keyword
MENU ▼
Read by QxMD icon Read
search

Ihme

keyword
https://www.readbyqxmd.com/read/28346848/cardiovascular-protective-effects-and-clinical-applications-of-resveratrol
#1
Sanghyun Cho, Kyung Namkoong, Minji Shin, Jueun Park, Eunyeong Yang, Jinsoo Ihm, Vu Thi Thu, Hyoung Kyu Kim, Jin Han
Resveratrol is a naturally occurring phenol that is generated by plant species following injury or attack by bacterial and fungal pathogens. This compound was first described as the French Paradox in 1992. Later in 2003, resveratrol was reported to activate sirtuins in yeast cells. Recent experimental studies have found that resveratrol offers a variety of benefits that include both anticarcinogenic and anti-inflammatory effects in addition to the ability to reverse obesity, attenuate hyperglycemia and hyperinsulinemia, protect heart and endothelial function, and increase the life span...
March 27, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28342632/the-pharmacodynamics-of-low-and-standard-doses-of-ticagrelor-in-patients-with-end-stage-renal-disease-on-hemodialysis
#2
Jin Sug Kim, Jong Shin Woo, Jin Bae Kim, Woo-Shik Kim, Tae Won Lee, Kwon Sam Kim, Chun Gyoo Ihm, Weon Kim, Kyung Hwan Jeong
BACKGROUND: Patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) respond poorly to clopidogrel. We assessed the utility of low-dose ticagrelor in ESRD patients on maintenance HD. METHODS: In this single-center, prospective, randomized pharmacodynamic study, 52 ESRD patients on HD were prescribed clopidogrel (300mg loading dose [LD], then 75mg daily), standard-dose ticagrelor (180mg LD, then 90mg twice daily), or low-dose ticagrelor (90mg LD, then 90mg daily) for 14days...
March 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28326327/ameliorating-effect-of-gemigliptin-on-renal-injury-in-murine-adriamycin-induced-nephropathy
#3
Da Rae Kim, Shin Yeong Lee, Jin Sug Kim, Yang Gyun Kim, Ju-Young Moon, Sang Ho Lee, Tae Won Lee, Chun Gyoo Ihm, Kyung Hwan Jeong
Background. Previous studies have shown the antiapoptotic and anti-inflammatory potential of DPP-IV inhibitor in experimental models of renal injury. We tested whether DPP-IV inhibitor (gemigliptin) ameliorates renal injury by suppressing apoptosis, inflammation, and oxidative stress in mice with adriamycin nephropathy. Methods. Mice were treated with normal saline (control), gemigliptin (GM), adriamycin (ADR), or adriamycin combined with gemigliptin (ADR+GM). Apoptosis, inflammation, and oxidative stress were analyzed via western blotting, real-time PCR, light microscopy, and immunofluorescence...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28306496/use-of-magnetic-resonance-imaging-guided-biopsy-of-a-vertebral-body-mass-to-diagnose-osteosarcoma-in-a-rottweiler
#4
Rebecca A Krimins, Jan Fritz, Larry A Gainsburg, Patrick R Gavin, Elizabeth A Ihms, David L Huso, Dara L Kraitchman
CASE DESCRIPTION A 9-year-old spayed female Rottweiler with hind limb ataxia was examined because of anorexia and an acute onset of hind limb paresis. CLINICAL FINDINGS Neurologic evaluation revealed hind limb ataxia and symmetric paraparesis with bilaterally abnormal hind limb postural reactions including hopping, hemiwalking, hemistanding, and delayed proprioception, which were suggestive of a lesion somewhere in the T3-L3 segment of the spinal cord. Thoracolumbar radiography revealed an abnormal radiopacity suggestive of a mass at T11...
April 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28299456/interlocking-horizontal-mattress-suture-versus-kakiuchi-technique-in-repair-of-achilles-tendon-rupture-a-biomechanical-study
#5
Matteo Guzzini, Riccardo Maria Lanzetti, Lorenzo Proietti, Daniele Mazza, Mattia Fabbri, Edoardo Monaco, Germano Ferri, Andrea Ferretti
BACKGROUND: In recent years, the type of surgical treatment for Achilles tendon rupture has been the subject of controversial debate. This biomechanical study evaluates for the first time in literature the ultimate failure load (UFL) of interlocking horizontal mattress (IHM) suture as compared with Kakiuchi suture in Achilles tendon rupture. The hypothesis is that IHM suture can be performed also for Achilles tendon rupture and ensures higher resistance compared with the traditional Kakiuchi suture...
March 15, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28292620/in%C3%A2-vitro-effects-of-phthalate-esters-in-human-myometrial-and-leiomyoma-cells-and-increased-urinary-level-of-phthalate-metabolite-in-women-with-uterine-leiomyoma
#6
Jin Hee Kim, Sung Hoon Kim, Young Sang Oh, Hyo Jin Ihm, Hee Dong Chae, Chung-Hoon Kim, Byung Moon Kang
OBJECTIVE: To investigate the possible role of phthalate, a ubiquitous chemical used in consumer products, in the pathogenesis of uterine leiomyoma. DESIGN: Experimental and prospective case-control study using human samples. SETTING: University hospital. PATIENT(S): Fifty-three women with histologic evidence of uterine leiomyoma and 33 surgical controls without leiomyoma. INTERVENTION(S): Human myometrial and leiomyoma cells were treated with di-(2-thylhexyl)-phthalate (DEHP)...
March 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28275385/severe-hypernatremia-caused-by-acute-exogenous-salt-intake-combined-with-primary-hypothyroidism
#7
Woo Jin Jung, Su Min Park, Jong Man Park, Harin Rhee, Il Young Kim, Dong Won Lee, Soo Bong Lee, Eun Young Seong, Ihm Soo Kwak, Sang Heon Song
This report describes a case of severe hypernatremia with a serum sodium concentration of 188.1mmol/L caused by exogenous salt intake. A 26-year-old man diagnosed with Crohn's disease 5 years previously visited our clinic due to generalized edema and personality changes, with aggressive behavior. He had compulsively consumed salts, ingesting approximately 154 g of salt over the last 4 days. Despite careful fluid management that included not only hypotonic fluid therapy for 8 hours but also hypertonic saline administration, his serum sodium level decreased sharply at 40...
December 2016: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/28275384/genetic-variations-of-tyrosine-hydroxylase-in-the-pathogenesis-of-hypertension
#8
REVIEW
Yu Ho Lee, Yang Gyun Kim, Ju-Young Moon, Jin Sug Kim, Kyung-Hwan Jeong, Tae Won Lee, Chun-Gyoo Ihm, Sang Ho Lee
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension...
December 2016: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/28252036/universality-of-periodicity-as-revealed-from-interlayer-mediated-cracks
#9
Myung Rae Cho, Jong Hyun Jung, Min Key Seo, Sung Un Cho, Young Duck Kim, Jae Hyun Lee, Yong Seung Kim, Pilkwang Kim, James Hone, Jisoon Ihm, Yun Daniel Park
A crack and its propagation is a challenging multiscale materials phenomenon of broad interest, from nanoscience to exogeology. Particularly in fracture mechanics, periodicities are of high scientific interest. However, a full understanding of this phenomenon across various physical scales is lacking. Here, we demonstrate periodic interlayer-mediated thin film crack propagation and discuss the governing conditions resulting in their periodicity as being universal. We show strong confinement of thin film cracks and arbitrary steering of their propagation by inserting a predefined thin interlayer, composed of either a polymer, metal, or even atomically thin graphene, between the substrate and the brittle thin film...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218042/doxorubicin-has-a-synergistic-cytotoxicity-with-cucurbitacin-b-in-anaplastic-thyroid-carcinoma-cells
#10
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee
In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used. Cell viability, the percentage of viable cells, and cytotoxic activity were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, multiplexed cytotoxicity assay, and cytotoxicity assay, respectively. Reactive oxygen species production was measured. In experiments, doxorubicin and cucurbitacin B reduced cell viability in a dose- and time-dependent manner...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28206762/influence-of-lafeo3-surface-termination-on-water-reactivity
#11
Kelsey A Stoerzinger, Ryan Comes, Steven R Spurgeon, Suntharampillai Thevuthasan, Kyuwook Ihm, Ethan J Crumlin, Scott A Chambers
The polarity of oxide surfaces can dramatically impact their surface reactivity, in particular, with polar molecules such as water. The surface species that result from this interaction change the oxide electronic structure and chemical reactivity in applications such as photoelectrochemistry but are challenging to probe experimentally. Here, we report a detailed study of the surface chemistry and electronic structure of the perovskite LaFeO3 in humid conditions using ambient-pressure X-ray photoelectron spectroscopy...
February 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28196107/fluid-overload-and-survival-in-critically-ill-patients-with-acute-kidney-injury-receiving-continuous-renal-replacement-therapy
#12
Il Young Kim, Joo Hui Kim, Dong Won Lee, Soo Bong Lee, Harin Rhee, Eun Young Seong, Ihm Soo Kwak, Sang Heon Song
BACKGROUND: Fluid overload is known to be associated with increased mortality in patients with acute kidney injury (AKI) who are critically ill. In this study, we intended to uncover whether the adverse effect of fluid overload on survival could be applied to all of the patients with AKI who received continuous renal replacement therapy (CRRT). METHODS: We analyzed 341 patients with AKI who received CRRT in our intensive care units. The presence of fluid overload was defined as a minimum 10% increase in body weight from the baseline...
2017: PloS One
https://www.readbyqxmd.com/read/28193850/retrospective-observational-study-of-trends-in-hospital-admissions-for-idiopathic-pulmonary-fibrosis-in-spain-2004-2013-using-administrative-data
#13
Fernando Pedraza-Serrano, Ana López de Andrés, Rodrigo Jiménez-García, Isabel Jiménez-Trujillo, Valentín Hernández-Barrera, Gema Sánchez-Muñoz, Luis Puente-Maestu, Javier de Miguel-Díez
OBJECTIVE: To assess changes in incidence, diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), economic costs and in-hospital mortality (IHM) associated with idiopathic pulmonary fibrosis (IPF). METHODS: We identified patients hospitalised with IPF in Spain from 2004 to 2013. Data were collected from the National Hospital Discharge Database. RESULTS: The study population comprised 22 214 patients. Overall crude incidence increased from 3...
February 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28190617/chronic-obstructive-pulmonary-disease-predicts-higher-incidence-and-in-hospital-mortality-for-atrial-fibrillation-an-observational-study-using-hospital-discharge-data-in-spain-2004-2013
#14
Manuel Méndez-Bailón, Ana Lopez-de-Andrés, Javier de Miguel-Diez, José Mª de Miguel-Yanes, Valentín Hernández-Barrera, Nuria Muñoz-Rivas, Noel Lorenzo-Villalba, Rodrigo Jiménez-García
BACKGROUND: Our objectives were to describe and compare trends in the incidence of hospitalization for atrial fibrillation (AF) in patients with and without chronic obstructive pulmonary disease (COPD) in Spain during 2004-2013 and to assess the effect of COPD on the in-hospital mortality (IHM) of patients with AF. METHODS: We performed a retrospective study using the Spanish National Hospital Discharge Database. The study population comprised patients≥40years with a primary diagnosis of AF...
February 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28187963/a-modified-elixhauser-score-for-predicting-in-hospital-mortality-in-internal-medicine-admissions
#15
Fabio Fabbian, Alfredo De Giorgi, Elisa Maietti, Massimo Gallerani, Marco Pala, Rosaria Cappadona, Roberto Manfredini, Ugo Fedeli
BACKGROUND: In-hospital mortality (IHM) is an indicator of the quality of care provided. The two most widely used scores for predicting IHM by International Classification of Diseases (ICD) codes are the Elixhauser (EI) and the Charlson Comorbidity indexes. Our aim was to obtain new measures based on internal medicine ICD codes for the original EI, to detect risk for IHM. MATERIAL AND METHODS: This single-center retrospective study included hospital admissions for any cause in the department of internal medicine between January 1, 2000, and December 31, 2013, recorded in the hospital database...
February 8, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28187703/ihms-a-database-integrating-human-histone-modification-data-across-developmental-stages-and-tissues
#16
Yanglan Gan, Han Tao, Jihong Guan, Shuigeng Zhou
BACKGROUND: Differences in chromatin states are critical to the multiplicity of cell states. Recently genome-wide histone modification maps of diverse human developmental stages and tissues have been charted. DESCRIPTION: To facilitate the investigation of epigenetic dynamics and regulatory mechanisms in cellular differentiation processes, we developed iHMS, an integrated human histone modification database that incorporates massive histone modification maps spanning different developmental stages, lineages and tissues ( http://www...
February 11, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28178341/enhanced-expression-of-two-discrete-isoforms-of-matrix-metalloproteinase-2-in-experimental-and-human-diabetic-nephropathy
#17
Sang Soo Kim, Nari Shin, Sun Sik Bae, Min Young Lee, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, David H Lovett, Sang Heon Song
BACKGROUND: We recently reported on the enhanced expression of two isoforms of matrix metalloproteinase-2 (MMP-2) in human renal transplantation delayed graft function. These consist of the conventional secreted, full length MMP-2 isoform (FL-MMP-2) and a novel intracellular N-Terminal Truncated isoform (NTT-MMP-2) generated by oxidative stress-mediated activation of an alternate promoter in the MMP-2 first intron. Here we evaluated the effect of hyperglycemia and diabetes mellitus on the in vitro and in vivo expression of the two MMP-2 isoforms...
2017: PloS One
https://www.readbyqxmd.com/read/28139447/incidence-characteristic-and-outcomes-of-ventilator-associated-pneumonia-among-type-2-diabetes-patients-an-observational-population-based-study-in-spain
#18
Isabel Jiménez-Trujillo, Rodrigo Jiménez-García, Javier de Miguel-Díez, José M de Miguel-Yanes, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Napoleón Pérez-Farinós, Miguel-Ángel Salinero-Fort, Ana López-de-Andrés
BACKGROUND: To describe incidence, characteristics and outcomes of ventilator-associated pneumonia (VAP) during hospitalization among patients with or without type 2 diabetes (T2DM). METHODS: We used the Spanish national hospital discharge database to select all hospitalization with VAP in subjects aged 40years or more from 2010 to 2014. We analyzed incidence, patient comorbidities, procedures, pneumonia pathogens and in-hospital outcomes according to diabetes status (T2DM and no-diabetes)...
January 27, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28128598/results-from-a-search-for-dark-matter-in-the-complete-lux-exposure
#19
D S Akerib, S Alsum, H M Araújo, X Bai, A J Bailey, J Balajthy, P Beltrame, E P Bernard, A Bernstein, T P Biesiadzinski, E M Boulton, R Bramante, P Brás, D Byram, S B Cahn, M C Carmona-Benitez, C Chan, A A Chiller, C Chiller, A Currie, J E Cutter, T J R Davison, A Dobi, J E Y Dobson, E Druszkiewicz, B N Edwards, C H Faham, S Fiorucci, R J Gaitskell, V M Gehman, C Ghag, K R Gibson, M G D Gilchriese, C R Hall, M Hanhardt, S J Haselschwardt, S A Hertel, D P Hogan, M Horn, D Q Huang, C M Ignarra, M Ihm, R G Jacobsen, W Ji, K Kamdin, K Kazkaz, D Khaitan, R Knoche, N A Larsen, C Lee, B G Lenardo, K T Lesko, A Lindote, M I Lopes, A Manalaysay, R L Mannino, M F Marzioni, D N McKinsey, D-M Mei, J Mock, M Moongweluwan, J A Morad, A St J Murphy, C Nehrkorn, H N Nelson, F Neves, K O'Sullivan, K C Oliver-Mallory, K J Palladino, E K Pease, P Phelps, L Reichhart, C Rhyne, S Shaw, T A Shutt, C Silva, M Solmaz, V N Solovov, P Sorensen, S Stephenson, T J Sumner, M Szydagis, D J Taylor, W C Taylor, B P Tennyson, P A Terman, D R Tiedt, W H To, M Tripathi, L Tvrznikova, S Uvarov, J R Verbus, R C Webb, J T White, T J Whitis, M S Witherell, F L H Wolfs, J Xu, K Yazdani, S K Young, C Zhang
We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4}  kg day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils...
January 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28120562/serum-chemerin-levels-are-associated-with-visceral-adiposity-independent-of-waist-circumference-in-newly-diagnosed-type-2-diabetic-subjects
#20
Dae Young Cheon, Jun Goo Kang, Seong Jin Lee, Sung Hee Ihm, Eun Jig Lee, Moon Gi Choi, Hyung Joon Yoo, Chul Sik Kim
PURPOSE: Chemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationship between visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity. MATERIALS AND METHODS: This study included 102 subjects newly diagnosed with T2DM. The relationships between serum chemerin levels and clinical and biochemical parameters were examined...
March 2017: Yonsei Medical Journal
keyword
keyword
56826
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"