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RANDOMIZED CONTROLLED TRIAL
Johanna H M Stroeve, Edoardo Saccenti, Jildau Bouwman, Adrie Dane, Katrin Strassburg, Jacques Vervoort, Thomas Hankemeier, Arne Astrup, Age K Smilde, Ben van Ommen, Wim H M Saris
OBJECTIVE: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. METHODS: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low-calorie diet (800 kcal) for 8 weeks. Men (N = 236) and women (N = 431) as well as groups with overweight/obesity and morbid obesity were studied separately. The relation between the metabolic status before weight loss and weight loss was assessed by stepwise regression on multiple data sets, including anthropometric parameters, NMR-based plasma metabolites, and LC-MS-based plasma lipid species...
February 2016: Obesity
#22
JOURNAL ARTICLE
Ben van Ommen, Suzan Wopereis
Current biomarkers used in health care and in nutrition and health research are based on quantifying disease onset and its progress. Yet, both health care and nutrition should focus on maintaining optimal health, where the related biology is essentially differing from biomedical science. Health is characterized by the ability to continuously adapt in varying circumstances where multiple mechanisms of systems flexibility are involved. A new generation of biomarkers is needed that quantifies all aspects of systems flexibility, opening the door to real lifestyle-related health optimization, self-empowerment, and related products and services...
2016: Nestlé Nutrition Institute Workshop Series
#23
JOURNAL ARTICLE
Ruth Blanco-Rojo, Juan F Alcala-Diaz, Suzan Wopereis, Pablo Perez-Martinez, Gracia M Quintana-Navarro, Carmen Marin, Jose M Ordovas, Ben van Ommen, Francisco Perez-Jimenez, Javier Delgado-Lista, Jose Lopez-Miranda
AIMS/HYPOTHESIS: The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function. METHODS: The study was performed in 642 patients included in The effect of an olive oil rich Mediterranean diet on type 2 diabetes mellitus risk and incidence study (CORDIOPREV-DIAB). A total of 327 patients were randomised to a Mediterranean diet (35% fat; 22% from monounsaturated fatty acids) and 315 to a low-fat diet (<28% fat)...
January 2016: Diabetologia
#24
JOURNAL ARTICLE
Alwine F M Kardinaal, Marjan J van Erk, Alice E Dutman, Johanna H M Stroeve, Evita van de Steeg, Sabina Bijlsma, Teake Kooistra, Ben van Ommen, Suzan Wopereis
Metabolism maintains homeostasis at chronic hypercaloric conditions, activating postprandial response mechanisms, which come at the cost of adaptation processes such as energy storage, eventually with negative health consequences. This study quantified the metabolic adaptation capacity by studying challenge response curves. After a high-fat challenge, the 8 h response curves of 61 biomarkers related to adipose tissue mass and function, systemic stress, metabolic flexibility, vascular health, and glucose metabolism was compared between 3 metabolic health stages: 10 healthy men, before and after 4 wk of high-fat, high-calorie diet (1300 kcal/d extra), and 9 men with metabolic syndrome (MetS)...
November 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#25
JOURNAL ARTICLE
Johanna H M Stroeve, Herman van Wietmarschen, Bas H A Kremer, Ben van Ommen, Suzan Wopereis
Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life challenges. Physiology acts as a well-orchestrated machinery to adapt to the continuously changing environment. We term this adaptive capacity "phenotypic flexibility." The phenotypic flexibility concept implies that health can be measured by the ability to adapt to conditions of temporary stress, such as physical exercise, infections or mental stress, in a healthy manner...
May 2015: Genes & Nutrition
#26
REVIEW
Daniel J Raiten, Fayrouz A Sakr Ashour, A Catharine Ross, Simin N Meydani, Harry D Dawson, Charles B Stephensen, Bernard J Brabin, Parminder S Suchdev, Ben van Ommen
An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers...
May 2015: Journal of Nutrition
#27
JOURNAL ARTICLE
Elisabeth M van Leeuwen, Lennart C Karssen, Joris Deelen, Aaron Isaacs, Carolina Medina-Gomez, Hamdi Mbarek, Alexandros Kanterakis, Stella Trompet, Iris Postmus, Niek Verweij, David J van Enckevort, Jennifer E Huffman, Charles C White, Mary F Feitosa, Traci M Bartz, Ani Manichaikul, Peter K Joshi, Gina M Peloso, Patrick Deelen, Freerk van Dijk, Gonneke Willemsen, Eco J de Geus, Yuri Milaneschi, Brenda W J H Penninx, Laurent C Francioli, Androniki Menelaou, Sara L Pulit, Fernando Rivadeneira, Albert Hofman, Ben A Oostra, Oscar H Franco, Irene Mateo Leach, Marian Beekman, Anton J M de Craen, Hae-Won Uh, Holly Trochet, Lynne J Hocking, David J Porteous, Naveed Sattar, Chris J Packard, Brendan M Buckley, Jennifer A Brody, Joshua C Bis, Jerome I Rotter, Josyf C Mychaleckyj, Harry Campbell, Qing Duan, Leslie A Lange, James F Wilson, Caroline Hayward, Ozren Polasek, Veronique Vitart, Igor Rudan, Alan F Wright, Stephen S Rich, Bruce M Psaty, Ingrid B Borecki, Patricia M Kearney, David J Stott, L Adrienne Cupples, J Wouter Jukema, Pim van der Harst, Eric J Sijbrands, Jouke-Jan Hottenga, Andre G Uitterlinden, Morris A Swertz, Gert-Jan B van Ommen, Paul I W de Bakker, P Eline Slagboom, Dorret I Boomsma, Cisca Wijmenga, Cornelia M van Duijn
Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of The Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10(-4)), including a rare missense variant in ABCA6 (rs77542162, p...
March 9, 2015: Nature Communications
#28
JOURNAL ARTICLE
Thomas Kelder, Georg Summer, Martien Caspers, Evert M van Schothorst, Jaap Keijer, Loes Duivenvoorde, Susanne Klaus, Anja Voigt, Laura Bohnert, Catalina Pico, Andreu Palou, M Luisa Bonet, Aldona Dembinska-Kiec, Malgorzata Malczewska-Malec, Beata Kieć-Wilk, Josep M Del Bas, Antoni Caimari, Lluis Arola, Marjan van Erk, Ben van Ommen, Marijana Radonjic
Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity-from molecular, to physiological, to social. Understanding and quantification of these interactions will aid design of successful health interventions. We introduce the reference network concept as a platform for multi-level exploration of biological relations relevant for metabolic health, by integration and mining of biological interactions derived from public resources and context-specific experimental data...
January 2015: Genes & Nutrition
#29
JOURNAL ARTICLE
Thomas Kelder, Lars Verschuren, Ben van Ommen, Alain J van Gool, Marijana Radonjic
BACKGROUND: Multifactorial diseases such as type 2 diabetes mellitus (T2DM), are driven by a complex network of interconnected mechanisms that translate to a diverse range of complications at the physiological level. To optimally treat T2DM, pharmacological interventions should, ideally, target key nodes in this network that act as determinants of disease progression. RESULTS: We set out to discover key nodes in molecular networks based on the hepatic transcriptome dataset from a preclinical study in obese LDLR-/- mice recently published by Radonjic et al...
September 11, 2014: BMC Systems Biology
#30
JOURNAL ARTICLE
Niek C A van de Pas, Johan A C Rullmann, Ruud A Woutersen, Ben van Ommen, Ivonne M C M Rietjens, Albert A de Graaf
We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including plasma HDL and non-HDL cholesterol. A pravastatin pharmacokinetic model was constructed and the simulated hepatic pravastatin concentration was used to modulate the reaction rate constant of hepatic free cholesterol synthesis in the PBK model...
August 2014: Journal of Pharmacokinetics and Pharmacodynamics
#31
JOURNAL ARTICLE
Ben van Ommen, Jan van der Greef, Jose Maria Ordovas, Hannelore Daniel
Metabolic adaptation to a disturbance of homeostasis is determined by a series of interconnected physiological processes and molecular mechanisms that can be followed in space (i.e., different organs or organelles) and in time. The amplitudes of these responses of this "systems flexibility network" determine to what extent the individual can adequately react to external challenges of varying nature and thus determine the individual's health status and disease predisposition. Connected pathways and regulatory networks act as "adaptive response systems" with metabolic and inflammatory processes as a core-but embedded into psycho-neuro-endocrine control mechanisms that in their totality define the phenotypic flexibility in an individual...
September 2014: Genes & Nutrition
#32
JOURNAL ARTICLE
Lars Verschuren, Peter Y Wielinga, Thomas Kelder, Marijana Radonjic, Kanita Salic, Robert Kleemann, Ben van Ommen, Teake Kooistra
BACKGROUND: Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic subjects. This study sought to understand the pathophysiological and molecular mechanisms underlying the disparate cardiovascular effects of rosiglitazone and pioglitazone and yield knowledge as to the causative nature of rosiglitazone-associated cardiac hypertrophy...
June 17, 2014: BMC Medical Genomics
#33
RANDOMIZED CONTROLLED TRIAL
Daniël B van Schalkwijk, Albert A de Graaf, Evgeni Tsivtsivadze, Laurence D Parnell, Bianca J C van der Werff-van der Vat, Ben van Ommen, Jan van der Greef, José M Ordovás
BACKGROUND: Cardiovascular disease risk increases when lipoprotein metabolism is dysfunctional. We have developed a computational model able to derive indicators of lipoprotein production, lipolysis, and uptake processes from a single lipoprotein profile measurement. This is the first study to investigate whether lipoprotein metabolism indicators can improve cardiovascular risk prediction and therapy management. METHODS AND RESULTS: We calculated lipoprotein metabolism indicators for 1981 subjects (145 cases, 1836 controls) from the Framingham Heart Study offspring cohort in which NMR lipoprotein profiles were measured...
2014: PloS One
#34
REVIEW
Joanne R Lupton, Stephanie A Atkinson, Namsoo Chang, Cesar G Fraga, Joseph Levy, Mark Messina, David P Richardson, Ben van Ommen, Yuexin Yang, James C Griffiths, John Hathcock
Bioactives can be defined as: "Constituents in foods or dietary supplements, other than those needed to meet basic human nutritional needs, which are responsible for changes in health status" (Office of Disease Prevention and Health Promotion, Office of Public Health and Science, Department of Health and Human Services in Fed Reg 69:55821-55822, 2004). Although traditional nutrients, such as vitamins, minerals, protein, essential fatty acids and essential amino acids, have dietary reference intake (DRI) values, there is no such evaluative process for bioactives...
April 2014: European Journal of Nutrition
#35
REVIEW
Dulce Calçada, Dario Vianello, Enrico Giampieri, Claudia Sala, Gastone Castellani, Albert de Graaf, Bas Kremer, Ben van Ommen, Edith Feskens, Aurelia Santoro, Claudio Franceschi, Jildau Bouwman
Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness...
March 2014: Mechanisms of Ageing and Development
#36
JOURNAL ARTICLE
Jim Kaput, Ben van Ommen, Bas Kremer, Corrado Priami, Jacqueline Pontes Monteiro, Melissa Morine, Fre Pepping, Zoey Diaz, Michael Fenech, Yiwu He, Ruud Albers, Christian A Drevon, Chris T Evelo, Robert E W Hancock, Carel Ijsselmuiden, L H Lumey, Anne-Marie Minihane, Michael Muller, Chiara Murgia, Marijana Radonjic, Bruno Sobral, Keith P West
Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum's one gene-one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems' responses has only become available over the past decade and remains costly...
January 2014: Genes & Nutrition
#37
COMPARATIVE STUDY
Kai Ye, Marian Beekman, Eric-Wubbo Lameijer, Yanju Zhang, Matthijs H Moed, Erik B van den Akker, Joris Deelen, Jeanine J Houwing-Duistermaat, Dennis Kremer, Seyed Yahya Anvar, Jeroen F J Laros, David Jones, Keiran Raine, Ben Blackburne, Shobha Potluri, Quan Long, Victor Guryev, Ruud van der Breggen, Rudi G J Westendorp, Peter A C 't Hoen, Johan den Dunnen, Gert Jan B van Ommen, Gonneke Willemsen, Steven J Pitts, David R Cox, Zemin Ning, Dorret I Boomsma, P Eline Slagboom
It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erroneous proteins to cause an error catastrophe hampered any firm conclusions on these theories. In this study, we sequenced the whole genome of DNA in whole blood of two pairs of monozygotic (MZ) twins, 40 and 100 years old, by two independent next-generation sequencing (NGS) platforms (Illumina and Complete Genomics)...
December 2013: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
#38
JOURNAL ARTICLE
Filippo Castiglione, Paolo Tieri, Albert De Graaf, Claudio Franceschi, Pietro Liò, Ben Van Ommen, Claudia Mazzà, Alexander Tuchel, Massimo Bernaschi, Clare Samson, Teresa Colombo, Gastone C Castellani, Miriam Capri, Paolo Garagnani, Stefano Salvioli, Viet Anh Nguyen, Ivana Bobeldijk-Pastorova, Shaji Krishnan, Aurelio Cappozzo, Massimo Sacchetti, Micaela Morettini, Marc Ernst
BACKGROUND: Type 2 diabetes mellitus (T2D) is a common age-related disease, and is a major health concern, particularly in developed countries where the population is aging, including Europe. The multi-scale immune system simulator for the onset of type 2 diabetes (MISSION-T2D) is a European Union-funded project that aims to develop and validate an integrated, multilevel, and patient-specific model, incorporating genetic, metabolic, and nutritional data for the simulation and prediction of metabolic and inflammatory processes in the onset and progression of T2D...
2013: JMIR Research Protocols
#39
JOURNAL ARTICLE
Suzan Wopereis, Danielle Wolvers, Marjan van Erk, Michiel Gribnau, Bas Kremer, Ferdi A van Dorsten, Esther Boelsma, Ursula Garczarek, Nicole Cnubben, Leon Frenken, Paul van der Logt, Henk F J Hendriks, Ruud Albers, John van Duynhoven, Ben van Ommen, Doris M Jacobs
BACKGROUND: Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress responses. Challenge models may thus be a sensitive measure to study the body's health. The objective of this study was to select a dietary challenge model for the assessment of inflammatory resilience. Meals are a challenge to metabolic homeostasis and are suggested to affect inflammatory pathways, yet data in literature are limited and inconsistent...
2013: BMC Medical Genomics
#40
REVIEW
Mandy Claessens, Laura Contor, Rosalie Dhonukshe-Rutten, Lisette C P G M De Groot, Susan J Fairweather-Tait, Mirjana Gurinovic, Berthold Koletzko, Ben Van Ommen, Monique M Raats, Pieter Van't Veer
The EURopean micronutrient RECommendations Aligned (EURRECA) Network of Excellence (NoE) explored an approach for setting micronutrient recommendations, which would address the variation in recommendations across Europe. Therefore, a framework for deriving and using micronutrient Dietary Reference Values (DRVs) has been developed. This framework comprises four stages (defining the problem-monitoring and evaluating-deriving dietary reference values-using dietary reference values in policy making). The aim of the present paper is to use this framework to identify specific research gaps and needs related to (1) knowledge available on specific micronutrients (folate, iodine, iron, selenium, vitamin B12, vitamin D, and zinc) and (2) the methodology presented in the framework...
2013: Critical Reviews in Food Science and Nutrition
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