Laura Banov, Marco Pavanello, Gianluca Piattelli, Nicola Disma, Mariasavina Severino, Carlo Dufour, Angelo Claudio Molinari
We report an urgent aggressive neurosurgery procedure for a large life-threatening intracranial bleed in a 3-year-old boy with severe haemophilia A and high titre inhibitor, managed with mega doses of recombinant-activated FVII (rFVIIa). We infused preoperatively bolus of 350 μg/kg, repeated every 2 h for 4 days. There were no bleeding complications during surgery. Afterward, rFVIIa was gradually tapered acting alternatively on dose and timing, until the ongoing schedule of 214 μg/kg every 12 h.To our knowledge this is the first report of aggressive neurosurgery in a boy with high titre inhibitor, successfully managed with high doses rFVIIa...
July 2014: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis