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Jose M de Miguel-Yanes, Manuel Mendez-Bailon, Rodrigo Jimenez-Garcia, Valentin Hernandez-Barrera, Napoleon Perez-Farinos, Fernando Turegano, Nuria Munoz-Rivas, Ana Lopez-de-Andres
BACKGROUND: This study aimed to compare the rates of open and laparoscopic cholecystectomies and outcomes in patients with or without type 2 diabetes mellitus (T2DM) in Spain from 2003 to 2013. METHODS: We collected all cases of open and laparoscopic cholecystectomies using national hospital discharge data and evaluated the annual cholecystectomy rates stratified by T2DM status. We analyzed tendency for in-hospital mortality (IHM). We also analyzed the impact of T2DM on IHM in patients who underwent cholecystectomies...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Gesine Bär, Michael Noweski, Maria Ihm, Anja Voss
BACKGROUND: The quality of preventive measures is an essential precondition for their success. A current objective of health policy in Germany is to find the criteria for quality, as well as to process and discuss them systematically with relevant stakeholders. OBJECTIVES: An assessment of the quality standards of overweight prevention in children was the main objective of the study. Scientific articles and standard-setting documents of purchasers and providers of measures were analyzed...
October 11, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Bintou A Ahidjo, Mariama C Maiga, Elizabeth A Ihms, Mamoudou Maiga, Alvaro A Ordonez, Laurene S Cheung, Sarah Beck, Bruno B Andrade, Sanjay Jain, William R Bishai
Pirfenidone is a recently approved antifibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). Because tuberculosis (TB) is characterized by granulomatous inflammation in conjunction with parenchymal destruction and replacement fibrosis, we sought to determine whether the addition of pirfenidone as an adjunctive, host-directed therapy provides a beneficial effect during antimicrobial treatment of TB. We hypothesized that pirfenidone's antiinflammatory and antifibrotic properties would reduce inflammatory lung damage and increase antimicrobial drug penetration in granulomas to accelerate treatment response...
September 8, 2016: JCI Insight
Na Kyoung Hwang, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Chang Won Kim, Sang Heon Song
We encountered three cases of retroperitoneal hematoma caused by spontaneous lumbar artery rupture, a rare vascular complication. At the time of retroperitoneal hematoma, two patients were on anticoagulant/antiplatelet therapy. One patient was not taking any anticoagulant/antiplatelet agents but was receiving hemodialysis treatment with heparin. Lumbar artery rupture was successfully controlled by transcatheter arterial embolization in all patients, but one patient developed multiple organ failure and died...
September 26, 2016: Hemodialysis International
Shengcun Ma, Yiqun Gan, Baiyang Chen, Zhong Tang, Stuart Krasner
This study systematically evaluates the capabilities of five types of household water treatment (HWT) methods (including boiler heating, microwave irradiation, pouring, stirring, and shaking) on the removals of four regulated trihalomethanes (THM4) and three iodinated halomethanes (IHMs) under a variety of conditions simulative of residential uses. Overall, the results clearly showed promising capabilities of all five HWT methods in controlling volatile disinfection by-products (DBPs), and heating with a boiler was the most effective approach among all methods due to the synergistic effects of water turbulence and bubbling phenomena...
August 22, 2016: Journal of Hazardous Materials
Yu Ho Lee, Jin Sug Kim, Se-Yun Kim, Yang Gyun Kim, Ju-Young Moon, Kyung-Hwan Jeong, Tae Won Lee, Chun-Gyoo Ihm, Sang-Ho Lee
BACKGROUND: Endocan, previously called endothelial cell-specific molecule-1, is a soluble proteoglycan that is secreted from vascular endothelial cells. Elevated plasma endocan levels were shown to be associated with poor cardiovascular outcomes in patients with chronic kidney disease (CKD). We investigated the clinical relevance of plasma and urine endocan levels in patients with immunoglobulin A nephropathy (IgAN). METHODS: Sixty-four patients with IgAN and 20 healthy controls were enrolled in this study...
September 2016: Kidney Research and Clinical Practice
Ji-Hoon Lee, Shin Yeong Lee, Jin Sug Kim, Da Rae Kim, Su Woong Jung, Kyung Hwan Jeong, Tae Won Lee, Yoo Ho Lee, Yang Gyun Kim, Ju Young Moon, Sang Ho Lee, Chun Gyoo Ihm
BACKGROUND: Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular diseases. The aim of this study was to explore the association between serum IgE levels and renal outcome in patients with immunoglobulin A nephropathy (IgAN). METHODS: We included 117 patients with biopsy-proven IgAN...
September 2016: Kidney Research and Clinical Practice
Jeong-Eun Yi, Wook Bum Pyun, Yoonpyo Lee, Junbeom Park, Gee Yeon Kim, Sang-Hyun Ihm, Ju Han Kim, Soon Kil Kim, Gil Ja Shin
OBJECTIVE: Morning blood pressure (BP) surge has been regarded as a predictor of adverse cardiovascular events. However, its determinants remain controversial and no previous studies have evaluated whether or not there is a difference in the determinants of morning BP surge between normotensive and hypertensive subjects. DESIGN AND METHOD: We included 476 normotensive subjects (mean age 52.8 ± 15.4 years, 49.2% males) and 1028 untreated hypertensive patients (age 51...
September 2016: Journal of Hypertension
Ami Kwon, Woo-Baek Chung, Tae-Hoon Kim, Suk Min Suh, Eun Ho Chu, Sung-Won Jang, GeeHee Kim, Sang Hyun Ihm
OBJECTIVE: There are many reports about white coat hypertension (WCH), still the clinical significance and pathophysiology of WCH is ambiguous. The aim of this study was to find out the difference of RAAS activity in WCH compared with the essential hypertension (EH) group, which could suggest the role of RAAS activity in the development of WCH. DESIGN AND METHOD: Never treated hypertension patients who visited 8 hospitals of The Catholic University of Korea from January 2011 through July 2012 were enrolled...
September 2016: Journal of Hypertension
Yang Gyun Kim, Sangho Lee, Ju Young Moon, Se Yeon Kim, Yu Ho Lee, Seok Jong Song, Kyung Whan Jeoung, Tae Won Lee, Chun Gyu Ihm
OBJECTIVE: Intrarenal renin-angiotensin system (RAS) had an important role to generate and maintain hypertension in 2-kidny 1-clip (2K1C) rats. This study purposed to assess how various intrarenal RAS components of 2K1C rats contributed to hypertension in different parts (cortex, medulla) of both sides (CK; clipped-kidney, NCK; non-clipped kidney) at different times (2 weeks; 2w and 5 weeks; 5w after clipping operation). DESIGN AND METHOD: We conducted to insert clip to left renal artery or sham operation to SD rats, then systolic blood pressure (SBP) was measured at one week interval...
September 2016: Journal of Hypertension
Gema Sánchez-Muñoz, Ana López de Andrés, Rodrigo Jiménez-García, Pilar Carrasco-Garrido, Valentín Hernández-Barrera, Fernando Pedraza-Serrano, Luis Puente-Maestu, Javier de Miguel-Díez
OBJECTIVE: To analyze changes in the incidence, diagnostic procedures, comorbidity, length of hospital stay (LOHS), costs and in-hospital mortality (IHM) for patients with bronchiectasis who were hospitalized in Spain over a 10-year period. METHODS: We included all admissions for patients diagnosed with bronchiectasis as primary or secondary diagnosis during 2004-2013. RESULTS: 282,207 patients were admitted to the study. After controlling for possible confounders, we observed a significant increase in the incidence of hospitalizations over the study period when bronchiectasis was a secondary diagnosis...
2016: PloS One
Jang-Hee Cho, Hye-Myung Ryu, Eun-Joo Oh, Ju-Min Yook, Ji-Sun Ahn, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Ihm Soo Kwak, Chan-Duck Kim
Alpha1-antitrypsin (AAT) exerts its anti-inflammatory effect through regulating the activity of serine proteinases. This study evaluated the inhibitory effects of AAT against the transforming growth factor (TGF)-β1 induced epithelial-to-mesenchymal transition (EMT) in unilateral ureter obstruction (UUO) mice and Madin-Darby canine kidney (MDCK) cells. C57BL/6 mice with induced UUO were injected intraperitoneally with AAT (80 mg/Kg) or vehicle for 7 days. MDCK cells were treated with TGF-β1 (2 ng/mL) for 48 hours to induce EMT, and co-treated with AAT (10 mg/mL) to inhibit the EMT...
2016: PloS One
Dah Ihm Kim, Ki Hoon Lee, Amr Ahmed Gabr, Gee Euhn Choi, Jun Sung Kim, So Hee Ko, Ho Jae Han
Mitochondrial dysfunction is known as one of causative factors in Alzheimer's disease (AD), inducing neuronal cell death. Mitochondria regulate their functions through changing their morphology. The present work was undertaken to investigate whether Amyloid β (Aβ) affects mitochondrial morphology in neuronal cells to induce apoptosis. Aβ treatment induced not only the fragmentation of mitochondria but also neuronal apoptosis in association with an increase in caspase-9 and -3 activity. Calcium influx induced by Aβ up-regulated the activation of Akt through CaMKII resulting in changes to the phosphorylation level of Drp1 in a time-dependent manner...
September 3, 2016: Biochimica et Biophysica Acta
Shinwon Lee, Sun Hee Lee, Jeong Ha Mok, Su Jin Lee, Kye Hyung Kim, Jeong Eun Lee, Seung Geun Lee, Joo Seop Chung, Ihm Soo Kwak
The epidemiological synergy between human immunodeficiency virus (HIV) and tuberculosis (TB) is a major threat to public health. However, the association between HIV and multi-drug resistant tuberculosis (MDR-TB) is not clear. To explore the association between HIV and MDR-TB infection, a case-control study was performed in Korea. A total of 1606 culture-proven TB patients (45 HIV vs. 1561 non-HIV) from January 2006 to October 2014 were included in this analysis. MDR-TB rates were 11.1% and 8.2% in the HIV and non-HIV groups, respectively (p=0...
November 2016: Yonsei Medical Journal
Uisoo Chae, Jin Young Min, Sung Hoon Kim, Hyo Jin Ihm, Young Sang Oh, So Yun Park, Hee Dong Chae, Chung Hoon Kim, Byung Moon Kang
PURPOSE: Progesterone resistance is thought to be a major factor that contributes to progression of endometriosis. However, it is not clear what causes progesterone resistance in endometriosis. This study aimed to assess whether cytokines or peritoneal fluid can affect progesterone receptor (PR) expression in endometrial cells and to verify whether PR expression is reduced in endometriosis. MATERIALS AND METHODS: The PR-B/A ratio was measured via real-time polymerase chain reaction after in vitro culture, in which endometrial cells were treated with either tumor necrosis factor-alpha (TNF-α), interleukin-1 beta, or peritoneal fluid obtained from women with advanced-stage endometriosis...
November 2016: Yonsei Medical Journal
Alejandro Alvaro-Meca, Rodrigo Jiménez-Garcia, Isabel Jimenez-Trujillo, Valentin Hernandez-Barrera, Javier de Miguel-Diez, Salvador Resino, Ana Lopez-de-Andres
OBJECTIVE: To describe trends in the prevalence of diabetes among hospitalized HIV-infected patients between 1997 and 2012 in Spain and compare them with those of age- and sex-matched non-HIV-infected patients. METHODS: The study was based on Spanish national hospital discharge data. We performed a retrospective study for the period 1997-2012. HIV infection (HIV-infected versus non-HIV-infected [control group])and calendar period in relation to widespread use of combination antiretroviral therapy (cART) (1997-1999; 2000-2003; 2004-2007 and 2008-2012), were the exposure variables The outcome variables were diagnosis of diabetes and in-hospital mortality (IHM)...
2016: PloS One
Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee, Sung-Hee Ihm
AIMS: To examine the correlation between the fasting plasma glucose and HbA1c levels using regression equation and to assess the average fasting plasma glucose levels for the specific HbA1c (A1C) goals in the patients with diabetes using each A1C-and fasting plasma glucose-based diagnostic criteria. METHODS: This study included data from 4481 participants with A1C and fasting plasma glucose, but with no diabetic medications in the Korean National Health and Nutritional Examination Survey 2011...
2016: Diabetology & Metabolic Syndrome
Victoria Pillay-van Wyk, William Msemburi, Ria Laubscher, Rob E Dorrington, Pam Groenewald, Tracy Glass, Beatrice Nojilana, Jané D Joubert, Richard Matzopoulos, Megan Prinsloo, Nadine Nannan, Nomonde Gwebushe, Theo Vos, Nontuthuzelo Somdyala, Nomfuneko Sithole, Ian Neethling, Edward Nicol, Anastasia Rossouw, Debbie Bradshaw
BACKGROUND: The poor health of South Africans is known to be associated with a quadruple disease burden. In the second National Burden of Disease (NBD) study, we aimed to analyse cause of death data for 1997-2012 and develop national, population group, and provincial estimates of the levels and causes of mortality. METHOD: We used underlying cause of death data from death notifications for 1997-2012 obtained from Statistics South Africa. These data were adjusted for completeness using indirect demographic techniques for adults and comparison with survey and census estimates for child mortality...
September 2016: Lancet Global Health
P Boutouyrie, F Elmula, P Rebora, A Talvik, S Salerno, E Miszkowska-Nagorna, X Liuc, T Comotti, A Larstorp, M Rostrup, E Qwierblewska, M Valsecchi, S E Kjeldsen, M Viigimaa, K Narkiewicz, G Parati, S Laurent
OBJECTIVE: In the BEAUTY study we investigated whether utilizing non-invasive monitoring of hemodynamic parameters by thoracic impedance plethysmography (IHM) combined with a drug selection algorithm (DSA) compared to conventional drug selection may improve uncontrolled hypertension in European Hypertension Excellence Centres. Although the results of the BEAUTY study on ABPM were neutral (J Hypertens 2015), we investigated whether IHM-DSA could favourably influence central BP and arterial stiffness...
September 2016: Journal of Hypertension
Beomyong Hwang, Jeongwoon Hwang, Jong Keon Yoon, Sungjun Lim, Sungmin Kim, Minjun Lee, Jeong Hoon Kwon, Hongwoo Baek, Dongchul Sung, Gunn Kim, Suklyun Hong, Jisoon Ihm, Joseph A Stroscio, Young Kuk
Securing a semiconducting bandgap is essential for applying graphene layers in switching devices. Theoretical studies have suggested a created bulk bandgap in a graphene layer by introducing an asymmetry between the A and B sub-lattice sites. A recent transport measurement demonstrated the presence of a bandgap in a graphene layer where the asymmetry was introduced by placing a graphene layer on a hexagonal boron nitride (h-BN) substrate. Similar bandgap has been observed in graphene layers on metal substrates by local probe measurements; however, this phenomenon has not been observed in graphene layers on a near-insulating substrate...
2016: Scientific Reports
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