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Bing Li, Jie Zhao, Jian-Xiong Ma, Guo-Min Li, Yang Zhang, Guo-Sheng Xing, Jun Liu, Xin-Long Ma
Disuse osteoporosis (DOP) is a common complication of the lack of mechanical loading. The precise mechanism underlying DOP remains unknown, although epigenetic modifications may be a major cause. Recently, cumulative research has revealed that DNA methyltransferase (DNMT) proteins can catalyze the conversion of cytosine to 5-methylcytosine (5mC), altering the epigenetic state of DNA. Here, we report that DNMT1 expression and lncRNA-H19 methylation are upregulated in the femoral tissues of DOP rats, accompanied with inhibited Erk signaling pathway...
March 16, 2018: Bone
Mingfeng Ning, Shijie Zhang, Shiqiang Wang
The number of feature points on the surface of a non-cooperative target satellite used for monocular vision-based relative navigation affects the onboard computational load. A feature point selection method called the quasi-optimal method is proposed to select a subset of feature points with a good geometric distribution. This method, with the assumption that all of the feature points are in a plane and have the same variance, is based on the fact that the scattered feature points can provide higher accuracy than that of them grouped together...
March 14, 2018: Sensors
Gamal A Shazly, Sultan Alshehri, Mohamed A Ibrahim, Hesham M Tawfeek, Jelan A Razik, Yasser A Hassan, Faiyaz Shakeel
Domperidone (DOP) is extensively applied orally in the management of nausea and vomiting. Upon oral administration, its bioavailability is very poor due to its poor solubility in alkaline media. Therefore, the aim of this work was to investigate DOP-loaded solid lipid nanoparticles (DOP-SLNs) in order to sustain its release pattern and to enhance oral bioavailability. DOP-SLNs were prepared using four different lipids. Prepared DOP-SLNs were characterized for "polydispersity index (PDI), particle size, zeta potential, % entrapment efficiency (% EE), and drug release behavior...
March 12, 2018: AAPS PharmSciTech
Wenqiang Zhang, Xin Jin, Xin Meng, Wenzhong Tang, Baoqing Shan
We studied the processes and mechanisms that drove phosphorus (P) release and transformations at the sediment-water interface (SWI) because of the decomposition of plant debris. The results showed that, as the simulation time increased, the pH, dissolved oxygen (DO), and oxidation reduction potential (ORP) in Duckweed+Sediment+Water (DWS) and Duckweed+Water (DW) initially decreased and then increased before stabilizing. Changes in the physicochemical characteristics affect the microhabitat and the release and transformations of P at the SWI...
March 3, 2018: Chemosphere
Kris Rutten, Wolfgang Schröder, Thomas Christoph, Thomas Koch, Thomas M Tzschentke
Agonists selectively acting at NOP, MOP, DOP and KOP receptors as well as mixed opioid receptor agonists are known to exert anti-hypersensitive efficacy in the rat spinal nerve ligation (SNL) model of neuropathic pain. To investigate the relative contribution of individual opioid receptor activation to the overall efficacy of mixed opioid receptor agonists, selective doses of respective opioid receptor antagonists have to be employed. In order to identify such selective antagonist doses, doses of the selective NOP, MOP, DOP and KOP receptor agonists Ro65-6570, morphine, SNC-80 and U50488H, that produced maximum efficacy without apparent side effects, were challenged by each of the receptor antagonists J-113397 (NOP receptor), naloxone (MOP receptor), naltrindole (DOP receptor) and nor-binaltorphimine (KOP receptor)...
March 7, 2018: European Journal of Pharmacology
N Dietis, H Niwa, R Tose, J McDonald, V Ruggieri, M Filaferro, G Vitale, L Micheli, C Ghelardini, S Salvadori, G Calo, R Guerrini, D J Rowbotham, D G Lambert
BACKGROUND AND PURPOSE: Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reduced side effect profile. We have evaluated the mixed MOP (μ, mu) agonist/DOP (δ, delta) antagonist UFP-505 in vitro and in vivo. EXPERIMENTAL APPROACH: We measured receptor density and function in single MOP, DOP and MOP/DOP double expression systems. GTPγ35 S binding, cAMP formation and arrestin recruitment were measured. Antinociceptive activity was measured in vivo using tail withdrawal and paw pressure tests following acute and chronic treatment...
March 10, 2018: British Journal of Pharmacology
Eleanor Evans, Chania Lambrinudi
No abstract text is available yet for this article.
March 7, 2018: Medical Teacher
Weiping Lin, Ao Liu, Caihong Weng, Hui Li, Shiwei Sun, Aihuan Song, Hu Zhu
Phenylalanine ammonia-lyase (PAL) gene plays an important role in the synthesis of flavones, lignin, and other bioactive compounds in living organisms. Inonotus baumii, the only known flavone-producing filamentous fungus, is of great importance in the investigation of flavone metabolic pathways. To study the function of PAL enzyme in I. baumii flavone synthesis, a full-length cDNA of pal gene was cloned from I. baumii using DOP-PCR and RACE-PCR. The 2502-bp PAL coding region encodes an 833 amino acid protein with an approximate MW of 88...
May 2018: Enzyme and Microbial Technology
Victoria Plaza, Michael Molina, Luis J Fuentes, Angeles F Estévez
It has recently been reported that the differential outcomes procedure (DOP) might be one of the therapeutical techniques focused at promoting autonomy in the elderly to deal with their medical issues. Molina et al. (2015) found that a group of healthy young adults improved their learning and long-term retention of six disorder/pill associations when each relationship to be learned was associated with a particular reinforcer (the differential outcomes condition) compared to when they were randomly administered (the non-differential outcomes condition)...
2018: Frontiers in Psychology
Mónica Rouco, Kyle R Frischkorn, Sheean T Haley, Harriet Alexander, Sonya T Dyhrman
The N2 -fixing cyanobacterium Trichodesmium is intensely studied because of the control this organism exerts over the cycling of carbon and nitrogen in the low nutrient ocean gyres. Although iron (Fe) and phosphorus (P) bioavailability are thought to be major drivers of Trichodesmium distributions and activities, identifying resource controls on Trichodesmium is challenging, as Fe and P are often organically complexed and their bioavailability to a single species in a mixed community is difficult to constrain...
February 28, 2018: ISME Journal
Jason Guey, S Rodrigues, A Pullen, B Shaw, D C Kieser
PURPOSE: Ballistic gelatin is commonly used as a validated surrogate for soft tissue during terminal ballistic testing. However, the effect of a delay between production and testing of a gelatin mould remains unknown. The aim of this study was to determine any potential effects of ageing on ballistic gelatin. METHODS: Depth of penetration (DoP) of 4.5 mm spherical fragment simulating projectiles was ascertained using mixtures of 10%, 11.25% and 20% Type A 250 Bloom ballistic gelatin...
February 27, 2018: Journal of the Royal Army Medical Corps
Akiyoshi Saitoh, Hiromu Tominaga, Yasuhiro Ogawa, Yoko Irukayama-Tomobe, Mitsuhiko Yamada, Masashi Yanagisawa, Hiroshi Nagase
BACKGROUND: We previously reported that the novel selective delta opioid receptor (DOP) agonist KNT-127 did not cause convulsions in mice, whereas the prototype DOP agonist SNC80 did. Previous studies have reported that SNC80 caused electroencephalographic (EEG) disturbances in rodents. However, whether KNT-127 affects EEG responses is unknown. Therefore, the present study aimed to compare the effect of KNT-127 on EEG responses with that of SNC80 in mice. METHODS: For behavioral experiments, male C57BL6/J mice were injected intraperitoneally with either KNT-127 (30 mg/kg) or SNC80 (30 mg/kg) and monitored for convulsions and subsequent catalepsy-like behavior for 10 min immediately after drug treatment...
October 28, 2017: Pharmacological Reports: PR
Ke Zhang, Yihao Liu, Qiang Chen, Hongbing Luo, Zhanyuan Zhu, Wei Chen, Jia Chen, You Mo
Two bacterial strains designated as Arthrobacter sp. SLG-4 and Rhodococcus sp. SLG-6, capable of utilizing di-n-octyl phthalate (DOP) as sole source of carbon and energy, were isolated from activated sludge. The analysis of DOP degradation intermediates indicated Arthrobacter sp. SLG-4 could completely degrade DOP. Whereas DOP could not be mineralized by Rhodococcus sp. SLG-6 and the final metabolic product was phthalic acid (PA). The proposed DOP degradation pathway by Arthrobacter sp. SLG-4 was that strain SLG-4 initially transformed DOP to PA via de-esterification pathway, and then PA was metabolized to protocatechuate acid and eventually converted to tricarboxylic acid (TCA) cycle through meta-cleavage pathway...
February 15, 2018: Biodegradation
Shinya Kato, Tetsuro Yoshimura, Nobuhiko Miwa
The polyhydroxy small-gap fullerenes [C120O30(OH)30 · 30H2O · 25Na+: SGFs] were encapsulated in multilamellar liposomes (Lpsm) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phospho-l-serine (DOPS), which are designated as LpsmSGFs (DOPC/DOPS/SGFs = 35 mM:15 mM:246-445 μM, diameter = 141.2 nm, ζ-potential = -35.65 mV). Radiosensitization by LpsmSGFs under X-ray irradiation was evaluated on human melanoma HMV-II cells. On 7th day after X-ray irradiation, cell proliferation degree assessed by WST-8 decreased more markedly on cells pretreated with LpsmSGFs than Lpsm or free-SGFs...
June 1, 2018: Journal of Nanoscience and Nanotechnology
Jian Liang, Shuxian Chen, Jianhui Chen, Jizong Lin, Qingping Xiong, Yiqi Yang, Jun Yuan, Lian Zhou, Lian He, Shaozhen Hou, Shijie Li, Song Huang, Xiaoping Lai
Polysaccharide, as a promising candidate to meet the medication requirement of ulcerative colitis (UC), is increasingly attracting extensive interest. Dendrobium officinale has been widely used to treat gastrointestinal sickness in the clinical treatment of Traditional Chinese Medicine. However, it remains largely unknown whether polysaccharides (DOPS) from Dendrobium officinale can treat UC. The purpose of this paper is to confirm therapeutic action of DOPS to UC and explored its underlying mechanisms. We noted that DOPS could dramatically improve clinical signs and symptoms, decrease mortality, alleviate colonic pathological damage, and reestablish the balance of pro- and anti-inflammatory cytokines in DSS-induced acute UC mice...
April 1, 2018: Carbohydrate Polymers
Hanling Long, Shuai Wang, Jiangnan Dai, Feng Wu, Jun Zhang, Jingwen Chen, Renli Liang, Zhe Chuan Feng, Changqing Chen
In this work, combined analysis of internal strain effects on optical polarization and internal quantum efficiency (IQE) were conducted for the first time. Deep ultraviolet light extraction efficiency of AlGaN multiple quantum wells (MQWs) have been investigated by means of polarization-dependent photoluminescence (PD-PL) and temperature-dependent photoluminescence (TD-PL). With the increase of compressive internal strain applied to the MQWs by an underlying n-AlGaN layer, the degree of polarization (DOP) of the sample was improved from -0...
January 22, 2018: Optics Express
Puyou Jia, Meng Zhang, Lihong Hu, Fei Song, Guodong Feng, Yonghong Zhou
The waste cooking oil (WCO) production from the catering industry and food processing industry causes serious environmental, economic and social problems. However, WCO can be used for the preparation of fine chemicals such as internal plasticizer. With this aim, this work is focused on preparing internal plasticizer by using WCO and determining technical viability of non-migration poly (vinyl chloride) (PVC) materials. The mannich base of waste cooking oil methyl ester (WCOME) was synthesized from WCO via esterification, interesterification and mannich reaction, which was used to produce self-plasticization PVC materials as an internal plasticizer...
January 25, 2018: Scientific Reports
Tomasz Sanak, Robert Brzozowski, Marek Dabrowski, Magdalena Kozak, Agata Dabrowska, Maciej Sip, Katarzyna Naylor, Kamil Torres
BACKGROUND: Application of a tourniquet in a tactical environment is implemented in two ways: the so-called self-aid, which is the application of a tourniquet by the injured, and the so-called buddy aid, which is the application of a tourniquet by the person provide aid. This study aimed to test the quality of tourniquet use in a simulated situation, close quarter battle. METHODS: The study involved 24 injured operators and 72 operators in the whole simulation, implying 12 sections of six individuals...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Nanjing Ji, Lingxiao Lin, Ling Li, Liying Yu, Yaqun Zhang, Hao Luo, Meizhen Li, Xinguo Shi, Da-Zhi Wang, Senjie Lin
Despite numerous laboratory studies on physiologies of harmful algal bloom (HAB) species, physiologies of these algae during a natural bloom are understudied. Here, we investigated a bloom of the raphidophyte Heterosigma akashiwo in the East China Sea in 2014 using metabarcode (18S rDNA) and metatranscriptome sequencing. Based on 18S rDNA analyses, the phytoplankton community shifted from high diversity in the pre-bloom stage to H. akashiwo predominance during the bloom. A sharp decrease in ambient dissolved inorganic phosphate and strong up-regulation of phosphate and dissolved organic phosphorus (DOP) uptake genes, including the rarely documented (ppGpp)ase, in H...
January 18, 2018: Environmental Microbiology
Sushanta Kumar Mishra, Somanath Dash
Background: Health professionals are documented as an important cause for stigmatizing people living with HIV (PLHIV). Since traditional teaching on HIV in India does not address cultural competencies, medical graduates lack sociocultural sensitiveness while addressing the health needs of PLHIV. Aim: The aim of this study is to develop and to implement a module for medical graduates to improve their sociocultural sensitivity toward PLHIV. Methodology: A module was designed and introduced to address the core sensitive issues in HIV among medical graduates with the help of trained faculty...
December 2017: International Journal of Applied and Basic Medical Research
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