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Ahmed el-sohemy

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https://www.readbyqxmd.com/read/29905076/genetic-variation-in-9p21-and-the-plasma-proteome
#1
Sara Mahdavi, David J A Jenkins, Christoph H Borchers, Ahmed El-Sohemy
Single nucleotide polymorphisms (SNPs) in the non-coding region of 9p21 have been associated with cardiovascular disease (CVD), but the mechanisms by which these genetic variants contribute to the pathogenesis of CVD remain unknown since no annotated proteins are present in this region of DNA. The objective of the current study was to determine if 9p21 genotypes are associated with distinct plasma proteins in young adults. Subjects were 1,611 young adults aged 20-29 years from the Toronto Nutrigenomics and Health Study (1,098 females and 513 males)...
June 15, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29659952/abo-genotype-does-not-modify-the-association-between-the-blood-type-diet-and-biomarkers-of-cardiometabolic-disease-in-overweight-adults
#2
Jingzhou Wang, Joseph Jamnik, Bibiana García-Bailo, Daiva E Nielsen, David J A Jenkins, Ahmed El-Sohemy
Background: Although 7 million copies of Eat Right 4 Your Type have been sold in >60 languages, there has been a lack of evidence supporting the "blood-type" diet hypothesis. Objective: The present study aimed to examine the validity of this diet in overweight adults. Methods: A total of 973 adults [mean ± SEM age: 44.6 ± 0.4 y; mean ± SEM body mass index (BMI; kg/m2): 32.5 ± 0.2; 758 women, 215 men] were participants of the Toronto Healthy Diet Study...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29509641/caffeine-cyp1a2-genotype-and-endurance-performance-in-athletes
#3
Nanci Guest, Paul Corey, Jason Vescovi, Ahmed El-Sohemy
PURPOSE: Many studies have examined the effect of caffeine on exercise performance, but findings have not always been consistent. The objective of this study was to determine whether variation in the CYP1A2 gene, which affects caffeine metabolism, modifies the ergogenic effects of caffeine in a 10-km cycling time trial. METHODS: Competitive male athletes (n=101; age: 25 ± 4 years) completed the time trial under three conditions: 0, 2 or 4 mg of caffeine per kg body mass, using a split-plot randomized, double-blinded, placebo-controlled design...
March 5, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29484031/-fto-genotype-dietary-protein-intake-and-body-weight-in-a-multiethnic-population-of-young-adults-a-cross-sectional-study
#4
David C Merritt, Joseph Jamnik, Ahmed El-Sohemy
Background: Variation in the fat mass and obesity-associated gene ( FTO ) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake modifies the association between FTO variant rs1558902 and body mass index (BMI) and waist circumference in young adults ( n  = 1491) from the cross-sectional Toronto Nutrigenomics and Health Study. Results: Lifestyle, genetic, anthropometric, and biochemical data were collected and diet was assessed using a Toronto-modified Willett Food Frequency Questionnaire...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29249178/biomarkers-of-cardiometabolic-health-and-nutritional-status-in-individuals-with-positive-celiac-disease-serology
#5
Joseph Jamnik, David Ja Jenkins, Ahmed El-Sohemy
BACKGROUND: Celiac disease (CD) is an autoimmune disorder characterized by damage to the intestinal mucosa and nutrient malabsorption in severe cases. However, it remains unclear whether nutrient deficiencies and other adverse health effects are prevalent in individuals with positive CD serology identified through screening studies. OBJECTIVE: The objective was to determine whether biomarkers of cardiometabolic health and nutritional status differ between those with positive and negative CD serology identified in a screening study of Canadian adults...
March 2018: Nutrition and Health
https://www.readbyqxmd.com/read/28950854/hormonal-contraceptive-use-and-prevalence-of-premenstrual-symptoms-in-a-multiethnic-canadian-population
#6
COMPARATIVE STUDY
Alicia Caroline Jarosz, Joseph Jamnik, Ahmed El-Sohemy
BACKGROUND: Hormonal contraceptive use may be associated with a reduction in some premenstrual symptoms, however, the evidence remains equivocal. The objectives of the present study were to investigate the associations between ethnicity and hormonal contraceptive use with premenstrual symptoms. METHODS: One thousand one hundred two women participating in the Toronto Nutrigenomics and Health Study provided data on their premenstrual symptoms and hormonal contraceptive use...
September 26, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28557684/summaries-of-the-micronutrient-symposium-of-the-2016-meeting-of-the-american-college-of-nutrition
#7
Ahmed El-Sohemy, George J Brewer, Ananda S Prasad
No abstract text is available yet for this article.
May 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28530244/retraction-circulating-plant-mirnas-can-regulate-human-gene-expression-in-vitro
#8
Chiara Pastrello, Mike Tsay, Rosanne McQuaid, Mark Abovsky, Elisa Pasini, Elize Shirdel, Marc Angeli, Tomas Tokar, Joseph Jamnik, Max Kotlyar, Andrea Jurisicova, Joanne Kotsopoulos, Ahmed El-Sohemy, Igor Jurisica
This corrects the article DOI: 10.1038/srep32773.
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446633/lactose-intolerance-lct-13910c-t-genotype-is-associated-with-plasma-25-hydroxyvitamin-d-concentrations-in-caucasians-a-mendelian-randomization-study
#9
Ohood Alharbi, Ahmed El-Sohemy
Background: The LCT -13910C>T gene variant is associated with lactose intolerance (LI) in different ethnic groups. Individuals with LI often limit or avoid dairy consumption, a major dietary source of vitamin D in North America, which may lead to inadequate vitamin D intake. Objective: The objective was to determine the prevalence of genotypes predictive of LI in different ethnic groups living in Canada and to determine whether the LCT genotype is associated with plasma 25(OH)D concentrations. Methods: Blood samples were drawn from a total of 1495 men and women aged 20-29 y from the Toronto Nutrigenomics and Health Study for genotyping and plasma 25(OH)D analysis...
June 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28401129/circulating-concentrations-and-relative-percent-composition-of-trans-fatty-acids-in-healthy-canadian-young-adults-between-2004-and-2010-a-cross-sectional-study
#10
Salma A Abdelmagid, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David W L Ma
BACKGROUND: Trans fatty acids (TFAs) produced from industrial partial hydrogenation of vegetable oils have been the subject of much research regarding their negative effect on the development of chronic diseases, and recommendations to label foods with partially hydrogenated vegetable oils and limit their levels were introduced in Canada in 2003 and 2007, respectively. Our aim was to determine temporal changes in circulating plasma TFAs in a population of young healthy Canadian adults after the introduction of the guidelines...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28254171/effect-of-current-dietary-recommendations-on-weight-loss-and-cardiovascular-risk-factors
#11
RANDOMIZED CONTROLLED TRIAL
David J A Jenkins, Beatrice A Boucher, Fredrick D Ashbury, Margaret Sloan, Patrick Brown, Ahmed El-Sohemy, Anthony J Hanley, Walter Willett, Melanie Paquette, Russell J de Souza, Christopher Ireland, Natalie Kwan, Amy Jenkins, Sathish C Pichika, Nancy Kreiger
BACKGROUND: Dietary recommendations emphasize increased consumption of fruit, vegetables, and whole grain cereals for prevention of chronic disease. OBJECTIVES: This study assessed the effect of dietary advice and/or food provision on body weight and cardiovascular disease risk factors. METHODS: Healthy overweight men (n = 209) and women (n = 710), mean age 44.7 years, body mass index [BMI] 32.4 kg/m2 , were randomized between November 2005 and August 2009 to receive Health Canada's food guide (control, n = 486) or 1 of 3 interventions: dietary advice consistent with both Dietary Approaches to Stop Hypertension (DASH) and dietary portfolio principles (n = 145); weekly food provision reflecting this advice (n = 148); or food delivery plus advice (n = 140)...
March 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27915079/recalled-taste-intensity-liking-and-habitual-intake-of-commonly-consumed-foods
#12
Marilyn C Cornelis, Michael G Tordoff, Ahmed El-Sohemy, Rob M van Dam
Taste intensity and quality affect the liking of foods, and determine food choice and consumption. We aimed to 1) classify commonly consumed foods based on recalled taste intensity for bitter, sweet, salty, sour, and fatty taste, and 2) examine the associations among recalled taste intensity, liking, and habitual consumption of foods. In Stage 1, 62 Canadian adults recalled the taste intensity of 120 common foods. Their responses were used to identify sets of 20-25 foods classified as strongly bitter, sweet, salty, sour or fatty-tasting...
February 1, 2017: Appetite
https://www.readbyqxmd.com/read/27604570/circulating-plant-mirnas-can-regulate-human-gene-expression-in-vitro
#13
Chiara Pastrello, Mike Tsay, Rosanne McQuaid, Mark Abovsky, Elisa Pasini, Elize Shirdel, Marc Angeli, Tomas Tokar, Joseph Jamnik, Max Kotlyar, Andrea Jurisicova, Joanne Kotsopoulos, Ahmed El-Sohemy, Igor Jurisica
While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microRNAs in human blood in a large nutrigenomics study cohort and in a randomized dose-controlled trial, finding a significant positive correlation between the daily amount of broccoli consumed and the amount of microRNA in the blood...
September 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27467525/moving-towards-specific-nutrigenetic-recommendation-algorithms-caffeine-genetic-variation-and-cardiovascular-risk
#14
REVIEW
Raffaele De Caterina, Ahmed El-Sohemy
Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations...
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/26735800/caffeine-friend-or-foe
#15
REVIEW
Candace Doepker, Harris R Lieberman, Andrew Paul Smith, Jennifer D Peck, Ahmed El-Sohemy, Brian T Welsh
The debate on the safety of and regulatory approaches for caffeine continues among various stakeholders and regulatory authorities. This decision-making process comes with significant challenges, particularly when considering the complexities of the available scientific data, making the formulation of clear science-based regulatory guidance more difficult. To allow for discussions of a number of key issues, the North American Branch of the International Life Sciences Institute (ILSI) convened a panel of subject matter experts for a caffeine-focused session entitled "Caffeine: Friend or Foe?," which was held during the 2015 ILSI Annual Meeting...
2016: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/26279452/variation-in-the-tas1r2-gene-sweet-taste-perception-and-intake-of-sugars
#16
Andre G Dias, Karen M Eny, Moira Cockburn, Winnie Chiu, Daiva E Nielsen, Lisa Duizer, Ahmed El-Sohemy
BACKGROUND/AIMS: To determine whether variation in the TAS1R2 gene affects sucrose taste perception and sugar intake. METHODS: Participants were men (n = 238) and women (n = 458) aged 20-29 years. A subset (n = 95) with body mass index (BMI) data available completed a sensory analysis study. A food frequency questionnaire assessed dietary intake, and eight polymorphisms were genotyped (rs12033832, rs12137730, rs35874116, rs3935570, rs4920564, rs4920566, rs7513755 and rs9701796)...
2015: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/25972528/maternal-choline-status-but-not-fetal-genotype-influences-cord-plasma-choline-metabolite-concentrations
#17
Carly E Visentin, Shannon Masih, Lesley Plumptre, Olga Malysheva, Daiva E Nielsen, Kyoung-Jin Sohn, Anna Ly, Andrea Y Lausman, Howard Berger, Ruth Croxford, Ahmed El-Sohemy, Marie A Caudill, Deborah L O'Connor, Young-In Kim
BACKGROUND: Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects. Genetic variants of choline and one-carbon metabolism may also influence birth outcomes by altering plasma choline concentrations. The effects of maternal ad libitum choline intake during pregnancy and fetal genetic variants on maternal and cord concentrations of choline and its metabolites are unknown. OBJECTIVES: This prospective study sought to assess the effect of 1) maternal dietary choline intake on maternal and cord plasma concentrations of choline and its metabolites, and 2) fetal genetic polymorphisms on cord plasma concentrations...
July 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/25914723/ethnicity-sex-fads-genetic-variation-and-hormonal-contraceptive-use-influence-delta-5-and-delta-6-desaturase-indices-and-plasma-docosahexaenoic-acid-concentration-in-young-canadian-adults-a-cross-sectional-study
#18
Salma A Abdelmagid, Shannon E Clarke, Kaitlin Roke, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David Wl Ma
BACKGROUND: There is great interest in the relationship between polyunsaturated fatty acids and health. Yet, the combinatory effect of factors such as sex, ethnicity, genetic polymorphisms and hormonal contraceptives (HC) on the concentrations of these fatty acids is unknown. Therefore, we sought to determine the effects of FADS polymorphisms, and HC use in females, on aggregate desaturase indices (ADI), and plasma docosahexaenoic acid (DHA) concentrations in Caucasian and East Asian males and females...
2015: Nutrition & Metabolism
https://www.readbyqxmd.com/read/25855121/gluten-intake-is-positively-associated-with-plasma-%C3%AE-2-macroglobulin-in-young-adults
#19
Joseph Jamnik, Bibiana García-Bailo, Christoph H Borchers, Ahmed El-Sohemy
BACKGROUND: Gluten-free foods have increased in popularity over the past decade and are now being consumed by individuals without celiac disease. However, the physiologic effects of gluten intake in individuals without celiac disease remain unknown. High-abundance plasma proteins involved in inflammation, endothelial function, and other physiologic pathways may represent potential biomarkers of biological effects of gluten intake. OBJECTIVE: The objective was to examine the association between gluten intake and plasma proteomic biomarkers in a population of adults without clinically diagnosed celiac disease...
June 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/25675440/comprehensive-profiling-of-plasma-fatty-acid-concentrations-in-young-healthy-canadian-adults
#20
Salma A Abdelmagid, Shannon E Clarke, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch, David W L Ma
Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a major gap in establishing such relationships is the lack of accepted fatty acid reference ranges representing healthy individuals. Data on validated FA reference ranges would provide a better understanding of study baseline measures and aid in the evaluation and interpretation of pharmaceutical or dietary interventions. Reference ranges for plasma FA levels have been reported in a few small studies and on a limited number of FA...
2015: PloS One
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