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https://www.readbyqxmd.com/read/28413632/is-in-vivo-laparoscopic-simulation-learning-a-step-forward-in-the-undergraduate-surgical-education
#1
Panteleimon Pantelidis, Michail Sideris, Georgios Tsoulfas, Efstratia-Maria Georgopoulou, Ismini Tsagkaraki, Nikolaos Staikoglou, Georgios Stagias, Nikolaos Psychalakis, Parmenion Tsitsopoulos, Thanos Athanasiou, Georgios Zografos, Apostolos Papalois
BACKGROUND: Essentials Skills in the Management of Surgical Cases - ESMSC is an International Combined Applied Surgical Science and Wet Lab course addressed at the Undergraduate level. Laparoscopic Skills is a fundamental element of Surgical Education and various Simulation-Based Learning (SBL) models have been endorsed. This study aims to explore if there is any significant difference in delegates' performance depending on whether they completed In Vivo module prior to the equivalent in the laparoscopic simulator...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28410509/effects-of-atmospheric-reactive-phosphorus-deposition-on-phosphorus-transport-in-a-subtropical-watershed-a-chinese-case-study
#2
Yang Gao, Zhuo Hao, Tiantian Yang, Nianpeng He, Xuefa Wen, Guirui Yu
Atmospheric phosphorus (P) deposition is not only an important external macronutrient source for aquatic ecosystems but also a major cause of high export coefficient (EC) values. However, there are limited numbers of studies in the literature that focus on estimating the deposition flux of reactive P (Pr). The aim of this study is to estimate the Pr deposition on the Xiangxi River watershed, and therefore, provide a comprehensive understanding about the Pr deposition on subtropical watersheds in China. Results have shown that maximal Pr deposition fluxes reached 12 kg km(-2) in our selected subtropical watershed...
April 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28393754/not-all-dietary-diversity-scores-can-legitimately-be-interpreted-as-proxies-of-diet-quality-corrigendum
#3
Eric Verger, Marie-Claude Dop, Yves Martin-Prevel
No abstract text is available yet for this article.
April 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28383522/investigating-starch-gelatinization-through-stokes-vector-resolved-second-harmonic-generation-microscopy
#4
Nirmal Mazumder, Lu Yun Xiang, Jianjun Qiu, Fu-Jen Kao
The changes of the morphology during heating and the degree of crystallinity of dry and hydrated starch granules are investigated using second harmonic generation (SHG) based Stokes polarimetry. A spatial distribution of various polarization parameters, such as the degree of polarization (DOP), the degree of linear polarization (DOLP), and the degree of circular polarization (DOCP) are extracted and compared with the two dimensional second harmonic (SH) Stokes images of starch granules. The SH signal from hydrated and dry starch on heating differed significantly in DOLP and DOCP values, indicating that hydrated starch has a greater degree of ultrastructural amylopectin disorder...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380813/simplex-coded-polarization-optical-time-domain-reflectometry-system
#5
Chaodong Wang, Ruolin Liao, Wenbo Chen, Ming Tang, Songnian Fu, Jianguan Tang, Ciming Zhou, Deming Liu
In polarization optical time domain reflectometry (POTDR) system, the performance of polarimetric measurement is constrained by the low signal to noise ratio (SNR) due to the weak Rayleigh backscattering and the degradation of the degree of polarization (DOP) of signal light. Therefore, it is indispensable to improve the SNR without sacrificing the DOP of backscattered signal for a sufficient dynamic range. In this paper, a Simplex coded POTDR (sc-POTDR) system is proposed and demonstrated. The relationships between the signal's DOP and coding length/bit width are studied...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28375237/6-5%C3%A2-%C3%A2-ghz-linearly-polarized-kilowatt-fiber-amplifier-based-on-active-polarization-control
#6
Yanshan Wang, Yujun Feng, Xiaojun Wang, Hong Yan, Jue Peng, Wanjing Peng, Yinhong Sun, Yi Ma, Chun Tang
The polarization-dependent transverse mode properties in a few-mode nonpolarization-maintaining (non-PM) fiber amplifier with PM fiber laser seeding are investigated. In addition, the effect of spectral broadening on degeneration of the degree of polarization (DOP) is studied. The experimental results show that a high DOP can be achieved if the output laser of the non-PM fiber amplifier has good beam quality and a narrow linewidth without any broadening. A kilowatt (kW) fiber laser system with PM fiber seed and a non-PM fiber amplifier is demonstrated with the DOP at around 90% by controlling the beam quality and spectrum broadening...
April 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28368122/synthesis-and-evaluation-of-a-64-cu-conjugate-a-selective-%C3%AE-opioid-receptor-positron-emission-tomography-imaging-agent
#7
Azadeh Pirisedigh, Véronique Blais, Samia Ait-Mohand, Khaled Abdallah, Brian J Holleran, Richard Leduc, Yves L Dory, Louis Gendron, Brigitte Guérin
Given the putative selectivity of the antagonist TIPP (Tyr-Tic-Phe-Phe) for δ-opioid receptors (DOP), this compound was selected for the design of a novel (64)Cu-radiolabeled potent and selective DOP positron emission tomography (PET) imaging agent. Ex vivo autoradiography of TIPPD-PEG-K(NOTA/(64)Cu)-NH2 on rat brain sections produced a distribution pattern consistent with the known expression of DOP. Taken together, the in vitro and ex vivo data indicate that this (64)Cu-tracer holds promise for studying the DOP by means of PET...
April 3, 2017: Organic Letters
https://www.readbyqxmd.com/read/28366440/progressive-learning-in-endoscopy-simulation-training-improves-clinical-performance-a-blinded-randomized-trial
#8
Samir C Grover, Michael A Scaffidi, Rishad Khan, Ankit Garg, Ahmed Al-Mazroui, Tareq Alomani, Jeffrey J Yu, Ian S Plener, Mohamed Al-Awamy, Elaine L Yong, Maria Cino, Nikila C Ravindran, Mark Zasowski, Teodor P Grantcharov, Catharine M Walsh
BACKGROUND AND AIMS: A structured comprehensive curriculum (SCC) using simulation-based training (SBT) can improve clinical colonoscopy performance. This curriculum may be enhanced through the application of progressive learning, a training strategy centered on incrementally challenging learners. We aimed to determine whether a progressive learning-based curriculum (PLC) would lead to superior clinical performance compared with an SCC. METHODS: This was a single-blinded randomized controlled trial conducted at a single academic center...
March 30, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28365552/nitrate-reduction-in-water-by-aluminum-alloys-particles
#9
Zunsheng Bao, Qing Hu, Weikang Qi, Yang Tang, Wei Wang, Pingyu Wan, Jingbo Chao, Xiao Jin Yang
Nano zero-valent iron (NZVI) particles have been extensively investigated for nitrate reduction in water. However, the reduction by NZVI requires acidic pH conditions and the final product is exclusively ammonium, leading to secondary contamination. In addition, nanomaterials have potential threats to environment and the transport and storage of nanomaterials are of safety concerns. Aluminum, the most abundant metal element in the earth's crust, is able to reduce nitrate, but the passivation of aluminum limits its application...
March 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28363796/structure-constrained-endomorphin-analogs-display-differential-antinociceptive-mechanisms-in-mice-after-spinal-administration
#10
Yuan Wang, Jingjing Zhou, Xin Liu, Long Zhao, Zhaojuan Wang, Xianghui Zhang, Kezhou Wang, Linqing Wang, Rui Wang
We previously reported a series of novel endomorphin analogs with unnatural amino acid modifications. These analogs display good binding affinity and functional activity toward the μ opioid receptor (MOP). In the present study, we further investigated the spinal antinociceptive activity of these compounds. The analogs were potent in several nociceptive models. Opioid antagonists and antibodies against several endogenous opioid peptides were used to determine the mechanisms of action of these peptides. Intrathecal pretreatment with naloxone and β-funaltrexamine (β-FNA) effectively inhibited analog-induced analgesia, demonstrating that activity of the analogs is regulated primarily through MOP...
March 29, 2017: Peptides
https://www.readbyqxmd.com/read/28349862/dopamine-signaling-tunes-spatial-pattern-selectivity-in-c-elegans
#11
Bicheng Han, Yongming Dong, Lin Zhang, Yan Liu, Ithai Rabinowitch, Jihong Bai
Animals with complex brains can discriminate the spatial arrangement of physical features in the environment. It is unknown whether such sensitivity to spatial patterns can be accomplished in simpler nervous systems that lack long-range sensory modalities such as vision and hearing. Here we show that the nematode Caenorhabditis elegans can discriminate spatial patterns in its surroundings, despite having a nervous system of only 302 neurons. This spatial pattern selectivity requires touch-dependent dopamine signaling, including the mechanosensory TRP-4 channel in dopaminergic neurons and the D2-like dopamine receptor DOP-3...
March 28, 2017: ELife
https://www.readbyqxmd.com/read/28339750/downstream-overdrive-pacing-and-intracardiac-concealed-fusion-to-guide-rapid-identification-of-atrial-tachycardia-after-atrial-fibrillation-ablation
#12
Chirag R Barbhaiya, Samuel H Baldinger, Saurabh Kumar, Jason S Chinitz, Alan D Enriquez, Roy John, William G Stevenson, Gregory F Michaud
Aims: Atrial tachycardia (AT) related to atrial fibrillation (AF) ablation frequently poses a diagnostic challenge. Downstream overdrive pacing (DOP) can be used to rapidly detect reentry and assess proximity of a pacing site to an AT circuit or focus. We hypothesized that systematic DOP using multielectrode catheters would facilitate AT mapping. Methods and results: DOP identified constant fusion when the post-pacing interval (PPI)-tachycardia cycle length (TCL) <40 ms and stimulus to adjacent upstream atrial electrogram interval >75% of TCL...
February 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28327600/dopamine-functionalized-tannic-acid-templated-mesoporous-silica-nanoparticles-as-a-new-sorbent-for-the-efficient-removal-of-cu-2-from-aqueous-solution
#13
Junkai Gao, Hao Lei, Zhi Han, Qian Shi, Yan Chen, Yanjun Jiang
A simple, environmentally friendly and cost-effective nonsurfactant template method was used to synthesize tannic-acid-templated mesoporous silica nanoparticles (TMSNs), and then dopamine functionalized TMSNs (Dop-TMSNs) which was synthesized by a facile and biomimetic coating strategy, was developed as a new sorbent for the removal of Cu(2+) from aqueous solution. The Dop-TMSNs were thoroughly characterized by SEM, TEM, BET, FT-IR and TGA, and the effects of contact time, initial pH, K(+) and Na(+) concentrations, co-existing polyvalent metal ions and adsorption-desorption cycle times on the sorption capacity of Dop-TMSNs were studied...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314390/oxysterols-in-cosmetics-determination-by-planar-solid-phase-extraction-and-gas-chromatography-mass-spectrometry
#14
S Schrack, C Hohl, W Schwack
Sterol oxidation products (SOPs) are linked to several toxicological effects. Therefore, investigation of potential dietary uptake sources particularly food of animal origin has been a key issue for these compounds. For the simultaneous determination of oxysterols from cholesterol, phytosterols, dihydrolanosterol and lanosterol in complex cosmetic matrices, planar solid phase extraction (pSPE) was applied as clean-up tool. SOPs were first separated from more non-polar and polar matrix constituents by normal phase thin-layer chromatography and then focussed into one target zone...
November 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28314114/st-sub-2-sub-80-a-new-fish-marker-for-st-genome-and-genome-analysis-in-triticeae
#15
Long Wang, Qinghua Shi, Handong Su, Yi Wang, Sha Lina, Xing Fan, Kang Houyang, Zhang Haiqin, Yong-Hong Zhou
<b>St</b> genome is one of the most fundamental genomes in Triticeae. Repetitive sequences are widely used to distinguish different genomes or species. The primary objectives of this study are (1) to screen a new sequence that can easily distinguish the chromosome of <b>St</b> and other genome by fluorescence in situ hybridization (FISH); (2) to investigate the genome constitutions of some species remains uncertain and controversial. We used degenerated oligonucleotide primer PCR (Dop-PCR), Dot-blot and FISH to screen new marker for <b>St</b> genome and tested efficiency of this marker in detection <b>St</b> chromosome at different ploidy level...
March 17, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28294540/traditional-chinese-medicine-bushen-jianpi-huoxue-decoction-prevents-diabetic-osteoporosis-in-rats-via-wnt-and-nuclear-factor-kappa-b-signaling-pathways
#16
Yongqing Zhang, Mingming Liu, Haisheng Li, Zetao Chen, Na Liang, Jianguo Xu, Xiaoli Zhang, Yihang Zhang
AIM: The aim of this study was to evaluate the therapeutic effect of a traditional Chinese medicine (TCM), Bushen-Jianpi-Huoxue decoction (BJHD), on diabetic osteoporosis (DOP) and the action mechanisms likely mediated by nuclear factor-kappa B (NF-κB) and Wnt signaling pathways. METHODS: Fifty-five male Wistar rats were used in this study; they were divided into normal control (n = 10) and established DOP model (n = 45) groups. The DOP model was induced using a combination high carbohydrate - high fat diet and intraperitoneal injections of streptozotocin (STZ)...
March 13, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28286835/role-of-feedback-during-evaluation-in-improving-emergency-medicine-residents-skills-an-experimental-study
#17
Ali Vafaei, Kamran Heidari, Mohammad-Ali Hosseini, Mostafa Alavi-Moghaddam
INTRODUCTION: Evaluation of students' learning in clinical education system is one of the most important and challenging issues that facilities in this field have been facing. The present study aimed to evaluate the role of feedback during evaluation in increasing emergency medicine residents' clinical skills. METHOD: The present experimental study was performed on all second year emergency medicine residents of two educational hospitals, Tehran, Iran, with switching replications design and before-after method...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28223451/mycobacterium-tuberculosis-proteasome-accessory-factor-a-pafa-can-transfer-prokaryotic-ubiquitin-like-protein-pup-between-substrates
#18
Susan Zhang, Kristin E Burns-Huang, Guido V Janssen, Huilin Li, Huib Ovaa, Lizbeth Hedstrom, K Heran Darwin
The protein degradation machinery of Mycobacterium tuberculosis includes a proteasome and a ubiquitin-like protein (Pup). Proteasome accessory factor A (PafA) attaches Pup to proteins to target them for degradation by the proteasome. Free Pup is unstable and never observed in extracts of M. tuberculosis, an observation that led us to hypothesize that PafA may need alternative sources of Pup. Here, we show that PafA can move Pup from one proteasome substrate, inositol 1-phosphate synthetase (Ino1), to two different proteins, malonyl coenzyme A (CoA)-acyl carrier protein transacylase (FabD) and lonely guy (Log)...
February 21, 2017: MBio
https://www.readbyqxmd.com/read/28213383/development-of-a-direct-observation-of-procedural-skills-rubric-for-fourth-year-pharmacy-students-in-ambulatory-care-rotations
#19
Sara J Linedecker, Jamie Barner, Jennifer Ridings-Myhra, Aida Garza, Debra Lopez, William McIntyre
PURPOSE: The development and implementation of a pilot program requiring direct observation of procedural skills (DOPS) assessments of fourth-year pharmacy students during ambulatory care rotations are described. METHODS: All fourth-year pharmacy students at the University of Texas at Austin College of Pharmacy who engaged in a required advanced pharmacy practice experience (APPE) in ambulatory care during the period January-May 2015 participated in a DOPS pilot program...
March 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28192197/characterization-of-3-h-oxymorphone-binding-sites-in-mouse-brain-quantitative-autoradiography-in-opioid-receptor-knockout-mice
#20
Ji Hoon Yoo, Anna Borsodi, Géza Tóth, Sándor Benyhe, Robert Gaspar, Audrey Matifas, Brigitte L Kieffer, Athanasios Metaxas, Ian Kitchen, Alexis Bailey
Oxymorphone, one of oxycodone's metabolic products, is a potent opioid receptor agonist which is thought to contribute to the analgesic effect of its parent compound and may have high potential abuse liability. Nonetheless, the in vivo pharmacological binding profile of this drug is still unclear. This study uses mice lacking mu (MOP), kappa (KOP) or delta (DOP) opioid receptors as well as mice lacking all three opioid receptors to provide full characterisation of oxymorphone binding sites in the brain. Saturation binding studies using [(3)H]oxymorphone revealed high affinity binding sites in mouse brain displaying Kd of 1...
March 16, 2017: Neuroscience Letters
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