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Ahmed el-sohemy

Salma A Abdelmagid, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David W L Ma
BACKGROUND: Trans fatty acids (TFAs) produced from industrial partial hydrogenation of vegetable oils have been the subject of much research regarding their negative effect on the development of chronic diseases, and recommendations to label foods with partially hydrogenated vegetable oils and limit their levels were introduced in Canada in 2003 and 2007, respectively. Our aim was to determine temporal changes in circulating plasma TFAs in a population of young healthy Canadian adults after the introduction of the guidelines...
January 2017: CMAJ Open
David J A Jenkins, Beatrice A Boucher, Fredrick D Ashbury, Margaret Sloan, Patrick Brown, Ahmed El-Sohemy, Anthony J Hanley, Walter Willett, Melanie Paquette, Russell J de Souza, Christopher Ireland, Natalie Kwan, Amy Jenkins, Sathish C Pichika, Nancy Kreiger
BACKGROUND: Dietary recommendations emphasize increased consumption of fruit, vegetables, and whole grain cereals for prevention of chronic disease. OBJECTIVES: This study assessed the effect of dietary advice and/or food provision on body weight and cardiovascular disease risk factors. METHODS: Healthy overweight men (n = 209) and women (n = 710), mean age 44.7 years, body mass index [BMI] 32.4 kg/m(2), were randomized between November 2005 and August 2009 to receive Health Canada's food guide (control, n = 486) or 1 of 3 interventions: dietary advice consistent with both Dietary Approaches to Stop Hypertension (DASH) and dietary portfolio principles (n = 145); weekly food provision reflecting this advice (n = 148); or food delivery plus advice (n = 140)...
March 7, 2017: Journal of the American College of Cardiology
Marilyn C Cornelis, Michael G Tordoff, Ahmed El-Sohemy, Rob M van Dam
Taste intensity and quality affect the liking of foods, and determine food choice and consumption. We aimed to 1) classify commonly consumed foods based on recalled taste intensity for bitter, sweet, salty, sour, and fatty taste, and 2) examine the associations among recalled taste intensity, liking, and habitual consumption of foods. In Stage 1, 62 Canadian adults recalled the taste intensity of 120 common foods. Their responses were used to identify sets of 20-25 foods classified as strongly bitter, sweet, salty, sour or fatty-tasting...
February 1, 2017: Appetite
Chiara Pastrello, Mike Tsay, Rosanne McQuaid, Mark Abovsky, Elisa Pasini, Elize Shirdel, Marc Angeli, Tomas Tokar, Joseph Jamnik, Max Kotlyar, Andrea Jurisicova, Joanne Kotsopoulos, Ahmed El-Sohemy, Igor Jurisica
While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microRNAs in human blood in a large nutrigenomics study cohort and in a randomized dose-controlled trial, finding a significant positive correlation between the daily amount of broccoli consumed and the amount of microRNA in the blood...
2016: Scientific Reports
Raffaele De Caterina, Ahmed El-Sohemy
Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations...
2016: Journal of Nutrigenetics and Nutrigenomics
Candace Doepker, Harris R Lieberman, Andrew Paul Smith, Jennifer D Peck, Ahmed El-Sohemy, Brian T Welsh
The debate on the safety of and regulatory approaches for caffeine continues among various stakeholders and regulatory authorities. This decision-making process comes with significant challenges, particularly when considering the complexities of the available scientific data, making the formulation of clear science-based regulatory guidance more difficult. To allow for discussions of a number of key issues, the North American Branch of the International Life Sciences Institute (ILSI) convened a panel of subject matter experts for a caffeine-focused session entitled "Caffeine: Friend or Foe?," which was held during the 2015 ILSI Annual Meeting...
2016: Annual Review of Food Science and Technology
Andre G Dias, Karen M Eny, Moira Cockburn, Winnie Chiu, Daiva E Nielsen, Lisa Duizer, Ahmed El-Sohemy
BACKGROUND/AIMS: To determine whether variation in the TAS1R2 gene affects sucrose taste perception and sugar intake. METHODS: Participants were men (n = 238) and women (n = 458) aged 20-29 years. A subset (n = 95) with body mass index (BMI) data available completed a sensory analysis study. A food frequency questionnaire assessed dietary intake, and eight polymorphisms were genotyped (rs12033832, rs12137730, rs35874116, rs3935570, rs4920564, rs4920566, rs7513755 and rs9701796)...
2015: Journal of Nutrigenetics and Nutrigenomics
Carly E Visentin, Shannon Masih, Lesley Plumptre, Olga Malysheva, Daiva E Nielsen, Kyoung-Jin Sohn, Anna Ly, Andrea Y Lausman, Howard Berger, Ruth Croxford, Ahmed El-Sohemy, Marie A Caudill, Deborah L O'Connor, Young-In Kim
BACKGROUND: Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects. Genetic variants of choline and one-carbon metabolism may also influence birth outcomes by altering plasma choline concentrations. The effects of maternal ad libitum choline intake during pregnancy and fetal genetic variants on maternal and cord concentrations of choline and its metabolites are unknown. OBJECTIVES: This prospective study sought to assess the effect of 1) maternal dietary choline intake on maternal and cord plasma concentrations of choline and its metabolites, and 2) fetal genetic polymorphisms on cord plasma concentrations...
July 2015: Journal of Nutrition
Salma A Abdelmagid, Shannon E Clarke, Kaitlin Roke, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David Wl Ma
BACKGROUND: There is great interest in the relationship between polyunsaturated fatty acids and health. Yet, the combinatory effect of factors such as sex, ethnicity, genetic polymorphisms and hormonal contraceptives (HC) on the concentrations of these fatty acids is unknown. Therefore, we sought to determine the effects of FADS polymorphisms, and HC use in females, on aggregate desaturase indices (ADI), and plasma docosahexaenoic acid (DHA) concentrations in Caucasian and East Asian males and females...
2015: Nutrition & Metabolism
Joseph Jamnik, Bibiana García-Bailo, Christoph H Borchers, Ahmed El-Sohemy
BACKGROUND: Gluten-free foods have increased in popularity over the past decade and are now being consumed by individuals without celiac disease. However, the physiologic effects of gluten intake in individuals without celiac disease remain unknown. High-abundance plasma proteins involved in inflammation, endothelial function, and other physiologic pathways may represent potential biomarkers of biological effects of gluten intake. OBJECTIVE: The objective was to examine the association between gluten intake and plasma proteomic biomarkers in a population of adults without clinically diagnosed celiac disease...
June 2015: Journal of Nutrition
Salma A Abdelmagid, Shannon E Clarke, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David W L Ma
Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a major gap in establishing such relationships is the lack of accepted fatty acid reference ranges representing healthy individuals. Data on validated FA reference ranges would provide a better understanding of study baseline measures and aid in the evaluation and interpretation of pharmaceutical or dietary interventions. Reference ranges for plasma FA levels have been reported in a few small studies and on a limited number of FA...
2015: PloS One
Ayman Al-Hendy, Michael P Diamond, Ahmed El-Sohemy, Sunil K Halder
CONTEXT: Uterine fibroids (UFs) are the most common benign tumors in premenopausal women. In this study, we evaluated the effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] for the treatment of UFs. OBJECTIVE: To determine the role of 1,25(OH)2D3 on the expression of sex steroid receptors in human UF cells. DESIGN: Human UFs and their adjacent myometrium were analyzed for expression of estrogen receptor (ER)-α, progesterone receptor (PR)-A, and PR-B, as well as members of the steroid receptor coactivator (SRC) family...
April 2015: Journal of Clinical Endocrinology and Metabolism
Daiva E Nielsen, Ahmed El-Sohemy
BACKGROUND: Proponents of consumer genetic tests claim that the information can positively impact health behaviors and aid in chronic disease prevention. However, the effects of disclosing genetic information on dietary intake behavior are not clear. METHODS: A double-blinded, parallel group, 2:1 online randomized controlled trial was conducted to determine the short- and long-term effects of disclosing nutrition-related genetic information for personalized nutrition on dietary intakes of caffeine, vitamin C, added sugars, and sodium...
2014: PloS One
Daiva E Nielsen, Sarah Shih, Ahmed El-Sohemy
BACKGROUND/AIMS: Direct-to-consumer (DTC) genetic tests have facilitated easy access to personal genetic information related to health and nutrition; however, consumer perceptions of the nutritional information provided by these tests have not been evaluated. The objectives of this study were to assess individual perceptions of personalized nutrition and genetic testing and to determine whether a personalized nutrition intervention modifies perceptions. METHODS: A double-blind, parallel-group, randomized controlled trial was conducted among healthy men and women aged 20-35 years (n = 138)...
2014: Journal of Nutrigenetics and Nutrigenomics
Jingzhou Wang, Bibiana García-Bailo, Daiva E Nielsen, Ahmed El-Sohemy
BACKGROUND: The 'Blood-Type' diet advises individuals to eat according to their ABO blood group to improve their health and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association between 'blood-type' diets and biomarkers of cardiometabolic health and whether an individual's ABO genotype modifies any associations...
2014: PloS One
Maude Perreault, Kaitlin Roke, Alaa Badawi, Daiva E Nielsen, Salma A Abdelmagid, Ahmed El-Sohemy, David W L Ma, David M Mutch
Inflammation is a recognized risk factor for the development of chronic diseases, such as type 2 diabetes and atherosclerosis. Evidence suggests that individual fatty acids (FA) may have distinct influences on inflammatory processes. The goal of this study was to conduct a cross-sectional analysis to examine the associations between circulating FA and markers of inflammation in a population of young healthy Canadian adults. FA, high-sensitivity C-reactive protein (hsCRP), and cytokines were measured in fasted plasma samples from 965 young adults (22...
March 2014: Lipids
Bibiana García-Bailo, Mohamed Karmali, Alaa Badawi, Ahmed El-Sohemy
OBJECTIVES: The relationship between vitamin D and cardiometabolic disease risk across ethnic groups is unclear, and it is not known whether the use of hormonal contraceptives (HCs), which affect vitamin D metabolism and are also associated with cardiometabolic disease risk, modifies this relationship. Our objectives were to determine the prevalence of vitamin D deficiency (plasma 25-hydroxyvitamin D [25(OH)D] < 30 nmol/L) to assess seasonal variation in concentrations of 25(OH)D, and to examine whether 25(OH)D is associated with cardiometabolic biomarkers across ethnic groups and across men, female HC nonusers, and female HC users in an ethnically diverse population of young adults living in Canada...
2013: Journal of the American College of Nutrition
Bibiana García-Bailo, Joseph Jamnik, Laura A Da Costa, Alaa Badawi, Ahmed El-Sohemy
BACKGROUND/AIMS: Vitamin D regulates gene transcription by binding to the vitamin D receptor (VDR), potentially affecting cardiometabolic disease risk. However, studies of 25-hydroxyvitamin D [25(OH)D] and cardiometabolic disease are inconsistent. Inconsistencies may result from unaccounted for interactions between VDR genetic variants and 25(OH)D. We examined the effect of 25(OH)D on the association between VDR variants and cardiometabolic disease biomarkers. METHODS: The relationship between 25(OH)D, 24 VDR variants, and 10 cardiometabolic biomarkers was examined in 488 Caucasians aged 20-29 years...
2013: Journal of Nutrigenetics and Nutrigenomics
Kaitlin Roke, Jessica C Ralston, Salma Abdelmagid, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David W L Ma, David M Mutch
INTRODUCTION: Past research has reported that single nucleotide polymorphisms (SNPs) in fatty acid desaturase 1 and 2 (FADS1/2) can influence plasma fatty acid (FA) profiles. Changes in FA profiles are known to influence inflammatory processes; therefore both FA and SNPs in FADS1/2 may affect inflammation. The goals of this study were to (i) examine the relationships between individual n-6 FA and estimates of FA desaturation with circulating high sensitivity C-reactive protein (hsCRP) levels, and (ii) determine whether SNPs in FADS1/2 are associated with changes in hsCRP...
September 2013: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Salma A Abdelmagid, Shannon E Clarke, Jeremy Wong, Kaitlin Roke, Daiva Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David Wl Ma
BACKGROUND: The conjugated linoleic acid isomer cis9trans11 CLA can be endogenously synthesized from trans vaccenic acid (C18:1 t11) via desaturation at the delta 9 position catalyzed by the stearoyl-CoA desaturase 1 (SCD1), also known as delta-9 desaturase (D9D). Diet, hormonal regulation of gene expression and single nucleotide polymorphisms (SNPs) have been implicated in altering circulating levels of fatty acids. Hormonal contraceptives (HC) have also been shown to influence levels of some fatty acids...
2013: Nutrition & Metabolism
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