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Ben van ommen

Rodrigo San-Cristobal, Santiago Navas-Carretero, Katherine M Livingstone, Carlos Celis-Morales, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Christina P Lambrinou, George Moschonis, Cyril F M Marsaux, Yannis Manios, Miroslaw Jarosz, Hannelore Daniel, Eileen R Gibney, Lorraine Brennan, Christian A Drevon, Thomas E Gundersen, Mike Gibney, Wim H M Saris, Julie A Lovegrove, Keith Grimaldi, Laurence D Parnell, Jildau Bouwman, Ben Van Ommen, John C Mathers, J Alfredo Martinez
Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months...
October 11, 2017: Nutrients
Ruth Blanco-Rojo, Pablo Perez-Martinez, Javier Lopez-Moreno, Javier Martinez-Botas, Javier Delgado-Lista, Ben van-Ommen, Elena Yubero-Serrano, Antonio Camargo, Jose M Ordovas, Francisco Perez-Jimenez, Diego Gomez-Coronado, Jose Lopez-Miranda
This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator...
October 2, 2017: Scientific Reports
Ben van Ommen, Tim van den Broek, Iris de Hoogh, Marjan van Erk, Eugene van Someren, Tanja Rouhani-Rankouhi, Joshua C Anthony, Koen Hogenelst, Wilrike Pasman, André Boorsma, Suzan Wopereis
Personalized nutrition is fast becoming a reality due to a number of technological, scientific, and societal developments that complement and extend current public health nutrition recommendations. Personalized nutrition tailors dietary recommendations to specific biological requirements on the basis of a person's health status and goals. The biology underpinning these recommendations is complex, and thus any recommendations must account for multiple biological processes and subprocesses occurring in various tissues and must be formed with an appreciation for how these processes interact with dietary nutrients and environmental factors...
August 1, 2017: Nutrition Reviews
Suzan Wopereis, Johanna H M Stroeve, Annette Stafleu, Gertruud C M Bakker, Jacobus Burggraaf, Marjan J van Erk, Linette Pellis, Ruud Boessen, Alwine A F Kardinaal, Ben van Ommen
BACKGROUND: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A systematic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). This study aimed to prove that PFT modulates all relevant processes governing metabolic health thereby allowing to distinguish subjects with different metabolic health status...
2017: Genes & Nutrition
Jarlei Fiamoncini, Andrianos M Yiorkas, Kurt Gedrich, Milena Rundle, Sanne I Alsters, Guus Roeselers, Tim J van den Broek, Thomas Clavel, Ilias Lagkouvardos, Suzan Wopereis, Gary Frost, Ben van Ommen, Alexandra I Blakemore, Hannelore Daniel
Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr, mean ± SE) were enrolled into a 12-wk weight loss intervention. All subjects underwent an oral glucose tolerance test and a mixed-meal tolerance test before and after the intervention...
October 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
Pablo Pérez-Martínez, Dimitri P Mikhailidis, Vasilios G Athyros, Mónica Bullo, Patrick Couture, María I Covas, Lawrence de Koning, Javier Delgado-Lista, Andrés Díaz-López, Christian A Drevon, Ramón Estruch, Katherine Esposito, Montserrat Fitó, Marta Garaulet, Dario Giugliano, Antonio García-Ríos, Niki Katsiki, Genovefa Kolovou, Benoît Lamarche, Maria Ida Maiorino, Guillermo Mena-Sánchez, Araceli Muñoz-Garach, Dragana Nikolic, José M Ordovás, Francisco Pérez-Jiménez, Manfredi Rizzo, Jordi Salas-Salvadó, Helmut Schröder, Francisco J Tinahones, Rafael de la Torre, Ben van Ommen, Suzan Wopereis, Emilio Ros, José López-Miranda
The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the available scientific evidence on the associations between lifestyle changes and MetS and its components is reviewed to derive recommendations for MetS prevention and management. Weight loss through an energy-restricted diet together with increased energy expenditure through physical activity contribute to the prevention and treatment of MetS...
May 1, 2017: Nutrition Reviews
Yannis Manios, George Moschonis, Christina P Lambrinou, Christina Mavrogianni, Lydia Tsirigoti, Ulrich Hoeller, Franz F Roos, Igor Bendik, Manfred Eggersdorfer, Carlos Celis-Morales, Katherine M Livingstone, Cyril F M Marsaux, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Clara Woolhead, Hannah Forster, Marianne C Walsh, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Jacqueline Hallmann, Mirosław Jarosz, Agnieszka Surwiłło, Iwona Traczyk, Christian A Drevon, Ben van Ommen, Keith Grimaldi, John N S Matthews, Hannelore Daniel, J Alfredo Martinez, Julie A Lovegrove, Eileen R Gibney, Lorraine Brennan, Wim H M Saris, Mike Gibney, John C Mathers
PURPOSE: To report the vitamin D status in adults from seven European countries and to identify behavioural correlates. METHODS: In total, 1075 eligible adult men and women from Ireland, Netherlands, Spain, Greece, UK, Poland and Germany, were included in the study. RESULTS: Vitamin D deficiency and insufficiency, defined as 25-hydroxy vitamin D3 (25-OHD3) concentration of <30 and 30-49.9 nmol/L, respectively, were observed in 3.3 and 30...
March 13, 2017: European Journal of Nutrition
Tim J van den Broek, Bas H A Kremer, Marisa Marcondes Rezende, Femke P M Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen, Suzan Wopereis
BACKGROUND: Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a challenge test and monitoring the response of relevant phenotypic processes. In this study, we assessed the correlation of three fat-soluble vitamins, (i...
2017: Genes & Nutrition
Carlos Celis-Morales, Katherine M Livingstone, Cyril Fm Marsaux, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Clara Woolhead, Hannah Forster, Marianne C Walsh, Santiago Navas-Carretero, Rodrigo San-Cristobal, Lydia Tsirigoti, Christina P Lambrinou, Christina Mavrogianni, George Moschonis, Silvia Kolossa, Jacqueline Hallmann, Magdalena Godlewska, Agnieszka Surwillo, Iwona Traczyk, Christian A Drevon, Jildau Bouwman, Ben van Ommen, Keith Grimaldi, Laurence D Parnell, John Ns Matthews, Yannis Manios, Hannelore Daniel, J Alfredo Martinez, Julie A Lovegrove, Eileen R Gibney, Lorraine Brennan, Wim Hm Saris, Mike Gibney, John C Mathers
Background: Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information on individual diet and lifestyle, phenotype and/or genotype would promote larger, more appropriate, and sustained changes in dietary behaviour. Methods: : Adults from seven European countries were recruited to an internet-delivered intervention (Food4Me) and randomized to: (i) conventional dietary advice (control) or to PN advice based on: (ii) individual baseline diet; (iii) individual baseline diet plus phenotype (anthropometry and blood biomarkers); or (iv) individual baseline diet plus phenotype plus genotype (five diet-responsive genetic variants)...
April 1, 2017: International Journal of Epidemiology
Elena M Yubero-Serrano, Javier Delgado-Lista, Juan F Alcala-Diaz, Antonio Garcia-Rios, Ana I Perez-Caballero, Ruth Blanco-Rojo, Francisco Gomez-Delgado, Carmen Marin, Francisco J Tinahones, Javier Caballero, Jose M Ordovas, Ben van Ommen, Francisco Perez-Jimenez, Pablo Perez-Martinez, Jose Lopez-Miranda
BACKGROUND AND AIMS: Patients with coexisting coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular recurrence, however, it is not well established whether they exhibit an increased intima-media thickness of both common carotid arteries (IMT-CC). Furthermore, whether this relationship is inherent to T2DM or depends on glycemic control has not been tested in large cohorts. Our aim was to determine whether clinical categories and/or analytical markers of glucose metabolism control were associated with IMT-CC in CHD patients...
October 2016: Atherosclerosis
Johanna H M Stroeve, Edoardo Saccenti, Jildau Bouwman, Adrie Dane, Katrin Strassburg, Jacques Vervoort, Thomas Hankemeier, Arne Astrup, Age K Smilde, Ben van Ommen, Wim H M Saris
OBJECTIVE: Aim is to predict successful weight loss by metabolic signatures at baseline and to identify which differences in metabolic status may underlie variations in weight loss success. METHODS: In DiOGenes, a randomized, controlled trial, weight loss was induced using a low-calorie diet (800 kcal) for 8 weeks. Men (N = 236) and women (N = 431) as well as groups with overweight/obesity and morbid obesity were studied separately. The relation between the metabolic status before weight loss and weight loss was assessed by stepwise regression on multiple data sets, including anthropometric parameters, NMR-based plasma metabolites, and LC-MS-based plasma lipid species...
February 2016: Obesity
Ben van Ommen, Suzan Wopereis
Current biomarkers used in health care and in nutrition and health research are based on quantifying disease onset and its progress. Yet, both health care and nutrition should focus on maintaining optimal health, where the related biology is essentially differing from biomedical science. Health is characterized by the ability to continuously adapt in varying circumstances where multiple mechanisms of systems flexibility are involved. A new generation of biomarkers is needed that quantifies all aspects of systems flexibility, opening the door to real lifestyle-related health optimization, self-empowerment, and related products and services...
2016: Nestlé Nutrition Institute Workshop Series
Ruth Blanco-Rojo, Juan F Alcala-Diaz, Suzan Wopereis, Pablo Perez-Martinez, Gracia M Quintana-Navarro, Carmen Marin, Jose M Ordovas, Ben van Ommen, Francisco Perez-Jimenez, Javier Delgado-Lista, Jose Lopez-Miranda
AIMS/HYPOTHESIS: The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function. METHODS: The study was performed in 642 patients included in The effect of an olive oil rich Mediterranean diet on type 2 diabetes mellitus risk and incidence study (CORDIOPREV-DIAB). A total of 327 patients were randomised to a Mediterranean diet (35% fat; 22% from monounsaturated fatty acids) and 315 to a low-fat diet (<28% fat)...
October 16, 2015: Diabetologia
Alwine F M Kardinaal, Marjan J van Erk, Alice E Dutman, Johanna H M Stroeve, Evita van de Steeg, Sabina Bijlsma, Teake Kooistra, Ben van Ommen, Suzan Wopereis
Metabolism maintains homeostasis at chronic hypercaloric conditions, activating postprandial response mechanisms, which come at the cost of adaptation processes such as energy storage, eventually with negative health consequences. This study quantified the metabolic adaptation capacity by studying challenge response curves. After a high-fat challenge, the 8 h response curves of 61 biomarkers related to adipose tissue mass and function, systemic stress, metabolic flexibility, vascular health, and glucose metabolism was compared between 3 metabolic health stages: 10 healthy men, before and after 4 wk of high-fat, high-calorie diet (1300 kcal/d extra), and 9 men with metabolic syndrome (MetS)...
November 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Johanna H M Stroeve, Herman van Wietmarschen, Bas H A Kremer, Ben van Ommen, Suzan Wopereis
Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life challenges. Physiology acts as a well-orchestrated machinery to adapt to the continuously changing environment. We term this adaptive capacity "phenotypic flexibility." The phenotypic flexibility concept implies that health can be measured by the ability to adapt to conditions of temporary stress, such as physical exercise, infections or mental stress, in a healthy manner...
May 2015: Genes & Nutrition
Daniel J Raiten, Fayrouz A Sakr Ashour, A Catharine Ross, Simin N Meydani, Harry D Dawson, Charles B Stephensen, Bernard J Brabin, Parminder S Suchdev, Ben van Ommen
An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers...
May 2015: Journal of Nutrition
Elisabeth M van Leeuwen, Lennart C Karssen, Joris Deelen, Aaron Isaacs, Carolina Medina-Gomez, Hamdi Mbarek, Alexandros Kanterakis, Stella Trompet, Iris Postmus, Niek Verweij, David J van Enckevort, Jennifer E Huffman, Charles C White, Mary F Feitosa, Traci M Bartz, Ani Manichaikul, Peter K Joshi, Gina M Peloso, Patrick Deelen, Freerk van Dijk, Gonneke Willemsen, Eco J de Geus, Yuri Milaneschi, Brenda W J H Penninx, Laurent C Francioli, Androniki Menelaou, Sara L Pulit, Fernando Rivadeneira, Albert Hofman, Ben A Oostra, Oscar H Franco, Irene Mateo Leach, Marian Beekman, Anton J M de Craen, Hae-Won Uh, Holly Trochet, Lynne J Hocking, David J Porteous, Naveed Sattar, Chris J Packard, Brendan M Buckley, Jennifer A Brody, Joshua C Bis, Jerome I Rotter, Josyf C Mychaleckyj, Harry Campbell, Qing Duan, Leslie A Lange, James F Wilson, Caroline Hayward, Ozren Polasek, Veronique Vitart, Igor Rudan, Alan F Wright, Stephen S Rich, Bruce M Psaty, Ingrid B Borecki, Patricia M Kearney, David J Stott, L Adrienne Cupples, J Wouter Jukema, Pim van der Harst, Eric J Sijbrands, Jouke-Jan Hottenga, Andre G Uitterlinden, Morris A Swertz, Gert-Jan B van Ommen, Paul I W de Bakker, P Eline Slagboom, Dorret I Boomsma, Cisca Wijmenga, Cornelia M van Duijn
Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of The Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value <6.61 × 10(-4)), including a rare missense variant in ABCA6 (rs77542162, p...
March 9, 2015: Nature Communications
Thomas Kelder, Georg Summer, Martien Caspers, Evert M van Schothorst, Jaap Keijer, Loes Duivenvoorde, Susanne Klaus, Anja Voigt, Laura Bohnert, Catalina Pico, Andreu Palou, M Luisa Bonet, Aldona Dembinska-Kiec, Malgorzata Malczewska-Malec, Beata Kieć-Wilk, Josep M Del Bas, Antoni Caimari, Lluis Arola, Marjan van Erk, Ben van Ommen, Marijana Radonjic
Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity-from molecular, to physiological, to social. Understanding and quantification of these interactions will aid design of successful health interventions. We introduce the reference network concept as a platform for multi-level exploration of biological relations relevant for metabolic health, by integration and mining of biological interactions derived from public resources and context-specific experimental data...
January 2015: Genes & Nutrition
Thomas Kelder, Lars Verschuren, Ben van Ommen, Alain J van Gool, Marijana Radonjic
BACKGROUND: Multifactorial diseases such as type 2 diabetes mellitus (T2DM), are driven by a complex network of interconnected mechanisms that translate to a diverse range of complications at the physiological level. To optimally treat T2DM, pharmacological interventions should, ideally, target key nodes in this network that act as determinants of disease progression. RESULTS: We set out to discover key nodes in molecular networks based on the hepatic transcriptome dataset from a preclinical study in obese LDLR-/- mice recently published by Radonjic et al...
2014: BMC Systems Biology
Niek C A van de Pas, Johan A C Rullmann, Ruud A Woutersen, Ben van Ommen, Ivonne M C M Rietjens, Albert A de Graaf
We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including plasma HDL and non-HDL cholesterol. A pravastatin pharmacokinetic model was constructed and the simulated hepatic pravastatin concentration was used to modulate the reaction rate constant of hepatic free cholesterol synthesis in the PBK model...
August 2014: Journal of Pharmacokinetics and Pharmacodynamics
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