533/nanoparticles-of-a-polyaspartamide-based-brush-copolymer-for-modified-release-of-sorafenib-in-vitro-and-in-vivo-evaluation
#17
Melchiorre Cervello, Giovanna Pitarresi, Antonella Bavuso Volpe, Barbara Porsio, Daniele Balasus, Maria Rita Emma, Antonina Azzolina, Roberto Puleio, Guido Ruggero Loria, Stefano Puleo, Gaetano Giammona
In this paper, we describe the preparation of polymeric nanoparticles (NPs) loaded with sorafenib for the treatment of hepatocellular carcinoma (HCC). A synthetic brush copolymer, named PHEA-BIB-ButMA (PBB), was synthesized by Atom Trasnfer Radical Polymerization (ATRP) starting from the α-poly(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) and poly butyl methacrylate (ButMA). Empty and sorafenib loaded PBB NPs were, then, produced by using a dialysis method and showed spherical morphology, colloidal size, negative ζ potential and the ability to allow a sustained sorafenib release in physiological environment...
September 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28890154/diabetes-mellitus-in-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-is-associated-with-high-grade-dysplasia-and-invasive-carcinoma
#18
Vicente Morales-Oyarvide, Mari Mino-Kenudson, Cristina R Ferrone, Dushyant V Sahani, Ilaria Pergolini, Adrián A Negreros-Osuna, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo
BACKGROUND: While the association between Diabetes Mellitus (DM) and pancreatic ductal adenocarcinoma is well recognized, its importance in intraductal papillary mucinous neoplasm of the pancreas (IPMN) is not well-defined. We sought to examine the associations of DM with degree of dysplasia and morphological subtypes in IPMN. METHODS: In 454 patients with resected IPMN, we evaluated associations of DM with high-grade dysplasia (HGD), invasive carcinoma, precursor epithelial subtype (gastric, intestinal, oncocytic, pancreatobiliary), and histological type of invasive carcinomas (tubular, colloid, oncocytic) using logistic regression...
September 7, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28764174/an-indian-tertiary-care-hospital-scenario-of-papillary-carcinoma-of-thyroid
#19
Ponnuswamy Karkuzhali, Muthureddy Yogambal, Manoj Kumar
INTRODUCTION: Thyroid carcinoma is the most common endocrine malignancy and its Papillary Histotype {Papillary Carcinoma of Thyroid (PTC)} is the most common type of Thyroid cancer. The clinicopathological features of PTC vary with geographical location. AIM: To describe the clinicopathological profile of PTC in a Tertiary Care Hospital located in Chennai, Tamil Nadu, India. MATERIALS AND METHODS: Data on age, sex, centricity of the tumour, presence of calcifications, infiltration, metastasis, associated non malignant conditions and frequency of histological subtypes of all cases of PTC diagnosed in Department of Pathology, Madras Medical College Chennai, Tamil Nadu, India between January 2007 and December 2011 were obtained from clinicopathological documents and analysed statistically...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28726368/mussel-inspired-polydopamine-coated-lanthanide-nanoparticles-for-nir-ii-ct-dual-imaging-and-photothermal-therapy
#20
Yu Dai, Dongpeng Yang, Danping Yu, Cong Cao, Qiuhong Wang, Songhai Xie, Liang Shen, Wei Feng, Fuyou Li
Nanomedicine has attracted substantial attention for the accurate diagnosis or treatment of carcinoma in recent years. Nd(3+)-doped lanthanide nanophosphor-based near-infrared-II (NIR-II) optical imaging is widely used for deep penetration tissue imaging while X-ray computed tomography (CT) is well-suited for in vivo imaging. Polymer-coated lanthanide nanophosphors are increasingly used in both diagnostics and therapies for tumor in vivo. However, the biocompatibility of nanocomposites and the efficiency of tumor ablation should be taken into consideration when constructing a nanotheranostic probe...
August 16, 2017: ACS Applied Materials & Interfaces
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