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Biomedical hiv prevention

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https://www.readbyqxmd.com/read/28214391/correlates-of-willingness-to-initiate-pre-exposure-prophylaxis-and-anticipation-of-practicing-safer-drug-and-sex-related-behaviors-among-high-risk-drug-users-on-methadone-treatment
#1
Roman Shrestha, Pramila Karki, Frederick L Altice, Tania B Huedo-Medina, Jaimie P Meyer, Lynn Madden, Michael Copenhaver
BACKGROUND: Although people who use drugs (PWUD) are key populations recommended to receive pre-exposure prophylaxis (PrEP) to prevent HIV, few data are available to guide PrEP delivery in this underserved group. We therefore examined the willingness to initiate PrEP and the anticipation of HIV risk reduction while on PrEP among high-risk PWUD. METHODS: In a cross-sectional study of 400 HIV-negative, opioid dependent persons enrolled in a methadone program and reporting recent risk behaviors, we examined independent correlates of being willing to initiate PrEP...
February 2, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28176168/a-global-estimate-of-the-acceptability-of-pre-exposure-prophylaxis-for-hiv-among-men-who-have-sex-with-men-a-systematic-review-and-meta-analysis
#2
Peng Peng, Shu Su, Christopher K Fairley, Minjie Chu, Shengyang Jiang, Xun Zhuang, Lei Zhang
Pre-exposure prophylaxis (PrEP) is a new biomedical intervention for HIV prevention. This study systematically reviews the acceptability of PrEP among men who have sex with men (MSM) worldwide. We searched major English databases to identify English-language articles published between July 2007 and July 2016, which reported the acceptability of PrEP and associated population characteristics. Meta-analysis was conducted to estimate a pooled acceptability, and meta-regression and subgroup analysis were used to analyse heterogeneities...
February 7, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28170304/hiv-pre-exposure-prophylaxis-and-postexposure-prophylaxis-in-japan-context-of-use-and-directions-for-future-research-and-action
#3
Anthony S DiStefano, Makiko Takeda
Biomedical HIV prevention strategies are playing an increasingly prominent role in addressing HIV epidemics globally, but little is known about their use in Japan, where persistent HIV disparities and a recently stable, but not declining, national epidemic indicate the need for evolving approaches. We conducted an ethnographic study to determine the context of pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) use and to identify directions for future research and action in Japan. We used data from observational fieldwork in the Kansai region and Tokyo Metropolitan Area (n = 178 persons observed), qualitative interviews (n = 32), documents and web-based data sources (n = 321), and email correspondences (n = 9) in the period 2013-2016...
February 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28108878/stigma-and-conspiracy-beliefs-related-to-pre-exposure-prophylaxis-prep-and-interest-in-using-prep-among-black-and-white-men-and-transgender-women-who-have-sex-with-men
#4
Lisa A Eaton, Seth C Kalichman, Devon Price, Stephanie Finneran, Aerielle Allen, Jessica Maksut
The HIV/AIDS epidemic in the US continues to persist, in particular, among race, sexual orientation, and gender minority populations. Pre-exposure prophylaxis (PrEP), or using antiretroviral medications for HIV prevention, is an effective option, but uptake of PrEP has been slow. Sociocultural barriers to using PrEP have been largely underemphasized, yet have the potential to stall uptake and, therefore, warrant further understanding. In order to assess the relationships between potential barriers to PrEP (i...
January 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28080947/hiv-testing-intervention-development-among-men-who-have-sex-with-men-in-the-developed-world
#5
Paul Flowers, Claudia Estcourt, Pam Sonnenberg, Fiona Burns
HIV testing is a 'gateway' technology, enabling access to treatment and HIV prevention. Biomedical approaches to prevention, such as pre-exposure prophylaxis and treatment as prevention, require accurate and regular HIV test results. HIV testing also represents a powerful 'teachable moment' for behavioural prevention. An increasing range of HIV tests and the emergence of self-managed diagnostic technologies (e.g. self-testing) means there is now considerable diversification of when, where and how results are available to those who test...
January 13, 2017: Sexual Health
https://www.readbyqxmd.com/read/28062389/internet-based-hiv-prevention-with-at-home-sexually-transmitted-infection-testing-for-young-men-having-sex-with-men-study-protocol-of-a-randomized-controlled-trial-of-keep-it-up-2-0
#6
Brian Mustanski, Krystal Madkins, George J Greene, Jeffrey T Parsons, Brent A Johnson, Patrick Sullivan, Michael Bass, Rebekah Abel
BACKGROUND: Human immunodeficiency virus (HIV) infections are increasing among young men who have sex with men (YMSM), yet few HIV prevention programs have studied this population. Keep It Up! (KIU!), an online HIV prevention program tailored to diverse YMSM, was developed to fill this gap. The KIU! 2.0 randomized controlled trial (RCT) was launched to establish intervention efficacy. OBJECTIVE: The objective of the KIU! study is to advance scientific knowledge of technology-based behavioral HIV prevention, as well as improve public health by establishing the efficacy of an innovative electronic health (eHealth) prevention program for ethnically and racially diverse YMSM...
January 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28027663/hiv-risk-inside-u-s-prisons-a-systematic-review-of-risk-reduction-interventions-conducted-in-u-s-prisons
#7
Pamela Valera, Yvonne Chang, Zi Lian
HIV prevalence in correctional populations is approximately five times that of the general adult population. This systematic review examines the broad question of HIV prevention and interventions to reduce inmate HIV-related risk behaviors in U.S. federal and state prisons. We conducted a systematic review of multiple databases and Google Scholar to identify behavioral, biomedical, social, and policy studies related to HIV among U.S. prison populations from 1980-2014. Studies were excluded if they did not focus on HIV, prison inmates, if they were conducted outside of the U...
December 27, 2016: AIDS Care
https://www.readbyqxmd.com/read/27993129/hepatitis-viruses-in-ethiopia-a-systematic-review-and-meta-analysis
#8
Yeshambel Belyhun, Melanie Maier, Andargachew Mulu, Ermias Diro, Uwe Gerd Liebert
BACKGROUND: The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic review and meta-analysis was to provide a clear and comprehensive estimation of viral hepatitis epidemiology and the potential clinical burdens in Ethiopia. METHODS: A comprehensive literature search was carried out from five decades (1968-2015) published studies from biomedical databases; PubMed, Google scholar, Medline and Web of Science...
December 19, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27977386/stigma-gay-men-and-biomedical-prevention-the-challenges-and-opportunities-of-a-rapidly-changing-hiv-prevention-landscape
#9
Graham Brown, William Leonard, Anthony Lyons, Jennifer Power, Dirk Sander, William McColl, Ronald Johnson, Cary James, Matthew Hodson, Marina Carman
Improvements in biomedical technologies, combined with changing social attitudes to sexual minorities, provide new opportunities for HIV prevention among gay and other men who have sex with men (GMSM). The potential of these new biomedical technologies (biotechnologies) to reduce HIV transmission and the impact of HIV among GMSM will depend, in part, on the degree to which they challenge prejudicial attitudes, practices and stigma directed against gay men and people living with HIV (PLHIV). At the structural level, stigma regarding gay men and HIV can influence the scale-up of new biotechnologies and negatively affect GMSM's access to and use of these technologies...
December 16, 2016: Sexual Health
https://www.readbyqxmd.com/read/27930472/risks-associated-with-lentiviral-vector-exposures-and-prevention-strategies
#10
Ryan Schlimgen, John Howard, Dawn Wooley, Maureen Thompson, Lindsey R Baden, Otto O Yang, David C Christiani, Gustavo Mostoslavsky, David V Diamond, Elizabeth Gilman Duane, Karen Byers, Thomas Winters, Jeffrey A Gelfand, Gary Fujimoto, T Warner Hudson, Jatin M Vyas
Lentiviral vectors (LVVs) are powerful genetic tools that are being used with greater frequency in biomedical laboratories and clinical trials. Adverse events reported from initial clinical studies provide a basis for risk assessment of occupational exposures, yet many questions remain about the potential harm that LVVs may cause. We review those risks and provide a framework for principal investigators, Institutional Biosafety Committees, and occupational health professionals to assess and communicate the risks of exposure to staff...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27925484/risk-factors-associated-with-repeated-hiv-testing-among-internet-using-men-who-have-sex-with-men
#11
Brent A Johnson, Jennie McKenney, Alexandra V Ricca, Eli S Rosenberg, Chang Liu, Akshay Sharma, Patrick S Sullivan
: Men who have sex with men (MSM) represent a disproportionately impacted risk group for HIV incidence among at-risk U.S. POPULATIONS: Few studies have identified risk factors associated with HIV testing frequency both within and outside of traditional health care settings. MSM enrolled in a prospective cohort were mailed at-home specimen collection kits and followed for a year. Incidence density rate ratios (IDRR) of testing were calculated, and generalized estimating equations were used to analyze the association between HIV testing and behavioral factors...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27906028/re-focusing-hiv-prevention-messages-a-qualitative-study-in-rural-uganda
#12
Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda, John S Santelli
BACKGROUND: After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus on HIV prevention messages to motivate engagement in risk-reduction activities. This paper examines youth and adult perceptions of HIV prevention messages and HIV risk assessment in a generalized HIV epidemic context in Uganda. METHODS: We conducted 24 focus group discussions and 24 in-depth interviews with 15-45 year olds (n = 218) from three communities in the Rakai district of Uganda in 2012...
November 11, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905986/predictors-of-perceived-male-partner-concurrency-among-women-at-risk-for-hiv-and-sti-acquisition-in-durban-south-africa
#13
Zakir Gaffoor, Handan Wand, Renée A Street, Nathlee Abbai, Gita Ramjee
BACKGROUND: Women in sub-Saharan Africa continue to be at greater risk for HIV acquisition than men. Concurrency, viz. multiple sexual partnerships that overlap over time, has been studied as a possible risk factor for HIV transmission. The aim of this study was to identify predictors of perceived male partner concurrency among sexually active, HIV negative women. METHODS: Socio-demographic and behavioural data from women enrolled in a biomedical HIV prevention clinical trial were assessed in relation to perceived male partner concurrency using the Chi squared test...
March 8, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27883309/likely-impact-of-pre-exposure-prophylaxis-on-hiv-epidemics-among-men-who-have-sex-with-men
#14
Iryna B Zablotska
Rapid developments in the field of HIV pre-exposure prophylaxis (PrEP) with antiretrovirals offer a promise to bring HIV transmission among gay and other men who have sex with men (MSM) to zero by 2030. This review evaluates studies, which modelled the impact of PrEP on HIV diagnoses, and discusses the progress towards PrEP implementation. Studies in English, conducted after 2010 among MSM in countries of the Organization for Economic Cooperation and Development (OECD) were reviewed. Six modelling studies were included, three of which had been conducted outside the US...
November 25, 2016: Sexual Health
https://www.readbyqxmd.com/read/27872326/pre-exposure-prophylaxis-prep-for-men-who-have-sex-with-men-in-europe-review-of-evidence-for-a-much-needed-prevention-tool
#15
REVIEW
Thijs Reyniers, Elske Hoornenborg, Bea Vuylsteke, Kristien Wouters, Marie Laga
In many Western countries with good coverage of antiretroviral treatment (ART) programmes the annual number of HIV infections is still high and not (yet) declining among men who have sex with men (MSM). This might indicate that antiretroviral treatment roll-out alone will not turn around the course of the epidemic and that new, additional tools are needed. Antiretrovirals used as prevention tools for people not yet infected with HIV, such as pre-exposure prophylaxis (PrEP) could be such important additional tools...
November 21, 2016: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/27857775/re-focusing-hiv-prevention-messages-a-qualitative-study-in-rural-uganda
#16
Sanyukta Mathur, Dina Romo, Mariko Rasmussen, Neema Nakyanjo, Fred Nalugoda, John S Santelli
BACKGROUND: After 30 years, the human immunodeficiency virus (HIV) remains an epidemic of global concern. To support the increasing emphasis on biomedical interventions for prevention requires a renewed and reframed focus on HIV prevention messages to motivate engagement in risk-reduction activities. This paper examines youth and adult perceptions of HIV prevention messages and HIV risk assessment in a generalized HIV epidemic context in Uganda. METHODS: We conducted 24 focus group discussions and 24 in-depth interviews with 15-45 year olds (n = 218) from three communities in the Rakai district of Uganda in 2012...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27851715/brief-report-high-hiv-incidence-in-a-south-african-community-of-men-who-have-sex-with-men-results-from-the-mpumalanga-men-s-study-2012-2015
#17
Tim Lane, Thomas Osmand, Alexander Marr, Helen Struthers, James A McIntyre, Starley B Shade
Cross-sectional studies among African men who have sex with men (MSM) populations demonstrate high HIV prevalence, but few incidence estimates exist. The Mpumalanga Men's Study in Gert Sibande, Mpumalanga province, South Africa, involved 3 serial cross-sectional surveys of MSM recruited through respondent-driven sampling between 2012 and 2015. Successive surveys recaptured a nested cohort of 179, contributing 144.3 person-years (PY) of observation. We observed 18 seroconversions, or incidence of 12.5/100 (PY) (95% confidence interval CI: 8...
December 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27848950/the-rectal-mucosa-and-condomless-receptive-anal-intercourse-in-hiv-negative-msm-implications-for-hiv-transmission-and-prevention
#18
C F Kelley, C S Kraft, T Jb de Man, C Duphare, H-W Lee, J Yang, K A Easley, G K Tharp, M J Mulligan, P S Sullivan, S E Bosinger, R R Amara
Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we performed a comprehensive characterization of the rectal mucosal immune environment for the phenotype and production of pro-inflammatory cytokines by CD4 and CD8 T cells, global transcriptomic analyses, and the composition of microbiota in HIV-negative MSM...
November 16, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27832389/efficacy-of-human-immunodeficiency-virus-sexually-transmitted-infection-prevention-interventions-targeting-female-entertainment-workers-a-systematic-review-and-meta-analysis
#19
REVIEW
Raymond Boon Tar Lim, Dede Kam Tyng Tham, Olive N Y Cheung, Mee Lian Wong
Female entertainment workers (FEWs) working in karaoke lounges, bars, pubs, nightclubs, discotheques, dance halls, massage parlours, restaurants (as hostesses or singers) and beer gardens are at high risk for human immunodeficiency virus (HIV)/sexually transmitted infection (STI). The aim of the systematic review and meta-analysis is to evaluate the efficacy of HIV/STI intervention programmes targeting FEWs. Among the 14 included studies, majority were in Asia and targeted native FEWs. Most studies were quasi-experimental and the overall quality was relatively low...
November 10, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27828875/antiretroviral-drug-use-in-a-cross-sectional-population-survey-in-africa-nimh-project-accept-hptn-043
#20
Jessica M Fogel, William Clarke, Michal Kulich, Estelle Piwowar-Manning, Autumn Breaud, Matthew T Olson, Mark A Marzinke, Oliver Laeyendecker, Agnès Fiamma, Deborah Donnell, Jessie K K Mbwambo, Linda Richter, Glenda Gray, Michael Sweat, Thomas J Coates, Susan H Eshleman
BACKGROUND: Antiretroviral (ARV) drug treatment benefits the treated individual and can prevent HIV transmission. We assessed ARV drug use in a community-randomized trial that evaluated the impact of behavioral interventions on HIV incidence. METHODS: Samples were collected in a cross-sectional survey after a 3-year intervention period. ARV drug testing was performed using samples from HIV-infected adults at 4 study sites (Zimbabwe; Tanzania; KwaZulu-Natal and Soweto, South Africa; survey period 2009-2011) using an assay that detects 20 ARV drugs (6 nucleoside/nucleotide reverse transcriptase inhibitors, 3 nonnucleoside reverse transcriptase inhibitors, and 9 protease inhibitors; maraviroc; raltegravir)...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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