Thomas B Knudsen, Suzanne Compton Fitzpatrick, K Nadira De Abrew, Linda S Birnbaum, Anne Chappelle, George P Daston, Dana C Dolinoy, Alison Elder, Susan Euling, Elaine M Faustman, Kristi Pullen Fedinick, Jill A Franzosa, Derik E Haggard, Laurie Haws, Nicole Kleinstreuer, Germaine M Buck Louis, Donna L Mendrick, Ruthann Rudel, Katerine S Saili, Thaddeus T Schug, Robyn L Tanguay, Alexandra E Turley, Barbara A Wetmore, Kimberly W White, Todd J Zurlinden
FutureTox IV, a Society of Toxicology (SOT) Contemporary Concepts in Toxicology (CCT) workshop, was held in November 2018. Building upon FutureTox I, II, and III, this conference focused on the latest science and technology for in vitro profiling and in silico modeling as it relates to predictive developmental and reproductive toxicity (DART). Publicly available high throughput screening data sets are now available for broad in vitro profiling of bioactivities across large inventories of chemicals. Coupling this vast amount of mechanistic data with a deeper understanding of molecular embryology and post-natal development lays the groundwork for using new approach methodologies (NAMs) to evaluate chemical toxicity, drug efficacy, and safety assessment for embryo-fetal development...
February 8, 2021: Toxicological Sciences: An Official Journal of the Society of Toxicology