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Jose ordovas

Yiyi Ma, Jose M Ordovas
There is increasing evidence documenting gene-by-environment (G × E) interactions for CVD related traits. However, the underlying mechanisms are still unclear. DNA methylation may represent one of such potential mechanisms. The objective of this review paper is to summarise the current evidence supporting the interplay among DNA methylation, genetic variants, and environmental factors, specifically (1) the association between SNP and DNA methylation; (2) the role that DNA methylation plays in G × E interactions...
December 6, 2016: Proceedings of the Nutrition Society
Kenneth Day, Lindsay L Waite, Arnald Alonso, Marguerite R Irvin, Degui Zhi, Krista S Thibeault, Stella Aslibekyan, Bertha Hidalgo, Ingrid B Borecki, Jose M Ordovas, Donna K Arnett, Hemant K Tiwari, Devin M Absher
DNA methylation at CpG sites is both heritable and influenced by environment, but the relative contributions of each to DNA methylation levels are unclear. We conducted a heritability analysis of CpG methylation in human CD4+ cells across 975 individuals from 163 families in the Genetics of Lipid-lowering Drugs and Diet Network (GOLDN). Based on a broad-sense heritability (H2) value threshold of 0.4, we identified 20,575 highly heritable CpGs among the 174,445 most variable autosomal CpGs (SD > 0.02). Tests for associations of heritable CpGs with genotype at 2,145,360 SNPs using 717 of 975 individuals showed that ~74% were cis-meQTLs (< 1 Mb away from the CpG), 6% of CpGs exhibited trans-meQTL associations (>1 Mb away from the CpG or located on a different chromosome), and 20% of CpGs showed no strong significant associations with genotype (based on a p-value threshold of 1e-7)...
2016: PloS One
Chao-Qiang Lai, Mary K Wojczynski, Laurence D Parnell, Bertha A Hidalgo, Marguerite Ryan Irvin, Stella Aslibekyan, Michael A Province, Devin M Absher, Donna K Arnett, José M Ordovás
Postprandial lipemia (PPL), the increased plasma TG concentration after consuming a high-fat meal, is an independent risk factor for CVD. Individual responses to a meal high in fat vary greatly, depending on genetic and lifestyle factors. However, only a few loci have been associated with TG-PPL response. Heritable epigenomic changes may be significant contributors to the unexplained inter-individual PPL variability. We conducted an epigenome-wide association study on 979 subjects with DNA methylation measured from CD4(+) T cells, who were challenged with a high-fat meal as a part of the Genetics of Lipid Lowering Drugs and Diet Network study...
December 2016: Journal of Lipid Research
Latisha Love-Gregory, Aldi T Kraja, Fiona Allum, Stella Aslibekyan, Åsa K Hedman, Yanan Duan, Ingrid B Borecki, Donna K Arnett, Mark I McCarthy, Panos Deloukas, Jose M Ordovas, Paul N Hopkins, Elin Grundberg, Nada A Abumrad
Cluster of differentiation 36 (CD36) variants influence fasting lipids and risk of metabolic syndrome, but their impact on postprandial lipids, an independent risk factor for cardiovascular disease, is unclear. We determined the effects of SNPs within a ∼410 kb region encompassing CD36 and its proximal and distal promoters on chylomicron (CM) remnants and LDL particles at fasting and at 3.5 and 6 h following a high-fat meal (Genetics of Lipid Lowering Drugs and Diet Network study, n = 1,117). Five promoter variants associated with CMs, four with delayed TG clearance and five with LDL particle number...
December 2016: Journal of Lipid Research
Francisco Gomez-Delgado, Javier Delgado-Lista, Javier Lopez-Moreno, Oriol Alberto Rangel-Zuñiga, Juan Francisco Alcala-Diaz, Ana Leon-Acuña, Andreea Corina, Elena Yubero-Serrano, Jose David Torres-Peña, Antonio Camargo, Antonio Garcia-Rios, Javier Caballero, Justo Castaño, Jose M Ordovas, Jose Lopez-Miranda, Pablo Perez-Martinez
BACKGROUND: Leukocyte telomere length (LTL) attrition has been associated with age-related diseases. Telomerase RNA Component (TERC) genetic variants have been associated with LTL; whereas fatty acids (FAs) can interact with genetic factors and influence in aging. We explore whether variability at the TERC gene locus interacts with FA profile and two healthy diets (low-fat diet vs Mediterranean diet [MedDiet]) modulating LTL, glucose metabolism, and inflammation status in coronary heart disease (CHD) patients...
October 5, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Pablo Perez-Martinez, Juan F Alcala-Diaz, Edmon K Kabagambe, Antonio Garcia-Rios, Michael Y Tsai, Javier Delgado-Lista, Genovefa Kolovou, Robert J Straka, Francisco Gomez-Delgado, Paul N Hopkins, Carmen Marin, Ingrid Borecki, Elena M Yubero-Serrano, James E Hixson, Antonio Camargo, Michael A Province, Javier Lopez-Moreno, Fernando Rodriguez-Cantalejo, Francisco J Tinahones, Dimitri P Mikhailidis, Francisco Perez-Jimenez, Donna K Arnett, Jose M Ordovas, Jose Lopez-Miranda
BACKGROUND: Previous studies have suggested that for clinical purposes, subjects with fasting triglycerides (TGs) between 89-180 mg/dl (1-2 mmol/l) would benefit from postprandial TGs testing. OBJECTIVE: To determine the postprandial TG response in 2 independent studies and validate who should benefit diagnostically from an oral-fat tolerance test (OFTT) in clinical practice. METHODS: A population of 1002 patients with coronary heart disease (CHD) from the CORDIOPREV clinical trial and 1115 white US subjects from the GOLDN study underwent OFTTs...
September 2016: Journal of Clinical Lipidology
Marta Garaulet, Beatriz Vera, Gemma Bonnet-Rubio, Purificación Gómez-Abellán, Yu-Chi Lee, José M Ordovás
BACKGROUND: We propose that eating lunch late impairs the mobilization of fat from adipose tissue, particularly in carriers of PERILIPIN1 (PLIN1) variants. OBJECTIVE: The aim was to test the hypothesis that PLIN1, a circadian lipid-stabilizing protein in the adipocyte, interacts with the timing of food intake to affect weight loss. DESIGN: A total of 1287 overweight and obese subjects [229 men and 1058 women; mean ± SD body mass index (in kg/m(2)): 31 ± 5] who attended outpatient obesity clinics were enrolled in the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study...
October 2016: American Journal of Clinical Nutrition
Sabrina E Noel, Sandra Arevalo, Caren E Smith, Chao-Qiang Lai, Bess Dawson-Hughes, Jose M Ordovas, Katherine L Tucker
Population admixture plays a role in the risk of chronic conditions that are related to body composition; however, our understanding of these associations in Puerto Ricans, a population characterized by multiple ancestries, is limited. This study investigated the relationship between genetic admixture and body composition in 652 Puerto Ricans from the Boston Puerto Rican Osteoporosis Study. Genetic ancestry was estimated from 100 ancestry-informative markers. Body composition measures were obtained from dual-energy X-ray absorptiometry...
September 14, 2016: Journal of Bone and Mineral Metabolism
Caren E Smith, Oscar Coltell, Jose V Sorlí, Ramón Estruch, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Montserrat Fitó, Fernando Arós, Hassan S Dashti, Chao Q Lai, Leticia Miró, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Emilio Ros, Stella Aslibekyan, Bertha Hidalgo, Marian L Neuhouser, Chongzhi Di, Katherine L Tucker, Donna K Arnett, José M Ordovás, Dolores Corella
Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations...
September 14, 2016: Scientific Reports
José L Peñalvo, Leticia Fernández-Friera, Beatriz López-Melgar, Irina Uzhova, Belén Oliva, Juan Miguel Fernández-Alvira, Martín Laclaustra, Stuart Pocock, Agustín Mocoroa, José M Mendiguren, Ginés Sanz, Eliseo Guallar, Sameer Bansilal, Rajesh Vedanthan, Luis Jesús Jiménez-Borreguero, Borja Ibañez, José M Ordovás, Antonio Fernández-Ortiz, Héctor Bueno, Valentin Fuster
BACKGROUND: The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. OBJECTIVES: This study sought to quantify the association between specific dietary patterns and presence and extent of subclinical atherosclerosis in a population of asymptomatic middle-aged adults. METHODS: The PESA (Progression of Early Subclinical Atherosclerosis) study enrolled 4,082 asymptomatic participants 40 to 54 years of age (mean age 45...
August 23, 2016: Journal of the American College of Cardiology
Rocío Barragán, Oscar Coltell, Eva M Asensio, Francesc Francés, José V Sorlí, Ramon Estruch, Albert Salas-Huetos, Jose M Ordovas, Dolores Corella
Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire...
2016: International Journal of Molecular Sciences
Caren E Smith, Stephanie M Fullerton, Keith A Dookeran, Heather Hampel, Adrienne Tin, Nisa M Maruthur, Jonathan C Schisler, Jeffrey A Henderson, Katherine L Tucker, José M Ordovás
Evidence shows that both biological and nonbiological factors contribute to health disparities. Genetics, in particular, plays a part in how common diseases manifest themselves. Today, unprecedented advances in genetically based diagnoses and treatments provide opportunities for personalized medicine. However, disadvantaged groups may lack access to these advances, and treatments based on research on non-Hispanic whites might not be generalizable to members of minority groups. Unless genetic technologies become universally accessible, existing disparities could be widened...
August 1, 2016: Health Affairs
Javier Aranceta-Bartrina, Ángel Gil, Ascensión Marcos, Carmen Pérez-Rodrigo, Lluis Serra-Majem, Gregorio Varela-Moreiras
Javier Aranceta-Bartrina1, Ángel Gil2, Ascensión Marcos3, Carmen Pérez-Rodrigo4, Lluis Serra-Majem5 and Gregorio Varela-Moreiras6*1Associate Professor at University of Navarra. Pamplona, Spain. 2Professor of Biochemistry and Molecular Biology. University of Granada. Granada, Spain. 3Research Professor at the Spanish National Research Council (CSIC). Madrid, Spain. 4President of Spanish Society of Community Nutrition (SENC). Bilbao, Spain. 5Professor of Preventive Medicine and Public Health. Director of Group of Nutrition...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Oriol Alberto Rangel-Zúñiga, Andreea Corina, Beatriz Lucena-Porras, Cristina Cruz-Teno, Francisco Gómez-Delgado, Rosa Jiménez-Lucena, Juan Francisco Alcalá-Díaz, Carmen Haro-Mariscal, Elena María Yubero-Serrano, Javier Delgado-Lista, Javier López-Moreno, Fernando Rodríguez-Cantalejo, Antonio Camargo, Francisco José Tinahones, José María Ordovás, José López-Miranda, Pablo Pérez-Martínez
BACKGROUND: Several single nucleotide polymorphisms have been proposed as potential predictors of the development of age-related diseases. OBJECTIVE: To explore whether Tumor Necrosis Factor Alpha (TNFA) gene variants were associated with inflammatory status, thus facilitating the rate of telomere shortening and its relation to cellular aging in a population with established cardiovascular disease from the CORDIOPREV study (NCT00924937). MATERIALS AND METHODS: SNPs (rs1800629 and rs1799964) located at the TNFA gene were genotyped by OpenArray platform in 840 subjects with established cardiovascular disease...
October 2016: Experimental Gerontology
Elena M Yubero-Serrano, Javier Delgado-Lista, Juan F Alcala-Diaz, Antonio Garcia-Rios, Ana I Perez-Caballero, Ruth Blanco-Rojo, Francisco Gomez-Delgado, Carmen Marin, Francisco J Tinahones, Javier Caballero, Jose M Ordovas, Ben van Ommen, Francisco Perez-Jimenez, Pablo Perez-Martinez, Jose Lopez-Miranda
BACKGROUND AND AIMS: Patients with coexisting coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular recurrence, however, it is not well established whether they exhibit an increased intima-media thickness of both common carotid arteries (IMT-CC). Furthermore, whether this relationship is inherent to T2DM or depends on glycemic control has not been tested in large cohorts. Our aim was to determine whether clinical categories and/or analytical markers of glucose metabolism control were associated with IMT-CC in CHD patients...
October 2016: Atherosclerosis
Javier Aranceta-Bartrina, Ángel Gil, Ascensión Marcos, Carmen Pérez-Rodrigo, Lluis Serra-Majem, Gregorio Varela-Moreiras
Javier Aranceta-Bartrina1, Ángel Gil2, Ascensión Marcos3, Carmen Pérez-Rodrigo4, Lluis Serra-Majem5 and Gregorio Varela-Moreiras6*1Associate Professor at University of Navarra. Pamplona, Spain. 2Professor of Biochemistry and Molecular Biology. University of Granada. Granada, Spain. 3Research Professor at the Spanish National Research Council (CSIC). Madrid, Spain. 4President of Spanish Society of Community Nutrition (SENC). Bilbao, Spain. 5Professor of Preventive Medicine and Public Health. Director of Group of Nutrition...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Ruth Blanco-Rojo, Javier Delgado-Lista, Yu-Chi Lee, Chao-Qiang Lai, Pablo Perez-Martinez, Oriol Rangel-Zuñiga, Caren E Smith, Bertha Hidalgo, Juan F Alcala-Diaz, Francisco Gomez-Delgado, Laurence D Parnell, Donna K Arnett, Katherine L Tucker, Jose Lopez-Miranda, Jose M Ordovas
BACKGROUND: S100 calcium-binding protein A9 (S100A9) has previously been identified as a type 2 diabetes (T2D) gene. However, this finding requires independent validation and more in-depth analyses in other populations and ancestries. OBJECTIVES: We aimed to replicate the associations between an S100A9 variant and insulin resistance and T2D and to initiate an investigation of potential interactions with the habitual diet in several independent populations. DESIGN: We investigated the association of the S100A9 variant rs3014866 with insulin resistance and T2D risk and its interactions with diet in 3 diverse populations as follows: the CORDIOPREV (Coronary Diet Intervention with Olive Oil and Cardiovascular Prevention; n = 711), which consisted of Spanish white adults; the GOLDN (Genetics of Lipids Lowering Drugs and Diet Network; n = 818), which involved North American non-Hispanic white adults; and Hispanic adults who participated in the BPRHS (Boston Puerto Rican Health Study; n = 1155)...
August 2016: American Journal of Clinical Nutrition
Xiao-Xuan Xin, Yong Chen, Di Chen, Fa Xiao, Laurence D Parnell, Jing Zhao, Liang Liu, Jose M Ordovas, Chao-Qiang Lai, Li-Rong Shen
The major royal-jelly proteins (MRJPs) are the main constituents responsible for the specific physiological role of royal jelly (RJ) in honeybees. Male and female Drosophila flies were fed diets containing either no MRJPs (A) or casein (B) at 1.25% (w/w) of diet or MRJPs at 1.25% (C), 2.50% (D), or 5.00% (E). Diets B, C, D, and E increased mean lifespan by 4.3%, 9.0%, 12.4%, and 13.9% in males and by 5.8%, 9.7%, 20.0%, and 11.8% in females in comparison to results from diet A, respectively. The diet supplemented with 2...
July 27, 2016: Journal of Agricultural and Food Chemistry
Javier Delgado-Lista, Pablo Perez-Martinez, Antonio Garcia-Rios, Juan F Alcala-Diaz, Ana I Perez-Caballero, Francisco Gomez-Delgado, Francisco Fuentes, Gracia Quintana-Navarro, Fernando Lopez-Segura, Ana M Ortiz-Morales, Nieves Delgado-Casado, Elena M Yubero-Serrano, Antonio Camargo, Carmen Marin, Fernando Rodriguez-Cantalejo, Purificacion Gomez-Luna, Jose M Ordovas, Jose Lopez-Miranda, Francisco Perez-Jimenez
Coronary heart disease (CHD) represents a major global health burden. However, despite the well-known influence that dietary habits exert over the progression of this disease, there are no well-established and scientifically sound dietary approaches to prevent the onset of clinical outcomes in secondary prevention. The objective of the CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (CORDIOPREV study, clinical trials number NCT00924937) is to compare the ability of a Mediterranean diet rich in virgin olive oil versus a low-fat diet to influence the composite incidence of cardiovascular events after 7 years in subjects with documented CHD at baseline...
July 2016: American Heart Journal
Eva Talavera-Garcia, Javier Delgado-Lista, Antonio Garcia-Rios, Nieves Delgado-Casado, Purificacion Gomez-Luna, Angela Gomez-Garduño, Francisco Gomez-Delgado, Juan F Alcala-Diaz, Elena Yubero-Serrano, Carmen Marin, Ana I Perez-Caballero, Francisco J Fuentes-Jimenez, Antonio Camargo, Fernando Rodriguez-Cantalejo, Francisco J Tinahones, Jose M Ordovas, Francisco Perez-Jimenez, Pablo Perez-Martinez, Jose Lopez-Miranda
[This corrects the article DOI: 10.1371/journal.pone.0153096.].
2016: PloS One
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