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https://www.readbyqxmd.com/read/29573224/mediterranean-diet-glucose-homeostasis-and-inflammasome-genetic-variants-the-cordioprev-study
#1
Irene Roncero-Ramos, Oriol A Rangel-Zuñiga, Javier López-Moreno, Juan F Alcala-Diaz, Pablo Perez-Martinez, Rosa Jimenez-Lucena, Justo P Castaño, Helen M Roche, Javier Delgado-Lista, Jose M Ordovas, Antonio Camargo, Jose Lopez-Miranda
SCOPE: Insulin resistance (IR) and chronic low-grade inflammation are hallmarks of Type 2 Diabetes Mellitus (T2DM). The 'NOD-like receptor pyrin domain containing-3' (NLRP3) inflammasome component of innate immunity is a metabolic stress sensor modulated by dietary and genetics factors. The aim of this study was to evaluate the effects of the consumption of two diets for 3 years, Med and low-fat, on glucose homeostasis in the 1002 coronary heart disease patients of the CORDIOPREV study, according to a genetic variant of NLRP3 inflammasome...
March 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29504317/supplementation-with-turmeric-residue-increased-survival-of-the-chinese-soft-shelled-turtle-pelodiscus-sinensis-under-high-ambient-temperatures
#2
Yong Chen, Yi-Fan Zhang, Hao-Cheng Qian, Jing-Liang Wang, Zhe Chen, Jose M Ordovas, Chao-Qiang Lai, Li-Rong Shen
Turmeric residue (TR), containing residual levels of curcumin, is a solid by-product waste generated after the extraction and separation of curcumin from turmeric root. A feeding trial was conducted to evaluate the effects of TR on the survival of Chinese soft-shelled turtles (SSTs), Pelodiscus sinensis, under a high ambient temperature. A total of 320 female SSTs were assigned randomly to two diets: basal diet (the control group, n=160) and an interventional diet supplemented with 10% TR (the TR group, n=160)...
2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29463568/an-exome-wide-sequencing-study-of-lipid-response-to-high-fat-meal-and-fenofibrate-in-caucasians-from-the-goldn-cohort
#3
Xin Geng, Marguerite R Irvin, Bertha Hidalgo, Stella Aslibekyan, Vinodh Srinivasasainagendra, Ping An, Alexis Frazier-Wood, Hemant K Tiwari, Tushar Dave, Kathleen Ryan, Jose M Ordovas, Robert J Straka, Mary F Feitosa, Paul N Hopkins, Ingrid Borecki, Michael A Province, Braxton D Mitchell, Donna K Arnett, Degui Zhi
Our understanding of genetic influences on the response of lipids to specific interventions is limited. In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therapy in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort using an exome-wide sequencing-based association study. Our results showed that the rare coding variants in ITGA7, SIPA1L2, and CEP72 are significantly associated with fasting low-density lipoprotein cholesterol (LDL-C) response to FFB (P=1...
February 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29400994/advances-in-understanding-the-molecular-basis-of-the-mediterranean-diet-effect
#4
Dolores Corella, Oscar Coltell, Fernando Macian, José M Ordovás
Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. The scientific evidence level for each outcome is variable, and new studies are needed to better understand the molecular mechanisms whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases but also discussing other related diseases...
March 25, 2018: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/29382920/a-systematic-analysis-highlights-multiple-long-non-coding-rnas-associated-with-cardiometabolic-disorders
#5
Mohsen Ghanbari, Marjolein J Peters, Paul S de Vries, Cindy G Boer, Jeroen G J van Rooij, Yu-Chi Lee, Vinod Kumar, André G Uitterlinden, M Arfan Ikram, Cisca Wijmenga, Jose M Ordovas, Caren E Smith, Joyce B J van Meurs, Stefan J Erkeland, Oscar H Franco, Abbas Dehghan
Genome-wide association studies (GWAS) have identified many susceptibility loci for cardiometabolic disorders. Most of the associated variants reside in non-coding regions of the genome including long non-coding RNAs (lncRNAs), which are thought to play critical roles in diverse biological processes. Here, we leveraged data from the available GWAS meta-analyses on lipid and obesity-related traits, blood pressure, type 2 diabetes, and coronary artery disease and identified 179 associated single-nucleotide polymorphisms (SNPs) in 102 lncRNAs (p-value < 2...
January 30, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29378643/a-reproducibility-based-computational-framework-identifies-an-inducible-enhanced-antiviral-state-in-dendritic-cells-from-hiv-1-elite-controllers
#6
Enrique Martin-Gayo, Michael B Cole, Kellie E Kolb, Zhengyu Ouyang, Jacqueline Cronin, Samuel W Kazer, Jose Ordovas-Montanes, Mathias Lichterfeld, Bruce D Walker, Nir Yosef, Alex K Shalek, Xu G Yu
BACKGROUND: Human immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and communication could thus potentially alter host protection. Here, we explore this hypothesis by applying single-cell RNA-sequencing to examine viral responses among the dendritic cells (DCs) of three elite controllers (ECs) of HIV-1 infection. RESULTS: To overcome the potentially confounding effects of donor-to-donor variability, we present a generally applicable computational framework for identifying reproducible patterns in gene expression across donors who share a unifying classification...
January 29, 2018: Genome Biology
https://www.readbyqxmd.com/read/29333649/detection-of-gene-environment-interactions-in-a-family-based-population-using-scad
#7
Gwangsu Kim, Chao-Qiang Lai, Donna K Arnett, Laurence D Parnell, Jose M Ordovas, Yongdai Kim, Joungyoun Kim
No abstract text is available yet for this article.
February 10, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29325163/trans-ethnic-evaluation-identifies-novel-low-frequency-loci-associated-with-25-hydroxyvitamin-d-concentrations
#8
Jaeyoung Hong, Kathryn E Hatchell, Jonathan P Bradfield, Bjonnes Andrew, Chesi Alessandra, Lai Chao-Qiang, Carl D Langefeld, Lingyi Lu, Yingchang Lu, Pamela L Lutsey, Solomon K Musani, Mike A Nalls, Cassianne Robinson-Cohen, Jeffery D Roizen, Richa Saxena, Katherine L Tucker, Julie T Ziegler, Dan E Arking, Joshua C Bis, Eric Boerwinkle, Erwin P Bottinger, Donald W Bowden, Vincente Gilsanz, Denise K Houston, Heidi J Kalkwarf, Andrea Kelly, Joan M Lappe, Yongmei Liu, Erin D Michos, Sharon E Oberfield, Nicholette D Palmer, Jerome I Rotter, Bishwa Sapkota, John A Shepherd, James G Wilson, Saonli Basu, Ian H de Boer, Jasmin Divers, Barry I Freedman, Struan F A Grant, Hakon Hakanarson, Tamara B Harris, Bryan R Kestenbaum, Stephen B Kritchevsky, Ruth J F Loos, Jill M Norris, Arnita F Norwood, Jose M Ordovas, James S Pankow, Bruce M Psaty, Dharambir K Sanhgera, Lynne E Wagenknecht, Babette S Zemel, James Meigs, Josée Dupuis, Jose C Florez, Thomas Wang, Ching-Ti Liu, Corinne D Engelman, Liana K Billings
Context: Vitamin D inadequacy is common in the adult population of the United States. While the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is known in Hispanic or African ancestry populations. Objective: The TRANSCEN-D (TRANS-ethniC Evaluation of vitamiN D GWAS) consortium was assembled to replicate genetic associations with 25-hydroxyvitamin D (25(OH)D) concentrations from the meta-analyses of European ancestry (SUNLIGHT) and to identify novel genetic variants related to vitamin D concentrations in African and Hispanic ancestries...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29305130/effects-of-the-ser326cys-polymorphism-in-the-dna-repair-ogg1-gene-on-cancer-cardiovascular-and-all-cause-mortality-in-the-predimed-study-modulation-by-diet
#9
Dolores Corella, Judith B Ramírez-Sabio, Oscar Coltell, Carolina Ortega-Azorín, Ramón Estruch, Miguel A Martínez-González, Jordi Salas-Salvadó, José V Sorlí, Olga Castañer, Fernando Arós, Franscisco J Garcia-Corte, Lluís Serra-Majem, Enrique Gómez-Gracia, Miquel Fiol, Xavier Pintó, Guillermo T Saez, Estefanía Toledo, Josep Basora, Montserrat Fitó, Montserrat Cofán, Emilio Ros, Jose M Ordovas
BACKGROUND: Oxidatively induced DNA damage, an important factor in cancer etiology, is repaired by oxyguanine glycosylase 1 (OGG1). The lower repair capacity genotype (homozygote Cys326Cys) in the OGG1-rs1052133 (Ser326Cys) polymorphism has been associated with cancer risk. However, no information is available in relation to cancer mortality, other causes of death, and modulation by diet. OBJECTIVE: Our aim was to evaluate the association of the OGG1-rs1052133 with total, cancer, and cardiovascular disease (CVD) mortality and to analyze its modulation by the Mediterranean diet, focusing especially on total vegetable intake as one of the main characteristics of this diet...
April 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29274507/mediterranean-diet-improves-endothelial-function-in-patients-with-diabetes-and-prediabetes-a-report-from-the-cordioprev-study
#10
Jose D Torres-Peña, Antonio Garcia-Rios, Nieves Delgado-Casado, Purificacion Gomez-Luna, Juan F Alcala-Diaz, Elena M Yubero-Serrano, Francisco Gomez-Delgado, Ana Leon-Acuña, Javier Lopez-Moreno, Antonio Camargo, Francisco J Tinahones, Javier Delgado-Lista, Jose M Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda
BACKGROUND AND AIMS: Endothelial dysfunction (ED) plays a key role in the development of atherosclerotic cardiovascular disease (ASCVD). Likewise, type 2 diabetes (T2D) is a major CVD risk factor. Therefore, our objective was to explore whether long-term consumption of a Mediterranean diet (MedDiet) rich in olive oil or a low-fat diet (LF diet) was associated with an improvement in ED and whether the potential benefits were similar in patients with or without T2D in the CORDIOPREV clinical trial (NCT00924937)...
February 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29135687/environmental-and-epigenetic-regulation-of-postprandial-lipemia
#11
Laurence D Parnell, Jose M Ordovas, Chao-Qiang Lai
PURPOSE OF REVIEW: Postprandial lipemia (PPL), the prolonged increase in plasma triglyceride-rich lipoproteins following food consumption, is an independent risk factor for cardiovascular disease. Genetic variation, environment and the interplay between these direct an individual's postprandial lipid response. From such interplay, inducible and reversible epigenetic changes arise. Increasing evidence suggests epigenetic variation contributes to postprandial response in lipids and risk...
February 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29129737/endotoxemia-is-modulated-by-quantity-and-quality-of-dietary-fat-in-older-adults
#12
Javier Lopez-Moreno, Sonia Garcia-Carpintero, Francisco Gomez-Delgado, Rosa Jimenez-Lucena, Cristina Vals-Delgado, Juan F Alcala-Diaz, Irene Roncero-Ramos, Oriol A Rangel-Zuñiga, Elena M Yubero-Serrano, Maria M Malagon, Jose M Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda, Antonio Camargo
BACKGROUND: Aging is an important determinant of the rate of atherosclerosis development, mainly through low-grade inflammation. Diet, and particularly its fat content, modulates the inflammatory response in fasting and postprandial states. OBJECTIVE: We aimed to study the effects of dietary fat on endotoxemia in healthy older adults. MATERIALS AND METHODS: Twenty healthy older adults were randomized to three diets, lasting three-weeks each, using a crossover design: 1...
November 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29104244/a-multi-locus-genetic-risk-score-for-primary-open-angle-glaucoma-poag-variants-is-associated-with-poag-risk-in-a-mediterranean-population-inverse-correlations-with-plasma-vitamin-c-and-e-concentrations
#13
Vicente Zanon-Moreno, Carolina Ortega-Azorin, Eva M Asensio-Marquez, Jose J Garcia-Medina, Maria D Pinazo-Duran, Oscar Coltell, Jose M Ordovas, Dolores Corella
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have been reported, few studies have analyzed their additive effects. We investigated, in a southern European Mediterranean population, the association between relevant POAG polymorphisms, identified by initial genome-wide association studies (GWASs) and POAG risk, both separately and as an aggregated multi-locus genetic risk score (GRS)...
November 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29083408/exome-wide-association-study-of-plasma-lipids-in-300-000-individuals
#14
Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David C M Liewald, Li An Lin, Allan Linneberg, Ruth J F Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas G D Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin N A Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter W F Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Joanna M M Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD...
December 2017: Nature Genetics
https://www.readbyqxmd.com/read/29080057/sex-differences-in-blood-hdl-c-the-total-cholesterol-hdl-c-ratio-and-palmitoleic-acid-are-not-associated-with-variants-in-common-candidate-genes
#15
Shannon L Klingel, Kaitlin Roke, Bertha Hidalgo, Stella Aslibekyan, Robert J Straka, Ping An, Michael A Province, Paul N Hopkins, Donna K Arnett, Jose M Ordovas, Chao-Qiang Lai, David M Mutch
Blood lipids are associated with cardiovascular disease (CVD) risk. Moreover, circulating lipid and fatty acid levels vary between men and women, and evidence demonstrates these traits may be influenced by single nucleotide polymorphisms (SNP). Sex-genotype interactions related to blood lipids and fatty acids have been poorly investigated and may help elucidate sex differences in CVD risk. The goal of this study was to investigate if the influence of SNPs previously associated with blood lipids and fatty acids varies in a sex-specific manner...
December 2017: Lipids
https://www.readbyqxmd.com/read/28982495/the-importance-of-breakfast-in-atherosclerosis-disease-insights-from-the-pesa-study
#16
Irina Uzhova, Valentín Fuster, Antonio Fernández-Ortiz, José M Ordovás, Javier Sanz, Leticia Fernández-Friera, Beatriz López-Melgar, José M Mendiguren, Borja Ibáñez, Héctor Bueno, José L Peñalvo
BACKGROUND: Daily habits, including the number and quality of eating occasions, are potential targets for primary prevention strategies with large health impacts. Skipping breakfast is considered a frequent and unhealthy habit associated with an increased cardiovascular (CV) risk. OBJECTIVES: The study sought to explore the association between different breakfast patterns and CV risk factors and the presence, distribution, and extension of subclinical atherosclerosis...
October 10, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28970513/hdl-cholesterol-efflux-normalised-to-apoa-i-is-associated-with-future-development-of-type-2-diabetes-from-the-cordioprev-trial
#17
Ruth Blanco-Rojo, Pablo Perez-Martinez, Javier Lopez-Moreno, Javier Martinez-Botas, Javier Delgado-Lista, Ben van-Ommen, Elena Yubero-Serrano, Antonio Camargo, Jose M Ordovas, Francisco Perez-Jimenez, Diego Gomez-Coronado, Jose Lopez-Miranda
This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28941034/genome-wide-interactions-with-dairy-intake-for-body-mass-index-in-adults-of-european-descent
#18
Caren E Smith, Jack L Follis, Hassan S Dashti, Toshiko Tanaka, Mariaelisa Graff, Amanda M Fretts, Tuomas O Kilpeläinen, Mary K Wojczynski, Kris Richardson, Mike A Nalls, Christina-Alexandra Schulz, Yongmei Liu, Alexis C Frazier-Wood, Esther van Eekelen, Carol Wang, Paul S de Vries, Vera Mikkilä, Rebecca Rohde, Bruce M Psaty, Torben Hansen, Mary F Feitosa, Chao-Qiang Lai, Denise K Houston, Luigi Ferruci, Ulrika Ericson, Zhe Wang, Renée de Mutsert, Wendy H Oddy, Ester A L de Jonge, Ilkka Seppälä, Anne E Justice, Rozenn N Lemaitre, Thorkild I A Sørensen, Michael A Province, Laurence D Parnell, Melissa E Garcia, Stefania Bandinelli, Marju Orho-Melander, Stephen S Rich, Frits R Rosendaal, Craig E Pennell, Jessica C Kiefte-de Jong, Mika Kähönen, Kristin L Young, Oluf Pedersen, Stella Aslibekyan, Jerome I Rotter, Dennis O Mook-Kanamori, M Carola Zillikens, Olli T Raitakari, Kari E North, Kim Overvad, Donna K Arnett, Albert Hofman, Terho Lehtimäki, Anne Tjønneland, André G Uitterlinden, Fernando Rivadeneira, Oscar H Franco, J Bruce German, David S Siscovick, L Adrienne Cupples, José M Ordovás
SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed...
February 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28939642/dietary-fat-modulation-of-hepatic-lipase-variant-514-c-t-for-lipids-a-crossover-randomized-dietary-intervention-trial-in-caribbean-hispanics
#19
C E Smith, M I Van Rompay, J Mattei, J F Garcia, B Garcia-Bailo, A H Lichtenstein, K L Tucker, J M Ordovás
The hepatic lipase (LIPC) locus is a well-established determinant of high-density lipoprotein cholesterol (HDL-C) concentrations, an association that is modified by dietary fat in observational studies. Dietary interventions are lacking. We investigated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized crossover design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in individuals of Caribbean Hispanic descent (n = 42, 4 wk/phase). No significant gene-diet interactions were observed for HDL-C...
October 1, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28870422/quantitative-evaluation-of-capillaroscopic-microvascular-changes-in-patients-with-established-coronary-heart-disease
#20
M Esther Sanchez-Garcia, Irene Ramirez-Lara, Francisco Gomez-Delgado, Elena M Yubero-Serrano, Ana Leon-Acuña, Carmen Marin, Juan F Alcala-Diaz, Antonio Camargo, Javier Lopez-Moreno, Pablo Perez-Martinez, Francisco José Tinahones, Jose M Ordovas, Javier Caballero, Angeles Blanco-Molina, Jose Lopez-Miranda, Javier Delgado-Lista
INTRODUCTION AND OBJECTIVES: Microcirculation disturbances have been associated to most of the cardiovascular risk factors as well as to multiple inflammatory diseases. However, whether these abnormalities are specifically augmented in patients with coronary heart disease is still unknown. We aimed to evaluate if there is a relationship between the presence of coronary heart disease and the existence of functional and structural capillary abnormalities evaluated in the cutaneous microcirculation by videocapillaroscopy...
September 1, 2017: Medicina Clínica
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