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https://www.readbyqxmd.com/read/29779118/change-in-kidney-function-after-unilateral-adrenalectomy-in-patients-with-primary-aldosteronism-identification-of-risk-factors-for-decreased-kidney-function
#1
Il Young Kim, In Seong Park, Min Jeong Kim, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Sang Heon Song, Hyun Chul Chung
PURPOSE: Glomerular filtration rate (GFR) has been reported to decrease after unilateral adrenalectomy in patients with primary aldosteronism (PA). The aim of this study was to identify clinical predictors for decreased GFR after adrenalectomy in patients with PA. METHODS: The records of 187 patients (98 patients with PA and 89 with non-PA adrenal disease) who were followed up for at least 6 months after unilateral adrenalectomy were retrospectively analyzed. Estimated GFR (eGFR) was investigated at 1, 3, and 6 months postoperatively...
May 19, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29762828/neoplasms-and-renal-transplantation-impact-of-gender-comorbidity-and-age-on-in-hospital-mortality-a-retrospective-study-in-the-region-emilia-romagna-of-italy
#2
F Fabbian, A De Giorgi, R Tiseo, R Cappadona, B Zucchi, M Rubbini, F Signani, A Storari, R De Giorgio, G La Manna, R Manfredini
OBJECTIVE: The aim of this retrospective study was to investigate the relationship between cancer, non-immunologic comorbidity, estimated by International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codification, gender and in-hospital mortality (IHM) in a large sample of renal transplant recipients (RTRs) living in the region Emilia-Romagna (RER) of Italy. PATIENTS AND METHODS: We evaluated IHM in RTRs admitted between 2000 and 2013 recorded in the RER database...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29756414/arterial-to-end-tidal-carbon-dioxide-tension-difference-co-2-gap-as-a-prognostic-marker-for-adverse-outcomes-in-emergency-department-patients-presenting-with-suspected-sepsis
#3
Amith Shetty, Sebastian Sparenberg, Kristian Adams, Selwyn Selvedran, Benjamin Tang, Kim Hanna, Jonathan Iredell
OBJECTIVE: The arterial to end-tidal carbon dioxide tension difference (CO2 gap) correlates with physiologic dead space. The prognostic value of increased CO2 gap in trauma and respiratory distress patients is documented. Transpulmonary arteriovenous shunting is identified as a predictor of mortality in non-pulmonary sepsis. We set out to investigate the prognostic value of the CO2 gap in a pilot study of patients with suspected sepsis from non-respiratory causes. METHODS: Patients presenting to tertiary Australian ED with suspected sepsis (n = 215) underwent near-simultaneous end-tidal carbon dioxide and partial pressure of carbon dioxide measurements...
May 13, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29753789/diverse-cavity-types-and-evidence-that-mechanical-action-on-the-necrotic-granuloma-drives-tuberculous-cavitation
#4
Elizabeth A Ihms, Michael E Urbanowski, William R Bishai
Effacement of normal lung parenchyma by cavities is an important sequela of pulmonary tuberculosis. Despite its clinical significance, the pathogenesis of tuberculous cavitation is poorly understood, with controversy as to whether the fundamental mechanism involves matrix depletion, lipid pneumonia, or mechanical factors. In this study, a repetitive aerosol infection model using Mycobacterium tuberculosis was used to generate cavities in 20 New Zealand White rabbits. Serial computed tomography was performed to monitor cavity progression over 14 weeks...
May 10, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29729509/brominated-flame-retardants-recommendation-for-different-listing-under-the-hong-kong-convention
#5
Jelena Čulin
When the Hong Kong International Convention for the Safe and Environmentally Sound Recycling of Ships, 2009 enters into effect, ships to be sent for recycling will be required to carry an Inventory of Hazardous Materials (IHM) on board, which identifies the hazardous materials contained in the ship's structure or equipment. In its current form, IHM covers two classes of brominated flame retardants (BFRs), namely polybrominated biphenyls and polybrominated diphenyl ethers. Emerging evidence from recent literature suggests that members of all classes of BFRs are present in all environmental compartments and that exposure to them is associated with a wide range of harmful effects in humans and animals, effects that include endocrine disruption...
May 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29724386/comorbidities-and-risk-of-mortality-among-hospitalized-patients-with-idiopathic-pulmonary-fibrosis-in-spain-from-2002-to-2014
#6
Fernando Pedraza-Serrano, Rodrigo Jiménez-García, Ana López-de-Andrés, Valentín Hernández-Barrera, Jesús Esteban-Hernández, Gema Sánchez-Muñoz, Luis Puente-Maestu, Javier de-Miguel-Díez
BACKGROUND: To describe and compare the comorbid conditions, the in-hospital mortality (IHM) and the length of hospital stay (LOHS) among idiopathic pulmonary fibrosis (IPF) patients and non-IPF-matched patients hospitalized in Spain. We assess the performance of the Charlson Comorbidity Index[CCI] and the Elixhauser Comorbidity Index[ECI] to predict IHM in IPF and we identify the specific predictive factors of IHM in patients suffering IPF. METHODS: We identified patients with IPF hospitalized in years 2002, 2006, 2010 and 2014...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29724290/determination-of-the-contamination-by-azole-antimycotics-in-hospital-and-house-sewage-a-pilot-project-for-the-city-of-dresden
#7
H Knoth, S Ihme, R Oertel, A Matthes, C Ritter
Medicininal compounds and their metabolites are known to end up in sewerage and may slip through the cleaning process. Azole antimycotics are frequently used in hospitals, in particular for patients with cancer or immunosuppression. The aim of the study was to determine whether measurable azole antimycotic concentrations were introducted in the sewarage drain of an acute care hospital with special interest in oncology and hematology and the extent of removal of antimycotics by the sewerage treatment plant. For this, the concentrations of three commonly used azole antimycotics were measured in the effluent of the sewerage drain at the University Hospital Dresden, as well as in the influent and effluent of the main sewerage treatment plant of the city...
May 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29713256/primary-glomerulonephritis-with-unique-c4d-deposition-and-concurrent-non-infectious-intermediate-uveitis-a-case-report-and-literature-review
#8
Jong Man Park, Harin Lee, Sangheon Song, Eun Young Seong, Ihm Soo Kwak, Sung Who Park, Young-Keum Kim, Nari Shin, Mee Young Sol
C4 glomerulopathy is a recently introduced entity that presents with bright C4d staining and minimal or absent immunoglobulin and C3 staining. We report a case of a 62-year-old man with C4 glomerulonephritis (GN) and uveitis. He presented to the nephrology department with proteinuria and hematuria. The patient also had intermediate uveitis along with proteinuria and hematuria. A kidney biopsy that was performed in light of continuing proteinuria and hematuria showed a focal proliferative, focal sclerotic glomerulopathy pattern on light microscopy, absent staining for immunoglobulin or C3 by immunofluorescence microscopy, with bright staining for C4d on immunohistochemistry, and electron-dense deposits on electron microscopy...
April 30, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29697771/burden-of-disease-studies-in-the-who-european-region-a-mapping-exercise
#9
Mark R O'Donovan, Christian Gapp, Claudia Stein
Background: The World Health Organization (WHO) and the Institute for Health Metrics and Evaluation (IHME) have produced numerous global burden of disease (GBD) estimates since the 1990s, using disability-adjusted life-years (DALYs). Here we attempt to identify studies that have either independent DALY estimates or build on the work of WHO and IHME, for the WHO European Region, categorize them by scope of disease analysis and geographic coverage, and briefly compare their methodology (age weighting, discounting and disability weights)...
April 25, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29690479/the-spurious-dragonfly-the-intricate-nomenclatural-problems-regarding-the-names-libelloides-and-libelluloides-neuroptera-ascalaphidae-et-myrmeleontidae
#10
Roberto A Pantaleoni, Laura Loru
Around 1970 Tjeder suggested two changes to the nomenclature of the Ascalaphidae regarding the names Libelloides and libelluloides. To avoid future confusion, we augment Tjeder's work by analyzing the nomenclatural status of all taxa related to these names-specifically Libelloides Schäffer, 1763 and Libelloides coccajus ([Denis et Schiffermüller], 1775), Ascalaphidae, and Palpares libelluloides (Linnaeus, 1764), Myrmeleontidae. After a short historical preamble, we treat the three taxa in chronological order of description...
February 27, 2018: Zootaxa
https://www.readbyqxmd.com/read/29673890/efficacy-and-safety-of-fixed-dose-combination-therapy-with-telmisartan-and-rosuvastatin-in-korean-patients-with-hypertension-and-dyslipidemia-telsta-yu-telmisartan-rosuvastatin-from-yuhan-a-multicenter-randomized-4-arm-double-blind-placebo-controlled-phase
#11
Gyu Chul Oh, Jung-Kyu Han, Ki Hoon Han, Min-Su Hyon, Joon Hyung Doh, Moo Hyun Kim, Jin-Ok Jeong, Jang-Ho Bae, Sang Hyun Kim, Byung-Su Yoo, Sang Hong Baek, Moo-Yong Rhee, Sang-Hyun Ihm, Jung Hoon Sung, Young Jin Choi, Soo-Joong Kim, Kyung-Soon Hong, Byoung Kwon Lee, JangHyun Cho, Eun Seok Shin, Jay Young Rhew, Hyunsu Kim, Hyo-Soo Kim
PURPOSE: Hypertension and dyslipidemia are 2 risk factors of cardiovascular disease that often present simultaneously. Traditionally, treatment of these multiple conditions required separate medications for each disease, which may result in poor compliance and thus lead to possible treatment failure. Fixed-dose combination (FDC) therapy with a single pill may be a solution in these situations. METHODS: This multicenter, 8-week, randomized, double-blind, Phase III study evaluated the efficacy and safety of FDC treatment with telmisartan (80 mg) and rosuvastatin calcium (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia...
April 16, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29673852/national-trends-and-outcomes-of-hospitalizations-for-pulmonary-hypertension-in-spain-2001-2014
#12
Javier de-Miguel-Díez, Ana López-de-Andrés, Valentin Hernandez-Barrera, Isabel Jimenez-Trujillo, Jose María de-Miguel-Yanes, Manuel Mendez-Bailón, Rodrigo Jimenez-Garcia
OBJECTIVE: To assess changes in incidence, diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) for patients hospitalized with pulmonary hypertension (PH). METHODS: We included patients hospitalized with PH in Spain from 2001 to 2014. The data were collected from the National Hospital Discharge Database. RESULTS: We included 644,436 discharges (43.31% males and 56.09% females) admitted for primary PH (8...
April 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29667831/a-rigorous-method-of-calculating-exfoliation-energies-from-first-principles
#13
Jong Hyun Jung, Cheol-Hwan Park, Jisoon Ihm
The exfoliation energy, the energy required to peel off an atomic layer from the surface of a bulk material, is of fundamental importance in the science and engineering of two-dimensional materials. Traditionally, the exfoliation energy of a material has been obtained from first-principles by calculating the difference in the ground-state energy between (i) a slab of N atomic layers ( N ≫ 1) and (ii) a slab of N - 1 atomic layers plus an atomic layer separated from the slab. In this paper, we prove that the exfoliation energy can be obtained exactly as the difference in the ground-state energy between a bulk material (per atomic layer) and a single isolated layer...
April 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29616294/online-low-field-nmr-spectroscopy-for-process-control-of-an-industrial-lithiation-reaction-automated-data-analysis
#14
Simon Kern, Klas Meyer, Svetlana Guhl, Patrick Gräßer, Andrea Paul, Rudibert King, Michael Maiwald
Monitoring specific chemical properties is the key to chemical process control. Today, mainly optical online methods are applied, which require time- and cost-intensive calibration effort. NMR spectroscopy, with its advantage being a direct comparison method without need for calibration, has a high potential for enabling closed-loop process control while exhibiting short set-up times. Compact NMR instruments make NMR spectroscopy accessible in industrial and rough environments for process monitoring and advanced process control strategies...
April 4, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29611381/determining-genotypic-drug-resistance-by-ion-semiconductor-sequencing-with-the-ion-ampliseq%C3%A2-tb-panel-in-multidrug-resistant-mycobacterium-tuberculosis-isolates
#15
Joonhong Park, So Youn Shin, Kyungjong Kim, Kuhn Park, Soyoung Shin, Chunhwa Ihm
BACKGROUND: We examined the feasibility of a full-length gene analysis for the drug resistance-related genes inhA, katG, rpoB, pncA, rpsL, embB, eis, and gyrA using ion semiconductor next-generation sequencing (NGS) and compared the results with those obtained from conventional phenotypic drug susceptibility testing (DST) in multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates. METHODS: We extracted genomic DNA from 30 pure MDR-TB isolates with antibiotic susceptibility profiles confirmed by phenotypic DST for isoniazid (INH), rifampin (RIF), ethambutol (EMB), pyrazinamide (PZA), amikacin (AMK), kanamycin (KM), streptomycin (SM), and fluoroquinolones (FQs) including ofloxacin, moxifloxacin, and levofloxacin...
July 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29608214/heart-rate-and-bone-mineral-density-in-older-women-with-hypertension-results-from-the-korea-national-health-and-nutritional-examination-survey
#16
Mi-Hyang Jung, Ho-Joong Youn, Sang-Hyun Ihm, Hae Ok Jung, Kyung-Soon Hong
OBJECTIVES: To determine whether high heart rate is associated with low bone mineral density (BMD) in older women with hypertension. DESIGN: Retrospective cohort study. SETTING: Population-based study conducted in Korea (Korea National Health and Nutritional Examination Survey 2009-10). PARTICIPANTS: Postmenopausal women aged 60 and older with hypertension (N=981) divided into 2 groups according to resting heart rate, with a cut-off value of 80 bpm, which has been found to be associated with osteoporosis...
April 2, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29590747/collagenous-spherulosis-associated-with-lobular-carcinoma-in-situ-of-the-breast-two-case-reports
#17
Ga-Eon Kim, Nah Ihm Kim, Ji Shin Lee, Min Ho Park
Collagenous spherulosis (CS) of the breast is a distinctive disease, and is characterized by myoepithelial and epithelial proliferation of nodules in the eosinophilic or basophilic basement membrane enclosed in spherical spaces. CS is rare, but frequently occurs in association with other benign proliferative lesions of the breast. CS is also associated with lobular carcinoma in situ (LCIS). Here, we report two cases of CS associated with LCIS of the breast. Two patients presented with nodules on ultrasound imaging...
March 29, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29559743/stress-induced-phosphoprotein-1-mediates-hepatocellular-carcinoma-metastasis-after-insufficient-radiofrequency-ablation
#18
Tianhong Su, Junbin Liao, Zihao Dai, Lixia Xu, Shuling Chen, Yifei Wang, Zhenwei Peng, Qiuyang Zhang, Sui Peng, Ming Kuang
Recent studies indicated that insufficient radiofrequency ablation (RFA) could endow hepatocellular carcinoma (HCC) with higher aggressive potential. Stress-induced phosphoprotein 1 (STIP1), which was found highly expressed in HCC, is a chaperone molecule mediating cell homeostasis under thermal stress. We aimed to explore the role of STIP1 on the metastasis of residual HCC after RFA. Mice model with orthotopic HCC implants or caudal vein injection were employed to assess potential of lung metastasis and/or intrahepatic metastasis (IHM) of HCC cells...
March 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29554286/repetitive-aerosol-exposure-promotes-cavitary-tuberculosis-and-enables-screening-for-targeted-inhibitors-of-extensive-lung-destruction
#19
Michael E Urbanowski, Elizabeth A Ihms, Kristina Bigelow, André Kübler, Paul T Elkington, William R Bishai
Background: Cavitation is a serious consequence of tuberculosis. We tested the hypothesis that repetitive exposure to the same total bacterial burden of Mtb drives greater lung destruction than a single exposure. We also tested whether inhibition of endogenous MMP1 may inhibit cavitation during TB. Methods: Over a three weeks interval we infected rabbits with either 5 aerosols of 500 CFU of Mtb or a single aerosol of 2500 CFU plus four sham aerosols. We administered the MMP1 inhibitor cipemastat (100 mg/kg daily) from week 5-10 to a subset of the animals...
March 15, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29507277/light-chain-deposition-disease-associated-with-multiple-myeloma-developing-in-late-pregnancy
#20
Min Jeong Kim, Joo Hui Kim, Il Young Kim, Soo Bong Lee, In Seong Park, Mi Yeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Ihm Soo Kwak, Dong Won Lee
Preeclampsia is the most common cause of proteinuria with hypertension during pregnancy. Primary kidney disease and kidney disease secondary to systemic disorders may rarely occur during pregnancy, resulting in proteinuria. A 34-year-old woman was admitted to our hospital with abdominal distention and lower extremity edema. The pregnancy was terminated at the 24th week of gestation due to preterm labor. Even after the delivery, proteinuria and renal deterioration continued to progress. The M-peak was not found on serum and urine protein electrophoresis...
March 2018: Iranian Journal of Kidney Diseases
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