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https://www.readbyqxmd.com/read/29151154/visit-to-visit-variability-of-systolic-blood-pressure-predicts-all-cause-mortality-in-patients-received-percutaneous-coronary-intervention-with-drug-eluting-stents
#1
Suk Min Seo, Woo-Baek Chung, Ik Jun Choi, Yoon-Seok Koh, Sang-Hyun Ihm, Pum-Jun Kim, Wook Sung Chung, Ki-Bae Seung
Blood pressure (BP) and its variability are associated with atherosclerotic disease and cardiovascular events. The prognostic implications of outpatient clinic visit-to-visit blood pressure variability (BPV) are unknown in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). A total of 1,463 patients undergoing PCI with DES were consecutively enrolled from January 2009 to December 2013. We analyzed the 1,234 patients, who measured clinic BP more than three times during the first year after PCI...
November 18, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29147952/gemigliptin-a-novel-dipeptidyl-peptidase-iv-inhibitor-exerts-a-synergistic-cytotoxicity-with-the-histone-deacetylase-inhibitor-pxd101-in-thyroid-carcinoma-cells
#2
S H Kim, J G Kang, C S Kim, S-H Ihm, M G Choi, H J Yoo, S J Lee
PURPOSE: The influence of the dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with the histone deacetylase inhibitor PXD101 on survival of thyroid carcinoma cells was investigated. METHODS: SW1736, TPC-1, 8505C and BCPAP human thyroid carcinoma cells were used. To assess cell survival, cell viability, the percentage of viable cells and dead cells, cytotoxic activity, ATP levels and FACS analysis were measured. To validate the impact of gemigliptin combined with PXD101, the interactions were estimated by obtaining combination index in cells treated with two agents...
November 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29132321/the-role-of-the-specialized-team-in-the-operation-of-continuous-renal-replacement-therapy-a-single-center-experience
#3
Harin Rhee, Gum Sook Jang, Miyeun Han, In Seong Park, Il Young Kim, Sang Heon Song, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak
BACKGROUND: The requirement of continuous renal replacement therapy (CRRT) is increasing with the growing incidence of acute kidney injury (AKI). The decision to initiate CRRT is not difficult if an adequate medical history is obtained. However, the handling and maintenance of CRRT constitute a labor-intensive intervention that requires specialized skills. For these reasons, our center organized a specialized CRRT team in March 2013. The aim of this study is to report on the role of a specialized CRRT team and to evaluate the team's outcome...
November 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29121921/transcatheter-aortic-valve-implantation-and-surgical-aortic-valve-replacement-among-hospitalized-patients-with-and-without-type-2-diabetes-mellitus-in-spain-2014-2015
#4
Manuel Mendez-Bailon, Noel Lorenzo-Villalba, Nuria Muñoz-Rivas, Jose Maria de Miguel-Yanes, Javier De Miguel-Diez, Josep Comín-Colet, Valentin Hernandez-Barrera, Rodrigo Jimenez-Garcia, Ana Lopez-de-Andres
BACKGROUND: Type 2 diabetes mellitus (T2DM) is strongly related to the in-hospital and short-term prognosis in patients with cardiovascular diseases needing surgical or invasive interventions. How T2DM might influence the treatment of aortic stenosis (AS) has not been completely elucidated for surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI). The aims of this study were: (1) to describe the use of aortic valve replacement procedures (TAVI and SAVR) among hospitalized patients with and without T2DM; and (2) to identify factors associated with in hospital mortality (IHM) among patients undergoing these procedures...
November 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29097809/the-burden-and-challenges-of-tuberculosis-in-china-findings-from-the-global-burden-of-disease-study-2015
#5
Sui Zhu, Lan Xia, Shicheng Yu, Saobing Chen, Juying Zhang
To achieve the End Tuberculosis (TB) Strategy, it is important to understand the characteristics of TB in China, which may provide the government with important clues for controlling TB by 2030. Data from the Global Burden of Disease Study 2015 (GBD 2015) and Institute for Health Metrics and Evaluation (IHME) were reviewed and analysed. The age-standardized death rate decreased by 83.79% [95% uncertainty interval (UI) 73.06-87.10] from 1990 to 2015. The age-standardized prevalence of TB in males decreased steadily by 33...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29075291/baseline-renal-function-predicts-hyponatremia-in-liver-cirrhosis-patients-treated-with-terlipressin-for-variceal-bleeding
#6
Sung Eun Kim, Dong Min Jung, Ji Won Park, Yeonmi Ju, Bohyun Lee, Hyoung Su Kim, Ki Tae Suk, Myoung Kuk Jang, Sang Hoon Park, Jun Goo Kang, Jae Seung Soh, Hyun Lim, Ho Suk Kang, Sung Hoon Moon, ChulSik Kim, SeongJin Lee, Jong Hyeok Kim, Myung Seok Lee, Dong Joon Kim, Sung-Hee Ihm, ChoongKee Park
OBJECTIVES: Terlipressin is safely used for acute variceal bleeding. However, side effects, such as hyponatremia, although very rare, can occur. We investigated the development of hyponatremia in cirrhotic patients who had acute variceal bleeding treated with terlipressin and the identification of the risk factors associated with the development of hyponatremia. DESIGN AND METHODS: This retrospective, case-control study investigated 88 cirrhotic patients who developed hyponatremia and 176 controls that did not develop hyponatremia and were matched in terms of age and gender during the same period following terlipressin administration...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29071590/racial-ethnic-disparities-in-morbidity-and-mortality-for-preterm-neonates-admitted-to-a-tertiary-neonatal-intensive-care-unit
#7
Courtney Townsel, Rebecca Keller, Chia-Ling Kuo, Winston A Campbell, Naveed Hussain
OBJECTIVE: The objective of this study was to assess whether in-hospital morbidity or mortality differed by race/ethnicity for preterm neonates admitted to the neonatal intensive care unit (NICU). STUDY DESIGN: In a retrospective cohort study, preterm infants, < 37 weeks, were admitted to the NICU from 1994 to 2009. Exclusions included structural anomalies and aneuploidy. Primary outcome was in-hospital mortality (IHM). Secondary outcomes were respiratory distress syndrome (RDS), interventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), and retinopathy of prematurity (ROP)...
October 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29067383/integrated-microhall-magnetometer-to-measure-the-magnetic-properties-of-nanoparticles
#8
Changwook Min, Jongmin Park, Jae Kyoung Mun, Yongjun Lim, Jouha Min, Jong-Won Lim, Dong-Min Kang, Ho-Kyun Ahn, Tae-Hyun Shin, Jinwoo Cheon, Hae-Seung Lee, Ralph Weissleder, Cesar M Castro, Hakho Lee
Magnetic nanoparticles (MNPs) are widely used in biomedical and clinical applications, including medical imaging, therapeutics, and biological sample processing. Rapid characterization of MNPs, notably their magnetic moments, should facilitate optimization of particle synthesis and accelerate assay development. Here, we report a compact and low-cost magnetometer for fast, on-site MNP characterization. Termed integrated microHall magnetometer (iHM), our device was fabricated using standard semiconductor processes: an array of Hall sensors, transistor switches, and amplifiers were integrated into a single chip, thus improving the detection sensitivity and facilitating chip operation...
October 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29061335/research-investments-for-uk-infectious-disease-research-1997-2013-a-systematic-analysis-of-awards-to-uk-institutions-alongside-national-burden-of-disease
#9
Michael G Head, Rebecca J Brown, Stuart C Clarke
INTRODUCTION: Infectious disease remains a significant burden in the UK and the focus of significant amounts of research investment each year. The Research Investments in Global Health study has systematically assessed levels of funding for infection research, and here considers investment alongside UK burden of individual infectious diseases. METHODS: The study included awards to UK institutions between 1997 and 2013 that were related to infectious disease. Awards related to global health projects were excluded here...
October 20, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29042903/renal-tubular-acidosis-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#10
Su Woong Jung, Eun Ji Park, Jin Sug Kim, Tae Won Lee, Chun Gyoo Ihm, Sang Ho Lee, Ju-Young Moon, Yang Gyun Kim, Kyung Hwan Jeong
Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the exocrine glands resulting in decreased saliva and tear production. It uncommonly involves the kidneys in various forms, including tubulointerstitial nephritis, renal tubular acidosis, Fanconi syndrome, and rarely glomerulonephritis. Its clinical symptoms include muscle weakness, periodic paralysis, and bone pain due to metabolic acidosis and electrolyte imbalance. Herein, we describe the cases of two women with pSS whose presenting symptoms involve the kidneys...
September 2017: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/29035902/comparison-of-direct-patient-care-costs-and-quality-outcomes-of-the-teaching-and-non-teaching-hospitalist-services-at-a-large-academic-medical-center
#11
Jose A Perez, Melina Awar, Aryan Nezamabadi, Richard Ogunti, Mamta Puppala, Lara Colton, Johanna M Clewing, Sayali Ketkar, Stephen T C Wong, Richard J Robbins
PURPOSE: To compare costs of care and quality outcomes between teaching and non-teaching hospitalist services, while testing the assumption resident-driven care is more expensive. METHOD: Records of inpatients with the top 20 Medicare Severity Diagnosis-Related Groups (MS-DRGs) admitted to the University Teaching Service (UTS) and non-teaching hospitalist service (NTHS) at Houston Methodist Hospital from 2014-2015 were analyzed retrospectively. Direct costs of care, length of stay (LOS), in-hospital mortality (IHM), 30-day readmission rate (30DRR), and consultant utilization were compared between the UTS and NTHS...
October 13, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29020764/incidence-and-risk-factors-for-tenofovir-associated-nephrotoxicity-among-human-immunodeficiency-virus-infected-patients-in-korea
#12
Jeong Eun Lee, Shinwon Lee, Sang Heon Song, Ihm Soo Kwak, Sun Hee Lee
Background/Aims: Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients in Korea. Methods: A single-center retrospective cohort study was conducted on HIVinfected patients in Korea. We included patients who had started TDF or abacavir (ABC)-based antiretroviral therapy (ART) between October 2006 and December 2014...
October 12, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29017514/impact-of-type-2-diabetes-mellitus-on-in-hospital-mortality-after-major-cardiovascular-events-in-spain-2002-2014
#13
José M de Miguel-Yanes, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Javier de Miguel-Díez, Ana Lopez-de-Andrés
BACKGROUND: Diabetes mellitus has long been associated with cardiovascular events. Nevertheless, the higher burden of traditional cardiovascular risk factors reported in high-income countries is offset by a more widespread use of preventive measures and revascularization or other invasive procedures. The aim of this investigation is to describe trends in number of cases and outcomes, in-hospital mortality (IHM) and length of hospital stay (LHS), of hospital admissions for major cardiovascular events between type 2 diabetes (T2DM) and matched non-diabetes patients...
October 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28987239/dipeptidyl-peptidase-4-inhibitor-attenuates-obesity-induced-myocardial-fibrosis-by-inhibiting-transforming-growth-factor-%C3%AE-l-and-smad2-3-pathways-in-high-fat-diet-induced-obesity-rat-model
#14
Seul-Ki Hong, Eun-Ho Choo, Sang-Hyun Ihm, Kiyuk Chang, Ki-Bae Seung
Obesity-induced myocardial fibrosis may lead to diastolic dysfunction and ultimately heart failure. Activation of the transforming growth factor (TGF)-βl and its downstream Smad2/3 pathways may play a pivotal role in the pathogenesis of obesity-induced myocardial fibrosis, and the antidiabetic dipeptidyl peptidase 4 inhibitors (DPP4i) might affect these pathways. We investigated whether DPP4i reduces myocardial fibrosis by inhibiting the TGF-β1 and Smad2/3 pathways in the myocardium of a diet-induced obesity (DIO) rat model...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28982310/the-dipeptidyl-peptidase-iv-inhibitor-gemigliptin-alone-or-in-combination-with-nvp-auy922-has-a-cytotoxic-activity-in-thyroid-carcinoma-cells
#15
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee
The effect of the dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with the heat shock protein 90 inhibitor NVP-AUY922 (AUY922) on survival of thyroid carcinoma cells was elucidated. The SW1736 and TPC-1 human thyroid carcinoma cells were used. Cell viability, the percentage of viable cells, cytotoxic activity, the percentage of apoptotic cells, and mitochondrial membrane potential were measured. To evaluate the combined effect of gemigliptin with AUY922, the interactions were estimated by calculating combination index...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28955381/korean-guidelines-for-diagnosis-and-management-of-chronic-heart-failure
#16
REVIEW
Min-Seok Kim, Ju-Hee Lee, Eung Ju Kim, Dae-Gyun Park, Sung-Ji Park, Jin Joo Park, Mi-Seung Shin, Byung Su Yoo, Jong-Chan Youn, Sang Eun Lee, Sang Hyun Ihm, Se Yong Jang, Sang-Ho Jo, Jae Yeong Cho, Hyun-Jai Cho, Seonghoon Choi, Jin-Oh Choi, Seong Woo Han, Kyung Kuk Hwang, Eun Seok Jeon, Myeong-Chan Cho, Shung Chull Chae, Dong-Ju Choi
The prevalence of heart failure (HF) is skyrocketing worldwide, and is closely associated with serious morbidity and mortality. In particular, HF is one of the main causes for the hospitalization and mortality in elderly individuals. Korea also has these epidemiological problems, and HF is responsible for huge socioeconomic burden. However, there has been no clinical guideline for HF management in Korea. 
The present guideline provides the first set of practical guidelines for the management of HF in Korea and was developed using the guideline adaptation process while including as many data from Korean studies as possible...
September 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28945135/hospital-admissions-in-people-with-alzheimer-s-disease-or-senile-dementia-according-to-type-2-diabetes-status-an-observational-10-year-study
#17
José M de Miguel-Yanes, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Javier de Miguel-Díez, Nuria Muñoz-Rivas, David Ezpeleta, Ana López-de-Andrés
We aimed to describe admission rates and outcomes of hospitalized people with Alzheimer's disease (AD) or senile dementia stratified by type 2 diabetes (T2D) in Spain, 2004 to 2013 (N = 541 858, 143 501 [26.5%] of whom had T2D). We excluded alternative causes of dementia. Hospitalization rates were higher in people with T2D (130.5 vs 91.5 cases/10(5) people). People older than 84 years and comorbidity increased over time. Crude inhospital mortality (IHM) decreased over time both in people with and without T2D (all P values <...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28924292/hemimegalencephaly-with-intractable-epilepsy-a-case-report
#18
Prem Chand, Muhammad Faraz Raghib, Muhammad Sohail Salat, Fazal Manzoor Arain
Isolated Hemimegalencephaly (iHME) is a rare form of congenital malformation of cortical development.It is characterized by enlargement of all or part of one cerebral hemisphere. It typically presents with intractable seizures, mental retardation, developmental delay, contralateral hemiparesis and hemianopia. The patient was a five and half month's old baby girl who presented first with focal seizures at 10th day of life. No other physical or behavioral abnormality was noted. However, Initial EEG showed excessive sharp EEG transients more over the right hemisphere, repeated EEG showed spikes, polyspikes, sharps and slow wave discharges predominately over right hemisphere...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28916969/comparison-of-platelet-lymphocyte-ratio-and-ca-19-9-in-differentiating-benign-from-malignant-head-masses-in-patients-with-chronic-pancreatitis
#19
Shanavas Kakkat, Ramesh Rajan, R S Sindhu, Bonny Natesh, S Raviram
INTRODUCTION: Pancreatic head ductal adenocarcinoma (PDAC) and inflammatory head masses (IHM) related to chronic pancreatitis are often difficult to differentiate. PDAC produces significant inflammatory response with resultant lymphopenia and thrombocytosis. The prognostic role of platelet-lymphocyte ratio (PLR) as a tumor marker has been defined. We aimed to find the role of PLR as a diagnostic marker for PDAC in differentiating benign head mass comparing with carbohydrate antigen 19-9 (CA 19-9)...
July 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28899401/the-impact-of-preload-on-3-dimensional-deformation-parameters-principal-strain-twist-and-torsion
#20
Hyo-Suk Ahn, Yong-Kyun Kim, Ho Chul Song, Euy Jin Choi, Gee-Hee Kim, Jung Sun Cho, Sang-Hyun Ihm, Hee-Yeol Kim, Chan Seok Park, Ho-Joong Youn
BACKGROUND: Strain analysis is feasible using three-dimensional (3D) echocardiography. This approach provides various parameters based on speckle tracking analysis from one full-volume image of the left ventricle; however, evidence for its volume independence is still lacking. METHODS: Fifty-eight subjects who were examined by transthoracic echocardiography immediately before and after hemodialysis (HD) were enrolled. Real-time full-volume 3D echocardiographic images were acquired and analyzed using dedicated software...
September 12, 2017: Cardiovascular Ultrasound
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