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Epothilones spinal cord injury

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https://www.readbyqxmd.com/read/29095439/epothilone-b-impairs-functional-recovery-after-spinal-cord-injury-by-increasing-secretion-of-macrophage-colony-stimulating-factor
#1
Liang Mao, Wei Gao, Shurui Chen, Ying Song, Changwei Song, Zipeng Zhou, Haosen Zhao, Kang Zhou, Wei Wang, Kunming Zhu, Chang Liu, Xifan Mei
The microtubule-stabilizing drug epothilone B (epoB) has shown potential value in the treatment of spinal cord injury (SCI) through diverse mechanisms. However, it remains elusive why a limited overall effect was observed. We aim to investigate the limiting factors underlying functional recovery promoted by epoB. The same SCI model treated by epoB was established as discussed previously. We used a cerebrospinal fluid (CSF) sample to assess the changes in cytokines in milieu of the SCI lesion site after epoB treatment...
November 2, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28469665/mechanisms-responsible-for-the-inhibitory-effects-of-epothilone-b-on-scar-formation-after-spinal-cord-injury
#2
Wei Zhao, Yong Chai, Yun Hou, Da-Wei Wang, Jian-Qiang Xing, Cheng Yang, Qing-Min Fang
Scar formation after spinal cord injury is regarded as an obstacle to axonal regeneration and functional recovery. Epothilone B provides moderate microtubule stabilization and is mainly used for anti-tumor therapy. It also reduces scar tissue formation and promotes axonal regeneration after spinal cord injury. The aim of the present study was to investigate the effect and mechanism of the microtubule-stabilizing reagent epothilone B in decreasing fibrotic scarring through its action on pericytes after spinal cord injury...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28444817/microtubule-stabilization-promoted-axonal-regeneration-and-functional-recovery-after-spinal-root-avulsion
#3
Heng Li, Wutian Wu
A spinal root avulsion injury disconnects spinal roots with the spinal cord. The rampant motoneuron death, inhibitory CNS/PNS transitional zone (TZ) for axonal regrowth and limited regeneration speed together lead to motor dysfunction. Microtubules rearrange to assemble a new growth cone and disorganized microtubules underline regeneration failure. It has been shown that microtubule-stabilizing drug, Epothilone B, enhanced axonal regeneration and attenuated fibrotic scaring after spinal cord injury. Here, we are reporting that after spinal root avulsion+ re-implantation in adult rats, EpoB treatment improved motor functional recovery and potentiated electrical responses of motor units...
April 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27872763/effects-of-microtubule-stabilization-by-epothilone-b-depend-on-the-type-and-age-of-neurons
#4
Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur
Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/25765066/axonal-regeneration-systemic-administration-of-epothilone-b-promotes-axon-regeneration-after-spinal-cord-injury
#5
Jörg Ruschel, Farida Hellal, Kevin C Flynn, Sebastian Dupraz, David A Elliott, Andrea Tedeschi, Margaret Bates, Christopher Sliwinski, Gary Brook, Kristina Dobrindt, Michael Peitz, Oliver Brüstle, Michael D Norenberg, Armin Blesch, Norbert Weidner, Mary Bartlett Bunge, John L Bixby, Frank Bradke
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the cellular mechanisms of this dual effect remain unclear. Here, delayed systemic administration of a blood-brain barrier-permeable microtubule-stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abrogating polarization and directed migration of scar-forming fibroblasts...
April 17, 2015: Science
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