keyword
MENU ▼
Read by QxMD icon Read
search

DOPS

keyword
https://www.readbyqxmd.com/read/28636344/ruthenium-complexes-are-ph-activated-metallo-prodrugs-phamps-with-light-triggered-selective-toxicity-toward-cancer-cells
#1
Fengrui Qu, Seungjo Park, Kristina Martinez, Jessica L Gray, Fathima Shazna Thowfeik, John A Lundeen, Ashley E Kuhn, David J Charboneau, Deidra L Gerlach, Molly M Lockart, James A Law, Katherine L Jernigan, Nicole Chambers, Matthias Zeller, Nicholas A Piro, W Scott Kassel, Russell H Schmehl, Jared J Paul, Edward J Merino, Yonghyun Kim, Elizabeth T Papish
Metallo prodrugs that take advantage of the inherent acidity surrounding cancer cells have yet to be developed. We report a new class of pH-activated metallo prodrugs (pHAMPs) that are activated by light- and pH-triggered ligand dissociation. These ruthenium complexes take advantage of a key characteristic of cancer cells and hypoxic solid tumors (acidity) that can be exploited to lessen the side effects of chemotherapy. Five ruthenium complexes of the type [(N,N)2Ru(PL)](2+) were synthesized, fully characterized, and tested for cytotoxicity in cell culture (1A: N,N = 2,2'-bipyridine (bipy) and PL, the photolabile ligand, = 6,6'-dihydroxybipyridine (6,6'-dhbp); 2A: N,N = 1,10-phenanthroline (phen) and PL = 6,6'-dhbp; 3A: N,N = 2,3-dihydro-[1,4]dioxino[2,3-f][1,10]phenanthroline (dop) and PL = 6,6'-dhbp; 4A: N,N = bipy and PL = 4,4'-dimethyl-6,6'-dihydroxybipyridine (dmdhbp); 5A: N,N = 1,10-phenanthroline (phen) and PL = 4,4'-dihydroxybipyridine (4,4'-dhbp)...
June 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28605872/characteristics-of-dissolved-organic-phosphorus-inputs-to-freshwater-lakes-a-case-study-of-lake-erhai-southwest-china
#2
Ningning Ji, Shengrui Wang, Li Zhang
In this study, we made the first estimate of the annual dissolved organic phosphorus (DOP) load to Lake Erhai, a typical mesotrophic-eutrophic lake in China. We also evaluated what proportion of DOP was bioavailable using enzymatically hydrolyzable phosphorus (EHP), and further assessed the potential impacts of DOP on lake water quality. We estimated that the annual DOP load into Lake Erhai accounted for nearly 50% of total dissolved phosphorus, while EHP accounted for about 30% of the bioavailable phosphorus (BAP) pool...
June 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28587963/a-polysaccharide-of-dendrobium-officinale-ameliorates-h2o2-induced-apoptosis-in-h9c2-cardiomyocytes-via-pi3k-akt-and-mapk-pathways
#3
Jing-Yi Zhang, Ying Guo, Jin-Ping Si, Xiao-Bo Sun, Gui-Bo Sun, Jing-Jing Liu
Dendrobium officinale is one valuable traditional Chinese medicine, which has skyscraping medicinal value. Polysaccharide is the main active ingredient in D. officinale; its antioxidant activity is a hot research topic nowadays. Oxidative stress plays an important role in the pathological progress of a variety of cardiovascular disease, as one of key factors of cardiomyocyte apoptosis. This research adopts a model of H2O2 induction-H9c2 cardiomyocytes apoptosis, aiming to study the effect of Dendrobium officinale Polysaccharide (DOP-GY) for cardiomyocyte apoptosis caused by oxidative stress and its possible mechanism...
June 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28548660/transcriptomic-and-micrornaomic-profiling-reveals-multi-faceted-mechanisms-to-cope-with-phosphate-stress-in-a-dinoflagellate
#4
Xinguo Shi, Xin Lin, Ling Li, Meizhen Li, Brian Palenik, Senjie Lin
Although gene regulation can occur at both transcriptional and epigenetic (microRNA) levels, combined transcriptomic and microRNAomic responses to environmental stress are still largely unexplored for marine plankton. Here, we conducted transcriptome and microRNAome sequencing for Prorocentrum donghaiense to understand the molecular mechanisms by which this dinoflagellate copes with phosphorus (P) deficiency. Under P-depleted conditions, G1/S specific cyclin gene was markedly downregulated, consistent with growth inhibition, and genes related to dissolved organic phosphorus (DOP) hydrolysis, carbon fixation, nitrate assimilation, glycolysis, and cellular motility were upregulated...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28521220/synthesis-of-ordered-mesoporous-la2o3-zro2-composites-with-encapsulated-pt-nps-and-the-effect-of-la-dopping-on-catalytic-activity
#5
Yan Gao, Yiwei Zhang, Yuming Zhou, Chao Zhang, Hongxing Zhang, Shuo Zhao, Jiasheng Fang, Mengqiu Huang, Xiaoli Sheng
In this work, we report a feasible approach to synthesize a ternary nanocomposites, Pt/lanthanum doped mesoporous zirconium oxide (Pt/La2O3-ZrO2), via an effective two-step method. Ordered mesoporous La2O3-ZrO2 composites were firstly fabricated with mesoporous silica KIT-6 as a hard template. Subsequently, uniform Pt nanoparticles encapsulated by 4 hydroxyl-terminated poly (amidoamine) (G4-OH PAMAM) dendrimers were deposited on the La2O3-ZrO2 composites. The as-prepared samples were characterized by transmission electron microscope (TEM), N2 adsorption-desorption isotherm analysis, energy dispersion X-ray analysis (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and temperature programmed reduction (H2-TPR)...
October 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28505508/phosphatase-activities-of-a-microepiphytic-community-during-a-bloom-of-ostreopsis-cf-ovata-in-the-northern-adriatic-sea
#6
Stefano Accoroni, Cecilia Totti, Emanuela Razza, Roberta Congestri, Alessandra Campanelli, Mauro Marini, Neil Thomas William Ellwood
It is becoming more apparent that increased organic nutrient loads deriving from anthropogenic activities and natural processes frequently cause the eutrophication of coastal waters. Concurrently, an increasing number of phototrophs have been shown to make use of organic nutrients, mainly through indirect studies of surface enzyme activities or through direct studies of growth in media containing organic-only nutrients. The potential utilization of dissolved organic phosphorus (DOP) by microepiphytic-mats associated with frequently problematic, toxic dinoflagellate Ostreopsis cf...
May 8, 2017: Water Research
https://www.readbyqxmd.com/read/28468337/spectralon-spatial-depolarization-towards-an-intrinsic-characterization-using-a-novel-phase-shift-distribution-analysis
#7
Jan Dupont, Xavier Orlik, Romain Ceolato, Thibault Dartigalongue
Spectralons are reference radiometric samples which exhibit a calibrated reflectance. However, in case of low reflectance samples, the degree of polarization (DOP) of scattered light is hard to characterize. Here, an accurate determination of spectralon spatial depolarization is proposed. Based on a spatially resolved polarimetric imaging system, the polarization state of the scattered light is characterized for every pixel. A statistic distribution analysis is carried out over the entire image. The relative phase shift distribution between two orthogonal components of the scattered electric field clearly exhibits a high sensitivity to the reflectance, the phase statistics following a circular Voigt profile...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28464102/effects-of-feeding-different-levels-of-dried-orange-pulp-and-recycled-poultry-bedding-on-the-performance-of-fattening-lambs
#8
Z Tadayon, Y Rouzbehan, J Rezaei
The effects of dietary feeding different levels of recycled poultry bedding (RPB) and dried orange pulp (DOP) on the performance of fattening Shal lambs (initial BW of 28 ± 2.2 kg) were assessed using a factorial experiment (2 × 3) with a completely randomized design. Six diets, containing different levels of RPB (0 or 160 g/kg of DM) and DOP (0, 110, or 220 g/kg of DM), were randomly assigned to 6 groups of 6 lambs each for a 74-d period (14 d for adaptation and 60 d for data collection). Diets were offered as total mixed ration to ensure 10% of orts...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28463256/multiplexed-polarization-otdr-system-with-high-dop-and-ability-of-multi-event-detection
#9
Xuefeng Wang, Chaodong Wang, Ming Tang, Songnian Fu, Perry Shum
A novel polarization optical time domain reflectometry (POTDR) with high degree of polarization is proposed for multi-event detection. By employing multiple 2×2 optical fiber couplers and fiber mirrors, an arbitrary number and customized length of sensing fiber can be multiplexed into the system without modification of the other components, e.g., the light source, photodetector, signal processing device, etc. More importantly, the signal-to-noise ratio of this system is significantly improved, and the temporal depolarization effect can be almost completely suppressed...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28460566/recognition-dynamics-of-dopamine-to-human-monoamine-oxidase-b-role-of-leu171-gln206-and-conserved-water-molecules-in-the-active-site-cavity
#10
Subrata Dasgupta, Soumita Mukherjee, Bishnu P Mukhopadhyay, Avik Banerjee, Deepak K Mishra
The human Monoamine oxidase (hMAO) metabolizes several biogenic amine neurotransmitters and is involved in different neurological disorders. Extensive MD simulation studies of dopamine-docked hMAO B structures have revealed the stabilization of amino-terminal of the substrate by a direct and water-mediated interaction of catalytic tyrosines, Gln206, and Leu171 residues. The catechol ring of the substrate is stabilized by Leu171(C-H)⋯π(Dop)⋯(H-C) Ile199 interaction. Several conserved water molecules are observed to play a role in the recognition of substrate to the enzyme, where W1 and W2 associate in dopamine- FAD interaction, reversible dynamics of W3 and W4 influenced the coupling of Tyr435 to Trp432 and FAD, and W5 and W8 stabilized the catalytic Tyr188/398 residues...
May 24, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28454075/a-novel-highly-sensitive-selective-reversible-and-turn-on-chemi-sensor-based-on-schiff-base-for-rapid-detection-of-cu-ii
#11
Sayed M Saleh, Reham Ali, Ibrahim A I Ali
In this work, a novel optical fluoro-chemisensor was designed and synthesized for copper (II) ions detection. The sensor film is created by embedded N,N-Bis(2-hydroxo-5-bromobenzyl)ethylenediamine in poly vinyl chloride (PVC) film in presence of dioctyl phthalate (DOP) as plasticizer. The receptor Schiff base reveals "off-on" mode with high selectivity, significant sensitivity to Cu(II) ions. The selectivity of optical sensor for Cu(II) ions is the result of chelation enhanced fluorescence (CHEF). The optimal conditions of pH and response time at which higher efficiency of sensor film is performed was found to be 6...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28447380/lncrna-h19-modulates-wnt-%C3%AE-catenin-signaling-by-targeting-dkk4-in-hindlimb-unloaded-rat
#12
Bing Li, Jun Liu, Jie Zhao, Jian-Xiong Ma, Hao-Bo Jia, Yang Zhang, Guo-Sheng Xing, Xin-Long Ma
OBJECTIVE: To investigate the biological functions of long noncoding RNA-H19 (H19) in the pathogenesis of disuse osteoporosis (DOP). METHODS: Fifty-four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age-matched control (AC, 24), and hindlimb unloading (HLU, 24). The rats in the BC group were sacrificed at the beginning of the experiment, while the AC and HLU rats were sacrificed at different times (7, 14, 21 and 28 days after HLU)...
April 26, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28413632/is-in-vivo-laparoscopic-simulation-learning-a-step-forward-in-the-undergraduate-surgical-education
#13
Panteleimon Pantelidis, Michail Sideris, Georgios Tsoulfas, Efstratia-Maria Georgopoulou, Ismini Tsagkaraki, Nikolaos Staikoglou, Georgios Stagias, Nikolaos Psychalakis, Parmenion Tsitsopoulos, Thanos Athanasiou, Georgios Zografos, Apostolos Papalois
BACKGROUND: Essentials Skills in the Management of Surgical Cases - ESMSC is an International Combined Applied Surgical Science and Wet Lab course addressed at the Undergraduate level. Laparoscopic Skills is a fundamental element of Surgical Education and various Simulation-Based Learning (SBL) models have been endorsed. This study aims to explore if there is any significant difference in delegates' performance depending on whether they completed In Vivo module prior to the equivalent in the laparoscopic simulator...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28410509/effects-of-atmospheric-reactive-phosphorus-deposition-on-phosphorus-transport-in-a-subtropical-watershed-a-chinese-case-study
#14
Yang Gao, Zhuo Hao, Tiantian Yang, Nianpeng He, Xuefa Wen, Guirui Yu
Atmospheric phosphorus (P) deposition is not only an important external macronutrient source for aquatic ecosystems but also a major cause of high export coefficient (EC) values. However, there are limited numbers of studies in the literature that focus on estimating the deposition flux of reactive P (Pr). The aim of this study is to estimate the Pr deposition on the Xiangxi River watershed, and therefore, provide a comprehensive understanding about the Pr deposition on subtropical watersheds in China. Results have shown that maximal Pr deposition fluxes reached 12 kg km(-2) in our selected subtropical watershed...
April 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28393754/not-all-dietary-diversity-scores-can-legitimately-be-interpreted-as-proxies-of-diet-quality-corrigendum
#15
Eric Verger, Marie-Claude Dop, Yves Martin-Prevel
No abstract text is available yet for this article.
April 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28383522/investigating-starch-gelatinization-through-stokes-vector-resolved-second-harmonic-generation-microscopy
#16
Nirmal Mazumder, Lu Yun Xiang, Jianjun Qiu, Fu-Jen Kao
The changes of the morphology during heating and the degree of crystallinity of dry and hydrated starch granules are investigated using second harmonic generation (SHG) based Stokes polarimetry. A spatial distribution of various polarization parameters, such as the degree of polarization (DOP), the degree of linear polarization (DOLP), and the degree of circular polarization (DOCP) are extracted and compared with the two dimensional second harmonic (SH) Stokes images of starch granules. The SH signal from hydrated and dry starch on heating differed significantly in DOLP and DOCP values, indicating that hydrated starch has a greater degree of ultrastructural amylopectin disorder...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380813/simplex-coded-polarization-optical-time-domain-reflectometry-system
#17
Chaodong Wang, Ruolin Liao, Wenbo Chen, Ming Tang, Songnian Fu, Jianguan Tang, Ciming Zhou, Deming Liu
In polarization optical time domain reflectometry (POTDR) system, the performance of polarimetric measurement is constrained by the low signal to noise ratio (SNR) due to the weak Rayleigh backscattering and the degradation of the degree of polarization (DOP) of signal light. Therefore, it is indispensable to improve the SNR without sacrificing the DOP of backscattered signal for a sufficient dynamic range. In this paper, a Simplex coded POTDR (sc-POTDR) system is proposed and demonstrated. The relationships between the signal's DOP and coding length/bit width are studied...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28375237/6-5%C3%A2-%C3%A2-ghz-linearly-polarized-kilowatt-fiber-amplifier-based-on-active-polarization-control
#18
Yanshan Wang, Yujun Feng, Xiaojun Wang, Hong Yan, Jue Peng, Wanjing Peng, Yinhong Sun, Yi Ma, Chun Tang
The polarization-dependent transverse mode properties in a few-mode nonpolarization-maintaining (non-PM) fiber amplifier with PM fiber laser seeding are investigated. In addition, the effect of spectral broadening on degeneration of the degree of polarization (DOP) is studied. The experimental results show that a high DOP can be achieved if the output laser of the non-PM fiber amplifier has good beam quality and a narrow linewidth without any broadening. A kilowatt (kW) fiber laser system with PM fiber seed and a non-PM fiber amplifier is demonstrated with the DOP at around 90% by controlling the beam quality and spectrum broadening...
April 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28368122/synthesis-and-evaluation-of-a-64-cu-conjugate-a-selective-%C3%AE-opioid-receptor-positron-emission-tomography-imaging-agent
#19
Azadeh Pirisedigh, Véronique Blais, Samia Ait-Mohand, Khaled Abdallah, Brian J Holleran, Richard Leduc, Yves L Dory, Louis Gendron, Brigitte Guérin
Given the putative selectivity of the antagonist TIPP (Tyr-Tic-Phe-Phe) for δ-opioid receptors (DOP), this compound was selected for the design of a novel (64)Cu-radiolabeled potent and selective DOP positron emission tomography (PET) imaging agent. Ex vivo autoradiography of TIPPD-PEG-K(NOTA/(64)Cu)-NH2 on rat brain sections produced a distribution pattern consistent with the known expression of DOP. Taken together, the in vitro and ex vivo data indicate that this (64)Cu-tracer holds promise for studying the DOP by means of PET...
April 3, 2017: Organic Letters
https://www.readbyqxmd.com/read/28366440/progressive-learning-in-endoscopy-simulation-training-improves-clinical-performance-a-blinded-randomized-trial
#20
Samir C Grover, Michael A Scaffidi, Rishad Khan, Ankit Garg, Ahmed Al-Mazroui, Tareq Alomani, Jeffrey J Yu, Ian S Plener, Mohamed Al-Awamy, Elaine L Yong, Maria Cino, Nikila C Ravindran, Mark Zasowski, Teodor P Grantcharov, Catharine M Walsh
BACKGROUND AND AIMS: A structured comprehensive curriculum (SCC) using simulation-based training (SBT) can improve clinical colonoscopy performance. This curriculum may be enhanced through the application of progressive learning, a training strategy centered on incrementally challenging learners. We aimed to determine whether a progressive learning-based curriculum (PLC) would lead to superior clinical performance compared with an SCC. METHODS: This was a single-blinded randomized controlled trial conducted at a single academic center...
March 30, 2017: Gastrointestinal Endoscopy
keyword
keyword
56824
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"