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Haploidentical stem cell transplantation

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https://www.readbyqxmd.com/read/29680516/peripheral-blood-grafts-for-t-cell-replete-haploidentical-transplantation-increase-the-incidence-and-severity-of-cytokine-release-syndrome
#1
Renju V Raj, Mehdi Hamadani, Aniko Szabo, Marcelo C Pasquini, Nirav N Shah, William R Drobyski, Bronwen E Shaw, Wael Saber, J Douglas Rizzo, James Jerkins, Timothy S Fenske, Anita D'Souza, Binod Dhakal, Chao Zhang, Steve Konings, Parameswaran N Hari, Saurabh Chhabra
T-cell replete post-transplant cyclophosphamide (PT-CY)-based protocols have led to increasing use of haploidentical allogeneic hematopoietic cell transplantation (haploHCT). With this approach, bidirectional alloreactivity causing non-engraftment or severe graft-versus-host disease (GVHD) are no longer major barriers to haploHCT. PT-CY eliminates alloreactive lymphocytes but spares CD34+ stem cells and regulatory T lymphocytes, resulting in reliable hematopoietic recovery with relatively low incidence of GVHD...
April 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29677078/therapeutic-outcomes-of-haploidentical-allogeneic-hematopoietic-stem-cell-transplantation-in-patients-with-severe-aplastic-anemia-a-multicenter-study
#2
Yonghua Li, Fengqi Duan, Haowen Xiao, Xiaoxiong Wu, Shunqing Wang, Duorong Xu, Qifa Liu, Zhiping Fan, Danian Nie, Yongrong Lai, Bingyi Wu, Dongjun Lin, Xin Du, Jianyu Weng, Xin Du, Zujun Jiang, Yan Pang, Lin Ouyang, Zenghui Liu, Leqin Zhang, Na Han, Lixuan Chen, Yang Xiao
BACKGROUND: Haploidentical donor allogeneic hematopoietic stem cell transplantation (HID-HSCT) is an alternative curative treatment for patients with severe aplastic anemia (SAA) who do not have suitable matched related donors (MRD). The aim of this study was to compare the therapeutic outcomes of HID-HSCT with those of MRD-HSCT for SAA. METHODS: A total of 235 SAA patients who underwent HID-HSCT (116) or MRD-HSCT (119) at 11 transplantation centers from January 2007 to January 2016 were included...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29675688/everyone-has-a-donor-contribution-of-the-chinese-experience-to-global-practice-of-haploidentical-hematopoietic-stem-cell-transplantation
#3
REVIEW
Meng Lv, Yingjun Chang, Xiaojun Huang
Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management...
April 19, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29665928/-clinical-characteristics-treatment-and-prognosis-of-ptld-after-allogeneic-hematopoietic-stem-cell-transplantation
#4
Zhan-Xiang Liu, Wen-Rong Huang, Meng Li, Zhen-Yang Gu, Cheng-Ying Zhu, Ning Lu, Sheng Yao, Shu-Hong Wang, Fei Li, Xiao-Ning Gao, Dai-Hong Liu, Chun-Ji Gao
OBJECTIVE: To study the clinical characteristics of patients with post-transplantation lymphoproliferative disease (PTLD) after allogeneic peripheral blood hematopoietic stem cell transplantation, and to improve the understanding and diagnosis of PTLD. METHODS: The clinical data of 244 patients underwent allogeneic hematopoietic stem cell transplantation in the General Hospital of PLA from May 2014 to April 2017 were analyzed retrospectively. The follow-up time was up to November 30, 2017...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665923/-the-effect-of-serum-cytokine-levels-prior-transplantation-on-the-outcome-of-severe-aplastic-anemia-patients-received-allogeneic-hematopoietic-stem-cell-transplantation
#5
Zhao Wang, Yuan-Yuan Shi, Xin Yang, Su-Dong Zhang, Li-Ning Zhang, Dong-Lin Yang, Yi He, Rong-Li Zhang, Er-Lie Jiang, Jia-Lin Wei, Si-Zhou Feng, Min-Zhe Han
OBJECTIVE: To identify the role of serum cytokine levels prior allogeneic hematopoietic stem cell trans-plantation (allo-HSCT) in the outcome of severe aplastic anemia (SAA) patients received allo-HSCT treatment. METHODS: The clinical data of 117 SAA patients received allo-HSCT were enrolled in this study. The overall survival (OS), graft versus host disease (GVHD) incidence and relationship of serum cytokines with OS and major transplantation complications were retrospectively analyzed...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29663666/comparison-of-outcomes-after-hla-matched-unrelated-and-%C3%AE-%C3%AE-t-cell-depleted-haploidentical-hematopoietic-stem-cell-transplantation-for-children-with-high-risk-acute-leukemia
#6
Fatih Erbey, Arzu Akçay, Didem Atay, Ercüment Ovalı, Gülyüz Öztürk
T-cell-depleted HAPLO HSCT is an option to treat children with high-risk acute leukemia lacking an HLA-identical donor. We reviewed the outcome of children with acute leukemia after HAPLO (n = 21) and HLA-MUD (n = 32) transplantation. The proportion of patients with ≥CR2 was significantly higher in HAPLO transplantation than MUD transplantation. Patients with MUD transplantation were significantly higher ABO incompatible than patients with HAPLO transplantation. There was no difference between the 2 groups in terms of engraftment, aGvHD and cGvHD, VOD, hemorrhagic cystitis, infections, and relapse...
April 16, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29661468/successful-treatment-of-cytogenetically-normal-acute-myeloid-leukemia-with-ten-eleven-translocation-2-isocitrate-dehydrogenase-2-and-additional-sex-comb-like-1-nucleophosmin-co-mutations-by-hla-haploidentical-stem-cell-transplantation-a-case-report-and-literature
#7
Y Liu, Y Cao, Y Lin, W-M Dong, R-R Lin, Q Gu, X-B Xie, W-Y Gu
The presence of recurrent gene mutations is increasingly important in acute myeloid leukemia (AML) and sheds new insights into the understanding of leukemogenesis, prognostic evaluation, and clinical therapeutic efficacy. Until now, ten-eleven translocation 2 (TET2) and isocitrate dehydrogenase 2 (IDH2) mutations were reported to be mutually exclusive in AML patients. Similarly, nucleophosmin (NPM1) and additional sex comb-like 1 (ASXL1) mutations were rarely coexisted in AML. A 47-year-old man diagnosed with high-risk AML presented simultaneous mutations of TET2-IDH2 and NPM1-ASXL1 revealed by next-generation sequencing...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661208/unmanipulated-haploidentical-in-comparison-with-matched-unrelated-donor-stem-cell-transplantation-in-patients-60-years-and-older-with-acute-myeloid-leukemia-a-comparative-study-on-behalf-of-the-alwp-of-the-ebmt
#8
Nicole Santoro, Myriam Labopin, Federica Giannotti, Gerard Ehninger, Dietger Niederwieser, Arne Brecht, Matthias Stelljes, Nicolaus Kröger, Herman Einsele, Matthias Eder, Michael Hallek, Bertram Glass, Jürgen Finke, Fabio Ciceri, Mohamad Mohty, Annalisa Ruggeri, Arnon Nagler
BACKGROUND: Acute myeloid leukemia (AML) is both more common and with more biologically aggressive phenotype in the elderly. Allogenic stem cell transplantation (allo-SCT) is the best treatment option in fit patients. Either HLA-matched unrelated donor (MUD) or haploidentical (Haplo) donor are possible alternative for patients in need. METHODS: We retrospectively compared non-T-cell-depleted Haplo (n = 250) to 10/10 MUD (n = 2589) in AML patients ≥ 60 years...
April 16, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29656137/haploidentical-peripheral-blood-stem-cell-transplantation-demonstrates-stable-engraftment-in-adults-with-sickle-cell-disease
#9
Santosh L Saraf, Annie L Oh, Pritesh R Patel, Karen Sweiss, Matthew Koshy, Sally Campbell-Lee, Michel Gowhari, Shivi Jain, David Peace, John G Quigley, Irum Khan, Robert E Molokie, Nadim Mahmud, Victor R Gordeuk, Damiano Rondelli
We report on the screening and development of haploidentical hematopoietic stem cell transplantation (HSCT) for adult patients with clinically aggressive sickle cell disease (SCD) at our institution. Of 50 adult SCD patients referred for HSCT between 1/2014-3/2017, 20% were denied by insurance. Of 41 patients initially screened, 10% lacked an available haploidentical donor, 29% had elevated donor specific antibodies (DSA) and 34% declined to proceed to HSCT. All 10 patients who were transplanted received peripheral blood stem cells (PBSC)...
April 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29649752/which-donor-is-better-when-a-matched-donor-is-not-available-domestically-comparison-of-outcomes-of-allogeneic-stem-cell-transplantation-with-haploidentical-and-international-donors-in-a-homogenous-ethnic-population
#10
Hyunkyung Park, Yoo Jin Lee, Sang-Jin Shin, Jayoun Lee, Silvia Park, Inho Kim, Joon-Ho Moon, Hyewon Lee, Jun Ho Jang, Sung-Soo Yoon, Youngil Koh
A substantial proportion of patients requiring allogeneic stem cell transplantation (alloSCT) do not have a human leukocyte antigen-matched sibling donor and need an alternative donor. In this multicenter retrospective study, we compared the outcomes of 176 patients with myelodysplastic syndrome and acute leukemia undergoing alloSCT from haploidentical (n = 121) and international (n = 55) donors between 2002 and 2016. For recipients of haploidentical and international donors, the 2-year overall survival rates were 33...
April 4, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29579887/donor-selection-based-on-killer-cell-immunoglobulin-like-receptor-kir-genotype-may-improve-outcome-after-t-cell-replete-haploidentical-transplantation
#11
A Torío, M J Pascual, I Vidales, M Ortiz, A Caballero, A I Heiniger
BACKGROUND: In haploidentical stem cell transplantation (SCT), the "ideal donor" selection is not performed in a standardized way according to killer cell immunoglobulin-like receptor (KIR) genotype expressed by potential donors. The aim of this study was to evaluate the relevance of KIR genotype in a series of patients submitted to haploidentical SCT in our center. METHODS: We retrospectively analyzed 30 patients that were prepared with the use of a conditioning regimen including thiotepa-busulfan-fludarabine with high doses of post-transplantation cyclophosphamide (CyPT) and tacrolimus as graft-versus-host disease (GVHD) prophylaxis...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29578122/efficacy-and-safety-of-unmanipulated-haploidentical-related-donor-allogeneic-peripheral-blood-stem-cell-transplantation-in-patients-with-relapsed-refractory-acute-myeloid-leukemia
#12
Li-Ping Dou, Hong-Hua Li, Lu Wang, Fei Li, Wen-Rong Huang, Li Yu, Dai-Hong Liu
Background: Studies of haploidentical-related donor (HRD) stem cell transplantation using a combination of peripheral blood stem cells (PBSCs) and bone marrow as the graft have reported encouraging results for patients with hematological diseases. However, few studies specifically reported transplantation of only PBSCs from HRDs among patients with relapsed or refractory acute myeloid leukemia (AML). Here, the long-term outcomes and side effects of unmanipulated HRD PBSC transplantation (HRD-PBSCT) for relapsed/refractory AML were analyzed...
April 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29568992/igg-synthesis-rate-and-anti-myelin-oligodendrocyte-glycoprotein-antibody-in-csf-may-be-associated-with-the-onset-of-cns-demyelination-after-haplo-hsct
#13
Xiao-Hui Zhang, Xin Zhao, Chen-Cong Wang, Wei Han, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yuan-Yuan Zhang, Xiao-Dong Mo, Yao Chen, Yu Wang, Hai-Xia Fu, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang
Haploidentical hematopoietic stem cell transplant (haplo-HSCT) is an upfront and effective therapy for hematology patients, but it usually has many complications, such as neurological complications. As one of the neurological complications following haplo-HSCT, immune-mediated demyelinating diseases of the central nervous system (CNS) seriously affect a patient's quality of life. However, the incidence, risk factors, and pathogenesis of CNS demyelination are not very well understood. Thirty of the 1526 patients (1...
March 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29562462/-effects-of-preexisting-donor-specific-hla-antibodies-for-graft-failure-in-un-manipulated-haploidentical-hematopoietic-stem-cell-transplantation
#14
R L Zhang, X H Zheng, L K Zhou, Y Zhang, S L Chen, D L Yang, E L Jiang, J L Wei, Y Huang, Q L Ma, W H Zhai, S Z Feng, M Z Han, Y He
Objective: To investigate the effects of donor-specific HLA antibodies(DSA) for graft failure in un-manipulated haploidentical hematopoietic stem cell transplantation(haplo-HSCT) and the feasible treatment for DSA. Methods: HLA antibodies were examined using the Luminex-based single Ag assay for 92 patients who were going on haplo-SCT and the correlations of graft failure and DSA among the patients who had finished SCT were analyzed. Results: Of the total 92 patients who were going on haplo-HSCT, sixteen (17...
March 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29562461/-comparison-of-different-styles-of-allogeneic-hematopoietic-stem-cell-transplantation-as-first-line-treatment-treated-with-severe-aplastic-anemia-in-children-and-adolescents
#15
S W Yang, R J Ma, J J Zhao, H F Zhong, X L Yuan, L Jiang, J Yang, P C Lei, Y Zhang, Y W Fu, D M Wan, Z M Zhu
Objective: To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from different donors as first-line treatment for children and adolescents with severe aplastic anemia (SAA) . Methods: The clinical data of 79 children and adolescents with SAA diagnosed from January 2013 to December 2016 in Henan Province were retrospectively analyzed. There were 50 males and 29 females, with a median age of 14(4-18) years. 40 cases received matched sibling transplantation (MSD-HSCT), 17 with unrelated donor transplantation (UD-HSCT), and 22 with haploidentical transplantation (haplo-HSCT)...
March 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29556955/adult-stem-cells-and-medicine
#16
Sinem Civriz Bozdağ, Meltem Kurt Yüksel, Taner Demirer
Stem cells can be either totipotent, pluripotent, multipotent or unipotent. Totipotent cells have the capability to produce all cell types of the developing organism, including both embryonic and extraembryonic tissues. The Hematopoietic Stem Cells (HSC) are the first defined adult stem cells (ASC) that give rise to all blood cells and immune system. Use of HSCs for treatment of hematologic malignancies, which is also called bone marrow (BM) transplantation or peripheral blood stem cells (PBSC) transplantation is the pioneer of cellular therapy and translational research...
March 20, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29550630/conditioning-regimen-with-plerixafor-is-safe-and-improves-the-outcome-of-tcr%C3%AE-%C3%AE-and-cd19-cell-depleted-stem-cell-transplantation-in-wiskott-aldrich-syndrome-patients
#17
Dmitry Balashov, Alexandra Laberko, Anna Shcherbina, Pavel Trakhtman, Dmitrii Abramov, Elena Gutovskaya, Svetlana Kozlovskaya, Larisa Shelikhova, Galina Novichkova, Michael Maschan, Alexander Rumiantsev, Alexei Maschan
Our initial experience of hematopoietic stem cell transplantation (HSCT) from a matched unrelated donor (MUD; n=12) or a haploidentical related donor (n=6) with TCRαβ+/CD19+ graft depletion for Wiskott-Aldrich syndrome (WAS) patients (n=18) showed a dramatic decrease in the incidence of graft-versus-host disease (GVHD) and transplant-related mortality, with an increased rate of overall survival (OS) of 88,9%. Unfortunately, the treatment was associated with mixed myeloid donor chimerism and secondary graft dysfunction (severe thrombocytopenia, n=2; graft rejection, n=5)...
March 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29542029/clofarabine-followed-by-haploidentical-stem-cell-transplant-using-fludarabine-busulfan-and-total-body-irradiation-with-post-transplant-cyclophosphamide-in-non-remission-aml
#18
Kevin Rakszawski, Kosuke Miki, David Claxton, Henry Wagner, Hiroko Shike, Shin Mineishi, Seema Naik
Approximately 30-40% of patients with acute myeloid leukemia (AML) experience induction failures. In these patients who do not achieve remission with two cycles of standard induction therapies, the probability of achieving remission with subsequent inductions is very limited. Hematopoietic stem cell transplantation (HSCT) is the only curative option for these patients, but high relapse rate and transplant-related mortality often preclude them to proceed to transplant. Thus, AML not in remission at time of HSCT remains a huge unmet need in current HSCT practice, particularly if the patient does not have an HLA-matched donor identified by the time of two induction failures...
March 14, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29532539/co-transplantation-of-haploidentical-hematopoietic-stem-cell-and-allogeneic-bone-marrow-derived-mesenchymal-stromal-cells-as-a-first-line-treatment-in-very-severe-aplastic-anemia-patients-with-refractory-infections
#19
Chunyan Yue, Yingying Ding, Yang Gao, Li Li, Yan Pang, Zenghui Liu, Hang Zhang, Yang Xiao, Zujun Jiang, Haowen Xiao
OBJECTIVES: In patients with very severe aplastic anemia (VSAA), neutropenia is prolonged and persistent, resulting in refractory overwhelming infections. Hematopoiesis recovery is urgently needed. METHODS: Six patients with de novo VSAA lacking HLA-identical sibling donors and those who experienced refractory infections, underwent haploidentical related donor (HRD) hematopoietic stem cell transplantation (HSCT) as a first-line therapy. The conditioning regimen consisted of busulfan, cyclophosphamide and rabbit antithymocyte globulin...
March 12, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29523885/cost-effectiveness-analysis-of-haploidentical-vs-matched-unrelated-allogeneic-hematopoietic-stem-cells-transplantation-in-patients-older-than-55-years
#20
Mathias Debals-Gonthier, Carole Siani, Catherine Faucher, Rajae Touzani, Claude Lemarié-Basset, Christian Chabannon, Sabine Furst, Raynier Devillier, Samia Harbi, Luca Castagna, Laurence Caymaris, Didier Blaise, Anne-Gaëlle Le Corroller Soriano
Due to limited donor availability, high comorbidities, and cost issues, allogeneic hematopoietic stem cell transplant is not universally accessible. The aim of this study was to conduct a cost-effectiveness analysis of haploidentical vs matched unrelated transplant. This retrospective study included patients with hematological malignancies older than 55 years who underwent haploidentical or matched unrelated transplant between 2011 and 2013 in Marseille. The incremental cost-effectiveness ratio has been calculated using the mean overall survival and the mean transplant costs...
March 9, 2018: Bone Marrow Transplantation
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