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Epothilones spinal cord injury

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https://www.readbyqxmd.com/read/27872763/effects-of-microtubule-stabilization-by-epothilone-b-depend-on-the-type-and-age-of-neurons
#1
Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur
Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/25765066/axonal-regeneration-systemic-administration-of-epothilone-b-promotes-axon-regeneration-after-spinal-cord-injury
#2
Jörg Ruschel, Farida Hellal, Kevin C Flynn, Sebastian Dupraz, David A Elliott, Andrea Tedeschi, Margaret Bates, Christopher Sliwinski, Gary Brook, Kristina Dobrindt, Michael Peitz, Oliver Brüstle, Michael D Norenberg, Armin Blesch, Norbert Weidner, Mary Bartlett Bunge, John L Bixby, Frank Bradke
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the cellular mechanisms of this dual effect remain unclear. Here, delayed systemic administration of a blood-brain barrier-permeable microtubule-stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abrogating polarization and directed migration of scar-forming fibroblasts...
April 17, 2015: Science
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