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https://www.readbyqxmd.com/read/27909812/in-phyllodes-tumors-of-the-breast-expression-of-sparc-osteonectin-bm40-mrna-by-in-situ-hybridization-correlates-with-protein-expression-by-immunohistochemistry-and-is-associated-with-tumor-progression
#1
Nah Ihm Kim, Ga-Eon Kim, Ji Shin Lee, Min Ho Park
Secreted protein acidic and rich in cysteine (SPARC) plays an essential role in tumor invasion and metastasis. The present work was undertaken to detect expression of SPARC mRNA in phyllodes tumors (PTs) and its association with SPARC protein expression. This study also evaluated expression of SPARC mRNA and its correlation between grade and clinical behavior of PTs. In addition, we assessed in PTs the association of expression of SPARC with that of matrix metalloproteinase (MMP)-2 and of MMP-9. SPARC mRNA expression was determined by RNAscope in situ hybridization (ISH) in 50 benign, 22 borderline, and 10 malignant PTs using a tissue microarray...
December 1, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27897205/coulomb-nanoradiator-mediated-site-specific-thrombolytic-proton-treatment-with-a-traversing-pristine-bragg-peak
#2
Jae-Kun Jeon, Sung-Mi Han, Soon-Ki Min, Seung-Jun Seo, Kyuwook Ihm, Won-Seok Chang, Jong-Ki Kim
Traversing proton beam-irradiated, mid/high-Z nanoparticles produce site-specific enhancement of X-ray photon-electron emission via the Coulomb nanoradiator (CNR) effect, resulting in a nano- to micro-scale therapeutic effect at the nanoparticle-uptake target site. Here, we demonstrate the uptake of iron oxide nanoparticles (IONs) and nanoradiator-mediated, site-specific thrombolysis without damaging the vascular endothelium in an arterial thrombosis mouse model. The enhancement of low-energy electron (LEE) emission and reactive oxygen species (ROS) production from traversing proton beam-irradiated IONs was examined...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893204/estimating-the-economic-burden-of-lung-cancer-in-iran
#3
Satar Rezaei, Ali Akbari Sari, Abraha Woldemichael, Moslem Soofi, Ali Kazemi, Behzad Karami Matin
Objectives: Lung cancer is a major public health problem and one of the most costly illnesses. The study aimed to estimate the economic burden of lung cancer in Iran in 2014. Methods: A cross-sectional study was conducted to estimate the direct and indirect costs for patients with lung cancer using a prevalence-based approach. A human capital approach was employed to estimate the indirect costs. Data were obtained from several sources such as through patient interview using structured questionnaire, medical records, the GLOBOCAN databases, the Iranian Statistical Center, the Iranian Ministry of Cooperation, Labor and Social Welfare, and the Institute for Health Metrics and Evaluation (IHME)...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27876006/predictors-of-in-hospital-mortality-following-major-lower-extremity-amputations-in-type-2-diabetic-patients-using-artificial-neural-networks
#4
Ana Lopez-de-Andres, Valentin Hernandez-Barrera, Roberto Lopez, Pablo Martin-Junco, Isabel Jimenez-Trujillo, Alejandro Alvaro-Meca, Miguel Angel Salinero-Fort, Rodrigo Jimenez-Garcia
BACKGROUND: Outcome prediction is important in the clinical decision-making process. Artificial neural networks (ANN) have been used to predict the risk of post-operative events, including survival, and are increasingly being used in complex medical decision making. We aimed to use ANN analysis to estimate predictive factors of in-hospital mortality (IHM) in patients with type 2 diabetes (T2DM) after major lower extremity amputation (LEA) in Spain. METHODS: We design a retrospective, observational study using ANN models...
November 22, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27875571/short-and-long-term-mortality-rates-of-elderly-acute-kidney-injury-patients-who-underwent-continuous-renal-replacement-therapy
#5
Harin Rhee, Keum Sook Jang, Jong Man Park, Jin Suk Kang, Na Kyoung Hwang, Il Young Kim, Sang Heon Song, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak
BACKGROUND: The world's population is aging faster and the incidence of acute kidney injury (AKI) needing continuous renal replacement therapy (CRRT) is increasing in elderly population. The outcome of AKI needing CRRT in elderly patients is known to be poor. However, the definitions of elderly used in the previous literatures were diverse and, there were few data that compared the long-term mortality rates of these patients with middle aged patients. This study was aimed to evaluate this issue...
2016: PloS One
https://www.readbyqxmd.com/read/27849566/effects-of-sacubitril-valsartan-lcz696-on-natriuresis-diuresis-blood-pressures-and-nt-probnp-in-salt-sensitive-hypertension
#6
Tzung-Dau Wang, Ru-San Tan, Hae-Young Lee, Sang-Hyun Ihm, Moo-Yong Rhee, Brian Tomlinson, Parasar Pal, Fan Yang, Elizabeth Hirschhorn, Margaret F Prescott, Markus Hinder, Thomas H Langenickel
: Salt-sensitive hypertension (SSH) is characterized by impaired sodium excretion and subnormal vasodilatory response to salt loading. Sacubitril/valsartan (LCZ696) was hypothesized to increase natriuresis and diuresis and result in superior blood pressure control compared with valsartan in Asian patients with SSH. In this randomized, double-blind, crossover study, 72 patients with SSH received sacubitril/valsartan 400 mg and valsartan 320 mg once daily for 4 weeks each. SSH was diagnosed if the mean arterial pressure increased by ≥10% when patients switched from low (50 mmol/d) to high (320 mmol/d) sodium diet...
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27846297/trends-in-epidemiology-of-copd-in-hiv-infected-patients-in-spain-1997-2012
#7
Javier de Miguel-Díez, Ana López-de-Andrés, Rodrigo Jiménez-García, Luis Puente-Maestu, Isabel Jiménez-Trujillo, Valentín Hernández-Barrera, Salvador Resino, Alejandro Álvaro-Meca
PURPOSE: The aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997-2012). METHODS: A retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection)...
2016: PloS One
https://www.readbyqxmd.com/read/27845545/burden-of-sexually-transmitted-infections-in-iran-from-1990-to-2010-results-from-the-global-burden-of-disease-study-2010
#8
Shadi Rahimzadeh, Shohreh Naderimagham, Marzieh Rohani-Rasaf, Parinaz Mehdipour, Masoud Lotfizadeh, Sharareh R Niakan Kalhori, Fereshteh Davoudi, Atefeh Noori, Kianoush Kamali, Seyed Saeed Hashemi Nazari
BACKGROUND: The present study describes the epidemiological status of sexually transmitted infections (STIs) in Iran based on the Global Burden of Disease study 2010 (the GBD 2010), and compares this with those of other neighboring countries. METHODS: The burden of STIs from 1990 to 2010 in Iran was derived from a systematic study, namely the GBD 2010, which was conducted by the Institute for Health Metrics and Evaluation (IHME). Using a model-based estimation, Disability Adjusted Life Years (DALYs) were calculated on the basis of the prevalence of STIs...
November 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27843053/prehypertension-is-associated-with-early-complications-of-atherosclerosis-but-not-with-exercise-capacity
#9
Mi-Hyang Jung, Sang-Hyun Ihm, Dong-Hyeon Lee, Woo-Baek Chung, Hae Ok Jung, Ho-Joong Youn
BACKGROUND: Prehypertension has a high risk of progression to hypertension, and intensive lifestyle modification including regular exercise is recommended for the management of prehypertensive individuals. However, data on the association between exercise capacity and hypertension status are limited. Therefore, we aimed 1) to define the characteristics of prehypertension, focusing on metabolic aspects and exercise capacity, and 2) to elucidate determinants of exercise capacity in healthy individuals without hypertension...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27822930/the-association-between-parameters-of-socioeconomic-status-and-hypertension-in-korea-the-korean-genome-and-epidemiology-study
#10
Chan Soon Park, Kyoung Hwa Ha, Hyeon Chang Kim, Sungha Park, Sang Hyun Ihm, Hae Young Lee
We investigated the association between socioeconomic status and hypertension in Korea, a country that has experienced a dynamic socioeconomic transition. We analyzed participants of a prospective cohort study-the Korean Genome and Epidemiology Study-enrolled between 2001 and 2003. We recruited 7,089 subjects who underwent a 4-year follow up till 2007. Education and income levels, which are important parameters for socioeconomic status, were stratified into 4 groups. Education level was defined as short (≤ 6 years), mid-short (7-9 years), mid-long (10-12 years), and long (≥ 12 years)...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27788233/the-predictive-role-of-serum-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-according-to-renal-function-in-patients-with-acute-myocardial-infarction
#11
Jin Sug Kim, Weon Kim, Jong Shin Woo, Tae Won Lee, Chun Gyoo Ihm, Yang Gyoon Kim, Joo Young Moon, Sang Ho Lee, Myung Ho Jeong, Kyung Hwan Jeong
OBJECTIVE: A high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported as an independent predictor for cardiovascular events in the general population. However, the prognostic value of this ratio in patients with renal dysfunction is unclear. We examined the association of the TG/HDL-C ratio with major adverse cardiovascular events (MACEs) according to renal function in patients with acute myocardial infarction (AMI). METHOD: This study was based on the Korea Acute Myocardial Infarction Registry database...
2016: PloS One
https://www.readbyqxmd.com/read/27776285/oxygen-generating-hybrid-nanoparticles-to-enhance-fluorescent-photoacoustic-ultrasound-imaging-guided-tumor-photodynamic-therapy
#12
Shi Gao, Guohao Wang, Zainen Qin, Xiangyu Wang, Guoqing Zhao, Qingjie Ma, Lei Zhu
Photodynamic therapy (PDT) is a promising tumor treatment modality that can convert oxygen into cytotoxic singlet oxygen (SO) via photosensitizer to ablate tumor growth. However, the uncontrolled cancer cell proliferation during tumor development and the oxygen consumption during PDT always result in an insufficient oxygen level in tumors, which can adversely affect the PDT efficiency in turn. We designed an oxygen-generating PDT nanocomplex by encapsulating a manganese dioxide nanoparticle (MnO2 NP) in an indocyanine green (ICG) modified hyaluronic acid nanoparticle (HANP) to overcome this limitation...
October 19, 2016: Biomaterials
https://www.readbyqxmd.com/read/27766447/relationship-between-%C3%AE-amyloid-and-mitochondrial-dynamics
#13
Dah Ihm Kim, Ki Hoon Lee, Ji Young Oh, Jun Sung Kim, Ho Jae Han
Mitochondria as dynamic organelles undergo morphological changes through the processes of fission and fusion which are major factors regulating their functions. A disruption in the balance of mitochondrial dynamics induces functional disorders in mitochondria such as failed energy production and the generation of reactive oxygen species, which are closely related to pathophysiological changes associated with Alzheimer's disease (AD). Recent studies have demonstrated a relationship between abnormalities in mitochondrial dynamics and impaired mitochondrial function, clarifying the effects of morphofunctional aberrations which promote neuronal cell death in AD...
October 20, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27766249/a-potential-issue-with-screening-prediabetes-or-diabetes-using-serum-glucose-a-delay-in-diagnosis
#14
Jun Goo Kang, Cheol-Young Park, Sung-Hee Ihm, Sung Woo Park
The aim of this study was to compare the fasting serum glucose level with the fasting plasma glucose level for diagnosing hyperglycemic states in real-life clinical situations. Additionally, we investigated a usual delay in sample processing and how such delays can impact the diagnosis of hyperglycemic states. Among 1,254 participants who had normoglycemia or impaired fasting glucose (IFG) assessed by the fasting serum glucose level, 20.9% were newly diagnosed with diabetes based on the plasma fasting glucose level...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27754058/os-15-06-sequential-activation-of-intrarenal-ace-ace2-as-the-progression-of-hypertensive-nephropathy-in-2-kidney-10clip-2k1c-goldblatt-rats
#15
Yang Gyun Kim, Sangho Lee, Ju Young Moon, Se Yeon Kim, Yu Ho Lee, Seok Jong Song, Kyung Whan Jeoung, Tae Won Lee, Chun Gyu Ihm
OBJECTIVE: Intrarenal renin-angiotensin system (RAS) had an important role to generate and maintain hypertension in 2-kidny 1-clip (2K1C) rats. This study purposed to assess how various intrarenal RAS components of 2K1C rats contributed to hypertension in different parts (cortex, medulla) of both sides (CK; clipped-kidney, NCK; non-clipped kidney) at different times (2 weeks; 2w and 5 weeks; 5w after clipping operation). DESIGN AND METHOD: We conducted to insert clip to left renal artery or sham operation to SD rats, then systolic blood pressure (SBP) was measured at one week interval...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753949/os-07-05-determinants-of-morning-blood-pressure-surge-in-normotensive-subjects-and-untreated-hypertensive-patients-the-korean-ambulatory-blood-pressure-multicenter-observational-study
#16
Jeong-Eun Yi, Wook Bum Pyun, Yoonpyo Lee, Junbeom Park, Gee Yeon Kim, Sang-Hyun Ihm, Ju Han Kim, Soon Kil Kim, Gil Ja Shin
OBJECTIVE: Morning blood pressure (BP) surge has been regarded as a predictor of adverse cardiovascular events. However, its determinants remain controversial and no previous studies have evaluated whether or not there is a difference in the determinants of morning BP surge between normotensive and hypertensive subjects. DESIGN AND METHOD: We included 476 normotensive subjects (mean age 52.8 ± 15.4 years, 49.2% males) and 1028 untreated hypertensive patients (age 51...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753896/os-01-05-high-aldosterone-renin-ratio-arr-is-associated-with-the-development-of-essential-hypertension-from-white-coat-hypertension
#17
Ami Kwon, Woo-Baek Chung, Tae-Hoon Kim, Suk Min Suh, Eun Ho Chu, Sung-Won Jang, GeeHee Kim, Sang Hyun Ihm
OBJECTIVE: There are many reports about white coat hypertension (WCH), still the clinical significance and pathophysiology of WCH is ambiguous. The aim of this study was to find out the difference of RAAS activity in WCH compared with the essential hypertension (EH) group, which could suggest the role of RAAS activity in the development of WCH. DESIGN AND METHOD: Never treated hypertension patients who visited 8 hospitals of The Catholic University of Korea from January 2011 through July 2012 were enrolled...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733323/open-versus-laparoscopic-cholecystectomies-in-patients-with-or-without-type-2-diabetes-mellitus-in-spain-from-2003-to-2013
#18
Jose M de Miguel-Yanes, Manuel Mendez-Bailon, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Napoleon Perez-Farinos, Fernando Turegano, Nuria Munoz-Rivas, Ana Lopez-de-Andres
BACKGROUND: This study aimed to compare the rates of open and laparoscopic cholecystectomies and outcomes in patients with or without type 2 diabetes mellitus (T2DM) in Spain from 2003 to 2013. METHODS: We collected all cases of open and laparoscopic cholecystectomies using national hospital discharge data and evaluated the annual cholecystectomy rates stratified by T2DM status. We analyzed tendency for in-hospital mortality (IHM). We also analyzed the impact of T2DM on IHM in patients who underwent cholecystectomies...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27730263/-prevention-of-overweight-in-children-standard-setting-documents
#19
Gesine Bär, Michael Noweski, Maria Ihm, Anja Voss
BACKGROUND: The quality of preventive measures is an essential precondition for their success. A current objective of health policy in Germany is to find the criteria for quality, as well as to process and discuss them systematically with relevant stakeholders. OBJECTIVES: An assessment of the quality standards of overweight prevention in children was the main objective of the study. Scientific articles and standard-setting documents of purchasers and providers of measures were analyzed...
October 11, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27699232/the-antifibrotic-drug-pirfenidone-promotes-pulmonary-cavitation-and-drug-resistance-in-a-mouse-model-of-chronic-tuberculosis
#20
Bintou A Ahidjo, Mariama C Maiga, Elizabeth A Ihms, Mamoudou Maiga, Alvaro A Ordonez, Laurene S Cheung, Sarah Beck, Bruno B Andrade, Sanjay Jain, William R Bishai
Pirfenidone is a recently approved antifibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). Because tuberculosis (TB) is characterized by granulomatous inflammation in conjunction with parenchymal destruction and replacement fibrosis, we sought to determine whether the addition of pirfenidone as an adjunctive, host-directed therapy provides a beneficial effect during antimicrobial treatment of TB. We hypothesized that pirfenidone's antiinflammatory and antifibrotic properties would reduce inflammatory lung damage and increase antimicrobial drug penetration in granulomas to accelerate treatment response...
September 8, 2016: JCI Insight
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