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Epothilones spinal cord injury

Jörg Ruschel, Farida Hellal, Kevin C Flynn, Sebastian Dupraz, David A Elliott, Andrea Tedeschi, Margaret Bates, Christopher Sliwinski, Gary Brook, Kristina Dobrindt, Michael Peitz, Oliver Brüstle, Michael D Norenberg, Armin Blesch, Norbert Weidner, Mary Bartlett Bunge, John L Bixby, Frank Bradke
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the cellular mechanisms of this dual effect remain unclear. Here, delayed systemic administration of a blood-brain barrier-permeable microtubule-stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abrogating polarization and directed migration of scar-forming fibroblasts...
April 17, 2015: Science
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