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https://www.readbyqxmd.com/read/27825547/trimethylamine-n-oxide-friend-foe-or-simply-caught-in-the-cross-fire
#1
REVIEW
Clara E Cho, Marie A Caudill
Trimethylamine-N-oxide (TMAO), a gut-derived metabolite, has recently emerged as a candidate risk factor for cardiovascular disease and other adverse health outcomes. However, the relation between TMAO and chronic disease can be confounded by several factors, including kidney function, the gut microbiome, and flavin-containing monooxygenase 3 (FMO3) genotype. Thus, whether TMAO is a causative agent in human disease development and progression, or simply a marker of an underlying pathology, remains inconclusive...
November 4, 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27765800/sex-specific-associations-between-one-carbon-metabolism-indices-and-posttranslational-histone-modifications-in-arsenic-exposed-bangladeshi-adults
#2
Caitlin G Howe, Xinhua Liu, Megan N Hall, Vesna Ilievski, Marie A Caudill, Olga Malysheva, Angela M Lomax-Luu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad N Uddin, Tariqul Islam, Joseph H Graziano, Max Costa, Mary V Gamble
BACKGROUND: Posttranslational histone modifications (PTHMs) are altered by arsenic, an environmental carcinogen. PTHMs are also influenced by nutritional methyl donors involved in one-carbon metabolism (OCM), which may protect against epigenetic dysregulation. METHODS: We measured global levels of three PTHMs, which are dysregulated in cancers (H3K36me2, H3K36me3, H3K79me2), in peripheral blood mononuclear cells (PBMCs) from 324 participants enrolled in the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults...
October 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27733523/perinatal-dietary-choline-deficiency-in-sows-influences-concentrations-of-choline-metabolites-fatty-acids-and-amino-acids-in-milk-throughout-lactation
#3
Austin T Mudd, Lindsey S Alexander, Stacey K Johnson, Caitlyn M Getty, Olga V Malysheva, Marie A Caudill, Ryan N Dilger
BACKGROUND: Choline is essential for synthesis of phospholipids, neurodevelopment, and DNA methylation. It is unknown whether dietary perinatal choline deficiency affects maternal milk composition. OBJECTIVE: We examined whether perinatal maternal dietary choline deficiency influences porcine-milk composition. METHODS: Yorkshire sows were fed choline-deficient (CD) or choline-sufficient (CS) gestation diets [544 or 1887 mg choline/kg dry matter (DM), respectively] from 65 d before to 48 h after parturition and then fed lactation diets (517 or 1591 mg choline/kg DM, respectively) through day 19 of lactation...
October 12, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27707701/moderate-folic-acid-supplementation-and-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-result-in-embryonic-defects-and-abnormal-placental-development
#4
Karen E Christensen, Wenyang Hou, Renata H Bahous, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
BACKGROUND: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of elevated folic acid intake. OBJECTIVES: We investigated the effects of moderate folic acid supplementation on reproductive outcomes and assessed the potential interaction of the supplemented diet with MTHFD1-synthetase (Mthfd1S) deficiency in mice, which is a model for the R653Q variant...
October 5, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27377678/trimethylamine-n-oxide-tmao-response-to-animal-source-foods-varies-among-healthy-young-men-and-is-influenced-by-their-gut-microbiota-composition-a-randomized-controlled-trial
#5
Clara E Cho, Siraphat Taesuwan, Olga V Malysheva, Erica Bender, Nathan F Tulchinsky, Jian Yan, Jessica L Sutter, Marie A Caudill
SCOPE: Trimethylamine-N-oxide (TMAO), a metabolite linked to the gut microbiota, is associated with excess risk of heart disease. We hypothesized that (i) TMAO response to animal source foods would vary among healthy men and (ii) this response would be modified by their gut microbiome. METHODS AND RESULTS: A crossover feeding trial in healthy young men (n = 40) was conducted with meals containing TMAO (fish), its dietary precursors, choline (eggs) and carnitine (beef), and a fruit control...
July 5, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27342765/genetic-impairments-in-folate-enzymes-increase-dependence-on-dietary-choline-for-phosphatidylcholine-production-at-the-expense-of-betaine-synthesis
#6
Ariel B Ganz, Kelsey Shields, Vlad G Fomin, Yusnier S Lopez, Sanjay Mohan, Jessica Lovesky, Jasmine C Chuang, Anita Ganti, Bradley Carrier, Jian Yan, Siraphat Taeswuan, Vanessa V Cohen, Camille C Swersky, Julie A Stover, Gerardo A Vitiello, Olga V Malysheva, Erika Mudrak, Marie A Caudill
Although single nucleotide polymorphisms (SNPs) in folate-mediated pathways predict susceptibility to choline deficiency during severe choline deprivation, it is unknown if effects persist at recommended intakes. Thus, we used stable isotope liquid chromatography-mass spectrometry (LC-MS) methodology to examine the impact of candidate SNPs on choline metabolism in a long-term, randomized, controlled feeding trial among pregnant, lactating, and nonpregnant (NP) women consuming 480 or 930 mg/d choline (22% as choline-d9, with d9 indicating a deuterated trimethyl amine group) and meeting folate-intake recommendations...
October 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27335139/vitamin-d-metabolism-varies-among-women-in-different-reproductive-states-consuming-the-same-intakes-of-vitamin-d-and-related-nutrients
#7
Heyjun Park, Patsy M Brannon, Allyson A West, Jian Yan, Xinyin Jiang, Cydne A Perry, Olga V Malysheva, Saurabh Mehta, Marie A Caudill
BACKGROUND: The impact of the reproductive state on vitamin D metabolism and requirements is uncertain in part because of a lack of studies with controlled dietary intakes of vitamin D and related nutrients. OBJECTIVE: We aimed to quantify the impact of the reproductive state on a panel of vitamin D biomarkers among women of childbearing age consuming equivalent amounts of vitamin D and related nutrients. METHODS: Nested within a feeding study providing 2 doses of choline, healthy pregnant (26-29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant/nonlactating; n = 21) women consumed a single amount of vitamin D (511 ± 48 IU/d: 311 ± 48 IU/d from diet and 200 IU/d as supplemental cholecalciferol) and related nutrients (1...
August 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27052531/supplementation-with-folic-acid-but-not-creatine-increases-plasma-betaine-decreases-plasma-dimethylglycine-and-prevents-a-decrease-in-plasma-choline-in-arsenic-exposed-bangladeshi-adults
#8
Megan N Hall, Caitlin G Howe, Xinhua Liu, Marie A Caudill, Olga Malysheva, Vesna Ilievski, Angela M Lomax-Luu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad N Uddin, Tariqul Islam, Joseph H Graziano, Mary V Gamble
BACKGROUND: Folic acid (FA) supplementation facilitates urinary excretion of arsenic, a human carcinogen. A better understanding of interactions between one-carbon metabolism intermediates may improve the ability to design nutrition interventions that further facilitate arsenic excretion. OBJECTIVE: The objective was to determine if FA and/or creatine supplementation increase choline and betaine and decrease dimethylglycine (DMG). METHODS: We conducted a secondary analysis of the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults (n = 605, aged 24-55 y, 50...
May 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/26537341/maternal-obesity-disrupts-the-methionine-cycle-in-baboon-pregnancy
#9
Peter W Nathanielsz, Jian Yan, Ralph Green, Mark Nijland, Joshua W Miller, Guoyao Wu, Thomas J McDonald, Marie A Caudill
Maternal intake of dietary methyl-micronutrients (e.g. folate, choline, betaine and vitamin B-12) during pregnancy is essential for normal maternal and fetal methionine metabolism, and is critical for important metabolic processes including those involved in developmental programming. Maternal obesity and nutrient excess during pregnancy influence developmental programming potentially predisposing adult offspring to a variety of chronic health problems. In the present study, we hypothesized that maternal obesity would dysregulate the maternal and fetal methionine cycle...
November 2015: Physiological Reports
https://www.readbyqxmd.com/read/26451605/biomarkers-of-nutrition-for-development-folate-review
#10
REVIEW
Lynn B Bailey, Patrick J Stover, Helene McNulty, Michael F Fenech, Jesse F Gregory, James L Mills, Christine M Pfeiffer, Zia Fazili, Mindy Zhang, Per M Ueland, Anne M Molloy, Marie A Caudill, Barry Shane, Robert J Berry, Regan L Bailey, Dorothy B Hausman, Ramkripa Raghavan, Daniel J Raiten
The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-based advice to anyone with an interest in the role of nutrition in health. Specifically, the BOND program provides state-of-the-art information and service with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutrients in body tissues at the individual and population level...
July 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/26108676/folate-mediated-one-carbon-metabolism-genes-and-interactions-with-nutritional-factors-on-colorectal-cancer-risk-women-s-health-initiative-observational-study
#11
Ting-Yuan David Cheng, Karen W Makar, Marian L Neuhouser, Joshua W Miller, Xiaoling Song, Elissa C Brown, Shirley A A Beresford, Yingye Zheng, Elizabeth M Poole, Rachel L Galbraith, David J Duggan, Nina Habermann, Lynn B Bailey, David R Maneval, Marie A Caudill, Adetunji T Toriola, Ralph Green, Cornelia M Ulrich
BACKGROUND: Investigations of folate-mediated one-carbon metabolism (FOCM) genes and gene-nutrient interactions with respect to colorectal cancer (CRC) risk are limited to candidate polymorphisms and dietary folate. This study comprehensively investigated associations between genetic variants in FOCM and CRC risk and whether the FOCM nutrient status modified these associations. METHODS: Two hundred eighty-eight candidate and tagging single-nucleotide polymorphisms (SNPs) in 30 FOCM genes were genotyped for 821 incident CRC case-control matched pairs in the Women's Health Initiative Observational Study cohort...
October 15, 2015: Cancer
https://www.readbyqxmd.com/read/26025328/choline-intakes-exceeding-recommendations-during-human-lactation-improve-breast-milk-choline-content-by-increasing-pemt-pathway-metabolites
#12
RANDOMIZED CONTROLLED TRIAL
Crystal Davenport, Jian Yan, Siraphat Taesuwan, Kelsey Shields, Allyson A West, Xinyin Jiang, Cydne A Perry, Olga V Malysheva, Sally P Stabler, Robert H Allen, Marie A Caudill
Demand for the vital nutrient choline is high during lactation; however, few studies have examined choline metabolism and requirements in this reproductive state. The present study sought to discern the effects of lactation and varied choline intake on maternal biomarkers of choline metabolism and breast milk choline content. Lactating (n=28) and control (n=21) women were randomized to 480 or 930 mg choline/day for 10-12 weeks as part of a controlled feeding study. During the last 4-6 weeks, 20% of the total choline intake was provided as an isotopically labeled choline tracer (methyl-d9-choline)...
September 2015: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/25995278/vitamin-b-12-status-differs-among-pregnant-lactating-and-control-women-with-equivalent-nutrient-intakes
#13
RANDOMIZED CONTROLLED TRIAL
Sajin Bae, Allyson A West, Jian Yan, Xinyin Jiang, Cydne A Perry, Olga Malysheva, Sally P Stabler, Robert H Allen, Marie A Caudill
BACKGROUND: Limited data are available from controlled studies on biomarkers of maternal vitamin B-12 status. OBJECTIVE: We sought to quantify the effects of pregnancy and lactation on the vitamin B-12 status response to a known and highly controlled vitamin B-12 intake. METHODS: As part of a 10-12 wk feeding trial, pregnant (26-29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant, nonlactating; n = 21) women consumed vitamin B-12 amounts of ∼8...
July 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/25972528/maternal-choline-status-but-not-fetal-genotype-influences-cord-plasma-choline-metabolite-concentrations
#14
Carly E Visentin, Shannon Masih, Lesley Plumptre, Olga Malysheva, Daiva E Nielsen, Kyoung-Jin Sohn, Anna Ly, Andrea Y Lausman, Howard Berger, Ruth Croxford, Ahmed El-Sohemy, Marie A Caudill, Deborah L O'Connor, Young-In Kim
BACKGROUND: Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects. Genetic variants of choline and one-carbon metabolism may also influence birth outcomes by altering plasma choline concentrations. The effects of maternal ad libitum choline intake during pregnancy and fetal genetic variants on maternal and cord concentrations of choline and its metabolites are unknown. OBJECTIVES: This prospective study sought to assess the effect of 1) maternal dietary choline intake on maternal and cord plasma concentrations of choline and its metabolites, and 2) fetal genetic polymorphisms on cord plasma concentrations...
July 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/25805190/formate-metabolism-in-fetal-and-neonatal-sheep
#15
Shannon E Washburn, Marie A Caudill, Olga Malysheva, Amanda J MacFarlane, Nathalie A Behan, Brian Harnett, Luke MacMillan, Theerawat Pongnopparat, John T Brosnan, Margaret E Brosnan
By virtue of its role in nucleotide synthesis, as well as the provision of methyl groups for vital methylation reactions, one-carbon metabolism plays a crucial role in growth and development. Formate, a critical albeit neglected component of one-carbon metabolism, occurs extracellularly and may provide insights into cellular events. We examined formate metabolism in chronically cannulated fetal sheep (gestation days 119-121, equivalent to mid-third trimester in humans) and in their mothers as well as in normal full-term lambs...
May 15, 2015: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25733650/high-folic-acid-consumption-leads-to-pseudo-mthfr-deficiency-altered-lipid-metabolism-and-liver-injury-in-mice
#16
Karen E Christensen, Leonie G Mikael, Kit-Yi Leung, Nancy Lévesque, Liyuan Deng, Qing Wu, Olga V Malysheva, Ana Best, Marie A Caudill, Nicholas D E Greene, Rima Rozen
BACKGROUND: Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown. Methylenetetrahydrofolate reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation reactions. OBJECTIVE: Our goal was to investigate the impact of high folic acid intake on liver disease and methyl metabolism. DESIGN: Folic acid-supplemented diet (FASD, 10-fold higher than recommended) and control diet were fed to male Mthfr(+/+) and Mthfr(+/-) mice for 6 mo to assess gene-nutrient interactions...
March 2015: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/25558280/genes-predict-long-distance-migration-and-large-body-size-in-a-migratory-fish-pacific-lamprey
#17
Jon E Hess, Christopher C Caudill, Matthew L Keefer, Brian J McIlraith, Mary L Moser, Shawn R Narum
Elucidation of genetic mechanisms underpinning migratory behavior could help predict how changes in genetic diversity may affect future spatiotemporal distribution of a migratory species. This ability would benefit conservation of one such declining species, anadromous Pacific lamprey (Entosphenus tridentatus). Nonphilopatric migration of adult Pacific lamprey has homogenized population-level neutral variation but has maintained adaptive variation that differentiates groups based on geography, run-timing and adult body form...
December 2014: Evolutionary Applications
https://www.readbyqxmd.com/read/25336191/plasma-choline-metabolites-and-colorectal-cancer-risk-in-the-women-s-health-initiative-observational-study
#18
Sajin Bae, Cornelia M Ulrich, Marian L Neuhouser, Olga Malysheva, Lynn B Bailey, Liren Xiao, Elissa C Brown, Kara L Cushing-Haugen, Yingye Zheng, Ting-Yuan David Cheng, Joshua W Miller, Ralph Green, Dorothy S Lane, Shirley A A Beresford, Marie A Caudill
Few studies have examined associations between plasma choline metabolites and risk of colorectal cancer. Therefore, we investigated associations between plasma biomarkers of choline metabolism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TMAO)] and colorectal cancer risk among postmenopausal women in a case-control study nested within the Women's Health Initiative Observational Study. We selected 835 matched case-control pairs, and cases were further stratified by tumor site (proximal, distal, or rectal) and stage (local/regional or metastatic)...
December 15, 2014: Cancer Research
https://www.readbyqxmd.com/read/25173092/total-and-methyl-mercury-in-whole-blood-measured-for-the-first-time-in-the-u-s-population-nhanes-2011-2012
#19
Mary E Mortensen, Samuel P Caudill, Kathleen L Caldwell, Cynthia D Ward, Robert L Jones
BACKGROUND: Despite the public health and toxicologic interest in methyl mercury (MeHg) and ethyl mercury (EHg), these mercury species have been technically difficult to measure in large population studies. METHODS: Using NHANES 2011-2012 data, we calculated reference ranges and examined demographic factors associated with specific mercury species concentrations and the ratio of MeHg to THg. We conducted several multiple regression analyses to examine factors associated with MeHg concentrations and also with the ratio of MeHg to THg...
October 2014: Environmental Research
https://www.readbyqxmd.com/read/25122647/pregnancy-and-lactation-alter-biomarkers-of-biotin-metabolism-in-women-consuming-a-controlled-diet
#20
RANDOMIZED CONTROLLED TRIAL
Cydne A Perry, Allyson A West, Antoinette Gayle, Lauren K Lucas, Jian Yan, Xinyin Jiang, Olga Malysheva, Marie A Caudill
BACKGROUND: Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women is 30 μg/d, whereas 35 μg/d is recommended for lactating women. However, pregnant and lactating women may require more biotin to meet the demands of these reproductive states. OBJECTIVE: The current study sought to quantify the impact of reproductive state on biotin status response to a known dietary intake of biotin...
December 2014: Journal of Nutrition
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