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Biomedical hiv prevention

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https://www.readbyqxmd.com/read/29770060/setting-the-stage-for-expanding-hiv-pre-exposure-prophylaxis-use-in-canada
#1
EDITORIAL
M Hull, Dhs Tan
Human immunodeficiency virus (HIV) infection continues to disproportionately affect vulnerable populations in Canada; particularly men who have sex with men (MSM). Novel HIV prevention strategies have recently expanded from the use of non-occupational post-exposure prophylaxis (nPEP) after high risk exposures to the use of pre-exposure prophylaxis (PrEP) in which individuals reduce risk of HIV infection through use of combination antiretrovirals taken prior to risk exposure. With approval of tenofovir/emtricitabine (TDF/FTC) for use as PrEP only in early 2016, and with limited public funding to date, uptake in Canada is in its preliminary stages...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29758049/user-evaluations-offer-promise-for-pod-intravaginal-ring-as-a-drug-delivery-platform-a-mixed-methods-study-of-acceptability-and-use-experiences
#2
Kate M Guthrie, Rochelle K Rosen, Sara E Vargas, Melissa L Getz, Lauren Dawson, Melissa Guillen, Jaime J Ramirez, Marc M Baum, Kathleen L Vincent
BACKGROUND: Effective HIV prevention requires efficient delivery of safe and efficacious drugs and optimization of user adherence. The user's experiences with the drug, delivery system, and use parameters are critical to product acceptability and adherence. Prevention product developers have the opportunity to directly control a drug delivery system and its impact on acceptability and adherence, as well as product efficacy. Involvement of potential users during preclinical design and development can facilitate this process...
2018: PloS One
https://www.readbyqxmd.com/read/29736816/pre-exposure-prophylaxis-for-hiv-infection-in-the-older-patient-what-can-be-recommended
#3
Iacopo Franconi, Giovanni Guaraldi
Over the past 15 years, a significant increase in new HIV/AIDS diagnoses has been observed in the elderly population. This new epidemiological shift has been attributed to a longer sex life, lifestyle and changes in sexual behavior, poor sexual health education, and misconceptions about the absence of sexually transmitted disease in later life. Although many biomedical and behavioral interventions have proven useful to prevent sexually transmitted infections and HIV, pre-exposure prophylaxis (PrEP) has been shown to be the most successful biomedical intervention to prevent HIV in high-risk individuals...
May 8, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29725192/african-american-clergy-perspectives-about-the-hiv-care-continuum-results-from-a-qualitative-study-in-jackson-mississippi
#4
Amy Nunn, Sharon Parker, Katryna McCoy, Mauda Monger, Melverta Bender, Joanna Poceta, Julia Harvey, Gladys Thomas, Kendra Johnson, Yusuf Ransome, Cassandra Sutten Coats, Phil Chan, Leandro Mena
Mississippi has some of the most pronounced racial disparities in HIV infection in the country; African Americans comprised 37% of the Mississippi population but represented 80% of new HIV cases in 2015. Improving outcomes along the HIV care continuum, including linking and retaining more individuals and enhancing adherence to medication, may reduce the disparities faced by African Americans in Mississippi. Little is understood about clergy's views about the HIV care continuum. We assessed knowledge of African American pastors and ministers in Jackson, Mississippi about HIV and the HIV care continuum...
2018: Ethnicity & Disease
https://www.readbyqxmd.com/read/29695201/systematic-review-of-barriers-and-facilitators-to-voluntary-medical-male-circumcision-in-priority-countries-and-programmatic-implications-for-service-uptake
#5
Maria A Carrasco, Jessica Wilkinson, Benjamin Kasdan, Paul Fleming
Voluntary medical male circumcision (VMMC) is an effective biomedical HIV prevention strategy. There is a need to identify key barriers and facilitators to VMMC uptake in priority countries to improve uptake. In this paper, we report findings from a systematic review of the barriers and facilitators of VMMC uptake, comparing them across countries in order to provide programmers critical information to design effective VMMC uptake interventions. Our review followed PRISMA protocol. Twenty three articles from 10 of the 14 priority countries were included...
April 26, 2018: Global Public Health
https://www.readbyqxmd.com/read/29684131/the-somatic-marker-hypothesis-and-sexual-decision-making-understanding-the-role-of-iowa-gambling-task-performance-and-daily-sexual-arousal-on-the-sexual-behavior-of-gay-and-bisexual-men
#6
H Jonathon Rendina, Brett M Millar, Genevieve Dash, Sarah W Feldstein Ewing, Jeffrey T Parsons
Background: The sexual decision-making literature suggests that sexual arousal and behavior are associated. The somatic marker hypothesis suggests that individual neuropsychological differences in decision making, as measured by the Iowa Gambling Task (IGT), may moderate these associations; however, this hypothesis has yet to be tested with event-level sexual behavior data. Purpose: We hypothesized that (a) daily sexual arousal would be positively associated with likelihood of engaging in sex and condomless anal sex (CAS) and (b) IGT scores would moderate these associations such that the associations would be stronger among those with higher IGT scores...
April 19, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29666937/biomedical-approaches-to-hiv-prevention-in-women
#7
REVIEW
Christine L Heumann
PURPOSE OF REVIEW: Effective HIV prevention techniques for women are of critical importance, as nearly half of all HIV infections globally are in women. This article reviews the recent literature on biomedical approaches to HIV prevention in women. RECENT FINDINGS: In trials in which women were adherent to oral pre-exposure prophylaxis (PrEP), PrEP was equally efficacious in men and women. However, in studies of oral PrEP exclusively in women, adherence was low, and it was not efficacious...
April 17, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29622045/a-couple-based-hiv-prevention-intervention-for-latino-men-who-have-sex-with-men-study-protocol-for-a-randomized-controlled-trial
#8
Omar Martinez, M Isabel Fernandez, Elwin Wu, Alex Carballo-Diéguez, Guillermo Prado, Adam Davey, Ethan Levine, Brian Mattera, Nikki Lopez, Omar Valentin, Ashley Murray, Madeline Sutton
BACKGROUND: Latino men who have sex with men (MSM) experienced a 13% increase in HIV diagnoses from 2010 to 2014, more than any other racial/ethnic subgroup of MSM in the United States. If current HIV diagnoses rates persist, about one in four Latino MSM in the United States will be diagnosed with HIV during their lifetime. Although some efficacious HIV prevention interventions for Latino MSM exist, none have focused on couples. This paper describes the protocol of a randomized controlled trial (RCT) to test the preliminary efficacy of a couple-based HIV prevention intervention that is culturally tailored for Latino men and their same-sex partners...
April 5, 2018: Trials
https://www.readbyqxmd.com/read/29594094/navigating-multiple-sources-of-healing-in-the-context-of-hiv-aids-and-wide-availability-of-antiretroviral-treatment-a-qualitative-study-of-community-participants-perceptions-and-experiences-in-rural-south-africa
#9
Thembelihle Zuma, Daniel Wight, Tamsen Rochat, Mosa Moshabela
Background: South Africa introduced the world's largest antiretroviral treatment (ART) program in 2004 and since 2016 the Department of Health implemented a universal Treatment as Prevention (TasP) strategy. However, some studies have shown that increasing the availability of ART is insufficient for the comprehensive treatment of HIV, since many people still use traditional health practitioners (THPs) to avoid being identified as HIV positive, and for reasons unrelated to HIV/AIDS. This qualitative study explored the factors influencing how both HIV-negative and HIV-positive people choose amongst multiple sources of healing and how they engage with them, in the context of HIV/AIDS and wide availability of ART...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29584769/development-of-a-repeat-exposure-penile-shiv-infection-model-in-macaques-to-evaluate-biomedical-preventions-against-hiv
#10
David A Garber, James Mitchell, Debra Adams, Patricia Guenthner, Frank Deyounks, Shanon Ellis, Kristen Kelley, Ryan Johnson, Charles Dobard, Walid Heneine, Janet McNicholl
Penile acquisition of HIV infection contributes substantially to the global epidemic. Our goal was to establish a preclinical macaque model of penile HIV infection for evaluating the efficacy of new HIV prevention modalities. Rhesus macaques were challenged once or twice weekly with consistent doses of SHIVsf162P3 (a chimeric simian-human immunodeficiency virus containing HIV env) ranging from 4-600 TCID50 (50% tissue culture infective dose), via two penile routes, until systemic SHIV infection was confirmed...
2018: PloS One
https://www.readbyqxmd.com/read/29550942/prevalence-of-and-factors-associated-with-the-use-of-hiv-serosorting-and-other-biomedical-prevention-strategies-among-men-who-have-sex-with-men-in-a-us-nationwide-survey
#11
Christian Grov, H Jonathan Rendina, Viraj V Patel, Elizabeth Kelvin, Kathryn Anastos, Jeffrey T Parsons
PrEP and treatment-as-prevention (TasP) are biomedical strategies to reduce HIV transmission. Some men who have sex with men (MSM) are combining biomedical strategies with HIV serosorting-termed "biomed matching" when both partners are either on PrEP or TasP, or "biomed sorting" when one partner is using PrEP and the other TasP. Nevertheless, there is limited data on the extent of biomed matching/sorting in large geographically diverse samples. In 2016-2017, 5021 MSM from across the US were surveyed about their HIV status and HIV viral load/PrEP use, as well as that of their recent casual male partners...
March 17, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29541273/protection-efficacy-of-c5a-against-vaginal-and-rectal-hiv-challenges-in-humanized-mice
#12
Philippe A Gallay, Udayan Chatterji, Aaron Kirchhoff, Angel Gandarilla, Richard B Pyles, Marc M Baum, John A Moss
Introduction: In the absence of a vaccine, there is an urgent need for the identification of effective agents that prevent HIV transmission in uninfected individuals. Non-vaccine Biomedical Prevention (nBP) methods, such as topical or systemic pre-exposure prophylaxis (PrEP), are promising strategies to slow down the spread of AIDS. Methods: In this study, we investigated the microbicidal efficacy of the viral membrane-disrupting amphipathic SWLRDIWDWICEVLSDFK peptide called C5A...
2018: Open Virology Journal
https://www.readbyqxmd.com/read/29538626/a-randomized-clinical-trial-of-a-brief-internet-based-group-intervention-to-reduce-sexual-transmission-risk-behavior-among-hiv-positive-gay-and-bisexual-men
#13
Dean G Cruess, Kaylee E Burnham, David J Finitsis, Brett M Goshe, Lauren Strainge, Moira Kalichman, Tamar Grebler, Chauncey Cherry, Seth C Kalichman
Background: HIV disproportionately affects sexual minority men, and developing strategies to reduce transmission risk is a public health priority. Purpose: The goal was to empirically test a newly developed, Information, Motivation, Behavioral skills (IMB) theoretically derived, online HIV sexual risk reduction intervention (called HINTS) among a sample of sexual minority men living with HIV. Methods: Participants were 167 men randomized to either the four-session online HINTS intervention or to a time-matched, online control condition...
February 5, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29528850/adolescent-lives-matter-preventing-hiv-in-adolescents
#14
Audrey Pettifor, Marie Stoner, Carey Pike, Linda-Gail Bekker
PURPOSE OF REVIEW: Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be curtailed. This review examines the most effective prevention approaches to reach these adolescent populations in the next 5 years. RECENT FINDINGS: Adolescents are in transition and are developmentally unique...
May 2018: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29513719/the-role-of-agency-in-the-implementation-of-isoniazid-preventive-therapy-ipt-lessons-from-omakoti-in-umgungundlovu-district-south-africa
#15
Jody Boffa, Maria Mayan, Sithembile Ndlovu, Tsholofelo Mhlaba, Tyler Williamson, Reginald Sauve, Dina Fisher
INTRODUCTION: In response to revisions in global and national policy in 2011, six-month isoniazid preventive therapy (IPT) became freely available as a preventive measure for people living with HIV in the uMgungundlovu District of KwaZulu-Natal province, South Africa. Given a difference in uptake and completion by sex, we sought to explore the reasons why Zulu women were more likely to accept and complete IPT compared to men in an effort to inform future implementation. METHODS: Utilising a community-based participatory research approach and ethnographic methods, we undertook 17 individual and group interviews, and met regularly with grassroots community advisory teams in three Zulu communities located in uMgungundlovu District between March 2012-December 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29490665/south-south-collaboration-on-hiv-aids-prevention-and-treatment-research-when-birds-of-a-feather-rarely-flock-together
#16
Bruna de Paula Fonseca E Fonseca, Priscila Costa Albuquerque, Ed Noyons, Fabio Zicker
BACKGROUND: South-south collaboration on health and development research is a critical mechanism for social and economic progress. It allows sharing and replicating experiences to find a "southern solution" to meet shared health challenges, such as access to adequate HIV/AIDS prevention and treatment. This study aimed to generate evidence on the dynamics of south-south collaboration in HIV/AIDS research, which could ultimately inform stakeholders on the progress and nature of collaboration towards increased research capacities in low- and middle-income countries (LMIC)...
March 1, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29461979/tandem-bispecific-neutralizing-antibody-eliminates-hiv-1-infection-in-humanized-mice
#17
Xilin Wu, Jia Guo, Mengyue Niu, Minghui An, Li Liu, Hui Wang, Xia Jin, Qi Zhang, Ka Shing Lam, Tongjin Wu, Hua Wang, Qian Wang, Yanhua Du, Jingjing Li, Lin Cheng, Hang Ying Tang, Hong Shang, Linqi Zhang, Paul Zhou, Zhiwei Chen
The discovery of an HIV-1 cure remains a medical challenge because the virus rebounds quickly after the cessation of combination antiretroviral therapy (cART). Here, we investigate the potential of an engineered tandem bispecific broadly neutralizing antibody (bs-bnAb) as an innovative product for HIV-1 prophylactic and therapeutic interventions. We discovered that by preserving 2 single-chain variable fragment (scFv) binding domains of each parental bnAb, a single gene-encoded tandem bs-bnAb, BiIA-SG, displayed substantially improved breadth and potency...
April 23, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29460740/ending-the-hiv-aids-pandemic-1
#18
Robert Walter Eisinger, Anthony S Fauci
The goal of ending the HIV/AIDS pandemic is theoretically achievable and would require addressing this global health catastrophe on individual and global levels by providing optimal prevention strategies and treatment regimens for individual persons living with or at risk for HIV, as well as ending the pandemic as an epidemiologic and global health phenomenon. However, from a practical standpoint, the pathway to ending the HIV/AIDS pandemic will be difficult and will require aggressive implementation of the biomedical research advances that have been made in the areas of treatment and prevention; development of additional tools, such as a moderately effective HIV vaccine; and attention to critical behavioral and social determinants...
March 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29444997/efficacy-of-multicomponent-culturally-tailored-hiv-sti-prevention-interventions-targeting-foreign-female-entertainment-workers-a-quasi-experimental-trial
#19
Raymond B T Lim, Olive N Y Cheung, Bee Choo Tai, Mark I-C Chen, Roy K W Chan, Mee Lian Wong
OBJECTIVES: We assessed the efficacy of a multicomponent culturally tailored HIV/STI prevention intervention programme on consistent condom use and STI incidence among foreign Thai and Vietnamese female entertainment workers (FEWs) in Singapore. METHODS: We conducted a quasi-experimental pretest and post-test intervention trial with a comparison group. We recruited 220 participants (115 Vietnamese and 105 Thai) for the comparison group, followed by the intervention group (same number) from the same sites which were purposively selected after a 3-month interval period...
February 14, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29420549/contexts-of-vulnerability-and-the-acceptability-of-new-biomedical-hiv-prevention-technologies-among-key-populations-in-south-africa-a-qualitative-study
#20
Millicent Atujuna, Peter A Newman, Melissa Wallace, Megan Eluhu, Clara Rubincam, Ben Brown, Linda-Gail Bekker
BACKGROUND: New biomedical prevention technologies (NPTs) may contribute to substantially reducing incident HIV infections globally. We explored acceptability and preferences for NPTs among key and other vulnerable populations in two South African townships. METHODS: We conducted six focus groups and 12 in-depth interviews with adolescents, and adult heterosexual men, women, and men who have sex with men (MSM) (n = 48), and eight in-depth interviews with key informant healthcare workers...
2018: PloS One
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