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Junya Kojima, Masanori Ono, Koichiro Tasaki, Takeshi Nagai, Toshitaka Nagao, Sho Rinno, Yoshihiko Kanno, Rie Yoshida, Tomoo Suzuki, Naoaki Kuji, Hirotaka Nishi
BACKGROUND: Pregnancy-related acute kidney injury (Pr-AKI) is associated with significant maternal and fetal morbidity and mortality, with a three- to four-fold increase in perinatal mortality. Pr-AKI can arise from various obstetric complications, such as hyperemesis gravidarum, septic abortion, hypertensive disorders of pregnancy, pyelonephritis, and antiphospholipid antibody syndrome. Therefore, early diagnosis and appropriate intervention, including the identification of the underlying etiology, are important to effectively manage Pr-AKI...
2024: International Medical Case Reports Journal
#2
JOURNAL ARTICLE
Maki Taniguchi, Haruhiko Kanasaki, Aki Oride, Hiroe Okada, Kayo Imamura, Satoru Kyo
PURPOSE: To examine the association between semen characteristics and outcomes of intrauterine insemination (IUI). METHODS: This retrospective analysis examined 1380 IUI procedures involving 421 couples. The association of clinical pregnancy with pre- and post-wash sperm characteristics was assessed. RESULTS: Pre- and post-wash sperm characteristics did not differ between IUI cycles that resulted in pregnancy and those that did not. When the motility of pre-wash sperm was below the normal range (<42%) established by the World Health Organization (WHO), the pregnancy rate was significantly lower...
2024: Reproductive Medicine and Biology
#3
JOURNAL ARTICLE
H Islam, A Z M Salahuddin, M O F Miah, S P Shanta, M S Hossain, M S I Moon, P Datta, M Hasib, S R Khan
Postpartum acute kidney injury (AKI) is a condition characterized by a sudden and rapid decline in kidney function that occurs shortly after childbirth. Several risk factors may be associated with postpartum acute kidney injury (AKI). Understanding the possible risk factors is essential for timely intervention and improved maternal healthcare. The aim of the study was to assess the risk factors of postpartum acute kidney injury patients. This prospective observational study took place at Mymensingh Medical College Hospital, from March 2020 to April 2021...
April 2024: Mymensingh Medical Journal: MMJ
#4
REVIEW
Paraskevi Eva Andronikidi, Eirini Orovou, Eleftheria Mavrigiannaki, Virginia Athanasiadou, Maria Tzitiridou-Chatzopoulou, George Iatrakis, Eirini Grapsa
Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction. Chronic kidney disease is an established risk factor for the development of pre-eclampsia, as angiogenic homeostasis is altered and the maternal circulation is already hypertensive. Facing pre-eclampsia in the context of chronic kidney disease is a challenging emergency for both the mother and the fetus. The clinical features and the management of this multi-organ disorder are clearly defined in the modern literature but the underlying pathophysiologic mechanisms remain not fully elucidated...
February 27, 2024: International Journal of Molecular Sciences
#5
EDITORIAL
Ilona Hromadnikova
This Special Issue mainly focuses on preeclampsia (PE), haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, gestational diabetes mellitus (GDM), foetal growth restriction (FGR), small-for-gestational-age foetuses (SGA), miscarriage, stillbirth, first-episode psychosis (FEP) during pregnancy, and pregnancy-related acute kidney injury (PR-AKI) [...].
February 20, 2024: International Journal of Molecular Sciences
#6
JOURNAL ARTICLE
Shipra Sandilya, Kumari Usha Rani, Rajesh Kumar
INTRODUCTION: Pregnancy-related acute kidney injury (PRAKI) is acute kidney injury (AKI) occurring during pregnancy, labor, and postpartum period. AKI is defined as suddenly impaired kidney function with the retention of nitrogenous and other waste products. In high population country like India, not all deliveries are done tertiary care. Even not all are registered one if delivery is conducted at a hospital setup. The majority of patients are being managed by available obstetrician at local places...
December 2023: Journal of Family Medicine and Primary Care
#7
JOURNAL ARTICLE
Joana Moscoso, Margarida Serôdio, Ana Rita Prior
We present a case of a male neonate who experienced a 13.5% weight loss at 96 hours of life, despite receiving adequate calorie intake and exhibiting no feeding difficulties. The pregnancy was uneventful, and maternal serological investigation was normal. A routine ultrasound at 34 weeks of gestational age revealed late oligohydramnios. The neonate was delivered at 35 weeks of gestational age by forceps, weighing 2600 g. Physical examination disclosed bilateral cryptorchidism. Laboratory studies unveiled acute kidney injury (AKI) with hyperkalaemia...
February 14, 2024: BMJ Case Reports
#8
JOURNAL ARTICLE
Susan Cheruiyot, Jacob Shabani, Jasmit Shah, Catherine Gathu, Ahmed Sokwala
BACKGROUND: Corona Virus Disease 2019 (COVID-19), an infection caused by the SARS-CoV-2 virus, has been the largest global pandemic since the turn of the 21st century. With emerging research on this novel virus, studies from the African continent have been few. Corona Virus Disease 2019 has been shown to affect various organs including the lungs, gut, nervous system, and the kidneys. Acute kidney injury (AKI) is an independent risk factor for mortality and increases the health care burden for patients with persistent kidney dysfunction and maintenance dialysis...
2024: Canadian Journal of Kidney Health and Disease
#9
Basil Alnasrallah, Eman Alabbad, Mohammed M Aljishi, Zainab A Alkhuraidah, Sumayah Alsabaa
Thrombotic microangiopathy (TMA) is a severe systemic disorder with multiorgan manifestations due to thrombosis of the microvasculature. Pregnancy and post-partum are particularly high-risk periods for many forms of TMA. The disease progression is rapid and can lead to organ failure and even death; therefore, urgent recognition and treatment are paramount. The presence of other triggers such as infections or autoimmune diseases like systematic lupus erythematosus (SLE) can add further complexity, which emphasizes the need for definitive diagnostic investigations such as kidney biopsy to promptly direct further diagnosis and management...
January 2024: Curēus
#10
JOURNAL ARTICLE
Noor Muhammad, Nazia Liaqat
OBJECTIVE: To determine frequencies of causes and renal outcomes of pregnancy related acute kidney injury. METHOD: This descriptive case series study was conducted in Nephrology unit of a tertiary care hospital of Peshawar, from 1st August 2021 to 31st July 2022.A total of 100 patients with acute kidney injury secondary to obstetric conditions were enrolled via non-probability consecutive sampling technique. While patients with pre-existing renal disease, those with renal stones, or having bilateral small kidneys on ultrasound were excluded from the study...
2024: Pakistan Journal of Medical Sciences Quarterly
#11
JOURNAL ARTICLE
Maniyar Iqbal Anvar, Sidhant Talwar, Shashikanth Mallapur
Introduction Acute kidney injury (AKI) significantly contributes to maternal morbidity and mortality in developing nations. In a retrospective study conducted at our tertiary care center in collaboration between the Department of Nephrology and the Department of Obstetrics and Gynecology, we investigated patients admitted with pregnancy-related acute kidney injury (PR-AKI) under the following parameters: incidence, etiology, and maternal outcomes. Methods We evaluated 70 patients admitted with PR-AKI from May 2016 to August 2020...
November 2023: Curēus
#12
REVIEW
Anthony Batte, Lubaba Shahrin, Rolando Claure-Del Granado, Valerie A Luyckx, Andrea L Conroy
Globally, there are an estimated 13.3 million cases of acute kidney injury (AKI) annually. Although infections are a common cause of AKI globally, most infection-associated AKI occurs in low- and lower-middle-income countries. There are marked differences in the etiology of infection-associated AKI across age groups, populations at risk, and geographic location. This article provides a global overview of different infections that are associated commonly with AKI, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human immunodeficiency virus, malaria, dengue, leptospirosis, tick-borne illnesses, and viral hemorrhagic fevers...
December 28, 2023: Seminars in Nephrology
#13
REVIEW
Darryl Wood
Snakebite-related fatalities disproportionately affect populations in impoverished socio-economic regions, marked by limited access to adequate healthcare and constrained antivenom availability. Early medical intervention is pivotal in mitigating mortality and morbidity associated with snakebite envenoming (SBE). While clinical assessment remains fundamental in treating SBE, this review aims to spotlight objective parameters that could also affect outcomes. Selected studies that identify factors associated with poor outcomes are predominantly region-specific, single-site, and observational, yet collectively reveal similar findings...
November 28, 2023: Toxins
#14
JOURNAL ARTICLE
Elli Toivonen, Kirsi Taurio, Eija Kortelainen, Aki S Havulinna, Tiina Jääskeläinen, Hannele Laivuori
BACKGROUND: Centrally collected Finnish national health register data on adverse pregnancy outcomes are available for research, but the validity of the data is largely unknown. Our aim was to compare the diagnoses of preeclampsia (PE), gestational diabetes (GDM), and preterm delivery from hospital records with the registry based diagnoses from the Finnish Care Register for Health Care (FCR). Data on gestational age at delivery from the Medical Birth Registry (MBR) was also studied. METHODS: The Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) Study cohort was used as a data source...
December 12, 2023: Pregnancy Hypertension
#15
Valentina Bruno, David Barth, Arenn Jauhal
RATIONALE: Thrombotic microangiopathy (TMA) is a spectrum of rare diseases characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ damage. Differentiating pre-eclampsia, HELLP (Hemolysis, Elevated Liver enzymes, Low Platelets) syndrome and atypical hemolytic uremic syndrome (aHUS) during pregnancy may be diagnostically challenging yet important as the treatment pathways differ. Most cases of aHUS are associated with dysregulation of the complement alternative pathway, for which current guidelines recommend prompt treatment with complement C5 inhibitor to prevent chronic sequelae...
2023: Canadian Journal of Kidney Health and Disease
#16
JOURNAL ARTICLE
Aki Onishi, Ai Shibata
BACKGROUND: Epidemiological studies on urinary incontinence that used a validated international standard questionnaire are limited in Japan, and few studies have examined the sociodemographic and behavioral correlates of urinary incontinence. OBJECTIVE: The aim of this study was to estimate the prevalence of urinary incontinence according to the Japanese version of the International Consultation on Incontinence Questionnaire-Short Form, and its sociodemographic and behavioral correlates among Japanese women...
2023: Women's Health
#17
JOURNAL ARTICLE
Yogavijayan Kandasamy, Stephanie Baker
A preterm birth is a live birth that occurs before 37 completed weeks of pregnancy. Approximately 15 million babies are born preterm annually worldwide, indicating a global preterm birth rate of about 11%. Up to 50% of premature neonates in the gestational age (GA) group of <29 weeks' gestation will develop acute kidney injury (AKI) in the neonatal period; this is associated with high mortality and morbidity. There are currently no proven treatments for established AKI, and no effective predictive tool exists...
September 5, 2023: Diagnostics
#18
David Westergaard, Valgerdur Steinthorsdottir, Lilja Stefansdottir, Palle Duun Rohde, Xiaoping Wu, Frank Geller, Jaakko Tyrmi, Aki S Havulinna, Pol Sole Navais, Christopher Flatley, Sisse Rye Ostrowski, Ole Birger Pedersen, Christian Erikstrup, Erik Sørensen, Christina Mikkelsen, Mie Topholm Brun, Bitten Aagaard Jensen, Thorsten Brodersen, Henrik Ullum, Per Magnus, Ole A Andreassen, Pål R Njolstad, Astrid Marie Kolte, Lone Krebs, Mette Nyegaard, Thomas Folkmann Hansen, Bjarke Fenstra, Mark Daly, Cecilia M Lindgren, Gudmar Thorleifsson, Olafur A Stefansson, Gardar Sveinbjornsson, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Karina Banasik, Bo Jacobsson, Triin Laisk, Hannele Laivuori, Kari Stefansson, Søren Brunak, Henriette Svarre Nielsen
Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severity of these complications in maternal-fetal health. Here, we investigated the genetic variation underlying aspects of pregnancy-associated bleeding and identified five loci associated with PPH through a meta-analysis of 21,512 cases and 259,500 controls. Functional annotation analysis indicated candidate genes, HAND2 , TBX3 , and RAP2C / FRMD7, at three loci and showed that at each locus, associated variants were located within binding sites for progesterone receptors (PGR)...
August 15, 2023: medRxiv
#19
JOURNAL ARTICLE
Dalia Younis, Alaa Mosbah, Mahmoud M Zakaria, Amira Awadalla, Ghada El-Kannishy, Rasha S Shemies
BACKGROUND: The differentiation between preeclampsia and similarly presenting kidney disease in pregnancy is a diagnostic challenge. Although some laboratory tests have been utilized, globally validated tools are yet needed, particularly in resource-limited settings. Congophilic proteins are abundantly detected in the urine of pregnant women who develop preeclampsia that is thought to be a marker of disease process. The present study aimed to assess the diagnostic and predictive utility of urinary congophilia in pregnant women with hypertensive disorders of pregnancy as well as kidney diseases...
August 15, 2023: Journal of Hypertension
#20
JOURNAL ARTICLE
Mohamed E Elrggal, Divya Bajpai, Elliot Koranteng Tannor, Rabeea Azmat, Ahmed Muhammad Bashir, Justor Banda, Nzana Victorine B, Yannick Mayamba Nlandu, Bala Waziri, Winfred Baah, Rumbidzai Dahwa, Rasha Samir Shemies
Pregnancy-related acute kidney injury (AKI) is a major public health problem with substantial maternal and fetal morbidity and mortality. Women with pregnancy-related AKI require immediate access to nephrology care to prevent deleterious kidney and health outcomes. Patients with pregnancy-related AKI in low-income and lower-middle-income countries experience disparities in access to comprehensive nephrology care for many reasons. In this perspective, we highlight the burden of pregnancy-related AKI and explore the challenges among different low-income and lower-middle-income countries...
September 2023: Kidney medicine
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